Lessons from the Fourth Metronomic and Anti-angiogenic Therapy Meeting, 24–25 June 2014, Milan
Identifieur interne : 001185 ( Pmc/Curation ); précédent : 001184; suivant : 001186Lessons from the Fourth Metronomic and Anti-angiogenic Therapy Meeting, 24–25 June 2014, Milan
Auteurs : Gauthier Bouche [Belgique] ; Nicolas André [France] ; Shripad Banavali [Inde] ; Frank Berthold [Allemagne] ; Alfredo Berruti [Italie] ; Guido Bocci [Italie] ; Giovanni Brandi [Italie] ; Ugo Cavallaro [Italie] ; Saviero Cinieri [Italie] ; Marco Colleoni [Italie] ; Giuseppe Curigliano [Italie] ; Teresa Di Desidero [Italie] ; Alexandru Eniu [Roumanie] ; Nicola Fazio [Italie] ; Robert Kerbel [Canada] ; Lisa Hutchinson [Royaume-Uni] ; Urszula Ledzewicz [États-Unis] ; Elisabetta Munzone [Italie] ; Eddy Pasquier [France] ; O. Graciela Scharovsky [Argentine] ; Yuval Shaked [Israël] ; Jaroslav Št Rba [République tchèque] ; Martin Villalba [France] ; Francesco Bertolini [Italie]Source :
- ecancermedicalscience [ 1754-6605 ] ; 2014.
Abstract
The Fourth Metronomic and Anti-angiogenic Therapy Meeting was held in Milan 24–25 June 2014. The meeting was a true translational meeting where researchers and clinicians shared their results, experiences, and insights in order to continue gathering useful evidence on metronomic approaches. Several speakers emphasised that exact mechanisms of action, best timing, and optimal dosage are still not well understood and that the field would learn a lot from ancillary studies performed during the clinical trials of metronomic chemotherapies. From the pre-clinical side, new research findings indicate additional possible mechanisms of actions of metronomic schedule on the immune and blood vessel compartments of the tumour micro-environment. New clinical results of metronomic chemotherapy were presented in particular in paediatric cancers [especially neuroblastoma and central nervous system (CNS) tumours], in angiosarcoma (together with beta-blockers), in hepatocellular carcinoma, in prostate cancer, and in breast cancer. The use of repurposed drugs such as metformin, celecoxib, or valproic acid in the metronomic regimen was reported and highlighted the potential of other candidate drugs to be repurposed. The clinical experiences from low- and middle-income countries with affordable regimens gave very encouraging results which will allow more patients to be effectively treated in economies where new drugs are not accessible. Looking at the impact of metronomic approaches that have been shown to be effective, it was admitted that those approaches were rarely used in clinical practice, in part because of the absence of commercial interest for companies. However, performing well-designed clinical trials of metronomic and repurposing approaches demonstrating substantial improvement, especially in populations with the greatest unmet needs, may be an easier solution than addressing the financial issue. Metronomics should always be seen as a chance to come up with new innovative affordable approaches and not as a cheap rescue strategy.
Url:
DOI: 10.3332/ecancer.2014.463
PubMed: 25228919
PubMed Central: 4162678
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Lessons from the Fourth Metronomic and Anti-angiogenic Therapy Meeting, 24–25 June 2014, Milan</title>
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<author><name sortKey="Eniu, Alexandru" sort="Eniu, Alexandru" uniqKey="Eniu A" first="Alexandru" last="Eniu">Alexandru Eniu</name>
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<author><name sortKey="Ledzewicz, Urszula" sort="Ledzewicz, Urszula" uniqKey="Ledzewicz U" first="Urszula" last="Ledzewicz">Urszula Ledzewicz</name>
<affiliation wicri:level="1"><nlm:aff id="aff16">Department of Mathematics and Statistics, Southern Illinois University, Edwardsville, IL 62026, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Mathematics and Statistics, Southern Illinois University, Edwardsville, IL 62026</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Munzone, Elisabetta" sort="Munzone, Elisabetta" uniqKey="Munzone E" first="Elisabetta" last="Munzone">Elisabetta Munzone</name>
<affiliation wicri:level="1"><nlm:aff id="aff17">Division of Medical Senology, European Institute of Oncology, Milan 20141, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Division of Medical Senology, European Institute of Oncology, Milan 20141</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pasquier, Eddy" sort="Pasquier, Eddy" uniqKey="Pasquier E" first="Eddy" last="Pasquier">Eddy Pasquier</name>
<affiliation wicri:level="1"><nlm:aff id="aff18"> Tumour Biology and Targeting Programme, Children’s Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick 2031, Australia; Metronomics Global Health Initiative, Marseille 13005, France; & Centre for Research in Oncobiology and Oncopharmacology, INSERM UMR911, Marseille 13005, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Tumour Biology and Targeting Programme, Children’s Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick 2031, Australia; Metronomics Global Health Initiative, Marseille 13005, France; & Centre for Research in Oncobiology and Oncopharmacology, INSERM UMR911, Marseille 13005</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Graciela Scharovsky, O" sort="Graciela Scharovsky, O" uniqKey="Graciela Scharovsky O" first="O" last="Graciela Scharovsky">O. Graciela Scharovsky</name>
<affiliation wicri:level="1"><nlm:aff id="aff19"> Jefa Sección Oncología Experimental, Instituto de Genética Experimental, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, 2000, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea> Jefa Sección Oncología Experimental, Instituto de Genética Experimental, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, 2000</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Shaked, Yuval" sort="Shaked, Yuval" uniqKey="Shaked Y" first="Yuval" last="Shaked">Yuval Shaked</name>
<affiliation wicri:level="1"><nlm:aff id="aff20">Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Rappaport Faculty of Medicine, Technion, Haifa 31096</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="St Rba, Jaroslav" sort="St Rba, Jaroslav" uniqKey="St Rba J" first="Jaroslav" last="Št Rba">Jaroslav Št Rba</name>
<affiliation wicri:level="1"><nlm:aff id="aff21">Department of Pediatric Oncology, Masaryk University School of Medicine and University Hospital, Brno, Cernopolni 9 Brno 613 00, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Department of Pediatric Oncology, Masaryk University School of Medicine and University Hospital, Brno, Cernopolni 9 Brno 613 00</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Villalba, Martin" sort="Villalba, Martin" uniqKey="Villalba M" first="Martin" last="Villalba">Martin Villalba</name>
<affiliation wicri:level="1"><nlm:aff id="aff22"> INSERM U1040, Université de Montpellier 1, UFR Médecine, Montpellier 34295, France & Institute for Regenerative Medicine and Biotherapy (IRMB), CHU Montpellier, Montpellier 34295, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> INSERM U1040, Université de Montpellier 1, UFR Médecine, Montpellier 34295, France & Institute for Regenerative Medicine and Biotherapy (IRMB), CHU Montpellier, Montpellier 34295</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bertolini, Francesco" sort="Bertolini, Francesco" uniqKey="Bertolini F" first="Francesco" last="Bertolini">Francesco Bertolini</name>
<affiliation wicri:level="1"><nlm:aff id="aff23">Laboratory of Haematology-Oncology, European Institute of Oncology, Milan 20141, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Laboratory of Haematology-Oncology, European Institute of Oncology, Milan 20141</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">ecancermedicalscience</title>
<idno type="eISSN">1754-6605</idno>
<imprint><date when="2014">2014</date>
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<front><div type="abstract" xml:lang="en"><p>The Fourth Metronomic and Anti-angiogenic Therapy Meeting was held in Milan 24–25 June 2014. The meeting was a true translational meeting where researchers and clinicians shared their results, experiences, and insights in order to continue gathering useful evidence on metronomic approaches. Several speakers emphasised that exact mechanisms of action, best timing, and optimal dosage are still not well understood and that the field would learn a lot from ancillary studies performed during the clinical trials of metronomic chemotherapies. From the pre-clinical side, new research findings indicate additional possible mechanisms of actions of metronomic schedule on the immune and blood vessel compartments of the tumour micro-environment. New clinical results of metronomic chemotherapy were presented in particular in paediatric cancers [especially neuroblastoma and central nervous system (CNS) tumours], in angiosarcoma (together with beta-blockers), in hepatocellular carcinoma, in prostate cancer, and in breast cancer. The use of repurposed drugs such as metformin, celecoxib, or valproic acid in the metronomic regimen was reported and highlighted the potential of other candidate drugs to be repurposed. The clinical experiences from low- and middle-income countries with affordable regimens gave very encouraging results which will allow more patients to be effectively treated in economies where new drugs are not accessible. Looking at the impact of metronomic approaches that have been shown to be effective, it was admitted that those approaches were rarely used in clinical practice, in part because of the absence of commercial interest for companies. However, performing well-designed clinical trials of metronomic and repurposing approaches demonstrating substantial improvement, especially in populations with the greatest unmet needs, may be an easier solution than addressing the financial issue. Metronomics should always be seen as a chance to come up with new innovative affordable approaches and not as a cheap rescue strategy.</p>
</div>
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<pmc article-type="meeting-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Ecancermedicalscience</journal-id>
<journal-id journal-id-type="iso-abbrev">Ecancermedicalscience</journal-id>
<journal-id journal-id-type="publisher-id">ecancermedicalscience</journal-id>
<journal-title-group><journal-title>ecancermedicalscience</journal-title>
</journal-title-group>
<issn pub-type="epub">1754-6605</issn>
<publisher><publisher-name>Cancer Intelligence</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25228919</article-id>
<article-id pub-id-type="pmc">4162678</article-id>
<article-id pub-id-type="doi">10.3332/ecancer.2014.463</article-id>
<article-id pub-id-type="publisher-id">can-8-463</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Conference Report</subject>
</subj-group>
</article-categories>
<title-group><article-title>Lessons from the Fourth Metronomic and Anti-angiogenic Therapy Meeting, 24–25 June 2014, Milan</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Bouche</surname>
<given-names>Gauthier</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>André</surname>
<given-names>Nicolas</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Banavali</surname>
<given-names>Shripad</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Berthold</surname>
<given-names>Frank</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Berruti</surname>
<given-names>Alfredo</given-names>
</name>
<xref ref-type="aff" rid="aff5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bocci</surname>
<given-names>Guido</given-names>
</name>
<xref ref-type="aff" rid="aff6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brandi</surname>
<given-names>Giovanni</given-names>
</name>
<xref ref-type="aff" rid="aff7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cavallaro</surname>
<given-names>Ugo</given-names>
</name>
<xref ref-type="aff" rid="aff8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cinieri</surname>
<given-names>Saviero</given-names>
</name>
<xref ref-type="aff" rid="aff9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Colleoni</surname>
<given-names>Marco</given-names>
</name>
<xref ref-type="aff" rid="aff10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Curigliano</surname>
<given-names>Giuseppe</given-names>
</name>
<xref ref-type="aff" rid="aff11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Desidero</surname>
<given-names>Teresa Di</given-names>
</name>
<xref ref-type="aff" rid="aff6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Eniu</surname>
<given-names>Alexandru</given-names>
</name>
<xref ref-type="aff" rid="aff12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fazio</surname>
<given-names>Nicola</given-names>
</name>
<xref ref-type="aff" rid="aff13">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kerbel</surname>
<given-names>Robert</given-names>
</name>
<xref ref-type="aff" rid="aff14">14</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hutchinson</surname>
<given-names>Lisa</given-names>
</name>
<xref ref-type="aff" rid="aff15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ledzewicz</surname>
<given-names>Urszula</given-names>
</name>
<xref ref-type="aff" rid="aff16">16</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Munzone</surname>
<given-names>Elisabetta</given-names>
</name>
<xref ref-type="aff" rid="aff17">17</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pasquier</surname>
<given-names>Eddy</given-names>
</name>
<xref ref-type="aff" rid="aff18">18</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Graciela Scharovsky</surname>
<given-names>O</given-names>
</name>
<xref ref-type="aff" rid="aff19">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shaked</surname>
<given-names>Yuval</given-names>
</name>
<xref ref-type="aff" rid="aff20">20</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Štěrba</surname>
<given-names>Jaroslav</given-names>
</name>
<xref ref-type="aff" rid="aff21">21</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Villalba</surname>
<given-names>Martin</given-names>
</name>
<xref ref-type="aff" rid="aff22">22</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bertolini</surname>
<given-names>Francesco</given-names>
</name>
<xref ref-type="aff" rid="aff23">23</xref>
</contrib>
<aff id="aff1"><label>1</label>
Anticancer Fund, Strombeek-Bever B1853, Belgium</aff>
<aff id="aff2"><label>2</label>
Metronomics Global Health Initiative; Aix Marseille Université, Inserm, CRO2 UMR_S 911; & Paediatric Haematology and Oncology Department, Children’s Hospital of La Timone, Marseille 13005, France</aff>
<aff id="aff3"><label>3</label>
Tata Memorial Centre, Mumbai 400012, India</aff>
<aff id="aff4"><label>4</label>
Department of Paediatric Oncology, University of Cologne D50924, Germany</aff>
<aff id="aff5"><label>5</label>
Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Azienda Ospedaliera Spedali Civili, Brescia 25123, Italy</aff>
<aff id="aff6"><label>6</label>
Division of Pharmacology, Department of Clinical and Experimental Medicine, University of Pisa, via Roma 55, Pisa 56126, Italy</aff>
<aff id="aff7"><label>7</label>
Department of Experimental, Diagnostic and Specialty Medicine University Hospital S. Orsola-Malpighi Bologna, 40138, Italy</aff>
<aff id="aff8"><label>8</label>
Molecular Medicine Programme, European Institute of Oncology, Milan 20141, Italy</aff>
<aff id="aff9"><label>9</label>
Medical Oncology Department, Brindisi 72100, Italy</aff>
<aff id="aff10"><label>10</label>
Division of Medical Senology, European Institute of Oncology, European Institute of Oncology, Milan 20141, Italy</aff>
<aff id="aff11"><label>11</label>
Division of Experimental Therapeutics, European Institute of Oncology, Milan 20141, Italy</aff>
<aff id="aff12"><label>12</label>
Cancer Institute ‘I. Chiricuta’, Cluj-Napoca 400015, Romania</aff>
<aff id="aff13"><label>13</label>
Unit of Gastrointestinal Medical Oncology and Neuroendocrine Unit, European Institute of Oncology, Milan 20141, Italy</aff>
<aff id="aff14"><label>14</label>
Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto M4N 3M5, Canada</aff>
<aff id="aff15"><label>15</label>
Nature Reviews Clinical Oncology, London N1 9XW, UK</aff>
<aff id="aff16"><label>16</label>
Department of Mathematics and Statistics, Southern Illinois University, Edwardsville, IL 62026, USA</aff>
<aff id="aff17"><label>17</label>
Division of Medical Senology, European Institute of Oncology, Milan 20141, Italy</aff>
<aff id="aff18"><label>18</label>
Tumour Biology and Targeting Programme, Children’s Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick 2031, Australia; Metronomics Global Health Initiative, Marseille 13005, France; & Centre for Research in Oncobiology and Oncopharmacology, INSERM UMR911, Marseille 13005, France</aff>
<aff id="aff19"><label>19</label>
Jefa Sección Oncología Experimental, Instituto de Genética Experimental, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, 2000, Argentina</aff>
<aff id="aff20"><label>20</label>
Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel</aff>
<aff id="aff21"><label>21</label>
Department of Pediatric Oncology, Masaryk University School of Medicine and University Hospital, Brno, Cernopolni 9 Brno 613 00, Czech Republic</aff>
<aff id="aff22"><label>22</label>
INSERM U1040, Université de Montpellier 1, UFR Médecine, Montpellier 34295, France & Institute for Regenerative Medicine and Biotherapy (IRMB), CHU Montpellier, Montpellier 34295, France</aff>
<aff id="aff23"><label>23</label>
Laboratory of Haematology-Oncology, European Institute of Oncology, Milan 20141, Italy</aff>
</contrib-group>
<author-notes><corresp id="c1-can-8-463"><bold>Correspondence to:</bold>
Francesco Bertolini; Nicolas André. <email>francesco.bertolini@ieo.it; nicolas.andre@ap-hm.fr</email>
</corresp>
</author-notes>
<pub-date pub-type="collection"><year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>09</day>
<month>9</month>
<year>2014</year>
</pub-date>
<volume>8</volume>
<elocation-id>463</elocation-id>
<history><date date-type="received"><day>28</day>
<month>7</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>© the authors; licensee ecancermedicalscience.</copyright-statement>
<copyright-year>2014</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/3.0"><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/3.0">http://creativecommons.org/licenses/by/3.0</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><p>The Fourth Metronomic and Anti-angiogenic Therapy Meeting was held in Milan 24–25 June 2014. The meeting was a true translational meeting where researchers and clinicians shared their results, experiences, and insights in order to continue gathering useful evidence on metronomic approaches. Several speakers emphasised that exact mechanisms of action, best timing, and optimal dosage are still not well understood and that the field would learn a lot from ancillary studies performed during the clinical trials of metronomic chemotherapies. From the pre-clinical side, new research findings indicate additional possible mechanisms of actions of metronomic schedule on the immune and blood vessel compartments of the tumour micro-environment. New clinical results of metronomic chemotherapy were presented in particular in paediatric cancers [especially neuroblastoma and central nervous system (CNS) tumours], in angiosarcoma (together with beta-blockers), in hepatocellular carcinoma, in prostate cancer, and in breast cancer. The use of repurposed drugs such as metformin, celecoxib, or valproic acid in the metronomic regimen was reported and highlighted the potential of other candidate drugs to be repurposed. The clinical experiences from low- and middle-income countries with affordable regimens gave very encouraging results which will allow more patients to be effectively treated in economies where new drugs are not accessible. Looking at the impact of metronomic approaches that have been shown to be effective, it was admitted that those approaches were rarely used in clinical practice, in part because of the absence of commercial interest for companies. However, performing well-designed clinical trials of metronomic and repurposing approaches demonstrating substantial improvement, especially in populations with the greatest unmet needs, may be an easier solution than addressing the financial issue. Metronomics should always be seen as a chance to come up with new innovative affordable approaches and not as a cheap rescue strategy.</p>
</abstract>
<kwd-group><kwd>metronomic chemotherapy</kwd>
<kwd>cancer</kwd>
<kwd>drug repurposing</kwd>
<kwd>anti-angiogenesis</kwd>
<kwd>pharmacoeconomics</kwd>
<kwd>adult</kwd>
<kwd>child</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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