Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade
Identifieur interne : 001733 ( Pmc/Curation ); précédent : 001732; suivant : 001734Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade
Auteurs : Kristen S. Purrington [États-Unis] ; Seth Slettedahl ; Manjeet K. Bolla ; Kyriaki Michailidou ; Kamila Czene ; Heli Nevanlinna ; Stig E. Bojesen [Danemark] ; Irene L. Andrulis ; Angela Cox ; Per Hall ; Jane Carpenter ; Drakoulis Yannoukakos [Grèce] ; Christopher A. Haiman [États-Unis] ; Peter A. Fasching [États-Unis] ; Arto Mannermaa [Finlande] ; Robert Winqvist [Finlande] ; Hermann Brenner [Allemagne] ; Annika Lindblom ; Georgia Chenevix-Trench [Australie] ; Javier Benitez [Espagne] ; Anthony Swerdlow [Royaume-Uni] ; Vessela Kristensen [Norvège] ; Pascal Guénel [France] ; Alfons Meindl [Allemagne] ; Hatef Darabi ; Mikael Eriksson ; Rainer Fagerholm ; Kristiina Aittom Ki ; Carl Blomqvist [Finlande] ; B Rge G. Nordestgaard [Danemark] ; Sune F. Nielsen ; Henrik Flyger [Danemark] ; Xianshu Wang [États-Unis] ; Curtis Olswold ; Janet E. Olson ; Anna Marie Mulligan [Canada] ; Julia A. Knight [Canada] ; Sandrine Tchatchou [Canada] ; Malcolm W. R. Reed ; Simon S. Cross [Royaume-Uni] ; Jianjun Liu [Singapour] ; Jingmei Li [Singapour] ; Keith Humphreys ; Christine Clarke [Australie] ; Rodney Scott [Australie] ; Florentia Fostira [Grèce] ; George Fountzilas [Grèce] ; Irene Konstantopoulou [Grèce] ; Brian E. Henderson [États-Unis] ; Fredrick Schumacher [États-Unis] ; Loic Le Marchand [États-Unis] ; Arif B. Ekici ; Arndt Hartmann [Allemagne] ; Matthias W. Beckmann ; Jaana M. Hartikainen [Finlande] ; Veli-Matti Kosma [Finlande] ; Vesa Kataja [Finlande] ; Arja Jukkola-Vuorinen ; Katri Pylk S [Finlande] ; Saila Kauppila [Finlande] ; Aida Karina Dieffenbach [Allemagne] ; Christa Stegmaier [Allemagne] ; Volker Arndt ; Sara Margolin [Suède] ; Rosemary Balleine [Australie] ; Jose Ignacio Arias Perez [Espagne] ; M. Pilar Zamora [Espagne] ; Primitiva Menéndez ; Alan Ashworth ; Michael Jones ; Nick Orr ; Patrick Arveux [France] ; Pierre Kerbrat [France] ; Thérèse Truong [France] ; Peter Bugert [Allemagne] ; Amanda E. Toland [États-Unis] ; Christine B. Ambrosone [États-Unis] ; France Labrèche [Canada] ; Mark S. Goldberg [Canada] ; Martine Dumont [Canada] ; Argyrios Ziogas [États-Unis] ; Eunjung Lee [États-Unis] ; Gillian S. Dite ; Carmel Apicella ; Melissa C. Southey ; Jirong Long [États-Unis] ; Martha Shrubsole [États-Unis] ; Sandra Deming-Halverson [États-Unis] ; Filomena Ficarazzi [Italie] ; Monica Barile [Italie] ; Paolo Peterlongo [Italie] ; Katarzyna Durda [Pologne] ; Katarzyna Jaworska-Bieniek [Pologne] ; Robert A. E. M. Tollenaar ; Caroline Seynaeve [Pays-Bas] ; Thomas Brüning [Allemagne] ; Yon-Dschun Ko [Allemagne] ; Carolien H. M. Van Deurzen [Pays-Bas] ; John W. M. Martens [Pays-Bas] ; Mieke Kriege [Pays-Bas] ; Jonine D. Figueroa [États-Unis] ; Stephen J. Chanock [États-Unis] ; Jolanta Lissowska [Pologne] ; Ian Tomlinson [Royaume-Uni] ; Michael J. Kerin [Irlande (pays)] ; Nicola Miller [Irlande (pays)] ; Andreas Schneeweiss [Allemagne] ; William J. Tapper [Royaume-Uni] ; Susan M. Gerty [Royaume-Uni] ; Lorraine Durcan [Royaume-Uni] ; Catriona Mclean [Australie] ; Roger L. Milne [Australie] ; Laura Baglietto [Australie] ; Isabel Dos Santos Silva [Royaume-Uni] ; Olivia Fletcher [Royaume-Uni] ; Nichola Johnson [Royaume-Uni] ; Laura J. Van'T Veer [Pays-Bas] ; Sten Cornelissen [Pays-Bas] ; Asta Försti [Suède] ; Diana Torres [Colombie] ; Thomas Rüdiger [Allemagne] ; Anja Rudolph ; Dieter Flesch-Janys [Allemagne] ; Stefan Nickels ; Caroline Weltens [Belgique] ; Giuseppe Floris [Belgique] ; Matthieu Moisse [Belgique] ; Joe Dennis ; Qin Wang ; Alison M. Dunning [Royaume-Uni] ; Mitul Shah [Royaume-Uni] ; Judith Brown ; Jacques Simard [Canada] ; Hoda Anton-Culver [États-Unis] ; Susan L. Neuhausen [États-Unis] ; John L. Hopper ; Natalia Bogdanova ; Thilo Dörk [Allemagne] ; Wei Zheng [États-Unis] ; Paolo Radice [Italie] ; Anna Jakubowska [Pologne] ; Jan Lubinski [Pologne] ; Peter Devillee [Pays-Bas] ; Hiltrud Brauch [Allemagne] ; Maartje Hooning [Pays-Bas] ; Montserrat García-Closas ; Elinor Sawyer [Royaume-Uni] ; Barbara Burwinkel [Allemagne] ; Frederick Marmee [Allemagne] ; Diana M. Eccles [Royaume-Uni] ; Graham G. Giles [Australie] ; Julian Peto [Royaume-Uni] ; Marjanka Schmidt [Pays-Bas] ; Annegien Broeks [Pays-Bas] ; Ute Hamann ; Jenny Chang-Claude ; Diether Lambrechts [Belgique] ; Paul D. P. Pharoah [Royaume-Uni] ; Douglas Easton [Royaume-Uni] ; V. Shane Pankratz ; Susan Slager ; Celine M. Vachon ; Fergus J. Couch [États-Unis]Source :
- Human Molecular Genetics [ 0964-6906 ] ; 2014.
Abstract
Mitotic index is an important component of histologic grade and has an etiologic role in breast tumorigenesis. Several small candidate gene studies have reported associations between variation in mitotic genes and breast cancer risk. We measured associations between 2156 single nucleotide polymorphisms (SNPs) from 194 mitotic genes and breast cancer risk, overall and by histologic grade, in the Breast Cancer Association Consortium (BCAC) iCOGS study (
Url:
DOI: 10.1093/hmg/ddu300
PubMed: 24927736
PubMed Central: 4204763
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Purrington</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Oncology</addr-line>,<institution>Wayne State University School of Medicine and Karmanos Cancer Institute</institution>,<addr-line>Detroit</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Slettedahl, Seth" sort="Slettedahl, Seth" uniqKey="Slettedahl S" first="Seth" last="Slettedahl">Seth Slettedahl</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="af6"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="af9"><addr-line>Department of Obstetrics and Gynecology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="af13"><addr-line>Copenhagen General Population Study</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Clinical Biochemistry</addr-line>,<institution>Herlev Hospital, Copenhagen University Hospital, University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="af15"><addr-line>Ontario Cancer Genetics Network</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af18"><addr-line>Department of Molecular Genetics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="af21"><addr-line>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="af6"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Carpenter, Jane" sort="Carpenter, Jane" uniqKey="Carpenter J" first="Jane" last="Carpenter">Jane Carpenter</name><affiliation><nlm:aff id="af23"><addr-line>Australian Breast Cancer Tissue Bank</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name><affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Molecular Diagnostics Laboratory INRASTES</addr-line>,<institution>National Centre for Scientific Research ‘Demokritos’</institution>,<addr-line>Athens</addr-line>,<country>Greece</country>,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="1"><nlm:aff id="af26"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="af27"><addr-line>University Breast Center Franconia, Department of Gynecology and Obstetrics</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af30"><addr-line>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology</addr-line>,<institution>University of California at Los Angeles</institution>,<addr-line>Los Angeles</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>School of Medicine, Institute of Clinical Medicine, Oncology, Cancer Center of Eastern Finland</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af32"><addr-line>Imaging Center, Department of Clinical Pathology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation wicri:level="1"><nlm:aff id="af34"><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu</addr-line>,<institution>University of Oulu, Oulu University Hospital/NordLab Oulu</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="af35"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af40"><institution>German Cancer Consortium (DKTK)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="af7"><addr-line>Department of Molecular Medicine and Surgery</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation wicri:level="1"><nlm:aff id="af41"><addr-line>Department of Genetics</addr-line>,<institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation wicri:level="1"><nlm:aff id="af43"><addr-line>Human Genetics Group, Human Cancer Genetics Program</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country>,</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af44"><addr-line>Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia</addr-line>,<country>Spain</country>,</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="af45"><addr-line>Division of Genetics and Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af46"><addr-line>Division of Breast Cancer Research</addr-line>,<institution>Institute of Cancer Research</institution>,<addr-line>Sutton</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation wicri:level="1"><nlm:aff id="af47"><addr-line>Department of Genetics, Institute for Cancer Research</addr-line>,<institution>Oslo University Hospital, Radiumhospitalet</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country>,</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af48"><addr-line>Faculty of Medicine (Faculty Division Ahus)</addr-line>,<institution>University of Oslo (UiO)</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country>,</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation wicri:level="1"><nlm:aff id="af49"><addr-line>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018</addr-line>,<institution>Environmental Epidemiology of Cancer</institution>,<addr-line>Villejuif</addr-line>,<country>France</country>,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af50"><institution>University Paris-Sud, UMRS 1018</institution>,<addr-line>Villejuif</addr-line>,<country>France</country>,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation wicri:level="1"><nlm:aff id="af51"><addr-line>Division of Gynaecology and Obstetrics</addr-line>,<institution>Technische Universität München</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation><nlm:aff id="af6"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Mikael" sort="Eriksson, Mikael" uniqKey="Eriksson M" first="Mikael" last="Eriksson">Mikael Eriksson</name><affiliation><nlm:aff id="af6"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Fagerholm, Rainer" sort="Fagerholm, Rainer" uniqKey="Fagerholm R" first="Rainer" last="Fagerholm">Rainer Fagerholm</name><affiliation><nlm:aff id="af10"><addr-line>Department of Obstetrics and Gynecology, Oncology and Clinical Genetics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="af11"><addr-line>Department of Clinical Genetics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Department of Oncology</addr-line>,<institution>University of Helsinki and Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Clinical Biochemistry</addr-line>,<institution>Herlev Hospital, Copenhagen University Hospital, University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F." last="Nielsen">Sune F. Nielsen</name><affiliation><nlm:aff id="af13"><addr-line>Copenhagen General Population Study</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation wicri:level="1"><nlm:aff id="af52"><addr-line>Department of Breast Surgery, Herlev Hospital</addr-line>,<institution>Copenhagen University Hospital</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Laboratory Medicine and Pathology</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Olswold, Curtis" sort="Olswold, Curtis" uniqKey="Olswold C" first="Curtis" last="Olswold">Curtis Olswold</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="af19"><addr-line>Department of Laboratory Medicine and Pathobiology</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af53"><addr-line>Laboratory Medicine Program</addr-line>,<institution>University Health Network</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="af16"><addr-line>Prosserman Centre for Health Research</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af20"><addr-line>Division of Epidemiology, Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tchatchou, Sandrine" sort="Tchatchou, Sandrine" uniqKey="Tchatchou S" first="Sandrine" last="Tchatchou">Sandrine Tchatchou</name><affiliation wicri:level="1"><nlm:aff id="af17"><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name><affiliation><nlm:aff id="af21"><addr-line>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation wicri:level="1"><nlm:aff id="af22"><addr-line>Academic Unit of Pathology, Department of Neuroscience</addr-line>,<institution>University of Sheffield</institution>,<addr-line>Sheffield</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation wicri:level="1"><nlm:aff id="af54"><addr-line>Human Genetics Division</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation wicri:level="1"><nlm:aff id="af54"><addr-line>Human Genetics Division</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name><affiliation><nlm:aff id="af6"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Clarke, Christine" sort="Clarke, Christine" uniqKey="Clarke C" first="Christine" last="Clarke">Christine Clarke</name><affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Westmead Institute for Cancer Research, Sydney Medical School Westmead</addr-line>,<institution>University of Sydney at the Westmead Millennium Institute</institution>,<addr-line>Westmead</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Scott, Rodney" sort="Scott, Rodney" uniqKey="Scott R" first="Rodney" last="Scott">Rodney Scott</name><affiliation wicri:level="1"><nlm:aff id="af55"><addr-line>Division of Genetics</addr-line>,<institution>Hunter Area Pathology Service and University of Newcastle</institution>,<addr-line>Newcastle</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fostira, Florentia" sort="Fostira, Florentia" uniqKey="Fostira F" first="Florentia" last="Fostira">Florentia Fostira</name><affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Molecular Diagnostics Laboratory INRASTES</addr-line>,<institution>National Centre for Scientific Research ‘Demokritos’</institution>,<addr-line>Athens</addr-line>,<country>Greece</country>,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fountzilas, George" sort="Fountzilas, George" uniqKey="Fountzilas G" first="George" last="Fountzilas">George Fountzilas</name><affiliation wicri:level="1"><nlm:aff id="af56"><addr-line>Department of Medical Oncology, “Papageorgiou” Hospital</addr-line>,<institution>Aristotle University of Thessaloniki School of Medicine</institution>,<addr-line>Thessaloniki</addr-line>,<country>Greece</country>,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Konstantopoulou, Irene" sort="Konstantopoulou, Irene" uniqKey="Konstantopoulou I" first="Irene" last="Konstantopoulou">Irene Konstantopoulou</name><affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Molecular Diagnostics Laboratory INRASTES</addr-line>,<institution>National Centre for Scientific Research ‘Demokritos’</institution>,<addr-line>Athens</addr-line>,<country>Greece</country>,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation wicri:level="1"><nlm:aff id="af26"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name><affiliation wicri:level="1"><nlm:aff id="af26"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="1"><nlm:aff id="af57"><addr-line>Epidemiology Program, Cancer Research Center</addr-line>,<institution>University of Hawaii</institution>,<addr-line>Honolulu</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="af28"><addr-line>Institute of Human Genetics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Hartmann, Arndt" sort="Hartmann, Arndt" uniqKey="Hartmann A" first="Arndt" last="Hartmann">Arndt Hartmann</name><affiliation wicri:level="1"><nlm:aff id="af29"><addr-line>Institute of Pathology</addr-line>,<institution>University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN</institution>,<addr-line>Erlangen</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="af27"><addr-line>University Breast Center Franconia, Department of Gynecology and Obstetrics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name><affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>School of Medicine, Institute of Clinical Medicine, Oncology, Cancer Center of Eastern Finland</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af32"><addr-line>Imaging Center, Department of Clinical Pathology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>School of Medicine, Institute of Clinical Medicine, Oncology, Cancer Center of Eastern Finland</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af32"><addr-line>Imaging Center, Department of Clinical Pathology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>School of Medicine, Institute of Clinical Medicine, Oncology, Cancer Center of Eastern Finland</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af33"><addr-line>Cancer Center</addr-line>,<institution>Kuopio University Hospital</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation><nlm:aff id="af58"><addr-line>Department of Oncology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation wicri:level="1"><nlm:aff id="af34"><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu</addr-line>,<institution>University of Oulu, Oulu University Hospital/NordLab Oulu</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kauppila, Saila" sort="Kauppila, Saila" uniqKey="Kauppila S" first="Saila" last="Kauppila">Saila Kauppila</name><affiliation wicri:level="1"><nlm:aff id="af59"><addr-line>Department of Pathology</addr-line>,<institution>Oulu University Hospital, University of Oulu</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name><affiliation><nlm:aff id="af35"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af40"><institution>German Cancer Consortium (DKTK)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation wicri:level="1"><nlm:aff id="af60"><institution>Saarland Cancer Registry</institution>,<addr-line>Saarbrücken</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="af35"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Department of Oncology–Pathology</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country>,</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Balleine, Rosemary" sort="Balleine, Rosemary" uniqKey="Balleine R" first="Rosemary" last="Balleine">Rosemary Balleine</name><affiliation wicri:level="1"><nlm:aff id="af62"><institution>Westmead Millenium Institute for Medical Research</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Arias Perez, Jose Ignacio" sort="Arias Perez, Jose Ignacio" uniqKey="Arias Perez J" first="Jose Ignacio" last="Arias Perez">Jose Ignacio Arias Perez</name><affiliation wicri:level="1"><nlm:aff id="af63"><addr-line>Servicio de Cirugía General y Especialidades</addr-line>,<institution>Hospital Monte Naranco</institution>,<addr-line>Oviedo</addr-line>,<country>Spain</country>,</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pilar Zamora, M" sort="Pilar Zamora, M" uniqKey="Pilar Zamora M" first="M." last="Pilar Zamora">M. Pilar Zamora</name><affiliation wicri:level="1"><nlm:aff id="af65"><addr-line>Servicio de Oncología Médica</addr-line>,<institution>Hospital Universitario La Paz</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country>,</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Menendez, Primitiva" sort="Menendez, Primitiva" uniqKey="Menendez P" first="Primitiva" last="Menéndez">Primitiva Menéndez</name><affiliation><nlm:aff id="af64"><addr-line>Servicio de Anatomía Patológica</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation><nlm:aff id="af66"><addr-line>Breakthrough Breast Cancer Research Centre and Division of Breast Cancer Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Jones, Michael" sort="Jones, Michael" uniqKey="Jones M" first="Michael" last="Jones">Michael Jones</name><affiliation><nlm:aff id="af45"><addr-line>Division of Genetics and Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation><nlm:aff id="af66"><addr-line>Breakthrough Breast Cancer Research Centre and Division of Breast Cancer Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Arveux, Patrick" sort="Arveux, Patrick" uniqKey="Arveux P" first="Patrick" last="Arveux">Patrick Arveux</name><affiliation wicri:level="1"><nlm:aff id="af68"><addr-line>Center Georges-Francois Leclerc</addr-line>,<institution>Registry of Gynecologic Tumors</institution>,<addr-line>Dijon</addr-line>,<country>France</country>,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kerbrat, Pierre" sort="Kerbrat, Pierre" uniqKey="Kerbrat P" first="Pierre" last="Kerbrat">Pierre Kerbrat</name><affiliation wicri:level="1"><nlm:aff id="af69"><institution>Centre Eugène Marquis, Department of Medical Oncology</institution>,<addr-line>Rennes</addr-line>,<country>France</country>,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation wicri:level="1"><nlm:aff id="af49"><addr-line>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018</addr-line>,<institution>Environmental Epidemiology of Cancer</institution>,<addr-line>Villejuif</addr-line>,<country>France</country>,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af50"><institution>University Paris-Sud, UMRS 1018</institution>,<addr-line>Villejuif</addr-line>,<country>France</country>,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bugert, Peter" sort="Bugert, Peter" uniqKey="Bugert P" first="Peter" last="Bugert">Peter Bugert</name><affiliation wicri:level="1"><nlm:aff id="af70"><institution>German Red Cross Blood Service of Baden-Württemberg-Hessen</institution>,<addr-line>Mannheim</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af71"><addr-line>Medical Faculty Mannheim, Institute of Transfusion Medicine and Immunology</addr-line>,<institution>Heidelberg University</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name><affiliation wicri:level="1"><nlm:aff id="af72"><addr-line>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center</addr-line>,<institution>The Ohio State University</institution>,<addr-line>Columbus</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ambrosone, Christine B" sort="Ambrosone, Christine B" uniqKey="Ambrosone C" first="Christine B." last="Ambrosone">Christine B. Ambrosone</name><affiliation wicri:level="1"><nlm:aff id="af73"><institution>Roswell Park Cancer Institute</institution>,<addr-line>Buffalo</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Labreche, France" sort="Labreche, France" uniqKey="Labreche F" first="France" last="Labrèche">France Labrèche</name><affiliation wicri:level="1"><nlm:aff id="af74"><addr-line>Department of Environmental & Occupational Health and of Social & Preventive Medicine</addr-line>,<institution>School of Public Health, Université de Montréal</institution>,<addr-line>Montreal</addr-line>,<country>Canada</country>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S." last="Goldberg">Mark S. Goldberg</name><affiliation wicri:level="1"><nlm:aff id="af75"><addr-line>Department of Medicine</addr-line>,<institution>McGill University</institution>,<addr-line>Montreal</addr-line>,<country>Canada</country>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af76"><addr-line>Division of Clinical Epidemiology</addr-line>,<institution>McGill University Health Centre, Royal Victoria Hospital</institution>,<addr-line>Montreal</addr-line>,<country>Canada</country>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name><affiliation wicri:level="1"><nlm:aff id="af77"><addr-line>Cancer Genomics Laboratory</addr-line>,<institution>Centre Hospitalier Universitaire de Québec Research Center and Laval University</institution>,<addr-line>Quebec City</addr-line>,<country>Canada</country>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name><affiliation wicri:level="1"><nlm:aff id="af78"><addr-line>Department of Epidemiology</addr-line>,<institution>University of California Irvine</institution>,<addr-line>Irvine</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Eunjung" sort="Lee, Eunjung" uniqKey="Lee E" first="Eunjung" last="Lee">Eunjung Lee</name><affiliation wicri:level="1"><nlm:aff id="af26"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dite, Gillian S" sort="Dite, Gillian S" uniqKey="Dite G" first="Gillian S." last="Dite">Gillian S. Dite</name><affiliation><nlm:aff id="af79"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff id="af79"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="af80"><addr-line>Department of Pathology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation wicri:level="1"><nlm:aff id="af82"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center</addr-line>,<institution>Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>,<addr-line>Nashville</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shrubsole, Martha" sort="Shrubsole, Martha" uniqKey="Shrubsole M" first="Martha" last="Shrubsole">Martha Shrubsole</name><affiliation wicri:level="1"><nlm:aff id="af72"><addr-line>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center</addr-line>,<institution>The Ohio State University</institution>,<addr-line>Columbus</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deming Halverson, Sandra" sort="Deming Halverson, Sandra" uniqKey="Deming Halverson S" first="Sandra" last="Deming-Halverson">Sandra Deming-Halverson</name><affiliation wicri:level="1"><nlm:aff id="af82"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center</addr-line>,<institution>Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>,<addr-line>Nashville</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ficarazzi, Filomena" sort="Ficarazzi, Filomena" uniqKey="Ficarazzi F" first="Filomena" last="Ficarazzi">Filomena Ficarazzi</name><affiliation wicri:level="1"><nlm:aff id="af83"><institution>Cogentech Cancer Genetic Test Laboratory</institution>,<addr-line>Milan</addr-line>,<country>Italy</country>,</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af84"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>,<addr-line>Milan</addr-line>,<country>Italy</country>,</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barile, Monica" sort="Barile, Monica" uniqKey="Barile M" first="Monica" last="Barile">Monica Barile</name><affiliation wicri:level="1"><nlm:aff id="af85"><addr-line>Division of Cancer Prevention and Genetics</addr-line>,<institution>Istituto Europeo di Oncologia (IEO)</institution>,<addr-line>Milan</addr-line>,<country>Italy</country>,</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation wicri:level="1"><nlm:aff id="af84"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>,<addr-line>Milan</addr-line>,<country>Italy</country>,</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation wicri:level="1"><nlm:aff id="af86"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country>,</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jaworska Bieniek, Katarzyna" sort="Jaworska Bieniek, Katarzyna" uniqKey="Jaworska Bieniek K" first="Katarzyna" last="Jaworska-Bieniek">Katarzyna Jaworska-Bieniek</name><affiliation wicri:level="1"><nlm:aff id="af86"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country>,</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name><affiliation><nlm:aff id="af87"><addr-line>Department of Surgical Oncology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation wicri:level="1"><nlm:aff id="af89"><addr-line>Family Cancer Clinic, Department of Medical Oncology</addr-line>,<institution>Erasmus MC-Daniel den Hoed Cancer Centrer</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation wicri:level="1"><nlm:aff id="af90"><institution>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA)</institution>,<addr-line>Bochum</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name><affiliation wicri:level="1"><nlm:aff id="af91"><addr-line>Department of Internal Medicine</addr-line>,<institution>Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus</institution>,<addr-line>Bonn</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Deurzen, Carolien H M" sort="Van Deurzen, Carolien H M" uniqKey="Van Deurzen C" first="Carolien H. M." last="Van Deurzen">Carolien H. M. Van Deurzen</name><affiliation wicri:level="1"><nlm:aff id="af96"><addr-line>Department of Pathology</addr-line>,<institution>Erasmus University Medical Center</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Martens, John W M" sort="Martens, John W M" uniqKey="Martens J" first="John W. M." last="Martens">John W. M. Martens</name><affiliation wicri:level="1"><nlm:aff id="af97"><addr-line>Department of Medical Oncology</addr-line>,<institution>Erasmus MC Cancer Institute</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kriege, Mieke" sort="Kriege, Mieke" uniqKey="Kriege M" first="Mieke" last="Kriege">Mieke Kriege</name><affiliation wicri:level="1"><nlm:aff id="af97"><addr-line>Department of Medical Oncology</addr-line>,<institution>Erasmus MC Cancer Institute</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D." last="Figueroa">Jonine D. Figueroa</name><affiliation wicri:level="1"><nlm:aff id="af98"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="1"><nlm:aff id="af98"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation wicri:level="1"><nlm:aff id="af99"><addr-line>Department of Cancer Epidemiology and Prevention</addr-line>,<institution>M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country>,</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation wicri:level="1"><nlm:aff id="af100"><addr-line>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kerin, Michael J" sort="Kerin, Michael J" uniqKey="Kerin M" first="Michael J." last="Kerin">Michael J. Kerin</name><affiliation wicri:level="1"><nlm:aff id="af101"><addr-line>Clinical Science Institute</addr-line>,<institution>University Hospital Galway</institution>,<addr-line>Galway</addr-line>,<country>Ireland</country>,</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation wicri:level="1"><nlm:aff id="af101"><addr-line>Clinical Science Institute</addr-line>,<institution>University Hospital Galway</institution>,<addr-line>Galway</addr-line>,<country>Ireland</country>,</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name><affiliation><nlm:aff id="af102"><addr-line>Department of Obstetrics and Gynecology</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af103"><addr-line>National Center for Tumor Diseases</addr-line>,<institution>University of Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tapper, William J" sort="Tapper, William J" uniqKey="Tapper W" first="William J." last="Tapper">William J. Tapper</name><affiliation wicri:level="1"><nlm:aff id="af104"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gerty, Susan M" sort="Gerty, Susan M" uniqKey="Gerty S" first="Susan M." last="Gerty">Susan M. Gerty</name><affiliation wicri:level="1"><nlm:aff id="af104"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Durcan, Lorraine" sort="Durcan, Lorraine" uniqKey="Durcan L" first="Lorraine" last="Durcan">Lorraine Durcan</name><affiliation wicri:level="1"><nlm:aff id="af104"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name><affiliation wicri:level="1"><nlm:aff id="af105"><addr-line>Anatomical Pathology</addr-line>,<institution>The Alfred Hospital</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation wicri:level="1"><nlm:aff id="af81"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af106"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>The Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation wicri:level="1"><nlm:aff id="af81"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af106"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>The Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos Santos Silva">Isabel Dos Santos Silva</name><affiliation wicri:level="1"><nlm:aff id="af107"><addr-line>Non-communicable Disease Epidemiology Department</addr-line>,<institution>London School of Hygiene and Tropical Medicine</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation wicri:level="1"><nlm:aff id="af67"><addr-line>Breakthrough Breast Cancer Research Centre</addr-line>,<institution>The Institute of Cancer Research</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation wicri:level="1"><nlm:aff id="af67"><addr-line>Breakthrough Breast Cancer Research Centre</addr-line>,<institution>The Institute of Cancer Research</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van T Veer, Laura J" sort="Van T Veer, Laura J" uniqKey="Van T Veer L" first="Laura J." last="Van'T Veer">Laura J. Van'T Veer</name><affiliation wicri:level="1"><nlm:aff id="af108"><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cornelissen, Sten" sort="Cornelissen, Sten" uniqKey="Cornelissen S" first="Sten" last="Cornelissen">Sten Cornelissen</name><affiliation wicri:level="1"><nlm:aff id="af108"><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Forsti, Asta" sort="Forsti, Asta" uniqKey="Forsti A" first="Asta" last="Försti">Asta Försti</name><affiliation><nlm:aff id="af37"><addr-line>Division of Molecular Genetic Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af109"><addr-line>Center for Primary Health Care Research</addr-line>,<institution>University of Lund</institution>,<addr-line>Malmö</addr-line>,<country>Sweden</country>,</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name><affiliation><nlm:aff id="af36"><addr-line>Molecular Genetics of Breast Cancer</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af110"><addr-line>Institute of Human Genetics</addr-line>,<institution>Pontificia University Javeriana</institution>,<addr-line>Bogota</addr-line>,<country>Colombia</country>,</nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rudiger, Thomas" sort="Rudiger, Thomas" uniqKey="Rudiger T" first="Thomas" last="Rüdiger">Thomas Rüdiger</name><affiliation wicri:level="1"><nlm:aff id="af111"><addr-line>Institute of Pathology</addr-line>,<institution>Städtisches Klinikum Karlsruhe</institution>,<addr-line>Karlsruhe</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="af38"><addr-line>Division of Cancer Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation wicri:level="1"><nlm:aff id="af112"><addr-line>Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology</addr-line>,<institution>University Clinic Hamburg-Eppendorf</institution>,<addr-line>Hamburg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nickels, Stefan" sort="Nickels, Stefan" uniqKey="Nickels S" first="Stefan" last="Nickels">Stefan Nickels</name><affiliation><nlm:aff id="af38"><addr-line>Division of Cancer Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Weltens, Caroline" sort="Weltens, Caroline" uniqKey="Weltens C" first="Caroline" last="Weltens">Caroline Weltens</name><affiliation wicri:level="1"><nlm:aff id="af113"><institution>Universital Hospital Gasthuisberg</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Floris, Giuseppe" sort="Floris, Giuseppe" uniqKey="Floris G" first="Giuseppe" last="Floris">Giuseppe Floris</name><affiliation wicri:level="1"><nlm:aff id="af113"><institution>Universital Hospital Gasthuisberg</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Moisse, Matthieu" sort="Moisse, Matthieu" uniqKey="Moisse M" first="Matthieu" last="Moisse">Matthieu Moisse</name><affiliation wicri:level="1"><nlm:aff id="af114"><addr-line>Laboratory for Translational Genetics, Department of Oncology</addr-line>,<institution>University of Leuven</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af115"><institution>Vesalius Research Center (VRC), VIB</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation wicri:level="1"><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name><affiliation wicri:level="1"><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brown, Judith" sort="Brown, Judith" uniqKey="Brown J" first="Judith" last="Brown">Judith Brown</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation wicri:level="1"><nlm:aff id="af77"><addr-line>Cancer Genomics Laboratory</addr-line>,<institution>Centre Hospitalier Universitaire de Québec Research Center and Laval University</institution>,<addr-line>Quebec City</addr-line>,<country>Canada</country>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation wicri:level="1"><nlm:aff id="af78"><addr-line>Department of Epidemiology</addr-line>,<institution>University of California Irvine</institution>,<addr-line>Irvine</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation wicri:level="1"><nlm:aff id="af116"><institution>Beckman Research Institute of City of Hope</institution>,<addr-line>Duarte</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="af79"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia" sort="Bogdanova, Natalia" uniqKey="Bogdanova N" first="Natalia" last="Bogdanova">Natalia Bogdanova</name><affiliation><nlm:aff id="af117"><addr-line>Department of Radiation Oncology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation wicri:level="1"><nlm:aff id="af118"><addr-line>Department of Obstetrics and Gynaecology</addr-line>,<institution>Hannover Medical School</institution>,<addr-line>Hannover</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation wicri:level="1"><nlm:aff id="af82"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center</addr-line>,<institution>Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>,<addr-line>Nashville</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af119"><addr-line>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine</addr-line>,<institution>Fondazione IRCCS Istituto Nazionale dei Tumori (INT)</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation wicri:level="1"><nlm:aff id="af86"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country>,</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation wicri:level="1"><nlm:aff id="af86"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country>,</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Devillee, Peter" sort="Devillee, Peter" uniqKey="Devillee P" first="Peter" last="Devillee">Peter Devillee</name><affiliation wicri:level="1"><nlm:aff id="af88"><addr-line>Department of Human Genetics & Department of Pathology</addr-line>,<institution>Leiden University Medical Center</institution>,<addr-line>Leiden</addr-line>,<country>The Netherlands</country>,</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation wicri:level="1"><nlm:aff id="af94"><institution>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology</institution>,<addr-line>Stuttgart</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af95"><institution>University of Tübingen</institution>,<addr-line>Tübingen</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hooning, Maartje" sort="Hooning, Maartje" uniqKey="Hooning M" first="Maartje" last="Hooning">Maartje Hooning</name><affiliation wicri:level="1"><nlm:aff id="af97"><addr-line>Department of Medical Oncology</addr-line>,<institution>Erasmus MC Cancer Institute</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="af66"><addr-line>Breakthrough Breast Cancer Research Centre and Division of Breast Cancer Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor" sort="Sawyer, Elinor" uniqKey="Sawyer E" first="Elinor" last="Sawyer">Elinor Sawyer</name><affiliation wicri:level="1"><nlm:aff id="af120"><addr-line>Division of Cancer Studies</addr-line>,<institution>Kings College London, Guy’s Hospital</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="af102"><addr-line>Department of Obstetrics and Gynecology</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af39"><addr-line>Molecular Epidemiology Group</addr-line>,<institution>German Cancer Research Center (DKFZ)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Marmee, Frederick" sort="Marmee, Frederick" uniqKey="Marmee F" first="Frederick" last="Marmee">Frederick Marmee</name><affiliation><nlm:aff id="af102"><addr-line>Department of Obstetrics and Gynecology</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af103"><addr-line>National Center for Tumor Diseases</addr-line>,<institution>University of Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eccles, Diana M" sort="Eccles, Diana M" uniqKey="Eccles D" first="Diana M." last="Eccles">Diana M. Eccles</name><affiliation wicri:level="1"><nlm:aff id="af104"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation wicri:level="1"><nlm:aff id="af81"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af106"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>The Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation wicri:level="1"><nlm:aff id="af107"><addr-line>Non-communicable Disease Epidemiology Department</addr-line>,<institution>London School of Hygiene and Tropical Medicine</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Marjanka" sort="Schmidt, Marjanka" uniqKey="Schmidt M" first="Marjanka" last="Schmidt">Marjanka Schmidt</name><affiliation wicri:level="1"><nlm:aff id="af108"><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation wicri:level="1"><nlm:aff id="af108"><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="af36"><addr-line>Molecular Genetics of Breast Cancer</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="af38"><addr-line>Division of Cancer Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation wicri:level="1"><nlm:aff id="af114"><addr-line>Laboratory for Translational Genetics, Department of Oncology</addr-line>,<institution>University of Leuven</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af115"><institution>Vesalius Research Center (VRC), VIB</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Easton, Douglas" sort="Easton, Douglas" uniqKey="Easton D" first="Douglas" last="Easton">Douglas Easton</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pankratz, V Shane" sort="Pankratz, V Shane" uniqKey="Pankratz V" first="V. Shane" last="Pankratz">V. Shane Pankratz</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Slager, Susan" sort="Slager, Susan" uniqKey="Slager S" first="Susan" last="Slager">Susan Slager</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine M" sort="Vachon, Celine M" uniqKey="Vachon C" first="Celine M." last="Vachon">Celine M. Vachon</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Laboratory Medicine and Pathology</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24927736</idno><idno type="pmc">4204763</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204763</idno><idno type="RBID">PMC:4204763</idno><idno type="doi">10.1093/hmg/ddu300</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001873</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001873</idno><idno type="wicri:Area/Pmc/Curation">001733</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001733</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade</title><author><name sortKey="Purrington, Kristen S" sort="Purrington, Kristen S" uniqKey="Purrington K" first="Kristen S." last="Purrington">Kristen S. Purrington</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Oncology</addr-line>,<institution>Wayne State University School of Medicine and Karmanos Cancer Institute</institution>,<addr-line>Detroit</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Slettedahl, Seth" sort="Slettedahl, Seth" uniqKey="Slettedahl S" first="Seth" last="Slettedahl">Seth Slettedahl</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="af6"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="af9"><addr-line>Department of Obstetrics and Gynecology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="af13"><addr-line>Copenhagen General Population Study</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Clinical Biochemistry</addr-line>,<institution>Herlev Hospital, Copenhagen University Hospital, University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="af15"><addr-line>Ontario Cancer Genetics Network</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af18"><addr-line>Department of Molecular Genetics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="af21"><addr-line>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="af6"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Carpenter, Jane" sort="Carpenter, Jane" uniqKey="Carpenter J" first="Jane" last="Carpenter">Jane Carpenter</name><affiliation><nlm:aff id="af23"><addr-line>Australian Breast Cancer Tissue Bank</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name><affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Molecular Diagnostics Laboratory INRASTES</addr-line>,<institution>National Centre for Scientific Research ‘Demokritos’</institution>,<addr-line>Athens</addr-line>,<country>Greece</country>,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="1"><nlm:aff id="af26"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="af27"><addr-line>University Breast Center Franconia, Department of Gynecology and Obstetrics</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af30"><addr-line>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology</addr-line>,<institution>University of California at Los Angeles</institution>,<addr-line>Los Angeles</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>School of Medicine, Institute of Clinical Medicine, Oncology, Cancer Center of Eastern Finland</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af32"><addr-line>Imaging Center, Department of Clinical Pathology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation wicri:level="1"><nlm:aff id="af34"><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu</addr-line>,<institution>University of Oulu, Oulu University Hospital/NordLab Oulu</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="af35"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af40"><institution>German Cancer Consortium (DKTK)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="af7"><addr-line>Department of Molecular Medicine and Surgery</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation wicri:level="1"><nlm:aff id="af41"><addr-line>Department of Genetics</addr-line>,<institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation wicri:level="1"><nlm:aff id="af43"><addr-line>Human Genetics Group, Human Cancer Genetics Program</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country>,</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af44"><addr-line>Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia</addr-line>,<country>Spain</country>,</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="af45"><addr-line>Division of Genetics and Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af46"><addr-line>Division of Breast Cancer Research</addr-line>,<institution>Institute of Cancer Research</institution>,<addr-line>Sutton</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation wicri:level="1"><nlm:aff id="af47"><addr-line>Department of Genetics, Institute for Cancer Research</addr-line>,<institution>Oslo University Hospital, Radiumhospitalet</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country>,</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af48"><addr-line>Faculty of Medicine (Faculty Division Ahus)</addr-line>,<institution>University of Oslo (UiO)</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country>,</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation wicri:level="1"><nlm:aff id="af49"><addr-line>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018</addr-line>,<institution>Environmental Epidemiology of Cancer</institution>,<addr-line>Villejuif</addr-line>,<country>France</country>,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af50"><institution>University Paris-Sud, UMRS 1018</institution>,<addr-line>Villejuif</addr-line>,<country>France</country>,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation wicri:level="1"><nlm:aff id="af51"><addr-line>Division of Gynaecology and Obstetrics</addr-line>,<institution>Technische Universität München</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation><nlm:aff id="af6"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Mikael" sort="Eriksson, Mikael" uniqKey="Eriksson M" first="Mikael" last="Eriksson">Mikael Eriksson</name><affiliation><nlm:aff id="af6"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Fagerholm, Rainer" sort="Fagerholm, Rainer" uniqKey="Fagerholm R" first="Rainer" last="Fagerholm">Rainer Fagerholm</name><affiliation><nlm:aff id="af10"><addr-line>Department of Obstetrics and Gynecology, Oncology and Clinical Genetics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="af11"><addr-line>Department of Clinical Genetics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Department of Oncology</addr-line>,<institution>University of Helsinki and Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Clinical Biochemistry</addr-line>,<institution>Herlev Hospital, Copenhagen University Hospital, University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F." last="Nielsen">Sune F. Nielsen</name><affiliation><nlm:aff id="af13"><addr-line>Copenhagen General Population Study</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation wicri:level="1"><nlm:aff id="af52"><addr-line>Department of Breast Surgery, Herlev Hospital</addr-line>,<institution>Copenhagen University Hospital</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Laboratory Medicine and Pathology</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Olswold, Curtis" sort="Olswold, Curtis" uniqKey="Olswold C" first="Curtis" last="Olswold">Curtis Olswold</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="af19"><addr-line>Department of Laboratory Medicine and Pathobiology</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af53"><addr-line>Laboratory Medicine Program</addr-line>,<institution>University Health Network</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="af16"><addr-line>Prosserman Centre for Health Research</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af20"><addr-line>Division of Epidemiology, Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tchatchou, Sandrine" sort="Tchatchou, Sandrine" uniqKey="Tchatchou S" first="Sandrine" last="Tchatchou">Sandrine Tchatchou</name><affiliation wicri:level="1"><nlm:aff id="af17"><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name><affiliation><nlm:aff id="af21"><addr-line>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation wicri:level="1"><nlm:aff id="af22"><addr-line>Academic Unit of Pathology, Department of Neuroscience</addr-line>,<institution>University of Sheffield</institution>,<addr-line>Sheffield</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation wicri:level="1"><nlm:aff id="af54"><addr-line>Human Genetics Division</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation wicri:level="1"><nlm:aff id="af54"><addr-line>Human Genetics Division</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name><affiliation><nlm:aff id="af6"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Clarke, Christine" sort="Clarke, Christine" uniqKey="Clarke C" first="Christine" last="Clarke">Christine Clarke</name><affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Westmead Institute for Cancer Research, Sydney Medical School Westmead</addr-line>,<institution>University of Sydney at the Westmead Millennium Institute</institution>,<addr-line>Westmead</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Scott, Rodney" sort="Scott, Rodney" uniqKey="Scott R" first="Rodney" last="Scott">Rodney Scott</name><affiliation wicri:level="1"><nlm:aff id="af55"><addr-line>Division of Genetics</addr-line>,<institution>Hunter Area Pathology Service and University of Newcastle</institution>,<addr-line>Newcastle</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fostira, Florentia" sort="Fostira, Florentia" uniqKey="Fostira F" first="Florentia" last="Fostira">Florentia Fostira</name><affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Molecular Diagnostics Laboratory INRASTES</addr-line>,<institution>National Centre for Scientific Research ‘Demokritos’</institution>,<addr-line>Athens</addr-line>,<country>Greece</country>,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fountzilas, George" sort="Fountzilas, George" uniqKey="Fountzilas G" first="George" last="Fountzilas">George Fountzilas</name><affiliation wicri:level="1"><nlm:aff id="af56"><addr-line>Department of Medical Oncology, “Papageorgiou” Hospital</addr-line>,<institution>Aristotle University of Thessaloniki School of Medicine</institution>,<addr-line>Thessaloniki</addr-line>,<country>Greece</country>,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Konstantopoulou, Irene" sort="Konstantopoulou, Irene" uniqKey="Konstantopoulou I" first="Irene" last="Konstantopoulou">Irene Konstantopoulou</name><affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Molecular Diagnostics Laboratory INRASTES</addr-line>,<institution>National Centre for Scientific Research ‘Demokritos’</institution>,<addr-line>Athens</addr-line>,<country>Greece</country>,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation wicri:level="1"><nlm:aff id="af26"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name><affiliation wicri:level="1"><nlm:aff id="af26"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="1"><nlm:aff id="af57"><addr-line>Epidemiology Program, Cancer Research Center</addr-line>,<institution>University of Hawaii</institution>,<addr-line>Honolulu</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="af28"><addr-line>Institute of Human Genetics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Hartmann, Arndt" sort="Hartmann, Arndt" uniqKey="Hartmann A" first="Arndt" last="Hartmann">Arndt Hartmann</name><affiliation wicri:level="1"><nlm:aff id="af29"><addr-line>Institute of Pathology</addr-line>,<institution>University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN</institution>,<addr-line>Erlangen</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="af27"><addr-line>University Breast Center Franconia, Department of Gynecology and Obstetrics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name><affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>School of Medicine, Institute of Clinical Medicine, Oncology, Cancer Center of Eastern Finland</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af32"><addr-line>Imaging Center, Department of Clinical Pathology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>School of Medicine, Institute of Clinical Medicine, Oncology, Cancer Center of Eastern Finland</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af32"><addr-line>Imaging Center, Department of Clinical Pathology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>School of Medicine, Institute of Clinical Medicine, Oncology, Cancer Center of Eastern Finland</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af33"><addr-line>Cancer Center</addr-line>,<institution>Kuopio University Hospital</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation><nlm:aff id="af58"><addr-line>Department of Oncology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation wicri:level="1"><nlm:aff id="af34"><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu</addr-line>,<institution>University of Oulu, Oulu University Hospital/NordLab Oulu</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kauppila, Saila" sort="Kauppila, Saila" uniqKey="Kauppila S" first="Saila" last="Kauppila">Saila Kauppila</name><affiliation wicri:level="1"><nlm:aff id="af59"><addr-line>Department of Pathology</addr-line>,<institution>Oulu University Hospital, University of Oulu</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name><affiliation><nlm:aff id="af35"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af40"><institution>German Cancer Consortium (DKTK)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation wicri:level="1"><nlm:aff id="af60"><institution>Saarland Cancer Registry</institution>,<addr-line>Saarbrücken</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="af35"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Department of Oncology–Pathology</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country>,</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Balleine, Rosemary" sort="Balleine, Rosemary" uniqKey="Balleine R" first="Rosemary" last="Balleine">Rosemary Balleine</name><affiliation wicri:level="1"><nlm:aff id="af62"><institution>Westmead Millenium Institute for Medical Research</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Arias Perez, Jose Ignacio" sort="Arias Perez, Jose Ignacio" uniqKey="Arias Perez J" first="Jose Ignacio" last="Arias Perez">Jose Ignacio Arias Perez</name><affiliation wicri:level="1"><nlm:aff id="af63"><addr-line>Servicio de Cirugía General y Especialidades</addr-line>,<institution>Hospital Monte Naranco</institution>,<addr-line>Oviedo</addr-line>,<country>Spain</country>,</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pilar Zamora, M" sort="Pilar Zamora, M" uniqKey="Pilar Zamora M" first="M." last="Pilar Zamora">M. Pilar Zamora</name><affiliation wicri:level="1"><nlm:aff id="af65"><addr-line>Servicio de Oncología Médica</addr-line>,<institution>Hospital Universitario La Paz</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country>,</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Menendez, Primitiva" sort="Menendez, Primitiva" uniqKey="Menendez P" first="Primitiva" last="Menéndez">Primitiva Menéndez</name><affiliation><nlm:aff id="af64"><addr-line>Servicio de Anatomía Patológica</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation><nlm:aff id="af66"><addr-line>Breakthrough Breast Cancer Research Centre and Division of Breast Cancer Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Jones, Michael" sort="Jones, Michael" uniqKey="Jones M" first="Michael" last="Jones">Michael Jones</name><affiliation><nlm:aff id="af45"><addr-line>Division of Genetics and Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation><nlm:aff id="af66"><addr-line>Breakthrough Breast Cancer Research Centre and Division of Breast Cancer Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Arveux, Patrick" sort="Arveux, Patrick" uniqKey="Arveux P" first="Patrick" last="Arveux">Patrick Arveux</name><affiliation wicri:level="1"><nlm:aff id="af68"><addr-line>Center Georges-Francois Leclerc</addr-line>,<institution>Registry of Gynecologic Tumors</institution>,<addr-line>Dijon</addr-line>,<country>France</country>,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kerbrat, Pierre" sort="Kerbrat, Pierre" uniqKey="Kerbrat P" first="Pierre" last="Kerbrat">Pierre Kerbrat</name><affiliation wicri:level="1"><nlm:aff id="af69"><institution>Centre Eugène Marquis, Department of Medical Oncology</institution>,<addr-line>Rennes</addr-line>,<country>France</country>,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation wicri:level="1"><nlm:aff id="af49"><addr-line>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018</addr-line>,<institution>Environmental Epidemiology of Cancer</institution>,<addr-line>Villejuif</addr-line>,<country>France</country>,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af50"><institution>University Paris-Sud, UMRS 1018</institution>,<addr-line>Villejuif</addr-line>,<country>France</country>,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bugert, Peter" sort="Bugert, Peter" uniqKey="Bugert P" first="Peter" last="Bugert">Peter Bugert</name><affiliation wicri:level="1"><nlm:aff id="af70"><institution>German Red Cross Blood Service of Baden-Württemberg-Hessen</institution>,<addr-line>Mannheim</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af71"><addr-line>Medical Faculty Mannheim, Institute of Transfusion Medicine and Immunology</addr-line>,<institution>Heidelberg University</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name><affiliation wicri:level="1"><nlm:aff id="af72"><addr-line>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center</addr-line>,<institution>The Ohio State University</institution>,<addr-line>Columbus</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ambrosone, Christine B" sort="Ambrosone, Christine B" uniqKey="Ambrosone C" first="Christine B." last="Ambrosone">Christine B. Ambrosone</name><affiliation wicri:level="1"><nlm:aff id="af73"><institution>Roswell Park Cancer Institute</institution>,<addr-line>Buffalo</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Labreche, France" sort="Labreche, France" uniqKey="Labreche F" first="France" last="Labrèche">France Labrèche</name><affiliation wicri:level="1"><nlm:aff id="af74"><addr-line>Department of Environmental & Occupational Health and of Social & Preventive Medicine</addr-line>,<institution>School of Public Health, Université de Montréal</institution>,<addr-line>Montreal</addr-line>,<country>Canada</country>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S." last="Goldberg">Mark S. Goldberg</name><affiliation wicri:level="1"><nlm:aff id="af75"><addr-line>Department of Medicine</addr-line>,<institution>McGill University</institution>,<addr-line>Montreal</addr-line>,<country>Canada</country>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af76"><addr-line>Division of Clinical Epidemiology</addr-line>,<institution>McGill University Health Centre, Royal Victoria Hospital</institution>,<addr-line>Montreal</addr-line>,<country>Canada</country>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name><affiliation wicri:level="1"><nlm:aff id="af77"><addr-line>Cancer Genomics Laboratory</addr-line>,<institution>Centre Hospitalier Universitaire de Québec Research Center and Laval University</institution>,<addr-line>Quebec City</addr-line>,<country>Canada</country>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name><affiliation wicri:level="1"><nlm:aff id="af78"><addr-line>Department of Epidemiology</addr-line>,<institution>University of California Irvine</institution>,<addr-line>Irvine</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Eunjung" sort="Lee, Eunjung" uniqKey="Lee E" first="Eunjung" last="Lee">Eunjung Lee</name><affiliation wicri:level="1"><nlm:aff id="af26"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dite, Gillian S" sort="Dite, Gillian S" uniqKey="Dite G" first="Gillian S." last="Dite">Gillian S. Dite</name><affiliation><nlm:aff id="af79"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff id="af79"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="af80"><addr-line>Department of Pathology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation wicri:level="1"><nlm:aff id="af82"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center</addr-line>,<institution>Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>,<addr-line>Nashville</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shrubsole, Martha" sort="Shrubsole, Martha" uniqKey="Shrubsole M" first="Martha" last="Shrubsole">Martha Shrubsole</name><affiliation wicri:level="1"><nlm:aff id="af72"><addr-line>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center</addr-line>,<institution>The Ohio State University</institution>,<addr-line>Columbus</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deming Halverson, Sandra" sort="Deming Halverson, Sandra" uniqKey="Deming Halverson S" first="Sandra" last="Deming-Halverson">Sandra Deming-Halverson</name><affiliation wicri:level="1"><nlm:aff id="af82"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center</addr-line>,<institution>Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>,<addr-line>Nashville</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ficarazzi, Filomena" sort="Ficarazzi, Filomena" uniqKey="Ficarazzi F" first="Filomena" last="Ficarazzi">Filomena Ficarazzi</name><affiliation wicri:level="1"><nlm:aff id="af83"><institution>Cogentech Cancer Genetic Test Laboratory</institution>,<addr-line>Milan</addr-line>,<country>Italy</country>,</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af84"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>,<addr-line>Milan</addr-line>,<country>Italy</country>,</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barile, Monica" sort="Barile, Monica" uniqKey="Barile M" first="Monica" last="Barile">Monica Barile</name><affiliation wicri:level="1"><nlm:aff id="af85"><addr-line>Division of Cancer Prevention and Genetics</addr-line>,<institution>Istituto Europeo di Oncologia (IEO)</institution>,<addr-line>Milan</addr-line>,<country>Italy</country>,</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation wicri:level="1"><nlm:aff id="af84"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>,<addr-line>Milan</addr-line>,<country>Italy</country>,</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation wicri:level="1"><nlm:aff id="af86"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country>,</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jaworska Bieniek, Katarzyna" sort="Jaworska Bieniek, Katarzyna" uniqKey="Jaworska Bieniek K" first="Katarzyna" last="Jaworska-Bieniek">Katarzyna Jaworska-Bieniek</name><affiliation wicri:level="1"><nlm:aff id="af86"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country>,</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name><affiliation><nlm:aff id="af87"><addr-line>Department of Surgical Oncology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation wicri:level="1"><nlm:aff id="af89"><addr-line>Family Cancer Clinic, Department of Medical Oncology</addr-line>,<institution>Erasmus MC-Daniel den Hoed Cancer Centrer</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation wicri:level="1"><nlm:aff id="af90"><institution>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA)</institution>,<addr-line>Bochum</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name><affiliation wicri:level="1"><nlm:aff id="af91"><addr-line>Department of Internal Medicine</addr-line>,<institution>Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus</institution>,<addr-line>Bonn</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Deurzen, Carolien H M" sort="Van Deurzen, Carolien H M" uniqKey="Van Deurzen C" first="Carolien H. M." last="Van Deurzen">Carolien H. M. Van Deurzen</name><affiliation wicri:level="1"><nlm:aff id="af96"><addr-line>Department of Pathology</addr-line>,<institution>Erasmus University Medical Center</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Martens, John W M" sort="Martens, John W M" uniqKey="Martens J" first="John W. M." last="Martens">John W. M. Martens</name><affiliation wicri:level="1"><nlm:aff id="af97"><addr-line>Department of Medical Oncology</addr-line>,<institution>Erasmus MC Cancer Institute</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kriege, Mieke" sort="Kriege, Mieke" uniqKey="Kriege M" first="Mieke" last="Kriege">Mieke Kriege</name><affiliation wicri:level="1"><nlm:aff id="af97"><addr-line>Department of Medical Oncology</addr-line>,<institution>Erasmus MC Cancer Institute</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D." last="Figueroa">Jonine D. Figueroa</name><affiliation wicri:level="1"><nlm:aff id="af98"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="1"><nlm:aff id="af98"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation wicri:level="1"><nlm:aff id="af99"><addr-line>Department of Cancer Epidemiology and Prevention</addr-line>,<institution>M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country>,</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation wicri:level="1"><nlm:aff id="af100"><addr-line>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kerin, Michael J" sort="Kerin, Michael J" uniqKey="Kerin M" first="Michael J." last="Kerin">Michael J. Kerin</name><affiliation wicri:level="1"><nlm:aff id="af101"><addr-line>Clinical Science Institute</addr-line>,<institution>University Hospital Galway</institution>,<addr-line>Galway</addr-line>,<country>Ireland</country>,</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation wicri:level="1"><nlm:aff id="af101"><addr-line>Clinical Science Institute</addr-line>,<institution>University Hospital Galway</institution>,<addr-line>Galway</addr-line>,<country>Ireland</country>,</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name><affiliation><nlm:aff id="af102"><addr-line>Department of Obstetrics and Gynecology</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af103"><addr-line>National Center for Tumor Diseases</addr-line>,<institution>University of Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tapper, William J" sort="Tapper, William J" uniqKey="Tapper W" first="William J." last="Tapper">William J. Tapper</name><affiliation wicri:level="1"><nlm:aff id="af104"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gerty, Susan M" sort="Gerty, Susan M" uniqKey="Gerty S" first="Susan M." last="Gerty">Susan M. Gerty</name><affiliation wicri:level="1"><nlm:aff id="af104"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Durcan, Lorraine" sort="Durcan, Lorraine" uniqKey="Durcan L" first="Lorraine" last="Durcan">Lorraine Durcan</name><affiliation wicri:level="1"><nlm:aff id="af104"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name><affiliation wicri:level="1"><nlm:aff id="af105"><addr-line>Anatomical Pathology</addr-line>,<institution>The Alfred Hospital</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation wicri:level="1"><nlm:aff id="af81"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af106"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>The Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation wicri:level="1"><nlm:aff id="af81"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af106"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>The Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos Santos Silva">Isabel Dos Santos Silva</name><affiliation wicri:level="1"><nlm:aff id="af107"><addr-line>Non-communicable Disease Epidemiology Department</addr-line>,<institution>London School of Hygiene and Tropical Medicine</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation wicri:level="1"><nlm:aff id="af67"><addr-line>Breakthrough Breast Cancer Research Centre</addr-line>,<institution>The Institute of Cancer Research</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation wicri:level="1"><nlm:aff id="af67"><addr-line>Breakthrough Breast Cancer Research Centre</addr-line>,<institution>The Institute of Cancer Research</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van T Veer, Laura J" sort="Van T Veer, Laura J" uniqKey="Van T Veer L" first="Laura J." last="Van'T Veer">Laura J. Van'T Veer</name><affiliation wicri:level="1"><nlm:aff id="af108"><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cornelissen, Sten" sort="Cornelissen, Sten" uniqKey="Cornelissen S" first="Sten" last="Cornelissen">Sten Cornelissen</name><affiliation wicri:level="1"><nlm:aff id="af108"><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Forsti, Asta" sort="Forsti, Asta" uniqKey="Forsti A" first="Asta" last="Försti">Asta Försti</name><affiliation><nlm:aff id="af37"><addr-line>Division of Molecular Genetic Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af109"><addr-line>Center for Primary Health Care Research</addr-line>,<institution>University of Lund</institution>,<addr-line>Malmö</addr-line>,<country>Sweden</country>,</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name><affiliation><nlm:aff id="af36"><addr-line>Molecular Genetics of Breast Cancer</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af110"><addr-line>Institute of Human Genetics</addr-line>,<institution>Pontificia University Javeriana</institution>,<addr-line>Bogota</addr-line>,<country>Colombia</country>,</nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rudiger, Thomas" sort="Rudiger, Thomas" uniqKey="Rudiger T" first="Thomas" last="Rüdiger">Thomas Rüdiger</name><affiliation wicri:level="1"><nlm:aff id="af111"><addr-line>Institute of Pathology</addr-line>,<institution>Städtisches Klinikum Karlsruhe</institution>,<addr-line>Karlsruhe</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="af38"><addr-line>Division of Cancer Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation wicri:level="1"><nlm:aff id="af112"><addr-line>Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology</addr-line>,<institution>University Clinic Hamburg-Eppendorf</institution>,<addr-line>Hamburg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nickels, Stefan" sort="Nickels, Stefan" uniqKey="Nickels S" first="Stefan" last="Nickels">Stefan Nickels</name><affiliation><nlm:aff id="af38"><addr-line>Division of Cancer Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Weltens, Caroline" sort="Weltens, Caroline" uniqKey="Weltens C" first="Caroline" last="Weltens">Caroline Weltens</name><affiliation wicri:level="1"><nlm:aff id="af113"><institution>Universital Hospital Gasthuisberg</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Floris, Giuseppe" sort="Floris, Giuseppe" uniqKey="Floris G" first="Giuseppe" last="Floris">Giuseppe Floris</name><affiliation wicri:level="1"><nlm:aff id="af113"><institution>Universital Hospital Gasthuisberg</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Moisse, Matthieu" sort="Moisse, Matthieu" uniqKey="Moisse M" first="Matthieu" last="Moisse">Matthieu Moisse</name><affiliation wicri:level="1"><nlm:aff id="af114"><addr-line>Laboratory for Translational Genetics, Department of Oncology</addr-line>,<institution>University of Leuven</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af115"><institution>Vesalius Research Center (VRC), VIB</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation wicri:level="1"><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name><affiliation wicri:level="1"><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brown, Judith" sort="Brown, Judith" uniqKey="Brown J" first="Judith" last="Brown">Judith Brown</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation wicri:level="1"><nlm:aff id="af77"><addr-line>Cancer Genomics Laboratory</addr-line>,<institution>Centre Hospitalier Universitaire de Québec Research Center and Laval University</institution>,<addr-line>Quebec City</addr-line>,<country>Canada</country>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation wicri:level="1"><nlm:aff id="af78"><addr-line>Department of Epidemiology</addr-line>,<institution>University of California Irvine</institution>,<addr-line>Irvine</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation wicri:level="1"><nlm:aff id="af116"><institution>Beckman Research Institute of City of Hope</institution>,<addr-line>Duarte</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="af79"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia" sort="Bogdanova, Natalia" uniqKey="Bogdanova N" first="Natalia" last="Bogdanova">Natalia Bogdanova</name><affiliation><nlm:aff id="af117"><addr-line>Department of Radiation Oncology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation wicri:level="1"><nlm:aff id="af118"><addr-line>Department of Obstetrics and Gynaecology</addr-line>,<institution>Hannover Medical School</institution>,<addr-line>Hannover</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation wicri:level="1"><nlm:aff id="af82"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center</addr-line>,<institution>Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>,<addr-line>Nashville</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af119"><addr-line>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine</addr-line>,<institution>Fondazione IRCCS Istituto Nazionale dei Tumori (INT)</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation wicri:level="1"><nlm:aff id="af86"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country>,</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation wicri:level="1"><nlm:aff id="af86"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country>,</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Devillee, Peter" sort="Devillee, Peter" uniqKey="Devillee P" first="Peter" last="Devillee">Peter Devillee</name><affiliation wicri:level="1"><nlm:aff id="af88"><addr-line>Department of Human Genetics & Department of Pathology</addr-line>,<institution>Leiden University Medical Center</institution>,<addr-line>Leiden</addr-line>,<country>The Netherlands</country>,</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation wicri:level="1"><nlm:aff id="af94"><institution>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology</institution>,<addr-line>Stuttgart</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af95"><institution>University of Tübingen</institution>,<addr-line>Tübingen</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hooning, Maartje" sort="Hooning, Maartje" uniqKey="Hooning M" first="Maartje" last="Hooning">Maartje Hooning</name><affiliation wicri:level="1"><nlm:aff id="af97"><addr-line>Department of Medical Oncology</addr-line>,<institution>Erasmus MC Cancer Institute</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="af66"><addr-line>Breakthrough Breast Cancer Research Centre and Division of Breast Cancer Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor" sort="Sawyer, Elinor" uniqKey="Sawyer E" first="Elinor" last="Sawyer">Elinor Sawyer</name><affiliation wicri:level="1"><nlm:aff id="af120"><addr-line>Division of Cancer Studies</addr-line>,<institution>Kings College London, Guy’s Hospital</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="af102"><addr-line>Department of Obstetrics and Gynecology</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af39"><addr-line>Molecular Epidemiology Group</addr-line>,<institution>German Cancer Research Center (DKFZ)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Marmee, Frederick" sort="Marmee, Frederick" uniqKey="Marmee F" first="Frederick" last="Marmee">Frederick Marmee</name><affiliation><nlm:aff id="af102"><addr-line>Department of Obstetrics and Gynecology</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af103"><addr-line>National Center for Tumor Diseases</addr-line>,<institution>University of Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eccles, Diana M" sort="Eccles, Diana M" uniqKey="Eccles D" first="Diana M." last="Eccles">Diana M. Eccles</name><affiliation wicri:level="1"><nlm:aff id="af104"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation wicri:level="1"><nlm:aff id="af81"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af106"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>The Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation wicri:level="1"><nlm:aff id="af107"><addr-line>Non-communicable Disease Epidemiology Department</addr-line>,<institution>London School of Hygiene and Tropical Medicine</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Marjanka" sort="Schmidt, Marjanka" uniqKey="Schmidt M" first="Marjanka" last="Schmidt">Marjanka Schmidt</name><affiliation wicri:level="1"><nlm:aff id="af108"><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation wicri:level="1"><nlm:aff id="af108"><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="af36"><addr-line>Molecular Genetics of Breast Cancer</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="af38"><addr-line>Division of Cancer Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation wicri:level="1"><nlm:aff id="af114"><addr-line>Laboratory for Translational Genetics, Department of Oncology</addr-line>,<institution>University of Leuven</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af115"><institution>Vesalius Research Center (VRC), VIB</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Easton, Douglas" sort="Easton, Douglas" uniqKey="Easton D" first="Douglas" last="Easton">Douglas Easton</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pankratz, V Shane" sort="Pankratz, V Shane" uniqKey="Pankratz V" first="V. Shane" last="Pankratz">V. Shane Pankratz</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Slager, Susan" sort="Slager, Susan" uniqKey="Slager S" first="Susan" last="Slager">Susan Slager</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine M" sort="Vachon, Celine M" uniqKey="Vachon C" first="Celine M." last="Vachon">Celine M. Vachon</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Laboratory Medicine and Pathology</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Human Molecular Genetics</title><idno type="ISSN">0964-6906</idno><idno type="eISSN">1460-2083</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Mitotic index is an important component of histologic grade and has an etiologic role in breast tumorigenesis. Several small candidate gene studies have reported associations between variation in mitotic genes and breast cancer risk. We measured associations between 2156 single nucleotide polymorphisms (SNPs) from 194 mitotic genes and breast cancer risk, overall and by histologic grade, in the Breast Cancer Association Consortium (BCAC) iCOGS study (<italic>n</italic> = 39 067 cases; <italic>n</italic> = 42 106 controls). SNPs in <italic>TACC2</italic> [rs17550038: odds ratio (OR) = 1.24, 95% confidence interval (CI) 1.16–1.33, <italic>P</italic> = 4.2 × 10<sup>−10</sup>) and <italic>EIF3H</italic> (rs799890: OR = 1.07, 95% CI 1.04–1.11, <italic>P</italic> = 8.7 × 10<sup>−6</sup>) were significantly associated with risk of low-grade breast cancer. The <italic>TACC2</italic> signal was retained (rs17550038: OR = 1.15, 95% CI 1.07–1.23, <italic>P</italic> = 7.9 × 10<sup>−5</sup>) after adjustment for breast cancer risk SNPs in the nearby <italic>FGFR2</italic> gene, suggesting that <italic>TACC2</italic> is a novel, independent genome-wide significant genetic risk locus for low-grade breast cancer. While no SNPs were individually associated with high-grade disease, a pathway-level gene set analysis showed that variation across the 194 mitotic genes was associated with high-grade breast cancer risk (<italic>P</italic> = 2.1 × 10<sup>−3</sup>). These observations will provide insight into the contribution of mitotic defects to histological grade and the etiology of breast cancer.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Hum Mol Genet</journal-id><journal-id journal-id-type="iso-abbrev">Hum. Mol. Genet</journal-id><journal-id journal-id-type="publisher-id">hmg</journal-id><journal-id journal-id-type="hwp">hmg</journal-id><journal-title-group><journal-title>Human Molecular Genetics</journal-title></journal-title-group><issn pub-type="ppub">0964-6906</issn><issn pub-type="epub">1460-2083</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24927736</article-id><article-id pub-id-type="pmc">4204763</article-id><article-id pub-id-type="doi">10.1093/hmg/ddu300</article-id><article-id pub-id-type="publisher-id">ddu300</article-id><article-categories><subj-group subj-group-type="heading"><subject>Association Studies Articles</subject></subj-group></article-categories><title-group><article-title>Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade</article-title></title-group><contrib-group><contrib 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contrib-type="author"><name><surname>Tapper</surname><given-names>William J.</given-names></name><xref ref-type="aff" rid="af104">104</xref></contrib><contrib contrib-type="author"><name><surname>Gerty</surname><given-names>Susan M.</given-names></name><xref ref-type="aff" rid="af104">104</xref></contrib><contrib contrib-type="author"><name><surname>Durcan</surname><given-names>Lorraine</given-names></name><xref ref-type="aff" rid="af104">104</xref></contrib><contrib contrib-type="author"><name><surname>Mclean</surname><given-names>Catriona</given-names></name><xref ref-type="aff" rid="af105">105</xref></contrib><contrib contrib-type="author"><name><surname>Milne</surname><given-names>Roger L.</given-names></name><xref ref-type="aff" rid="af81">81</xref><xref ref-type="aff" rid="af106">106</xref></contrib><contrib contrib-type="author"><name><surname>Baglietto</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="af81">81</xref><xref ref-type="aff" rid="af106">106</xref></contrib><contrib contrib-type="author"><name><surname>dos Santos Silva</surname><given-names>Isabel</given-names></name><xref ref-type="aff" rid="af107">107</xref></contrib><contrib contrib-type="author"><name><surname>Fletcher</surname><given-names>Olivia</given-names></name><xref ref-type="aff" rid="af67">67</xref></contrib><contrib contrib-type="author"><name><surname>Johnson</surname><given-names>Nichola</given-names></name><xref ref-type="aff" rid="af67">67</xref></contrib><contrib contrib-type="author"><name><surname>Van'T Veer</surname><given-names>Laura J.</given-names></name><xref ref-type="aff" rid="af108">108</xref></contrib><contrib contrib-type="author"><name><surname>Cornelissen</surname><given-names>Sten</given-names></name><xref ref-type="aff" rid="af108">108</xref></contrib><contrib contrib-type="author"><name><surname>Försti</surname><given-names>Asta</given-names></name><xref ref-type="aff" rid="af37">37</xref><xref ref-type="aff" rid="af109">109</xref></contrib><contrib contrib-type="author"><name><surname>Torres</surname><given-names>Diana</given-names></name><xref ref-type="aff" rid="af36">36</xref><xref ref-type="aff" rid="af110">110</xref></contrib><contrib contrib-type="author"><name><surname>Rüdiger</surname><given-names>Thomas</given-names></name><xref ref-type="aff" rid="af111">111</xref></contrib><contrib contrib-type="author"><name><surname>Rudolph</surname><given-names>Anja</given-names></name><xref ref-type="aff" rid="af38">38</xref></contrib><contrib contrib-type="author"><name><surname>Flesch-Janys</surname><given-names>Dieter</given-names></name><xref ref-type="aff" rid="af112">112</xref></contrib><contrib contrib-type="author"><name><surname>Nickels</surname><given-names>Stefan</given-names></name><xref ref-type="aff" rid="af38">38</xref></contrib><contrib contrib-type="author"><name><surname>Weltens</surname><given-names>Caroline</given-names></name><xref ref-type="aff" rid="af113">113</xref></contrib><contrib contrib-type="author"><name><surname>Floris</surname><given-names>Giuseppe</given-names></name><xref ref-type="aff" rid="af113">113</xref></contrib><contrib contrib-type="author"><name><surname>Moisse</surname><given-names>Matthieu</given-names></name><xref ref-type="aff" rid="af114">114</xref><xref ref-type="aff" rid="af115">115</xref></contrib><contrib contrib-type="author"><name><surname>Dennis</surname><given-names>Joe</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Qin</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Dunning</surname><given-names>Alison M.</given-names></name><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Shah</surname><given-names>Mitul</given-names></name><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Brown</surname><given-names>Judith</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Simard</surname><given-names>Jacques</given-names></name><xref ref-type="aff" rid="af77">77</xref></contrib><contrib contrib-type="author"><name><surname>Anton-Culver</surname><given-names>Hoda</given-names></name><xref ref-type="aff" rid="af78">78</xref></contrib><contrib contrib-type="author"><name><surname>Neuhausen</surname><given-names>Susan L.</given-names></name><xref ref-type="aff" rid="af116">116</xref></contrib><contrib contrib-type="author"><name><surname>Hopper</surname><given-names>John L.</given-names></name><xref ref-type="aff" rid="af79">79</xref></contrib><contrib contrib-type="author"><name><surname>Bogdanova</surname><given-names>Natalia</given-names></name><xref ref-type="aff" rid="af117">117</xref></contrib><contrib contrib-type="author"><name><surname>Dörk</surname><given-names>Thilo</given-names></name><xref ref-type="aff" rid="af118">118</xref></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Wei</given-names></name><xref ref-type="aff" rid="af82">82</xref></contrib><contrib contrib-type="author"><name><surname>Radice</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="af119">119</xref></contrib><contrib contrib-type="author"><name><surname>Jakubowska</surname><given-names>Anna</given-names></name><xref ref-type="aff" rid="af86">86</xref></contrib><contrib contrib-type="author"><name><surname>Lubinski</surname><given-names>Jan</given-names></name><xref ref-type="aff" rid="af86">86</xref></contrib><contrib contrib-type="author"><name><surname>Devillee</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="af88">88</xref></contrib><contrib contrib-type="author"><name><surname>Brauch</surname><given-names>Hiltrud</given-names></name><xref ref-type="aff" rid="af94">94</xref><xref ref-type="aff" rid="af95">95</xref></contrib><contrib contrib-type="author"><name><surname>Hooning</surname><given-names>Maartje</given-names></name><xref ref-type="aff" rid="af97">97</xref></contrib><contrib contrib-type="author"><name><surname>García-Closas</surname><given-names>Montserrat</given-names></name><xref ref-type="aff" rid="af66">66</xref></contrib><contrib contrib-type="author"><name><surname>Sawyer</surname><given-names>Elinor</given-names></name><xref ref-type="aff" rid="af120">120</xref></contrib><contrib contrib-type="author"><name><surname>Burwinkel</surname><given-names>Barbara</given-names></name><xref ref-type="aff" rid="af102">102</xref><xref ref-type="aff" rid="af39">39</xref></contrib><contrib contrib-type="author"><name><surname>Marmee</surname><given-names>Frederick</given-names></name><xref ref-type="aff" rid="af102">102</xref><xref ref-type="aff" rid="af103">103</xref></contrib><contrib contrib-type="author"><name><surname>Eccles</surname><given-names>Diana M.</given-names></name><xref ref-type="aff" rid="af104">104</xref></contrib><contrib contrib-type="author"><name><surname>Giles</surname><given-names>Graham G.</given-names></name><xref ref-type="aff" rid="af81">81</xref><xref ref-type="aff" rid="af106">106</xref></contrib><contrib contrib-type="author"><name><surname>Peto</surname><given-names>Julian</given-names></name><xref ref-type="aff" rid="af107">107</xref></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>Marjanka</given-names></name><xref ref-type="aff" rid="af108">108</xref></contrib><contrib contrib-type="author"><name><surname>Broeks</surname><given-names>Annegien</given-names></name><xref ref-type="aff" rid="af108">108</xref></contrib><contrib contrib-type="author"><name><surname>Hamann</surname><given-names>Ute</given-names></name><xref ref-type="aff" rid="af36">36</xref></contrib><contrib contrib-type="author"><name><surname>Chang-Claude</surname><given-names>Jenny</given-names></name><xref ref-type="aff" rid="af38">38</xref></contrib><contrib contrib-type="author"><name><surname>Lambrechts</surname><given-names>Diether</given-names></name><xref ref-type="aff" rid="af114">114</xref><xref ref-type="aff" rid="af115">115</xref></contrib><contrib contrib-type="author"><name><surname>Pharoah</surname><given-names>Paul D.P.</given-names></name><xref ref-type="aff" rid="af4">4</xref><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas</given-names></name><xref ref-type="aff" rid="af4">4</xref><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Pankratz</surname><given-names>V. Shane</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Slager</surname><given-names>Susan</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Vachon</surname><given-names>Celine M.</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Couch</surname><given-names>Fergus J.</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><aff id="af1"><label>1</label><addr-line>Department of Health Sciences Research</addr-line>,</aff><aff id="af2"><label>2</label><addr-line>Department of Laboratory Medicine and Pathology</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester</addr-line>,<country>USA</country>,</aff><aff id="af3"><label>3</label><addr-line>Department of Oncology</addr-line>,<institution>Wayne State University School of Medicine and Karmanos Cancer Institute</institution>,<addr-line>Detroit</addr-line>,<country>USA</country>,</aff><aff id="af4"><label>4</label><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</aff><aff id="af5"><label>5</label><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</aff><aff id="af6"><label>6</label><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,</aff><aff id="af7"><label>7</label><addr-line>Department of Molecular Medicine and Surgery</addr-line>,</aff><aff id="af8"><label>8</label><addr-line>Department of Oncology–Pathology</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country>,</aff><aff id="af9"><label>9</label><addr-line>Department of Obstetrics and Gynecology</addr-line>,</aff><aff id="af10"><label>10</label><addr-line>Department of Obstetrics and Gynecology, Oncology and Clinical Genetics</addr-line>,</aff><aff id="af11"><label>11</label><addr-line>Department of Clinical Genetics</addr-line>,</aff><aff id="af12"><label>12</label><addr-line>Department of Oncology</addr-line>,<institution>University of Helsinki and Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</aff><aff id="af13"><label>13</label><addr-line>Copenhagen General Population Study</addr-line>,</aff><aff id="af14"><label>14</label><addr-line>Department of Clinical Biochemistry</addr-line>,<institution>Herlev Hospital, Copenhagen University Hospital, University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</aff><aff id="af15"><label>15</label><addr-line>Ontario Cancer Genetics Network</addr-line>,</aff><aff id="af16"><label>16</label><addr-line>Prosserman Centre for Health Research</addr-line>,</aff><aff id="af17"><label>17</label><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country>,</aff><aff id="af18"><label>18</label><addr-line>Department of Molecular Genetics</addr-line>,</aff><aff id="af19"><label>19</label><addr-line>Department of Laboratory Medicine and Pathobiology</addr-line>,</aff><aff id="af20"><label>20</label><addr-line>Division of Epidemiology, Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country>,</aff><aff id="af21"><label>21</label><addr-line>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology</addr-line>,</aff><aff id="af22"><label>22</label><addr-line>Academic Unit of Pathology, Department of Neuroscience</addr-line>,<institution>University of Sheffield</institution>,<addr-line>Sheffield</addr-line>,<country>UK</country>,</aff><aff id="af23"><label>23</label><addr-line>Australian Breast Cancer Tissue Bank</addr-line>,</aff><aff id="af24"><label>24</label><addr-line>Westmead Institute for Cancer Research, Sydney Medical School Westmead</addr-line>,<institution>University of Sydney at the Westmead Millennium Institute</institution>,<addr-line>Westmead</addr-line>,<country>Australia</country>,</aff><aff id="af25"><label>25</label><addr-line>Molecular Diagnostics Laboratory INRASTES</addr-line>,<institution>National Centre for Scientific Research ‘Demokritos’</institution>,<addr-line>Athens</addr-line>,<country>Greece</country>,</aff><aff id="af26"><label>26</label><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles</addr-line>,<country>USA</country>,</aff><aff id="af27"><label>27</label><addr-line>University Breast Center Franconia, Department of Gynecology and Obstetrics</addr-line>,</aff><aff id="af28"><label>28</label><addr-line>Institute of Human Genetics</addr-line>,</aff><aff id="af29"><label>29</label><addr-line>Institute of Pathology</addr-line>,<institution>University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN</institution>,<addr-line>Erlangen</addr-line>,<country>Germany</country>,</aff><aff id="af30"><label>30</label><addr-line>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology</addr-line>,<institution>University of California at Los Angeles</institution>,<addr-line>Los Angeles</addr-line>,<country>USA</country>,</aff><aff id="af31"><label>31</label><addr-line>School of Medicine, Institute of Clinical Medicine, Oncology, Cancer Center of Eastern Finland</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</aff><aff id="af32"><label>32</label><addr-line>Imaging Center, Department of Clinical Pathology</addr-line>,</aff><aff id="af33"><label>33</label><addr-line>Cancer Center</addr-line>,<institution>Kuopio University Hospital</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</aff><aff id="af34"><label>34</label><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu</addr-line>,<institution>University of Oulu, Oulu University Hospital/NordLab Oulu</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</aff><aff id="af35"><label>35</label><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line>,</aff><aff id="af36"><label>36</label><addr-line>Molecular Genetics of Breast Cancer</addr-line>,</aff><aff id="af37"><label>37</label><addr-line>Division of Molecular Genetic Epidemiology</addr-line>,</aff><aff id="af38"><label>38</label><addr-line>Division of Cancer Epidemiology</addr-line>,</aff><aff id="af39"><label>39</label><addr-line>Molecular Epidemiology Group</addr-line>,<institution>German Cancer Research Center (DKFZ)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</aff><aff id="af40"><label>40</label><institution>German Cancer Consortium (DKTK)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</aff><aff id="af41"><label>41</label><addr-line>Department of Genetics</addr-line>,<institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country>,</aff><aff id="af42"><label>42</label><institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country>,</aff><aff id="af43"><label>43</label><addr-line>Human Genetics Group, Human Cancer Genetics Program</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country>,</aff><aff id="af44"><label>44</label><addr-line>Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia</addr-line>,<country>Spain</country>,</aff><aff id="af45"><label>45</label><addr-line>Division of Genetics and Epidemiology</addr-line>,</aff><aff id="af46"><label>46</label><addr-line>Division of Breast Cancer Research</addr-line>,<institution>Institute of Cancer Research</institution>,<addr-line>Sutton</addr-line>,<country>UK</country>,</aff><aff id="af47"><label>47</label><addr-line>Department of Genetics, Institute for Cancer Research</addr-line>,<institution>Oslo University Hospital, Radiumhospitalet</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country>,</aff><aff id="af48"><label>48</label><addr-line>Faculty of Medicine (Faculty Division Ahus)</addr-line>,<institution>University of Oslo (UiO)</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country>,</aff><aff id="af49"><label>49</label><addr-line>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018</addr-line>,<institution>Environmental Epidemiology of Cancer</institution>,<addr-line>Villejuif</addr-line>,<country>France</country>,</aff><aff id="af50"><label>50</label><institution>University Paris-Sud, UMRS 1018</institution>,<addr-line>Villejuif</addr-line>,<country>France</country>,</aff><aff id="af51"><label>51</label><addr-line>Division of Gynaecology and Obstetrics</addr-line>,<institution>Technische Universität München</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</aff><aff id="af52"><label>52</label><addr-line>Department of Breast Surgery, Herlev Hospital</addr-line>,<institution>Copenhagen University Hospital</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</aff><aff id="af53"><label>53</label><addr-line>Laboratory Medicine Program</addr-line>,<institution>University Health Network</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country>,</aff><aff id="af54"><label>54</label><addr-line>Human Genetics Division</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</aff><aff id="af55"><label>55</label><addr-line>Division of Genetics</addr-line>,<institution>Hunter Area Pathology Service and University of Newcastle</institution>,<addr-line>Newcastle</addr-line>,<country>Australia</country>,</aff><aff id="af56"><label>56</label><addr-line>Department of Medical Oncology, “Papageorgiou” Hospital</addr-line>,<institution>Aristotle University of Thessaloniki School of Medicine</institution>,<addr-line>Thessaloniki</addr-line>,<country>Greece</country>,</aff><aff id="af57"><label>57</label><addr-line>Epidemiology Program, Cancer Research Center</addr-line>,<institution>University of Hawaii</institution>,<addr-line>Honolulu</addr-line>,<country>USA</country>,</aff><aff id="af58"><label>58</label><addr-line>Department of Oncology</addr-line>,</aff><aff id="af59"><label>59</label><addr-line>Department of Pathology</addr-line>,<institution>Oulu University Hospital, University of Oulu</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</aff><aff id="af60"><label>60</label><institution>Saarland Cancer Registry</institution>,<addr-line>Saarbrücken</addr-line>,<country>Germany</country>,</aff><aff id="af61"><label>61</label><institution>Peter MacCallum Cancer Center</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</aff><aff id="af62"><label>62</label><institution>Westmead Millenium Institute for Medical Research</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country>,</aff><aff id="af63"><label>63</label><addr-line>Servicio de Cirugía General y Especialidades</addr-line>,<institution>Hospital Monte Naranco</institution>,<addr-line>Oviedo</addr-line>,<country>Spain</country>,</aff><aff id="af64"><label>64</label><addr-line>Servicio de Anatomía Patológica</addr-line>,</aff><aff id="af65"><label>65</label><addr-line>Servicio de Oncología Médica</addr-line>,<institution>Hospital Universitario La Paz</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country>,</aff><aff id="af66"><label>66</label><addr-line>Breakthrough Breast Cancer Research Centre and Division of Breast Cancer Research</addr-line>,</aff><aff id="af67"><label>67</label><addr-line>Breakthrough Breast Cancer Research Centre</addr-line>,<institution>The Institute of Cancer Research</institution>,<addr-line>London</addr-line>,<country>UK</country>,</aff><aff id="af68"><label>68</label><addr-line>Center Georges-Francois Leclerc</addr-line>,<institution>Registry of Gynecologic Tumors</institution>,<addr-line>Dijon</addr-line>,<country>France</country>,</aff><aff id="af69"><label>69</label><institution>Centre Eugène Marquis, Department of Medical Oncology</institution>,<addr-line>Rennes</addr-line>,<country>France</country>,</aff><aff id="af70"><label>70</label><institution>German Red Cross Blood Service of Baden-Württemberg-Hessen</institution>,<addr-line>Mannheim</addr-line>,<country>Germany</country>,</aff><aff id="af71"><label>71</label><addr-line>Medical Faculty Mannheim, Institute of Transfusion Medicine and Immunology</addr-line>,<institution>Heidelberg University</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</aff><aff id="af72"><label>72</label><addr-line>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center</addr-line>,<institution>The Ohio State University</institution>,<addr-line>Columbus</addr-line>,<country>USA</country>,</aff><aff id="af73"><label>73</label><institution>Roswell Park Cancer Institute</institution>,<addr-line>Buffalo</addr-line>,<country>USA</country>,</aff><aff id="af74"><label>74</label><addr-line>Department of Environmental & Occupational Health and of Social & Preventive Medicine</addr-line>,<institution>School of Public Health, Université de Montréal</institution>,<addr-line>Montreal</addr-line>,<country>Canada</country>,</aff><aff id="af75"><label>75</label><addr-line>Department of Medicine</addr-line>,<institution>McGill University</institution>,<addr-line>Montreal</addr-line>,<country>Canada</country>,</aff><aff id="af76"><label>76</label><addr-line>Division of Clinical Epidemiology</addr-line>,<institution>McGill University Health Centre, Royal Victoria Hospital</institution>,<addr-line>Montreal</addr-line>,<country>Canada</country>,</aff><aff id="af77"><label>77</label><addr-line>Cancer Genomics Laboratory</addr-line>,<institution>Centre Hospitalier Universitaire de Québec Research Center and Laval University</institution>,<addr-line>Quebec City</addr-line>,<country>Canada</country>,</aff><aff id="af78"><label>78</label><addr-line>Department of Epidemiology</addr-line>,<institution>University of California Irvine</institution>,<addr-line>Irvine</addr-line>,<country>USA</country>,</aff><aff id="af79"><label>79</label><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health</addr-line>,</aff><aff id="af80"><label>80</label><addr-line>Department of Pathology</addr-line>,</aff><aff id="af81"><label>81</label><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</aff><aff id="af82"><label>82</label><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center</addr-line>,<institution>Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>,<addr-line>Nashville</addr-line>,<country>USA</country>,</aff><aff id="af83"><label>83</label><institution>Cogentech Cancer Genetic Test Laboratory</institution>,<addr-line>Milan</addr-line>,<country>Italy</country>,</aff><aff id="af84"><label>84</label><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>,<addr-line>Milan</addr-line>,<country>Italy</country>,</aff><aff id="af85"><label>85</label><addr-line>Division of Cancer Prevention and Genetics</addr-line>,<institution>Istituto Europeo di Oncologia (IEO)</institution>,<addr-line>Milan</addr-line>,<country>Italy</country>,</aff><aff id="af86"><label>86</label><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country>,</aff><aff id="af87"><label>87</label><addr-line>Department of Surgical Oncology</addr-line>,</aff><aff id="af88"><label>88</label><addr-line>Department of Human Genetics & Department of Pathology</addr-line>,<institution>Leiden University Medical Center</institution>,<addr-line>Leiden</addr-line>,<country>The Netherlands</country>,</aff><aff id="af89"><label>89</label><addr-line>Family Cancer Clinic, Department of Medical Oncology</addr-line>,<institution>Erasmus MC-Daniel den Hoed Cancer Centrer</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</aff><aff id="af90"><label>90</label><institution>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA)</institution>,<addr-line>Bochum</addr-line>,<country>Germany</country>,</aff><aff id="af91"><label>91</label><addr-line>Department of Internal Medicine</addr-line>,<institution>Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus</institution>,<addr-line>Bonn</addr-line>,<country>Germany</country>,</aff><aff id="af92"><label>92</label><institution>Institute of Pathology, Medical Faculty of the University of Bonn</institution>,<addr-line>Bonn</addr-line>,<country>Germany</country>,</aff><aff id="af93"><label>93</label><addr-line>Institute for Occupational Medicine and Maritime Medicine</addr-line>,<institution>University Medical Center Hamburg</institution>,<addr-line>Eppendorf</addr-line>,<country>Germany</country>,</aff><aff id="af94"><label>94</label><institution>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology</institution>,<addr-line>Stuttgart</addr-line>,<country>Germany</country>,</aff><aff id="af95"><label>95</label><institution>University of Tübingen</institution>,<addr-line>Tübingen</addr-line>,<country>Germany</country>,</aff><aff id="af96"><label>96</label><addr-line>Department of Pathology</addr-line>,<institution>Erasmus University Medical Center</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</aff><aff id="af97"><label>97</label><addr-line>Department of Medical Oncology</addr-line>,<institution>Erasmus MC Cancer Institute</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</aff><aff id="af98"><label>98</label><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville</addr-line>,<country>USA</country>,</aff><aff id="af99"><label>99</label><addr-line>Department of Cancer Epidemiology and Prevention</addr-line>,<institution>M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country>,</aff><aff id="af100"><label>100</label><addr-line>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</aff><aff id="af101"><label>101</label><addr-line>Clinical Science Institute</addr-line>,<institution>University Hospital Galway</institution>,<addr-line>Galway</addr-line>,<country>Ireland</country>,</aff><aff id="af102"><label>102</label><addr-line>Department of Obstetrics and Gynecology</addr-line>,</aff><aff id="af103"><label>103</label><addr-line>National Center for Tumor Diseases</addr-line>,<institution>University of Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</aff><aff id="af104"><label>104</label><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</aff><aff id="af105"><label>105</label><addr-line>Anatomical Pathology</addr-line>,<institution>The Alfred Hospital</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</aff><aff id="af106"><label>106</label><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>The Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</aff><aff id="af107"><label>107</label><addr-line>Non-communicable Disease Epidemiology Department</addr-line>,<institution>London School of Hygiene and Tropical Medicine</institution>,<addr-line>London</addr-line>,<country>UK</country>,</aff><aff id="af108"><label>108</label><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</aff><aff id="af109"><label>109</label><addr-line>Center for Primary Health Care Research</addr-line>,<institution>University of Lund</institution>,<addr-line>Malmö</addr-line>,<country>Sweden</country>,</aff><aff id="af110"><label>110</label><addr-line>Institute of Human Genetics</addr-line>,<institution>Pontificia University Javeriana</institution>,<addr-line>Bogota</addr-line>,<country>Colombia</country>,</aff><aff id="af111"><label>111</label><addr-line>Institute of Pathology</addr-line>,<institution>Städtisches Klinikum Karlsruhe</institution>,<addr-line>Karlsruhe</addr-line>,<country>Germany</country>,</aff><aff id="af112"><label>112</label><addr-line>Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology</addr-line>,<institution>University Clinic Hamburg-Eppendorf</institution>,<addr-line>Hamburg</addr-line>,<country>Germany</country>,</aff><aff id="af113"><label>113</label><institution>Universital Hospital Gasthuisberg</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</aff><aff id="af114"><label>114</label><addr-line>Laboratory for Translational Genetics, Department of Oncology</addr-line>,<institution>University of Leuven</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</aff><aff id="af115"><label>115</label><institution>Vesalius Research Center (VRC), VIB</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</aff><aff id="af116"><label>116</label><institution>Beckman Research Institute of City of Hope</institution>,<addr-line>Duarte</addr-line>,<country>USA</country>,</aff><aff id="af117"><label>117</label><addr-line>Department of Radiation Oncology</addr-line>,</aff><aff id="af118"><label>118</label><addr-line>Department of Obstetrics and Gynaecology</addr-line>,<institution>Hannover Medical School</institution>,<addr-line>Hannover</addr-line>,<country>Germany</country>,</aff><aff id="af119"><label>119</label><addr-line>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine</addr-line>,<institution>Fondazione IRCCS Istituto Nazionale dei Tumori (INT)</institution>,<addr-line>Milan</addr-line>,<country>Italy</country> and</aff><aff id="af120"><label>120</label><addr-line>Division of Cancer Studies</addr-line>,<institution>Kings College London, Guy’s Hospital</institution>,<addr-line>London</addr-line>,<country>UK</country></aff></contrib-group><author-notes><corresp id="cor1"><label>*</label>To whom correspondence should be addressed at: Fergus J. Couch, Stabile 2-42, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Tel: +1 5072843623; Fax: +1 5075381937; Email: <email>couch.fergus@mayo.edu</email></corresp></author-notes><pub-date pub-type="ppub"><day>15</day><month>11</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>13</day><month>6</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>11</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>23</volume><issue>22</issue><fpage>6034</fpage><lpage>6046</lpage><history><date date-type="received"><day>19</day><month>11</month><year>2013</year></date><date date-type="rev-recd"><day>20</day><month>5</month><year>2014</year></date><date date-type="accepted"><day>10</day><month>6</month><year>2014</year></date></history><permissions><copyright-statement>Published by Oxford University Press 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.</copyright-statement><copyright-year>2014</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="ddu300.pdf"></self-uri><abstract><p>Mitotic index is an important component of histologic grade and has an etiologic role in breast tumorigenesis. Several small candidate gene studies have reported associations between variation in mitotic genes and breast cancer risk. We measured associations between 2156 single nucleotide polymorphisms (SNPs) from 194 mitotic genes and breast cancer risk, overall and by histologic grade, in the Breast Cancer Association Consortium (BCAC) iCOGS study (<italic>n</italic> = 39 067 cases; <italic>n</italic> = 42 106 controls). SNPs in <italic>TACC2</italic> [rs17550038: odds ratio (OR) = 1.24, 95% confidence interval (CI) 1.16–1.33, <italic>P</italic> = 4.2 × 10<sup>−10</sup>) and <italic>EIF3H</italic> (rs799890: OR = 1.07, 95% CI 1.04–1.11, <italic>P</italic> = 8.7 × 10<sup>−6</sup>) were significantly associated with risk of low-grade breast cancer. The <italic>TACC2</italic> signal was retained (rs17550038: OR = 1.15, 95% CI 1.07–1.23, <italic>P</italic> = 7.9 × 10<sup>−5</sup>) after adjustment for breast cancer risk SNPs in the nearby <italic>FGFR2</italic> gene, suggesting that <italic>TACC2</italic> is a novel, independent genome-wide significant genetic risk locus for low-grade breast cancer. While no SNPs were individually associated with high-grade disease, a pathway-level gene set analysis showed that variation across the 194 mitotic genes was associated with high-grade breast cancer risk (<italic>P</italic> = 2.1 × 10<sup>−3</sup>). These observations will provide insight into the contribution of mitotic defects to histological grade and the etiology of breast cancer.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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