Distinct immune responses of juvenile and adult oysters (Crassostrea gigas) to viral and bacterial infections
Identifieur interne : 000D20 ( Pmc/Curation ); précédent : 000D19; suivant : 000D21Distinct immune responses of juvenile and adult oysters (Crassostrea gigas) to viral and bacterial infections
Auteurs : Timothy J. Green [France] ; Agnes Vergnes [France] ; Caroline Montagnani [France] ; Julien De Lorgeril [France]Source :
- Veterinary Research [ 0928-4249 ] ; 2016.
Abstract
Since 2008, massive mortality events of Pacific oysters (
The online version of this article (doi:10.1186/s13567-016-0356-7) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s13567-016-0356-7
PubMed: 27439510
PubMed Central: 4955271
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Timothy J. Green<affiliation><nlm:aff id="Aff2">Department of Biological Sciences, Macquarie University, Sydney, NSW 2109 Australia</nlm:aff>
<wicri:noCountry code="subfield">NSW 2109 Australia</wicri:noCountry>
</affiliation>
Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Distinct immune responses of juvenile and adult oysters (<italic>Crassostrea gigas</italic>
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<affiliation><nlm:aff id="Aff2">Department of Biological Sciences, Macquarie University, Sydney, NSW 2109 Australia</nlm:aff>
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<author><name sortKey="Vergnes, Agnes" sort="Vergnes, Agnes" uniqKey="Vergnes A" first="Agnes" last="Vergnes">Agnes Vergnes</name>
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<series><title level="j">Veterinary Research</title>
<idno type="ISSN">0928-4249</idno>
<idno type="eISSN">1297-9716</idno>
<imprint><date when="2016">2016</date>
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<front><div type="abstract" xml:lang="en"><p>Since 2008, massive mortality events of Pacific oysters (<italic>Crassostrea gigas</italic>
) have been reported worldwide and these disease events are often associated with Ostreid herpesvirus type 1 (OsHV-1). Epidemiological field studies have also reported oyster age and other pathogens of the <italic>Vibrio</italic>
genus are contributing factors to this syndrome. We undertook a controlled laboratory experiment to simultaneously investigate survival and immunological response of juvenile and adult <italic>C. gigas</italic>
at different time-points post-infection with OsHV-1, <italic>Vibrio tasmaniensis</italic>
LGP32 and <italic>V. aestuarianus</italic>
. Our data corroborates epidemiological studies that juveniles are more susceptible to OsHV-1, whereas adults are more susceptible to <italic>Vibrio</italic>
. We measured the expression of 102 immune-genes by high-throughput RT-qPCR, which revealed oysters have different transcriptional responses to OsHV-1 and <italic>Vibrio</italic>
. The transcriptional response in the early stages of OsHV-1 infection involved genes related to apoptosis and the interferon-pathway. Transcriptional response to <italic>Vibrio</italic>
infection involved antimicrobial peptides, heat shock proteins and galectins. Interestingly, oysters in the later stages of OsHV-1 infection had a transcriptional response that resembled an antibacterial response, which is suggestive of the oyster’s microbiome causing secondary infections (dysbiosis-driven pathology). This study provides molecular evidence that oysters can mount distinct immune response to viral and bacterial pathogens and these responses differ depending on the age of the host.</p>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/s13567-016-0356-7) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Vet Res</journal-id>
<journal-id journal-id-type="iso-abbrev">Vet. Res</journal-id>
<journal-title-group><journal-title>Veterinary Research</journal-title>
</journal-title-group>
<issn pub-type="ppub">0928-4249</issn>
<issn pub-type="epub">1297-9716</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">27439510</article-id>
<article-id pub-id-type="pmc">4955271</article-id>
<article-id pub-id-type="publisher-id">356</article-id>
<article-id pub-id-type="doi">10.1186/s13567-016-0356-7</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Distinct immune responses of juvenile and adult oysters (<italic>Crassostrea gigas</italic>
) to viral and bacterial infections</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Green</surname>
<given-names>Timothy J.</given-names>
</name>
<address><email>tim.green@mq.edu.au</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
<xref ref-type="aff" rid="Aff2"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vergnes</surname>
<given-names>Agnes</given-names>
</name>
<address><email>avergnes@ifremer.fr</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Montagnani</surname>
<given-names>Caroline</given-names>
</name>
<address><email>cmontagn@ifremer.fr</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>de Lorgeril</surname>
<given-names>Julien</given-names>
</name>
<address><email>jdelorge@ifremer.fr</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<aff id="Aff1"><label></label>
IFREMER, IHPE, UMR 5244, Univ. Perpignan Via Domitia, CNRS, Univ. Montpellier, 34095 Montpellier, France</aff>
<aff id="Aff2"><label></label>
Department of Biological Sciences, Macquarie University, Sydney, NSW 2109 Australia</aff>
</contrib-group>
<pub-date pub-type="epub"><day>21</day>
<month>7</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>21</day>
<month>7</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="ppub"><year>2016</year>
</pub-date>
<volume>47</volume>
<elocation-id>72</elocation-id>
<history><date date-type="received"><day>27</day>
<month>1</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>2</day>
<month>5</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s) 2016</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<abstract id="Abs1"><p>Since 2008, massive mortality events of Pacific oysters (<italic>Crassostrea gigas</italic>
) have been reported worldwide and these disease events are often associated with Ostreid herpesvirus type 1 (OsHV-1). Epidemiological field studies have also reported oyster age and other pathogens of the <italic>Vibrio</italic>
genus are contributing factors to this syndrome. We undertook a controlled laboratory experiment to simultaneously investigate survival and immunological response of juvenile and adult <italic>C. gigas</italic>
at different time-points post-infection with OsHV-1, <italic>Vibrio tasmaniensis</italic>
LGP32 and <italic>V. aestuarianus</italic>
. Our data corroborates epidemiological studies that juveniles are more susceptible to OsHV-1, whereas adults are more susceptible to <italic>Vibrio</italic>
. We measured the expression of 102 immune-genes by high-throughput RT-qPCR, which revealed oysters have different transcriptional responses to OsHV-1 and <italic>Vibrio</italic>
. The transcriptional response in the early stages of OsHV-1 infection involved genes related to apoptosis and the interferon-pathway. Transcriptional response to <italic>Vibrio</italic>
infection involved antimicrobial peptides, heat shock proteins and galectins. Interestingly, oysters in the later stages of OsHV-1 infection had a transcriptional response that resembled an antibacterial response, which is suggestive of the oyster’s microbiome causing secondary infections (dysbiosis-driven pathology). This study provides molecular evidence that oysters can mount distinct immune response to viral and bacterial pathogens and these responses differ depending on the age of the host.</p>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/s13567-016-0356-7) contains supplementary material, which is available to authorized users.</p>
</sec>
</abstract>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2016</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
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