Abdominal infections in the intensive care unit: characteristics, treatment and determinants of outcome
Identifieur interne : 000A68 ( Pmc/Curation ); précédent : 000A67; suivant : 000A69Abdominal infections in the intensive care unit: characteristics, treatment and determinants of outcome
Auteurs : Jan De Waele [Belgique] ; Jeffrey Lipman ; Yasser Sakr [Allemagne] ; John C. Marshall [Canada] ; Philippe Vanhems [France] ; Casiano Barrera Groba ; Marc Leone [France] ; Jean-Louis Vincent [Belgique]Source :
- BMC Infectious Diseases [ 1471-2334 ] ; 2014.
Abstract
Abdominal infections are frequent causes of sepsis and septic shock in the intensive care unit (ICU) and are associated with adverse outcomes. We analyzed the characteristics, treatments and outcome of ICU patients with abdominal infections using data extracted from a one-day point prevalence study, the Extended Prevalence of Infection in the ICU (EPIC) II.
EPIC II included 13,796 adult patients from 1,265 ICUs in 75 countries. Infection was defined using the International Sepsis Forum criteria. Microbiological analyses were performed locally. Participating ICUs provided patient follow-up until hospital discharge or for 60 days.
Of the 7,087 infected patients, 1,392 (19.6%) had an abdominal infection on the study day (60% male, mean age 62 ± 16 years, SAPS II score 39 ± 16, SOFA score 7.6 ± 4.6). Microbiological cultures were positive in 931 (67%) patients, most commonly Gram-negative bacteria (48.0%). Antibiotics were administered to 1366 (98.1%) patients. Patients who had been in the ICU for ≤2 days prior to the study day had more
The characteristics, microbiology and antibiotic treatment of abdominal infections in critically ill patients are diverse. Mortality in patients with isolated abdominal infections was higher than in those who had other infections.
The online version of this article (doi:10.1186/1471-2334-14-420) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/1471-2334-14-420
PubMed: 25074742
PubMed Central: 4122779
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Jeffrey Lipman<affiliation><nlm:aff id="Aff2">Department of Intensive Care Medicine, Royal Brisbane and Women’s Hospital, The University of Queensland, Butterfield St, Herston, QLD 4029 Australia</nlm:aff>
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</affiliation>
<affiliation><nlm:aff id="Aff6">Department of Intensive Care, Brighton and Sussex University Hospitals NHS Trust, Royal Sussex County Hospital, Eastern Road, East Sussex, Brighton BN2 5BE UK</nlm:aff>
<wicri:noCountry code="subfield">Brighton BN2 5BE UK</wicri:noCountry>
</affiliation>
Le document en format XML
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<author><name sortKey="Vincent, Jean Louis" sort="Vincent, Jean Louis" uniqKey="Vincent J" first="Jean-Louis" last="Vincent">Jean-Louis Vincent</name>
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<series><title level="j">BMC Infectious Diseases</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Abdominal infections are frequent causes of sepsis and septic shock in the intensive care unit (ICU) and are associated with adverse outcomes. We analyzed the characteristics, treatments and outcome of ICU patients with abdominal infections using data extracted from a one-day point prevalence study, the Extended Prevalence of Infection in the ICU (EPIC) II.</p>
</sec>
<sec><title>Methods</title>
<p>EPIC II included 13,796 adult patients from 1,265 ICUs in 75 countries. Infection was defined using the International Sepsis Forum criteria. Microbiological analyses were performed locally. Participating ICUs provided patient follow-up until hospital discharge or for 60 days.</p>
</sec>
<sec><title>Results</title>
<p>Of the 7,087 infected patients, 1,392 (19.6%) had an abdominal infection on the study day (60% male, mean age 62 ± 16 years, SAPS II score 39 ± 16, SOFA score 7.6 ± 4.6). Microbiological cultures were positive in 931 (67%) patients, most commonly Gram-negative bacteria (48.0%). Antibiotics were administered to 1366 (98.1%) patients. Patients who had been in the ICU for ≤2 days prior to the study day had more <italic>Escherichia coli</italic>
, methicillin-sensitive <italic>Staphylococcus aureus</italic>
and anaerobic isolates, and fewer enterococci than patients who had been in the ICU longer<italic>.</italic>
ICU and hospital mortality rates were 29.4% and 36.3%, respectively. ICU mortality was higher in patients with abdominal infections than in those with other infections (29.4% vs. 24.4%, p < 0.001). In multivariable analysis, hematological malignancy, mechanical ventilation, cirrhosis, need for renal replacement therapy and SAPS II score were independently associated with increased mortality.</p>
</sec>
<sec><title>Conclusions</title>
<p>The characteristics, microbiology and antibiotic treatment of abdominal infections in critically ill patients are diverse. Mortality in patients with isolated abdominal infections was higher than in those who had other infections.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/1471-2334-14-420) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Vincent, Jl" uniqKey="Vincent J">JL Vincent</name>
</author>
<author><name sortKey="Rello, J" uniqKey="Rello J">J Rello</name>
</author>
<author><name sortKey="Marshall, J" uniqKey="Marshall J">J Marshall</name>
</author>
<author><name sortKey="Silva, E" uniqKey="Silva E">E Silva</name>
</author>
<author><name sortKey="Anzueto, A" uniqKey="Anzueto A">A Anzueto</name>
</author>
<author><name sortKey="Martin, Cd" uniqKey="Martin C">CD Martin</name>
</author>
<author><name sortKey="Moreno, R" uniqKey="Moreno R">R Moreno</name>
</author>
<author><name sortKey="Lipman, J" uniqKey="Lipman J">J Lipman</name>
</author>
<author><name sortKey="Gomersall, C" uniqKey="Gomersall C">C Gomersall</name>
</author>
<author><name sortKey="Sakr, Y" uniqKey="Sakr Y">Y Sakr</name>
</author>
<author><name sortKey="Reinhart, K" uniqKey="Reinhart K">K Reinhart</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vincent, Jl" uniqKey="Vincent J">JL Vincent</name>
</author>
<author><name sortKey="Bihari, Dj" uniqKey="Bihari D">DJ Bihari</name>
</author>
<author><name sortKey="Suter, Pm" uniqKey="Suter P">PM Suter</name>
</author>
<author><name sortKey="Bruining, Ha" uniqKey="Bruining H">HA Bruining</name>
</author>
<author><name sortKey="White, J" uniqKey="White J">J White</name>
</author>
<author><name sortKey="Nicolas Chanoin, Mh" uniqKey="Nicolas Chanoin M">MH Nicolas-Chanoin</name>
</author>
<author><name sortKey="Wolff, M" uniqKey="Wolff M">M Wolff</name>
</author>
<author><name sortKey="Spencer, Rc" uniqKey="Spencer R">RC Spencer</name>
</author>
<author><name sortKey="Hemmer, M" uniqKey="Hemmer M">M Hemmer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Finfer, S" uniqKey="Finfer S">S Finfer</name>
</author>
<author><name sortKey="Bellomo, R" uniqKey="Bellomo R">R Bellomo</name>
</author>
<author><name sortKey="Lipman, J" uniqKey="Lipman J">J Lipman</name>
</author>
<author><name sortKey="French, C" uniqKey="French C">C French</name>
</author>
<author><name sortKey="Dobb, G" uniqKey="Dobb G">G Dobb</name>
</author>
<author><name sortKey="Myburgh, J" uniqKey="Myburgh J">J Myburgh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ranieri, Vm" uniqKey="Ranieri V">VM Ranieri</name>
</author>
<author><name sortKey="Thompson, Bt" uniqKey="Thompson B">BT Thompson</name>
</author>
<author><name sortKey="Barie, Ps" uniqKey="Barie P">PS Barie</name>
</author>
<author><name sortKey="Dhainaut, Jf" uniqKey="Dhainaut J">JF Dhainaut</name>
</author>
<author><name sortKey="Douglas, Is" uniqKey="Douglas I">IS Douglas</name>
</author>
<author><name sortKey="Finfer, S" uniqKey="Finfer S">S Finfer</name>
</author>
<author><name sortKey="Gardlund, B" uniqKey="Gardlund B">B Gardlund</name>
</author>
<author><name sortKey="Marshall, Jc" uniqKey="Marshall J">JC Marshall</name>
</author>
<author><name sortKey="Rhodes, A" uniqKey="Rhodes A">A Rhodes</name>
</author>
<author><name sortKey="Artigas, A" uniqKey="Artigas A">A Artigas</name>
</author>
<author><name sortKey="Payen, D" uniqKey="Payen D">D Payen</name>
</author>
<author><name sortKey="Tenhunen, J" uniqKey="Tenhunen J">J Tenhunen</name>
</author>
<author><name sortKey="Al Khalidi, Hr" uniqKey="Al Khalidi H">HR Al-Khalidi</name>
</author>
<author><name sortKey="Thompson, V" uniqKey="Thompson V">V Thompson</name>
</author>
<author><name sortKey="Janes, J" uniqKey="Janes J">J Janes</name>
</author>
<author><name sortKey="Macias, Wl" uniqKey="Macias W">WL Macias</name>
</author>
<author><name sortKey="Vangerow, B" uniqKey="Vangerow B">B Vangerow</name>
</author>
<author><name sortKey="Williams, Md" uniqKey="Williams M">MD Williams</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vincent, Jl" uniqKey="Vincent J">JL Vincent</name>
</author>
<author><name sortKey="Sakr, Y" uniqKey="Sakr Y">Y Sakr</name>
</author>
<author><name sortKey="Sprung, Cl" uniqKey="Sprung C">CL Sprung</name>
</author>
<author><name sortKey="Ranieri, Vm" uniqKey="Ranieri V">VM Ranieri</name>
</author>
<author><name sortKey="Reinhart, K" uniqKey="Reinhart K">K Reinhart</name>
</author>
<author><name sortKey="Gerlach, H" uniqKey="Gerlach H">H Gerlach</name>
</author>
<author><name sortKey="Moreno, R" uniqKey="Moreno R">R Moreno</name>
</author>
<author><name sortKey="Carlet, J" uniqKey="Carlet J">J Carlet</name>
</author>
<author><name sortKey="Le Gall, Jr" uniqKey="Le Gall J">JR Le Gall</name>
</author>
<author><name sortKey="Payen, D" uniqKey="Payen D">D Payen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Volakli, E" uniqKey="Volakli E">E Volakli</name>
</author>
<author><name sortKey="Spies, C" uniqKey="Spies C">C Spies</name>
</author>
<author><name sortKey="Michalopoulos, A" uniqKey="Michalopoulos A">A Michalopoulos</name>
</author>
<author><name sortKey="Groeneveld, Ab" uniqKey="Groeneveld A">AB Groeneveld</name>
</author>
<author><name sortKey="Sakr, Y" uniqKey="Sakr Y">Y Sakr</name>
</author>
<author><name sortKey="Vincent, Jl" uniqKey="Vincent J">JL Vincent</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pieracci, Fm" uniqKey="Pieracci F">FM Pieracci</name>
</author>
<author><name sortKey="Barie, Ps" uniqKey="Barie P">PS Barie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marshall, Jc" uniqKey="Marshall J">JC Marshall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marshall, Jc" uniqKey="Marshall J">JC Marshall</name>
</author>
<author><name sortKey="Al Naqbi, A" uniqKey="Al Naqbi A">A al Naqbi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seifert, H" uniqKey="Seifert H">H Seifert</name>
</author>
<author><name sortKey="Dalhoff, A" uniqKey="Dalhoff A">A Dalhoff</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nicoletti, G" uniqKey="Nicoletti G">G Nicoletti</name>
</author>
<author><name sortKey="Nicolosi, D" uniqKey="Nicolosi D">D Nicolosi</name>
</author>
<author><name sortKey="Rossolini, Gm" uniqKey="Rossolini G">GM Rossolini</name>
</author>
<author><name sortKey="Stefani, S" uniqKey="Stefani S">S Stefani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dupont, H" uniqKey="Dupont H">H Dupont</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seguin, P" uniqKey="Seguin P">P Seguin</name>
</author>
<author><name sortKey="Laviolle, B" uniqKey="Laviolle B">B Laviolle</name>
</author>
<author><name sortKey="Chanavaz, C" uniqKey="Chanavaz C">C Chanavaz</name>
</author>
<author><name sortKey="Donnio, Py" uniqKey="Donnio P">PY Donnio</name>
</author>
<author><name sortKey="Gautier Lerestif, Al" uniqKey="Gautier Lerestif A">AL Gautier-Lerestif</name>
</author>
<author><name sortKey="Campion, Jp" uniqKey="Campion J">JP Campion</name>
</author>
<author><name sortKey="Malledant, Y" uniqKey="Malledant Y">Y Malledant</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cainzos, M" uniqKey="Cainzos M">M Cainzos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barie, Ps" uniqKey="Barie P">PS Barie</name>
</author>
<author><name sortKey="Hydo, Lj" uniqKey="Hydo L">LJ Hydo</name>
</author>
<author><name sortKey="Eachempati, Sr" uniqKey="Eachempati S">SR Eachempati</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bodmann, Kf" uniqKey="Bodmann K">KF Bodmann</name>
</author>
<author><name sortKey="Expertenkommission, I" uniqKey="Expertenkommission I">I Expertenkommission</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dupont, H" uniqKey="Dupont H">H Dupont</name>
</author>
<author><name sortKey="Friggeri, A" uniqKey="Friggeri A">A Friggeri</name>
</author>
<author><name sortKey="Touzeau, J" uniqKey="Touzeau J">J Touzeau</name>
</author>
<author><name sortKey="Airapetian, N" uniqKey="Airapetian N">N Airapetian</name>
</author>
<author><name sortKey="Tinturier, F" uniqKey="Tinturier F">F Tinturier</name>
</author>
<author><name sortKey="Lobjoie, E" uniqKey="Lobjoie E">E Lobjoie</name>
</author>
<author><name sortKey="Lorne, E" uniqKey="Lorne E">E Lorne</name>
</author>
<author><name sortKey="Hijazi, M" uniqKey="Hijazi M">M Hijazi</name>
</author>
<author><name sortKey="Regimbeau, Jm" uniqKey="Regimbeau J">JM Regimbeau</name>
</author>
<author><name sortKey="Mahjoub, Y" uniqKey="Mahjoub Y">Y Mahjoub</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Montravers, P" uniqKey="Montravers P">P Montravers</name>
</author>
<author><name sortKey="Mira, Jp" uniqKey="Mira J">JP Mira</name>
</author>
<author><name sortKey="Gangneux, Jp" uniqKey="Gangneux J">JP Gangneux</name>
</author>
<author><name sortKey="Leroy, O" uniqKey="Leroy O">O Leroy</name>
</author>
<author><name sortKey="Lortholary, O" uniqKey="Lortholary O">O Lortholary</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Montravers, P" uniqKey="Montravers P">P Montravers</name>
</author>
<author><name sortKey="Dupont, H" uniqKey="Dupont H">H Dupont</name>
</author>
<author><name sortKey="Gauzit, R" uniqKey="Gauzit R">R Gauzit</name>
</author>
<author><name sortKey="Veber, B" uniqKey="Veber B">B Veber</name>
</author>
<author><name sortKey="Auboyer, C" uniqKey="Auboyer C">C Auboyer</name>
</author>
<author><name sortKey="Blin, P" uniqKey="Blin P">P Blin</name>
</author>
<author><name sortKey="Hennequin, C" uniqKey="Hennequin C">C Hennequin</name>
</author>
<author><name sortKey="Martin, C" uniqKey="Martin C">C Martin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Solomkin, Js" uniqKey="Solomkin J">JS Solomkin</name>
</author>
<author><name sortKey="Mazuski, Je" uniqKey="Mazuski J">JE Mazuski</name>
</author>
<author><name sortKey="Bradley, Js" uniqKey="Bradley J">JS Bradley</name>
</author>
<author><name sortKey="Rodvold, Ka" uniqKey="Rodvold K">KA Rodvold</name>
</author>
<author><name sortKey="Goldstein, Ej" uniqKey="Goldstein E">EJ Goldstein</name>
</author>
<author><name sortKey="Baron, Ej" uniqKey="Baron E">EJ Baron</name>
</author>
<author><name sortKey="O Eill, Pj" uniqKey="O Eill P">PJ O’Neill</name>
</author>
<author><name sortKey="Chow, Aw" uniqKey="Chow A">AW Chow</name>
</author>
<author><name sortKey="Dellinger, Ep" uniqKey="Dellinger E">EP Dellinger</name>
</author>
<author><name sortKey="Eachempati, Sr" uniqKey="Eachempati S">SR Eachempati</name>
</author>
<author><name sortKey="Gorbach, S" uniqKey="Gorbach S">S Gorbach</name>
</author>
<author><name sortKey="Hilfiker, M" uniqKey="Hilfiker M">M Hilfiker</name>
</author>
<author><name sortKey="May, Ak" uniqKey="May A">AK May</name>
</author>
<author><name sortKey="Nathens, Ab" uniqKey="Nathens A">AB Nathens</name>
</author>
<author><name sortKey="Sawyer, Rg" uniqKey="Sawyer R">RG Sawyer</name>
</author>
<author><name sortKey="Bartlett, Jg" uniqKey="Bartlett J">JG Bartlett</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Calandra, T" uniqKey="Calandra T">T Calandra</name>
</author>
<author><name sortKey="Cohen, J" uniqKey="Cohen J">J Cohen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Waele, Jj" uniqKey="De Waele J">JJ De Waele</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Politano, Ad" uniqKey="Politano A">AD Politano</name>
</author>
<author><name sortKey="Hranjec, T" uniqKey="Hranjec T">T Hranjec</name>
</author>
<author><name sortKey="Rosenberger, Lh" uniqKey="Rosenberger L">LH Rosenberger</name>
</author>
<author><name sortKey="Sawyer, Rg" uniqKey="Sawyer R">RG Sawyer</name>
</author>
<author><name sortKey="Tache Leon, Ca" uniqKey="Tache Leon C">CA Tache Leon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sharma, A" uniqKey="Sharma A">A Sharma</name>
</author>
<author><name sortKey="Mohan, S" uniqKey="Mohan S">S Mohan</name>
</author>
<author><name sortKey="Schorr, C" uniqKey="Schorr C">C Schorr</name>
</author>
<author><name sortKey="Vito, K" uniqKey="Vito K">K Vito</name>
</author>
<author><name sortKey="Milcarek, B" uniqKey="Milcarek B">B Milcarek</name>
</author>
<author><name sortKey="Hunter, K" uniqKey="Hunter K">K Hunter</name>
</author>
<author><name sortKey="Zanotti, S" uniqKey="Zanotti S">S Zanotti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Montravers, P" uniqKey="Montravers P">P Montravers</name>
</author>
<author><name sortKey="Lepape, A" uniqKey="Lepape A">A Lepape</name>
</author>
<author><name sortKey="Dubreuil, L" uniqKey="Dubreuil L">L Dubreuil</name>
</author>
<author><name sortKey="Gauzit, R" uniqKey="Gauzit R">R Gauzit</name>
</author>
<author><name sortKey="Pean, Y" uniqKey="Pean Y">Y Pean</name>
</author>
<author><name sortKey="Benchimol, D" uniqKey="Benchimol D">D Benchimol</name>
</author>
<author><name sortKey="Dupont, H" uniqKey="Dupont H">H Dupont</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carneiro, Ha" uniqKey="Carneiro H">HA Carneiro</name>
</author>
<author><name sortKey="Mavrakis, A" uniqKey="Mavrakis A">A Mavrakis</name>
</author>
<author><name sortKey="Mylonakis, E" uniqKey="Mylonakis E">E Mylonakis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sandven, P" uniqKey="Sandven P">P Sandven</name>
</author>
<author><name sortKey="Qvist, H" uniqKey="Qvist H">H Qvist</name>
</author>
<author><name sortKey="Skovlund, E" uniqKey="Skovlund E">E Skovlund</name>
</author>
<author><name sortKey="Giercksky, Ke" uniqKey="Giercksky K">KE Giercksky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dupont, H" uniqKey="Dupont H">H Dupont</name>
</author>
<author><name sortKey="Bourichon, A" uniqKey="Bourichon A">A Bourichon</name>
</author>
<author><name sortKey="Paugam Burtz, C" uniqKey="Paugam Burtz C">C Paugam-Burtz</name>
</author>
<author><name sortKey="Mantz, J" uniqKey="Mantz J">J Mantz</name>
</author>
<author><name sortKey="Desmonts, Jm" uniqKey="Desmonts J">JM Desmonts</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Andes, Dr" uniqKey="Andes D">DR Andes</name>
</author>
<author><name sortKey="Safdar, N" uniqKey="Safdar N">N Safdar</name>
</author>
<author><name sortKey="Baddley, Jw" uniqKey="Baddley J">JW Baddley</name>
</author>
<author><name sortKey="Playford, G" uniqKey="Playford G">G Playford</name>
</author>
<author><name sortKey="Reboli, Ac" uniqKey="Reboli A">AC Reboli</name>
</author>
<author><name sortKey="Rex, Jh" uniqKey="Rex J">JH Rex</name>
</author>
<author><name sortKey="Sobel, Jd" uniqKey="Sobel J">JD Sobel</name>
</author>
<author><name sortKey="Pappas, Pg" uniqKey="Pappas P">PG Pappas</name>
</author>
<author><name sortKey="Kullberg, Bj" uniqKey="Kullberg B">BJ Kullberg</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Infect Dis</journal-id>
<journal-id journal-id-type="iso-abbrev">BMC Infect. Dis</journal-id>
<journal-title-group><journal-title>BMC Infectious Diseases</journal-title>
</journal-title-group>
<issn pub-type="epub">1471-2334</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25074742</article-id>
<article-id pub-id-type="pmc">4122779</article-id>
<article-id pub-id-type="publisher-id">3717</article-id>
<article-id pub-id-type="doi">10.1186/1471-2334-14-420</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Abdominal infections in the intensive care unit: characteristics, treatment and determinants of outcome</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>De Waele</surname>
<given-names>Jan</given-names>
</name>
<address><email>Jan.DeWaele@UGent.be</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lipman</surname>
<given-names>Jeffrey</given-names>
</name>
<address><email>j.lipman@uq.edu.au</email>
</address>
<xref ref-type="aff" rid="Aff2"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sakr</surname>
<given-names>Yasser</given-names>
</name>
<address><email>Yasser.Sakr@med.uni-jena.de</email>
</address>
<xref ref-type="aff" rid="Aff3"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Marshall</surname>
<given-names>John C</given-names>
</name>
<address><email>marshallj@smh.ca</email>
</address>
<xref ref-type="aff" rid="Aff4"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vanhems</surname>
<given-names>Philippe</given-names>
</name>
<address><email>philippe.vanhems@chu-lyon.fr</email>
</address>
<xref ref-type="aff" rid="Aff5"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Barrera Groba</surname>
<given-names>Casiano</given-names>
</name>
<address><email>cbgroba@nhs.net</email>
</address>
<xref ref-type="aff" rid="Aff6"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Leone</surname>
<given-names>Marc</given-names>
</name>
<address><email>Marc.LEONE@ap-hm.fr</email>
</address>
<xref ref-type="aff" rid="Aff7"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vincent</surname>
<given-names>Jean-Louis</given-names>
</name>
<address><email>jlvincen@ulb.ac.be</email>
</address>
<xref ref-type="aff" rid="Aff8"></xref>
</contrib>
<contrib contrib-type="author"><collab>for the EPIC II Investigators</collab>
</contrib>
<aff id="Aff1"><label></label>
Department of Critical Care Medicine, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium</aff>
<aff id="Aff2"><label></label>
Department of Intensive Care Medicine, Royal Brisbane and Women’s Hospital, The University of Queensland, Butterfield St, Herston, QLD 4029 Australia</aff>
<aff id="Aff3"><label></label>
Department of Anesthesiology and Intensive Care, Friedrich-Schiller-University, Bachstrasse 18, Jena, D-07743 Germany</aff>
<aff id="Aff4"><label></label>
Department of Surgery, Interdepartmental Division of Critical Care Medicine, University of Toronto, St. Michael's Hospital, 4th Floor Bond Wing, Room 4-007, 30 Bond Street, Toronto, Ontario M5B 1 W8 Canada</aff>
<aff id="Aff5"><label></label>
Pôle Santé, Recherche, Risques et Vigilances, Groupement Hospitalier Edouard Herriot, Service d’Hygiène, Epidémiologie et Prévention, Université Lyon 1, Batiment 1, 5 place d'Arsonval, 69437 Lyon cedex 03, France</aff>
<aff id="Aff6"><label></label>
Department of Intensive Care, Brighton and Sussex University Hospitals NHS Trust, Royal Sussex County Hospital, Eastern Road, East Sussex, Brighton BN2 5BE UK</aff>
<aff id="Aff7"><label></label>
Department of Intensive Care and Anesthesiology, Hôpital Nord, AP-HM Unité de Recherche en Maladies Infectieuses et Transmissibles (URMITE), Aix-Marseille University, Chemin des Bourrely, 13015 Marseille, France</aff>
<aff id="Aff8"><label></label>
Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, route de Lennik 808, 1070 Brussels, Belgium</aff>
</contrib-group>
<pub-date pub-type="epub"><day>29</day>
<month>7</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>29</day>
<month>7</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="collection"><year>2014</year>
</pub-date>
<volume>14</volume>
<elocation-id>420</elocation-id>
<history><date date-type="received"><day>10</day>
<month>4</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>18</day>
<month>6</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>© De Waele et al.; licensee BioMed Central Ltd. 2014</copyright-statement>
<license license-type="open-access"><license-p>This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0">http://creativecommons.org/licenses/by/4.0</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<abstract id="Abs1"><sec><title>Background</title>
<p>Abdominal infections are frequent causes of sepsis and septic shock in the intensive care unit (ICU) and are associated with adverse outcomes. We analyzed the characteristics, treatments and outcome of ICU patients with abdominal infections using data extracted from a one-day point prevalence study, the Extended Prevalence of Infection in the ICU (EPIC) II.</p>
</sec>
<sec><title>Methods</title>
<p>EPIC II included 13,796 adult patients from 1,265 ICUs in 75 countries. Infection was defined using the International Sepsis Forum criteria. Microbiological analyses were performed locally. Participating ICUs provided patient follow-up until hospital discharge or for 60 days.</p>
</sec>
<sec><title>Results</title>
<p>Of the 7,087 infected patients, 1,392 (19.6%) had an abdominal infection on the study day (60% male, mean age 62 ± 16 years, SAPS II score 39 ± 16, SOFA score 7.6 ± 4.6). Microbiological cultures were positive in 931 (67%) patients, most commonly Gram-negative bacteria (48.0%). Antibiotics were administered to 1366 (98.1%) patients. Patients who had been in the ICU for ≤2 days prior to the study day had more <italic>Escherichia coli</italic>
, methicillin-sensitive <italic>Staphylococcus aureus</italic>
and anaerobic isolates, and fewer enterococci than patients who had been in the ICU longer<italic>.</italic>
ICU and hospital mortality rates were 29.4% and 36.3%, respectively. ICU mortality was higher in patients with abdominal infections than in those with other infections (29.4% vs. 24.4%, p < 0.001). In multivariable analysis, hematological malignancy, mechanical ventilation, cirrhosis, need for renal replacement therapy and SAPS II score were independently associated with increased mortality.</p>
</sec>
<sec><title>Conclusions</title>
<p>The characteristics, microbiology and antibiotic treatment of abdominal infections in critically ill patients are diverse. Mortality in patients with isolated abdominal infections was higher than in those who had other infections.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/1471-2334-14-420) contains supplementary material, which is available to authorized users.</p>
</sec>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Abdominal infection</kwd>
<kwd>Abscess</kwd>
<kwd>Peritonitis</kwd>
<kwd>Severe sepsis</kwd>
<kwd>Critical care</kwd>
<kwd>Antibiotic therapy</kwd>
<kwd>Microbiology</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2014</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>
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