Towards an HIV cure: science and debate from the International AIDS Society 2013 symposium
Identifieur interne : 001522 ( Pmc/Curation ); précédent : 001521; suivant : 001523Towards an HIV cure: science and debate from the International AIDS Society 2013 symposium
Auteurs : Damian Fj Purcell [Australie] ; Julian H. Elliott [Australie] ; Anna-Laura Ross [France, Suisse] ; John Frater [Royaume-Uni]Source :
- Retrovirology [ 1742-4690 ] ; 2013.
Abstract
The International AIDS Society convened the multi-stakeholder “Towards an HIV Cure” symposium in Kuala Lumpur, Malaysia in 2013 to address the significant research challenges posed by the search for a cure for HIV infection. Current antiretroviral regimens select for a small reservoir of cells that harbour latent HIV provirus, produce few or no HIV virions, and resist detection or clearance by host immunity. The symposium examined basic molecular science and animal model data, and emerging and ongoing clinical trial results to prioritise strategies and determine the viral and immune responses that could lead to HIV remission without ART. Here we review the presentations that scrutinized the molecular mechanisms controlling virus expression from proviral DNA, and the intrinsic cellular restriction and immune mechanisms preventing viral production. Insights from the basic science have translated into new therapeutic strategies seeking HIV remission without ongoing therapy, and much interest was focused on these ongoing trials. We also summarise the emerging ethical issues and patient expectations as concepts move into the clinic.
Url:
DOI: 10.1186/1742-4690-10-134
PubMed: 24224983
PubMed Central: 3828479
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Elliott</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Infectious Diseases, Alfred Hospital and Monash University, Prahran, VIC 3181, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Infectious Diseases, Alfred Hospital and Monash University, Prahran, VIC 3181</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I3">Burnet Institute, Prahran, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute, Prahran</wicri:regionArea></affiliation></author><author><name sortKey="Ross, Anna Laura" sort="Ross, Anna Laura" uniqKey="Ross A" first="Anna-Laura" last="Ross">Anna-Laura Ross</name><affiliation wicri:level="1"><nlm:aff id="I4">French National Agency for Research on AIDS and viral hepatitis, ANRS, 101 rue de Tolbiac, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>French National Agency for Research on AIDS and viral hepatitis, ANRS, 101 rue de Tolbiac, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I5">International AIDS Society, Geneva, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>International AIDS Society, Geneva</wicri:regionArea></affiliation></author><author><name sortKey="Frater, John" sort="Frater, John" uniqKey="Frater J" first="John" last="Frater">John Frater</name><affiliation wicri:level="1"><nlm:aff id="I6">Peter Medawar Building for Pathogen Research, Oxford University, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Peter Medawar Building for Pathogen Research, Oxford University, Oxford</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I7">Oxford NIHR Biomedical Research Centre, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford NIHR Biomedical Research Centre, Oxford</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I8">Oxford Martin School, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Martin School, Oxford</wicri:regionArea></affiliation></author></analytic><series><title level="j">Retrovirology</title><idno type="eISSN">1742-4690</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The International AIDS Society convened the multi-stakeholder “Towards an HIV Cure” symposium in Kuala Lumpur, Malaysia in 2013 to address the significant research challenges posed by the search for a cure for HIV infection. Current antiretroviral regimens select for a small reservoir of cells that harbour latent HIV provirus, produce few or no HIV virions, and resist detection or clearance by host immunity. The symposium examined basic molecular science and animal model data, and emerging and ongoing clinical trial results to prioritise strategies and determine the viral and immune responses that could lead to HIV remission without ART. Here we review the presentations that scrutinized the molecular mechanisms controlling virus expression from proviral DNA, and the intrinsic cellular restriction and immune mechanisms preventing viral production. Insights from the basic science have translated into new therapeutic strategies seeking HIV remission without ongoing therapy, and much interest was focused on these ongoing trials. We also summarise the emerging ethical issues and patient expectations as concepts move into the clinic.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Deeks, Sg" uniqKey="Deeks S">SG Deeks</name></author><author><name sortKey="Autran, B" uniqKey="Autran B">B Autran</name></author><author><name sortKey="Berkhout, B" uniqKey="Berkhout B">B Berkhout</name></author><author><name sortKey="Benkirane, M" uniqKey="Benkirane M">M Benkirane</name></author><author><name sortKey="Cairns, S" uniqKey="Cairns S">S Cairns</name></author><author><name sortKey="Chomont, N" uniqKey="Chomont N">N Chomont</name></author><author><name sortKey="Chun, Tw" uniqKey="Chun T">TW Chun</name></author><author><name sortKey="Churchill, M" uniqKey="Churchill M">M Churchill</name></author><author><name sortKey="Di Mascio, M" uniqKey="Di Mascio M">M Di Mascio</name></author><author><name sortKey="Katlama, C" uniqKey="Katlama C">C 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Retrovirology</journal-id><journal-id journal-id-type="iso-abbrev">Retrovirology</journal-id><journal-title-group><journal-title>Retrovirology</journal-title></journal-title-group><issn pub-type="epub">1742-4690</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24224983</article-id><article-id pub-id-type="pmc">3828479</article-id><article-id pub-id-type="publisher-id">1742-4690-10-134</article-id><article-id pub-id-type="doi">10.1186/1742-4690-10-134</article-id><article-categories><subj-group subj-group-type="heading"><subject>Commentary</subject></subj-group></article-categories><title-group><article-title>Towards an HIV cure: science and debate from the International AIDS Society 2013 symposium</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes" id="A1"><name><surname>Purcell</surname><given-names>Damian FJ</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>dfjp@unimelb.edu.au</email></contrib><contrib contrib-type="author" equal-contrib="yes" id="A2"><name><surname>Elliott</surname><given-names>Julian H</given-names></name><xref ref-type="aff" rid="I2">2</xref><xref ref-type="aff" rid="I3">3</xref><email>julian.elliott@monash.edu</email></contrib><contrib contrib-type="author" equal-contrib="yes" id="A3"><name><surname>Ross</surname><given-names>Anna-Laura</given-names></name><xref ref-type="aff" rid="I4">4</xref><xref ref-type="aff" rid="I5">5</xref><email>anna-laura.ross@anrs.fr</email></contrib><contrib contrib-type="author" equal-contrib="yes" id="A4"><name><surname>Frater</surname><given-names>John</given-names></name><xref ref-type="aff" rid="I6">6</xref><xref ref-type="aff" rid="I7">7</xref><xref ref-type="aff" rid="I8">8</xref><email>john.frater@ndm.ox.ac.uk</email></contrib></contrib-group><aff id="I1"><label>1</label>Department of Microbiology and Immunology, The University of Melbourne, Parkville, VIC 3010, Australia</aff><aff id="I2"><label>2</label>Department of Infectious Diseases, Alfred Hospital and Monash University, Prahran, VIC 3181, Australia</aff><aff id="I3"><label>3</label>Burnet Institute, Prahran, Australia</aff><aff id="I4"><label>4</label>French National Agency for Research on AIDS and viral hepatitis, ANRS, 101 rue de Tolbiac, Paris, France</aff><aff id="I5"><label>5</label>International AIDS Society, Geneva, Switzerland</aff><aff id="I6"><label>6</label>Peter Medawar Building for Pathogen Research, Oxford University, Oxford, UK</aff><aff id="I7"><label>7</label>Oxford NIHR Biomedical Research Centre, Oxford, UK</aff><aff id="I8"><label>8</label>Oxford Martin School, Oxford, UK</aff><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>13</day><month>11</month><year>2013</year></pub-date><volume>10</volume><fpage>134</fpage><lpage>134</lpage><history><date date-type="received"><day>23</day><month>8</month><year>2013</year></date><date date-type="accepted"><day>4</day><month>11</month><year>2013</year></date></history><permissions><copyright-statement>Copyright © 2013 Purcell et al.; licensee BioMed Central Ltd.</copyright-statement><copyright-year>2013</copyright-year><copyright-holder>Purcell et al.; licensee BioMed Central Ltd.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri xlink:href="http://www.retrovirology.com/content/10/1/134"></self-uri><abstract><p>The International AIDS Society convened the multi-stakeholder “Towards an HIV Cure” symposium in Kuala Lumpur, Malaysia in 2013 to address the significant research challenges posed by the search for a cure for HIV infection. Current antiretroviral regimens select for a small reservoir of cells that harbour latent HIV provirus, produce few or no HIV virions, and resist detection or clearance by host immunity. The symposium examined basic molecular science and animal model data, and emerging and ongoing clinical trial results to prioritise strategies and determine the viral and immune responses that could lead to HIV remission without ART. Here we review the presentations that scrutinized the molecular mechanisms controlling virus expression from proviral DNA, and the intrinsic cellular restriction and immune mechanisms preventing viral production. Insights from the basic science have translated into new therapeutic strategies seeking HIV remission without ongoing therapy, and much interest was focused on these ongoing trials. We also summarise the emerging ethical issues and patient expectations as concepts move into the clinic.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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