Pathophysiology of T follicular helper cells in humans and mice
Identifieur interne : 001C33 ( Pmc/Curation ); précédent : 001C32; suivant : 001C34Pathophysiology of T follicular helper cells in humans and mice
Auteurs : Hideki Ueno [États-Unis] ; Jacques Banchereau [France] ; Carola G. Vinuesa [Australie]Source :
- Nature immunology [ 1529-2908 ] ; 2015.
Abstract
Follicular helper T cells (TFH cells) compose a heterogeneous subset of CD4+ T cells that induce the differentiation of B cells into plasma cells and memory cells. They are found within and in proximity to germinal centers in secondary lymphoid organs, and their memory compartment also circulates in the blood. Our knowledge on the biology of TFH cells has increased significantly during the past decade, largely as a result of mouse studies. However, recent studies on human TFH cells isolated from lymphoid organ and blood samples and recent observations on the developmental mechanism of human TFH cells have revealed both similarities and differences between human and mouse TFH cells. Here we present the similarities and differences between mouse and human lymphoid organ–resident TFH cells and discuss the role of TFH cells in response to vaccines and in disease pathogenesis.
Url:
DOI: 10.1038/ni.3054
PubMed: 25594465
PubMed Central: 4459756
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Vinuesa</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Pathogens and Immunity, John Curtin School of Medical Research, Australian National University, Canberra, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Pathogens and Immunity, John Curtin School of Medical Research, Australian National University, Canberra</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25594465</idno><idno type="pmc">4459756</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459756</idno><idno type="RBID">PMC:4459756</idno><idno type="doi">10.1038/ni.3054</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001D77</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D77</idno><idno type="wicri:Area/Pmc/Curation">001C33</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001C33</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Pathophysiology of T follicular helper cells in humans and mice</title><author><name sortKey="Ueno, Hideki" sort="Ueno, Hideki" uniqKey="Ueno H" first="Hideki" last="Ueno">Hideki Ueno</name><affiliation wicri:level="1"><nlm:aff id="A1">Baylor Institute for Immunology Research, Dallas, Texas, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baylor Institute for Immunology Research, Dallas, Texas</wicri:regionArea></affiliation></author><author><name sortKey="Banchereau, Jacques" sort="Banchereau, Jacques" uniqKey="Banchereau J" first="Jacques" last="Banchereau">Jacques Banchereau</name><affiliation wicri:level="1"><nlm:aff id="A2">Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA, and Vaccine Research Institute, INSERM U955, Hopital Henri Mondor, Creteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA, and Vaccine Research Institute, INSERM U955, Hopital Henri Mondor, Creteil</wicri:regionArea></affiliation></author><author><name sortKey="Vinuesa, Carola G" sort="Vinuesa, Carola G" uniqKey="Vinuesa C" first="Carola G" last="Vinuesa">Carola G. Vinuesa</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Pathogens and Immunity, John Curtin School of Medical Research, Australian National University, Canberra, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Pathogens and Immunity, John Curtin School of Medical Research, Australian National University, Canberra</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature immunology</title><idno type="ISSN">1529-2908</idno><idno type="eISSN">1529-2916</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Follicular helper T cells (T<sub>FH</sub> cells) compose a heterogeneous subset of CD4<sup>+</sup> T cells that induce the differentiation of B cells into plasma cells and memory cells. They are found within and in proximity to germinal centers in secondary lymphoid organs, and their memory compartment also circulates in the blood. Our knowledge on the biology of T<sub>FH</sub> cells has increased significantly during the past decade, largely as a result of mouse studies. However, recent studies on human T<sub>FH</sub> cells isolated from lymphoid organ and blood samples and recent observations on the developmental mechanism of human T<sub>FH</sub> cells have revealed both similarities and differences between human and mouse T<sub>FH</sub> cells. Here we present the similarities and differences between mouse and human lymphoid organ–resident T<sub>FH</sub> cells and discuss the role of T<sub>FH</sub> cells in response to vaccines and in disease pathogenesis.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">100941354</journal-id><journal-id journal-id-type="pubmed-jr-id">21750</journal-id><journal-id journal-id-type="nlm-ta">Nat Immunol</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Immunol.</journal-id><journal-title-group><journal-title>Nature immunology</journal-title></journal-title-group><issn pub-type="ppub">1529-2908</issn><issn pub-type="epub">1529-2916</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25594465</article-id><article-id pub-id-type="pmc">4459756</article-id><article-id pub-id-type="doi">10.1038/ni.3054</article-id><article-id pub-id-type="manuscript">NIHMS687796</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Pathophysiology of T follicular helper cells in humans and mice</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Ueno</surname><given-names>Hideki</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Banchereau</surname><given-names>Jacques</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Vinuesa</surname><given-names>Carola G</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label>Baylor Institute for Immunology Research, Dallas, Texas, USA</aff><aff id="A2"><label>2</label>Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA, and Vaccine Research Institute, INSERM U955, Hopital Henri Mondor, Creteil, France</aff><aff id="A3"><label>3</label>Department of Pathogens and Immunity, John Curtin School of Medical Research, Australian National University, Canberra, Australia</aff><author-notes><corresp id="cor1">Correspondence should be addressed to H.U. (hidekiu@baylorhealth.edu), J.B. (<email>Jacques.banchereau@Jax.org</email>) and C.G.V. (<email>carola.vinuesa@anu.edu.au</email>)</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>7</day><month>5</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>2</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>2</month><year>2016</year></pub-date><volume>16</volume><issue>2</issue><fpage>142</fpage><lpage>152</lpage><pmc-comment>elocation-id from pubmed: 10.1038/ni.3054</pmc-comment>
<permissions><copyright-statement>© 2015 Nature America, Inc. All rights reserved.</copyright-statement><copyright-year>2015</copyright-year><license license-type="permissions-link"><license-p>Reprints and permissions information is available online at <ext-link ext-link-type="uri" xlink:href="http://www.nature.com/reprints/index.html">http://www.nature.com/reprints/index.html</ext-link>.</license-p></license></permissions><abstract><p id="P1">Follicular helper T cells (T<sub>FH</sub> cells) compose a heterogeneous subset of CD4<sup>+</sup> T cells that induce the differentiation of B cells into plasma cells and memory cells. They are found within and in proximity to germinal centers in secondary lymphoid organs, and their memory compartment also circulates in the blood. Our knowledge on the biology of T<sub>FH</sub> cells has increased significantly during the past decade, largely as a result of mouse studies. However, recent studies on human T<sub>FH</sub> cells isolated from lymphoid organ and blood samples and recent observations on the developmental mechanism of human T<sub>FH</sub> cells have revealed both similarities and differences between human and mouse T<sub>FH</sub> cells. Here we present the similarities and differences between mouse and human lymphoid organ–resident T<sub>FH</sub> cells and discuss the role of T<sub>FH</sub> cells in response to vaccines and in disease pathogenesis.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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