Right ventricle free wall mechanics in metabolic syndrome without type-2 diabetes: effects of a 3-month lifestyle intervention program
Identifieur interne : 001490 ( Pmc/Curation ); précédent : 001489; suivant : 001491Right ventricle free wall mechanics in metabolic syndrome without type-2 diabetes: effects of a 3-month lifestyle intervention program
Auteurs : Juan Serrano-Ferrer [France] ; Guillaume Walther [France, Australie] ; Edward Crendal [France, Australie] ; Agnès Vinet [France] ; Frédéric Dutheil [Australie, France] ; Geraldine Naughton [Australie] ; Bruno Lesourd [France] ; Robert Chapier [France] ; Daniel Courteix [Australie, France] ; Philippe Obert [France, Australie]Source :
- Cardiovascular Diabetology [ 1475-2840 ] ; 2014.
Abstract
Growing evidence demonstrates subtle left ventricular myocardial dysfunction in patients with metabolic syndrome (MetS), with central obesity, glucose intolerance and inflammation emerging as important contributors. Whether these results can be translated to the right ventricle (RV) is not yet fully elucidated. Furthermore, although lifestyle intervention favorably impacts MetS components and inflammatory biomarkers, its effect on RV myocardial function remains unknown today.
Thirty-nine MetS adults free of diabetes were enrolled in a three month lifestyle intervention program including diet and physical exercise, and compared with forty healthy controls. Blood biochemistry, echocardiography including tissue Doppler imaging (TDI), and vector velocity imaging of the RV free wall to assess global longitudinal strain (GLS) and strain rates (SR) were obtained at baseline and after the intervention.
Compared with controls, MetS patients presented similar right atrial and RV morphology but reduced systolic (P = 0.04) and early diastolic (P = 0.02) velocities of the tricuspid annulus. They showed attenuated RV GLS (−21.4 ± 4.5vs-25.7 ± 4.9%, P < 0.001) as well as early diastolic (P = 0.003) and systolic (P < 0.001) SR. Multiple regression analyses revealed log PAI-1 active, (P < 0.001), log adiponectin, (P = 0.01), LV mass indexed (P = 0.004) and central fat (P = 0.03) as independent predictors of RV GLS (R2 = 0.46, P < 0.001). Biological markers of MetS and inflammation as well as RV GLS (−21.8 ± 3.8vs-24.3 ± 3.0%, P = 0.009) and systolic (P = 0.003) and early diastolic (P = 0.01) SR, but not TDI indexes, significantly improved after diet and exercise training, and vector velocity imaging data in MetS following the lifestyle intervention no longer differed from controls.
MetS is associated with subtle impairments in both RV free wall diastolic and systolic myocardial function which could be partly related to central-obesity induced changes in pro- and anti-inflammatory cytokines and left ventricular remodeling. The favorable impact of healthy dieting and physical activity on RV free wall mechanics indicates that cellular and sub-cellular alterations responsible for the RV myocardial abnormalities are probably not permanent and modifiable throughout adequate interventional strategies.
American National Institutes of Health database
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DOI: 10.1186/s12933-014-0116-9
PubMed: 25407698
PubMed Central: 4149206
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Pharm-Ecologie cardiovasculaire, LAPEC EA4278, Avignon</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Australian Catholic University, School of Exercise Science, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Catholic University, School of Exercise Science, Melbourne</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25407698</idno><idno type="pmc">4149206</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149206</idno><idno type="RBID">PMC:4149206</idno><idno type="doi">10.1186/s12933-014-0116-9</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001630</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001630</idno><idno type="wicri:Area/Pmc/Curation">001490</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001490</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Right ventricle free wall mechanics in metabolic syndrome without type-2 diabetes: effects of a 3-month lifestyle intervention program</title><author><name sortKey="Serrano Ferrer, Juan" sort="Serrano Ferrer, Juan" uniqKey="Serrano Ferrer J" first="Juan" last="Serrano-Ferrer">Juan Serrano-Ferrer</name><affiliation wicri:level="1"><nlm:aff id="I1">Avignon University, Laboratoire de Pharm-Ecologie cardiovasculaire, LAPEC EA4278, Avignon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Avignon University, Laboratoire de Pharm-Ecologie cardiovasculaire, LAPEC EA4278, Avignon</wicri:regionArea></affiliation></author><author><name sortKey="Walther, Guillaume" sort="Walther, Guillaume" uniqKey="Walther G" first="Guillaume" last="Walther">Guillaume Walther</name><affiliation wicri:level="1"><nlm:aff id="I1">Avignon University, Laboratoire de Pharm-Ecologie cardiovasculaire, LAPEC EA4278, Avignon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Avignon University, Laboratoire de Pharm-Ecologie cardiovasculaire, LAPEC EA4278, Avignon</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Australian Catholic University, School of Exercise Science, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Catholic University, School of Exercise Science, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Crendal, Edward" sort="Crendal, Edward" uniqKey="Crendal E" first="Edward" last="Crendal">Edward Crendal</name><affiliation wicri:level="1"><nlm:aff id="I1">Avignon University, Laboratoire de Pharm-Ecologie cardiovasculaire, LAPEC EA4278, Avignon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Avignon University, Laboratoire de Pharm-Ecologie cardiovasculaire, LAPEC EA4278, Avignon</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Australian Catholic University, School of Exercise Science, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Catholic University, School of Exercise Science, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Vinet, Agnes" sort="Vinet, Agnes" uniqKey="Vinet A" first="Agnès" last="Vinet">Agnès Vinet</name><affiliation wicri:level="1"><nlm:aff id="I1">Avignon University, Laboratoire de Pharm-Ecologie cardiovasculaire, LAPEC EA4278, Avignon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Avignon University, Laboratoire de Pharm-Ecologie cardiovasculaire, LAPEC EA4278, Avignon</wicri:regionArea></affiliation></author><author><name sortKey="Dutheil, Frederic" sort="Dutheil, Frederic" uniqKey="Dutheil F" first="Frédéric" last="Dutheil">Frédéric Dutheil</name><affiliation wicri:level="1"><nlm:aff id="I2">Australian Catholic University, School of Exercise Science, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Catholic University, School of Exercise Science, Melbourne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I3">Blaise Pascal University, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions (AME2P), Clermont-Ferrand, EA3533, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Blaise Pascal University, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions (AME2P), Clermont-Ferrand, EA3533</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I4">University Hospital of Clermont-Ferrand CHU, Clermont-Ferrand, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Hospital of Clermont-Ferrand CHU, Clermont-Ferrand</wicri:regionArea></affiliation></author><author><name sortKey="Naughton, Geraldine" sort="Naughton, Geraldine" uniqKey="Naughton G" first="Geraldine" last="Naughton">Geraldine Naughton</name><affiliation wicri:level="1"><nlm:aff id="I2">Australian Catholic University, School of Exercise Science, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Catholic University, School of Exercise Science, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Lesourd, Bruno" sort="Lesourd, Bruno" uniqKey="Lesourd B" first="Bruno" last="Lesourd">Bruno Lesourd</name><affiliation wicri:level="1"><nlm:aff id="I3">Blaise Pascal University, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions (AME2P), Clermont-Ferrand, EA3533, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Blaise Pascal University, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions (AME2P), Clermont-Ferrand, EA3533</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I4">University Hospital of Clermont-Ferrand CHU, Clermont-Ferrand, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Hospital of Clermont-Ferrand CHU, Clermont-Ferrand</wicri:regionArea></affiliation></author><author><name sortKey="Chapier, Robert" sort="Chapier, Robert" uniqKey="Chapier R" first="Robert" last="Chapier">Robert Chapier</name><affiliation wicri:level="1"><nlm:aff id="I5">Omental – Thermalia Center, Châtelguyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Omental – Thermalia Center, Châtelguyon</wicri:regionArea></affiliation></author><author><name sortKey="Courteix, Daniel" sort="Courteix, Daniel" uniqKey="Courteix D" first="Daniel" last="Courteix">Daniel Courteix</name><affiliation wicri:level="1"><nlm:aff id="I2">Australian Catholic University, School of Exercise Science, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Catholic University, School of Exercise Science, Melbourne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I3">Blaise Pascal University, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions (AME2P), Clermont-Ferrand, EA3533, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Blaise Pascal University, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions (AME2P), Clermont-Ferrand, EA3533</wicri:regionArea></affiliation></author><author><name sortKey="Obert, Philippe" sort="Obert, Philippe" uniqKey="Obert P" first="Philippe" last="Obert">Philippe Obert</name><affiliation wicri:level="1"><nlm:aff id="I1">Avignon University, Laboratoire de Pharm-Ecologie cardiovasculaire, LAPEC EA4278, Avignon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Avignon University, Laboratoire de Pharm-Ecologie cardiovasculaire, LAPEC EA4278, Avignon</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Australian Catholic University, School of Exercise Science, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Catholic University, School of Exercise Science, Melbourne</wicri:regionArea></affiliation></author></analytic><series><title level="j">Cardiovascular Diabetology</title><idno type="eISSN">1475-2840</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Growing evidence demonstrates subtle left ventricular myocardial dysfunction in patients with metabolic syndrome (MetS), with central obesity, glucose intolerance and inflammation emerging as important contributors. Whether these results can be translated to the right ventricle (RV) is not yet fully elucidated. Furthermore, although lifestyle intervention favorably impacts MetS components and inflammatory biomarkers, its effect on RV myocardial function remains unknown today.</p></sec><sec><title>Methods</title><p>Thirty-nine MetS adults free of diabetes were enrolled in a three month lifestyle intervention program including diet and physical exercise, and compared with forty healthy controls. Blood biochemistry, echocardiography including tissue Doppler imaging (TDI), and vector velocity imaging of the RV free wall to assess global longitudinal strain (GLS) and strain rates (SR) were obtained at baseline and after the intervention.</p></sec><sec><title>Results</title><p>Compared with controls, MetS patients presented similar right atrial and RV morphology but reduced systolic (P = 0.04) and early diastolic (P = 0.02) velocities of the tricuspid annulus. They showed attenuated RV GLS (−21.4 ± 4.5vs-25.7 ± 4.9%, P < 0.001) as well as early diastolic (P = 0.003) and systolic (P < 0.001) SR. Multiple regression analyses revealed log PAI-1 active, (P < 0.001), log adiponectin, (P = 0.01), LV mass indexed (P = 0.004) and central fat (P = 0.03) as independent predictors of RV GLS (R<sup>2</sup> = 0.46, P < 0.001). Biological markers of MetS and inflammation as well as RV GLS (−21.8 ± 3.8vs-24.3 ± 3.0%, P = 0.009) and systolic (P = 0.003) and early diastolic (P = 0.01) SR, but not TDI indexes, significantly improved after diet and exercise training, and vector velocity imaging data in MetS following the lifestyle intervention no longer differed from controls.</p></sec><sec><title>Conclusions</title><p>MetS is associated with subtle impairments in both RV free wall diastolic and systolic myocardial function which could be partly related to central-obesity induced changes in pro- and anti-inflammatory cytokines and left ventricular remodeling. The favorable impact of healthy dieting and physical activity on RV free wall mechanics indicates that cellular and sub-cellular alterations responsible for the RV myocardial abnormalities are probably not permanent and modifiable throughout adequate interventional strategies.</p></sec><sec><title>Trial registration</title><p>American National Institutes of Health database <ext-link ext-link-type="uri" xlink:href="NCT00917917">NCT00917917</ext-link>.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mottillo, S" uniqKey="Mottillo S">S Mottillo</name></author><author><name sortKey="Filion, Kb" uniqKey="Filion K">KB Filion</name></author><author><name sortKey="Genest, J" uniqKey="Genest J">J Genest</name></author><author><name sortKey="Joseph, L" uniqKey="Joseph L">L Joseph</name></author><author><name sortKey="Pilote, L" uniqKey="Pilote L">L Pilote</name></author><author><name sortKey="Poirier, P" uniqKey="Poirier P">P 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Cardiovasc Diabetol</journal-id><journal-id journal-id-type="iso-abbrev">Cardiovasc Diabetol</journal-id><journal-title-group><journal-title>Cardiovascular Diabetology</journal-title></journal-title-group><issn pub-type="epub">1475-2840</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25407698</article-id><article-id pub-id-type="pmc">4149206</article-id><article-id pub-id-type="publisher-id">s12933-014-0116-9</article-id><article-id pub-id-type="doi">10.1186/s12933-014-0116-9</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Investigation</subject></subj-group></article-categories><title-group><article-title>Right ventricle free wall mechanics in metabolic syndrome without type-2 diabetes: effects of a 3-month lifestyle intervention program</article-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes" id="A1"><name><surname>Serrano-Ferrer</surname><given-names>Juan</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>juan.serrano-ferrer@alumni.univ-avignon.fr</email></contrib><contrib contrib-type="author" equal-contrib="yes" id="A2"><name><surname>Walther</surname><given-names>Guillaume</given-names></name><xref ref-type="aff" rid="I1">1</xref><xref ref-type="aff" rid="I2">2</xref><email>guillaume.walther@univ-avignon.fr</email></contrib><contrib contrib-type="author" id="A3"><name><surname>Crendal</surname><given-names>Edward</given-names></name><xref ref-type="aff" rid="I1">1</xref><xref ref-type="aff" rid="I2">2</xref><email>edwardcrendal@gmail.com</email></contrib><contrib contrib-type="author" id="A4"><name><surname>Vinet</surname><given-names>Agnès</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>agnes.vinet@univ-avignon.fr</email></contrib><contrib contrib-type="author" id="A5"><name><surname>Dutheil</surname><given-names>Frédéric</given-names></name><xref ref-type="aff" rid="I2">2</xref><xref ref-type="aff" rid="I3">3</xref><xref ref-type="aff" rid="I4">4</xref><email>fred_dutheil@yahoo.fr</email></contrib><contrib contrib-type="author" corresp="yes" id="A6"><name><surname>Naughton</surname><given-names>Geraldine</given-names></name><xref ref-type="aff" rid="I2">2</xref><email>geraldine.Naughton@acu.edu.au</email></contrib><contrib contrib-type="author" id="A7"><name><surname>Lesourd</surname><given-names>Bruno</given-names></name><xref ref-type="aff" rid="I3">3</xref><xref ref-type="aff" rid="I4">4</xref><email>lesourd.bruno@orange.fr</email></contrib><contrib contrib-type="author" id="A8"><name><surname>Chapier</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="I5">5</xref><email>robertchapier@yahoo.fr</email></contrib><contrib contrib-type="author" id="A9"><name><surname>Courteix</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="I2">2</xref><xref ref-type="aff" rid="I3">3</xref><email>daniel.courteix@univ-bpclermont.fr</email></contrib><contrib contrib-type="author" id="A10"><name><surname>Obert</surname><given-names>Philippe</given-names></name><xref ref-type="aff" rid="I1">1</xref><xref ref-type="aff" rid="I2">2</xref><email>philippe.obert@univ-avignon.fr</email></contrib></contrib-group><aff id="I1"><label>1</label>Avignon University, Laboratoire de Pharm-Ecologie cardiovasculaire, LAPEC EA4278, Avignon, France</aff><aff id="I2"><label>2</label>Australian Catholic University, School of Exercise Science, Melbourne, Australia</aff><aff id="I3"><label>3</label>Blaise Pascal University, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions (AME2P), Clermont-Ferrand, EA3533, France</aff><aff id="I4"><label>4</label>University Hospital of Clermont-Ferrand CHU, Clermont-Ferrand, France</aff><aff id="I5"><label>5</label>Omental – Thermalia Center, Châtelguyon, France</aff><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>3</day><month>8</month><year>2014</year></pub-date><volume>13</volume><fpage>116</fpage><lpage>116</lpage><history><date date-type="received"><day>23</day><month>5</month><year>2014</year></date><date date-type="accepted"><day>20</day><month>7</month><year>2014</year></date></history><permissions><copyright-statement>Copyright © 2014 Serrano et al.; licensee BioMed Central Ltd.</copyright-statement><copyright-year>2014</copyright-year><copyright-holder>Serrano et al.; licensee BioMed Central Ltd.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0">http://creativecommons.org/licenses/by/4.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><self-uri xlink:href="http://www.cardiab.com/content/13/1/116"></self-uri><abstract><sec><title>Background</title><p>Growing evidence demonstrates subtle left ventricular myocardial dysfunction in patients with metabolic syndrome (MetS), with central obesity, glucose intolerance and inflammation emerging as important contributors. Whether these results can be translated to the right ventricle (RV) is not yet fully elucidated. Furthermore, although lifestyle intervention favorably impacts MetS components and inflammatory biomarkers, its effect on RV myocardial function remains unknown today.</p></sec><sec><title>Methods</title><p>Thirty-nine MetS adults free of diabetes were enrolled in a three month lifestyle intervention program including diet and physical exercise, and compared with forty healthy controls. Blood biochemistry, echocardiography including tissue Doppler imaging (TDI), and vector velocity imaging of the RV free wall to assess global longitudinal strain (GLS) and strain rates (SR) were obtained at baseline and after the intervention.</p></sec><sec><title>Results</title><p>Compared with controls, MetS patients presented similar right atrial and RV morphology but reduced systolic (P = 0.04) and early diastolic (P = 0.02) velocities of the tricuspid annulus. They showed attenuated RV GLS (−21.4 ± 4.5vs-25.7 ± 4.9%, P < 0.001) as well as early diastolic (P = 0.003) and systolic (P < 0.001) SR. Multiple regression analyses revealed log PAI-1 active, (P < 0.001), log adiponectin, (P = 0.01), LV mass indexed (P = 0.004) and central fat (P = 0.03) as independent predictors of RV GLS (R<sup>2</sup> = 0.46, P < 0.001). Biological markers of MetS and inflammation as well as RV GLS (−21.8 ± 3.8vs-24.3 ± 3.0%, P = 0.009) and systolic (P = 0.003) and early diastolic (P = 0.01) SR, but not TDI indexes, significantly improved after diet and exercise training, and vector velocity imaging data in MetS following the lifestyle intervention no longer differed from controls.</p></sec><sec><title>Conclusions</title><p>MetS is associated with subtle impairments in both RV free wall diastolic and systolic myocardial function which could be partly related to central-obesity induced changes in pro- and anti-inflammatory cytokines and left ventricular remodeling. The favorable impact of healthy dieting and physical activity on RV free wall mechanics indicates that cellular and sub-cellular alterations responsible for the RV myocardial abnormalities are probably not permanent and modifiable throughout adequate interventional strategies.</p></sec><sec><title>Trial registration</title><p>American National Institutes of Health database <ext-link ext-link-type="uri" xlink:href="NCT00917917">NCT00917917</ext-link>.</p></sec></abstract><kwd-group><kwd>Metabolic syndrome</kwd><kwd>Right ventricle</kwd><kwd>Speckle tracking</kwd><kwd>Lifestyle intervention</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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