Case Definitions, Diagnostic Algorithms, and Priorities in Encephalitis: Consensus Statement of the International Encephalitis Consortium
Identifieur interne : 001691 ( Pmc/Curation ); précédent : 001690; suivant : 001692Case Definitions, Diagnostic Algorithms, and Priorities in Encephalitis: Consensus Statement of the International Encephalitis Consortium
Auteurs : A. Venkatesan [États-Unis] ; A. R. Tunkel [États-Unis] ; K. C. Bloch ; A. S. Lauring ; J. Sejvar [Géorgie (pays)] ; A. Bitnun [Canada] ; J-P. Stahl [France] ; A. Mailles [France] ; M. Drebot ; C. E. Rupprecht [États-Unis] ; J. Yoder [Géorgie (pays)] ; J. R. Cope [Géorgie (pays)] ; M. R. Wilson ; R. J. Whitley ; J. Sullivan [Australie] ; J. Granerod ; C. Jones ; K. Eastwood [Australie] ; K. N. Ward ; D. N. Durrheim [Australie] ; M. V. Solbrig [Canada] ; L. Guo-Dong ; C. A. GlaserSource :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America [ 1058-4838 ] ; 2013.
Abstract
We present a consensus document that proposes a standardized case definition and diagnostic guidelines for evaluation of adults and children with suspected encephalitis. In addition, areas of research priority, including host genetics and selected emerging infections, are discussed.
Url:
DOI: 10.1093/cid/cit458
PubMed: 23861361
PubMed Central: 3783060
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M. Drebot<affiliation><nlm:aff id="af10"><addr-line>National Microbiology Laboratory</addr-line>
,<institution>Public Health Agency of Canada</institution>
,<addr-line>Winnipeg, Manitoba</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">Manitoba</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af17"><addr-line>Department of Medicine, and</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">and</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af18"><addr-line>Department of Neurosurgery</addr-line>
,<institution>University of Alabama at Birmingham</institution>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af21"><addr-line>Sydney Emerging Infectious Diseases and Biosecurity Institute, and</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">and</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af22"><addr-line>The Children's Hospital Westmead Clinical School</addr-line>
,<institution>University of Sydney</institution>
,<addr-line>New South Wales</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af24"><addr-line>Division of Infection and Immunity</addr-line>
,<institution>University College London</institution>
,<country>England</country>
</nlm:aff>
<wicri:noCountry code="nlm country">England</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af28"><addr-line>Department of Viral Encephalitis and Arbovirus, State Key Laboratory for Infectious Disease Prevention and Control</addr-line>
,<institution>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention</institution>
,<addr-line>Beijing</addr-line>
,<country>People's Republic of China;</country>
</nlm:aff>
<wicri:noCountry code="nlm country">People's Republic of China;</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af29"><addr-line>Division of Communicable Disease Control, California Department of Public Health, Richmond</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">Richmond</wicri:noCountry>
</affiliation>
Le document en format XML
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</affiliation>
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,<addr-line>Massachusetts</addr-line>
</nlm:aff>
</affiliation>
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<wicri:noCountry code="subfield">and</wicri:noCountry>
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<author><name sortKey="Sullivan, J" sort="Sullivan, J" uniqKey="Sullivan J" first="J." last="Sullivan">J. Sullivan</name>
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<author><name sortKey="Granerod, J" sort="Granerod, J" uniqKey="Granerod J" first="J." last="Granerod">J. Granerod</name>
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<author><name sortKey="Jones, C" sort="Jones, C" uniqKey="Jones C" first="C." last="Jones">C. Jones</name>
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<affiliation><nlm:aff id="af22"><addr-line>The Children's Hospital Westmead Clinical School</addr-line>
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<author><name sortKey="Eastwood, K" sort="Eastwood, K" uniqKey="Eastwood K" first="K." last="Eastwood">K. Eastwood</name>
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<author><name sortKey="Ward, K N" sort="Ward, K N" uniqKey="Ward K" first="K. N." last="Ward">K. N. Ward</name>
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<wicri:noCountry code="nlm country">England</wicri:noCountry>
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<author><name sortKey="Solbrig, M V" sort="Solbrig, M V" uniqKey="Solbrig M" first="M. V." last="Solbrig">M. V. Solbrig</name>
<affiliation wicri:level="1"><nlm:aff id="af27"><addr-line>Department of Medicine (Neurology) and Medical Microbiology</addr-line>
,<institution>University of Manitoba</institution>
,<addr-line>Winnipeg</addr-line>
,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Guo Dong, L" sort="Guo Dong, L" uniqKey="Guo Dong L" first="L." last="Guo-Dong">L. Guo-Dong</name>
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,<institution>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention</institution>
,<addr-line>Beijing</addr-line>
,<country>People's Republic of China;</country>
</nlm:aff>
<wicri:noCountry code="nlm country">People's Republic of China;</wicri:noCountry>
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<author><name sortKey="Glaser, C A" sort="Glaser, C A" uniqKey="Glaser C" first="C. A." last="Glaser">C. A. Glaser</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Case Definitions, Diagnostic Algorithms, and Priorities in Encephalitis: Consensus Statement of the International Encephalitis Consortium</title>
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<country xml:lang="fr">États-Unis</country>
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,<addr-line>Providence, Rhode Island</addr-line>
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<affiliation><nlm:aff id="af3"><addr-line>Department of Medicine (Infectious Diseases) and</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af4"><addr-line>Department of Preventive Medicine</addr-line>
,<institution>Vanderbilt University School of Medicine</institution>
, Nashville,<addr-line>Tennessee</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lauring, A S" sort="Lauring, A S" uniqKey="Lauring A" first="A. S." last="Lauring">A. S. Lauring</name>
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,<addr-line>Ontario</addr-line>
,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Stahl, J P" sort="Stahl, J P" uniqKey="Stahl J" first="J-P." last="Stahl">J-P. Stahl</name>
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,<institution>CHU and University 1</institution>
,<addr-line>Grenoble</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
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<author><name sortKey="Mailles, A" sort="Mailles, A" uniqKey="Mailles A" first="A." last="Mailles">A. Mailles</name>
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,<institution>French Institute for Public Health Surveillance</institution>
,<addr-line>Saint-Maurice</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Drebot, M" sort="Drebot, M" uniqKey="Drebot M" first="M." last="Drebot">M. Drebot</name>
<affiliation><nlm:aff id="af10"><addr-line>National Microbiology Laboratory</addr-line>
,<institution>Public Health Agency of Canada</institution>
,<addr-line>Winnipeg, Manitoba</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">Manitoba</wicri:noCountry>
</affiliation>
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<author><name sortKey="Rupprecht, C E" sort="Rupprecht, C E" uniqKey="Rupprecht C" first="C. E." last="Rupprecht">C. E. Rupprecht</name>
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,<addr-line>Manhattan, Kansas</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kansas</region>
</placeName>
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</affiliation>
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<author><name sortKey="Yoder, J" sort="Yoder, J" uniqKey="Yoder J" first="J." last="Yoder">J. Yoder</name>
<affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Waterborne Disease Prevention Branch</addr-line>
,<institution>National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention</institution>
,<addr-line>Atlanta, Georgia</addr-line>
</nlm:aff>
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<author><name sortKey="Cope, J R" sort="Cope, J R" uniqKey="Cope J" first="J. R." last="Cope">J. R. Cope</name>
<affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Waterborne Disease Prevention Branch</addr-line>
,<institution>National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention</institution>
,<addr-line>Atlanta, Georgia</addr-line>
</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wilson, M R" sort="Wilson, M R" uniqKey="Wilson M" first="M. R." last="Wilson">M. R. Wilson</name>
<affiliation><nlm:aff id="af13"><addr-line>Department of Neurology and</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af14"><addr-line>Department of Medicine</addr-line>
,<institution>Boston University School of Medicine</institution>
,<addr-line>Massachusetts</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Whitley, R J" sort="Whitley, R J" uniqKey="Whitley R" first="R. J." last="Whitley">R. J. Whitley</name>
<affiliation><nlm:aff id="af15"><addr-line>Department of Pediatrics</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af16"><addr-line>Department of Microbiology</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af17"><addr-line>Department of Medicine, and</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">and</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af18"><addr-line>Department of Neurosurgery</addr-line>
,<institution>University of Alabama at Birmingham</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sullivan, J" sort="Sullivan, J" uniqKey="Sullivan J" first="J." last="Sullivan">J. Sullivan</name>
<affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Central Clinical School</addr-line>
,<institution>University of Sydney</institution>
,<addr-line>New South Wales</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Granerod, J" sort="Granerod, J" uniqKey="Granerod J" first="J." last="Granerod">J. Granerod</name>
<affiliation><nlm:aff id="af20"><addr-line>Virus Reference Department</addr-line>
,<institution>Public Health England</institution>
,<addr-line>London</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jones, C" sort="Jones, C" uniqKey="Jones C" first="C." last="Jones">C. Jones</name>
<affiliation><nlm:aff id="af21"><addr-line>Sydney Emerging Infectious Diseases and Biosecurity Institute, and</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">and</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af22"><addr-line>The Children's Hospital Westmead Clinical School</addr-line>
,<institution>University of Sydney</institution>
,<addr-line>New South Wales</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Eastwood, K" sort="Eastwood, K" uniqKey="Eastwood K" first="K." last="Eastwood">K. Eastwood</name>
<affiliation wicri:level="1"><nlm:aff id="af23"><institution>Hunter New England Population Health</institution>
,<addr-line>Wallsend, New South Wales</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ward, K N" sort="Ward, K N" uniqKey="Ward K" first="K. N." last="Ward">K. N. Ward</name>
<affiliation><nlm:aff id="af20"><addr-line>Virus Reference Department</addr-line>
,<institution>Public Health England</institution>
,<addr-line>London</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af24"><addr-line>Division of Infection and Immunity</addr-line>
,<institution>University College London</institution>
,<country>England</country>
</nlm:aff>
<wicri:noCountry code="nlm country">England</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Durrheim, D N" sort="Durrheim, D N" uniqKey="Durrheim D" first="D. N." last="Durrheim">D. N. Durrheim</name>
<affiliation><nlm:aff id="af25"><institution>University of Newcastle, and</institution>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af26"><institution>Hunter Medical Research Institute</institution>
,<addr-line>Wallsend, New South Wales</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Solbrig, M V" sort="Solbrig, M V" uniqKey="Solbrig M" first="M. V." last="Solbrig">M. V. Solbrig</name>
<affiliation wicri:level="1"><nlm:aff id="af27"><addr-line>Department of Medicine (Neurology) and Medical Microbiology</addr-line>
,<institution>University of Manitoba</institution>
,<addr-line>Winnipeg</addr-line>
,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guo Dong, L" sort="Guo Dong, L" uniqKey="Guo Dong L" first="L." last="Guo-Dong">L. Guo-Dong</name>
<affiliation><nlm:aff id="af28"><addr-line>Department of Viral Encephalitis and Arbovirus, State Key Laboratory for Infectious Disease Prevention and Control</addr-line>
,<institution>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention</institution>
,<addr-line>Beijing</addr-line>
,<country>People's Republic of China;</country>
</nlm:aff>
<wicri:noCountry code="nlm country">People's Republic of China;</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Glaser, C A" sort="Glaser, C A" uniqKey="Glaser C" first="C. A." last="Glaser">C. A. Glaser</name>
<affiliation><nlm:aff id="af29"><addr-line>Division of Communicable Disease Control, California Department of Public Health, Richmond</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">Richmond</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</title>
<idno type="ISSN">1058-4838</idno>
<idno type="eISSN">1537-6591</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>We present a consensus document that proposes a standardized case definition and diagnostic guidelines for evaluation of adults and children with suspected encephalitis. In addition, areas of research priority, including host genetics and selected emerging infections, are discussed.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Infect Dis</journal-id>
<journal-id journal-id-type="iso-abbrev">Clin. Infect. Dis</journal-id>
<journal-id journal-id-type="publisher-id">cid</journal-id>
<journal-id journal-id-type="hwp">cid</journal-id>
<journal-title-group><journal-title>Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</journal-title>
</journal-title-group>
<issn pub-type="ppub">1058-4838</issn>
<issn pub-type="epub">1537-6591</issn>
<publisher><publisher-name>Oxford University Press</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23861361</article-id>
<article-id pub-id-type="pmc">3783060</article-id>
<article-id pub-id-type="doi">10.1093/cid/cit458</article-id>
<article-id pub-id-type="publisher-id">cit458</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Articles and Commentaries</subject>
</subj-group>
</article-categories>
<title-group><article-title>Case Definitions, Diagnostic Algorithms, and Priorities in Encephalitis: Consensus Statement of the International Encephalitis Consortium</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Venkatesan</surname>
<given-names>A.</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tunkel</surname>
<given-names>A. R.</given-names>
</name>
<xref ref-type="aff" rid="af2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bloch</surname>
<given-names>K. C.</given-names>
</name>
<xref ref-type="aff" rid="af3">3</xref>
<xref ref-type="aff" rid="af4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lauring</surname>
<given-names>A. S.</given-names>
</name>
<xref ref-type="aff" rid="af5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sejvar</surname>
<given-names>J.</given-names>
</name>
<xref ref-type="aff" rid="af6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bitnun</surname>
<given-names>A.</given-names>
</name>
<xref ref-type="aff" rid="af7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stahl</surname>
<given-names>J-P.</given-names>
</name>
<xref ref-type="aff" rid="af8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mailles</surname>
<given-names>A.</given-names>
</name>
<xref ref-type="aff" rid="af9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Drebot</surname>
<given-names>M.</given-names>
</name>
<xref ref-type="aff" rid="af10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rupprecht</surname>
<given-names>C. E.</given-names>
</name>
<xref ref-type="aff" rid="af11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yoder</surname>
<given-names>J.</given-names>
</name>
<xref ref-type="aff" rid="af12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cope</surname>
<given-names>J. R.</given-names>
</name>
<xref ref-type="aff" rid="af12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wilson</surname>
<given-names>M. R.</given-names>
</name>
<xref ref-type="aff" rid="af13">13</xref>
<xref ref-type="aff" rid="af14">14</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Whitley</surname>
<given-names>R. J.</given-names>
</name>
<xref ref-type="aff" rid="af15">15</xref>
<xref ref-type="aff" rid="af16">16</xref>
<xref ref-type="aff" rid="af17">17</xref>
<xref ref-type="aff" rid="af18">18</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sullivan</surname>
<given-names>J.</given-names>
</name>
<xref ref-type="aff" rid="af19">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Granerod</surname>
<given-names>J.</given-names>
</name>
<xref ref-type="aff" rid="af20">20</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jones</surname>
<given-names>C.</given-names>
</name>
<xref ref-type="aff" rid="af21">21</xref>
<xref ref-type="aff" rid="af22">22</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Eastwood</surname>
<given-names>K.</given-names>
</name>
<xref ref-type="aff" rid="af23">23</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ward</surname>
<given-names>K. N.</given-names>
</name>
<xref ref-type="aff" rid="af20">20</xref>
<xref ref-type="aff" rid="af24">24</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Durrheim</surname>
<given-names>D. N.</given-names>
</name>
<xref ref-type="aff" rid="af25">25</xref>
<xref ref-type="aff" rid="af26">26</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Solbrig</surname>
<given-names>M. V.</given-names>
</name>
<xref ref-type="aff" rid="af27">27</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Guo-Dong</surname>
<given-names>L.</given-names>
</name>
<xref ref-type="aff" rid="af28">28</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Glaser</surname>
<given-names>C. A.</given-names>
</name>
<xref ref-type="aff" rid="af29">29</xref>
</contrib>
<on-behalf-of>on behalf of the International Encephalitis Consortium</on-behalf-of>
<aff id="af1"><label>1</label>
<addr-line>Johns Hopkins Encephalitis Center, Department of Neurology</addr-line>
,<institution>Johns Hopkins University School of Medicine</institution>
,<addr-line>Baltimore, Maryland</addr-line>
</aff>
<aff id="af2"><label>2</label>
<institution>Warren Alpert Medical School of Brown University</institution>
,<addr-line>Providence, Rhode Island</addr-line>
</aff>
<aff id="af3"><label>3</label>
<addr-line>Department of Medicine (Infectious Diseases) and</addr-line>
</aff>
<aff id="af4"><label>4</label>
<addr-line>Department of Preventive Medicine</addr-line>
,<institution>Vanderbilt University School of Medicine</institution>
, Nashville,<addr-line>Tennessee</addr-line>
</aff>
<aff id="af5"><label>5</label>
<addr-line>Division of Infectious Diseases, Department of Medicine</addr-line>
,<institution>University of Michigan Medical School</institution>
,<addr-line>Ann Arbor</addr-line>
</aff>
<aff id="af6"><label>6</label>
<addr-line>Division of High-Consequence Pathogens and Pathology</addr-line>
,<institution>National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention</institution>
,<addr-line>Atlanta, Georgia</addr-line>
</aff>
<aff id="af7"><label>7</label>
<addr-line>Division of Infectious Diseases, Department of Pediatrics</addr-line>
,<institution>The Hospital for Sick Children, University of Toronto</institution>
,<addr-line>Ontario</addr-line>
,<country>Canada</country>
</aff>
<aff id="af8"><label>8</label>
<addr-line>Infectious Diseases Department</addr-line>
,<institution>CHU and University 1</institution>
,<addr-line>Grenoble</addr-line>
,<country>France</country>
</aff>
<aff id="af9"><label>9</label>
<addr-line>Department Infectious Diseases</addr-line>
,<institution>French Institute for Public Health Surveillance</institution>
,<addr-line>Saint-Maurice</addr-line>
,<country>France</country>
</aff>
<aff id="af10"><label>10</label>
<addr-line>National Microbiology Laboratory</addr-line>
,<institution>Public Health Agency of Canada</institution>
,<addr-line>Winnipeg, Manitoba</addr-line>
</aff>
<aff id="af11"><label>11</label>
<institution>Global Alliance For Rabies Control</institution>
,<addr-line>Manhattan, Kansas</addr-line>
</aff>
<aff id="af12"><label>12</label>
<addr-line>Waterborne Disease Prevention Branch</addr-line>
,<institution>National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention</institution>
,<addr-line>Atlanta, Georgia</addr-line>
</aff>
<aff id="af13"><label>13</label>
<addr-line>Department of Neurology and</addr-line>
</aff>
<aff id="af14"><label>14</label>
<addr-line>Department of Medicine</addr-line>
,<institution>Boston University School of Medicine</institution>
,<addr-line>Massachusetts</addr-line>
</aff>
<aff id="af15"><label>15</label>
<addr-line>Department of Pediatrics</addr-line>
</aff>
<aff id="af16"><label>16</label>
<addr-line>Department of Microbiology</addr-line>
</aff>
<aff id="af17"><label>17</label>
<addr-line>Department of Medicine, and</addr-line>
</aff>
<aff id="af18"><label>18</label>
<addr-line>Department of Neurosurgery</addr-line>
,<institution>University of Alabama at Birmingham</institution>
</aff>
<aff id="af19"><label>19</label>
<addr-line>Central Clinical School</addr-line>
,<institution>University of Sydney</institution>
,<addr-line>New South Wales</addr-line>
,<country>Australia</country>
</aff>
<aff id="af20"><label>20</label>
<addr-line>Virus Reference Department</addr-line>
,<institution>Public Health England</institution>
,<addr-line>London</addr-line>
</aff>
<aff id="af21"><label>21</label>
<addr-line>Sydney Emerging Infectious Diseases and Biosecurity Institute, and</addr-line>
</aff>
<aff id="af22"><label>22</label>
<addr-line>The Children's Hospital Westmead Clinical School</addr-line>
,<institution>University of Sydney</institution>
,<addr-line>New South Wales</addr-line>
</aff>
<aff id="af23"><label>23</label>
<institution>Hunter New England Population Health</institution>
,<addr-line>Wallsend, New South Wales</addr-line>
,<country>Australia</country>
</aff>
<aff id="af24"><label>24</label>
<addr-line>Division of Infection and Immunity</addr-line>
,<institution>University College London</institution>
,<country>England</country>
</aff>
<aff id="af25"><label>25</label>
<institution>University of Newcastle, and</institution>
</aff>
<aff id="af26"><label>26</label>
<institution>Hunter Medical Research Institute</institution>
,<addr-line>Wallsend, New South Wales</addr-line>
,<country>Australia</country>
</aff>
<aff id="af27"><label>27</label>
<addr-line>Department of Medicine (Neurology) and Medical Microbiology</addr-line>
,<institution>University of Manitoba</institution>
,<addr-line>Winnipeg</addr-line>
,<country>Canada</country>
</aff>
<aff id="af28"><label>28</label>
<addr-line>Department of Viral Encephalitis and Arbovirus, State Key Laboratory for Infectious Disease Prevention and Control</addr-line>
,<institution>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention</institution>
,<addr-line>Beijing</addr-line>
,<country>People's Republic of China;</country>
</aff>
<aff id="af29"><label>29</label>
<addr-line>Division of Communicable Disease Control, California Department of Public Health, Richmond</addr-line>
</aff>
</contrib-group>
<contrib-group><contrib contrib-type="author"><name><surname>Sheriff</surname>
<given-names>Heather</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Brown</surname>
<given-names>David</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Farnon</surname>
<given-names>Eileen</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Messenger</surname>
<given-names>Sharon</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Paterson</surname>
<given-names>Beverley</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Soldatos</surname>
<given-names>Ariane</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Roy</surname>
<given-names>Sharon</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Visvesvara</surname>
<given-names>Govinda</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Beach</surname>
<given-names>Michael</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Nasci</surname>
<given-names>Roger</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Pertowski</surname>
<given-names>Carol</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Schmid</surname>
<given-names>Scott</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Rascoe</surname>
<given-names>Lisa</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Montgomery</surname>
<given-names>Joel</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Tong</surname>
<given-names>Suxiang</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Breiman</surname>
<given-names>Robert</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Franka</surname>
<given-names>Richard</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Keuhnert</surname>
<given-names>Matt</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Angulo</surname>
<given-names>Fred</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Cherry</surname>
<given-names>James</given-names>
</name>
</contrib>
</contrib-group>
<author-notes><corresp>Correspondence: Arun Venkatesan, MD, PhD, Johns Hopkins University School of Medicine, 600 N Wolfe St, Meyer 6-113, Baltimore, MD 21287 (<email>avenkat2@jhmi.edu</email>
).</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>15</day>
<month>10</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub"><day>15</day>
<month>7</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>15</day>
<month>10</month>
<year>2014</year>
</pub-date>
<pmc-comment> PMC Release delay is 12 months and
0 days and was based on the . </pmc-comment>
<volume>57</volume>
<issue>8</issue>
<fpage>1114</fpage>
<lpage>1128</lpage>
<history><date date-type="received"><day>10</day>
<month>5</month>
<year>2013</year>
</date>
<date date-type="accepted"><day>3</day>
<month>7</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-statement>© The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: <email>journals.permissions@oup.com</email>
.</copyright-statement>
<copyright-year>2013</copyright-year>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="cit458.pdf"></self-uri>
<abstract abstract-type="precis"><p>We present a consensus document that proposes a standardized case definition and diagnostic guidelines for evaluation of adults and children with suspected encephalitis. In addition, areas of research priority, including host genetics and selected emerging infections, are discussed.</p>
</abstract>
<abstract><p><bold><italic>Background.</italic>
</bold>
Encephalitis continues to result in substantial morbidity and mortality worldwide. Advances in diagnosis and management have been limited, in part, by a lack of consensus on case definitions, standardized diagnostic approaches, and priorities for research.</p>
<p><bold><italic>Methods.</italic>
</bold>
In March 2012, the International Encephalitis Consortium, a committee begun in 2010 with members worldwide, held a meeting in Atlanta to discuss recent advances in encephalitis and to set priorities for future study.</p>
<p><bold><italic>Results.</italic>
</bold>
We present a consensus document that proposes a standardized case definition and diagnostic guidelines for evaluation of adults and children with suspected encephalitis. In addition, areas of research priority, including host genetics and selected emerging infections, are discussed.</p>
<p><bold><italic>Conclusions.</italic>
</bold>
We anticipate that this document, representing a synthesis of our discussions and supported by literature, will serve as a practical aid to clinicians evaluating patients with suspected encephalitis and will identify key areas and approaches to advance our knowledge of encephalitis.</p>
</abstract>
<kwd-group><kwd>encephalitis</kwd>
<kwd>guidelines</kwd>
<kwd>viral</kwd>
<kwd>autoimmune</kwd>
<kwd>host genetics</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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