Der p 11 Is a Major Allergen for House Dust Mite-Allergic Patients Suffering from Atopic Dermatitis
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Auteurs : Srinita Banerjee [Autriche] ; Yvonne Resch [Autriche] ; Kuan-Wei Chen [Autriche] ; Ines Swoboda [Autriche] ; Margit Focke-Tejkl [Autriche] ; Katharina Blatt [Autriche] ; Natalija Novak [Allemagne] ; Magnus Wickman [Suède] ; Marianne Van Hage [Suède] ; Rosetta Ferrara [Italie] ; Adriano Mari [Italie] ; Ashok Purohit [France] ; Gabrielle Pauli [France] ; Elopy N. Sibanda [Zimbabwe] ; Portia Ndlovu [Zimbabwe] ; Wayne R. Thomas [Australie] ; Vladislav Krzyzanek [République tchèque] ; Sebastian Tacke [Allemagne] ; Ursula Malkus [Allemagne] ; Peter Valent [Autriche] ; Rudolf Valenta [Autriche] ; Susanne Vrtala [Autriche]Source :
- The Journal of investigative dermatology [ 0022-202X ] ; 2014.
Abstract
House dust mites (HDMs) belong to the most potent indoor allergen sources worldwide and are associated with allergic manifestations in the respiratory tract and the skin. Here we studied the importance of the high-molecular-weight group 11 allergen from
Url:
DOI: 10.1038/jid.2014.271
PubMed: 24999597
PubMed Central: 4636057
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id="A1">Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Kuan Wei" sort="Chen, Kuan Wei" uniqKey="Chen K" first="Kuan-Wei" last="Chen">Kuan-Wei Chen</name><affiliation wicri:level="1"><nlm:aff id="A1">Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for 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Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna</wicri:regionArea></affiliation></author><author><name sortKey="Novak, Natalija" sort="Novak, Natalija" uniqKey="Novak N" first="Natalija" last="Novak">Natalija Novak</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Dermatology and Allergy, University of Bonn, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology and Allergy, University of Bonn, Bonn</wicri:regionArea></affiliation></author><author><name sortKey="Wickman, Magnus" sort="Wickman, Magnus" uniqKey="Wickman M" first="Magnus" last="Wickman">Magnus Wickman</name><affiliation wicri:level="1"><nlm:aff id="A5">Sachs’ Children’s Hospital and Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Sachs’ Children’s Hospital and Institute of Environmental Medicine, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Van Hage, Marianne" sort="Van Hage, Marianne" uniqKey="Van Hage M" first="Marianne" last="Van Hage">Marianne Van Hage</name><affiliation wicri:level="1"><nlm:aff id="A6">Clinical Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet and University Hospital Stockholm, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Clinical Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet and University Hospital Stockholm, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Ferrara, Rosetta" sort="Ferrara, Rosetta" uniqKey="Ferrara R" first="Rosetta" last="Ferrara">Rosetta Ferrara</name><affiliation wicri:level="1"><nlm:aff id="A7">Center for Molecular Allergology, IDI-IRCCS, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Molecular Allergology, IDI-IRCCS, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Mari, Adriano" sort="Mari, Adriano" uniqKey="Mari A" first="Adriano" last="Mari">Adriano Mari</name><affiliation wicri:level="1"><nlm:aff id="A7">Center for Molecular Allergology, IDI-IRCCS, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Molecular Allergology, IDI-IRCCS, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Purohit, Ashok" sort="Purohit, Ashok" uniqKey="Purohit A" first="Ashok" last="Purohit">Ashok Purohit</name><affiliation wicri:level="1"><nlm:aff id="A8">Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Pauli, Gabrielle" sort="Pauli, Gabrielle" uniqKey="Pauli G" first="Gabrielle" last="Pauli">Gabrielle Pauli</name><affiliation wicri:level="1"><nlm:aff id="A8">Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Sibanda, Elopy N" sort="Sibanda, Elopy N" uniqKey="Sibanda E" first="Elopy N." last="Sibanda">Elopy N. Sibanda</name><affiliation wicri:level="1"><nlm:aff id="A9">Gamma City Laboratory, Harare, Zimbabwe</nlm:aff><country xml:lang="fr">Zimbabwe</country><wicri:regionArea>Gamma City Laboratory, Harare</wicri:regionArea></affiliation></author><author><name sortKey="Ndlovu, Portia" sort="Ndlovu, Portia" uniqKey="Ndlovu P" first="Portia" last="Ndlovu">Portia Ndlovu</name><affiliation wicri:level="1"><nlm:aff id="A9">Gamma City Laboratory, Harare, Zimbabwe</nlm:aff><country xml:lang="fr">Zimbabwe</country><wicri:regionArea>Gamma City Laboratory, Harare</wicri:regionArea></affiliation></author><author><name sortKey="Thomas, Wayne R" sort="Thomas, Wayne R" uniqKey="Thomas W" first="Wayne R." last="Thomas">Wayne R. Thomas</name><affiliation wicri:level="1"><nlm:aff id="A10">Center for Child Health Research, Telethon Institute of Child Health Research, University of Western Australia, Perth, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Center for Child Health Research, Telethon Institute of Child Health Research, University of Western Australia, Perth</wicri:regionArea></affiliation></author><author><name sortKey="Krzyzanek, Vladislav" sort="Krzyzanek, Vladislav" uniqKey="Krzyzanek V" first="Vladislav" last="Krzyzanek">Vladislav Krzyzanek</name><affiliation wicri:level="1"><nlm:aff id="A11">Institute of Scientific Instruments, Academy of Sciences of the Czech Republic, Brno, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Institute of Scientific Instruments, Academy of Sciences of the Czech Republic, Brno</wicri:regionArea></affiliation></author><author><name sortKey="Tacke, Sebastian" sort="Tacke, Sebastian" uniqKey="Tacke S" first="Sebastian" last="Tacke">Sebastian Tacke</name><affiliation wicri:level="1"><nlm:aff id="A12">Institute of Medical Physics and Biophysics, University of Münster, Münster, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Physics and Biophysics, University of Münster, Münster</wicri:regionArea></affiliation></author><author><name sortKey="Malkus, Ursula" sort="Malkus, Ursula" uniqKey="Malkus U" first="Ursula" last="Malkus">Ursula Malkus</name><affiliation wicri:level="1"><nlm:aff id="A12">Institute of Medical Physics and Biophysics, University of Münster, Münster, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Physics and Biophysics, University of Münster, Münster</wicri:regionArea></affiliation></author><author><name sortKey="Valent, Peter" sort="Valent, Peter" uniqKey="Valent P" first="Peter" last="Valent">Peter Valent</name><affiliation wicri:level="1"><nlm:aff id="A3">Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna</wicri:regionArea></affiliation></author><author><name sortKey="Valenta, Rudolf" sort="Valenta, Rudolf" uniqKey="Valenta R" first="Rudolf" last="Valenta">Rudolf Valenta</name><affiliation wicri:level="1"><nlm:aff id="A1">Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Christian Doppler Laboratory for Allergy Research, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Christian Doppler Laboratory for Allergy Research, Medical University of Vienna, Vienna</wicri:regionArea></affiliation></author><author><name sortKey="Vrtala, Susanne" sort="Vrtala, Susanne" uniqKey="Vrtala S" first="Susanne" last="Vrtala">Susanne Vrtala</name><affiliation wicri:level="1"><nlm:aff id="A1">Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Christian Doppler Laboratory for the Development of Allergen Chips, Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Christian Doppler Laboratory for the Development of Allergen Chips, Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24999597</idno><idno type="pmc">4636057</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636057</idno><idno type="RBID">PMC:4636057</idno><idno type="doi">10.1038/jid.2014.271</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001D58</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D58</idno><idno 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sortKey="Resch, Yvonne" sort="Resch, Yvonne" uniqKey="Resch Y" first="Yvonne" last="Resch">Yvonne Resch</name><affiliation wicri:level="1"><nlm:aff id="A1">Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Kuan Wei" sort="Chen, Kuan Wei" uniqKey="Chen K" first="Kuan-Wei" last="Chen">Kuan-Wei Chen</name><affiliation wicri:level="1"><nlm:aff id="A1">Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna</wicri:regionArea></affiliation></author><author><name sortKey="Swoboda, Ines" sort="Swoboda, Ines" uniqKey="Swoboda I" first="Ines" last="Swoboda">Ines Swoboda</name><affiliation wicri:level="1"><nlm:aff id="A1">Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Christian Doppler Laboratory for Allergy Research, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Christian Doppler Laboratory for Allergy Research, Medical University of Vienna, Vienna</wicri:regionArea></affiliation></author><author><name sortKey="Focke Tejkl, Margit" sort="Focke Tejkl, Margit" uniqKey="Focke Tejkl M" first="Margit" last="Focke-Tejkl">Margit Focke-Tejkl</name><affiliation wicri:level="1"><nlm:aff id="A2">Christian Doppler Laboratory for Allergy Research, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Christian Doppler Laboratory for Allergy Research, Medical University of Vienna, Vienna</wicri:regionArea></affiliation></author><author><name sortKey="Blatt, Katharina" sort="Blatt, Katharina" uniqKey="Blatt K" first="Katharina" last="Blatt">Katharina Blatt</name><affiliation wicri:level="1"><nlm:aff id="A3">Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna</wicri:regionArea></affiliation></author><author><name sortKey="Novak, Natalija" sort="Novak, Natalija" uniqKey="Novak N" first="Natalija" last="Novak">Natalija Novak</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Dermatology and Allergy, University of Bonn, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology and Allergy, University of Bonn, Bonn</wicri:regionArea></affiliation></author><author><name sortKey="Wickman, Magnus" sort="Wickman, Magnus" uniqKey="Wickman M" first="Magnus" last="Wickman">Magnus Wickman</name><affiliation wicri:level="1"><nlm:aff id="A5">Sachs’ Children’s Hospital and Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Sachs’ Children’s Hospital and Institute of Environmental Medicine, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Van Hage, Marianne" sort="Van Hage, Marianne" uniqKey="Van Hage M" first="Marianne" last="Van Hage">Marianne Van Hage</name><affiliation wicri:level="1"><nlm:aff id="A6">Clinical Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet and University Hospital Stockholm, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Clinical Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet and University Hospital Stockholm, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Ferrara, Rosetta" sort="Ferrara, Rosetta" uniqKey="Ferrara R" first="Rosetta" last="Ferrara">Rosetta Ferrara</name><affiliation wicri:level="1"><nlm:aff id="A7">Center for Molecular Allergology, IDI-IRCCS, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Molecular Allergology, IDI-IRCCS, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Mari, Adriano" sort="Mari, Adriano" uniqKey="Mari A" first="Adriano" last="Mari">Adriano Mari</name><affiliation wicri:level="1"><nlm:aff id="A7">Center for Molecular Allergology, IDI-IRCCS, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Molecular Allergology, IDI-IRCCS, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Purohit, Ashok" sort="Purohit, Ashok" uniqKey="Purohit A" first="Ashok" last="Purohit">Ashok Purohit</name><affiliation wicri:level="1"><nlm:aff id="A8">Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Pauli, Gabrielle" sort="Pauli, Gabrielle" uniqKey="Pauli G" first="Gabrielle" last="Pauli">Gabrielle Pauli</name><affiliation wicri:level="1"><nlm:aff id="A8">Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Sibanda, Elopy N" sort="Sibanda, Elopy N" uniqKey="Sibanda E" first="Elopy N." last="Sibanda">Elopy N. Sibanda</name><affiliation wicri:level="1"><nlm:aff id="A9">Gamma City Laboratory, Harare, Zimbabwe</nlm:aff><country xml:lang="fr">Zimbabwe</country><wicri:regionArea>Gamma City Laboratory, Harare</wicri:regionArea></affiliation></author><author><name sortKey="Ndlovu, Portia" sort="Ndlovu, Portia" uniqKey="Ndlovu P" first="Portia" last="Ndlovu">Portia Ndlovu</name><affiliation wicri:level="1"><nlm:aff id="A9">Gamma City Laboratory, Harare, Zimbabwe</nlm:aff><country xml:lang="fr">Zimbabwe</country><wicri:regionArea>Gamma City Laboratory, Harare</wicri:regionArea></affiliation></author><author><name sortKey="Thomas, Wayne R" sort="Thomas, Wayne R" uniqKey="Thomas W" first="Wayne R." last="Thomas">Wayne R. Thomas</name><affiliation wicri:level="1"><nlm:aff id="A10">Center for Child Health Research, Telethon Institute of Child Health Research, University of Western Australia, Perth, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Center for Child Health Research, Telethon Institute of Child Health Research, University of Western Australia, Perth</wicri:regionArea></affiliation></author><author><name sortKey="Krzyzanek, Vladislav" sort="Krzyzanek, Vladislav" uniqKey="Krzyzanek V" first="Vladislav" last="Krzyzanek">Vladislav Krzyzanek</name><affiliation wicri:level="1"><nlm:aff id="A11">Institute of Scientific Instruments, Academy of Sciences of the Czech Republic, Brno, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Institute of Scientific Instruments, Academy of Sciences of the Czech Republic, Brno</wicri:regionArea></affiliation></author><author><name sortKey="Tacke, Sebastian" sort="Tacke, Sebastian" uniqKey="Tacke S" first="Sebastian" last="Tacke">Sebastian Tacke</name><affiliation wicri:level="1"><nlm:aff id="A12">Institute of Medical Physics and Biophysics, University of Münster, Münster, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Physics and Biophysics, University of Münster, Münster</wicri:regionArea></affiliation></author><author><name sortKey="Malkus, Ursula" sort="Malkus, Ursula" uniqKey="Malkus U" first="Ursula" last="Malkus">Ursula Malkus</name><affiliation wicri:level="1"><nlm:aff id="A12">Institute of Medical Physics and Biophysics, University of Münster, Münster, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Physics and Biophysics, University of Münster, Münster</wicri:regionArea></affiliation></author><author><name sortKey="Valent, Peter" sort="Valent, Peter" uniqKey="Valent P" first="Peter" last="Valent">Peter Valent</name><affiliation wicri:level="1"><nlm:aff id="A3">Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna</wicri:regionArea></affiliation></author><author><name sortKey="Valenta, Rudolf" sort="Valenta, Rudolf" uniqKey="Valenta R" first="Rudolf" last="Valenta">Rudolf Valenta</name><affiliation wicri:level="1"><nlm:aff id="A1">Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Christian Doppler Laboratory for Allergy Research, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Christian Doppler Laboratory for Allergy Research, Medical University of Vienna, Vienna</wicri:regionArea></affiliation></author><author><name sortKey="Vrtala, Susanne" sort="Vrtala, Susanne" uniqKey="Vrtala S" first="Susanne" last="Vrtala">Susanne Vrtala</name><affiliation wicri:level="1"><nlm:aff id="A1">Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Christian Doppler Laboratory for the Development of Allergen Chips, Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Christian Doppler Laboratory for the Development of Allergen Chips, Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Journal of investigative dermatology</title><idno type="ISSN">0022-202X</idno><idno type="eISSN">1523-1747</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P3">House dust mites (HDMs) belong to the most potent indoor allergen sources worldwide and are associated with allergic manifestations in the respiratory tract and the skin. Here we studied the importance of the high-molecular-weight group 11 allergen from <italic>Dermatophagoides pteronyssinus</italic> (Der p 11) in HDM allergy. Sequence analysis showed that Der p 11 has high homology to paramyosins from mites, ticks, and other invertebrates. A synthetic gene coding for Der p 11 was expressed in <italic>Escherichia coli</italic> and rDer p 11 purified to homogeneity as folded, alpha-helical protein as determined by circular dichroism spectroscopy. Using antibodies raised against rDer p 11 and immunogold electron microscopy, the allergen was localized in the muscle beneath the skin of mite bodies but not in feces. IgE reactivity of rDer p 11 was tested with sera from HDM-allergic patients from Europe and Africa in radioallergosorbent test–based dot-blot assays. Interestingly, we found that Der p 11 is a major allergen for patients suffering from atopic dermatitis (AD), whereas it is only a minor allergen for patients suffering from respiratory forms of HDM allergy. Thus, rDer p 11 might be a useful serological marker allergen for the identification of a subgroup of HDM-allergic patients suffering from HDM-associated AD.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0426720</journal-id><journal-id journal-id-type="pubmed-jr-id">4839</journal-id><journal-id journal-id-type="nlm-ta">J Invest Dermatol</journal-id><journal-id journal-id-type="iso-abbrev">J. Invest. Dermatol.</journal-id><journal-title-group><journal-title>The Journal of investigative dermatology</journal-title></journal-title-group><issn pub-type="ppub">0022-202X</issn><issn pub-type="epub">1523-1747</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24999597</article-id><article-id pub-id-type="pmc">4636057</article-id><article-id pub-id-type="doi">10.1038/jid.2014.271</article-id><article-id pub-id-type="manuscript">EMS65213</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Der p 11 Is a Major Allergen for House Dust Mite-Allergic Patients Suffering from Atopic Dermatitis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Banerjee</surname><given-names>Srinita</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Resch</surname><given-names>Yvonne</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Kuan-Wei</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Swoboda</surname><given-names>Ines</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="author-notes" rid="FN1">14</xref></contrib><contrib contrib-type="author"><name><surname>Focke-Tejkl</surname><given-names>Margit</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Blatt</surname><given-names>Katharina</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Novak</surname><given-names>Natalija</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Wickman</surname><given-names>Magnus</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>van Hage</surname><given-names>Marianne</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Ferrara</surname><given-names>Rosetta</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="author-notes" rid="FN2">15</xref></contrib><contrib contrib-type="author"><name><surname>Mari</surname><given-names>Adriano</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="author-notes" rid="FN2">15</xref></contrib><contrib contrib-type="author"><name><surname>Purohit</surname><given-names>Ashok</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Pauli</surname><given-names>Gabrielle</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Sibanda</surname><given-names>Elopy N.</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Ndlovu</surname><given-names>Portia</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Thomas</surname><given-names>Wayne R.</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Krzyzanek</surname><given-names>Vladislav</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Tacke</surname><given-names>Sebastian</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Malkus</surname><given-names>Ursula</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Valent</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Valenta</surname><given-names>Rudolf</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Vrtala</surname><given-names>Susanne</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A13">13</xref></contrib></contrib-group><aff id="A1"><label>1</label>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria</aff><aff id="A2"><label>2</label>Christian Doppler Laboratory for Allergy Research, Medical University of Vienna, Vienna, Austria</aff><aff id="A3"><label>3</label>Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria</aff><aff id="A4"><label>4</label>Department of Dermatology and Allergy, University of Bonn, Bonn, Germany</aff><aff id="A5"><label>5</label>Sachs’ Children’s Hospital and Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A6"><label>6</label>Clinical Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet and University Hospital Stockholm, Stockholm, Sweden</aff><aff id="A7"><label>7</label>Center for Molecular Allergology, IDI-IRCCS, Rome, Italy</aff><aff id="A8"><label>8</label>Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France</aff><aff id="A9"><label>9</label>Gamma City Laboratory, Harare, Zimbabwe</aff><aff id="A10"><label>10</label>Center for Child Health Research, Telethon Institute of Child Health Research, University of Western Australia, Perth, Australia</aff><aff id="A11"><label>11</label>Institute of Scientific Instruments, Academy of Sciences of the Czech Republic, Brno, Czech Republic</aff><aff id="A12"><label>12</label>Institute of Medical Physics and Biophysics, University of Münster, Münster, Germany</aff><aff id="A13"><label>13</label>Christian Doppler Laboratory for the Development of Allergen Chips, Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria</aff><author-notes><corresp id="CR1">Correspondence: Susanne Vrtala, Christian Doppler Laboratory for the Development of Allergen Chips, Department of Pathophysiology and Allergy Research, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. <email>susanne.vrtala@meduniwien.ac.at</email></corresp><fn fn-type="present-address" id="FN1"><label>14</label><p id="P1">Present address: Section of Molecular Biotechnology, University of Applied Science, Campus Vienna Biocenter, Vienna, Austria.</p></fn><fn fn-type="present-address" id="FN2"><label>15</label><p id="P2">Present address: Associated Centers for Molecular Allergology, Rome, Italy.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>2</day><month>11</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>07</day><month>8</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>1</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>06</day><month>11</month><year>2015</year></pub-date><volume>135</volume><issue>1</issue><fpage>102</fpage><lpage>109</lpage><pmc-comment>elocation-id from pubmed: 10.1038/jid.2014.271</pmc-comment>
<abstract><p id="P3">House dust mites (HDMs) belong to the most potent indoor allergen sources worldwide and are associated with allergic manifestations in the respiratory tract and the skin. Here we studied the importance of the high-molecular-weight group 11 allergen from <italic>Dermatophagoides pteronyssinus</italic> (Der p 11) in HDM allergy. Sequence analysis showed that Der p 11 has high homology to paramyosins from mites, ticks, and other invertebrates. A synthetic gene coding for Der p 11 was expressed in <italic>Escherichia coli</italic> and rDer p 11 purified to homogeneity as folded, alpha-helical protein as determined by circular dichroism spectroscopy. Using antibodies raised against rDer p 11 and immunogold electron microscopy, the allergen was localized in the muscle beneath the skin of mite bodies but not in feces. IgE reactivity of rDer p 11 was tested with sera from HDM-allergic patients from Europe and Africa in radioallergosorbent test–based dot-blot assays. Interestingly, we found that Der p 11 is a major allergen for patients suffering from atopic dermatitis (AD), whereas it is only a minor allergen for patients suffering from respiratory forms of HDM allergy. Thus, rDer p 11 might be a useful serological marker allergen for the identification of a subgroup of HDM-allergic patients suffering from HDM-associated AD.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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