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Mental Disorders as Risk factors for Substance Use, Abuse and Dependence: Results from the 10-year Follow-up of the National Comorbidity Survey

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Mental Disorders as Risk factors for Substance Use, Abuse and Dependence: Results from the 10-year Follow-up of the National Comorbidity Survey

Auteurs : Joel Swendsen [France] ; Kevin P. Conway [États-Unis] ; Louisa Degenhardt [Australie] ; Meyer Glantz [États-Unis] ; Robert Jin [États-Unis] ; Kathleen R. Merikangas [États-Unis] ; Nancy Sampson [États-Unis] ; Ronald C. Kessler [États-Unis]

Source :

Addiction (Abingdon, England) [ 0965-2140 ] ; 2010.

RBID : PMC:2910819

Abstract

Aims

The comorbidity of mental disorders and substance dependence is well-documented, but prospective investigations in community samples are rare. This investigation examines the role of primary mental disorders as risk factors for the later onset of nicotine, alcohol and illicit drug use, abuse, and dependence with abuse.

Design

The NCS was a nationally representative survey of mental and substance disorders in the US carried out in 1990 1992. The NCS-2 re-interviewed a probability sub-sample of NCS respondents in 2001-2003, a decade after the baseline survey.

Participants

A total of 5,001 NCS respondents were re-interviewed in the NCS-2 (87.6% of baseline sample).

Results

Aggregate analyses demonstrated significant prospective risks posed by baseline mental disorders for the onset of nicotine, alcohol and illicit drug dependence with abuse over the follow-up period. Particularly strong and consistent associations were observed for behavioral disorders and previous substance use conditions, as well as for certain mood and anxiety disorders. Conditional analyses demonstrated that many observed associations were limited to specific categories of use, abuse or dependence, including several mental disorders that were nonsignificant predictors in the aggregate analyses. Results suggest that secondary substance use disorders might be reduced substantially through the prevention of primary mental disorders.

Conclusions

Many mental disorders are associated with an increased risk of later substance use conditions but important differences in these associations are observed across the categories of use, abuse and dependence with abuse. These prospective findings have implications for the precision of prevention and treatment strategies targeting substance use disorders.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910819

DOI: 10.1111/j.1360-0443.2010.02902.x
PubMed: 20331554
PubMed Central: 2910819

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PMC:2910819

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<sec id="S2"><title>Design</title>
<p id="P2">The NCS was a nationally representative survey of mental and substance disorders in the US carried out in 1990 1992. The NCS-2 re-interviewed a probability sub-sample of NCS respondents in 2001-2003, a decade after the baseline survey.</p>
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<sec id="S3"><title>Participants</title>
<p id="P3">A total of 5,001 NCS respondents were re-interviewed in the NCS-2 (87.6% of baseline sample).</p>
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<sec id="S4"><title>Results</title>
<p id="P4">Aggregate analyses demonstrated significant prospective risks posed by baseline mental disorders for the onset of nicotine, alcohol and illicit drug dependence with abuse over the follow-up period. Particularly strong and consistent associations were observed for behavioral disorders and previous substance use conditions, as well as for certain mood and anxiety disorders. Conditional analyses demonstrated that many observed associations were limited to specific categories of use, abuse or dependence, including several mental disorders that were nonsignificant predictors in the aggregate analyses. Results suggest that secondary substance use disorders might be reduced substantially through the prevention of primary mental disorders.</p>
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National Scientific Research Center, Bordeaux, France</aff>
<aff id="A2"><label>2</label>
Division of Epidemiology, Services, and Prevention Research, National Institute on Drug Abuse, National Institutes of Health, USA</aff>
<aff id="A3"><label>3</label>
National Drug and Alcohol Research Centre, University of NSW, Sydney, Australia</aff>
<aff id="A4"><label>4</label>
Department of Health Policy, Harvard Medical School, Boston, Massachusetts, USA</aff>
<aff id="A5"><label>5</label>
Intramural Research Program of the National Institutes of Health, National Institute of Mental Health, Bethesda, Maryland, USA</aff>
<author-notes><corresp id="FN1">Corresponding author: Joel Swendsen, CNRS 5231), University of Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux, France, <email>Joel.Swendsen@u-bordeaux2.fr</email>
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<issue>6</issue>
<fpage>1117</fpage>
<lpage>1128</lpage>
<abstract><sec id="S1"><title>Aims</title>
<p id="P1">The comorbidity of mental disorders and substance dependence is well-documented, but prospective investigations in community samples are rare. This investigation examines the role of primary mental disorders as risk factors for the later onset of nicotine, alcohol and illicit drug use, abuse, and dependence with abuse.</p>
</sec>
<sec id="S2"><title>Design</title>
<p id="P2">The NCS was a nationally representative survey of mental and substance disorders in the US carried out in 1990 1992. The NCS-2 re-interviewed a probability sub-sample of NCS respondents in 2001-2003, a decade after the baseline survey.</p>
</sec>
<sec id="S3"><title>Participants</title>
<p id="P3">A total of 5,001 NCS respondents were re-interviewed in the NCS-2 (87.6% of baseline sample).</p>
</sec>
<sec id="S4"><title>Results</title>
<p id="P4">Aggregate analyses demonstrated significant prospective risks posed by baseline mental disorders for the onset of nicotine, alcohol and illicit drug dependence with abuse over the follow-up period. Particularly strong and consistent associations were observed for behavioral disorders and previous substance use conditions, as well as for certain mood and anxiety disorders. Conditional analyses demonstrated that many observed associations were limited to specific categories of use, abuse or dependence, including several mental disorders that were nonsignificant predictors in the aggregate analyses. Results suggest that secondary substance use disorders might be reduced substantially through the prevention of primary mental disorders.</p>
</sec>
<sec id="S5"><title>Conclusions</title>
<p id="P5">Many mental disorders are associated with an increased risk of later substance use conditions but important differences in these associations are observed across the categories of use, abuse and dependence with abuse. These prospective findings have implications for the precision of prevention and treatment strategies targeting substance use disorders.</p>
</sec>
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Mental Disorders as Risk factors for Substance Use, Abuse and Dependence: Results from the 10-year Follow-up of the National Comorbidity Survey

Mental Disorders as Risk factors for Substance Use, Abuse and Dependence: Results from the 10-year Follow-up of the National Comorbidity Survey

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Abstract

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