Acute respiratory infections in hospitalized children in Vientiane, Lao PDR – the importance of Respiratory Syncytial Virus
Identifieur interne : 000C94 ( Pmc/Curation ); précédent : 000C93; suivant : 000C95Acute respiratory infections in hospitalized children in Vientiane, Lao PDR – the importance of Respiratory Syncytial Virus
Auteurs : Van Hoan Nguyen [France, Viêt Nam] ; Audrey Dubot-Pérès [France, Royaume-Uni] ; Fiona M. Russell [Australie] ; David A. B. Dance [Royaume-Uni] ; Keoudomphone Vilivong ; Souphatsone Phommachan ; Chanthaphone Syladeth ; Jana Lai [Australie] ; Ruth Lim [Australie] ; Melinda Morpeth [Australie] ; Mayfong Mayxay [Laos] ; Paul N. Newton [Royaume-Uni] ; Hervé Richet [France] ; Xavier De Lamballerie [France]Source :
- Scientific Reports [ 2045-2322 ] ; 2017.
Abstract
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Url:
DOI: 10.1038/s41598-017-09006-6
PubMed: 28839157
PubMed Central: 5571090
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Audrey Dubot-Pérès<affiliation><nlm:aff id="Aff4">Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR</nlm:aff><wicri:noCountry code="subfield">Lao PDR</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id><institution-id institution-id-type="GRID">grid.4991.5</institution-id><institution>Centre for Tropical Medicine and Global Health,</institution><institution>Nuffield Department of Clinical Medicine, Old Road Campus, University of Oxford,</institution></institution-wrap>Oxford, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford</wicri:regionArea></affiliation><affiliation><nlm:aff id="Aff4">Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR</nlm:aff><wicri:noCountry code="subfield">Lao PDR</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id><institution-id institution-id-type="GRID">grid.4991.5</institution-id><institution>Centre for Tropical Medicine and Global Health,</institution><institution>Nuffield Department of Clinical Medicine, Old Road Campus, University of Oxford,</institution></institution-wrap>Oxford, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0425 469X</institution-id><institution-id institution-id-type="GRID">grid.8991.9</institution-id><institution>Faculty of Infectious and Tropical Diseases,</institution><institution>London School of Hygiene and Tropical Medicine,</institution></institution-wrap>London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation><affiliation><nlm:aff id="Aff4">Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR</nlm:aff><wicri:noCountry code="subfield">Lao PDR</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff4">Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR</nlm:aff><wicri:noCountry code="subfield">Lao PDR</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff4">Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR</nlm:aff><wicri:noCountry code="subfield">Lao PDR</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff4">Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR</nlm:aff><wicri:noCountry code="subfield">Lao PDR</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff11"><institution-wrap><institution-id institution-id-type="GRID">grid.412958.3</institution-id><institution>Faculty of Postgraduate Studies,</institution><institution>University of Health Sciences, Vientiane, Lao PDR,</institution></institution-wrap>Vientiane, Laos</nlm:aff><country xml:lang="fr">Laos</country><wicri:regionArea>Vientiane</wicri:regionArea></affiliation><affiliation><nlm:aff id="Aff4">Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR</nlm:aff><wicri:noCountry code="subfield">Lao PDR</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id><institution-id institution-id-type="GRID">grid.4991.5</institution-id><institution>Centre for Tropical Medicine and Global Health,</institution><institution>Nuffield Department of Clinical Medicine, Old Road Campus, University of Oxford,</institution></institution-wrap>Oxford, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford</wicri:regionArea></affiliation>Le document en format XML
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Dance</name><affiliation><nlm:aff id="Aff4">Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR</nlm:aff><wicri:noCountry code="subfield">Lao PDR</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id><institution-id institution-id-type="GRID">grid.4991.5</institution-id><institution>Centre for Tropical Medicine and Global Health,</institution><institution>Nuffield Department of Clinical Medicine, Old Road Campus, University of Oxford,</institution></institution-wrap>Oxford, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0425 469X</institution-id><institution-id 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Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR</nlm:aff><wicri:noCountry code="subfield">Lao PDR</wicri:noCountry></affiliation></author><author><name sortKey="Syladeth, Chanthaphone" sort="Syladeth, Chanthaphone" uniqKey="Syladeth C" first="Chanthaphone" last="Syladeth">Chanthaphone Syladeth</name><affiliation><nlm:aff id="Aff4">Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR</nlm:aff><wicri:noCountry code="subfield">Lao PDR</wicri:noCountry></affiliation></author><author><name sortKey="Lai, Jana" sort="Lai, Jana" uniqKey="Lai J" first="Jana" last="Lai">Jana Lai</name><affiliation wicri:level="1"><nlm:aff id="Aff7">Pneumococcal Research Group, Murdoch Childrens Research Institute, The Royal Children’s Hospital, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Pneumococcal Research Group, Murdoch Childrens Research Institute, The Royal Children’s Hospital, 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Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Morpeth, Melinda" sort="Morpeth, Melinda" uniqKey="Morpeth M" first="Melinda" last="Morpeth">Melinda Morpeth</name><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2179 088X</institution-id><institution-id institution-id-type="GRID">grid.1008.9</institution-id><institution>Dept. of Paediatrics,</institution><institution>The University of Melbourne,</institution></institution-wrap>Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0614 0346</institution-id><institution-id institution-id-type="GRID">grid.416107.5</institution-id><institution></institution><institution>The Royal Children’s Hospital,</institution></institution-wrap>Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Mayxay, Mayfong" sort="Mayxay, Mayfong" uniqKey="Mayxay M" first="Mayfong" last="Mayxay">Mayfong Mayxay</name><affiliation><nlm:aff id="Aff4">Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR</nlm:aff><wicri:noCountry code="subfield">Lao PDR</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff11"><institution-wrap><institution-id institution-id-type="GRID">grid.412958.3</institution-id><institution>Faculty of Postgraduate Studies,</institution><institution>University of Health Sciences, Vientiane, Lao PDR,</institution></institution-wrap>Vientiane, Laos</nlm:aff><country xml:lang="fr">Laos</country><wicri:regionArea>Vientiane</wicri:regionArea></affiliation></author><author><name sortKey="Newton, Paul N" sort="Newton, Paul N" uniqKey="Newton P" first="Paul N." last="Newton">Paul N. Newton</name><affiliation><nlm:aff id="Aff4">Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR</nlm:aff><wicri:noCountry code="subfield">Lao PDR</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id><institution-id institution-id-type="GRID">grid.4991.5</institution-id><institution>Centre for Tropical Medicine and Global Health,</institution><institution>Nuffield Department of Clinical Medicine, Old Road Campus, University of Oxford,</institution></institution-wrap>Oxford, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Richet, Herve" sort="Richet, Herve" uniqKey="Richet H" first="Hervé" last="Richet">Hervé Richet</name><affiliation wicri:level="1"><nlm:aff id="Aff1">UMR “Emergence des Pathologies Virales” (EPV: Aix-Marseille university - IRD190 - Inserm 1207 - EHESP), Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR “Emergence des Pathologies Virales” (EPV: Aix-Marseille university - IRD190 - Inserm 1207 - EHESP), Marseille</wicri:regionArea></affiliation></author><author><name sortKey="De Lamballerie, Xavier" sort="De Lamballerie, Xavier" uniqKey="De Lamballerie X" first="Xavier" last="De Lamballerie">Xavier De Lamballerie</name><affiliation wicri:level="1"><nlm:aff id="Aff1">UMR “Emergence des Pathologies Virales” (EPV: Aix-Marseille university - IRD190 - Inserm 1207 - EHESP), Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR “Emergence des Pathologies Virales” (EPV: Aix-Marseille university - IRD190 - Inserm 1207 - EHESP), Marseille</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">Institut hospitalo-universitaire Méditerranée infection, APHM Public Hospitals of Marseille, Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut hospitalo-universitaire Méditerranée infection, APHM Public Hospitals of Marseille, Marseille</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28839157</idno><idno type="pmc">5571090</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571090</idno><idno type="RBID">PMC:5571090</idno><idno type="doi">10.1038/s41598-017-09006-6</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000E33</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E33</idno><idno type="wicri:Area/Pmc/Curation">000C94</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C94</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Acute respiratory infections in hospitalized children in Vientiane, Lao PDR – the importance of Respiratory Syncytial Virus</title><author><name sortKey="Nguyen, Van Hoan" sort="Nguyen, Van Hoan" uniqKey="Nguyen V" first="Van Hoan" last="Nguyen">Van Hoan Nguyen</name><affiliation wicri:level="1"><nlm:aff id="Aff1">UMR “Emergence des Pathologies Virales” (EPV: Aix-Marseille university - IRD190 - Inserm 1207 - EHESP), Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR “Emergence des Pathologies Virales” (EPV: Aix-Marseille university - IRD190 - Inserm 1207 - EHESP), Marseille</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">Institut hospitalo-universitaire Méditerranée infection, APHM Public Hospitals of Marseille, Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut hospitalo-universitaire Méditerranée infection, APHM Public Hospitals of Marseille, Marseille</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0315 8231</institution-id><institution-id institution-id-type="GRID">grid.444923.c</institution-id><institution>Department of Infectious Diseases,</institution><institution>Hai Phong University of Medicine and Pharmacy,</institution></institution-wrap>Hai Phong, Vietnam</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Hai Phong</wicri:regionArea></affiliation></author><author><name sortKey="Dubot Peres, Audrey" sort="Dubot Peres, Audrey" uniqKey="Dubot Peres A" first="Audrey" last="Dubot-Pérès">Audrey Dubot-Pérès</name><affiliation wicri:level="1"><nlm:aff id="Aff1">UMR “Emergence des Pathologies Virales” (EPV: Aix-Marseille university - IRD190 - Inserm 1207 - EHESP), Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR “Emergence des Pathologies Virales” (EPV: Aix-Marseille university - IRD190 - Inserm 1207 - EHESP), Marseille</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">Institut hospitalo-universitaire Méditerranée infection, APHM Public Hospitals of Marseille, Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut hospitalo-universitaire Méditerranée infection, APHM Public Hospitals of Marseille, Marseille</wicri:regionArea></affiliation><affiliation><nlm:aff id="Aff4">Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR</nlm:aff><wicri:noCountry code="subfield">Lao PDR</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id><institution-id institution-id-type="GRID">grid.4991.5</institution-id><institution>Centre for Tropical Medicine and Global Health,</institution><institution>Nuffield Department of Clinical Medicine, Old Road Campus, University of Oxford,</institution></institution-wrap>Oxford, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Russell, Fiona M" sort="Russell, Fiona M" uniqKey="Russell F" first="Fiona M." last="Russell">Fiona M. Russell</name><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2179 088X</institution-id><institution-id institution-id-type="GRID">grid.1008.9</institution-id><institution>Dept. of Paediatrics,</institution><institution>The University of Melbourne,</institution></institution-wrap>Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff7">Pneumococcal Research Group, Murdoch Childrens Research Institute, The Royal Children’s Hospital, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Pneumococcal Research Group, Murdoch Childrens Research Institute, The Royal Children’s Hospital, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Dance, David A B" sort="Dance, David A B" uniqKey="Dance D" first="David A. B." last="Dance">David A. B. Dance</name><affiliation><nlm:aff id="Aff4">Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR</nlm:aff><wicri:noCountry code="subfield">Lao PDR</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id><institution-id institution-id-type="GRID">grid.4991.5</institution-id><institution>Centre for Tropical Medicine and Global Health,</institution><institution>Nuffield Department of Clinical Medicine, Old Road Campus, University of Oxford,</institution></institution-wrap>Oxford, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0425 469X</institution-id><institution-id institution-id-type="GRID">grid.8991.9</institution-id><institution>Faculty of Infectious and Tropical Diseases,</institution><institution>London School of Hygiene and Tropical Medicine,</institution></institution-wrap>London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Vilivong, Keoudomphone" sort="Vilivong, Keoudomphone" uniqKey="Vilivong K" first="Keoudomphone" last="Vilivong">Keoudomphone Vilivong</name><affiliation><nlm:aff id="Aff4">Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR</nlm:aff><wicri:noCountry code="subfield">Lao PDR</wicri:noCountry></affiliation></author><author><name sortKey="Phommachan, Souphatsone" sort="Phommachan, Souphatsone" uniqKey="Phommachan S" first="Souphatsone" last="Phommachan">Souphatsone Phommachan</name><affiliation><nlm:aff id="Aff4">Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR</nlm:aff><wicri:noCountry code="subfield">Lao PDR</wicri:noCountry></affiliation></author><author><name sortKey="Syladeth, Chanthaphone" sort="Syladeth, Chanthaphone" uniqKey="Syladeth C" first="Chanthaphone" last="Syladeth">Chanthaphone Syladeth</name><affiliation><nlm:aff id="Aff4">Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR</nlm:aff><wicri:noCountry code="subfield">Lao PDR</wicri:noCountry></affiliation></author><author><name sortKey="Lai, Jana" sort="Lai, Jana" uniqKey="Lai J" first="Jana" last="Lai">Jana Lai</name><affiliation wicri:level="1"><nlm:aff id="Aff7">Pneumococcal Research Group, Murdoch Childrens Research Institute, The Royal Children’s Hospital, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Pneumococcal Research Group, Murdoch Childrens Research Institute, The Royal Children’s Hospital, Melbourne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 7477</institution-id><institution-id institution-id-type="GRID">grid.1001.0</institution-id><institution>National Centre for Epidemiology & Population Health,</institution><institution>Australian National University,</institution></institution-wrap>Canberra, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Canberra</wicri:regionArea></affiliation></author><author><name sortKey="Lim, Ruth" sort="Lim, Ruth" uniqKey="Lim R" first="Ruth" last="Lim">Ruth Lim</name><affiliation wicri:level="1"><nlm:aff id="Aff7">Pneumococcal Research Group, Murdoch Childrens Research Institute, The Royal Children’s Hospital, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Pneumococcal Research Group, Murdoch Childrens Research Institute, The Royal Children’s Hospital, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Morpeth, Melinda" sort="Morpeth, Melinda" uniqKey="Morpeth M" first="Melinda" last="Morpeth">Melinda Morpeth</name><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2179 088X</institution-id><institution-id institution-id-type="GRID">grid.1008.9</institution-id><institution>Dept. of Paediatrics,</institution><institution>The University of Melbourne,</institution></institution-wrap>Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0614 0346</institution-id><institution-id institution-id-type="GRID">grid.416107.5</institution-id><institution></institution><institution>The Royal Children’s Hospital,</institution></institution-wrap>Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Mayxay, Mayfong" sort="Mayxay, Mayfong" uniqKey="Mayxay M" first="Mayfong" last="Mayxay">Mayfong Mayxay</name><affiliation><nlm:aff id="Aff4">Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR</nlm:aff><wicri:noCountry code="subfield">Lao PDR</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff11"><institution-wrap><institution-id institution-id-type="GRID">grid.412958.3</institution-id><institution>Faculty of Postgraduate Studies,</institution><institution>University of Health Sciences, Vientiane, Lao PDR,</institution></institution-wrap>Vientiane, Laos</nlm:aff><country xml:lang="fr">Laos</country><wicri:regionArea>Vientiane</wicri:regionArea></affiliation></author><author><name sortKey="Newton, Paul N" sort="Newton, Paul N" uniqKey="Newton P" first="Paul N." last="Newton">Paul N. Newton</name><affiliation><nlm:aff id="Aff4">Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR</nlm:aff><wicri:noCountry code="subfield">Lao PDR</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id><institution-id institution-id-type="GRID">grid.4991.5</institution-id><institution>Centre for Tropical Medicine and Global Health,</institution><institution>Nuffield Department of Clinical Medicine, Old Road Campus, University of Oxford,</institution></institution-wrap>Oxford, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Richet, Herve" sort="Richet, Herve" uniqKey="Richet H" first="Hervé" last="Richet">Hervé Richet</name><affiliation wicri:level="1"><nlm:aff id="Aff1">UMR “Emergence des Pathologies Virales” (EPV: Aix-Marseille university - IRD190 - Inserm 1207 - EHESP), Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR “Emergence des Pathologies Virales” (EPV: Aix-Marseille university - IRD190 - Inserm 1207 - EHESP), Marseille</wicri:regionArea></affiliation></author><author><name sortKey="De Lamballerie, Xavier" sort="De Lamballerie, Xavier" uniqKey="De Lamballerie X" first="Xavier" last="De Lamballerie">Xavier De Lamballerie</name><affiliation wicri:level="1"><nlm:aff id="Aff1">UMR “Emergence des Pathologies Virales” (EPV: Aix-Marseille university - IRD190 - Inserm 1207 - EHESP), Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR “Emergence des Pathologies Virales” (EPV: Aix-Marseille university - IRD190 - Inserm 1207 - EHESP), Marseille</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">Institut hospitalo-universitaire Méditerranée infection, APHM Public Hospitals of Marseille, Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut hospitalo-universitaire Méditerranée infection, APHM Public Hospitals of Marseille, Marseille</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">The <italic>Human respiratory syncytial virus</italic> (RSV) is one of the most important viral pathogens, causing epidemics of acute respiratory infection (ARI), especially bronchiolitis and pneumonia, in children worldwide. To investigate the RSV burden in Laos, we conducted a one-year study in children <5 years old admitted to Mahosot Hospital, Vientiane Capital, to describe clinical and epidemiological characteristics and predictive factors for severity of RSV-associated ARI. Pooled nasal and throat swabs were tested using multiplex real-time PCR for 33 respiratory pathogens (FTD<sup>®</sup> kit). A total of 383 patients were included, 277 (72.3%) of whom presented with pneumonia. 377 (98.4%) patients were positive for at least one microorganism, of which RSV was the most common virus (41.0%), with a peak observed between June and September, corresponding to the rainy season. Most RSV inpatients had pneumonia (84.1%), of whom 35% had severe pneumonia. Children <3-months old were a high-risk group for severe pneumonia, independently of RSV infection. Our study suggests that RSV infection is frequent in Laos and commonly associated with pneumonia in hospitalized young children. Further investigations are required to provide a better overall view of the Lao nationwide epidemiology and public health burden of RSV infection over time.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Legand, A" uniqKey="Legand A">A Legand</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Rudan, I" uniqKey="Rudan I">I Rudan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruuskanen, O" uniqKey="Ruuskanen O">O Ruuskanen</name></author><author><name sortKey="Lahti, E" uniqKey="Lahti E">E Lahti</name></author><author><name sortKey="Jennings, Lc" uniqKey="Jennings L">LC Jennings</name></author><author><name sortKey="Murdoch, Dr" uniqKey="Murdoch D">DR Murdoch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nair, H" uniqKey="Nair H">H Nair</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Piedimonte, G" uniqKey="Piedimonte G">G Piedimonte</name></author><author><name sortKey="Perez, Mk" uniqKey="Perez M">MK Perez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weber, Mw" uniqKey="Weber M">MW Weber</name></author><author><name sortKey="Mulholland, Ek" uniqKey="Mulholland E">EK Mulholland</name></author><author><name sortKey="Greenwood, Bm" uniqKey="Greenwood B">BM Greenwood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giersing, Bk" uniqKey="Giersing B">BK Giersing</name></author><author><name sortKey="Modjarrad, K" uniqKey="Modjarrad K">K Modjarrad</name></author><author><name sortKey="Kaslow, Dc" uniqKey="Kaslow D">DC Kaslow</name></author><author><name sortKey="Moorthy, Vs" uniqKey="Moorthy V">VS Moorthy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Modjarrad, K" uniqKey="Modjarrad K">K Modjarrad</name></author><author><name sortKey="Giersing, B" uniqKey="Giersing B">B Giersing</name></author><author><name sortKey="Kaslow, Dc" uniqKey="Kaslow D">DC Kaslow</name></author><author><name sortKey="Smith, Pg" uniqKey="Smith P">PG Smith</name></author><author><name sortKey="Moorthy, Vs" uniqKey="Moorthy V">VS Moorthy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Jy" uniqKey="Kim J">JY Kim</name></author><author><name sortKey="Chang, J" uniqKey="Chang J">J Chang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vongphrachanh, P" uniqKey="Vongphrachanh P">P Vongphrachanh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sentilhes, A C" uniqKey="Sentilhes A">A-C Sentilhes</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Hasan, R" uniqKey="Hasan R">R Hasan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Olsen, Sj" uniqKey="Olsen S">SJ Olsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Do, Ahl" uniqKey="Do A">AHL Do</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haynes, Ak" uniqKey="Haynes A">AK Haynes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rodriguez, Da" uniqKey="Rodriguez D">DA Rodríguez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paynter, S" uniqKey="Paynter S">S Paynter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Homaira, N" uniqKey="Homaira N">N Homaira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Naorat, S" uniqKey="Naorat S">S Naorat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turner, C" uniqKey="Turner C">C Turner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, X" uniqKey="Yu X">X Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nair, H" uniqKey="Nair H">H Nair</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Bosch, Aatm" uniqKey="Bosch A">AATM Bosch</name></author><author><name sortKey="Biesbroek, G" uniqKey="Biesbroek G">G Biesbroek</name></author><author><name sortKey="Trzcinski, K" uniqKey="Trzcinski K">K Trzcinski</name></author><author><name sortKey="Sanders, Eam" uniqKey="Sanders E">EAM Sanders</name></author><author><name sortKey="Bogaert, D" uniqKey="Bogaert D">D Bogaert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nguyen, Dt" uniqKey="Nguyen D">DT Nguyen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pascalis, H" uniqKey="Pascalis H">H Pascalis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Queir Z, Dao" uniqKey="Queir Z D">DaO Queiróz</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Sci Rep</journal-id><journal-id journal-id-type="iso-abbrev">Sci Rep</journal-id><journal-title-group><journal-title>Scientific Reports</journal-title></journal-title-group><issn pub-type="epub">2045-2322</issn><publisher><publisher-name>Nature Publishing Group UK</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28839157</article-id><article-id pub-id-type="pmc">5571090</article-id><article-id pub-id-type="publisher-id">9006</article-id><article-id pub-id-type="doi">10.1038/s41598-017-09006-6</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Acute respiratory infections in hospitalized children in Vientiane, Lao PDR – the importance of Respiratory Syncytial Virus</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Nguyen</surname><given-names>Van Hoan</given-names></name><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff2">2</xref><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Dubot-Pérès</surname><given-names>Audrey</given-names></name><address><email>audrey@tropmedres.ac</email></address><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff2">2</xref><xref ref-type="aff" rid="Aff4">4</xref><xref ref-type="aff" rid="Aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Russell</surname><given-names>Fiona M.</given-names></name><xref ref-type="aff" rid="Aff6">6</xref><xref ref-type="aff" rid="Aff7">7</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0001-9189-7244</contrib-id><name><surname>Dance</surname><given-names>David A. B.</given-names></name><xref ref-type="aff" rid="Aff4">4</xref><xref ref-type="aff" rid="Aff5">5</xref><xref ref-type="aff" rid="Aff8">8</xref></contrib><contrib contrib-type="author"><name><surname>Vilivong</surname><given-names>Keoudomphone</given-names></name><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Phommachan</surname><given-names>Souphatsone</given-names></name><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Syladeth</surname><given-names>Chanthaphone</given-names></name><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Lai</surname><given-names>Jana</given-names></name><xref ref-type="aff" rid="Aff7">7</xref><xref ref-type="aff" rid="Aff9">9</xref></contrib><contrib contrib-type="author"><name><surname>Lim</surname><given-names>Ruth</given-names></name><xref ref-type="aff" rid="Aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Morpeth</surname><given-names>Melinda</given-names></name><xref ref-type="aff" rid="Aff6">6</xref><xref ref-type="aff" rid="Aff10">10</xref></contrib><contrib contrib-type="author"><name><surname>Mayxay</surname><given-names>Mayfong</given-names></name><xref ref-type="aff" rid="Aff4">4</xref><xref ref-type="aff" rid="Aff11">11</xref></contrib><contrib contrib-type="author"><name><surname>Newton</surname><given-names>Paul N.</given-names></name><xref ref-type="aff" rid="Aff4">4</xref><xref ref-type="aff" rid="Aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Richet</surname><given-names>Hervé</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0001-7895-2720</contrib-id><name><surname>De Lamballerie</surname><given-names>Xavier</given-names></name><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff2">2</xref></contrib><aff id="Aff1"><label>1</label>UMR “Emergence des Pathologies Virales” (EPV: Aix-Marseille university - IRD190 - Inserm 1207 - EHESP), Marseille, France</aff><aff id="Aff2"><label>2</label>Institut hospitalo-universitaire Méditerranée infection, APHM Public Hospitals of Marseille, Marseille, France</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0315 8231</institution-id><institution-id institution-id-type="GRID">grid.444923.c</institution-id><institution>Department of Infectious Diseases,</institution><institution>Hai Phong University of Medicine and Pharmacy,</institution></institution-wrap>Hai Phong, Vietnam</aff><aff id="Aff4"><label>4</label>Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR</aff><aff id="Aff5"><label>5</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id><institution-id institution-id-type="GRID">grid.4991.5</institution-id><institution>Centre for Tropical Medicine and Global Health,</institution><institution>Nuffield Department of Clinical Medicine, Old Road Campus, University of Oxford,</institution></institution-wrap>Oxford, United Kingdom</aff><aff id="Aff6"><label>6</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2179 088X</institution-id><institution-id institution-id-type="GRID">grid.1008.9</institution-id><institution>Dept. of Paediatrics,</institution><institution>The University of Melbourne,</institution></institution-wrap>Melbourne, Australia</aff><aff id="Aff7"><label>7</label>Pneumococcal Research Group, Murdoch Childrens Research Institute, The Royal Children’s Hospital, Melbourne, Australia</aff><aff id="Aff8"><label>8</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0425 469X</institution-id><institution-id institution-id-type="GRID">grid.8991.9</institution-id><institution>Faculty of Infectious and Tropical Diseases,</institution><institution>London School of Hygiene and Tropical Medicine,</institution></institution-wrap>London, UK</aff><aff id="Aff9"><label>9</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 7477</institution-id><institution-id institution-id-type="GRID">grid.1001.0</institution-id><institution>National Centre for Epidemiology & Population Health,</institution><institution>Australian National University,</institution></institution-wrap>Canberra, Australia</aff><aff id="Aff10"><label>10</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0614 0346</institution-id><institution-id institution-id-type="GRID">grid.416107.5</institution-id><institution></institution><institution>The Royal Children’s Hospital,</institution></institution-wrap>Melbourne, Australia</aff><aff id="Aff11"><label>11</label><institution-wrap><institution-id institution-id-type="GRID">grid.412958.3</institution-id><institution>Faculty of Postgraduate Studies,</institution><institution>University of Health Sciences, Vientiane, Lao PDR,</institution></institution-wrap>Vientiane, Laos</aff></contrib-group><pub-date pub-type="epub"><day>24</day><month>8</month><year>2017</year></pub-date><pub-date pub-type="pmc-release"><day>24</day><month>8</month><year>2017</year></pub-date><pub-date pub-type="collection"><year>2017</year></pub-date><volume>7</volume><elocation-id>9318</elocation-id><history><date date-type="received"><day>22</day><month>3</month><year>2017</year></date><date date-type="accepted"><day>14</day><month>7</month><year>2017</year></date></history><permissions><copyright-statement>© The Author(s) 2017</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold> This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>.</license-p></license></permissions><abstract id="Abs1"><p id="Par1">The <italic>Human respiratory syncytial virus</italic> (RSV) is one of the most important viral pathogens, causing epidemics of acute respiratory infection (ARI), especially bronchiolitis and pneumonia, in children worldwide. To investigate the RSV burden in Laos, we conducted a one-year study in children <5 years old admitted to Mahosot Hospital, Vientiane Capital, to describe clinical and epidemiological characteristics and predictive factors for severity of RSV-associated ARI. Pooled nasal and throat swabs were tested using multiplex real-time PCR for 33 respiratory pathogens (FTD<sup>®</sup> kit). A total of 383 patients were included, 277 (72.3%) of whom presented with pneumonia. 377 (98.4%) patients were positive for at least one microorganism, of which RSV was the most common virus (41.0%), with a peak observed between June and September, corresponding to the rainy season. Most RSV inpatients had pneumonia (84.1%), of whom 35% had severe pneumonia. Children <3-months old were a high-risk group for severe pneumonia, independently of RSV infection. Our study suggests that RSV infection is frequent in Laos and commonly associated with pneumonia in hospitalized young children. Further investigations are required to provide a better overall view of the Lao nationwide epidemiology and public health burden of RSV infection over time.</p></abstract><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2017</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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