Judging quality of current septic shock definitions and criteria
Identifieur interne : 000951 ( Pmc/Curation ); précédent : 000950; suivant : 000952Judging quality of current septic shock definitions and criteria
Auteurs : Manu Shankar-Hari ; Guido Bertolini [Italie] ; Frank M. Brunkhorst [Allemagne] ; Rinaldo Bellomo ; Djillali Annane [France] ; Clifford S. Deutschman [États-Unis] ; Mervyn Singer [Royaume-Uni]Source :
- Critical Care [ 1364-8535 ] ; 2015.
Abstract
Septic shock definitions are being revisited. We assess the
Url:
DOI: 10.1186/s13054-015-1164-6
PubMed: 26702879
PubMed Central: 4699344
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Manu Shankar-Hari<affiliation><nlm:aff id="Aff1">Department of Intensive Care Medicine, 1st Floor, East Wing, St Thomas’ Hospital, Guy’s and St Thomas’ NHS Foundation Trust, Westminster Bridge Road, London, SE1 7EH UK</nlm:aff><wicri:noCountry code="subfield">SE1 7EH UK</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2">Division of Asthma, Allergy and Lung Biology, King’s College London, ᅟ, SE1 9RT UK</nlm:aff><wicri:noCountry code="subfield">SE1 9RT UK</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2">Division of Asthma, Allergy and Lung Biology, King’s College London, ᅟ, SE1 9RT UK</nlm:aff><wicri:noCountry code="subfield">SE1 9RT UK</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff5">Department of Intensive Care and Medicine, Austin Health, Heidelberg, Melbourne, VIC 3084 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3084 Australia</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Judging quality of current septic shock definitions and criteria</title><author><name sortKey="Shankar Hari, Manu" sort="Shankar Hari, Manu" uniqKey="Shankar Hari M" first="Manu" last="Shankar-Hari">Manu Shankar-Hari</name><affiliation><nlm:aff id="Aff1">Department of Intensive Care Medicine, 1st Floor, East Wing, St Thomas’ Hospital, Guy’s and St Thomas’ NHS Foundation Trust, Westminster Bridge Road, London, SE1 7EH UK</nlm:aff><wicri:noCountry code="subfield">SE1 7EH UK</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2">Division of Asthma, Allergy and Lung Biology, King’s College London, ᅟ, SE1 9RT UK</nlm:aff><wicri:noCountry code="subfield">SE1 9RT UK</wicri:noCountry></affiliation></author><author><name sortKey="Bertolini, Guido" sort="Bertolini, Guido" uniqKey="Bertolini G" first="Guido" last="Bertolini">Guido Bertolini</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Laboratory of Clinical Epidemiology and GiViTI Coordinating Centre, IRCCS-Istituto di Ricerche Farmacologiche “Mario Negri”, Villa Camozzi 24020 Ranica (Bergamo), Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratory of Clinical Epidemiology and GiViTI Coordinating Centre, IRCCS-Istituto di Ricerche Farmacologiche “Mario Negri”, Villa Camozzi 24020 Ranica (Bergamo)</wicri:regionArea></affiliation></author><author><name sortKey="Brunkhorst, Frank M" sort="Brunkhorst, Frank M" uniqKey="Brunkhorst F" first="Frank M." last="Brunkhorst">Frank M. Brunkhorst</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Paul-Martini-Research Group for Clinical Sepsis Research, Center for Clinical Studies, Jena University Hospital, Salvador-Allende-Platz 29, Jena, 07737 Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Paul-Martini-Research Group for Clinical Sepsis Research, Center for Clinical Studies, Jena University Hospital, Salvador-Allende-Platz 29, Jena</wicri:regionArea></affiliation></author><author><name sortKey="Bellomo, Rinaldo" sort="Bellomo, Rinaldo" uniqKey="Bellomo R" first="Rinaldo" last="Bellomo">Rinaldo Bellomo</name><affiliation><nlm:aff id="Aff5">Department of Intensive Care and Medicine, Austin Health, Heidelberg, Melbourne, VIC 3084 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3084 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Annane, Djillali" sort="Annane, Djillali" uniqKey="Annane D" first="Djillali" last="Annane">Djillali Annane</name><affiliation wicri:level="1"><nlm:aff id="Aff6">Department of Intensive Care Medicine, Hôpital Raymond Poincaré (AP-HP), Laboratory of Cell Death, Inflammation & Infection, UMR1173 University of Versailles SQY & INSERM, 92380 Garches, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Intensive Care Medicine, Hôpital Raymond Poincaré (AP-HP), Laboratory of Cell Death, Inflammation & Infection, UMR1173 University of Versailles SQY & INSERM, 92380 Garches</wicri:regionArea></affiliation></author><author><name sortKey="Deutschman, Clifford S" sort="Deutschman, Clifford S" uniqKey="Deutschman C" first="Clifford S." last="Deutschman">Clifford S. Deutschman</name><affiliation wicri:level="2"><nlm:aff id="Aff7">Departments of Pediatrics and Molecular Medicine, Hofstra-North Shore-Long Island Jewish-Hofstra School of Medicine, New Hyde Park, NY 11040 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Departments of Pediatrics and Molecular Medicine, Hofstra-North Shore-Long Island Jewish-Hofstra School of Medicine, New Hyde Park</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff8">Feinstein Institute for Medical Research, Manhasset, NY 11030 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Feinstein Institute for Medical Research, Manhasset</wicri:cityArea></affiliation></author><author><name sortKey="Singer, Mervyn" sort="Singer, Mervyn" uniqKey="Singer M" first="Mervyn" last="Singer">Mervyn Singer</name><affiliation wicri:level="4"><nlm:aff id="Aff9">Bloomsbury Institute of Intensive Care Medicine, University College London, London, WC1E 6BT UK</nlm:aff><orgName type="university">University College de Londres</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26702879</idno><idno type="pmc">4699344</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699344</idno><idno type="RBID">PMC:4699344</idno><idno type="doi">10.1186/s13054-015-1164-6</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000973</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000973</idno><idno type="wicri:Area/Pmc/Curation">000951</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000951</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Judging quality of current septic shock definitions and criteria</title><author><name sortKey="Shankar Hari, Manu" sort="Shankar Hari, Manu" uniqKey="Shankar Hari M" first="Manu" last="Shankar-Hari">Manu Shankar-Hari</name><affiliation><nlm:aff id="Aff1">Department of Intensive Care Medicine, 1st Floor, East Wing, St Thomas’ Hospital, Guy’s and St Thomas’ NHS Foundation Trust, Westminster Bridge Road, London, SE1 7EH UK</nlm:aff><wicri:noCountry code="subfield">SE1 7EH UK</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2">Division of Asthma, Allergy and Lung Biology, King’s College London, ᅟ, SE1 9RT UK</nlm:aff><wicri:noCountry code="subfield">SE1 9RT UK</wicri:noCountry></affiliation></author><author><name sortKey="Bertolini, Guido" sort="Bertolini, Guido" uniqKey="Bertolini G" first="Guido" last="Bertolini">Guido Bertolini</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Laboratory of Clinical Epidemiology and GiViTI Coordinating Centre, IRCCS-Istituto di Ricerche Farmacologiche “Mario Negri”, Villa Camozzi 24020 Ranica (Bergamo), Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratory of Clinical Epidemiology and GiViTI Coordinating Centre, IRCCS-Istituto di Ricerche Farmacologiche “Mario Negri”, Villa Camozzi 24020 Ranica (Bergamo)</wicri:regionArea></affiliation></author><author><name sortKey="Brunkhorst, Frank M" sort="Brunkhorst, Frank M" uniqKey="Brunkhorst F" first="Frank M." last="Brunkhorst">Frank M. Brunkhorst</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Paul-Martini-Research Group for Clinical Sepsis Research, Center for Clinical Studies, Jena University Hospital, Salvador-Allende-Platz 29, Jena, 07737 Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Paul-Martini-Research Group for Clinical Sepsis Research, Center for Clinical Studies, Jena University Hospital, Salvador-Allende-Platz 29, Jena</wicri:regionArea></affiliation></author><author><name sortKey="Bellomo, Rinaldo" sort="Bellomo, Rinaldo" uniqKey="Bellomo R" first="Rinaldo" last="Bellomo">Rinaldo Bellomo</name><affiliation><nlm:aff id="Aff5">Department of Intensive Care and Medicine, Austin Health, Heidelberg, Melbourne, VIC 3084 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3084 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Annane, Djillali" sort="Annane, Djillali" uniqKey="Annane D" first="Djillali" last="Annane">Djillali Annane</name><affiliation wicri:level="1"><nlm:aff id="Aff6">Department of Intensive Care Medicine, Hôpital Raymond Poincaré (AP-HP), Laboratory of Cell Death, Inflammation & Infection, UMR1173 University of Versailles SQY & INSERM, 92380 Garches, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Intensive Care Medicine, Hôpital Raymond Poincaré (AP-HP), Laboratory of Cell Death, Inflammation & Infection, UMR1173 University of Versailles SQY & INSERM, 92380 Garches</wicri:regionArea></affiliation></author><author><name sortKey="Deutschman, Clifford S" sort="Deutschman, Clifford S" uniqKey="Deutschman C" first="Clifford S." last="Deutschman">Clifford S. Deutschman</name><affiliation wicri:level="2"><nlm:aff id="Aff7">Departments of Pediatrics and Molecular Medicine, Hofstra-North Shore-Long Island Jewish-Hofstra School of Medicine, New Hyde Park, NY 11040 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Departments of Pediatrics and Molecular Medicine, Hofstra-North Shore-Long Island Jewish-Hofstra School of Medicine, New Hyde Park</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff8">Feinstein Institute for Medical Research, Manhasset, NY 11030 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Feinstein Institute for Medical Research, Manhasset</wicri:cityArea></affiliation></author><author><name sortKey="Singer, Mervyn" sort="Singer, Mervyn" uniqKey="Singer M" first="Mervyn" last="Singer">Mervyn Singer</name><affiliation wicri:level="4"><nlm:aff id="Aff9">Bloomsbury Institute of Intensive Care Medicine, University College London, London, WC1E 6BT UK</nlm:aff><orgName type="university">University College de Londres</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j">Critical Care</title><idno type="ISSN">1364-8535</idno><idno type="eISSN">1466-609X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Septic shock definitions are being revisited. We assess the <italic>feasibility</italic>, <italic>reliability</italic>, and <italic>validity</italic> characteristics of the current definitions and criteria of septic shock. Septic shock is conceptualised as cardiovascular dysfunction, tissue perfusion and cellular abnormalities caused by infection. Currently, for feasibility, septic shock is identified at the bedside by using <italic>either</italic> hypotension <italic>or</italic> a proxy for tissue perfusion/cellular abnormalities (e.g., hyperlactatemia). We propose that <italic>concurrent</italic> presence of cardiovascular dysfunction <italic>and</italic> perfusion/cellular abnormalities could improve validity of septic shock diagnosis, as we are more likely to identify a patient population with all elements of the illness concept. This epidemiological refinement should not affect clinical care and may aid study design to identify illness-specific biomarkers and interventions.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Shankar Hari, M" uniqKey="Shankar Hari M">M Shankar-Hari</name></author><author><name sortKey="Deutschman, Cs" uniqKey="Deutschman C">CS Deutschman</name></author><author><name sortKey="Singer, M" uniqKey="Singer M">M Singer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rubenfeld, Gd" uniqKey="Rubenfeld G">GD Rubenfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiao, W" uniqKey="Xiao W">W Xiao</name></author><author><name sortKey="Mindrinos, Mn" uniqKey="Mindrinos M">MN Mindrinos</name></author><author><name sortKey="Seok, J" uniqKey="Seok J">J Seok</name></author><author><name sortKey="Cuschieri, J" uniqKey="Cuschieri J">J 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Crit Care</journal-id><journal-title-group><journal-title>Critical Care</journal-title></journal-title-group><issn pub-type="ppub">1364-8535</issn><issn pub-type="epub">1466-609X</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26702879</article-id><article-id pub-id-type="pmc">4699344</article-id><article-id pub-id-type="publisher-id">1164</article-id><article-id pub-id-type="doi">10.1186/s13054-015-1164-6</article-id><article-categories><subj-group subj-group-type="heading"><subject>Viewpoint</subject></subj-group></article-categories><title-group><article-title>Judging quality of current septic shock definitions and criteria</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Shankar-Hari</surname><given-names>Manu</given-names></name><address><email>manu.shankar-hari@kcl.ac.uk</email></address><xref ref-type="aff" rid="Aff1"></xref><xref ref-type="aff" rid="Aff2"></xref></contrib><contrib contrib-type="author"><name><surname>Bertolini</surname><given-names>Guido</given-names></name><xref ref-type="aff" rid="Aff3"></xref></contrib><contrib contrib-type="author"><name><surname>Brunkhorst</surname><given-names>Frank M.</given-names></name><xref ref-type="aff" rid="Aff4"></xref></contrib><contrib contrib-type="author"><name><surname>Bellomo</surname><given-names>Rinaldo</given-names></name><xref ref-type="aff" rid="Aff5"></xref></contrib><contrib contrib-type="author"><name><surname>Annane</surname><given-names>Djillali</given-names></name><xref ref-type="aff" rid="Aff6"></xref></contrib><contrib contrib-type="author"><name><surname>Deutschman</surname><given-names>Clifford S.</given-names></name><xref ref-type="aff" rid="Aff7"></xref><xref ref-type="aff" rid="Aff8"></xref></contrib><contrib contrib-type="author"><name><surname>Singer</surname><given-names>Mervyn</given-names></name><xref ref-type="aff" rid="Aff9"></xref></contrib><aff id="Aff1"><label></label>Department of Intensive Care Medicine, 1st Floor, East Wing, St Thomas’ Hospital, Guy’s and St Thomas’ NHS Foundation Trust, Westminster Bridge Road, London, SE1 7EH UK</aff><aff id="Aff2"><label></label>Division of Asthma, Allergy and Lung Biology, King’s College London, ᅟ, SE1 9RT UK</aff><aff id="Aff3"><label></label>Laboratory of Clinical Epidemiology and GiViTI Coordinating Centre, IRCCS-Istituto di Ricerche Farmacologiche “Mario Negri”, Villa Camozzi 24020 Ranica (Bergamo), Italy</aff><aff id="Aff4"><label></label>Paul-Martini-Research Group for Clinical Sepsis Research, Center for Clinical Studies, Jena University Hospital, Salvador-Allende-Platz 29, Jena, 07737 Germany</aff><aff id="Aff5"><label></label>Department of Intensive Care and Medicine, Austin Health, Heidelberg, Melbourne, VIC 3084 Australia</aff><aff id="Aff6"><label></label>Department of Intensive Care Medicine, Hôpital Raymond Poincaré (AP-HP), Laboratory of Cell Death, Inflammation & Infection, UMR1173 University of Versailles SQY & INSERM, 92380 Garches, France</aff><aff id="Aff7"><label></label>Departments of Pediatrics and Molecular Medicine, Hofstra-North Shore-Long Island Jewish-Hofstra School of Medicine, New Hyde Park, NY 11040 USA</aff><aff id="Aff8"><label></label>Feinstein Institute for Medical Research, Manhasset, NY 11030 USA</aff><aff id="Aff9"><label></label>Bloomsbury Institute of Intensive Care Medicine, University College London, London, WC1E 6BT UK</aff></contrib-group><pub-date pub-type="epub"><day>25</day><month>12</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>25</day><month>12</month><year>2015</year></pub-date><pub-date pub-type="ppub"><year>2015</year></pub-date><volume>19</volume><elocation-id>445</elocation-id><permissions><copyright-statement>© Shankar-Hari et al. 2015</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><p>Septic shock definitions are being revisited. We assess the <italic>feasibility</italic>, <italic>reliability</italic>, and <italic>validity</italic> characteristics of the current definitions and criteria of septic shock. Septic shock is conceptualised as cardiovascular dysfunction, tissue perfusion and cellular abnormalities caused by infection. Currently, for feasibility, septic shock is identified at the bedside by using <italic>either</italic> hypotension <italic>or</italic> a proxy for tissue perfusion/cellular abnormalities (e.g., hyperlactatemia). We propose that <italic>concurrent</italic> presence of cardiovascular dysfunction <italic>and</italic> perfusion/cellular abnormalities could improve validity of septic shock diagnosis, as we are more likely to identify a patient population with all elements of the illness concept. This epidemiological refinement should not affect clinical care and may aid study design to identify illness-specific biomarkers and interventions.</p></abstract><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2015</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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