Role of miR-155 in the regulation of lymphocyte immune function and disease
Identifieur interne : 001745 ( Pmc/Curation ); précédent : 001744; suivant : 001746Role of miR-155 in the regulation of lymphocyte immune function and disease
Auteurs : Nabila Seddiki [France] ; Vedran Brezar [France] ; Nicolas Ruffin [France] ; Yves Lévy [France] ; Sanjay Swaminathan [Australie]Source :
- Immunology [ 0019-2805 ] ; 2014.
Abstract
MicroRNAs (miRNAs) have emerged as critical regulators of gene expression within cells. One particular miRNA, miR-155, is highly expressed within lymphocytes (both B and T cells) and mediates a number of important roles. These include shaping the transcriptome of lymphoid cells that control diverse biological functions vital in adaptive immunity. The use of mice engineered to be deficient in miR-155, as well as the identification of endogenous targets of miR-155 in T cells by transcriptome-wide analysis, has helped to unravel the crucial role that this miRNA plays in fine tuning the regulation of lymphocyte subsets such as B cells, CD8+ and CD4+ T cells ranging from T helper type 1 (Th1), Th2, Th17 and regulatory T cells. In this review, we summarize what we have learned about miR-155 in the regulation of lymphocyte responses at the cellular and molecular levels and in particular, we focus on the recent findings showing that miR-155 shapes the balance between tolerance and immunity.
Url:
DOI: 10.1111/imm.12227
PubMed: 24303979
PubMed Central: 3992045
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<front><div type="abstract" xml:lang="en"><p>MicroRNAs (miRNAs) have emerged as critical regulators of gene expression within cells. One particular miRNA, miR-155, is highly expressed within lymphocytes (both B and T cells) and mediates a number of important roles. These include shaping the transcriptome of lymphoid cells that control diverse biological functions vital in adaptive immunity. The use of mice engineered to be deficient in miR-155, as well as the identification of endogenous targets of miR-155 in T cells by transcriptome-wide analysis, has helped to unravel the crucial role that this miRNA plays in fine tuning the regulation of lymphocyte subsets such as B cells, CD8<sup>+</sup>
and CD4<sup>+</sup>
T cells ranging from T helper type 1 (Th1), Th2, Th17 and regulatory T cells. In this review, we summarize what we have learned about miR-155 in the regulation of lymphocyte responses at the cellular and molecular levels and in particular, we focus on the recent findings showing that miR-155 shapes the balance between tolerance and immunity.</p>
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</front>
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<title-group><article-title>Role of miR-155 in the regulation of lymphocyte immune function and disease</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Seddiki</surname>
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<author-notes><corresp id="cor1">Correspondence: Dr Nabila Seddiki, INSERM U955 Equipe 16, Hôpital Henri Mondor Bâtiment Recherche, 1er étage, porte AA-072, 51, Ave du Maréchal de Lattre de Tassigny 94010 Créteil, France. Email: <email>nabila.seddiki@inserm.fr</email>
</corresp>
<fn><p>Senior author: Nabila Seddiki</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><month>5</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>10</day>
<month>4</month>
<year>2014</year>
</pub-date>
<volume>142</volume>
<issue>1</issue>
<fpage>32</fpage>
<lpage>38</lpage>
<history><date date-type="received"><day>04</day>
<month>11</month>
<year>2013</year>
</date>
<date date-type="rev-recd"><day>25</day>
<month>11</month>
<year>2013</year>
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<date date-type="accepted"><day>26</day>
<month>11</month>
<year>2013</year>
</date>
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<permissions><copyright-statement>© 2013 John Wiley & Sons Ltd <italic>Immunology</italic>
</copyright-statement>
<copyright-year>2013</copyright-year>
</permissions>
<abstract><p>MicroRNAs (miRNAs) have emerged as critical regulators of gene expression within cells. One particular miRNA, miR-155, is highly expressed within lymphocytes (both B and T cells) and mediates a number of important roles. These include shaping the transcriptome of lymphoid cells that control diverse biological functions vital in adaptive immunity. The use of mice engineered to be deficient in miR-155, as well as the identification of endogenous targets of miR-155 in T cells by transcriptome-wide analysis, has helped to unravel the crucial role that this miRNA plays in fine tuning the regulation of lymphocyte subsets such as B cells, CD8<sup>+</sup>
and CD4<sup>+</sup>
T cells ranging from T helper type 1 (Th1), Th2, Th17 and regulatory T cells. In this review, we summarize what we have learned about miR-155 in the regulation of lymphocyte responses at the cellular and molecular levels and in particular, we focus on the recent findings showing that miR-155 shapes the balance between tolerance and immunity.</p>
</abstract>
<kwd-group><kwd>experimental autoimmune encephalomyelitis/multiple sclerosis</kwd>
<kwd>regulatory T cells</kwd>
<kwd>T cells</kwd>
<kwd>T helper type 1/type2 cells</kwd>
</kwd-group>
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