Acrylamide and glycidamide hemoglobin adducts and epithelial ovarian cancer: a nested case-control study in non-smoking postmenopausal women from the EPIC cohort
Identifieur interne : 001B16 ( Pmc/Curation ); précédent : 001B15; suivant : 001B17Acrylamide and glycidamide hemoglobin adducts and epithelial ovarian cancer: a nested case-control study in non-smoking postmenopausal women from the EPIC cohort
Auteurs : Mireia Ob N-Santacana [Espagne] ; Leila Lujan-Barroso [Espagne] ; Ruth C. Travis [Royaume-Uni] ; Heinz Freisling [France] ; Pietro Ferrari [France] ; Gianluca Severi [Italie] ; Laura Baglietto [Australie] ; Marie-Christine Boutron-Ruault [France] ; Renée T. Fortner [Allemagne] ; Jennifer Ose [Allemagne] ; Heiner Boeing [Allemagne] ; Virginia Menéndez [Espagne] ; Emilio Sánchez-Cantalejo [Espagne] ; Saioa Chamosa [Espagne] ; José María Huerta Casta O [Espagne] ; Eva Ardanaz [Espagne] ; Kay-Tee Khaw [Royaume-Uni] ; Nick Wareham [Royaume-Uni] ; Melissa A. Merritt [Royaume-Uni] ; Marc J. Gunter [Royaume-Uni] ; Antonia Trichopoulou [Grèce] ; Eleni-Maria Papatesta [Grèce] ; Eleni Klinaki [Grèce] ; Calogero Saieva ; Giovanna Tagliabue [Italie] ; Rosario Tumino ; Carlotta Sacerdote [Italie] ; Amalia Mattiello [Italie] ; H. B. Bueno-De-Mesquita [Royaume-Uni, Pays-Bas, Malaisie] ; Petra H. Peeters [Royaume-Uni, Pays-Bas] ; N. Charlotte Onland-Moret [Pays-Bas] ; Annika Idahl [Suède] ; Eva Lundin [Suède] ; Elisabete Weiderpass [Norvège, Suède, Finlande] ; Hubert W. Vesper [États-Unis] ; Elio Riboli [Royaume-Uni] ; Eric J. Duell [Espagne]Source :
- International journal of cancer [ 0020-7136 ] ; 2015.
Abstract
Acrylamide was classified as ‘probably carcinogenic to humans (group 2A)’ by the International Agency for Research on Cancer. Epithelial ovarian cancer (EOC) is the fourth cause of cancer mortality in women. Five epidemiological studies have evaluated the association between EOC risk and dietary acrylamide intake assessed using food frequency questionnaires, and one nested case-control study evaluated hemoglobin adducts of acrylamide (HbAA) and its metabolite glycidamide (HbGA) and EOC risk; the results of these studies were inconsistent.
A nested case-control study in non-smoking postmenopausal women (334 cases, 417 controls) was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association between HbAA, HbGA, HbAA+HbGA, and HbGA/HbAA and EOC and invasive serous EOC risk.
No overall associations were observed between biomarkers of acrylamide exposure analyzed in quintiles and EOC risk; however, positive associations were observed between some middle quintiles of HbGA and HbAA+HbGA. Elevated but non-statistically significant ORs for serous EOC were observed for HbGA and HbAA+HbGA (ORQ5
This EPIC nested case-control study failed to observe a clear association between biomarkers of acrylamide exposure and the risk of EOC or invasive serous EOC.
It is unlikely that dietary acrylamide exposure increases ovarian cancer risk; however, additional studies with larger sample size should be performed to exclude any possible association with EOC risk.
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DOI: 10.1002/ijc.29853
PubMed: 26376083
PubMed Central: 4716289
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Calogero Saieva<affiliation><nlm:aff id="A24">Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence- Italy</nlm:aff><wicri:noCountry code="subfield">Florence- Italy</wicri:noCountry></affiliation><affiliation><nlm:aff id="A26">Cancer Registry and Histopathology Unit, “Civic - M.P.Arezzo” Hospital, ASP Ragusa (Italy)</nlm:aff><wicri:noCountry code="subfield">ASP Ragusa (Italy)</wicri:noCountry></affiliation>Le document en format XML
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Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Lujan Barroso, Leila" sort="Lujan Barroso, Leila" uniqKey="Lujan Barroso L" first="Leila" last="Lujan-Barroso">Leila Lujan-Barroso</name><affiliation wicri:level="1"><nlm:aff id="A1">Unit of Nutrition and Cancer. Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Nutrition and Cancer. Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation wicri:level="3"><nlm:aff id="A2">Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, Oxford</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><wicri:orgArea>Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford</wicri:orgArea></affiliation></author><author><name sortKey="Freisling, Heinz" sort="Freisling, Heinz" uniqKey="Freisling H" first="Heinz" last="Freisling">Heinz Freisling</name><affiliation wicri:level="1"><nlm:aff id="A3">Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Ferrari, Pietro" sort="Ferrari, Pietro" uniqKey="Ferrari P" first="Pietro" last="Ferrari">Pietro Ferrari</name><affiliation wicri:level="1"><nlm:aff id="A3">Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation wicri:level="1"><nlm:aff id="A4">Human Genetics Foundation (HuGeF), Torino, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Human Genetics Foundation (HuGeF), Torino</wicri:regionArea></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation wicri:level="1"><nlm:aff id="A5">Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><affiliation wicri:level="1"><nlm:aff id="A7">Inserm, CESP Centre for Research in Epidemiology and Population Health, U1018, Lifestyle, genes and health: integrative trans-generational epidemiology, F-94805, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, CESP Centre for Research in Epidemiology and Population Health, U1018, Lifestyle, genes and health: integrative trans-generational epidemiology, F-94805, Villejuif</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Univ Paris Sud, UMRS 1018, F-94805, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ Paris Sud, UMRS 1018, F-94805, Villejuif</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Gustave Roussy, F-94805, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Gustave Roussy, F-94805, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Fortner, Renee T" sort="Fortner, Renee T" uniqKey="Fortner R" first="Renée T." last="Fortner">Renée T. Fortner</name><affiliation wicri:level="1"><nlm:aff id="A10">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Ose, Jennifer" sort="Ose, Jennifer" uniqKey="Ose J" first="Jennifer" last="Ose">Jennifer Ose</name><affiliation wicri:level="1"><nlm:aff id="A10">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation wicri:level="1"><nlm:aff id="A11">Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal</wicri:regionArea></affiliation></author><author><name sortKey="Menendez, Virginia" sort="Menendez, Virginia" uniqKey="Menendez V" first="Virginia" last="Menéndez">Virginia Menéndez</name><affiliation wicri:level="1"><nlm:aff id="A12">Public Health Directorate, Asturias, Spain.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Espagne</country><wicri:regionArea>Public Health Directorate, Asturias</wicri:regionArea></affiliation></author><author><name sortKey="Sanchez Cantalejo, Emilio" sort="Sanchez Cantalejo, Emilio" uniqKey="Sanchez Cantalejo E" first="Emilio" last="Sánchez-Cantalejo">Emilio Sánchez-Cantalejo</name><affiliation wicri:level="1"><nlm:aff id="A13">CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiology and Public Health CIBERESP, Madrid</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A14">Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada</wicri:regionArea></affiliation></author><author><name sortKey="Chamosa, Saioa" sort="Chamosa, Saioa" uniqKey="Chamosa S" first="Saioa" last="Chamosa">Saioa Chamosa</name><affiliation wicri:level="1"><nlm:aff id="A15">Public Health Division of Gipuzkoa-BIODONOSTIA, Basque Regional Health Department, San Sebastian, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Public Health Division of Gipuzkoa-BIODONOSTIA, Basque Regional Health Department, San Sebastian</wicri:regionArea></affiliation></author><author><name sortKey="Huerta Casta O, Jose Maria" sort="Huerta Casta O, Jose Maria" uniqKey="Huerta Casta O J" first="José María" last="Huerta Casta O">José María Huerta Casta O</name><affiliation wicri:level="1"><nlm:aff id="A13">CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiology and Public Health CIBERESP, Madrid</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A16">Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Espagne</country><wicri:regionArea>Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia</wicri:regionArea></affiliation></author><author><name sortKey="Ardanaz, Eva" sort="Ardanaz, Eva" uniqKey="Ardanaz E" first="Eva" last="Ardanaz">Eva Ardanaz</name><affiliation wicri:level="1"><nlm:aff id="A13">CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiology and Public Health CIBERESP, Madrid</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A17">Navarra Public Health Institute, Pamplona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Navarra Public Health Institute, Pamplona</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A18">IdiSNA, Navarra Institute for Health Research, Pamplona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>IdiSNA, Navarra Institute for Health Research, Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="1"><nlm:aff id="A19">University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Cambridge School of Clinical Medicine, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Wareham, Nick" sort="Wareham, Nick" uniqKey="Wareham N" first="Nick" last="Wareham">Nick Wareham</name><affiliation wicri:level="1"><nlm:aff id="A20">Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, Oxford, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Merritt, Melissa A" sort="Merritt, Melissa A" uniqKey="Merritt M" first="Melissa A." last="Merritt">Melissa A. Merritt</name><affiliation wicri:level="1"><nlm:aff id="A21">Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J." last="Gunter">Marc J. Gunter</name><affiliation wicri:level="1"><nlm:aff id="A21">Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name><affiliation wicri:level="1"><nlm:aff id="A22">Hellenic Health Foundation, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A23">WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School</wicri:regionArea></affiliation></author><author><name sortKey="Papatesta, Eleni Maria" sort="Papatesta, Eleni Maria" uniqKey="Papatesta E" first="Eleni-Maria" last="Papatesta">Eleni-Maria Papatesta</name><affiliation wicri:level="1"><nlm:aff id="A22">Hellenic Health Foundation, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Klinaki, Eleni" sort="Klinaki, Eleni" uniqKey="Klinaki E" first="Eleni" last="Klinaki">Eleni Klinaki</name><affiliation wicri:level="1"><nlm:aff id="A22">Hellenic Health Foundation, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Saieva, Calogero" sort="Saieva, Calogero" uniqKey="Saieva C" first="Calogero" last="Saieva">Calogero Saieva</name><affiliation><nlm:aff id="A24">Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence- Italy</nlm:aff><wicri:noCountry code="subfield">Florence- Italy</wicri:noCountry></affiliation></author><author><name sortKey="Tagliabue, Giovanna" sort="Tagliabue, Giovanna" uniqKey="Tagliabue G" first="Giovanna" last="Tagliabue">Giovanna Tagliabue</name><affiliation wicri:level="1"><nlm:aff id="A25">Lombardy Cancer Registry Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Lombardy Cancer Registry Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano</wicri:regionArea></affiliation></author><author><name sortKey="Tumino, Rosario" sort="Tumino, Rosario" uniqKey="Tumino R" first="Rosario" last="Tumino">Rosario Tumino</name><affiliation><nlm:aff id="A26">Cancer Registry and Histopathology Unit, “Civic - M.P.Arezzo” Hospital, ASP Ragusa (Italy)</nlm:aff><wicri:noCountry code="subfield">ASP Ragusa (Italy)</wicri:noCountry></affiliation></author><author><name sortKey="Sacerdote, Carlotta" sort="Sacerdote, Carlotta" uniqKey="Sacerdote C" first="Carlotta" last="Sacerdote">Carlotta Sacerdote</name><affiliation wicri:level="1"><nlm:aff id="A27">Unit of Cancer Epidemiology, Citta' della Salute e della Scienza Hospital-University of Turin and Center for Cancer Prevention (CPO), Torino, Italy.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Italie</country><wicri:regionArea>Unit of Cancer Epidemiology, Citta' della Salute e della Scienza Hospital-University of Turin and Center for Cancer Prevention (CPO), Torino</wicri:regionArea></affiliation></author><author><name sortKey="Mattiello, Amalia" sort="Mattiello, Amalia" uniqKey="Mattiello A" first="Amalia" last="Mattiello">Amalia Mattiello</name><affiliation wicri:level="1"><nlm:aff id="A28">Dipartamiento di Medicina Clinica e Chirurgia Federico II University, Naples, Italy.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Italie</country><wicri:regionArea>Dipartamiento di Medicina Clinica e Chirurgia Federico II University, Naples</wicri:regionArea></affiliation></author><author><name sortKey="Bueno De Mesquita, H B" sort="Bueno De Mesquita, H B" uniqKey="Bueno De Mesquita H" first="H. B." last="Bueno-De-Mesquita">H. B. Bueno-De-Mesquita</name><affiliation wicri:level="1"><nlm:aff id="A21">Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A29">Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A30">Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A31">Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Malaisie</country><wicri:regionArea>Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur</wicri:regionArea></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name><affiliation wicri:level="1"><nlm:aff id="A21">Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A32">Department of Epidemiology, Julius Center for Health Sciences and Primary Care,University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Julius Center for Health Sciences and Primary Care,University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N. Charlotte" last="Onland-Moret">N. Charlotte Onland-Moret</name><affiliation wicri:level="1"><nlm:aff id="A33">Julius Center for Health Scienes and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Julius Center for Health Scienes and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Idahl, Annika" sort="Idahl, Annika" uniqKey="Idahl A" first="Annika" last="Idahl">Annika Idahl</name><affiliation wicri:level="1"><nlm:aff id="A34">Department of Clinical Sciences, Obstetrics and Gynecology Nutritional Research Umeå University, Umeå, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Obstetrics and Gynecology Nutritional Research Umeå University, Umeå</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A35">Department of Public Health and Clinical Medicine, Nutritional Research Umeå University, Umeå, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Public Health and Clinical Medicine, Nutritional Research Umeå University, Umeå</wicri:regionArea></affiliation></author><author><name sortKey="Lundin, Eva" sort="Lundin, Eva" uniqKey="Lundin E" first="Eva" last="Lundin">Eva Lundin</name><affiliation wicri:level="1"><nlm:aff id="A36">Department of Medical Biosciences, Pathology Umeå University, Umeå, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Biosciences, Pathology Umeå University, Umeå</wicri:regionArea></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation wicri:level="1"><nlm:aff id="A37">Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Norvège</country><wicri:regionArea>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A38">Department of Research, Cancer Registry of Norway, Oslo, Norway.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Norvège</country><wicri:regionArea>Department of Research, Cancer Registry of Norway, Oslo</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A40">Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Vesper, Hubert W" sort="Vesper, Hubert W" uniqKey="Vesper H" first="Hubert W." last="Vesper">Hubert W. Vesper</name><affiliation wicri:level="1"><nlm:aff id="A41">Centers for Disease Control and Prevention, Atlanta, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Centers for Disease Control and Prevention, Atlanta</wicri:regionArea></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation wicri:level="1"><nlm:aff id="A21">Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Duell, Eric J" sort="Duell, Eric J" uniqKey="Duell E" first="Eric J" last="Duell">Eric J. Duell</name><affiliation wicri:level="1"><nlm:aff id="A1">Unit of Nutrition and Cancer. Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Nutrition and Cancer. Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26376083</idno><idno type="pmc">4716289</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716289</idno><idno type="RBID">PMC:4716289</idno><idno type="doi">10.1002/ijc.29853</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001C58</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001C58</idno><idno type="wicri:Area/Pmc/Curation">001B16</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001B16</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Acrylamide and glycidamide hemoglobin adducts and epithelial ovarian cancer: a nested case-control study in non-smoking postmenopausal women from the EPIC cohort</title><author><name sortKey="Ob N Santacana, Mireia" sort="Ob N Santacana, Mireia" uniqKey="Ob N Santacana M" first="Mireia" last="Ob N-Santacana">Mireia Ob N-Santacana</name><affiliation wicri:level="1"><nlm:aff id="A1">Unit of Nutrition and Cancer. Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Nutrition and Cancer. Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Lujan Barroso, Leila" sort="Lujan Barroso, Leila" uniqKey="Lujan Barroso L" first="Leila" last="Lujan-Barroso">Leila Lujan-Barroso</name><affiliation wicri:level="1"><nlm:aff id="A1">Unit of Nutrition and Cancer. Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Nutrition and Cancer. Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation wicri:level="3"><nlm:aff id="A2">Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, Oxford</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><wicri:orgArea>Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford</wicri:orgArea></affiliation></author><author><name sortKey="Freisling, Heinz" sort="Freisling, Heinz" uniqKey="Freisling H" first="Heinz" last="Freisling">Heinz Freisling</name><affiliation wicri:level="1"><nlm:aff id="A3">Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Ferrari, Pietro" sort="Ferrari, Pietro" uniqKey="Ferrari P" first="Pietro" last="Ferrari">Pietro Ferrari</name><affiliation wicri:level="1"><nlm:aff id="A3">Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation wicri:level="1"><nlm:aff id="A4">Human Genetics Foundation (HuGeF), Torino, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Human Genetics Foundation (HuGeF), Torino</wicri:regionArea></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation wicri:level="1"><nlm:aff id="A5">Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><affiliation wicri:level="1"><nlm:aff id="A7">Inserm, CESP Centre for Research in Epidemiology and Population Health, U1018, Lifestyle, genes and health: integrative trans-generational epidemiology, F-94805, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, CESP Centre for Research in Epidemiology and Population Health, U1018, Lifestyle, genes and health: integrative trans-generational epidemiology, F-94805, Villejuif</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Univ Paris Sud, UMRS 1018, F-94805, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ Paris Sud, UMRS 1018, F-94805, Villejuif</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Gustave Roussy, F-94805, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Gustave Roussy, F-94805, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Fortner, Renee T" sort="Fortner, Renee T" uniqKey="Fortner R" first="Renée T." last="Fortner">Renée T. Fortner</name><affiliation wicri:level="1"><nlm:aff id="A10">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Ose, Jennifer" sort="Ose, Jennifer" uniqKey="Ose J" first="Jennifer" last="Ose">Jennifer Ose</name><affiliation wicri:level="1"><nlm:aff id="A10">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation wicri:level="1"><nlm:aff id="A11">Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal</wicri:regionArea></affiliation></author><author><name sortKey="Menendez, Virginia" sort="Menendez, Virginia" uniqKey="Menendez V" first="Virginia" last="Menéndez">Virginia Menéndez</name><affiliation wicri:level="1"><nlm:aff id="A12">Public Health Directorate, Asturias, Spain.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Espagne</country><wicri:regionArea>Public Health Directorate, Asturias</wicri:regionArea></affiliation></author><author><name sortKey="Sanchez Cantalejo, Emilio" sort="Sanchez Cantalejo, Emilio" uniqKey="Sanchez Cantalejo E" first="Emilio" last="Sánchez-Cantalejo">Emilio Sánchez-Cantalejo</name><affiliation wicri:level="1"><nlm:aff id="A13">CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiology and Public Health CIBERESP, Madrid</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A14">Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada</wicri:regionArea></affiliation></author><author><name sortKey="Chamosa, Saioa" sort="Chamosa, Saioa" uniqKey="Chamosa S" first="Saioa" last="Chamosa">Saioa Chamosa</name><affiliation wicri:level="1"><nlm:aff id="A15">Public Health Division of Gipuzkoa-BIODONOSTIA, Basque Regional Health Department, San Sebastian, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Public Health Division of Gipuzkoa-BIODONOSTIA, Basque Regional Health Department, San Sebastian</wicri:regionArea></affiliation></author><author><name sortKey="Huerta Casta O, Jose Maria" sort="Huerta Casta O, Jose Maria" uniqKey="Huerta Casta O J" first="José María" last="Huerta Casta O">José María Huerta Casta O</name><affiliation wicri:level="1"><nlm:aff id="A13">CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiology and Public Health CIBERESP, Madrid</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A16">Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Espagne</country><wicri:regionArea>Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia</wicri:regionArea></affiliation></author><author><name sortKey="Ardanaz, Eva" sort="Ardanaz, Eva" uniqKey="Ardanaz E" first="Eva" last="Ardanaz">Eva Ardanaz</name><affiliation wicri:level="1"><nlm:aff id="A13">CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiology and Public Health CIBERESP, Madrid</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A17">Navarra Public Health Institute, Pamplona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Navarra Public Health Institute, Pamplona</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A18">IdiSNA, Navarra Institute for Health Research, Pamplona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>IdiSNA, Navarra Institute for Health Research, Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="1"><nlm:aff id="A19">University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Cambridge School of Clinical Medicine, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Wareham, Nick" sort="Wareham, Nick" uniqKey="Wareham N" first="Nick" last="Wareham">Nick Wareham</name><affiliation wicri:level="1"><nlm:aff id="A20">Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, Oxford, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Merritt, Melissa A" sort="Merritt, Melissa A" uniqKey="Merritt M" first="Melissa A." last="Merritt">Melissa A. Merritt</name><affiliation wicri:level="1"><nlm:aff id="A21">Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J." last="Gunter">Marc J. Gunter</name><affiliation wicri:level="1"><nlm:aff id="A21">Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name><affiliation wicri:level="1"><nlm:aff id="A22">Hellenic Health Foundation, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A23">WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School</wicri:regionArea></affiliation></author><author><name sortKey="Papatesta, Eleni Maria" sort="Papatesta, Eleni Maria" uniqKey="Papatesta E" first="Eleni-Maria" last="Papatesta">Eleni-Maria Papatesta</name><affiliation wicri:level="1"><nlm:aff id="A22">Hellenic Health Foundation, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Klinaki, Eleni" sort="Klinaki, Eleni" uniqKey="Klinaki E" first="Eleni" last="Klinaki">Eleni Klinaki</name><affiliation wicri:level="1"><nlm:aff id="A22">Hellenic Health Foundation, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Saieva, Calogero" sort="Saieva, Calogero" uniqKey="Saieva C" first="Calogero" last="Saieva">Calogero Saieva</name><affiliation><nlm:aff id="A24">Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence- Italy</nlm:aff><wicri:noCountry code="subfield">Florence- Italy</wicri:noCountry></affiliation></author><author><name sortKey="Tagliabue, Giovanna" sort="Tagliabue, Giovanna" uniqKey="Tagliabue G" first="Giovanna" last="Tagliabue">Giovanna Tagliabue</name><affiliation wicri:level="1"><nlm:aff id="A25">Lombardy Cancer Registry Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Lombardy Cancer Registry Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano</wicri:regionArea></affiliation></author><author><name sortKey="Tumino, Rosario" sort="Tumino, Rosario" uniqKey="Tumino R" first="Rosario" last="Tumino">Rosario Tumino</name><affiliation><nlm:aff id="A26">Cancer Registry and Histopathology Unit, “Civic - M.P.Arezzo” Hospital, ASP Ragusa (Italy)</nlm:aff><wicri:noCountry code="subfield">ASP Ragusa (Italy)</wicri:noCountry></affiliation></author><author><name sortKey="Sacerdote, Carlotta" sort="Sacerdote, Carlotta" uniqKey="Sacerdote C" first="Carlotta" last="Sacerdote">Carlotta Sacerdote</name><affiliation wicri:level="1"><nlm:aff id="A27">Unit of Cancer Epidemiology, Citta' della Salute e della Scienza Hospital-University of Turin and Center for Cancer Prevention (CPO), Torino, Italy.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Italie</country><wicri:regionArea>Unit of Cancer Epidemiology, Citta' della Salute e della Scienza Hospital-University of Turin and Center for Cancer Prevention (CPO), Torino</wicri:regionArea></affiliation></author><author><name sortKey="Mattiello, Amalia" sort="Mattiello, Amalia" uniqKey="Mattiello A" first="Amalia" last="Mattiello">Amalia Mattiello</name><affiliation wicri:level="1"><nlm:aff id="A28">Dipartamiento di Medicina Clinica e Chirurgia Federico II University, Naples, Italy.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Italie</country><wicri:regionArea>Dipartamiento di Medicina Clinica e Chirurgia Federico II University, Naples</wicri:regionArea></affiliation></author><author><name sortKey="Bueno De Mesquita, H B" sort="Bueno De Mesquita, H B" uniqKey="Bueno De Mesquita H" first="H. B." last="Bueno-De-Mesquita">H. B. Bueno-De-Mesquita</name><affiliation wicri:level="1"><nlm:aff id="A21">Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A29">Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A30">Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A31">Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Malaisie</country><wicri:regionArea>Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur</wicri:regionArea></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name><affiliation wicri:level="1"><nlm:aff id="A21">Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A32">Department of Epidemiology, Julius Center for Health Sciences and Primary Care,University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Julius Center for Health Sciences and Primary Care,University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N. Charlotte" last="Onland-Moret">N. Charlotte Onland-Moret</name><affiliation wicri:level="1"><nlm:aff id="A33">Julius Center for Health Scienes and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Julius Center for Health Scienes and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Idahl, Annika" sort="Idahl, Annika" uniqKey="Idahl A" first="Annika" last="Idahl">Annika Idahl</name><affiliation wicri:level="1"><nlm:aff id="A34">Department of Clinical Sciences, Obstetrics and Gynecology Nutritional Research Umeå University, Umeå, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Obstetrics and Gynecology Nutritional Research Umeå University, Umeå</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A35">Department of Public Health and Clinical Medicine, Nutritional Research Umeå University, Umeå, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Public Health and Clinical Medicine, Nutritional Research Umeå University, Umeå</wicri:regionArea></affiliation></author><author><name sortKey="Lundin, Eva" sort="Lundin, Eva" uniqKey="Lundin E" first="Eva" last="Lundin">Eva Lundin</name><affiliation wicri:level="1"><nlm:aff id="A36">Department of Medical Biosciences, Pathology Umeå University, Umeå, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Biosciences, Pathology Umeå University, Umeå</wicri:regionArea></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation wicri:level="1"><nlm:aff id="A37">Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Norvège</country><wicri:regionArea>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A38">Department of Research, Cancer Registry of Norway, Oslo, Norway.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Norvège</country><wicri:regionArea>Department of Research, Cancer Registry of Norway, Oslo</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A40">Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Vesper, Hubert W" sort="Vesper, Hubert W" uniqKey="Vesper H" first="Hubert W." last="Vesper">Hubert W. Vesper</name><affiliation wicri:level="1"><nlm:aff id="A41">Centers for Disease Control and Prevention, Atlanta, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Centers for Disease Control and Prevention, Atlanta</wicri:regionArea></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation wicri:level="1"><nlm:aff id="A21">Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Duell, Eric J" sort="Duell, Eric J" uniqKey="Duell E" first="Eric J" last="Duell">Eric J. Duell</name><affiliation wicri:level="1"><nlm:aff id="A1">Unit of Nutrition and Cancer. Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Nutrition and Cancer. Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona</wicri:regionArea></affiliation></author></analytic><series><title level="j">International journal of cancer</title><idno type="ISSN">0020-7136</idno><idno type="eISSN">1097-0215</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Acrylamide was classified as ‘probably carcinogenic to humans (group 2A)’ by the International Agency for Research on Cancer. Epithelial ovarian cancer (EOC) is the fourth cause of cancer mortality in women. Five epidemiological studies have evaluated the association between EOC risk and dietary acrylamide intake assessed using food frequency questionnaires, and one nested case-control study evaluated hemoglobin adducts of acrylamide (HbAA) and its metabolite glycidamide (HbGA) and EOC risk; the results of these studies were inconsistent.</p></sec><sec id="S2"><title>Methods</title><p id="P2">A nested case-control study in non-smoking postmenopausal women (334 cases, 417 controls) was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association between HbAA, HbGA, HbAA+HbGA, and HbGA/HbAA and EOC and invasive serous EOC risk.</p></sec><sec id="S3"><title>Results</title><p id="P3">No overall associations were observed between biomarkers of acrylamide exposure analyzed in quintiles and EOC risk; however, positive associations were observed between some middle quintiles of HbGA and HbAA+HbGA. Elevated but non-statistically significant ORs for serous EOC were observed for HbGA and HbAA+HbGA (OR<sub>Q5</sub><italic><sub>vs</sub></italic><sub>Q1</sub>:1.91, 95%CI:0.96-3.81 and OR<sub>Q5</sub><italic><sub>vs</sub></italic><sub>Q1</sub>:1.90, 95%CI:0.94-3.83, respectively); however, no linear dose-response trends were observed.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">This EPIC nested case-control study failed to observe a clear association between biomarkers of acrylamide exposure and the risk of EOC or invasive serous EOC.</p></sec><sec id="S5"><title>Impact</title><p id="P5">It is unlikely that dietary acrylamide exposure increases ovarian cancer risk; however, additional studies with larger sample size should be performed to exclude any possible association with EOC risk.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0042124</journal-id><journal-id journal-id-type="pubmed-jr-id">4284</journal-id><journal-id journal-id-type="nlm-ta">Int J Cancer</journal-id><journal-id journal-id-type="iso-abbrev">Int. J. Cancer</journal-id><journal-title-group><journal-title>International journal of cancer</journal-title></journal-title-group><issn pub-type="ppub">0020-7136</issn><issn pub-type="epub">1097-0215</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26376083</article-id><article-id pub-id-type="pmc">4716289</article-id><article-id pub-id-type="doi">10.1002/ijc.29853</article-id><article-id pub-id-type="manuscript">EMS65968</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Acrylamide and glycidamide hemoglobin adducts and epithelial ovarian cancer: a nested case-control study in non-smoking postmenopausal women from the EPIC cohort</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Obón-Santacana</surname><given-names>Mireia</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Lujan-Barroso</surname><given-names>Leila</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Travis</surname><given-names>Ruth C.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Freisling</surname><given-names>Heinz</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Ferrari</surname><given-names>Pietro</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Severi</surname><given-names>Gianluca</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Baglietto</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Boutron-Ruault</surname><given-names>Marie-Christine</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Fortner</surname><given-names>Renée T.</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Ose</surname><given-names>Jennifer</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Boeing</surname><given-names>Heiner</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Menéndez</surname><given-names>Virginia</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Sánchez-Cantalejo</surname><given-names>Emilio</given-names></name><xref ref-type="aff" rid="A13">13</xref><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Chamosa</surname><given-names>Saioa</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Huerta Castaño</surname><given-names>José María</given-names></name><xref ref-type="aff" rid="A13">13</xref><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Ardanaz</surname><given-names>Eva</given-names></name><xref ref-type="aff" rid="A13">13</xref><xref ref-type="aff" rid="A17">17</xref><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Khaw</surname><given-names>Kay-Tee</given-names></name><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Wareham</surname><given-names>Nick</given-names></name><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Merritt</surname><given-names>Melissa A.</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Gunter</surname><given-names>Marc J.</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Trichopoulou</surname><given-names>Antonia</given-names></name><xref ref-type="aff" rid="A22">22</xref><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Papatesta</surname><given-names>Eleni-Maria</given-names></name><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Klinaki</surname><given-names>Eleni</given-names></name><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Saieva</surname><given-names>Calogero</given-names></name><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Tagliabue</surname><given-names>Giovanna</given-names></name><xref ref-type="aff" rid="A25">25</xref></contrib><contrib contrib-type="author"><name><surname>Tumino</surname><given-names>Rosario</given-names></name><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Sacerdote</surname><given-names>Carlotta</given-names></name><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Mattiello</surname><given-names>Amalia</given-names></name><xref ref-type="aff" rid="A28">28</xref></contrib><contrib contrib-type="author"><name><surname>Bueno-de-Mesquita</surname><given-names>H.B.</given-names></name><xref ref-type="aff" rid="A21">21</xref><xref ref-type="aff" rid="A29">29</xref><xref ref-type="aff" rid="A30">30</xref><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>Peeters</surname><given-names>Petra H.</given-names></name><xref ref-type="aff" rid="A21">21</xref><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Onland-Moret</surname><given-names>N. Charlotte</given-names></name><xref ref-type="aff" rid="A33">33</xref></contrib><contrib contrib-type="author"><name><surname>Idahl</surname><given-names>Annika</given-names></name><xref ref-type="aff" rid="A34">34</xref><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Lundin</surname><given-names>Eva</given-names></name><xref ref-type="aff" rid="A36">36</xref></contrib><contrib contrib-type="author"><name><surname>Weiderpass</surname><given-names>Elisabete</given-names></name><xref ref-type="aff" rid="A37">37</xref><xref ref-type="aff" rid="A38">38</xref><xref ref-type="aff" rid="A39">39</xref><xref ref-type="aff" rid="A40">40</xref></contrib><contrib contrib-type="author"><name><surname>Vesper</surname><given-names>Hubert W.</given-names></name><xref ref-type="aff" rid="A41">41</xref></contrib><contrib contrib-type="author"><name><surname>Riboli</surname><given-names>Elio</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Duell</surname><given-names>Eric J</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Unit of Nutrition and Cancer. Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain</aff><aff id="A2"><label>2</label>Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, Oxford</aff><aff id="A3"><label>3</label>Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon, France</aff><aff id="A4"><label>4</label>Human Genetics Foundation (HuGeF), Torino, Italy</aff><aff id="A5"><label>5</label>Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, Australia</aff><aff id="A6"><label>6</label>Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Australia</aff><aff id="A7"><label>7</label>Inserm, CESP Centre for Research in Epidemiology and Population Health, U1018, Lifestyle, genes and health: integrative trans-generational epidemiology, F-94805, Villejuif, France</aff><aff id="A8"><label>8</label>Univ Paris Sud, UMRS 1018, F-94805, Villejuif, France</aff><aff id="A9"><label>9</label>Gustave Roussy, F-94805, Villejuif, France</aff><aff id="A10"><label>10</label>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A11"><label>11</label>Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany</aff><aff id="A12"><label>12</label>Public Health Directorate, Asturias, Spain.</aff><aff id="A13"><label>13</label>CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain</aff><aff id="A14"><label>14</label>Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain</aff><aff id="A15"><label>15</label>Public Health Division of Gipuzkoa-BIODONOSTIA, Basque Regional Health Department, San Sebastian, Spain</aff><aff id="A16"><label>16</label>Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.</aff><aff id="A17"><label>17</label>Navarra Public Health Institute, Pamplona, Spain</aff><aff id="A18"><label>18</label>IdiSNA, Navarra Institute for Health Research, Pamplona, Spain</aff><aff id="A19"><label>19</label>University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom</aff><aff id="A20"><label>20</label>Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, Oxford, United Kingdom</aff><aff id="A21"><label>21</label>Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</aff><aff id="A22"><label>22</label>Hellenic Health Foundation, Athens, Greece</aff><aff id="A23"><label>23</label>WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Greece</aff><aff id="A24"><label>24</label>Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence- Italy</aff><aff id="A25"><label>25</label>Lombardy Cancer Registry Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy</aff><aff id="A26"><label>26</label>Cancer Registry and Histopathology Unit, “Civic - M.P.Arezzo” Hospital, ASP Ragusa (Italy)</aff><aff id="A27"><label>27</label>Unit of Cancer Epidemiology, Citta' della Salute e della Scienza Hospital-University of Turin and Center for Cancer Prevention (CPO), Torino, Italy.</aff><aff id="A28"><label>28</label>Dipartamiento di Medicina Clinica e Chirurgia Federico II University, Naples, Italy.</aff><aff id="A29"><label>29</label>Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</aff><aff id="A30"><label>30</label>Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands</aff><aff id="A31"><label>31</label>Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.</aff><aff id="A32"><label>32</label>Department of Epidemiology, Julius Center for Health Sciences and Primary Care,University Medical Center Utrecht, Utrecht, The Netherlands</aff><aff id="A33"><label>33</label>Julius Center for Health Scienes and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands</aff><aff id="A34"><label>34</label>Department of Clinical Sciences, Obstetrics and Gynecology Nutritional Research Umeå University, Umeå, Sweden</aff><aff id="A35"><label>35</label>Department of Public Health and Clinical Medicine, Nutritional Research Umeå University, Umeå, Sweden</aff><aff id="A36"><label>36</label>Department of Medical Biosciences, Pathology Umeå University, Umeå, Sweden</aff><aff id="A37"><label>37</label>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.</aff><aff id="A38"><label>38</label>Department of Research, Cancer Registry of Norway, Oslo, Norway.</aff><aff id="A39"><label>39</label>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A40"><label>40</label>Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland</aff><aff id="A41"><label>41</label>Centers for Disease Control and Prevention, Atlanta, USA</aff><author-notes><corresp id="CR1"><bold><underline>Correspondence to</underline>:</bold> Eric J. Duell, Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology, Avda Gran Via 199-203, 08907 L’Hospitalet del Llobregat, Barcelona, Spain. Phone: +34 93 260 7401; Fax: +34 93 260 7787. <email>eduell@iconcologia.net</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>17</day><month>11</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>01</day><month>10</month><year>2015</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>3</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>9</month><year>2016</year></pub-date><volume>138</volume><issue>5</issue><fpage>1129</fpage><lpage>1138</lpage><pmc-comment>elocation-id from pubmed: 10.1002/ijc.29853</pmc-comment>
<abstract><sec id="S1"><title>Background</title><p id="P1">Acrylamide was classified as ‘probably carcinogenic to humans (group 2A)’ by the International Agency for Research on Cancer. Epithelial ovarian cancer (EOC) is the fourth cause of cancer mortality in women. Five epidemiological studies have evaluated the association between EOC risk and dietary acrylamide intake assessed using food frequency questionnaires, and one nested case-control study evaluated hemoglobin adducts of acrylamide (HbAA) and its metabolite glycidamide (HbGA) and EOC risk; the results of these studies were inconsistent.</p></sec><sec id="S2"><title>Methods</title><p id="P2">A nested case-control study in non-smoking postmenopausal women (334 cases, 417 controls) was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association between HbAA, HbGA, HbAA+HbGA, and HbGA/HbAA and EOC and invasive serous EOC risk.</p></sec><sec id="S3"><title>Results</title><p id="P3">No overall associations were observed between biomarkers of acrylamide exposure analyzed in quintiles and EOC risk; however, positive associations were observed between some middle quintiles of HbGA and HbAA+HbGA. Elevated but non-statistically significant ORs for serous EOC were observed for HbGA and HbAA+HbGA (OR<sub>Q5</sub><italic><sub>vs</sub></italic><sub>Q1</sub>:1.91, 95%CI:0.96-3.81 and OR<sub>Q5</sub><italic><sub>vs</sub></italic><sub>Q1</sub>:1.90, 95%CI:0.94-3.83, respectively); however, no linear dose-response trends were observed.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">This EPIC nested case-control study failed to observe a clear association between biomarkers of acrylamide exposure and the risk of EOC or invasive serous EOC.</p></sec><sec id="S5"><title>Impact</title><p id="P5">It is unlikely that dietary acrylamide exposure increases ovarian cancer risk; however, additional studies with larger sample size should be performed to exclude any possible association with EOC risk.</p></sec></abstract><kwd-group><kwd>hemoglobin adduct</kwd><kwd>acrylamide</kwd><kwd>glycidamide</kwd><kwd>ovarian cancer</kwd><kwd>EPIC</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:26376083" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
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