Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications
Identifieur interne : 000895 ( Pmc/Curation ); précédent : 000894; suivant : 000896Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications
Auteurs : G. Todd Milne [États-Unis] ; Peter Sandner [Allemagne] ; Kathleen A. Lincoln [États-Unis] ; Paul C. Harrison [États-Unis] ; Hongxing Chen [États-Unis] ; Hong Wang [États-Unis] ; Holly Clifford [États-Unis] ; Hu Sheng Qian [États-Unis] ; Diane Wong [États-Unis] ; Chris Sarko [États-Unis] ; Ryan Fryer [États-Unis] ; Jeremy Richman [États-Unis] ; Glenn A. Reinhart [États-Unis] ; Carine M. Boustany [États-Unis] ; Steven S. Pullen [États-Unis] ; Henriette Andresen [Norvège] ; Lise Román Moltzau [Norvège] ; Alessandro Cataliotti [Norvège] ; Finn Olav Levy [Norvège] ; Robert Lukowski [Allemagne] ; Sandra Frankenreiter [Allemagne] ; Andreas Friebe [Allemagne] ; Timothy Calamaras [États-Unis] ; Robert Baumgartner [États-Unis] ; Angela Mclaughlin [États-Unis] ; Mark Aronovitz [États-Unis] ; Wendy Baur [États-Unis] ; Guang-Rong Wang [États-Unis] ; Navin Kapur [États-Unis] ; Richard Karas [États-Unis] ; Robert Blanton [États-Unis] ; Stefan Hell [Allemagne] ; Scott A. Waldman [États-Unis] ; Jieru E. Lin [États-Unis] ; Francheska Colon-Gonzalez [États-Unis] ; Gilbert W. Kim [États-Unis] ; Erik S. Blomain [États-Unis] ; Dante Merlino [États-Unis] ; Adam Snook [États-Unis] ; Jeanette Erdmann [Allemagne] ; Jana Wobst [Allemagne] ; Thorsten Kessler [Allemagne] ; Heribert Schunkert [Allemagne] ; Ulrich Walter [Allemagne] ; Oliver Pagel [Allemagne] ; Elena Walter [Allemagne] ; Stepan Gambaryan [Allemagne, Russie] ; Albert Smolenski [Irlande (pays)] ; Kerstin Jurk [Allemagne] ; Rene Zahedi [Allemagne] ; James R. Klinger [États-Unis] ; Raymond L. Benza [États-Unis] ; Paul A. Corris [Royaume-Uni] ; David Langleben ; Robert Naeije [Belgique] ; Gérald Simonneau [France] ; Christian Meier [Allemagne] ; Pablo Colorado [Espagne] ; Mi Kyung Chang [Allemagne] ; Dennis Busse [Allemagne] ; Marius M. Hoeper [Allemagne] ; Jaime L. Masferrer [États-Unis] ; Sarah Jacobson [États-Unis] ; Guang Liu [États-Unis] ; Renee Sarno [États-Unis] ; Sylvie Bernier [États-Unis] ; Ping Zhang ; G. Todd Milne [États-Unis] ; Roger Flores-Costa [Espagne] ; Mark Currie [États-Unis] ; Katherine Hall [États-Unis] ; Dorit Möhrle [Allemagne] ; Katrin Reimann [Allemagne] ; Steffen Wolter [Allemagne] ; Markus Wolters [Allemagne] ; Evanthia Mergia [Allemagne] ; Nicole Eichert [Allemagne] ; Hyun-Soon Geisler [Allemagne] ; Peter Ruth [Allemagne] ; Andreas Friebe [Allemagne] ; Robert Feil [Allemagne] ; Ulrike Zimmermann [Allemagne] ; Doris Koesling [Allemagne] ; Marlies Knipper [Allemagne] ; Lukas Rüttiger [Allemagne] ; Yasutake Tanaka [Japon] ; Atsuko Okamoto [Japon] ; Takashi Nojiri [Japon] ; Motofumi Kumazoe [Japon] ; Takeshi Tokudome [Japon] ; Koichi Miura [Japon] ; Jun Hino [Japon] ; Hiroshi Hosoda [Japon] ; Mikiya Miyazato [Japon] ; Kenji Kangawa [Japon] ; Vikas Kapil [Royaume-Uni] ; Amrita Ahluwalia [Royaume-Uni] ; Nazareno Paolocci [Italie] ; Philip Eaton [Royaume-Uni] ; James C. Campbell [États-Unis] ; Philipp Henning ; Eugen Franz ; Banumathi Sankaran [États-Unis] ; Friedrich W. Herberg [États-Unis] ; Choel Kim [États-Unis] ; M. Wittwer [Allemagne] ; Q. Luo [Allemagne] ; V. Kaila [Allemagne] ; S. A. Dames [Allemagne] ; Andrew Tobin [Royaume-Uni] ; Mahmood Alam [Royaume-Uni] ; Olena Rudyk ; Susanne Krasemann [Allemagne] ; Kristin Hartmann [Allemagne] ; Oleksandra Prysyazhna ; Min Zhang ; Lan Zhao ; Astrid Weiss [Allemagne] ; Ralph Schermuly [Allemagne] ; Philip Eaton ; Amie J. Moyes [Royaume-Uni] ; Sandy M. Chu [Royaume-Uni] ; Reshma S. Baliga [Royaume-Uni] ; Adrian J. Hobbs [Royaume-Uni] ; Stylianos Michalakis [Allemagne] ; Regine Mühlfriedel [Allemagne] ; Christian Schön [Allemagne] ; Dominik M. Fischer [Allemagne] ; Barbara Wilhelm [Allemagne] ; Ditta Zobor [Allemagne] ; Susanne Kohl [Allemagne] ; Tobias Peters [Allemagne] ; Eberhart Zrenner [Allemagne] ; Karl Ulrich Bartz-Schmidt [Allemagne] ; Marius Ueffing [Allemagne] ; Bernd Wissinger [Allemagne] ; Mathias Seeliger [Allemagne] ; Martin Biel [Allemagne] ; Mark J. Ranek [États-Unis] ; Kristen M. Kokkonen [États-Unis] ; Dong I. Lee [États-Unis] ; Ronald J. Holewinski [États-Unis] ; Vineet Agrawal [États-Unis] ; Cornelia Virus [États-Unis] ; Donté A. Stevens [États-Unis] ; Masayuki Sasaki [États-Unis] ; Huaqun Zhang [États-Unis] ; Mathew M. Mannion [États-Unis] ; Peter P. Rainer [États-Unis] ; Richard C. Page [États-Unis] ; Jonathan C. Schisler [États-Unis] ; Jennifer E. Van Eyk [États-Unis] ; Monte S. Willis [États-Unis] ; David A. Kass [États-Unis] ; Manuela Zaccolo [Royaume-Uni] ; Michael Russwurm [Allemagne] ; Jan Giesen [Allemagne] ; Corina Russwurm [Allemagne] ; Ernst-Martin Füchtbauer [Danemark] ; Doris Koesling [Allemagne] ; Nadja I. Bork [Allemagne] ; Viacheslav O. Nikolaev [Allemagne] ; Luis Agull ; Martin Floor ; Jordi Villà-Freixa ; Ornella Manfra [Norvège] ; Gaia Calamera [Norvège] ; Nicoletta C. Surdo [Royaume-Uni] ; Silja Meier [Norvège] ; Alexander Froese [Allemagne] ; Viacheslav O. Nikolaev [Allemagne] ; Manuela Zaccolo [Royaume-Uni] ; Finn Olav Levy [Norvège] ; Kjetil Wessel Andressen [Norvège] ; Annemarie Aue [Allemagne] ; Fabian Schwiering [Allemagne] ; Dieter Groneberg [Allemagne] ; Andreas Friebe [Allemagne] ; Gzona Bajraktari [Allemagne] ; Jürgen Burhenne [Allemagne] ; Walter E. Haefeli [Allemagne] ; Johanna Weiss [Allemagne] ; Katharina Beck [Allemagne] ; Barbara Voussen [Allemagne] ; Alexander Vincent [Canada] ; Sean P. Parsons [Canada] ; Jan D. Huizinga [Canada] ; Andreas Friebe [Allemagne] ; Fabiola Zakia M Nica [États-Unis] ; Edward Seto [États-Unis] ; Ferid Murad [États-Unis] ; Ka Bian [États-Unis] ; Joseph R. Burgoyne ; Oleksandra Prysyazhna ; Daniel Richards ; Philip Eaton ; Gaia Calamera [Norvège] ; Marianne Bj Rnerem [Norvège] ; Andrea Hembre Ulsund [Norvège] ; Jeong Joo Kim ; Choel Kim ; Finn Olav Levy [Norvège] ; Kjetil Wessel Andressen [Norvège] ; Sonia Donzelli [Allemagne] ; Mara Goetz [Allemagne] ; Kjestine Schmidt [Allemagne] ; Markus Wolters [Allemagne] ; Konstantina Stathopoulou [Allemagne] ; Oleksandra Prysyazhna [Royaume-Uni] ; Jenna Scotcher [Royaume-Uni] ; Christian Dees [Allemagne] ; Hariharan Subramanian [Allemagne] ; Elke Butt [Allemagne] ; Alisa Kamynina [Royaume-Uni] ; S. Bruce King [États-Unis] ; Viacheslav O. Nikolaev [Allemagne] ; Cor De Witt [Allemagne] ; Lars I. Leichert [Allemagne] ; Robert Feil [Allemagne] ; Philip Eaton [Royaume-Uni] ; Friederike Cuello [Allemagne] ; Hyazinth Dobrowinski [Allemagne] ; Moritz Lehners [Allemagne] ; Michael Paolillo Hannes Schmidt [Allemagne] ; Robert Feil [Allemagne] ; Susanne Feil [Allemagne] ; Lai Wen [Allemagne] ; Markus Wolters [Allemagne] ; Martin Thunemann [Allemagne] ; Kjestine Schmidt [Allemagne] ; Marcus Olbrich [Allemagne] ; Harald Langer [Allemagne] ; Meinrad Gawaz [Allemagne] ; Andreas Friebe [Allemagne] ; Cor De Wit [Allemagne] ; Robert Feil [Allemagne] ; Eugen Franz [Allemagne] ; Jeong Joo Kim [Allemagne] ; Daniela Bertinetti [Allemagne] ; Choel Kim ; Friedrich W. Herberg [Allemagne] ; Hossein-Ardeschir Ghofrani [Allemagne] ; Friedrich Grimminger [Allemagne] ; Ekkehard Grünig [Allemagne] ; Yigao Huang ; Pavel Jansa [République tchèque] ; Zhi Cheng Jing [République populaire de Chine] ; David Kilpatrick [Australie] ; David Langleben ; Stephan Rosenkranz [Allemagne] ; Flavia Menezes [Brésil] ; Arno Fritsch [Allemagne] ; Sylvia Nikkho [Allemagne] ; Reiner Frey [Allemagne] ; Marc Humbert [France] ; Dieter Groneberg [Allemagne] ; Annemarie Aue [Allemagne] ; Fabian Schwiering [Allemagne] ; Andreas Friebe [Allemagne] ; Manuela Harloff [Allemagne] ; Joerg Reinders [Allemagne] ; Jens Schlossmann [Allemagne] ; Joon Jung [États-Unis] ; Jessica A. Wales ; Cheng-Yu Chen ; Linda Breci ; Andrzej Weichsel ; Sylvie G. Bernier [États-Unis] ; Robert Solinga [États-Unis] ; James E. Sheppeck [États-Unis] ; Paul A. Renhowe [États-Unis] ; William R. Montfort ; Liying Qin ; Ying-Ju Sung [États-Unis] ; Darren Casteel [États-Unis] ; Choel Kim ; Alexander Kollau [Autriche] ; Andrea Neubauer [Autriche] ; Astrid Schrammel [Autriche] ; Michael Russwurm [Allemagne] ; Doris Koesling [Allemagne] ; Bernd Mayer [Autriche] ; Motofumi Kumazoe [Japon] ; Mika Takai [Japon] ; Chieri Takeuchi [Japon] ; Mai Kadomatsu [Japon] ; Shun Hiroi [Japon] ; Kanako Takamatsu [Japon] ; Takashi Nojiri ; Kenji Kangawa ; Hirofumi Tachibana [Japon] ; Marissa Opelt [Autriche] ; Emrah Eroglu [Autriche] ; Markus Waldeck-Weiermair [Autriche] ; Michael Russwurm [Allemagne] ; Doris Koesling [Allemagne] ; Roland Malli [Autriche] ; Wolfgang F. Graier [Autriche] ; John T. Fassett [Autriche] ; Astrid Schrammel [Autriche] ; Bernd Mayer [Autriche] ; Selene J. Sollie [Norvège] ; Lise Román Moltzau [Norvège] ; Maria Hernandez-Valladares [Norvège] ; Frode Berven [Norvège] ; Finn Olav Levy [Norvège] ; Kjetil W. Andressen [Norvège] ; Takashi Nojiri [Japon] ; Takeshi Tokudome [Japon] ; Motofumi Kumazoe [Japon] ; Miki Arai [Japon] ; Yutaka Suzuki [Japon] ; Koichi Miura [Japon] ; Jun Hino [Japon] ; Hiroshi Hosoda [Japon] ; Mikiya Miyazato [Japon] ; Meinoshin Okumura [Japon] ; Shinpei Kawaoka [Japon] ; Kenji Kangawa [Japon] ; Stefanie Peters [Allemagne] ; Hannes Schmidt [Allemagne] ; B. Selin Kenet [Allemagne] ; Sarah Helena Nies [Allemagne] ; Katharina Frank [Allemagne] ; Lai Wen [Allemagne] ; Fritz G. Rathjen [Allemagne] ; Robert Feil [Allemagne] ; Olga N. Petrova [France] ; Isabelle Lamarre [France] ; Michel Négrerie [France] ; Jerid W. Robinson [États-Unis] ; Jeremy R. Egbert [États-Unis] ; Julia Davydova [États-Unis] ; Laurinda A. Jaffe [États-Unis] ; Lincoln R. Potter [États-Unis] ; Jerid W. Robinson [États-Unis] ; Nicholas Blixt [États-Unis] ; Leia C. Shuhaibar [États-Unis] ; Gordon L. Warren [États-Unis] ; Kim C. Mansky [États-Unis] ; Laurinda A. Jaffe [États-Unis] ; Lincoln R. Potter [États-Unis] ; Simone Romoli [Allemagne] ; Tobias Bauch [Allemagne] ; Karoline Dröbner [Allemagne] ; Frank Eitner [Allemagne] ; Mihály Ruppert [Allemagne, Hongrie] ; Tamás Radovits [Hongrie] ; Sevil Korkmaz-Icöz [Allemagne] ; Shiliang Li [Allemagne] ; Péter Heged S [Allemagne] ; Sivakanan Loganathan [Allemagne] ; Balázs Tamás Németh [Hongrie] ; Attila Oláh [Hongrie] ; Csaba Mátyás [Hongrie] ; Kálmán Benke [Hongrie] ; Béla Merkely [Hongrie] ; Matthias Karck [Allemagne] ; Gábor Szab [Allemagne] ; Ulrike Scheib [Allemagne] ; Matthias Broser [Allemagne] ; Shatanik Mukherjee [Allemagne] ; Katja Stehfest [Allemagne] ; Christine E. Gee [Allemagne] ; Heinz G. Körschen [Allemagne] ; Thomas G. Oertner [Allemagne] ; Peter Hegemann [Allemagne] ; Hannes Schmidt [Allemagne] ; Deborah M. Dickey ; Alexandre Dumoulin [Allemagne] ; Ralf Kühn [Allemagne] ; Laurinda Jaffe ; Lincoln R. Potter ; Fritz G. Rathjen [Allemagne] ; Sophie Schobesberger [Allemagne] ; Peter Wright ; Claire Poulet ; Catherine Mansfield ; Andreas Friebe [Allemagne] ; Sian E. Harding ; Viacheslav O. Nikolaev [Allemagne] ; Julia Gorelik ; Alexander Kollau [Autriche] ; Marissa Opelt [Autriche] ; Gerald Wölkart [Autriche] ; Antonius C. F. Gorren [Autriche] ; Michael Russwurm [Allemagne] ; Doris Koesling [Allemagne] ; Astrid Schrammel [Autriche] ; Bernd Mayer [Autriche] ; Gerburg K. Schwaerzer [États-Unis] ; Darren E. Casteel [États-Unis] ; Nancy D. Dalton [États-Unis] ; Yusu Gu [États-Unis] ; Shunhui Zhuang [États-Unis] ; Dianna M. Milewicz [États-Unis] ; Kirk L. Peterson [États-Unis] ; Renate Pilz [États-Unis] ; Fabian Schwiering [Allemagne] ; Annemarie Aue [Allemagne] ; Dieter Groneberg [Allemagne] ; Andreas Friebe [Allemagne] ; Aikaterini I. Argyriou [Grèce] ; Garyfalia Makrynitsa [Grèce] ; Ioannis I. Alexandropoulos [Grèce] ; Andriana Stamopoulou [Grèce] ; Marina Bantzi [Allemagne] ; Athanassios Giannis [Allemagne] ; Stavros Topouzis [Grèce] ; Andreas Papapetropoulos [Grèce] ; Georgios A. Spyroulias [Grèce] ; Dennis J. Stuehr [États-Unis] ; Arnab Ghosh [États-Unis] ; Yue Dai [États-Unis] ; Saurav Misra [États-Unis] ; Boris Tchernychev [États-Unis] ; Joon Jung [États-Unis] ; Guang Liu [États-Unis] ; Inmaculada Silos-Santiago [États-Unis] ; Gerhard Hannig [États-Unis] ; Vu Thao-Vi Dao [Pays-Bas, Allemagne] ; Martin Deile [Allemagne] ; Pavel I. Nedvetsky [Belgique] ; Andreas Güldner [Allemagne] ; César Ibarra-Alvarado [Mexique] ; Axel Gödecke [Allemagne] ; Harald H. H. W. Schmidt [Pays-Bas] ; Angelos Vachaviolos [Allemagne] ; Andrea Gerling [Allemagne] ; Martin Thunemann [Allemagne] ; Stefan Z. Lutz [Allemagne] ; Hans-Ulrich H Ring [Allemagne] ; Marcel A. Krüger [Allemagne] ; Bernd J. Pichler [Allemagne] ; Michael J. Shipston ; Susanne Feil [Allemagne] ; Robert Feil [Allemagne] ; Sara Vandenwijngaert ; Clara D. Ledsky ; Obiajulu Agha ; Dongjian Hu ; Ibrahim J. Domian ; Emmanuel S. Buys ; Christopher Newton-Cheh ; Donald B. Bloch ; Barbara Voussen [Allemagne] ; Katharina Beck [Allemagne] ; Nadine Mauro [Allemagne] ; Jonas Keppler [Allemagne] ; Andreas Friebe [Allemagne] ; Wilson A. Ferreira [Brésil] ; Hanan Chweih [Brésil] ; Pamela L. Brito [Brésil] ; Camila B. Almeida [Brésil] ; Carla F. F. Penteado [Brésil] ; Sara S. O. Saad [Brésil] ; Fernando F. Costa [Brésil] ; Paul S. Frenette [États-Unis] ; Damian Brockschnieder [Allemagne] ; Johannes-Peter Stasch [Allemagne] ; Peter Sandner [Allemagne] ; Nicola Conran [Brésil] ; Daniel P. Zimmer [États-Unis] ; Jenny Tobin [États-Unis] ; Courtney Shea [États-Unis] ; Renee Sarno [États-Unis] ; Kimberly Long [États-Unis] ; Sarah Jacobson [États-Unis] ; Kim Tang [États-Unis] ; Peter Germano [États-Unis] ; James Wakefield [États-Unis] ; Ali Banijamali [États-Unis] ; G-Yoon Jamie Im [États-Unis] ; James E. Sheppeck [États-Unis] ; Albert T. Profy [États-Unis] ; G. Todd Milne [États-Unis] ; Mark G. Currie [États-Unis] ; Jaime L. Masferrer [États-Unis]Source :
- BMC Pharmacology & Toxicology [ 2050-6511 ] ; 2017.
Url:
DOI: 10.1186/s40360-017-0170-5
PubMed: 29035170
PubMed Central: 5667593
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000899
Links to Exploration step
PMC:5667593Curation
No country items
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5-7-1 Fujishiro-dai, Suita-City, Osaka 565-8565 Japan</nlm:aff>
<wicri:noCountry code="subfield">Osaka 565-8565 Japan</wicri:noCountry>
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5-7-1 Fujishiro-dai, Suita-City, Osaka 565-8565 Japan</nlm:aff>
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5-7-1 Fujishiro-dai, Suita-City, Osaka 565-8565 Japan</nlm:aff>
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<affiliation><nlm:aff id="Aff141">Present address: Institut für Zellbiologie des Nervensystems, München, TU Germany</nlm:aff>
<wicri:noCountry code="subfield">TU Germany</wicri:noCountry>
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W12 0NN, London, England UK</nlm:aff>
<wicri:noCountry code="subfield">England UK</wicri:noCountry>
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W12 0NN, London, England UK</nlm:aff>
<wicri:noCountry code="subfield">England UK</wicri:noCountry>
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W12 0NN, London, England UK</nlm:aff>
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<institution>University of Edinburgh,</institution>
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Edinburgh, Scotland EH8 9XD UK</nlm:aff>
<wicri:noCountry code="subfield">Scotland EH8 9XD UK</wicri:noCountry>
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<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
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<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
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<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
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<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
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Cambridge, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
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Cambridge, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
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<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
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<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
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<affiliation><nlm:aff id="Aff193"><institution-wrap><institution-id institution-id-type="GRID">grid.66859.34</institution-id>
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Cambridge, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
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Boston, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
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<affiliation><nlm:aff id="Aff193"><institution-wrap><institution-id institution-id-type="GRID">grid.66859.34</institution-id>
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Cambridge, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
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<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
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<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
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Boston, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
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Boston, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
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Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications</title>
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<author><name sortKey="Chen, Hongxing" sort="Chen, Hongxing" uniqKey="Chen H" first="Hongxing" last="Chen">Hongxing Chen</name>
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<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals,</institution>
</institution-wrap>
Ridgefield, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Ridgefield</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wang, Hong" sort="Wang, Hong" uniqKey="Wang H" first="Hong" last="Wang">Hong Wang</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1312 9717</institution-id>
<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals,</institution>
</institution-wrap>
Ridgefield, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Ridgefield</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Clifford, Holly" sort="Clifford, Holly" uniqKey="Clifford H" first="Holly" last="Clifford">Holly Clifford</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1312 9717</institution-id>
<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals,</institution>
</institution-wrap>
Ridgefield, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Ridgefield</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Qian, Hu Sheng" sort="Qian, Hu Sheng" uniqKey="Qian H" first="Hu Sheng" last="Qian">Hu Sheng Qian</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1312 9717</institution-id>
<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals,</institution>
</institution-wrap>
Ridgefield, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Ridgefield</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wong, Diane" sort="Wong, Diane" uniqKey="Wong D" first="Diane" last="Wong">Diane Wong</name>
<affiliation wicri:level="2"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1312 9717</institution-id>
<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Small Molecule Drug Research, Boehringer Ingelheim Pharmaceuticals,</institution>
</institution-wrap>
Ridgefield, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Ridgefield</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sarko, Chris" sort="Sarko, Chris" uniqKey="Sarko C" first="Chris" last="Sarko">Chris Sarko</name>
<affiliation wicri:level="2"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1312 9717</institution-id>
<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Small Molecule Drug Research, Boehringer Ingelheim Pharmaceuticals,</institution>
</institution-wrap>
Ridgefield, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Ridgefield</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Fryer, Ryan" sort="Fryer, Ryan" uniqKey="Fryer R" first="Ryan" last="Fryer">Ryan Fryer</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1312 9717</institution-id>
<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals,</institution>
</institution-wrap>
Ridgefield, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Ridgefield</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Richman, Jeremy" sort="Richman, Jeremy" uniqKey="Richman J" first="Jeremy" last="Richman">Jeremy Richman</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1312 9717</institution-id>
<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals,</institution>
</institution-wrap>
Ridgefield, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Ridgefield</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Reinhart, Glenn A" sort="Reinhart, Glenn A" uniqKey="Reinhart G" first="Glenn A." last="Reinhart">Glenn A. Reinhart</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1312 9717</institution-id>
<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals,</institution>
</institution-wrap>
Ridgefield, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Ridgefield</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Boustany, Carine M" sort="Boustany, Carine M" uniqKey="Boustany C" first="Carine M." last="Boustany">Carine M. Boustany</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1312 9717</institution-id>
<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals,</institution>
</institution-wrap>
Ridgefield, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Ridgefield</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Pullen, Steven S" sort="Pullen, Steven S" uniqKey="Pullen S" first="Steven S." last="Pullen">Steven S. Pullen</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1312 9717</institution-id>
<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals,</institution>
</institution-wrap>
Ridgefield, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Ridgefield</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Andresen, Henriette" sort="Andresen, Henriette" uniqKey="Andresen H" first="Henriette" last="Andresen">Henriette Andresen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Institute of Experimental Medical Research,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Moltzau, Lise Roman" sort="Moltzau, Lise Roman" uniqKey="Moltzau L" first="Lise Román" last="Moltzau">Lise Román Moltzau</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cataliotti, Alessandro" sort="Cataliotti, Alessandro" uniqKey="Cataliotti A" first="Alessandro" last="Cataliotti">Alessandro Cataliotti</name>
<affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Institute of Experimental Medical Research,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Levy, Finn Olav" sort="Levy, Finn Olav" uniqKey="Levy F" first="Finn Olav" last="Levy">Finn Olav Levy</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lukowski, Robert" sort="Lukowski, Robert" uniqKey="Lukowski R" first="Robert" last="Lukowski">Robert Lukowski</name>
<affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Pharmacology, Toxicology and Clinical Pharmacy,</institution>
<institution>Institute of Pharmacy, University of Tuebingen,</institution>
</institution-wrap>
Tuebingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tuebingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Frankenreiter, Sandra" sort="Frankenreiter, Sandra" uniqKey="Frankenreiter S" first="Sandra" last="Frankenreiter">Sandra Frankenreiter</name>
<affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Pharmacology, Toxicology and Clinical Pharmacy,</institution>
<institution>Institute of Pharmacy, University of Tuebingen,</institution>
</institution-wrap>
Tuebingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tuebingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Friebe, Andreas" sort="Friebe, Andreas" uniqKey="Friebe A" first="Andreas" last="Friebe">Andreas Friebe</name>
<affiliation wicri:level="1"><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Calamaras, Timothy" sort="Calamaras, Timothy" uniqKey="Calamaras T" first="Timothy" last="Calamaras">Timothy Calamaras</name>
<affiliation wicri:level="2"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8934 4045</institution-id>
<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Molecular Cardiology Research Institute, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Baumgartner, Robert" sort="Baumgartner, Robert" uniqKey="Baumgartner R" first="Robert" last="Baumgartner">Robert Baumgartner</name>
<affiliation wicri:level="2"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8934 4045</institution-id>
<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Molecular Cardiology Research Institute, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff11"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0650 7433</institution-id>
<institution-id institution-id-type="GRID">grid.412689.0</institution-id>
<institution>Present Affiliation: Division of Cardiology,</institution>
<institution>University of Pittsburgh Medical Center,</institution>
</institution-wrap>
Pittsburgh, Pennsylvania ,15224 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Pittsburgh, Pennsylvania </wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mclaughlin, Angela" sort="Mclaughlin, Angela" uniqKey="Mclaughlin A" first="Angela" last="Mclaughlin">Angela Mclaughlin</name>
<affiliation wicri:level="2"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8934 4045</institution-id>
<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Molecular Cardiology Research Institute, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff12"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9094</institution-id>
<institution-id institution-id-type="GRID">grid.40263.33</institution-id>
<institution>Present Affiliation: Department of Medicine,</institution>
<institution>Brown University School of Medicine,</institution>
</institution-wrap>
Providence, Rhode Island ,02912 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Providence, Rhode Island </wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aronovitz, Mark" sort="Aronovitz, Mark" uniqKey="Aronovitz M" first="Mark" last="Aronovitz">Mark Aronovitz</name>
<affiliation wicri:level="2"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8934 4045</institution-id>
<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Molecular Cardiology Research Institute, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Baur, Wendy" sort="Baur, Wendy" uniqKey="Baur W" first="Wendy" last="Baur">Wendy Baur</name>
<affiliation wicri:level="2"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8934 4045</institution-id>
<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Molecular Cardiology Research Institute, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wang, Guang Rong" sort="Wang, Guang Rong" uniqKey="Wang G" first="Guang-Rong" last="Wang">Guang-Rong Wang</name>
<affiliation wicri:level="2"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8934 4045</institution-id>
<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Molecular Cardiology Research Institute, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kapur, Navin" sort="Kapur, Navin" uniqKey="Kapur N" first="Navin" last="Kapur">Navin Kapur</name>
<affiliation wicri:level="2"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8934 4045</institution-id>
<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Molecular Cardiology Research Institute, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff13"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8934 4045</institution-id>
<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Division of Cardiology, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Karas, Richard" sort="Karas, Richard" uniqKey="Karas R" first="Richard" last="Karas">Richard Karas</name>
<affiliation wicri:level="2"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8934 4045</institution-id>
<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Molecular Cardiology Research Institute, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff13"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8934 4045</institution-id>
<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Division of Cardiology, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Blanton, Robert" sort="Blanton, Robert" uniqKey="Blanton R" first="Robert" last="Blanton">Robert Blanton</name>
<affiliation wicri:level="2"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8934 4045</institution-id>
<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Molecular Cardiology Research Institute, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff13"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8934 4045</institution-id>
<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Division of Cardiology, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hell, Stefan" sort="Hell, Stefan" uniqKey="Hell S" first="Stefan" last="Hell">Stefan Hell</name>
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<institution-id institution-id-type="GRID">grid.418140.8</institution-id>
<institution>Max Planck Institute for Biophysical Chemistry, Göttingen and German Cancer Research Center (DKFZ),</institution>
</institution-wrap>
Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Waldman, Scott A" sort="Waldman, Scott A" uniqKey="Waldman S" first="Scott A." last="Waldman">Scott A. Waldman</name>
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<institution-id institution-id-type="GRID">grid.265008.9</institution-id>
<institution>Department of Pharmacology and Experimental Therapeutics,</institution>
<institution>Thomas Jefferson University,</institution>
</institution-wrap>
Philadelphia, Pennsylvania 19107 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lin, Jieru E" sort="Lin, Jieru E" uniqKey="Lin J" first="Jieru E." last="Lin">Jieru E. Lin</name>
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<institution-id institution-id-type="GRID">grid.265008.9</institution-id>
<institution>Department of Pharmacology and Experimental Therapeutics,</institution>
<institution>Thomas Jefferson University,</institution>
</institution-wrap>
Philadelphia, Pennsylvania 19107 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Colon Gonzalez, Francheska" sort="Colon Gonzalez, Francheska" uniqKey="Colon Gonzalez F" first="Francheska" last="Colon-Gonzalez">Francheska Colon-Gonzalez</name>
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<institution-id institution-id-type="GRID">grid.265008.9</institution-id>
<institution>Department of Pharmacology and Experimental Therapeutics,</institution>
<institution>Thomas Jefferson University,</institution>
</institution-wrap>
Philadelphia, Pennsylvania 19107 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kim, Gilbert W" sort="Kim, Gilbert W" uniqKey="Kim G" first="Gilbert W." last="Kim">Gilbert W. Kim</name>
<affiliation wicri:level="2"><nlm:aff id="Aff15"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2166 5843</institution-id>
<institution-id institution-id-type="GRID">grid.265008.9</institution-id>
<institution>Department of Pharmacology and Experimental Therapeutics,</institution>
<institution>Thomas Jefferson University,</institution>
</institution-wrap>
Philadelphia, Pennsylvania 19107 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Blomain, Erik S" sort="Blomain, Erik S" uniqKey="Blomain E" first="Erik S." last="Blomain">Erik S. Blomain</name>
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<institution-id institution-id-type="GRID">grid.265008.9</institution-id>
<institution>Department of Pharmacology and Experimental Therapeutics,</institution>
<institution>Thomas Jefferson University,</institution>
</institution-wrap>
Philadelphia, Pennsylvania 19107 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Merlino, Dante" sort="Merlino, Dante" uniqKey="Merlino D" first="Dante" last="Merlino">Dante Merlino</name>
<affiliation wicri:level="2"><nlm:aff id="Aff15"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2166 5843</institution-id>
<institution-id institution-id-type="GRID">grid.265008.9</institution-id>
<institution>Department of Pharmacology and Experimental Therapeutics,</institution>
<institution>Thomas Jefferson University,</institution>
</institution-wrap>
Philadelphia, Pennsylvania 19107 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Snook, Adam" sort="Snook, Adam" uniqKey="Snook A" first="Adam" last="Snook">Adam Snook</name>
<affiliation wicri:level="2"><nlm:aff id="Aff15"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2166 5843</institution-id>
<institution-id institution-id-type="GRID">grid.265008.9</institution-id>
<institution>Department of Pharmacology and Experimental Therapeutics,</institution>
<institution>Thomas Jefferson University,</institution>
</institution-wrap>
Philadelphia, Pennsylvania 19107 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Erdmann, Jeanette" sort="Erdmann, Jeanette" uniqKey="Erdmann J" first="Jeanette" last="Erdmann">Jeanette Erdmann</name>
<affiliation wicri:level="1"><nlm:aff id="Aff16"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0057 2672</institution-id>
<institution-id institution-id-type="GRID">grid.4562.5</institution-id>
<institution>Institut für Kardiogenetik and Universitäres Herzzentrum Lübeck, Universität zu Lübeck, Lübeck, Germany & DZHK e.V. (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck,</institution>
</institution-wrap>
Lübeck, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Lübeck</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wobst, Jana" sort="Wobst, Jana" uniqKey="Wobst J" first="Jana" last="Wobst">Jana Wobst</name>
<affiliation wicri:level="1"><nlm:aff id="Aff17"><institution-wrap><institution-id institution-id-type="ISNI">0000000123222966</institution-id>
<institution-id institution-id-type="GRID">grid.6936.a</institution-id>
<institution>Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen,</institution>
<institution>Technische Universität München,</institution>
</institution-wrap>
Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Munich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kessler, Thorsten" sort="Kessler, Thorsten" uniqKey="Kessler T" first="Thorsten" last="Kessler">Thorsten Kessler</name>
<affiliation wicri:level="1"><nlm:aff id="Aff17"><institution-wrap><institution-id institution-id-type="ISNI">0000000123222966</institution-id>
<institution-id institution-id-type="GRID">grid.6936.a</institution-id>
<institution>Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen,</institution>
<institution>Technische Universität München,</institution>
</institution-wrap>
Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Munich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schunkert, Heribert" sort="Schunkert, Heribert" uniqKey="Schunkert H" first="Heribert" last="Schunkert">Heribert Schunkert</name>
<affiliation wicri:level="1"><nlm:aff id="Aff17"><institution-wrap><institution-id institution-id-type="ISNI">0000000123222966</institution-id>
<institution-id institution-id-type="GRID">grid.6936.a</institution-id>
<institution>Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen,</institution>
<institution>Technische Universität München,</institution>
</institution-wrap>
Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Munich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Walter, Ulrich" sort="Walter, Ulrich" uniqKey="Walter U" first="Ulrich" last="Walter">Ulrich Walter</name>
<affiliation wicri:level="1"><nlm:aff id="Aff18"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1941 7111</institution-id>
<institution-id institution-id-type="GRID">grid.5802.f</institution-id>
<institution>Center for Thrombosis & Hemostasis,</institution>
<institution>Universitätsklinikum der Johannes Gutenberg-Universität Mainz,</institution>
</institution-wrap>
Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Mainz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pagel, Oliver" sort="Pagel, Oliver" uniqKey="Pagel O" first="Oliver" last="Pagel">Oliver Pagel</name>
<affiliation wicri:level="1"><nlm:aff id="Aff19"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0492 9407</institution-id>
<institution-id institution-id-type="GRID">grid.419243.9</institution-id>
<institution>Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V,</institution>
</institution-wrap>
Dortmund, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dortmund</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Walter, Elena" sort="Walter, Elena" uniqKey="Walter E" first="Elena" last="Walter">Elena Walter</name>
<affiliation wicri:level="1"><nlm:aff id="Aff18"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1941 7111</institution-id>
<institution-id institution-id-type="GRID">grid.5802.f</institution-id>
<institution>Center for Thrombosis & Hemostasis,</institution>
<institution>Universitätsklinikum der Johannes Gutenberg-Universität Mainz,</institution>
</institution-wrap>
Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Mainz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gambaryan, Stepan" sort="Gambaryan, Stepan" uniqKey="Gambaryan S" first="Stepan" last="Gambaryan">Stepan Gambaryan</name>
<affiliation wicri:level="1"><nlm:aff id="Aff18"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1941 7111</institution-id>
<institution-id institution-id-type="GRID">grid.5802.f</institution-id>
<institution>Center for Thrombosis & Hemostasis,</institution>
<institution>Universitätsklinikum der Johannes Gutenberg-Universität Mainz,</institution>
</institution-wrap>
Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Mainz</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff20"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0440 2269</institution-id>
<institution-id institution-id-type="GRID">grid.419730.8</institution-id>
<institution>Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences,</institution>
</institution-wrap>
St. Petersburg, Russia</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>St. Petersburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Smolenski, Albert" sort="Smolenski, Albert" uniqKey="Smolenski A" first="Albert" last="Smolenski">Albert Smolenski</name>
<affiliation wicri:level="1"><nlm:aff id="Aff21"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0768 2743</institution-id>
<institution-id institution-id-type="GRID">grid.7886.1</institution-id>
<institution>UCD Conway Institute, UCD School of Medicine and Medical Science,</institution>
<institution>University College Dublin,</institution>
</institution-wrap>
Dublin, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Dublin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jurk, Kerstin" sort="Jurk, Kerstin" uniqKey="Jurk K" first="Kerstin" last="Jurk">Kerstin Jurk</name>
<affiliation wicri:level="1"><nlm:aff id="Aff18"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1941 7111</institution-id>
<institution-id institution-id-type="GRID">grid.5802.f</institution-id>
<institution>Center for Thrombosis & Hemostasis,</institution>
<institution>Universitätsklinikum der Johannes Gutenberg-Universität Mainz,</institution>
</institution-wrap>
Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Mainz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zahedi, Rene" sort="Zahedi, Rene" uniqKey="Zahedi R" first="Rene" last="Zahedi">Rene Zahedi</name>
<affiliation wicri:level="1"><nlm:aff id="Aff19"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0492 9407</institution-id>
<institution-id institution-id-type="GRID">grid.419243.9</institution-id>
<institution>Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V,</institution>
</institution-wrap>
Dortmund, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dortmund</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Klinger, James R" sort="Klinger, James R" uniqKey="Klinger J" first="James R." last="Klinger">James R. Klinger</name>
<affiliation wicri:level="2"><nlm:aff id="Aff22"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9094</institution-id>
<institution-id institution-id-type="GRID">grid.40263.33</institution-id>
<institution>Division of Pulmonary, Sleep and Critical Care Medicine, Rhode Island Hospital,</institution>
<institution>Alpert Medical School of Brown University,</institution>
</institution-wrap>
Providence, RI USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Rhode Island</region>
</placeName>
<wicri:cityArea>Providence</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Benza, Raymond L" sort="Benza, Raymond L" uniqKey="Benza R" first="Raymond L." last="Benza">Raymond L. Benza</name>
<affiliation wicri:level="2"><nlm:aff id="Aff23"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0455 1168</institution-id>
<institution-id institution-id-type="GRID">grid.413621.3</institution-id>
<institution>Cardiovascular Institute, Allegheny General Hospital,</institution>
</institution-wrap>
Pittsburgh, PA USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Pittsburgh</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Corris, Paul A" sort="Corris, Paul A" uniqKey="Corris P" first="Paul A." last="Corris">Paul A. Corris</name>
<affiliation wicri:level="1"><nlm:aff id="Aff24"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0462 7212</institution-id>
<institution-id institution-id-type="GRID">grid.1006.7</institution-id>
<institution>Institute of Cellular Medicine,</institution>
<institution>Newcastle University,</institution>
</institution-wrap>
Newcastle, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Newcastle</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Langleben, David" sort="Langleben, David" uniqKey="Langleben D" first="David" last="Langleben">David Langleben</name>
<affiliation><nlm:aff id="Aff25"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8649</institution-id>
<institution-id institution-id-type="GRID">grid.14709.3b</institution-id>
<institution>Center for Pulmonary Vascular Disease and Lady Davis Institute, Jewish General Hospital,</institution>
<institution>McGill University,</institution>
</institution-wrap>
Montreal, QC Canada</nlm:aff>
<wicri:noCountry code="subfield">QC Canada</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Naeije, Robert" sort="Naeije, Robert" uniqKey="Naeije R" first="Robert" last="Naeije">Robert Naeije</name>
<affiliation wicri:level="1"><nlm:aff id="Aff26"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8571 829X</institution-id>
<institution-id institution-id-type="GRID">grid.412157.4</institution-id>
<institution>Department of Cardiology,</institution>
<institution>Erasme University Hospital,</institution>
</institution-wrap>
Brussels, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Brussels</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Simonneau, Gerald" sort="Simonneau, Gerald" uniqKey="Simonneau G" first="Gérald" last="Simonneau">Gérald Simonneau</name>
<affiliation wicri:level="1"><nlm:aff id="Aff27"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 2558</institution-id>
<institution-id institution-id-type="GRID">grid.5842.b</institution-id>
<institution>Assistance Publique–Hôpitaux de Paris, Service de Pneumologie, Hôpital Bicêtre,</institution>
<institution>Université Paris-Sud, Laboratoire d’Excellence en Recherche sur le Médicament et Innovation Thérapeutique, and INSERM Unité 999,</institution>
</institution-wrap>
Le Kremlin–Bicêtre, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Le Kremlin–Bicêtre</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meier, Christian" sort="Meier, Christian" uniqKey="Meier C" first="Christian" last="Meier">Christian Meier</name>
<affiliation wicri:level="1"><nlm:aff id="Aff28"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Global Clinical Development, Bayer AG,</institution>
</institution-wrap>
Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Colorado, Pablo" sort="Colorado, Pablo" uniqKey="Colorado P" first="Pablo" last="Colorado">Pablo Colorado</name>
<affiliation wicri:level="1"><nlm:aff id="Aff29">Global Clinical Development, Bayer HealthCare Pharmaceuticals, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Global Clinical Development, Bayer HealthCare Pharmaceuticals, Barcelona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chang, Mi Kyung" sort="Chang, Mi Kyung" uniqKey="Chang M" first="Mi Kyung" last="Chang">Mi Kyung Chang</name>
<affiliation wicri:level="1"><nlm:aff id="Aff28"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Global Clinical Development, Bayer AG,</institution>
</institution-wrap>
Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Busse, Dennis" sort="Busse, Dennis" uniqKey="Busse D" first="Dennis" last="Busse">Dennis Busse</name>
<affiliation wicri:level="1"><nlm:aff id="Aff30">Chrestos Concept GmbH & Co, Essen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Chrestos Concept GmbH & Co, Essen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hoeper, Marius M" sort="Hoeper, Marius M" uniqKey="Hoeper M" first="Marius M." last="Hoeper">Marius M. Hoeper</name>
<affiliation wicri:level="1"><nlm:aff id="Aff31"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9529 9877</institution-id>
<institution-id institution-id-type="GRID">grid.10423.34</institution-id>
<institution>Clinic for Respiratory Medicine, Hannover Medical School,</institution>
</institution-wrap>
Hannover, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hannover</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Masferrer, Jaime L" sort="Masferrer, Jaime L" uniqKey="Masferrer J" first="Jaime L." last="Masferrer">Jaime L. Masferrer</name>
<affiliation wicri:level="2"><nlm:aff id="Aff32"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jacobson, Sarah" sort="Jacobson, Sarah" uniqKey="Jacobson S" first="Sarah" last="Jacobson">Sarah Jacobson</name>
<affiliation wicri:level="2"><nlm:aff id="Aff32"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Liu, Guang" sort="Liu, Guang" uniqKey="Liu G" first="Guang" last="Liu">Guang Liu</name>
<affiliation wicri:level="2"><nlm:aff id="Aff32"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sarno, Renee" sort="Sarno, Renee" uniqKey="Sarno R" first="Renee" last="Sarno">Renee Sarno</name>
<affiliation wicri:level="2"><nlm:aff id="Aff32"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bernier, Sylvie" sort="Bernier, Sylvie" uniqKey="Bernier S" first="Sylvie" last="Bernier">Sylvie Bernier</name>
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<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
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Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zhang, Ping" sort="Zhang, Ping" uniqKey="Zhang P" first="Ping" last="Zhang">Ping Zhang</name>
</author>
<author><name sortKey="Todd Milne, G" sort="Todd Milne, G" uniqKey="Todd Milne G" first="G." last="Todd Milne">G. Todd Milne</name>
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<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Flores Costa, Roger" sort="Flores Costa, Roger" uniqKey="Flores Costa R" first="Roger" last="Flores-Costa">Roger Flores-Costa</name>
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<institution-id institution-id-type="GRID">grid.410458.c</institution-id>
<institution>Department of Biochemistry and Molecular Genetics,</institution>
<institution>Hospital Clinic-University of Barcelona,</institution>
</institution-wrap>
Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Barcelona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Currie, Mark" sort="Currie, Mark" uniqKey="Currie M" first="Mark" last="Currie">Mark Currie</name>
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<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hall, Katherine" sort="Hall, Katherine" uniqKey="Hall K" first="Katherine" last="Hall">Katherine Hall</name>
<affiliation wicri:level="2"><nlm:aff id="Aff32"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mohrle, Dorit" sort="Mohrle, Dorit" uniqKey="Mohrle D" first="Dorit" last="Möhrle">Dorit Möhrle</name>
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<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Elfriede-Aulhorn-Straße 5, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Elfriede-Aulhorn-Straße 5, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Reimann, Katrin" sort="Reimann, Katrin" uniqKey="Reimann K" first="Katrin" last="Reimann">Katrin Reimann</name>
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<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Elfriede-Aulhorn-Straße 5, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Elfriede-Aulhorn-Straße 5, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wolter, Steffen" sort="Wolter, Steffen" uniqKey="Wolter S" first="Steffen" last="Wolter">Steffen Wolter</name>
<affiliation wicri:level="1"><nlm:aff id="Aff34"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Elfriede-Aulhorn-Straße 5, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Elfriede-Aulhorn-Straße 5, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wolters, Markus" sort="Wolters, Markus" uniqKey="Wolters M" first="Markus" last="Wolters">Markus Wolters</name>
<affiliation wicri:level="1"><nlm:aff id="Aff35"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfaculty Institute of Biochemistry,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Hoppe-Seyler-Straße 4, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hoppe-Seyler-Straße 4, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mergia, Evanthia" sort="Mergia, Evanthia" uniqKey="Mergia E" first="Evanthia" last="Mergia">Evanthia Mergia</name>
<affiliation wicri:level="1"><nlm:aff id="Aff36"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Bochum, Universitätsstr 150,</institution>
</institution-wrap>
44780 Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>44780 Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eichert, Nicole" sort="Eichert, Nicole" uniqKey="Eichert N" first="Nicole" last="Eichert">Nicole Eichert</name>
<affiliation wicri:level="1"><nlm:aff id="Aff34"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Elfriede-Aulhorn-Straße 5, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Elfriede-Aulhorn-Straße 5, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Geisler, Hyun Soon" sort="Geisler, Hyun Soon" uniqKey="Geisler H" first="Hyun-Soon" last="Geisler">Hyun-Soon Geisler</name>
<affiliation wicri:level="1"><nlm:aff id="Aff34"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Elfriede-Aulhorn-Straße 5, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Elfriede-Aulhorn-Straße 5, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ruth, Peter" sort="Ruth, Peter" uniqKey="Ruth P" first="Peter" last="Ruth">Peter Ruth</name>
<affiliation wicri:level="1"><nlm:aff id="Aff37"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Auf der Morgenstelle 8, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Auf der Morgenstelle 8, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Friebe, Andreas" sort="Friebe, Andreas" uniqKey="Friebe A" first="Andreas" last="Friebe">Andreas Friebe</name>
<affiliation wicri:level="1"><nlm:aff id="Aff38"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Department of Physiology,</institution>
<institution>University of Würzburg,</institution>
</institution-wrap>
Röntgenring 9, 97070 Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Röntgenring 9, 97070 Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Feil, Robert" sort="Feil, Robert" uniqKey="Feil R" first="Robert" last="Feil">Robert Feil</name>
<affiliation wicri:level="1"><nlm:aff id="Aff35"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfaculty Institute of Biochemistry,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Hoppe-Seyler-Straße 4, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hoppe-Seyler-Straße 4, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zimmermann, Ulrike" sort="Zimmermann, Ulrike" uniqKey="Zimmermann U" first="Ulrike" last="Zimmermann">Ulrike Zimmermann</name>
<affiliation wicri:level="1"><nlm:aff id="Aff34"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Elfriede-Aulhorn-Straße 5, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Elfriede-Aulhorn-Straße 5, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koesling, Doris" sort="Koesling, Doris" uniqKey="Koesling D" first="Doris" last="Koesling">Doris Koesling</name>
<affiliation wicri:level="1"><nlm:aff id="Aff36"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Bochum, Universitätsstr 150,</institution>
</institution-wrap>
44780 Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>44780 Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Knipper, Marlies" sort="Knipper, Marlies" uniqKey="Knipper M" first="Marlies" last="Knipper">Marlies Knipper</name>
<affiliation wicri:level="1"><nlm:aff id="Aff34"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Elfriede-Aulhorn-Straße 5, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Elfriede-Aulhorn-Straße 5, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ruttiger, Lukas" sort="Ruttiger, Lukas" uniqKey="Ruttiger L" first="Lukas" last="Rüttiger">Lukas Rüttiger</name>
<affiliation wicri:level="1"><nlm:aff id="Aff34"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Elfriede-Aulhorn-Straße 5, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Elfriede-Aulhorn-Straße 5, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tanaka, Yasutake" sort="Tanaka, Yasutake" uniqKey="Tanaka Y" first="Yasutake" last="Tanaka">Yasutake Tanaka</name>
<affiliation wicri:level="1"><nlm:aff id="Aff39"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Okamoto, Atsuko" sort="Okamoto, Atsuko" uniqKey="Okamoto A" first="Atsuko" last="Okamoto">Atsuko Okamoto</name>
<affiliation wicri:level="1"><nlm:aff id="Aff39"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nojiri, Takashi" sort="Nojiri, Takashi" uniqKey="Nojiri T" first="Takashi" last="Nojiri">Takashi Nojiri</name>
<affiliation wicri:level="1"><nlm:aff id="Aff39"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff40"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0373 3971</institution-id>
<institution-id institution-id-type="GRID">grid.136593.b</institution-id>
<institution>Department of General Thoracic Surgery,</institution>
<institution>Osaka University Graduate School of Medicine,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kumazoe, Motofumi" sort="Kumazoe, Motofumi" uniqKey="Kumazoe M" first="Motofumi" last="Kumazoe">Motofumi Kumazoe</name>
<affiliation wicri:level="1"><nlm:aff id="Aff39"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tokudome, Takeshi" sort="Tokudome, Takeshi" uniqKey="Tokudome T" first="Takeshi" last="Tokudome">Takeshi Tokudome</name>
<affiliation wicri:level="1"><nlm:aff id="Aff39"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Miura, Koichi" sort="Miura, Koichi" uniqKey="Miura K" first="Koichi" last="Miura">Koichi Miura</name>
<affiliation wicri:level="1"><nlm:aff id="Aff39"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hino, Jun" sort="Hino, Jun" uniqKey="Hino J" first="Jun" last="Hino">Jun Hino</name>
<affiliation wicri:level="1"><nlm:aff id="Aff39"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hosoda, Hiroshi" sort="Hosoda, Hiroshi" uniqKey="Hosoda H" first="Hiroshi" last="Hosoda">Hiroshi Hosoda</name>
<affiliation wicri:level="1"><nlm:aff id="Aff41"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Miyazato, Mikiya" sort="Miyazato, Mikiya" uniqKey="Miyazato M" first="Mikiya" last="Miyazato">Mikiya Miyazato</name>
<affiliation wicri:level="1"><nlm:aff id="Aff39"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kangawa, Kenji" sort="Kangawa, Kenji" uniqKey="Kangawa K" first="Kenji" last="Kangawa">Kenji Kangawa</name>
<affiliation wicri:level="1"><nlm:aff id="Aff39"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kapil, Vikas" sort="Kapil, Vikas" uniqKey="Kapil V" first="Vikas" last="Kapil">Vikas Kapil</name>
<affiliation wicri:level="1"><nlm:aff id="Aff42"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, Barts & The London School of Medicine, QMUL,</institution>
</institution-wrap>
London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ahluwalia, Amrita" sort="Ahluwalia, Amrita" uniqKey="Ahluwalia A" first="Amrita" last="Ahluwalia">Amrita Ahluwalia</name>
<affiliation wicri:level="1"><nlm:aff id="Aff42"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, Barts & The London School of Medicine, QMUL,</institution>
</institution-wrap>
London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Paolocci, Nazareno" sort="Paolocci, Nazareno" uniqKey="Paolocci N" first="Nazareno" last="Paolocci">Nazareno Paolocci</name>
<affiliation><nlm:aff id="Aff43"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 9311</institution-id>
<institution-id institution-id-type="GRID">grid.21107.35</institution-id>
<institution>Division of Cardiology, Department of Medicine,</institution>
<institution>Johns Hopkins Medical Institutions,</institution>
</institution-wrap>
Baltimore, Maryland USA</nlm:aff>
<wicri:noCountry code="subfield">Maryland USA</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff44"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1757 3630</institution-id>
<institution-id institution-id-type="GRID">grid.9027.c</institution-id>
<institution>Department of Experimental Medicine,</institution>
<institution>University of Perugia,</institution>
</institution-wrap>
06123 Perugia, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>06123 Perugia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eaton, Philip" sort="Eaton, Philip" uniqKey="Eaton P" first="Philip" last="Eaton">Philip Eaton</name>
<affiliation wicri:level="1"><nlm:aff id="Aff45"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>King’s College London, Cardiovascular Division, The Rayne Institute,</institution>
</institution-wrap>
St Thomas’ Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>St Thomas’ Hospital, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Campbell, James C" sort="Campbell, James C" uniqKey="Campbell J" first="James C." last="Campbell">James C. Campbell</name>
<affiliation wicri:level="2"><nlm:aff id="Aff46"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Structural and Computational Biology and Molecular Biophysics Program,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, TX USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Houston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff47"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, TX USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Henning, Philipp" sort="Henning, Philipp" uniqKey="Henning P" first="Philipp" last="Henning">Philipp Henning</name>
<affiliation><nlm:aff id="Aff48"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1089 1036</institution-id>
<institution-id institution-id-type="GRID">grid.5155.4</institution-id>
<institution>Department of Biochemistry,</institution>
<institution>University of Kassel,</institution>
</institution-wrap>
Kassel, Hesse Germany</nlm:aff>
<wicri:noCountry code="subfield">Hesse Germany</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Franz, Eugen" sort="Franz, Eugen" uniqKey="Franz E" first="Eugen" last="Franz">Eugen Franz</name>
<affiliation><nlm:aff id="Aff48"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1089 1036</institution-id>
<institution-id institution-id-type="GRID">grid.5155.4</institution-id>
<institution>Department of Biochemistry,</institution>
<institution>University of Kassel,</institution>
</institution-wrap>
Kassel, Hesse Germany</nlm:aff>
<wicri:noCountry code="subfield">Hesse Germany</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sankaran, Banumathi" sort="Sankaran, Banumathi" uniqKey="Sankaran B" first="Banumathi" last="Sankaran">Banumathi Sankaran</name>
<affiliation wicri:level="2"><nlm:aff id="Aff49"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2231 4551</institution-id>
<institution-id institution-id-type="GRID">grid.184769.5</institution-id>
<institution>Berkeley Center for Structural Biology, Lawrence Berkeley National Laboratory,</institution>
</institution-wrap>
Berkeley, CA USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Berkeley</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Herberg, Friedrich W" sort="Herberg, Friedrich W" uniqKey="Herberg F" first="Friedrich W." last="Herberg">Friedrich W. Herberg</name>
<affiliation wicri:level="2"><nlm:aff id="Aff49"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2231 4551</institution-id>
<institution-id institution-id-type="GRID">grid.184769.5</institution-id>
<institution>Berkeley Center for Structural Biology, Lawrence Berkeley National Laboratory,</institution>
</institution-wrap>
Berkeley, CA USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Berkeley</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kim, Choel" sort="Kim, Choel" uniqKey="Kim C" first="Choel" last="Kim">Choel Kim</name>
<affiliation wicri:level="2"><nlm:aff id="Aff46"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Structural and Computational Biology and Molecular Biophysics Program,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, TX USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Houston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff47"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, TX USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Houston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff50"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Verna and Marrs McLean Department of Biochemistry and Molecular Biology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, TX USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wittwer, M" sort="Wittwer, M" uniqKey="Wittwer M" first="M." last="Wittwer">M. Wittwer</name>
<affiliation wicri:level="1"><nlm:aff id="Aff51"><institution-wrap><institution-id institution-id-type="ISNI">0000000123222966</institution-id>
<institution-id institution-id-type="GRID">grid.6936.a</institution-id>
<institution>Technische Universität München, Department of Chemistry, Biomolecular NMR Spectroscopy,</institution>
</institution-wrap>
Garching, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Garching</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Luo, Q" sort="Luo, Q" uniqKey="Luo Q" first="Q." last="Luo">Q. Luo</name>
<affiliation wicri:level="1"><nlm:aff id="Aff52"><institution-wrap><institution-id institution-id-type="ISNI">0000000123222966</institution-id>
<institution-id institution-id-type="GRID">grid.6936.a</institution-id>
<institution>Technische Universität München, Department of Chemistry, Computational Biocatalysis,</institution>
</institution-wrap>
Garching, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Garching</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kaila, V" sort="Kaila, V" uniqKey="Kaila V" first="V." last="Kaila">V. Kaila</name>
<affiliation wicri:level="1"><nlm:aff id="Aff52"><institution-wrap><institution-id institution-id-type="ISNI">0000000123222966</institution-id>
<institution-id institution-id-type="GRID">grid.6936.a</institution-id>
<institution>Technische Universität München, Department of Chemistry, Computational Biocatalysis,</institution>
</institution-wrap>
Garching, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Garching</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dames, S A" sort="Dames, S A" uniqKey="Dames S" first="S. A." last="Dames">S. A. Dames</name>
<affiliation wicri:level="1"><nlm:aff id="Aff51"><institution-wrap><institution-id institution-id-type="ISNI">0000000123222966</institution-id>
<institution-id institution-id-type="GRID">grid.6936.a</institution-id>
<institution>Technische Universität München, Department of Chemistry, Biomolecular NMR Spectroscopy,</institution>
</institution-wrap>
Garching, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Garching</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff53"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0483 2525</institution-id>
<institution-id institution-id-type="GRID">grid.4567.0</institution-id>
<institution>Institute of Structural Biology, Helmholtz Zentrum München,</institution>
</institution-wrap>
Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Neuherberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tobin, Andrew" sort="Tobin, Andrew" uniqKey="Tobin A" first="Andrew" last="Tobin">Andrew Tobin</name>
<affiliation wicri:level="1"><nlm:aff id="Aff54"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2193 314X</institution-id>
<institution-id institution-id-type="GRID">grid.8756.c</institution-id>
<institution>Institute of Molecular Cell and Systems Biology,</institution>
<institution>University of Glasgow,</institution>
</institution-wrap>
Glasgow, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Glasgow</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alam, Mahmood" sort="Alam, Mahmood" uniqKey="Alam M" first="Mahmood" last="Alam">Mahmood Alam</name>
<affiliation wicri:level="1"><nlm:aff id="Aff54"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2193 314X</institution-id>
<institution-id institution-id-type="GRID">grid.8756.c</institution-id>
<institution>Institute of Molecular Cell and Systems Biology,</institution>
<institution>University of Glasgow,</institution>
</institution-wrap>
Glasgow, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Glasgow</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rudyk, Olena" sort="Rudyk, Olena" uniqKey="Rudyk O" first="Olena" last="Rudyk">Olena Rudyk</name>
<affiliation><nlm:aff id="Aff55"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>BHF Centre of Research Excellence, King’s College London,</institution>
</institution-wrap>
London, SE1 7EH UK</nlm:aff>
<wicri:noCountry code="subfield">SE1 7EH UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Krasemann, Susanne" sort="Krasemann, Susanne" uniqKey="Krasemann S" first="Susanne" last="Krasemann">Susanne Krasemann</name>
<affiliation wicri:level="1"><nlm:aff id="Aff56"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Core Facility for Mouse Pathology,</institution>
<institution>University Medical Centre Hamburg-Eppendorf,</institution>
</institution-wrap>
20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>20246 Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hartmann, Kristin" sort="Hartmann, Kristin" uniqKey="Hartmann K" first="Kristin" last="Hartmann">Kristin Hartmann</name>
<affiliation wicri:level="1"><nlm:aff id="Aff56"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Core Facility for Mouse Pathology,</institution>
<institution>University Medical Centre Hamburg-Eppendorf,</institution>
</institution-wrap>
20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>20246 Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Prysyazhna, Oleksandra" sort="Prysyazhna, Oleksandra" uniqKey="Prysyazhna O" first="Oleksandra" last="Prysyazhna">Oleksandra Prysyazhna</name>
<affiliation><nlm:aff id="Aff55"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>BHF Centre of Research Excellence, King’s College London,</institution>
</institution-wrap>
London, SE1 7EH UK</nlm:aff>
<wicri:noCountry code="subfield">SE1 7EH UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Zhang, Min" sort="Zhang, Min" uniqKey="Zhang M" first="Min" last="Zhang">Min Zhang</name>
<affiliation><nlm:aff id="Aff55"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>BHF Centre of Research Excellence, King’s College London,</institution>
</institution-wrap>
London, SE1 7EH UK</nlm:aff>
<wicri:noCountry code="subfield">SE1 7EH UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Zhao, Lan" sort="Zhao, Lan" uniqKey="Zhao L" first="Lan" last="Zhao">Lan Zhao</name>
<affiliation><nlm:aff id="Aff57"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2113 8111</institution-id>
<institution-id institution-id-type="GRID">grid.7445.2</institution-id>
<institution>Faculty of Medicine, Department of Medicine, Imperial College London,</institution>
</institution-wrap>
London, SW7 2AZ UK</nlm:aff>
<wicri:noCountry code="subfield">SW7 2AZ UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Weiss, Astrid" sort="Weiss, Astrid" uniqKey="Weiss A" first="Astrid" last="Weiss">Astrid Weiss</name>
<affiliation wicri:level="1"><nlm:aff id="Aff58"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2165 8627</institution-id>
<institution-id institution-id-type="GRID">grid.8664.c</institution-id>
<institution>Excellence Cluster Cardio-Pulmonary System,</institution>
<institution>Universities of Giessen and Marburg Lung Centre Member of the German Lung Canter Justus-Liebig-University Giessen,</institution>
</institution-wrap>
Giessen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Giessen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schermuly, Ralph" sort="Schermuly, Ralph" uniqKey="Schermuly R" first="Ralph" last="Schermuly">Ralph Schermuly</name>
<affiliation wicri:level="1"><nlm:aff id="Aff58"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2165 8627</institution-id>
<institution-id institution-id-type="GRID">grid.8664.c</institution-id>
<institution>Excellence Cluster Cardio-Pulmonary System,</institution>
<institution>Universities of Giessen and Marburg Lung Centre Member of the German Lung Canter Justus-Liebig-University Giessen,</institution>
</institution-wrap>
Giessen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Giessen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eaton, Philip" sort="Eaton, Philip" uniqKey="Eaton P" first="Philip" last="Eaton">Philip Eaton</name>
<affiliation><nlm:aff id="Aff55"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>BHF Centre of Research Excellence, King’s College London,</institution>
</institution-wrap>
London, SE1 7EH UK</nlm:aff>
<wicri:noCountry code="subfield">SE1 7EH UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Moyes, Amie J" sort="Moyes, Amie J" uniqKey="Moyes A" first="Amie J." last="Moyes">Amie J. Moyes</name>
<affiliation wicri:level="1"><nlm:aff id="Aff59"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, Barts & The London School of Medicine, QMUL,</institution>
</institution-wrap>
London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chu, Sandy M" sort="Chu, Sandy M" uniqKey="Chu S" first="Sandy M." last="Chu">Sandy M. Chu</name>
<affiliation wicri:level="1"><nlm:aff id="Aff59"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, Barts & The London School of Medicine, QMUL,</institution>
</institution-wrap>
London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Baliga, Reshma S" sort="Baliga, Reshma S" uniqKey="Baliga R" first="Reshma S." last="Baliga">Reshma S. Baliga</name>
<affiliation wicri:level="1"><nlm:aff id="Aff59"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, Barts & The London School of Medicine, QMUL,</institution>
</institution-wrap>
London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hobbs, Adrian J" sort="Hobbs, Adrian J" uniqKey="Hobbs A" first="Adrian J." last="Hobbs">Adrian J. Hobbs</name>
<affiliation wicri:level="1"><nlm:aff id="Aff59"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, Barts & The London School of Medicine, QMUL,</institution>
</institution-wrap>
London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Michalakis, Stylianos" sort="Michalakis, Stylianos" uniqKey="Michalakis S" first="Stylianos" last="Michalakis">Stylianos Michalakis</name>
<affiliation wicri:level="1"><nlm:aff id="Aff60"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 973X</institution-id>
<institution-id institution-id-type="GRID">grid.5252.0</institution-id>
<institution>Center for Integrated Protein Science Munich CiPSM at the Department of Pharmacy – Center for Drug Research,</institution>
<institution>Ludwig-Maximilians-Universität München,</institution>
</institution-wrap>
Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Munich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Muhlfriedel, Regine" sort="Muhlfriedel, Regine" uniqKey="Muhlfriedel R" first="Regine" last="Mühlfriedel">Regine Mühlfriedel</name>
<affiliation wicri:level="1"><nlm:aff id="Aff61">Institute for Ophthalmic Research, Centre for OphthalmologyUniversity of Tübingen, Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Ophthalmic Research, Centre for OphthalmologyUniversity of Tübingen, Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schon, Christian" sort="Schon, Christian" uniqKey="Schon C" first="Christian" last="Schön">Christian Schön</name>
<affiliation wicri:level="1"><nlm:aff id="Aff60"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 973X</institution-id>
<institution-id institution-id-type="GRID">grid.5252.0</institution-id>
<institution>Center for Integrated Protein Science Munich CiPSM at the Department of Pharmacy – Center for Drug Research,</institution>
<institution>Ludwig-Maximilians-Universität München,</institution>
</institution-wrap>
Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Munich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fischer, Dominik M" sort="Fischer, Dominik M" uniqKey="Fischer D" first="Dominik M." last="Fischer">Dominik M. Fischer</name>
<affiliation wicri:level="1"><nlm:aff id="Aff62"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>University Eye Hospital, Centre for Ophthalmology Tübingen,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wilhelm, Barbara" sort="Wilhelm, Barbara" uniqKey="Wilhelm B" first="Barbara" last="Wilhelm">Barbara Wilhelm</name>
<affiliation wicri:level="1"><nlm:aff id="Aff63"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>STZ eyetrial at the Centre for Ophthalmology,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zobor, Ditta" sort="Zobor, Ditta" uniqKey="Zobor D" first="Ditta" last="Zobor">Ditta Zobor</name>
<affiliation wicri:level="1"><nlm:aff id="Aff62"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>University Eye Hospital, Centre for Ophthalmology Tübingen,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kohl, Susanne" sort="Kohl, Susanne" uniqKey="Kohl S" first="Susanne" last="Kohl">Susanne Kohl</name>
<affiliation wicri:level="1"><nlm:aff id="Aff61">Institute for Ophthalmic Research, Centre for OphthalmologyUniversity of Tübingen, Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Ophthalmic Research, Centre for OphthalmologyUniversity of Tübingen, Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peters, Tobias" sort="Peters, Tobias" uniqKey="Peters T" first="Tobias" last="Peters">Tobias Peters</name>
<affiliation wicri:level="1"><nlm:aff id="Aff63"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>STZ eyetrial at the Centre for Ophthalmology,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zrenner, Eberhart" sort="Zrenner, Eberhart" uniqKey="Zrenner E" first="Eberhart" last="Zrenner">Eberhart Zrenner</name>
<affiliation wicri:level="1"><nlm:aff id="Aff61">Institute for Ophthalmic Research, Centre for OphthalmologyUniversity of Tübingen, Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Ophthalmic Research, Centre for OphthalmologyUniversity of Tübingen, Tübingen</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff62"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>University Eye Hospital, Centre for Ophthalmology Tübingen,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bartz Schmidt, Karl Ulrich" sort="Bartz Schmidt, Karl Ulrich" uniqKey="Bartz Schmidt K" first="Karl Ulrich" last="Bartz-Schmidt">Karl Ulrich Bartz-Schmidt</name>
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<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>University Eye Hospital, Centre for Ophthalmology Tübingen,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ueffing, Marius" sort="Ueffing, Marius" uniqKey="Ueffing M" first="Marius" last="Ueffing">Marius Ueffing</name>
<affiliation wicri:level="1"><nlm:aff id="Aff62"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>University Eye Hospital, Centre for Ophthalmology Tübingen,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wissinger, Bernd" sort="Wissinger, Bernd" uniqKey="Wissinger B" first="Bernd" last="Wissinger">Bernd Wissinger</name>
<affiliation wicri:level="1"><nlm:aff id="Aff62"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>University Eye Hospital, Centre for Ophthalmology Tübingen,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Seeliger, Mathias" sort="Seeliger, Mathias" uniqKey="Seeliger M" first="Mathias" last="Seeliger">Mathias Seeliger</name>
<affiliation wicri:level="1"><nlm:aff id="Aff62"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>University Eye Hospital, Centre for Ophthalmology Tübingen,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Biel, Martin" sort="Biel, Martin" uniqKey="Biel M" first="Martin" last="Biel">Martin Biel</name>
<affiliation wicri:level="1"><nlm:aff id="Aff60"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 973X</institution-id>
<institution-id institution-id-type="GRID">grid.5252.0</institution-id>
<institution>Center for Integrated Protein Science Munich CiPSM at the Department of Pharmacy – Center for Drug Research,</institution>
<institution>Ludwig-Maximilians-Universität München,</institution>
</institution-wrap>
Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Munich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ranek, Mark J" sort="Ranek, Mark J" uniqKey="Ranek M" first="Mark J." last="Ranek">Mark J. Ranek</name>
<affiliation wicri:level="2"><nlm:aff id="Aff64"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 9311</institution-id>
<institution-id institution-id-type="GRID">grid.21107.35</institution-id>
<institution>Division of Cardiology,</institution>
<institution>Johns Hopkins Medical Institutions,</institution>
</institution-wrap>
Baltimore, MD 21205 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kokkonen, Kristen M" sort="Kokkonen, Kristen M" uniqKey="Kokkonen K" first="Kristen M." last="Kokkonen">Kristen M. Kokkonen</name>
<affiliation wicri:level="2"><nlm:aff id="Aff64"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 9311</institution-id>
<institution-id institution-id-type="GRID">grid.21107.35</institution-id>
<institution>Division of Cardiology,</institution>
<institution>Johns Hopkins Medical Institutions,</institution>
</institution-wrap>
Baltimore, MD 21205 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lee, Dong I" sort="Lee, Dong I" uniqKey="Lee D" first="Dong I." last="Lee">Dong I. Lee</name>
<affiliation wicri:level="2"><nlm:aff id="Aff64"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 9311</institution-id>
<institution-id institution-id-type="GRID">grid.21107.35</institution-id>
<institution>Division of Cardiology,</institution>
<institution>Johns Hopkins Medical Institutions,</institution>
</institution-wrap>
Baltimore, MD 21205 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Holewinski, Ronald J" sort="Holewinski, Ronald J" uniqKey="Holewinski R" first="Ronald J." last="Holewinski">Ronald J. Holewinski</name>
<affiliation wicri:level="2"><nlm:aff id="Aff65">Heart Institute and Advanced Clinical Biosystems Research Institute, Cedar Sinai Medical Center, 8700 Beverly Blvd, AHSP A9229, Los Angeles, California 90048 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Heart Institute and Advanced Clinical Biosystems Research Institute, Cedar Sinai Medical Center, 8700 Beverly Blvd, AHSP A9229, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Agrawal, Vineet" sort="Agrawal, Vineet" uniqKey="Agrawal V" first="Vineet" last="Agrawal">Vineet Agrawal</name>
<affiliation wicri:level="2"><nlm:aff id="Aff64"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 9311</institution-id>
<institution-id institution-id-type="GRID">grid.21107.35</institution-id>
<institution>Division of Cardiology,</institution>
<institution>Johns Hopkins Medical Institutions,</institution>
</institution-wrap>
Baltimore, MD 21205 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Virus, Cornelia" sort="Virus, Cornelia" uniqKey="Virus C" first="Cornelia" last="Virus">Cornelia Virus</name>
<affiliation wicri:level="2"><nlm:aff id="Aff66"><institution-wrap><institution-id institution-id-type="ISNI">0000000122483208</institution-id>
<institution-id institution-id-type="GRID">grid.10698.36</institution-id>
<institution>McAllister Heart Institute, Division of Cardiology, UNC,</institution>
</institution-wrap>
Chapel Hill, NC USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Chapel Hill</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Stevens, Donte A" sort="Stevens, Donte A" uniqKey="Stevens D" first="Donté A." last="Stevens">Donté A. Stevens</name>
<affiliation wicri:level="2"><nlm:aff id="Aff66"><institution-wrap><institution-id institution-id-type="ISNI">0000000122483208</institution-id>
<institution-id institution-id-type="GRID">grid.10698.36</institution-id>
<institution>McAllister Heart Institute, Division of Cardiology, UNC,</institution>
</institution-wrap>
Chapel Hill, NC USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Chapel Hill</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sasaki, Masayuki" sort="Sasaki, Masayuki" uniqKey="Sasaki M" first="Masayuki" last="Sasaki">Masayuki Sasaki</name>
<affiliation wicri:level="2"><nlm:aff id="Aff64"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 9311</institution-id>
<institution-id institution-id-type="GRID">grid.21107.35</institution-id>
<institution>Division of Cardiology,</institution>
<institution>Johns Hopkins Medical Institutions,</institution>
</institution-wrap>
Baltimore, MD 21205 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zhang, Huaqun" sort="Zhang, Huaqun" uniqKey="Zhang H" first="Huaqun" last="Zhang">Huaqun Zhang</name>
<affiliation wicri:level="2"><nlm:aff id="Aff67"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2195 6763</institution-id>
<institution-id institution-id-type="GRID">grid.259956.4</institution-id>
<institution>Department of Chemistry and Biochemistry,</institution>
<institution>Miami University,</institution>
</institution-wrap>
Oxford, OH 45056 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Oxford</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mannion, Mathew M" sort="Mannion, Mathew M" uniqKey="Mannion M" first="Mathew M." last="Mannion">Mathew M. Mannion</name>
<affiliation wicri:level="2"><nlm:aff id="Aff67"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2195 6763</institution-id>
<institution-id institution-id-type="GRID">grid.259956.4</institution-id>
<institution>Department of Chemistry and Biochemistry,</institution>
<institution>Miami University,</institution>
</institution-wrap>
Oxford, OH 45056 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Oxford</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rainer, Peter P" sort="Rainer, Peter P" uniqKey="Rainer P" first="Peter P." last="Rainer">Peter P. Rainer</name>
<affiliation wicri:level="2"><nlm:aff id="Aff64"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 9311</institution-id>
<institution-id institution-id-type="GRID">grid.21107.35</institution-id>
<institution>Division of Cardiology,</institution>
<institution>Johns Hopkins Medical Institutions,</institution>
</institution-wrap>
Baltimore, MD 21205 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Page, Richard C" sort="Page, Richard C" uniqKey="Page R" first="Richard C." last="Page">Richard C. Page</name>
<affiliation wicri:level="2"><nlm:aff id="Aff67"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2195 6763</institution-id>
<institution-id institution-id-type="GRID">grid.259956.4</institution-id>
<institution>Department of Chemistry and Biochemistry,</institution>
<institution>Miami University,</institution>
</institution-wrap>
Oxford, OH 45056 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Oxford</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Schisler, Jonathan C" sort="Schisler, Jonathan C" uniqKey="Schisler J" first="Jonathan C." last="Schisler">Jonathan C. Schisler</name>
<affiliation wicri:level="2"><nlm:aff id="Aff66"><institution-wrap><institution-id institution-id-type="ISNI">0000000122483208</institution-id>
<institution-id institution-id-type="GRID">grid.10698.36</institution-id>
<institution>McAllister Heart Institute, Division of Cardiology, UNC,</institution>
</institution-wrap>
Chapel Hill, NC USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Chapel Hill</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Van Eyk, Jennifer E" sort="Van Eyk, Jennifer E" uniqKey="Van Eyk J" first="Jennifer E." last="Van Eyk">Jennifer E. Van Eyk</name>
<affiliation wicri:level="2"><nlm:aff id="Aff65">Heart Institute and Advanced Clinical Biosystems Research Institute, Cedar Sinai Medical Center, 8700 Beverly Blvd, AHSP A9229, Los Angeles, California 90048 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Heart Institute and Advanced Clinical Biosystems Research Institute, Cedar Sinai Medical Center, 8700 Beverly Blvd, AHSP A9229, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Willis, Monte S" sort="Willis, Monte S" uniqKey="Willis M" first="Monte S." last="Willis">Monte S. Willis</name>
<affiliation wicri:level="2"><nlm:aff id="Aff66"><institution-wrap><institution-id institution-id-type="ISNI">0000000122483208</institution-id>
<institution-id institution-id-type="GRID">grid.10698.36</institution-id>
<institution>McAllister Heart Institute, Division of Cardiology, UNC,</institution>
</institution-wrap>
Chapel Hill, NC USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Chapel Hill</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kass, David A" sort="Kass, David A" uniqKey="Kass D" first="David A." last="Kass">David A. Kass</name>
<affiliation wicri:level="2"><nlm:aff id="Aff64"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 9311</institution-id>
<institution-id institution-id-type="GRID">grid.21107.35</institution-id>
<institution>Division of Cardiology,</institution>
<institution>Johns Hopkins Medical Institutions,</institution>
</institution-wrap>
Baltimore, MD 21205 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zaccolo, Manuela" sort="Zaccolo, Manuela" uniqKey="Zaccolo M" first="Manuela" last="Zaccolo">Manuela Zaccolo</name>
<affiliation wicri:level="1"><nlm:aff id="Aff68">Department of Pyhisology, Anatomy and GeneticsUniversity of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Pyhisology, Anatomy and GeneticsUniversity of Oxford, Oxford</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Russwurm, Michael" sort="Russwurm, Michael" uniqKey="Russwurm M" first="Michael" last="Russwurm">Michael Russwurm</name>
<affiliation wicri:level="1"><nlm:aff id="Aff69"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Institute for Pharmacology and Toxicology, Medical Faculty,</institution>
<institution>Ruhr-University Bochum,</institution>
</institution-wrap>
44780 Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>44780 Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Giesen, Jan" sort="Giesen, Jan" uniqKey="Giesen J" first="Jan" last="Giesen">Jan Giesen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff69"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Institute for Pharmacology and Toxicology, Medical Faculty,</institution>
<institution>Ruhr-University Bochum,</institution>
</institution-wrap>
44780 Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>44780 Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Russwurm, Corina" sort="Russwurm, Corina" uniqKey="Russwurm C" first="Corina" last="Russwurm">Corina Russwurm</name>
<affiliation wicri:level="1"><nlm:aff id="Aff69"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Institute for Pharmacology and Toxicology, Medical Faculty,</institution>
<institution>Ruhr-University Bochum,</institution>
</institution-wrap>
44780 Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>44780 Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fuchtbauer, Ernst Martin" sort="Fuchtbauer, Ernst Martin" uniqKey="Fuchtbauer E" first="Ernst-Martin" last="Füchtbauer">Ernst-Martin Füchtbauer</name>
<affiliation wicri:level="1"><nlm:aff id="Aff70"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1956 2722</institution-id>
<institution-id institution-id-type="GRID">grid.7048.b</institution-id>
<institution>Department of Molecular Biology and Genetics - Molecular Cell and Developmental Biology,</institution>
<institution>Aarhus University,</institution>
</institution-wrap>
C.F. Møllers Allé 3, 8000 Aarhus C, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>C.F. Møllers Allé 3, 8000 Aarhus C</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koesling, Doris" sort="Koesling, Doris" uniqKey="Koesling D" first="Doris" last="Koesling">Doris Koesling</name>
<affiliation wicri:level="1"><nlm:aff id="Aff69"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Institute for Pharmacology and Toxicology, Medical Faculty,</institution>
<institution>Ruhr-University Bochum,</institution>
</institution-wrap>
44780 Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>44780 Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bork, Nadja I" sort="Bork, Nadja I" uniqKey="Bork N" first="Nadja I." last="Bork">Nadja I. Bork</name>
<affiliation wicri:level="1"><nlm:aff id="Aff71"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Institute of Experimental Cardiovascular Research, Center for Experimental Medicine,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nikolaev, Viacheslav O" sort="Nikolaev, Viacheslav O" uniqKey="Nikolaev V" first="Viacheslav O." last="Nikolaev">Viacheslav O. Nikolaev</name>
<affiliation wicri:level="1"><nlm:aff id="Aff71"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Institute of Experimental Cardiovascular Research, Center for Experimental Medicine,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Agull, Luis" sort="Agull, Luis" uniqKey="Agull L" first="Luis" last="Agull">Luis Agull</name>
<affiliation><nlm:aff id="Aff72"><institution-wrap><institution-id institution-id-type="GRID">grid.440820.a</institution-id>
<institution>Computational Biochemistry and Biophysics Laboratory (CBBL), U_ScienceTech (UST),</institution>
<institution>University of Vic - Central University of Catalonia (UVIC-UCC),</institution>
</institution-wrap>
Vic, Barcelona Spain</nlm:aff>
<wicri:noCountry code="subfield">Barcelona Spain</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Floor, Martin" sort="Floor, Martin" uniqKey="Floor M" first="Martin" last="Floor">Martin Floor</name>
<affiliation><nlm:aff id="Aff72"><institution-wrap><institution-id institution-id-type="GRID">grid.440820.a</institution-id>
<institution>Computational Biochemistry and Biophysics Laboratory (CBBL), U_ScienceTech (UST),</institution>
<institution>University of Vic - Central University of Catalonia (UVIC-UCC),</institution>
</institution-wrap>
Vic, Barcelona Spain</nlm:aff>
<wicri:noCountry code="subfield">Barcelona Spain</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Villa Freixa, Jordi" sort="Villa Freixa, Jordi" uniqKey="Villa Freixa J" first="Jordi" last="Villà-Freixa">Jordi Villà-Freixa</name>
<affiliation><nlm:aff id="Aff72"><institution-wrap><institution-id institution-id-type="GRID">grid.440820.a</institution-id>
<institution>Computational Biochemistry and Biophysics Laboratory (CBBL), U_ScienceTech (UST),</institution>
<institution>University of Vic - Central University of Catalonia (UVIC-UCC),</institution>
</institution-wrap>
Vic, Barcelona Spain</nlm:aff>
<wicri:noCountry code="subfield">Barcelona Spain</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Manfra, Ornella" sort="Manfra, Ornella" uniqKey="Manfra O" first="Ornella" last="Manfra">Ornella Manfra</name>
<affiliation wicri:level="1"><nlm:aff id="Aff73"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff74"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Calamera, Gaia" sort="Calamera, Gaia" uniqKey="Calamera G" first="Gaia" last="Calamera">Gaia Calamera</name>
<affiliation wicri:level="1"><nlm:aff id="Aff73"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff74"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Surdo, Nicoletta C" sort="Surdo, Nicoletta C" uniqKey="Surdo N" first="Nicoletta C." last="Surdo">Nicoletta C. Surdo</name>
<affiliation wicri:level="1"><nlm:aff id="Aff75"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Department of Physiology, Anatomy and Genetics,</institution>
<institution>Oxford University,</institution>
</institution-wrap>
Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meier, Silja" sort="Meier, Silja" uniqKey="Meier S" first="Silja" last="Meier">Silja Meier</name>
<affiliation wicri:level="1"><nlm:aff id="Aff73"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff74"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Froese, Alexander" sort="Froese, Alexander" uniqKey="Froese A" first="Alexander" last="Froese">Alexander Froese</name>
<affiliation wicri:level="1"><nlm:aff id="Aff76"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>German Center for Cardiovascular Research,</institution>
<institution>University Medical Center Hamburg-Eppendorf and Institute of Experimental Cardiovascular Research,</institution>
</institution-wrap>
Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nikolaev, Viacheslav O" sort="Nikolaev, Viacheslav O" uniqKey="Nikolaev V" first="Viacheslav O." last="Nikolaev">Viacheslav O. Nikolaev</name>
<affiliation wicri:level="1"><nlm:aff id="Aff76"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>German Center for Cardiovascular Research,</institution>
<institution>University Medical Center Hamburg-Eppendorf and Institute of Experimental Cardiovascular Research,</institution>
</institution-wrap>
Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zaccolo, Manuela" sort="Zaccolo, Manuela" uniqKey="Zaccolo M" first="Manuela" last="Zaccolo">Manuela Zaccolo</name>
<affiliation wicri:level="1"><nlm:aff id="Aff75"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Department of Physiology, Anatomy and Genetics,</institution>
<institution>Oxford University,</institution>
</institution-wrap>
Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Levy, Finn Olav" sort="Levy, Finn Olav" uniqKey="Levy F" first="Finn Olav" last="Levy">Finn Olav Levy</name>
<affiliation wicri:level="1"><nlm:aff id="Aff73"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff74"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Andressen, Kjetil Wessel" sort="Andressen, Kjetil Wessel" uniqKey="Andressen K" first="Kjetil Wessel" last="Andressen">Kjetil Wessel Andressen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff73"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff74"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aue, Annemarie" sort="Aue, Annemarie" uniqKey="Aue A" first="Annemarie" last="Aue">Annemarie Aue</name>
<affiliation wicri:level="1"><nlm:aff id="Aff77"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schwiering, Fabian" sort="Schwiering, Fabian" uniqKey="Schwiering F" first="Fabian" last="Schwiering">Fabian Schwiering</name>
<affiliation wicri:level="1"><nlm:aff id="Aff77"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Groneberg, Dieter" sort="Groneberg, Dieter" uniqKey="Groneberg D" first="Dieter" last="Groneberg">Dieter Groneberg</name>
<affiliation wicri:level="1"><nlm:aff id="Aff77"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Friebe, Andreas" sort="Friebe, Andreas" uniqKey="Friebe A" first="Andreas" last="Friebe">Andreas Friebe</name>
<affiliation wicri:level="1"><nlm:aff id="Aff77"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bajraktari, Gzona" sort="Bajraktari, Gzona" uniqKey="Bajraktari G" first="Gzona" last="Bajraktari">Gzona Bajraktari</name>
<affiliation wicri:level="1"><nlm:aff id="Aff78"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 4373</institution-id>
<institution-id institution-id-type="GRID">grid.7700.0</institution-id>
<institution>Department of Clinical Pharmacology and Pharmacoepidemiology,</institution>
<institution>University of Heidelberg,</institution>
</institution-wrap>
Im Neuenheimer Feld 410, 69120 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Im Neuenheimer Feld 410, 69120 Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Burhenne, Jurgen" sort="Burhenne, Jurgen" uniqKey="Burhenne J" first="Jürgen" last="Burhenne">Jürgen Burhenne</name>
<affiliation wicri:level="1"><nlm:aff id="Aff78"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 4373</institution-id>
<institution-id institution-id-type="GRID">grid.7700.0</institution-id>
<institution>Department of Clinical Pharmacology and Pharmacoepidemiology,</institution>
<institution>University of Heidelberg,</institution>
</institution-wrap>
Im Neuenheimer Feld 410, 69120 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Im Neuenheimer Feld 410, 69120 Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haefeli, Walter E" sort="Haefeli, Walter E" uniqKey="Haefeli W" first="Walter E." last="Haefeli">Walter E. Haefeli</name>
<affiliation wicri:level="1"><nlm:aff id="Aff78"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 4373</institution-id>
<institution-id institution-id-type="GRID">grid.7700.0</institution-id>
<institution>Department of Clinical Pharmacology and Pharmacoepidemiology,</institution>
<institution>University of Heidelberg,</institution>
</institution-wrap>
Im Neuenheimer Feld 410, 69120 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Im Neuenheimer Feld 410, 69120 Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Weiss, Johanna" sort="Weiss, Johanna" uniqKey="Weiss J" first="Johanna" last="Weiss">Johanna Weiss</name>
<affiliation wicri:level="1"><nlm:aff id="Aff78"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 4373</institution-id>
<institution-id institution-id-type="GRID">grid.7700.0</institution-id>
<institution>Department of Clinical Pharmacology and Pharmacoepidemiology,</institution>
<institution>University of Heidelberg,</institution>
</institution-wrap>
Im Neuenheimer Feld 410, 69120 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Im Neuenheimer Feld 410, 69120 Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Beck, Katharina" sort="Beck, Katharina" uniqKey="Beck K" first="Katharina" last="Beck">Katharina Beck</name>
<affiliation wicri:level="1"><nlm:aff id="Aff79"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Voussen, Barbara" sort="Voussen, Barbara" uniqKey="Voussen B" first="Barbara" last="Voussen">Barbara Voussen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff79"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vincent, Alexander" sort="Vincent, Alexander" uniqKey="Vincent A" first="Alexander" last="Vincent">Alexander Vincent</name>
<affiliation wicri:level="1"><nlm:aff id="Aff80"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8227</institution-id>
<institution-id institution-id-type="GRID">grid.25073.33</institution-id>
<institution>Farncombe Family Digestive Health Research Institute,</institution>
<institution>McMaster University,</institution>
</institution-wrap>
Hamilton, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Hamilton</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Parsons, Sean P" sort="Parsons, Sean P" uniqKey="Parsons S" first="Sean P." last="Parsons">Sean P. Parsons</name>
<affiliation wicri:level="1"><nlm:aff id="Aff80"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8227</institution-id>
<institution-id institution-id-type="GRID">grid.25073.33</institution-id>
<institution>Farncombe Family Digestive Health Research Institute,</institution>
<institution>McMaster University,</institution>
</institution-wrap>
Hamilton, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Hamilton</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huizinga, Jan D" sort="Huizinga, Jan D" uniqKey="Huizinga J" first="Jan D." last="Huizinga">Jan D. Huizinga</name>
<affiliation wicri:level="1"><nlm:aff id="Aff80"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8227</institution-id>
<institution-id institution-id-type="GRID">grid.25073.33</institution-id>
<institution>Farncombe Family Digestive Health Research Institute,</institution>
<institution>McMaster University,</institution>
</institution-wrap>
Hamilton, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Hamilton</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Friebe, Andreas" sort="Friebe, Andreas" uniqKey="Friebe A" first="Andreas" last="Friebe">Andreas Friebe</name>
<affiliation wicri:level="1"><nlm:aff id="Aff79"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="M Nica, Fabiola Zakia" sort="M Nica, Fabiola Zakia" uniqKey="M Nica F" first="Fabiola Zakia" last="M Nica">Fabiola Zakia M Nica</name>
<affiliation wicri:level="2"><nlm:aff id="Aff81"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9510</institution-id>
<institution-id institution-id-type="GRID">grid.253615.6</institution-id>
<institution>Department of Biochemistry and Molecular Medicine,</institution>
<institution>George Washington University, School of Medicine,</institution>
</institution-wrap>
Washington, DC USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">District de Columbia</region>
</placeName>
<wicri:cityArea>Washington</wicri:cityArea>
</affiliation>
<affiliation><nlm:aff id="Aff82"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0723 2494</institution-id>
<institution-id institution-id-type="GRID">grid.411087.b</institution-id>
<institution>Department of Pharmacology, Faculty of Medical Sciences,</institution>
<institution>State University of Campinas (UNICAMP),</institution>
</institution-wrap>
Campinas, Sao Paolo Brazil</nlm:aff>
<wicri:noCountry code="subfield">Sao Paolo Brazil</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Seto, Edward" sort="Seto, Edward" uniqKey="Seto E" first="Edward" last="Seto">Edward Seto</name>
<affiliation wicri:level="2"><nlm:aff id="Aff81"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9510</institution-id>
<institution-id institution-id-type="GRID">grid.253615.6</institution-id>
<institution>Department of Biochemistry and Molecular Medicine,</institution>
<institution>George Washington University, School of Medicine,</institution>
</institution-wrap>
Washington, DC USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">District de Columbia</region>
</placeName>
<wicri:cityArea>Washington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Murad, Ferid" sort="Murad, Ferid" uniqKey="Murad F" first="Ferid" last="Murad">Ferid Murad</name>
<affiliation wicri:level="2"><nlm:aff id="Aff81"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9510</institution-id>
<institution-id institution-id-type="GRID">grid.253615.6</institution-id>
<institution>Department of Biochemistry and Molecular Medicine,</institution>
<institution>George Washington University, School of Medicine,</institution>
</institution-wrap>
Washington, DC USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">District de Columbia</region>
</placeName>
<wicri:cityArea>Washington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bian, Ka" sort="Bian, Ka" uniqKey="Bian K" first="Ka" last="Bian">Ka Bian</name>
<affiliation wicri:level="2"><nlm:aff id="Aff81"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9510</institution-id>
<institution-id institution-id-type="GRID">grid.253615.6</institution-id>
<institution>Department of Biochemistry and Molecular Medicine,</institution>
<institution>George Washington University, School of Medicine,</institution>
</institution-wrap>
Washington, DC USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">District de Columbia</region>
</placeName>
<wicri:cityArea>Washington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Burgoyne, Joseph R" sort="Burgoyne, Joseph R" uniqKey="Burgoyne J" first="Joseph R." last="Burgoyne">Joseph R. Burgoyne</name>
<affiliation><nlm:aff id="Aff83"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>King’s College London, Cardiovascular Division, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas’ Hospital,</institution>
</institution-wrap>
London, SE1 7EH UK</nlm:aff>
<wicri:noCountry code="subfield">SE1 7EH UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Prysyazhna, Oleksandra" sort="Prysyazhna, Oleksandra" uniqKey="Prysyazhna O" first="Oleksandra" last="Prysyazhna">Oleksandra Prysyazhna</name>
<affiliation><nlm:aff id="Aff83"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>King’s College London, Cardiovascular Division, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas’ Hospital,</institution>
</institution-wrap>
London, SE1 7EH UK</nlm:aff>
<wicri:noCountry code="subfield">SE1 7EH UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Richards, Daniel" sort="Richards, Daniel" uniqKey="Richards D" first="Daniel" last="Richards">Daniel Richards</name>
<affiliation><nlm:aff id="Aff83"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>King’s College London, Cardiovascular Division, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas’ Hospital,</institution>
</institution-wrap>
London, SE1 7EH UK</nlm:aff>
<wicri:noCountry code="subfield">SE1 7EH UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Eaton, Philip" sort="Eaton, Philip" uniqKey="Eaton P" first="Philip" last="Eaton">Philip Eaton</name>
<affiliation><nlm:aff id="Aff83"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>King’s College London, Cardiovascular Division, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas’ Hospital,</institution>
</institution-wrap>
London, SE1 7EH UK</nlm:aff>
<wicri:noCountry code="subfield">SE1 7EH UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Calamera, Gaia" sort="Calamera, Gaia" uniqKey="Calamera G" first="Gaia" last="Calamera">Gaia Calamera</name>
<affiliation wicri:level="1"><nlm:aff id="Aff84"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff85"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bj Rnerem, Marianne" sort="Bj Rnerem, Marianne" uniqKey="Bj Rnerem M" first="Marianne" last="Bj Rnerem">Marianne Bj Rnerem</name>
<affiliation wicri:level="1"><nlm:aff id="Aff84"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff85"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ulsund, Andrea Hembre" sort="Ulsund, Andrea Hembre" uniqKey="Ulsund A" first="Andrea Hembre" last="Ulsund">Andrea Hembre Ulsund</name>
<affiliation wicri:level="1"><nlm:aff id="Aff84"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff85"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kim, Jeong Joo" sort="Kim, Jeong Joo" uniqKey="Kim J" first="Jeong Joo" last="Kim">Jeong Joo Kim</name>
<affiliation><nlm:aff id="Aff86"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, Texas USA</nlm:aff>
<wicri:noCountry code="subfield">Texas USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kim, Choel" sort="Kim, Choel" uniqKey="Kim C" first="Choel" last="Kim">Choel Kim</name>
<affiliation><nlm:aff id="Aff86"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, Texas USA</nlm:aff>
<wicri:noCountry code="subfield">Texas USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Levy, Finn Olav" sort="Levy, Finn Olav" uniqKey="Levy F" first="Finn Olav" last="Levy">Finn Olav Levy</name>
<affiliation wicri:level="1"><nlm:aff id="Aff84"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff85"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Andressen, Kjetil Wessel" sort="Andressen, Kjetil Wessel" uniqKey="Andressen K" first="Kjetil Wessel" last="Andressen">Kjetil Wessel Andressen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff84"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff85"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Donzelli, Sonia" sort="Donzelli, Sonia" uniqKey="Donzelli S" first="Sonia" last="Donzelli">Sonia Donzelli</name>
<affiliation wicri:level="1"><nlm:aff id="Aff87"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center,</institution>
<institution>University, Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff88"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Goetz, Mara" sort="Goetz, Mara" uniqKey="Goetz M" first="Mara" last="Goetz">Mara Goetz</name>
<affiliation wicri:level="1"><nlm:aff id="Aff87"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center,</institution>
<institution>University, Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff88"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmidt, Kjestine" sort="Schmidt, Kjestine" uniqKey="Schmidt K" first="Kjestine" last="Schmidt">Kjestine Schmidt</name>
<affiliation wicri:level="1"><nlm:aff id="Aff88"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff89"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0057 2672</institution-id>
<institution-id institution-id-type="GRID">grid.4562.5</institution-id>
<institution>Department of Physiology,</institution>
<institution>University of Lübeck, DZHK Partner Site Hamburg/Kiel/Lübeck, University Heart Centre Lübeck,</institution>
</institution-wrap>
Lübeck, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Lübeck</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wolters, Markus" sort="Wolters, Markus" uniqKey="Wolters M" first="Markus" last="Wolters">Markus Wolters</name>
<affiliation wicri:level="1"><nlm:aff id="Aff90"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Hoppe-Seyler-Str. 4, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hoppe-Seyler-Str. 4, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stathopoulou, Konstantina" sort="Stathopoulou, Konstantina" uniqKey="Stathopoulou K" first="Konstantina" last="Stathopoulou">Konstantina Stathopoulou</name>
<affiliation wicri:level="1"><nlm:aff id="Aff87"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center,</institution>
<institution>University, Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff88"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Prysyazhna, Oleksandra" sort="Prysyazhna, Oleksandra" uniqKey="Prysyazhna O" first="Oleksandra" last="Prysyazhna">Oleksandra Prysyazhna</name>
<affiliation wicri:level="1"><nlm:aff id="Aff91"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>King’s College London, Cardiovascular Division, British Heart Foundation Centre of Excellence,</institution>
<institution>the Rayne Institute, St Thomas´ Hospital,</institution>
</institution-wrap>
SE17EH, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>SE17EH, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Scotcher, Jenna" sort="Scotcher, Jenna" uniqKey="Scotcher J" first="Jenna" last="Scotcher">Jenna Scotcher</name>
<affiliation wicri:level="1"><nlm:aff id="Aff91"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>King’s College London, Cardiovascular Division, British Heart Foundation Centre of Excellence,</institution>
<institution>the Rayne Institute, St Thomas´ Hospital,</institution>
</institution-wrap>
SE17EH, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>SE17EH, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dees, Christian" sort="Dees, Christian" uniqKey="Dees C" first="Christian" last="Dees">Christian Dees</name>
<affiliation wicri:level="1"><nlm:aff id="Aff92">Institute of Experimental Biomedicine II, University Medical Center Würzburg, Grombühlstraße 12, 97080 Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Experimental Biomedicine II, University Medical Center Würzburg, Grombühlstraße 12, 97080 Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Subramanian, Hariharan" sort="Subramanian, Hariharan" uniqKey="Subramanian H" first="Hariharan" last="Subramanian">Hariharan Subramanian</name>
<affiliation wicri:level="1"><nlm:aff id="Aff88"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff93"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Institute of Experimental Cardiovascular Research,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Butt, Elke" sort="Butt, Elke" uniqKey="Butt E" first="Elke" last="Butt">Elke Butt</name>
<affiliation wicri:level="1"><nlm:aff id="Aff92">Institute of Experimental Biomedicine II, University Medical Center Würzburg, Grombühlstraße 12, 97080 Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Experimental Biomedicine II, University Medical Center Würzburg, Grombühlstraße 12, 97080 Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kamynina, Alisa" sort="Kamynina, Alisa" uniqKey="Kamynina A" first="Alisa" last="Kamynina">Alisa Kamynina</name>
<affiliation wicri:level="1"><nlm:aff id="Aff91"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>King’s College London, Cardiovascular Division, British Heart Foundation Centre of Excellence,</institution>
<institution>the Rayne Institute, St Thomas´ Hospital,</institution>
</institution-wrap>
SE17EH, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>SE17EH, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bruce King, S" sort="Bruce King, S" uniqKey="Bruce King S" first="S." last="Bruce King">S. Bruce King</name>
<affiliation wicri:level="2"><nlm:aff id="Aff94"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2185 3318</institution-id>
<institution-id institution-id-type="GRID">grid.241167.7</institution-id>
<institution>Department of Chemistry,</institution>
<institution>Wake Forest University,</institution>
</institution-wrap>
Winston-Salem, North Carolina 27109 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Winston-Salem</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Nikolaev, Viacheslav O" sort="Nikolaev, Viacheslav O" uniqKey="Nikolaev V" first="Viacheslav O." last="Nikolaev">Viacheslav O. Nikolaev</name>
<affiliation wicri:level="1"><nlm:aff id="Aff88"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff93"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Institute of Experimental Cardiovascular Research,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Witt, Cor" sort="De Witt, Cor" uniqKey="De Witt C" first="Cor" last="De Witt">Cor De Witt</name>
<affiliation wicri:level="1"><nlm:aff id="Aff88"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff89"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0057 2672</institution-id>
<institution-id institution-id-type="GRID">grid.4562.5</institution-id>
<institution>Department of Physiology,</institution>
<institution>University of Lübeck, DZHK Partner Site Hamburg/Kiel/Lübeck, University Heart Centre Lübeck,</institution>
</institution-wrap>
Lübeck, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Lübeck</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Leichert, Lars I" sort="Leichert, Lars I" uniqKey="Leichert L" first="Lars I." last="Leichert">Lars I. Leichert</name>
<affiliation wicri:level="1"><nlm:aff id="Aff95"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Institute of Biochemistry and Pathobiochemistry - Microbial Biochemistry,</institution>
<institution>Ruhr University Bochum,</institution>
</institution-wrap>
Universitätsstrasse 150, 44780 Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Universitätsstrasse 150, 44780 Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Feil, Robert" sort="Feil, Robert" uniqKey="Feil R" first="Robert" last="Feil">Robert Feil</name>
<affiliation wicri:level="1"><nlm:aff id="Aff90"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Hoppe-Seyler-Str. 4, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hoppe-Seyler-Str. 4, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eaton, Philip" sort="Eaton, Philip" uniqKey="Eaton P" first="Philip" last="Eaton">Philip Eaton</name>
<affiliation wicri:level="1"><nlm:aff id="Aff91"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>King’s College London, Cardiovascular Division, British Heart Foundation Centre of Excellence,</institution>
<institution>the Rayne Institute, St Thomas´ Hospital,</institution>
</institution-wrap>
SE17EH, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>SE17EH, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cuello, Friederike" sort="Cuello, Friederike" uniqKey="Cuello F" first="Friederike" last="Cuello">Friederike Cuello</name>
<affiliation wicri:level="1"><nlm:aff id="Aff87"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center,</institution>
<institution>University, Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff88"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dobrowinski, Hyazinth" sort="Dobrowinski, Hyazinth" uniqKey="Dobrowinski H" first="Hyazinth" last="Dobrowinski">Hyazinth Dobrowinski</name>
<affiliation wicri:level="1"><nlm:aff id="Aff96"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lehners, Moritz" sort="Lehners, Moritz" uniqKey="Lehners M" first="Moritz" last="Lehners">Moritz Lehners</name>
<affiliation wicri:level="1"><nlm:aff id="Aff96"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmidt, Michael Paolillo Hannes" sort="Schmidt, Michael Paolillo Hannes" uniqKey="Schmidt M" first="Michael Paolillo Hannes" last="Schmidt">Michael Paolillo Hannes Schmidt</name>
<affiliation wicri:level="1"><nlm:aff id="Aff96"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Feil, Robert" sort="Feil, Robert" uniqKey="Feil R" first="Robert" last="Feil">Robert Feil</name>
<affiliation wicri:level="1"><nlm:aff id="Aff96"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Feil, Susanne" sort="Feil, Susanne" uniqKey="Feil S" first="Susanne" last="Feil">Susanne Feil</name>
<affiliation wicri:level="1"><nlm:aff id="Aff97"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>Universität Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wen, Lai" sort="Wen, Lai" uniqKey="Wen L" first="Lai" last="Wen">Lai Wen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff97"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>Universität Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wolters, Markus" sort="Wolters, Markus" uniqKey="Wolters M" first="Markus" last="Wolters">Markus Wolters</name>
<affiliation wicri:level="1"><nlm:aff id="Aff97"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>Universität Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thunemann, Martin" sort="Thunemann, Martin" uniqKey="Thunemann M" first="Martin" last="Thunemann">Martin Thunemann</name>
<affiliation wicri:level="1"><nlm:aff id="Aff97"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>Universität Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmidt, Kjestine" sort="Schmidt, Kjestine" uniqKey="Schmidt K" first="Kjestine" last="Schmidt">Kjestine Schmidt</name>
<affiliation wicri:level="1"><nlm:aff id="Aff98"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0057 2672</institution-id>
<institution-id institution-id-type="GRID">grid.4562.5</institution-id>
<institution>Institut für Physiologie,</institution>
<institution>Universität zu Lübeck,</institution>
</institution-wrap>
Lübeck, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Lübeck</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Olbrich, Marcus" sort="Olbrich, Marcus" uniqKey="Olbrich M" first="Marcus" last="Olbrich">Marcus Olbrich</name>
<affiliation wicri:level="1"><nlm:aff id="Aff99"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Cardiology & Cardiovascular Medicine,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Langer, Harald" sort="Langer, Harald" uniqKey="Langer H" first="Harald" last="Langer">Harald Langer</name>
<affiliation wicri:level="1"><nlm:aff id="Aff99"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Cardiology & Cardiovascular Medicine,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gawaz, Meinrad" sort="Gawaz, Meinrad" uniqKey="Gawaz M" first="Meinrad" last="Gawaz">Meinrad Gawaz</name>
<affiliation wicri:level="1"><nlm:aff id="Aff99"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Cardiology & Cardiovascular Medicine,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Friebe, Andreas" sort="Friebe, Andreas" uniqKey="Friebe A" first="Andreas" last="Friebe">Andreas Friebe</name>
<affiliation wicri:level="1"><nlm:aff id="Aff100"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Wit, Cor" sort="De Wit, Cor" uniqKey="De Wit C" first="Cor" last="De Wit">Cor De Wit</name>
<affiliation wicri:level="1"><nlm:aff id="Aff98"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0057 2672</institution-id>
<institution-id institution-id-type="GRID">grid.4562.5</institution-id>
<institution>Institut für Physiologie,</institution>
<institution>Universität zu Lübeck,</institution>
</institution-wrap>
Lübeck, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Lübeck</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Feil, Robert" sort="Feil, Robert" uniqKey="Feil R" first="Robert" last="Feil">Robert Feil</name>
<affiliation wicri:level="1"><nlm:aff id="Aff97"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>Universität Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Franz, Eugen" sort="Franz, Eugen" uniqKey="Franz E" first="Eugen" last="Franz">Eugen Franz</name>
<affiliation wicri:level="1"><nlm:aff id="Aff101"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1089 1036</institution-id>
<institution-id institution-id-type="GRID">grid.5155.4</institution-id>
<institution>Department of Biochemistry,</institution>
<institution>University of Kassel,</institution>
</institution-wrap>
34132 Kassel, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>34132 Kassel</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kim, Jeong Joo" sort="Kim, Jeong Joo" uniqKey="Kim J" first="Jeong Joo" last="Kim">Jeong Joo Kim</name>
<affiliation wicri:level="1"><nlm:aff id="Aff101"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1089 1036</institution-id>
<institution-id institution-id-type="GRID">grid.5155.4</institution-id>
<institution>Department of Biochemistry,</institution>
<institution>University of Kassel,</institution>
</institution-wrap>
34132 Kassel, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>34132 Kassel</wicri:regionArea>
</affiliation>
<affiliation><nlm:aff id="Aff102"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
One Baylor Plaza, Houston, Texas USA</nlm:aff>
<wicri:noCountry code="subfield">Texas USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bertinetti, Daniela" sort="Bertinetti, Daniela" uniqKey="Bertinetti D" first="Daniela" last="Bertinetti">Daniela Bertinetti</name>
<affiliation wicri:level="1"><nlm:aff id="Aff101"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1089 1036</institution-id>
<institution-id institution-id-type="GRID">grid.5155.4</institution-id>
<institution>Department of Biochemistry,</institution>
<institution>University of Kassel,</institution>
</institution-wrap>
34132 Kassel, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>34132 Kassel</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kim, Choel" sort="Kim, Choel" uniqKey="Kim C" first="Choel" last="Kim">Choel Kim</name>
<affiliation><nlm:aff id="Aff102"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
One Baylor Plaza, Houston, Texas USA</nlm:aff>
<wicri:noCountry code="subfield">Texas USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Herberg, Friedrich W" sort="Herberg, Friedrich W" uniqKey="Herberg F" first="Friedrich W." last="Herberg">Friedrich W. Herberg</name>
<affiliation wicri:level="1"><nlm:aff id="Aff101"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1089 1036</institution-id>
<institution-id institution-id-type="GRID">grid.5155.4</institution-id>
<institution>Department of Biochemistry,</institution>
<institution>University of Kassel,</institution>
</institution-wrap>
34132 Kassel, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>34132 Kassel</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ghofrani, Hossein Ardeschir" sort="Ghofrani, Hossein Ardeschir" uniqKey="Ghofrani H" first="Hossein-Ardeschir" last="Ghofrani">Hossein-Ardeschir Ghofrani</name>
<affiliation wicri:level="1"><nlm:aff id="Aff103"><institution-wrap><institution-id institution-id-type="GRID">grid.440517.3</institution-id>
<institution>Department of Internal Medicine,</institution>
<institution>University of Giessen and Marburg Lung Center (UGMLC),</institution>
</institution-wrap>
Giessen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Giessen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Grimminger, Friedrich" sort="Grimminger, Friedrich" uniqKey="Grimminger F" first="Friedrich" last="Grimminger">Friedrich Grimminger</name>
<affiliation wicri:level="1"><nlm:aff id="Aff103"><institution-wrap><institution-id institution-id-type="GRID">grid.440517.3</institution-id>
<institution>Department of Internal Medicine,</institution>
<institution>University of Giessen and Marburg Lung Center (UGMLC),</institution>
</institution-wrap>
Giessen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Giessen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Grunig, Ekkehard" sort="Grunig, Ekkehard" uniqKey="Grunig E" first="Ekkehard" last="Grünig">Ekkehard Grünig</name>
<affiliation wicri:level="1"><nlm:aff id="Aff104"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0328 4908</institution-id>
<institution-id institution-id-type="GRID">grid.5253.1</institution-id>
<institution>Centre for Pulmonary Hypertension at the Thoraxclinic of University Hospital Heidelberg,</institution>
</institution-wrap>
Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huang, Yigao" sort="Huang, Yigao" uniqKey="Huang Y" first="Yigao" last="Huang">Yigao Huang</name>
<affiliation><nlm:aff id="Aff105"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1760 3705</institution-id>
<institution-id institution-id-type="GRID">grid.413352.2</institution-id>
<institution>Department of Cardiology, Guangdong General Hospital and Guangdong Cardiovascular Institute,</institution>
</institution-wrap>
Guangzhou, Guangdong China</nlm:aff>
<wicri:noCountry code="subfield">Guangdong China</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Jansa, Pavel" sort="Jansa, Pavel" uniqKey="Jansa P" first="Pavel" last="Jansa">Pavel Jansa</name>
<affiliation wicri:level="1"><nlm:aff id="Aff106"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9100 9940</institution-id>
<institution-id institution-id-type="GRID">grid.411798.2</institution-id>
<institution>Department of Cardiology and Angiology of the First Faculty of Medicine and General Teaching Hospital,</institution>
</institution-wrap>
Prague, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Prague</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jing, Zhi Cheng" sort="Jing, Zhi Cheng" uniqKey="Jing Z" first="Zhi Cheng" last="Jing">Zhi Cheng Jing</name>
<affiliation wicri:level="1"><nlm:aff id="Aff107"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0662 3178</institution-id>
<institution-id institution-id-type="GRID">grid.12527.33</institution-id>
<institution>State Key Laboratory of Cardiovascular Disease FuWai Hospital, National Center for Cardiovascular DiseasePeking Union Medical College and Chinese Academy of Medical Sciences,</institution>
</institution-wrap>
Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kilpatrick, David" sort="Kilpatrick, David" uniqKey="Kilpatrick D" first="David" last="Kilpatrick">David Kilpatrick</name>
<affiliation wicri:level="1"><nlm:aff id="Aff108"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 826X</institution-id>
<institution-id institution-id-type="GRID">grid.1009.8</institution-id>
<institution>Discipline of Medicine,</institution>
<institution>University of Tasmania,</institution>
</institution-wrap>
Hobart, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Hobart</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Langleben, David" sort="Langleben, David" uniqKey="Langleben D" first="David" last="Langleben">David Langleben</name>
<affiliation><nlm:aff id="Aff109"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8649</institution-id>
<institution-id institution-id-type="GRID">grid.14709.3b</institution-id>
<institution>Center for Pulmonary Vascular Disease,</institution>
<institution>McGill University,</institution>
</institution-wrap>
Montreal, QC Canada</nlm:aff>
<wicri:noCountry code="subfield">QC Canada</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Rosenkranz, Stephan" sort="Rosenkranz, Stephan" uniqKey="Rosenkranz S" first="Stephan" last="Rosenkranz">Stephan Rosenkranz</name>
<affiliation wicri:level="1"><nlm:aff id="Aff110"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8580 3777</institution-id>
<institution-id institution-id-type="GRID">grid.6190.e</institution-id>
<institution>Department III of Internal Medicine and Cologne Cardiovascular Research Centre,</institution>
<institution>Cologne University Heart Centre,</institution>
</institution-wrap>
Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Menezes, Flavia" sort="Menezes, Flavia" uniqKey="Menezes F" first="Flavia" last="Menezes">Flavia Menezes</name>
<affiliation wicri:level="1"><nlm:aff id="Aff111">Bayer HealthCare Pharmaceuticals, São Paulo, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Bayer HealthCare Pharmaceuticals, São Paulo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fritsch, Arno" sort="Fritsch, Arno" uniqKey="Fritsch A" first="Arno" last="Fritsch">Arno Fritsch</name>
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<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Global Clinical Development, Bayer AG,</institution>
</institution-wrap>
Wuppertal, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Wuppertal</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nikkho, Sylvia" sort="Nikkho, Sylvia" uniqKey="Nikkho S" first="Sylvia" last="Nikkho">Sylvia Nikkho</name>
<affiliation wicri:level="1"><nlm:aff id="Aff113"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Global Clinical Development, Bayer AG,</institution>
</institution-wrap>
Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Frey, Reiner" sort="Frey, Reiner" uniqKey="Frey R" first="Reiner" last="Frey">Reiner Frey</name>
<affiliation wicri:level="1"><nlm:aff id="Aff113"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Global Clinical Development, Bayer AG,</institution>
</institution-wrap>
Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Humbert, Marc" sort="Humbert, Marc" uniqKey="Humbert M" first="Marc" last="Humbert">Marc Humbert</name>
<affiliation wicri:level="1"><nlm:aff id="Aff114"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 4910 6535</institution-id>
<institution-id institution-id-type="GRID">grid.460789.4</institution-id>
<institution>Université Paris-Sud,</institution>
<institution>Université Paris-Saclay,</institution>
</institution-wrap>
Le Kremlin Bicêtre, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Le Kremlin Bicêtre</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Groneberg, Dieter" sort="Groneberg, Dieter" uniqKey="Groneberg D" first="Dieter" last="Groneberg">Dieter Groneberg</name>
<affiliation wicri:level="1"><nlm:aff id="Aff115"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aue, Annemarie" sort="Aue, Annemarie" uniqKey="Aue A" first="Annemarie" last="Aue">Annemarie Aue</name>
<affiliation wicri:level="1"><nlm:aff id="Aff115"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schwiering, Fabian" sort="Schwiering, Fabian" uniqKey="Schwiering F" first="Fabian" last="Schwiering">Fabian Schwiering</name>
<affiliation wicri:level="1"><nlm:aff id="Aff115"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Friebe, Andreas" sort="Friebe, Andreas" uniqKey="Friebe A" first="Andreas" last="Friebe">Andreas Friebe</name>
<affiliation wicri:level="1"><nlm:aff id="Aff115"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Harloff, Manuela" sort="Harloff, Manuela" uniqKey="Harloff M" first="Manuela" last="Harloff">Manuela Harloff</name>
<affiliation wicri:level="1"><nlm:aff id="Aff116"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 5763</institution-id>
<institution-id institution-id-type="GRID">grid.7727.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Regensburg,</institution>
</institution-wrap>
93053 Regensburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>93053 Regensburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Reinders, Joerg" sort="Reinders, Joerg" uniqKey="Reinders J" first="Joerg" last="Reinders">Joerg Reinders</name>
<affiliation wicri:level="1"><nlm:aff id="Aff117"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 5763</institution-id>
<institution-id institution-id-type="GRID">grid.7727.5</institution-id>
<institution>Department Functional Genomics,</institution>
<institution>University of Regensburg,</institution>
</institution-wrap>
93053 Regensburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>93053 Regensburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schlossmann, Jens" sort="Schlossmann, Jens" uniqKey="Schlossmann J" first="Jens" last="Schlossmann">Jens Schlossmann</name>
<affiliation wicri:level="1"><nlm:aff id="Aff116"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 5763</institution-id>
<institution-id institution-id-type="GRID">grid.7727.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Regensburg,</institution>
</institution-wrap>
93053 Regensburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>93053 Regensburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jung, Joon" sort="Jung, Joon" uniqKey="Jung J" first="Joon" last="Jung">Joon Jung</name>
<affiliation wicri:level="2"><nlm:aff id="Aff118"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wales, Jessica A" sort="Wales, Jessica A" uniqKey="Wales J" first="Jessica A." last="Wales">Jessica A. Wales</name>
<affiliation><nlm:aff id="Aff119"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2168 186X</institution-id>
<institution-id institution-id-type="GRID">grid.134563.6</institution-id>
<institution>Department of Chemistry and Biochemistry,</institution>
<institution>University of Arizona,</institution>
</institution-wrap>
Tucson, AZ 8572 USA</nlm:aff>
<wicri:noCountry code="subfield">AZ 8572 USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Chen, Cheng Yu" sort="Chen, Cheng Yu" uniqKey="Chen C" first="Cheng-Yu" last="Chen">Cheng-Yu Chen</name>
<affiliation><nlm:aff id="Aff119"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2168 186X</institution-id>
<institution-id institution-id-type="GRID">grid.134563.6</institution-id>
<institution>Department of Chemistry and Biochemistry,</institution>
<institution>University of Arizona,</institution>
</institution-wrap>
Tucson, AZ 8572 USA</nlm:aff>
<wicri:noCountry code="subfield">AZ 8572 USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Breci, Linda" sort="Breci, Linda" uniqKey="Breci L" first="Linda" last="Breci">Linda Breci</name>
<affiliation><nlm:aff id="Aff119"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2168 186X</institution-id>
<institution-id institution-id-type="GRID">grid.134563.6</institution-id>
<institution>Department of Chemistry and Biochemistry,</institution>
<institution>University of Arizona,</institution>
</institution-wrap>
Tucson, AZ 8572 USA</nlm:aff>
<wicri:noCountry code="subfield">AZ 8572 USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Weichsel, Andrzej" sort="Weichsel, Andrzej" uniqKey="Weichsel A" first="Andrzej" last="Weichsel">Andrzej Weichsel</name>
<affiliation><nlm:aff id="Aff119"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2168 186X</institution-id>
<institution-id institution-id-type="GRID">grid.134563.6</institution-id>
<institution>Department of Chemistry and Biochemistry,</institution>
<institution>University of Arizona,</institution>
</institution-wrap>
Tucson, AZ 8572 USA</nlm:aff>
<wicri:noCountry code="subfield">AZ 8572 USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bernier, Sylvie G" sort="Bernier, Sylvie G" uniqKey="Bernier S" first="Sylvie G." last="Bernier">Sylvie G. Bernier</name>
<affiliation wicri:level="2"><nlm:aff id="Aff118"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Solinga, Robert" sort="Solinga, Robert" uniqKey="Solinga R" first="Robert" last="Solinga">Robert Solinga</name>
<affiliation wicri:level="2"><nlm:aff id="Aff118"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sheppeck, James E" sort="Sheppeck, James E" uniqKey="Sheppeck J" first="James E." last="Sheppeck">James E. Sheppeck</name>
<affiliation wicri:level="2"><nlm:aff id="Aff118"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Renhowe, Paul A" sort="Renhowe, Paul A" uniqKey="Renhowe P" first="Paul A." last="Renhowe">Paul A. Renhowe</name>
<affiliation wicri:level="2"><nlm:aff id="Aff118"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Montfort, William R" sort="Montfort, William R" uniqKey="Montfort W" first="William R." last="Montfort">William R. Montfort</name>
<affiliation><nlm:aff id="Aff119"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2168 186X</institution-id>
<institution-id institution-id-type="GRID">grid.134563.6</institution-id>
<institution>Department of Chemistry and Biochemistry,</institution>
<institution>University of Arizona,</institution>
</institution-wrap>
Tucson, AZ 8572 USA</nlm:aff>
<wicri:noCountry code="subfield">AZ 8572 USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Qin, Liying" sort="Qin, Liying" uniqKey="Qin L" first="Liying" last="Qin">Liying Qin</name>
<affiliation><nlm:aff id="Aff120"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Verna and Marrs McLean Department of Biochemistry and Molecular Biology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, Texas USA</nlm:aff>
<wicri:noCountry code="subfield">Texas USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sung, Ying Ju" sort="Sung, Ying Ju" uniqKey="Sung Y" first="Ying-Ju" last="Sung">Ying-Ju Sung</name>
<affiliation wicri:level="2"><nlm:aff id="Aff121"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0448 6255</institution-id>
<institution-id institution-id-type="GRID">grid.414627.2</institution-id>
<institution>Geisinger Commonwealth School of Medicine, Commonwealth Medical College,</institution>
</institution-wrap>
Scranton, PA 18509 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Scranton</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Casteel, Darren" sort="Casteel, Darren" uniqKey="Casteel D" first="Darren" last="Casteel">Darren Casteel</name>
<affiliation wicri:level="1"><nlm:aff id="Aff122"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2181 7878</institution-id>
<institution-id institution-id-type="GRID">grid.47840.3f</institution-id>
<institution>Department of Medicine,</institution>
<institution>University of California,</institution>
</institution-wrap>
San Diego, La Jolla, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>San Diego, La Jolla, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kim, Choel" sort="Kim, Choel" uniqKey="Kim C" first="Choel" last="Kim">Choel Kim</name>
<affiliation><nlm:aff id="Aff120"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Verna and Marrs McLean Department of Biochemistry and Molecular Biology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, Texas USA</nlm:aff>
<wicri:noCountry code="subfield">Texas USA</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff123"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, Texas USA</nlm:aff>
<wicri:noCountry code="subfield">Texas USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kollau, Alexander" sort="Kollau, Alexander" uniqKey="Kollau A" first="Alexander" last="Kollau">Alexander Kollau</name>
<affiliation wicri:level="1"><nlm:aff id="Aff124"><institution-wrap><institution-id institution-id-type="ISNI">0000000121539003</institution-id>
<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
A 8010, Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A 8010, Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Neubauer, Andrea" sort="Neubauer, Andrea" uniqKey="Neubauer A" first="Andrea" last="Neubauer">Andrea Neubauer</name>
<affiliation wicri:level="1"><nlm:aff id="Aff124"><institution-wrap><institution-id institution-id-type="ISNI">0000000121539003</institution-id>
<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
A 8010, Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A 8010, Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schrammel, Astrid" sort="Schrammel, Astrid" uniqKey="Schrammel A" first="Astrid" last="Schrammel">Astrid Schrammel</name>
<affiliation wicri:level="1"><nlm:aff id="Aff124"><institution-wrap><institution-id institution-id-type="ISNI">0000000121539003</institution-id>
<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
A 8010, Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A 8010, Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Russwurm, Michael" sort="Russwurm, Michael" uniqKey="Russwurm M" first="Michael" last="Russwurm">Michael Russwurm</name>
<affiliation wicri:level="1"><nlm:aff id="Aff125"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>Ruhr University Bochum,</institution>
</institution-wrap>
D 44780 Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>D 44780 Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koesling, Doris" sort="Koesling, Doris" uniqKey="Koesling D" first="Doris" last="Koesling">Doris Koesling</name>
<affiliation wicri:level="1"><nlm:aff id="Aff125"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>Ruhr University Bochum,</institution>
</institution-wrap>
D 44780 Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>D 44780 Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mayer, Bernd" sort="Mayer, Bernd" uniqKey="Mayer B" first="Bernd" last="Mayer">Bernd Mayer</name>
<affiliation wicri:level="1"><nlm:aff id="Aff124"><institution-wrap><institution-id institution-id-type="ISNI">0000000121539003</institution-id>
<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
A 8010, Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A 8010, Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kumazoe, Motofumi" sort="Kumazoe, Motofumi" uniqKey="Kumazoe M" first="Motofumi" last="Kumazoe">Motofumi Kumazoe</name>
<affiliation wicri:level="1"><nlm:aff id="Aff126"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2242 4849</institution-id>
<institution-id institution-id-type="GRID">grid.177174.3</institution-id>
<institution>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture,</institution>
<institution>Kyushu University,</institution>
</institution-wrap>
6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581 Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>6-10-1 Hakozaki, Higashi-ku, Fukuoka</wicri:regionArea>
</affiliation>
<affiliation><nlm:aff id="Aff127"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
5-7-1 Fujishiro-dai, Suita-City, Osaka 565-8565 Japan</nlm:aff>
<wicri:noCountry code="subfield">Osaka 565-8565 Japan</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Takai, Mika" sort="Takai, Mika" uniqKey="Takai M" first="Mika" last="Takai">Mika Takai</name>
<affiliation wicri:level="1"><nlm:aff id="Aff126"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2242 4849</institution-id>
<institution-id institution-id-type="GRID">grid.177174.3</institution-id>
<institution>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture,</institution>
<institution>Kyushu University,</institution>
</institution-wrap>
6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581 Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>6-10-1 Hakozaki, Higashi-ku, Fukuoka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Takeuchi, Chieri" sort="Takeuchi, Chieri" uniqKey="Takeuchi C" first="Chieri" last="Takeuchi">Chieri Takeuchi</name>
<affiliation wicri:level="1"><nlm:aff id="Aff126"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2242 4849</institution-id>
<institution-id institution-id-type="GRID">grid.177174.3</institution-id>
<institution>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture,</institution>
<institution>Kyushu University,</institution>
</institution-wrap>
6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581 Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>6-10-1 Hakozaki, Higashi-ku, Fukuoka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kadomatsu, Mai" sort="Kadomatsu, Mai" uniqKey="Kadomatsu M" first="Mai" last="Kadomatsu">Mai Kadomatsu</name>
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<institution-id institution-id-type="GRID">grid.177174.3</institution-id>
<institution>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture,</institution>
<institution>Kyushu University,</institution>
</institution-wrap>
6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581 Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>6-10-1 Hakozaki, Higashi-ku, Fukuoka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hiroi, Shun" sort="Hiroi, Shun" uniqKey="Hiroi S" first="Shun" last="Hiroi">Shun Hiroi</name>
<affiliation wicri:level="1"><nlm:aff id="Aff126"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2242 4849</institution-id>
<institution-id institution-id-type="GRID">grid.177174.3</institution-id>
<institution>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture,</institution>
<institution>Kyushu University,</institution>
</institution-wrap>
6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581 Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>6-10-1 Hakozaki, Higashi-ku, Fukuoka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Takamatsu, Kanako" sort="Takamatsu, Kanako" uniqKey="Takamatsu K" first="Kanako" last="Takamatsu">Kanako Takamatsu</name>
<affiliation wicri:level="1"><nlm:aff id="Aff126"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2242 4849</institution-id>
<institution-id institution-id-type="GRID">grid.177174.3</institution-id>
<institution>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture,</institution>
<institution>Kyushu University,</institution>
</institution-wrap>
6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581 Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>6-10-1 Hakozaki, Higashi-ku, Fukuoka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nojiri, Takashi" sort="Nojiri, Takashi" uniqKey="Nojiri T" first="Takashi" last="Nojiri">Takashi Nojiri</name>
<affiliation><nlm:aff id="Aff127"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
5-7-1 Fujishiro-dai, Suita-City, Osaka 565-8565 Japan</nlm:aff>
<wicri:noCountry code="subfield">Osaka 565-8565 Japan</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kangawa, Kenji" sort="Kangawa, Kenji" uniqKey="Kangawa K" first="Kenji" last="Kangawa">Kenji Kangawa</name>
<affiliation><nlm:aff id="Aff127"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
5-7-1 Fujishiro-dai, Suita-City, Osaka 565-8565 Japan</nlm:aff>
<wicri:noCountry code="subfield">Osaka 565-8565 Japan</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Tachibana, Hirofumi" sort="Tachibana, Hirofumi" uniqKey="Tachibana H" first="Hirofumi" last="Tachibana">Hirofumi Tachibana</name>
<affiliation wicri:level="1"><nlm:aff id="Aff126"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2242 4849</institution-id>
<institution-id institution-id-type="GRID">grid.177174.3</institution-id>
<institution>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture,</institution>
<institution>Kyushu University,</institution>
</institution-wrap>
6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581 Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>6-10-1 Hakozaki, Higashi-ku, Fukuoka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Opelt, Marissa" sort="Opelt, Marissa" uniqKey="Opelt M" first="Marissa" last="Opelt">Marissa Opelt</name>
<affiliation wicri:level="1"><nlm:aff id="Aff128"><institution-wrap><institution-id institution-id-type="ISNI">0000000121539003</institution-id>
<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Institute of Pharmaceutical Sciences, Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eroglu, Emrah" sort="Eroglu, Emrah" uniqKey="Eroglu E" first="Emrah" last="Eroglu">Emrah Eroglu</name>
<affiliation wicri:level="1"><nlm:aff id="Aff129"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8988 2476</institution-id>
<institution-id institution-id-type="GRID">grid.11598.34</institution-id>
<institution>Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine,</institution>
<institution>Medical University of Graz,</institution>
</institution-wrap>
Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Waldeck Weiermair, Markus" sort="Waldeck Weiermair, Markus" uniqKey="Waldeck Weiermair M" first="Markus" last="Waldeck-Weiermair">Markus Waldeck-Weiermair</name>
<affiliation wicri:level="1"><nlm:aff id="Aff129"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8988 2476</institution-id>
<institution-id institution-id-type="GRID">grid.11598.34</institution-id>
<institution>Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine,</institution>
<institution>Medical University of Graz,</institution>
</institution-wrap>
Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Russwurm, Michael" sort="Russwurm, Michael" uniqKey="Russwurm M" first="Michael" last="Russwurm">Michael Russwurm</name>
<affiliation wicri:level="1"><nlm:aff id="Aff130"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>Ruhr University Bochum,</institution>
</institution-wrap>
Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koesling, Doris" sort="Koesling, Doris" uniqKey="Koesling D" first="Doris" last="Koesling">Doris Koesling</name>
<affiliation wicri:level="1"><nlm:aff id="Aff130"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>Ruhr University Bochum,</institution>
</institution-wrap>
Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Malli, Roland" sort="Malli, Roland" uniqKey="Malli R" first="Roland" last="Malli">Roland Malli</name>
<affiliation wicri:level="1"><nlm:aff id="Aff129"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8988 2476</institution-id>
<institution-id institution-id-type="GRID">grid.11598.34</institution-id>
<institution>Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine,</institution>
<institution>Medical University of Graz,</institution>
</institution-wrap>
Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Graier, Wolfgang F" sort="Graier, Wolfgang F" uniqKey="Graier W" first="Wolfgang F." last="Graier">Wolfgang F. Graier</name>
<affiliation wicri:level="1"><nlm:aff id="Aff129"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8988 2476</institution-id>
<institution-id institution-id-type="GRID">grid.11598.34</institution-id>
<institution>Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine,</institution>
<institution>Medical University of Graz,</institution>
</institution-wrap>
Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fassett, John T" sort="Fassett, John T" uniqKey="Fassett J" first="John T." last="Fassett">John T. Fassett</name>
<affiliation wicri:level="1"><nlm:aff id="Aff128"><institution-wrap><institution-id institution-id-type="ISNI">0000000121539003</institution-id>
<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Institute of Pharmaceutical Sciences, Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schrammel, Astrid" sort="Schrammel, Astrid" uniqKey="Schrammel A" first="Astrid" last="Schrammel">Astrid Schrammel</name>
<affiliation wicri:level="1"><nlm:aff id="Aff128"><institution-wrap><institution-id institution-id-type="ISNI">0000000121539003</institution-id>
<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Institute of Pharmaceutical Sciences, Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mayer, Bernd" sort="Mayer, Bernd" uniqKey="Mayer B" first="Bernd" last="Mayer">Bernd Mayer</name>
<affiliation wicri:level="1"><nlm:aff id="Aff128"><institution-wrap><institution-id institution-id-type="ISNI">0000000121539003</institution-id>
<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Institute of Pharmaceutical Sciences, Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sollie, Selene J" sort="Sollie, Selene J" uniqKey="Sollie S" first="Selene J." last="Sollie">Selene J. Sollie</name>
<affiliation wicri:level="1"><nlm:aff id="Aff131"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology, Faculty of Medicine,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff132"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research, Faculty of Medicine,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Moltzau, Lise Roman" sort="Moltzau, Lise Roman" uniqKey="Moltzau L" first="Lise Román" last="Moltzau">Lise Román Moltzau</name>
<affiliation wicri:level="1"><nlm:aff id="Aff131"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology, Faculty of Medicine,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff132"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research, Faculty of Medicine,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hernandez Valladares, Maria" sort="Hernandez Valladares, Maria" uniqKey="Hernandez Valladares M" first="Maria" last="Hernandez-Valladares">Maria Hernandez-Valladares</name>
<affiliation wicri:level="1"><nlm:aff id="Aff133"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7443</institution-id>
<institution-id institution-id-type="GRID">grid.7914.b</institution-id>
<institution>Department of Biomedicine, Faculty of Medicine and Dentistry,</institution>
<institution>University of Bergen,</institution>
</institution-wrap>
Bergen, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Bergen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Berven, Frode" sort="Berven, Frode" uniqKey="Berven F" first="Frode" last="Berven">Frode Berven</name>
<affiliation wicri:level="1"><nlm:aff id="Aff133"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7443</institution-id>
<institution-id institution-id-type="GRID">grid.7914.b</institution-id>
<institution>Department of Biomedicine, Faculty of Medicine and Dentistry,</institution>
<institution>University of Bergen,</institution>
</institution-wrap>
Bergen, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Bergen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Levy, Finn Olav" sort="Levy, Finn Olav" uniqKey="Levy F" first="Finn Olav" last="Levy">Finn Olav Levy</name>
<affiliation wicri:level="1"><nlm:aff id="Aff131"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology, Faculty of Medicine,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff132"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research, Faculty of Medicine,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Andressen, Kjetil W" sort="Andressen, Kjetil W" uniqKey="Andressen K" first="Kjetil W." last="Andressen">Kjetil W. Andressen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff131"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology, Faculty of Medicine,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff132"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research, Faculty of Medicine,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nojiri, Takashi" sort="Nojiri, Takashi" uniqKey="Nojiri T" first="Takashi" last="Nojiri">Takashi Nojiri</name>
<affiliation wicri:level="1"><nlm:aff id="Aff134"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff135"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0373 3971</institution-id>
<institution-id institution-id-type="GRID">grid.136593.b</institution-id>
<institution>Department of General Thoracic Surgery,</institution>
<institution>Osaka University Graduate School of Medicine,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tokudome, Takeshi" sort="Tokudome, Takeshi" uniqKey="Tokudome T" first="Takeshi" last="Tokudome">Takeshi Tokudome</name>
<affiliation wicri:level="1"><nlm:aff id="Aff134"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kumazoe, Motofumi" sort="Kumazoe, Motofumi" uniqKey="Kumazoe M" first="Motofumi" last="Kumazoe">Motofumi Kumazoe</name>
<affiliation wicri:level="1"><nlm:aff id="Aff134"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arai, Miki" sort="Arai, Miki" uniqKey="Arai M" first="Miki" last="Arai">Miki Arai</name>
<affiliation wicri:level="1"><nlm:aff id="Aff136"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 1583</institution-id>
<institution-id institution-id-type="GRID">grid.418163.9</institution-id>
<institution>Advanced Telecommunications Research Institute International (ATR), The Thomas N. Sato BioMEC-X Laboratories,</institution>
</institution-wrap>
Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Kyoto</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff137"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2151 536X</institution-id>
<institution-id institution-id-type="GRID">grid.26999.3d</institution-id>
<institution>The University of Tokyo, graduate school of frontier science,</institution>
</institution-wrap>
Kashiwa, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Kashiwa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Suzuki, Yutaka" sort="Suzuki, Yutaka" uniqKey="Suzuki Y" first="Yutaka" last="Suzuki">Yutaka Suzuki</name>
<affiliation wicri:level="1"><nlm:aff id="Aff137"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2151 536X</institution-id>
<institution-id institution-id-type="GRID">grid.26999.3d</institution-id>
<institution>The University of Tokyo, graduate school of frontier science,</institution>
</institution-wrap>
Kashiwa, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Kashiwa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Miura, Koichi" sort="Miura, Koichi" uniqKey="Miura K" first="Koichi" last="Miura">Koichi Miura</name>
<affiliation wicri:level="1"><nlm:aff id="Aff134"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hino, Jun" sort="Hino, Jun" uniqKey="Hino J" first="Jun" last="Hino">Jun Hino</name>
<affiliation wicri:level="1"><nlm:aff id="Aff134"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hosoda, Hiroshi" sort="Hosoda, Hiroshi" uniqKey="Hosoda H" first="Hiroshi" last="Hosoda">Hiroshi Hosoda</name>
<affiliation wicri:level="1"><nlm:aff id="Aff138"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Miyazato, Mikiya" sort="Miyazato, Mikiya" uniqKey="Miyazato M" first="Mikiya" last="Miyazato">Mikiya Miyazato</name>
<affiliation wicri:level="1"><nlm:aff id="Aff134"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Okumura, Meinoshin" sort="Okumura, Meinoshin" uniqKey="Okumura M" first="Meinoshin" last="Okumura">Meinoshin Okumura</name>
<affiliation wicri:level="1"><nlm:aff id="Aff135"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0373 3971</institution-id>
<institution-id institution-id-type="GRID">grid.136593.b</institution-id>
<institution>Department of General Thoracic Surgery,</institution>
<institution>Osaka University Graduate School of Medicine,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kawaoka, Shinpei" sort="Kawaoka, Shinpei" uniqKey="Kawaoka S" first="Shinpei" last="Kawaoka">Shinpei Kawaoka</name>
<affiliation wicri:level="1"><nlm:aff id="Aff136"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 1583</institution-id>
<institution-id institution-id-type="GRID">grid.418163.9</institution-id>
<institution>Advanced Telecommunications Research Institute International (ATR), The Thomas N. Sato BioMEC-X Laboratories,</institution>
</institution-wrap>
Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Kyoto</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kangawa, Kenji" sort="Kangawa, Kenji" uniqKey="Kangawa K" first="Kenji" last="Kangawa">Kenji Kangawa</name>
<affiliation wicri:level="1"><nlm:aff id="Aff134"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peters, Stefanie" sort="Peters, Stefanie" uniqKey="Peters S" first="Stefanie" last="Peters">Stefanie Peters</name>
<affiliation wicri:level="1"><nlm:aff id="Aff139"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmidt, Hannes" sort="Schmidt, Hannes" uniqKey="Schmidt H" first="Hannes" last="Schmidt">Hannes Schmidt</name>
<affiliation wicri:level="1"><nlm:aff id="Aff140"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1014 0849</institution-id>
<institution-id institution-id-type="GRID">grid.419491.0</institution-id>
<institution>Max-Delbrück-Centrum für Molekulare Medizin,</institution>
</institution-wrap>
Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Berlin</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff143"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Present address: Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Selin Kenet, B" sort="Selin Kenet, B" uniqKey="Selin Kenet B" first="B." last="Selin Kenet">B. Selin Kenet</name>
<affiliation wicri:level="1"><nlm:aff id="Aff139"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
<affiliation><nlm:aff id="Aff141">Present address: Institut für Zellbiologie des Nervensystems, München, TU Germany</nlm:aff>
<wicri:noCountry code="subfield">TU Germany</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Nies, Sarah Helena" sort="Nies, Sarah Helena" uniqKey="Nies S" first="Sarah Helena" last="Nies">Sarah Helena Nies</name>
<affiliation wicri:level="1"><nlm:aff id="Aff139"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Frank, Katharina" sort="Frank, Katharina" uniqKey="Frank K" first="Katharina" last="Frank">Katharina Frank</name>
<affiliation wicri:level="1"><nlm:aff id="Aff140"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1014 0849</institution-id>
<institution-id institution-id-type="GRID">grid.419491.0</institution-id>
<institution>Max-Delbrück-Centrum für Molekulare Medizin,</institution>
</institution-wrap>
Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Berlin</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff142"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 973X</institution-id>
<institution-id institution-id-type="GRID">grid.5252.0</institution-id>
<institution>Present address: Institut für Immunologie, BioMedical Center, LMU,</institution>
</institution-wrap>
Planegg-Martinsried, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Planegg-Martinsried</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wen, Lai" sort="Wen, Lai" uniqKey="Wen L" first="Lai" last="Wen">Lai Wen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff139"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rathjen, Fritz G" sort="Rathjen, Fritz G" uniqKey="Rathjen F" first="Fritz G." last="Rathjen">Fritz G. Rathjen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff140"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1014 0849</institution-id>
<institution-id institution-id-type="GRID">grid.419491.0</institution-id>
<institution>Max-Delbrück-Centrum für Molekulare Medizin,</institution>
</institution-wrap>
Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Feil, Robert" sort="Feil, Robert" uniqKey="Feil R" first="Robert" last="Feil">Robert Feil</name>
<affiliation wicri:level="1"><nlm:aff id="Aff139"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Petrova, Olga N" sort="Petrova, Olga N" uniqKey="Petrova O" first="Olga N." last="Petrova">Olga N. Petrova</name>
<affiliation wicri:level="1"><nlm:aff id="Aff144"><institution-wrap><institution-id institution-id-type="ISNI">0000000121581279</institution-id>
<institution-id institution-id-type="GRID">grid.10877.39</institution-id>
<institution>Laboratory for Optics and Biosciences,</institution>
<institution>Ecole Polytechnique,</institution>
</institution-wrap>
Palaiseau, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Palaiseau</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lamarre, Isabelle" sort="Lamarre, Isabelle" uniqKey="Lamarre I" first="Isabelle" last="Lamarre">Isabelle Lamarre</name>
<affiliation wicri:level="1"><nlm:aff id="Aff144"><institution-wrap><institution-id institution-id-type="ISNI">0000000121581279</institution-id>
<institution-id institution-id-type="GRID">grid.10877.39</institution-id>
<institution>Laboratory for Optics and Biosciences,</institution>
<institution>Ecole Polytechnique,</institution>
</institution-wrap>
Palaiseau, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Palaiseau</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Negrerie, Michel" sort="Negrerie, Michel" uniqKey="Negrerie M" first="Michel" last="Négrerie">Michel Négrerie</name>
<affiliation wicri:level="1"><nlm:aff id="Aff144"><institution-wrap><institution-id institution-id-type="ISNI">0000000121581279</institution-id>
<institution-id institution-id-type="GRID">grid.10877.39</institution-id>
<institution>Laboratory for Optics and Biosciences,</institution>
<institution>Ecole Polytechnique,</institution>
</institution-wrap>
Palaiseau, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Palaiseau</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Robinson, Jerid W" sort="Robinson, Jerid W" uniqKey="Robinson J" first="Jerid W." last="Robinson">Jerid W. Robinson</name>
<affiliation wicri:level="2"><nlm:aff id="Aff145"><institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Biochemistry, Molecular Biology, and Biophysics,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, MN USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Egbert, Jeremy R" sort="Egbert, Jeremy R" uniqKey="Egbert J" first="Jeremy R." last="Egbert">Jeremy R. Egbert</name>
<affiliation wicri:level="2"><nlm:aff id="Aff146"><institution-wrap><institution-id institution-id-type="ISNI">0000000419370394</institution-id>
<institution-id institution-id-type="GRID">grid.208078.5</institution-id>
<institution>Department of Cell Biology,</institution>
<institution>University of Connecticut Health Center,</institution>
</institution-wrap>
Farmington, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Farmington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Davydova, Julia" sort="Davydova, Julia" uniqKey="Davydova J" first="Julia" last="Davydova">Julia Davydova</name>
<affiliation wicri:level="2"><nlm:aff id="Aff147"><institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Surgery,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, MN USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jaffe, Laurinda A" sort="Jaffe, Laurinda A" uniqKey="Jaffe L" first="Laurinda A." last="Jaffe">Laurinda A. Jaffe</name>
<affiliation wicri:level="2"><nlm:aff id="Aff146"><institution-wrap><institution-id institution-id-type="ISNI">0000000419370394</institution-id>
<institution-id institution-id-type="GRID">grid.208078.5</institution-id>
<institution>Department of Cell Biology,</institution>
<institution>University of Connecticut Health Center,</institution>
</institution-wrap>
Farmington, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Farmington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Potter, Lincoln R" sort="Potter, Lincoln R" uniqKey="Potter L" first="Lincoln R." last="Potter">Lincoln R. Potter</name>
<affiliation wicri:level="2"><nlm:aff id="Aff145"><institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Biochemistry, Molecular Biology, and Biophysics,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, MN USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Minneapolis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff148"><institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, MN USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Robinson, Jerid W" sort="Robinson, Jerid W" uniqKey="Robinson J" first="Jerid W." last="Robinson">Jerid W. Robinson</name>
<affiliation wicri:level="2"><nlm:aff id="Aff149"><institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Biochemistry, Molecular Biology, and Biophysics,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, MN USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Blixt, Nicholas" sort="Blixt, Nicholas" uniqKey="Blixt N" first="Nicholas" last="Blixt">Nicholas Blixt</name>
<affiliation wicri:level="2"><nlm:aff id="Aff150"><institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Developmental and Surgical Sciences,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, MN USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Shuhaibar, Leia C" sort="Shuhaibar, Leia C" uniqKey="Shuhaibar L" first="Leia C." last="Shuhaibar">Leia C. Shuhaibar</name>
<affiliation wicri:level="2"><nlm:aff id="Aff151"><institution-wrap><institution-id institution-id-type="ISNI">0000000419370394</institution-id>
<institution-id institution-id-type="GRID">grid.208078.5</institution-id>
<institution>Department of Cell Biology,</institution>
<institution>University of Connecticut Health Center,</institution>
</institution-wrap>
Farmington, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Farmington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Warren, Gordon L" sort="Warren, Gordon L" uniqKey="Warren G" first="Gordon L." last="Warren">Gordon L. Warren</name>
<affiliation wicri:level="2"><nlm:aff id="Aff152"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7400</institution-id>
<institution-id institution-id-type="GRID">grid.256304.6</institution-id>
<institution>Department of Physical Therapy,</institution>
<institution>Georgia State University,</institution>
</institution-wrap>
Atlanta, GA USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
<wicri:cityArea>Atlanta</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mansky, Kim C" sort="Mansky, Kim C" uniqKey="Mansky K" first="Kim C." last="Mansky">Kim C. Mansky</name>
<affiliation wicri:level="2"><nlm:aff id="Aff150"><institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Developmental and Surgical Sciences,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, MN USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jaffe, Laurinda A" sort="Jaffe, Laurinda A" uniqKey="Jaffe L" first="Laurinda A." last="Jaffe">Laurinda A. Jaffe</name>
<affiliation wicri:level="2"><nlm:aff id="Aff151"><institution-wrap><institution-id institution-id-type="ISNI">0000000419370394</institution-id>
<institution-id institution-id-type="GRID">grid.208078.5</institution-id>
<institution>Department of Cell Biology,</institution>
<institution>University of Connecticut Health Center,</institution>
</institution-wrap>
Farmington, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Farmington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Potter, Lincoln R" sort="Potter, Lincoln R" uniqKey="Potter L" first="Lincoln R." last="Potter">Lincoln R. Potter</name>
<affiliation wicri:level="2"><nlm:aff id="Aff149"><institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Biochemistry, Molecular Biology, and Biophysics,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, MN USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Minneapolis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff153"><institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, MN USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Romoli, Simone" sort="Romoli, Simone" uniqKey="Romoli S" first="Simone" last="Romoli">Simone Romoli</name>
<affiliation wicri:level="1"><nlm:aff id="Aff154"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Cardiovascular Research II, Therapeutic Research Group, Drug Discovery, Bayer AG,</institution>
</institution-wrap>
Wuppertal, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Wuppertal</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bauch, Tobias" sort="Bauch, Tobias" uniqKey="Bauch T" first="Tobias" last="Bauch">Tobias Bauch</name>
<affiliation wicri:level="1"><nlm:aff id="Aff154"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Cardiovascular Research II, Therapeutic Research Group, Drug Discovery, Bayer AG,</institution>
</institution-wrap>
Wuppertal, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Wuppertal</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Drobner, Karoline" sort="Drobner, Karoline" uniqKey="Drobner K" first="Karoline" last="Dröbner">Karoline Dröbner</name>
<affiliation wicri:level="1"><nlm:aff id="Aff154"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Cardiovascular Research II, Therapeutic Research Group, Drug Discovery, Bayer AG,</institution>
</institution-wrap>
Wuppertal, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Wuppertal</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eitner, Frank" sort="Eitner, Frank" uniqKey="Eitner F" first="Frank" last="Eitner">Frank Eitner</name>
<affiliation wicri:level="1"><nlm:aff id="Aff154"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Cardiovascular Research II, Therapeutic Research Group, Drug Discovery, Bayer AG,</institution>
</institution-wrap>
Wuppertal, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Wuppertal</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ruppert, Mihaly" sort="Ruppert, Mihaly" uniqKey="Ruppert M" first="Mihály" last="Ruppert">Mihály Ruppert</name>
<affiliation wicri:level="1"><nlm:aff id="Aff155"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 4373</institution-id>
<institution-id institution-id-type="GRID">grid.7700.0</institution-id>
<institution>Department of Cardiac Surgery,</institution>
<institution>University of Heidelberg,</institution>
</institution-wrap>
Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Heidelberg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff156"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0942 9821</institution-id>
<institution-id institution-id-type="GRID">grid.11804.3c</institution-id>
<institution>Heart and Vascular Center,</institution>
<institution>Semmelweis University,</institution>
</institution-wrap>
Budapest, Hungary</nlm:aff>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea>Budapest</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Radovits, Tamas" sort="Radovits, Tamas" uniqKey="Radovits T" first="Tamás" last="Radovits">Tamás Radovits</name>
<affiliation wicri:level="1"><nlm:aff id="Aff156"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0942 9821</institution-id>
<institution-id institution-id-type="GRID">grid.11804.3c</institution-id>
<institution>Heart and Vascular Center,</institution>
<institution>Semmelweis University,</institution>
</institution-wrap>
Budapest, Hungary</nlm:aff>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea>Budapest</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Korkmaz Icoz, Sevil" sort="Korkmaz Icoz, Sevil" uniqKey="Korkmaz Icoz S" first="Sevil" last="Korkmaz-Icöz">Sevil Korkmaz-Icöz</name>
<affiliation wicri:level="1"><nlm:aff id="Aff155"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 4373</institution-id>
<institution-id institution-id-type="GRID">grid.7700.0</institution-id>
<institution>Department of Cardiac Surgery,</institution>
<institution>University of Heidelberg,</institution>
</institution-wrap>
Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Li, Shiliang" sort="Li, Shiliang" uniqKey="Li S" first="Shiliang" last="Li">Shiliang Li</name>
<affiliation wicri:level="1"><nlm:aff id="Aff155"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 4373</institution-id>
<institution-id institution-id-type="GRID">grid.7700.0</institution-id>
<institution>Department of Cardiac Surgery,</institution>
<institution>University of Heidelberg,</institution>
</institution-wrap>
Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heged S, Peter" sort="Heged S, Peter" uniqKey="Heged S P" first="Péter" last="Heged S">Péter Heged S</name>
<affiliation wicri:level="1"><nlm:aff id="Aff155"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 4373</institution-id>
<institution-id institution-id-type="GRID">grid.7700.0</institution-id>
<institution>Department of Cardiac Surgery,</institution>
<institution>University of Heidelberg,</institution>
</institution-wrap>
Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Loganathan, Sivakanan" sort="Loganathan, Sivakanan" uniqKey="Loganathan S" first="Sivakanan" last="Loganathan">Sivakanan Loganathan</name>
<affiliation wicri:level="1"><nlm:aff id="Aff155"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 4373</institution-id>
<institution-id institution-id-type="GRID">grid.7700.0</institution-id>
<institution>Department of Cardiac Surgery,</institution>
<institution>University of Heidelberg,</institution>
</institution-wrap>
Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nemeth, Balazs Tamas" sort="Nemeth, Balazs Tamas" uniqKey="Nemeth B" first="Balázs Tamás" last="Németh">Balázs Tamás Németh</name>
<affiliation wicri:level="1"><nlm:aff id="Aff156"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0942 9821</institution-id>
<institution-id institution-id-type="GRID">grid.11804.3c</institution-id>
<institution>Heart and Vascular Center,</institution>
<institution>Semmelweis University,</institution>
</institution-wrap>
Budapest, Hungary</nlm:aff>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea>Budapest</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Olah, Attila" sort="Olah, Attila" uniqKey="Olah A" first="Attila" last="Oláh">Attila Oláh</name>
<affiliation wicri:level="1"><nlm:aff id="Aff156"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0942 9821</institution-id>
<institution-id institution-id-type="GRID">grid.11804.3c</institution-id>
<institution>Heart and Vascular Center,</institution>
<institution>Semmelweis University,</institution>
</institution-wrap>
Budapest, Hungary</nlm:aff>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea>Budapest</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Matyas, Csaba" sort="Matyas, Csaba" uniqKey="Matyas C" first="Csaba" last="Mátyás">Csaba Mátyás</name>
<affiliation wicri:level="1"><nlm:aff id="Aff156"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0942 9821</institution-id>
<institution-id institution-id-type="GRID">grid.11804.3c</institution-id>
<institution>Heart and Vascular Center,</institution>
<institution>Semmelweis University,</institution>
</institution-wrap>
Budapest, Hungary</nlm:aff>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea>Budapest</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Benke, Kalman" sort="Benke, Kalman" uniqKey="Benke K" first="Kálmán" last="Benke">Kálmán Benke</name>
<affiliation wicri:level="1"><nlm:aff id="Aff156"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0942 9821</institution-id>
<institution-id institution-id-type="GRID">grid.11804.3c</institution-id>
<institution>Heart and Vascular Center,</institution>
<institution>Semmelweis University,</institution>
</institution-wrap>
Budapest, Hungary</nlm:aff>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea>Budapest</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Merkely, Bela" sort="Merkely, Bela" uniqKey="Merkely B" first="Béla" last="Merkely">Béla Merkely</name>
<affiliation wicri:level="1"><nlm:aff id="Aff156"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0942 9821</institution-id>
<institution-id institution-id-type="GRID">grid.11804.3c</institution-id>
<institution>Heart and Vascular Center,</institution>
<institution>Semmelweis University,</institution>
</institution-wrap>
Budapest, Hungary</nlm:aff>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea>Budapest</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Karck, Matthias" sort="Karck, Matthias" uniqKey="Karck M" first="Matthias" last="Karck">Matthias Karck</name>
<affiliation wicri:level="1"><nlm:aff id="Aff155"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 4373</institution-id>
<institution-id institution-id-type="GRID">grid.7700.0</institution-id>
<institution>Department of Cardiac Surgery,</institution>
<institution>University of Heidelberg,</institution>
</institution-wrap>
Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Szab, Gabor" sort="Szab, Gabor" uniqKey="Szab G" first="Gábor" last="Szab">Gábor Szab</name>
<affiliation wicri:level="1"><nlm:aff id="Aff155"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 4373</institution-id>
<institution-id institution-id-type="GRID">grid.7700.0</institution-id>
<institution>Department of Cardiac Surgery,</institution>
<institution>University of Heidelberg,</institution>
</institution-wrap>
Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Scheib, Ulrike" sort="Scheib, Ulrike" uniqKey="Scheib U" first="Ulrike" last="Scheib">Ulrike Scheib</name>
<affiliation wicri:level="1"><nlm:aff id="Aff157">Humboldt Universität zu Berlin, Institute for Biology, Experimental Biophysics, Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Humboldt Universität zu Berlin, Institute for Biology, Experimental Biophysics, Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Broser, Matthias" sort="Broser, Matthias" uniqKey="Broser M" first="Matthias" last="Broser">Matthias Broser</name>
<affiliation wicri:level="1"><nlm:aff id="Aff157">Humboldt Universität zu Berlin, Institute for Biology, Experimental Biophysics, Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Humboldt Universität zu Berlin, Institute for Biology, Experimental Biophysics, Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mukherjee, Shatanik" sort="Mukherjee, Shatanik" uniqKey="Mukherjee S" first="Shatanik" last="Mukherjee">Shatanik Mukherjee</name>
<affiliation wicri:level="1"><nlm:aff id="Aff157">Humboldt Universität zu Berlin, Institute for Biology, Experimental Biophysics, Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Humboldt Universität zu Berlin, Institute for Biology, Experimental Biophysics, Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stehfest, Katja" sort="Stehfest, Katja" uniqKey="Stehfest K" first="Katja" last="Stehfest">Katja Stehfest</name>
<affiliation wicri:level="1"><nlm:aff id="Aff157">Humboldt Universität zu Berlin, Institute for Biology, Experimental Biophysics, Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Humboldt Universität zu Berlin, Institute for Biology, Experimental Biophysics, Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gee, Christine E" sort="Gee, Christine E" uniqKey="Gee C" first="Christine E." last="Gee">Christine E. Gee</name>
<affiliation wicri:level="1"><nlm:aff id="Aff158">University Medical Center Hamburg-Eppendorf, Center for Molecular Neurobiology Hamburg, Institute for Synaptic Physiology, Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University Medical Center Hamburg-Eppendorf, Center for Molecular Neurobiology Hamburg, Institute for Synaptic Physiology, Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Korschen, Heinz G" sort="Korschen, Heinz G" uniqKey="Korschen H" first="Heinz G." last="Körschen">Heinz G. Körschen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff159"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0550 9586</institution-id>
<institution-id institution-id-type="GRID">grid.438114.b</institution-id>
<institution>Center of Advanced European Studies and Research (caesar) Bonn, Department: Molecular Sensory Systems,</institution>
</institution-wrap>
Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Bonn</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Oertner, Thomas G" sort="Oertner, Thomas G" uniqKey="Oertner T" first="Thomas G." last="Oertner">Thomas G. Oertner</name>
<affiliation wicri:level="1"><nlm:aff id="Aff158">University Medical Center Hamburg-Eppendorf, Center for Molecular Neurobiology Hamburg, Institute for Synaptic Physiology, Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University Medical Center Hamburg-Eppendorf, Center for Molecular Neurobiology Hamburg, Institute for Synaptic Physiology, Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hegemann, Peter" sort="Hegemann, Peter" uniqKey="Hegemann P" first="Peter" last="Hegemann">Peter Hegemann</name>
<affiliation wicri:level="1"><nlm:aff id="Aff157">Humboldt Universität zu Berlin, Institute for Biology, Experimental Biophysics, Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Humboldt Universität zu Berlin, Institute for Biology, Experimental Biophysics, Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmidt, Hannes" sort="Schmidt, Hannes" uniqKey="Schmidt H" first="Hannes" last="Schmidt">Hannes Schmidt</name>
<affiliation wicri:level="1"><nlm:aff id="Aff160"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfaculty Institute of Biochemistry,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff161"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1014 0849</institution-id>
<institution-id institution-id-type="GRID">grid.419491.0</institution-id>
<institution>Max Delbrück Center for Molecular Medicine in the Helmholtz Association,</institution>
</institution-wrap>
Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dickey, Deborah M" sort="Dickey, Deborah M" uniqKey="Dickey D" first="Deborah M." last="Dickey">Deborah M. Dickey</name>
<affiliation><nlm:aff id="Aff162"><institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Biochemistry,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, Minnesota USA</nlm:aff>
<wicri:noCountry code="subfield">Minnesota USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Dumoulin, Alexandre" sort="Dumoulin, Alexandre" uniqKey="Dumoulin A" first="Alexandre" last="Dumoulin">Alexandre Dumoulin</name>
<affiliation wicri:level="1"><nlm:aff id="Aff161"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1014 0849</institution-id>
<institution-id institution-id-type="GRID">grid.419491.0</institution-id>
<institution>Max Delbrück Center for Molecular Medicine in the Helmholtz Association,</institution>
</institution-wrap>
Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kuhn, Ralf" sort="Kuhn, Ralf" uniqKey="Kuhn R" first="Ralf" last="Kühn">Ralf Kühn</name>
<affiliation wicri:level="1"><nlm:aff id="Aff161"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1014 0849</institution-id>
<institution-id institution-id-type="GRID">grid.419491.0</institution-id>
<institution>Max Delbrück Center for Molecular Medicine in the Helmholtz Association,</institution>
</institution-wrap>
Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jaffe, Laurinda" sort="Jaffe, Laurinda" uniqKey="Jaffe L" first="Laurinda" last="Jaffe">Laurinda Jaffe</name>
<affiliation><nlm:aff id="Aff163"><institution-wrap><institution-id institution-id-type="ISNI">0000000419370394</institution-id>
<institution-id institution-id-type="GRID">grid.208078.5</institution-id>
<institution>Department of Cell Biology,</institution>
<institution>University of Connecticut Health Center,</institution>
</institution-wrap>
Farmington, Connecticut USA</nlm:aff>
<wicri:noCountry code="subfield">Connecticut USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Potter, Lincoln R" sort="Potter, Lincoln R" uniqKey="Potter L" first="Lincoln R." last="Potter">Lincoln R. Potter</name>
<affiliation><nlm:aff id="Aff162"><institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Biochemistry,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, Minnesota USA</nlm:aff>
<wicri:noCountry code="subfield">Minnesota USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Rathjen, Fritz G" sort="Rathjen, Fritz G" uniqKey="Rathjen F" first="Fritz G." last="Rathjen">Fritz G. Rathjen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff161"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1014 0849</institution-id>
<institution-id institution-id-type="GRID">grid.419491.0</institution-id>
<institution>Max Delbrück Center for Molecular Medicine in the Helmholtz Association,</institution>
</institution-wrap>
Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schobesberger, Sophie" sort="Schobesberger, Sophie" uniqKey="Schobesberger S" first="Sophie" last="Schobesberger">Sophie Schobesberger</name>
<affiliation wicri:level="1"><nlm:aff id="Aff164"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Institute of Experimental Cardiovascular Research,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>20246 Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wright, Peter" sort="Wright, Peter" uniqKey="Wright P" first="Peter" last="Wright">Peter Wright</name>
<affiliation><nlm:aff id="Aff165"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2113 8111</institution-id>
<institution-id institution-id-type="GRID">grid.7445.2</institution-id>
<institution>Department of Myocardial Function, Imperial College London, Hammersmith Hospital,</institution>
</institution-wrap>
W12 0NN, London, England UK</nlm:aff>
<wicri:noCountry code="subfield">England UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Poulet, Claire" sort="Poulet, Claire" uniqKey="Poulet C" first="Claire" last="Poulet">Claire Poulet</name>
<affiliation><nlm:aff id="Aff165"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2113 8111</institution-id>
<institution-id institution-id-type="GRID">grid.7445.2</institution-id>
<institution>Department of Myocardial Function, Imperial College London, Hammersmith Hospital,</institution>
</institution-wrap>
W12 0NN, London, England UK</nlm:aff>
<wicri:noCountry code="subfield">England UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mansfield, Catherine" sort="Mansfield, Catherine" uniqKey="Mansfield C" first="Catherine" last="Mansfield">Catherine Mansfield</name>
<affiliation><nlm:aff id="Aff165"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2113 8111</institution-id>
<institution-id institution-id-type="GRID">grid.7445.2</institution-id>
<institution>Department of Myocardial Function, Imperial College London, Hammersmith Hospital,</institution>
</institution-wrap>
W12 0NN, London, England UK</nlm:aff>
<wicri:noCountry code="subfield">England UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Friebe, Andreas" sort="Friebe, Andreas" uniqKey="Friebe A" first="Andreas" last="Friebe">Andreas Friebe</name>
<affiliation wicri:level="1"><nlm:aff id="Aff166"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Institute of Physiology,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
97070 Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>97070 Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Harding, Sian E" sort="Harding, Sian E" uniqKey="Harding S" first="Sian E." last="Harding">Sian E. Harding</name>
<affiliation><nlm:aff id="Aff165"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2113 8111</institution-id>
<institution-id institution-id-type="GRID">grid.7445.2</institution-id>
<institution>Department of Myocardial Function, Imperial College London, Hammersmith Hospital,</institution>
</institution-wrap>
W12 0NN, London, England UK</nlm:aff>
<wicri:noCountry code="subfield">England UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Nikolaev, Viacheslav O" sort="Nikolaev, Viacheslav O" uniqKey="Nikolaev V" first="Viacheslav O." last="Nikolaev">Viacheslav O. Nikolaev</name>
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<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Institute of Experimental Cardiovascular Research,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>20246 Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gorelik, Julia" sort="Gorelik, Julia" uniqKey="Gorelik J" first="Julia" last="Gorelik">Julia Gorelik</name>
<affiliation><nlm:aff id="Aff165"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2113 8111</institution-id>
<institution-id institution-id-type="GRID">grid.7445.2</institution-id>
<institution>Department of Myocardial Function, Imperial College London, Hammersmith Hospital,</institution>
</institution-wrap>
W12 0NN, London, England UK</nlm:aff>
<wicri:noCountry code="subfield">England UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kollau, Alexander" sort="Kollau, Alexander" uniqKey="Kollau A" first="Alexander" last="Kollau">Alexander Kollau</name>
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<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
A 8010 Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A 8010 Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Opelt, Marissa" sort="Opelt, Marissa" uniqKey="Opelt M" first="Marissa" last="Opelt">Marissa Opelt</name>
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<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
A 8010 Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A 8010 Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wolkart, Gerald" sort="Wolkart, Gerald" uniqKey="Wolkart G" first="Gerald" last="Wölkart">Gerald Wölkart</name>
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<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
A 8010 Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A 8010 Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gorren, Antonius C F" sort="Gorren, Antonius C F" uniqKey="Gorren A" first="Antonius C. F." last="Gorren">Antonius C. F. Gorren</name>
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<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
A 8010 Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A 8010 Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Russwurm, Michael" sort="Russwurm, Michael" uniqKey="Russwurm M" first="Michael" last="Russwurm">Michael Russwurm</name>
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<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>Ruhr University Bochum,</institution>
</institution-wrap>
D 44780 Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>D 44780 Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koesling, Doris" sort="Koesling, Doris" uniqKey="Koesling D" first="Doris" last="Koesling">Doris Koesling</name>
<affiliation wicri:level="1"><nlm:aff id="Aff168"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>Ruhr University Bochum,</institution>
</institution-wrap>
D 44780 Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>D 44780 Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schrammel, Astrid" sort="Schrammel, Astrid" uniqKey="Schrammel A" first="Astrid" last="Schrammel">Astrid Schrammel</name>
<affiliation wicri:level="1"><nlm:aff id="Aff167"><institution-wrap><institution-id institution-id-type="ISNI">0000000121539003</institution-id>
<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
A 8010 Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A 8010 Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mayer, Bernd" sort="Mayer, Bernd" uniqKey="Mayer B" first="Bernd" last="Mayer">Bernd Mayer</name>
<affiliation wicri:level="1"><nlm:aff id="Aff167"><institution-wrap><institution-id institution-id-type="ISNI">0000000121539003</institution-id>
<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
A 8010 Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A 8010 Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schwaerzer, Gerburg K" sort="Schwaerzer, Gerburg K" uniqKey="Schwaerzer G" first="Gerburg K." last="Schwaerzer">Gerburg K. Schwaerzer</name>
<affiliation wicri:level="1"><nlm:aff id="Aff169"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2181 7878</institution-id>
<institution-id institution-id-type="GRID">grid.47840.3f</institution-id>
<institution>Department of Medicine,</institution>
<institution>University of California San Diego,</institution>
</institution-wrap>
La Jolla, California, 92093 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>La Jolla, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Casteel, Darren E" sort="Casteel, Darren E" uniqKey="Casteel D" first="Darren E." last="Casteel">Darren E. Casteel</name>
<affiliation wicri:level="1"><nlm:aff id="Aff169"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2181 7878</institution-id>
<institution-id institution-id-type="GRID">grid.47840.3f</institution-id>
<institution>Department of Medicine,</institution>
<institution>University of California San Diego,</institution>
</institution-wrap>
La Jolla, California, 92093 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>La Jolla, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dalton, Nancy D" sort="Dalton, Nancy D" uniqKey="Dalton N" first="Nancy D." last="Dalton">Nancy D. Dalton</name>
<affiliation wicri:level="1"><nlm:aff id="Aff169"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2181 7878</institution-id>
<institution-id institution-id-type="GRID">grid.47840.3f</institution-id>
<institution>Department of Medicine,</institution>
<institution>University of California San Diego,</institution>
</institution-wrap>
La Jolla, California, 92093 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>La Jolla, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gu, Yusu" sort="Gu, Yusu" uniqKey="Gu Y" first="Yusu" last="Gu">Yusu Gu</name>
<affiliation wicri:level="1"><nlm:aff id="Aff169"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2181 7878</institution-id>
<institution-id institution-id-type="GRID">grid.47840.3f</institution-id>
<institution>Department of Medicine,</institution>
<institution>University of California San Diego,</institution>
</institution-wrap>
La Jolla, California, 92093 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>La Jolla, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhuang, Shunhui" sort="Zhuang, Shunhui" uniqKey="Zhuang S" first="Shunhui" last="Zhuang">Shunhui Zhuang</name>
<affiliation wicri:level="1"><nlm:aff id="Aff169"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2181 7878</institution-id>
<institution-id institution-id-type="GRID">grid.47840.3f</institution-id>
<institution>Department of Medicine,</institution>
<institution>University of California San Diego,</institution>
</institution-wrap>
La Jolla, California, 92093 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>La Jolla, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Milewicz, Dianna M" sort="Milewicz, Dianna M" uniqKey="Milewicz D" first="Dianna M." last="Milewicz">Dianna M. Milewicz</name>
<affiliation wicri:level="2"><nlm:aff id="Aff170"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9206 2401</institution-id>
<institution-id institution-id-type="GRID">grid.267308.8</institution-id>
<institution>Division of Medical Genetics and Cardiology, Department of Internal Medicine,</institution>
<institution>The University of Texas Health Science Center at Houston,</institution>
</institution-wrap>
Houston, Texas 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Peterson, Kirk L" sort="Peterson, Kirk L" uniqKey="Peterson K" first="Kirk L." last="Peterson">Kirk L. Peterson</name>
<affiliation wicri:level="2"><nlm:aff id="Aff170"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9206 2401</institution-id>
<institution-id institution-id-type="GRID">grid.267308.8</institution-id>
<institution>Division of Medical Genetics and Cardiology, Department of Internal Medicine,</institution>
<institution>The University of Texas Health Science Center at Houston,</institution>
</institution-wrap>
Houston, Texas 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Pilz, Renate" sort="Pilz, Renate" uniqKey="Pilz R" first="Renate" last="Pilz">Renate Pilz</name>
<affiliation wicri:level="1"><nlm:aff id="Aff169"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2181 7878</institution-id>
<institution-id institution-id-type="GRID">grid.47840.3f</institution-id>
<institution>Department of Medicine,</institution>
<institution>University of California San Diego,</institution>
</institution-wrap>
La Jolla, California, 92093 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>La Jolla, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schwiering, Fabian" sort="Schwiering, Fabian" uniqKey="Schwiering F" first="Fabian" last="Schwiering">Fabian Schwiering</name>
<affiliation wicri:level="1"><nlm:aff id="Aff171"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aue, Annemarie" sort="Aue, Annemarie" uniqKey="Aue A" first="Annemarie" last="Aue">Annemarie Aue</name>
<affiliation wicri:level="1"><nlm:aff id="Aff171"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Groneberg, Dieter" sort="Groneberg, Dieter" uniqKey="Groneberg D" first="Dieter" last="Groneberg">Dieter Groneberg</name>
<affiliation wicri:level="1"><nlm:aff id="Aff171"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Friebe, Andreas" sort="Friebe, Andreas" uniqKey="Friebe A" first="Andreas" last="Friebe">Andreas Friebe</name>
<affiliation wicri:level="1"><nlm:aff id="Aff171"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Argyriou, Aikaterini I" sort="Argyriou, Aikaterini I" uniqKey="Argyriou A" first="Aikaterini I." last="Argyriou">Aikaterini I. Argyriou</name>
<affiliation wicri:level="1"><nlm:aff id="Aff172"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0576 5395</institution-id>
<institution-id institution-id-type="GRID">grid.11047.33</institution-id>
<institution>Department of Pharmacy,</institution>
<institution>University of Patras,</institution>
</institution-wrap>
GR-26504 Patras, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>GR-26504 Patras</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Makrynitsa, Garyfalia" sort="Makrynitsa, Garyfalia" uniqKey="Makrynitsa G" first="Garyfalia" last="Makrynitsa">Garyfalia Makrynitsa</name>
<affiliation wicri:level="1"><nlm:aff id="Aff172"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0576 5395</institution-id>
<institution-id institution-id-type="GRID">grid.11047.33</institution-id>
<institution>Department of Pharmacy,</institution>
<institution>University of Patras,</institution>
</institution-wrap>
GR-26504 Patras, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>GR-26504 Patras</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alexandropoulos, Ioannis I" sort="Alexandropoulos, Ioannis I" uniqKey="Alexandropoulos I" first="Ioannis I." last="Alexandropoulos">Ioannis I. Alexandropoulos</name>
<affiliation wicri:level="1"><nlm:aff id="Aff172"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0576 5395</institution-id>
<institution-id institution-id-type="GRID">grid.11047.33</institution-id>
<institution>Department of Pharmacy,</institution>
<institution>University of Patras,</institution>
</institution-wrap>
GR-26504 Patras, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>GR-26504 Patras</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stamopoulou, Andriana" sort="Stamopoulou, Andriana" uniqKey="Stamopoulou A" first="Andriana" last="Stamopoulou">Andriana Stamopoulou</name>
<affiliation wicri:level="1"><nlm:aff id="Aff172"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0576 5395</institution-id>
<institution-id institution-id-type="GRID">grid.11047.33</institution-id>
<institution>Department of Pharmacy,</institution>
<institution>University of Patras,</institution>
</institution-wrap>
GR-26504 Patras, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>GR-26504 Patras</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bantzi, Marina" sort="Bantzi, Marina" uniqKey="Bantzi M" first="Marina" last="Bantzi">Marina Bantzi</name>
<affiliation wicri:level="1"><nlm:aff id="Aff173"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2230 9752</institution-id>
<institution-id institution-id-type="GRID">grid.9647.c</institution-id>
<institution>Institute of Organic Chemistry,</institution>
<institution>Leipzig University,</institution>
</institution-wrap>
D-04103 Leipzig, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>D-04103 Leipzig</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Giannis, Athanassios" sort="Giannis, Athanassios" uniqKey="Giannis A" first="Athanassios" last="Giannis">Athanassios Giannis</name>
<affiliation wicri:level="1"><nlm:aff id="Aff173"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2230 9752</institution-id>
<institution-id institution-id-type="GRID">grid.9647.c</institution-id>
<institution>Institute of Organic Chemistry,</institution>
<institution>Leipzig University,</institution>
</institution-wrap>
D-04103 Leipzig, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>D-04103 Leipzig</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Topouzis, Stavros" sort="Topouzis, Stavros" uniqKey="Topouzis S" first="Stavros" last="Topouzis">Stavros Topouzis</name>
<affiliation wicri:level="1"><nlm:aff id="Aff172"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0576 5395</institution-id>
<institution-id institution-id-type="GRID">grid.11047.33</institution-id>
<institution>Department of Pharmacy,</institution>
<institution>University of Patras,</institution>
</institution-wrap>
GR-26504 Patras, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>GR-26504 Patras</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Papapetropoulos, Andreas" sort="Papapetropoulos, Andreas" uniqKey="Papapetropoulos A" first="Andreas" last="Papapetropoulos">Andreas Papapetropoulos</name>
<affiliation wicri:level="1"><nlm:aff id="Aff172"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0576 5395</institution-id>
<institution-id institution-id-type="GRID">grid.11047.33</institution-id>
<institution>Department of Pharmacy,</institution>
<institution>University of Patras,</institution>
</institution-wrap>
GR-26504 Patras, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>GR-26504 Patras</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff174"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2155 0800</institution-id>
<institution-id institution-id-type="GRID">grid.5216.0</institution-id>
<institution>School of Health Sciences, Faculty of Pharmacy,</institution>
<institution>University of Athens,</institution>
</institution-wrap>
GR-15 771 Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>GR-15 771 Athens</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Spyroulias, Georgios A" sort="Spyroulias, Georgios A" uniqKey="Spyroulias G" first="Georgios A." last="Spyroulias">Georgios A. Spyroulias</name>
<affiliation wicri:level="1"><nlm:aff id="Aff172"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0576 5395</institution-id>
<institution-id institution-id-type="GRID">grid.11047.33</institution-id>
<institution>Department of Pharmacy,</institution>
<institution>University of Patras,</institution>
</institution-wrap>
GR-26504 Patras, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>GR-26504 Patras</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stuehr, Dennis J" sort="Stuehr, Dennis J" uniqKey="Stuehr D" first="Dennis J." last="Stuehr">Dennis J. Stuehr</name>
<affiliation wicri:level="2"><nlm:aff id="Aff175"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0675 4725</institution-id>
<institution-id institution-id-type="GRID">grid.239578.2</institution-id>
<institution>Department of Pathobiology, Lerner Research Institute, Cleveland Clinic,</institution>
</institution-wrap>
Cleveland, Ohio 44195 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ghosh, Arnab" sort="Ghosh, Arnab" uniqKey="Ghosh A" first="Arnab" last="Ghosh">Arnab Ghosh</name>
<affiliation wicri:level="2"><nlm:aff id="Aff175"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0675 4725</institution-id>
<institution-id institution-id-type="GRID">grid.239578.2</institution-id>
<institution>Department of Pathobiology, Lerner Research Institute, Cleveland Clinic,</institution>
</institution-wrap>
Cleveland, Ohio 44195 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dai, Yue" sort="Dai, Yue" uniqKey="Dai Y" first="Yue" last="Dai">Yue Dai</name>
<affiliation wicri:level="2"><nlm:aff id="Aff175"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0675 4725</institution-id>
<institution-id institution-id-type="GRID">grid.239578.2</institution-id>
<institution>Department of Pathobiology, Lerner Research Institute, Cleveland Clinic,</institution>
</institution-wrap>
Cleveland, Ohio 44195 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Misra, Saurav" sort="Misra, Saurav" uniqKey="Misra S" first="Saurav" last="Misra">Saurav Misra</name>
<affiliation wicri:level="2"><nlm:aff id="Aff176"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0737 1259</institution-id>
<institution-id institution-id-type="GRID">grid.36567.31</institution-id>
<institution>Kansas State University,</institution>
</institution-wrap>
Manhattan, Kansas 66506 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kansas</region>
</placeName>
<wicri:cityArea>Manhattan</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tchernychev, Boris" sort="Tchernychev, Boris" uniqKey="Tchernychev B" first="Boris" last="Tchernychev">Boris Tchernychev</name>
<affiliation wicri:level="2"><nlm:aff id="Aff177"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jung, Joon" sort="Jung, Joon" uniqKey="Jung J" first="Joon" last="Jung">Joon Jung</name>
<affiliation wicri:level="2"><nlm:aff id="Aff177"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Liu, Guang" sort="Liu, Guang" uniqKey="Liu G" first="Guang" last="Liu">Guang Liu</name>
<affiliation wicri:level="2"><nlm:aff id="Aff177"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Silos Santiago, Inmaculada" sort="Silos Santiago, Inmaculada" uniqKey="Silos Santiago I" first="Inmaculada" last="Silos-Santiago">Inmaculada Silos-Santiago</name>
<affiliation wicri:level="2"><nlm:aff id="Aff178">Decibel Therapeutics, Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Decibel Therapeutics, Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hannig, Gerhard" sort="Hannig, Gerhard" uniqKey="Hannig G" first="Gerhard" last="Hannig">Gerhard Hannig</name>
<affiliation wicri:level="2"><nlm:aff id="Aff177"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dao, Vu Thao Vi" sort="Dao, Vu Thao Vi" uniqKey="Dao V" first="Vu Thao-Vi" last="Dao">Vu Thao-Vi Dao</name>
<affiliation wicri:level="1"><nlm:aff id="Aff179"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0481 6099</institution-id>
<institution-id institution-id-type="GRID">grid.5012.6</institution-id>
<institution>Department for Pharmacology and Personalized Medicine, CARIM, FHML,</institution>
<institution>Maastricht University,</institution>
</institution-wrap>
Maastricht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Maastricht</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff180"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1941 7111</institution-id>
<institution-id institution-id-type="GRID">grid.5802.f</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>Johannes Gutenberg University,</institution>
</institution-wrap>
Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Mainz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Deile, Martin" sort="Deile, Martin" uniqKey="Deile M" first="Martin" last="Deile">Martin Deile</name>
<affiliation wicri:level="1"><nlm:aff id="Aff181">Asklepios-Klinik Radeberg, Dresden, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Asklepios-Klinik Radeberg, Dresden</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nedvetsky, Pavel I" sort="Nedvetsky, Pavel I" uniqKey="Nedvetsky P" first="Pavel I." last="Nedvetsky">Pavel I. Nedvetsky</name>
<affiliation wicri:level="1"><nlm:aff id="Aff182"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0668 7884</institution-id>
<institution-id institution-id-type="GRID">grid.5596.f</institution-id>
<institution>Vesalius Research Center,</institution>
<institution>Katholieke Universiteit Leuven,</institution>
</institution-wrap>
Leuven, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Leuven</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guldner, Andreas" sort="Guldner, Andreas" uniqKey="Guldner A" first="Andreas" last="Güldner">Andreas Güldner</name>
<affiliation wicri:level="1"><nlm:aff id="Aff183"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2111 7257</institution-id>
<institution-id institution-id-type="GRID">grid.4488.0</institution-id>
<institution>Residency Anaesthesiology, Department of Anaesthesiology und Critical Care Medicine,</institution>
<institution>Technische Universität,</institution>
</institution-wrap>
Dresden, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dresden</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ibarra Alvarado, Cesar" sort="Ibarra Alvarado, Cesar" uniqKey="Ibarra Alvarado C" first="César" last="Ibarra-Alvarado">César Ibarra-Alvarado</name>
<affiliation wicri:level="1"><nlm:aff id="Aff184"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2207 2097</institution-id>
<institution-id institution-id-type="GRID">grid.412861.8</institution-id>
<institution>Facultad de Química, Universidad Autónoma de Querétaro,</institution>
</institution-wrap>
Santiago de Querétaro, Mexico</nlm:aff>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>Santiago de Querétaro</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Godecke, Axel" sort="Godecke, Axel" uniqKey="Godecke A" first="Axel" last="Gödecke">Axel Gödecke</name>
<affiliation wicri:level="1"><nlm:aff id="Aff185"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2176 9917</institution-id>
<institution-id institution-id-type="GRID">grid.411327.2</institution-id>
<institution>Institut für Herz- und Kreislaufphysiologie Heinrich-Heine-Universität,</institution>
</institution-wrap>
Düsseldorf, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Düsseldorf</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmidt, Harald H H W" sort="Schmidt, Harald H H W" uniqKey="Schmidt H" first="Harald H. H. W." last="Schmidt">Harald H. H. W. Schmidt</name>
<affiliation wicri:level="1"><nlm:aff id="Aff179"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0481 6099</institution-id>
<institution-id institution-id-type="GRID">grid.5012.6</institution-id>
<institution>Department for Pharmacology and Personalized Medicine, CARIM, FHML,</institution>
<institution>Maastricht University,</institution>
</institution-wrap>
Maastricht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Maastricht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vachaviolos, Angelos" sort="Vachaviolos, Angelos" uniqKey="Vachaviolos A" first="Angelos" last="Vachaviolos">Angelos Vachaviolos</name>
<affiliation wicri:level="1"><nlm:aff id="Aff186"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gerling, Andrea" sort="Gerling, Andrea" uniqKey="Gerling A" first="Andrea" last="Gerling">Andrea Gerling</name>
<affiliation wicri:level="1"><nlm:aff id="Aff186"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thunemann, Martin" sort="Thunemann, Martin" uniqKey="Thunemann M" first="Martin" last="Thunemann">Martin Thunemann</name>
<affiliation wicri:level="1"><nlm:aff id="Aff186"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lutz, Stefan Z" sort="Lutz, Stefan Z" uniqKey="Lutz S" first="Stefan Z." last="Lutz">Stefan Z. Lutz</name>
<affiliation wicri:level="1"><nlm:aff id="Aff187"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="H Ring, Hans Ulrich" sort="H Ring, Hans Ulrich" uniqKey="H Ring H" first="Hans-Ulrich" last="H Ring">Hans-Ulrich H Ring</name>
<affiliation wicri:level="1"><nlm:aff id="Aff187"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kruger, Marcel A" sort="Kruger, Marcel A" uniqKey="Kruger M" first="Marcel A." last="Krüger">Marcel A. Krüger</name>
<affiliation wicri:level="1"><nlm:aff id="Aff188"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pichler, Bernd J" sort="Pichler, Bernd J" uniqKey="Pichler B" first="Bernd J." last="Pichler">Bernd J. Pichler</name>
<affiliation wicri:level="1"><nlm:aff id="Aff188"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Shipston, Michael J" sort="Shipston, Michael J" uniqKey="Shipston M" first="Michael J." last="Shipston">Michael J. Shipston</name>
<affiliation><nlm:aff id="Aff189"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7988</institution-id>
<institution-id institution-id-type="GRID">grid.4305.2</institution-id>
<institution>Centre for Integrative Physiology, School of Biomedical Science, Hugh Robson Building,</institution>
<institution>University of Edinburgh,</institution>
</institution-wrap>
Edinburgh, Scotland EH8 9XD UK</nlm:aff>
<wicri:noCountry code="subfield">Scotland EH8 9XD UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Feil, Susanne" sort="Feil, Susanne" uniqKey="Feil S" first="Susanne" last="Feil">Susanne Feil</name>
<affiliation wicri:level="1"><nlm:aff id="Aff186"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Feil, Robert" sort="Feil, Robert" uniqKey="Feil R" first="Robert" last="Feil">Robert Feil</name>
<affiliation wicri:level="1"><nlm:aff id="Aff186"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vandenwijngaert, Sara" sort="Vandenwijngaert, Sara" uniqKey="Vandenwijngaert S" first="Sara" last="Vandenwijngaert">Sara Vandenwijngaert</name>
<affiliation><nlm:aff id="Aff190"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School,</institution>
</institution-wrap>
Boston, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ledsky, Clara D" sort="Ledsky, Clara D" uniqKey="Ledsky C" first="Clara D." last="Ledsky">Clara D. Ledsky</name>
<affiliation><nlm:aff id="Aff190"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School,</institution>
</institution-wrap>
Boston, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Agha, Obiajulu" sort="Agha, Obiajulu" uniqKey="Agha O" first="Obiajulu" last="Agha">Obiajulu Agha</name>
<affiliation><nlm:aff id="Aff190"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School,</institution>
</institution-wrap>
Boston, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Hu, Dongjian" sort="Hu, Dongjian" uniqKey="Hu D" first="Dongjian" last="Hu">Dongjian Hu</name>
<affiliation><nlm:aff id="Aff191"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital and Harvard Medical School,</institution>
</institution-wrap>
Boston, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Domian, Ibrahim J" sort="Domian, Ibrahim J" uniqKey="Domian I" first="Ibrahim J." last="Domian">Ibrahim J. Domian</name>
<affiliation><nlm:aff id="Aff191"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital and Harvard Medical School,</institution>
</institution-wrap>
Boston, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff192"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Harvard Stem Cell Institute,</institution>
</institution-wrap>
Cambridge, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Buys, Emmanuel S" sort="Buys, Emmanuel S" uniqKey="Buys E" first="Emmanuel S." last="Buys">Emmanuel S. Buys</name>
<affiliation><nlm:aff id="Aff190"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School,</institution>
</institution-wrap>
Boston, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Newton Cheh, Christopher" sort="Newton Cheh, Christopher" uniqKey="Newton Cheh C" first="Christopher" last="Newton-Cheh">Christopher Newton-Cheh</name>
<affiliation><nlm:aff id="Aff191"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital and Harvard Medical School,</institution>
</institution-wrap>
Boston, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff193"><institution-wrap><institution-id institution-id-type="GRID">grid.66859.34</institution-id>
<institution>Program in Medical and Population Genetics, Broad Institute,</institution>
</institution-wrap>
Cambridge, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff194"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School,</institution>
</institution-wrap>
Boston, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bloch, Donald B" sort="Bloch, Donald B" uniqKey="Bloch D" first="Donald B." last="Bloch">Donald B. Bloch</name>
<affiliation><nlm:aff id="Aff190"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School,</institution>
</institution-wrap>
Boston, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff195"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School,</institution>
</institution-wrap>
Boston, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Voussen, Barbara" sort="Voussen, Barbara" uniqKey="Voussen B" first="Barbara" last="Voussen">Barbara Voussen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff196"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
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<institution>Physiologisches Institut,</institution>
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Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
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<institution>Physiologisches Institut,</institution>
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Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
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<author><name sortKey="Mauro, Nadine" sort="Mauro, Nadine" uniqKey="Mauro N" first="Nadine" last="Mauro">Nadine Mauro</name>
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<institution>Physiologisches Institut,</institution>
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Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
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<author><name sortKey="Keppler, Jonas" sort="Keppler, Jonas" uniqKey="Keppler J" first="Jonas" last="Keppler">Jonas Keppler</name>
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Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
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<author><name sortKey="Friebe, Andreas" sort="Friebe, Andreas" uniqKey="Friebe A" first="Andreas" last="Friebe">Andreas Friebe</name>
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Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
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<author><name sortKey="Ferreira, Wilson A" sort="Ferreira, Wilson A" uniqKey="Ferreira W" first="Wilson A." last="Ferreira">Wilson A. Ferreira</name>
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Sao Paolo, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Sao Paolo</wicri:regionArea>
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</author>
<author><name sortKey="Chweih, Hanan" sort="Chweih, Hanan" uniqKey="Chweih H" first="Hanan" last="Chweih">Hanan Chweih</name>
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<institution>Hematology Centre, School of Medical Sciences,</institution>
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Sao Paolo, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Sao Paolo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brito, Pamela L" sort="Brito, Pamela L" uniqKey="Brito P" first="Pamela L." last="Brito">Pamela L. Brito</name>
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Sao Paolo, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Sao Paolo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Almeida, Camila B" sort="Almeida, Camila B" uniqKey="Almeida C" first="Camila B." last="Almeida">Camila B. Almeida</name>
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Sao Paolo, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Sao Paolo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Penteado, Carla F F" sort="Penteado, Carla F F" uniqKey="Penteado C" first="Carla F. F." last="Penteado">Carla F. F. Penteado</name>
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Sao Paolo, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Sao Paolo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Saad, Sara S O" sort="Saad, Sara S O" uniqKey="Saad S" first="Sara S. O." last="Saad">Sara S. O. Saad</name>
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Sao Paolo, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Sao Paolo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Costa, Fernando F" sort="Costa, Fernando F" uniqKey="Costa F" first="Fernando F." last="Costa">Fernando F. Costa</name>
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<institution-id institution-id-type="GRID">grid.411087.b</institution-id>
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Sao Paolo, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Sao Paolo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Frenette, Paul S" sort="Frenette, Paul S" uniqKey="Frenette P" first="Paul S." last="Frenette">Paul S. Frenette</name>
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<institution>Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine,</institution>
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Bronx, NY USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Bronx</wicri:cityArea>
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<author><name sortKey="Brockschnieder, Damian" sort="Brockschnieder, Damian" uniqKey="Brockschnieder D" first="Damian" last="Brockschnieder">Damian Brockschnieder</name>
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<institution>Bayer AG, Pharmaceuticals - Drug Discovery,</institution>
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Wuppertal, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Wuppertal</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stasch, Johannes Peter" sort="Stasch, Johannes Peter" uniqKey="Stasch J" first="Johannes-Peter" last="Stasch">Johannes-Peter Stasch</name>
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<institution>Bayer AG, Pharmaceuticals - Drug Discovery,</institution>
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Wuppertal, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Wuppertal</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sandner, Peter" sort="Sandner, Peter" uniqKey="Sandner P" first="Peter" last="Sandner">Peter Sandner</name>
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<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Bayer AG, Pharmaceuticals - Drug Discovery,</institution>
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Wuppertal, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Wuppertal</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Conran, Nicola" sort="Conran, Nicola" uniqKey="Conran N" first="Nicola" last="Conran">Nicola Conran</name>
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Sao Paolo, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Sao Paolo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zimmer, Daniel P" sort="Zimmer, Daniel P" uniqKey="Zimmer D" first="Daniel P." last="Zimmer">Daniel P. Zimmer</name>
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Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tobin, Jenny" sort="Tobin, Jenny" uniqKey="Tobin J" first="Jenny" last="Tobin">Jenny Tobin</name>
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<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
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Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Shea, Courtney" sort="Shea, Courtney" uniqKey="Shea C" first="Courtney" last="Shea">Courtney Shea</name>
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<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
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Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sarno, Renee" sort="Sarno, Renee" uniqKey="Sarno R" first="Renee" last="Sarno">Renee Sarno</name>
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<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
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Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Long, Kimberly" sort="Long, Kimberly" uniqKey="Long K" first="Kimberly" last="Long">Kimberly Long</name>
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<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
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Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jacobson, Sarah" sort="Jacobson, Sarah" uniqKey="Jacobson S" first="Sarah" last="Jacobson">Sarah Jacobson</name>
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<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
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</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tang, Kim" sort="Tang, Kim" uniqKey="Tang K" first="Kim" last="Tang">Kim Tang</name>
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<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
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Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Germano, Peter" sort="Germano, Peter" uniqKey="Germano P" first="Peter" last="Germano">Peter Germano</name>
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<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
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Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wakefield, James" sort="Wakefield, James" uniqKey="Wakefield J" first="James" last="Wakefield">James Wakefield</name>
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<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
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Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Banijamali, Ali" sort="Banijamali, Ali" uniqKey="Banijamali A" first="Ali" last="Banijamali">Ali Banijamali</name>
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<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
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Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Im, G Yoon Jamie" sort="Im, G Yoon Jamie" uniqKey="Im G" first="G-Yoon Jamie" last="Im">G-Yoon Jamie Im</name>
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<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
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Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
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<author><name sortKey="Sheppeck, James E" sort="Sheppeck, James E" uniqKey="Sheppeck J" first="James E." last="Sheppeck">James E. Sheppeck</name>
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Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
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<author><name sortKey="Profy, Albert T" sort="Profy, Albert T" uniqKey="Profy A" first="Albert T." last="Profy">Albert T. Profy</name>
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Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Todd Milne, G" sort="Todd Milne, G" uniqKey="Todd Milne G" first="G." last="Todd Milne">G. Todd Milne</name>
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Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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</placeName>
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<author><name sortKey="Currie, Mark G" sort="Currie, Mark G" uniqKey="Currie M" first="Mark G." last="Currie">Mark G. Currie</name>
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Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
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</affiliation>
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<author><name sortKey="Masferrer, Jaime L" sort="Masferrer, Jaime L" uniqKey="Masferrer J" first="Jaime L." last="Masferrer">Jaime L. Masferrer</name>
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Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications</title>
<author><name sortKey="Todd Milne, G" sort="Todd Milne, G" uniqKey="Todd Milne G" first="G." last="Todd Milne">G. Todd Milne</name>
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Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
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<author><name sortKey="Sandner, Peter" sort="Sandner, Peter" uniqKey="Sandner P" first="Peter" last="Sandner">Peter Sandner</name>
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<institution>Bayer AG, Drug Discovery - Cardiovascular Research,</institution>
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Wuppertal, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
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</author>
<author><name sortKey="Lincoln, Kathleen A" sort="Lincoln, Kathleen A" uniqKey="Lincoln K" first="Kathleen A." last="Lincoln">Kathleen A. Lincoln</name>
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<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals,</institution>
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Ridgefield, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
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<author><name sortKey="Harrison, Paul C" sort="Harrison, Paul C" uniqKey="Harrison P" first="Paul C." last="Harrison">Paul C. Harrison</name>
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<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals,</institution>
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Ridgefield, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
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<wicri:cityArea>Ridgefield</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Chen, Hongxing" sort="Chen, Hongxing" uniqKey="Chen H" first="Hongxing" last="Chen">Hongxing Chen</name>
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<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals,</institution>
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Ridgefield, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
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<wicri:cityArea>Ridgefield</wicri:cityArea>
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</author>
<author><name sortKey="Wang, Hong" sort="Wang, Hong" uniqKey="Wang H" first="Hong" last="Wang">Hong Wang</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1312 9717</institution-id>
<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals,</institution>
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Ridgefield, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
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<wicri:cityArea>Ridgefield</wicri:cityArea>
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</author>
<author><name sortKey="Clifford, Holly" sort="Clifford, Holly" uniqKey="Clifford H" first="Holly" last="Clifford">Holly Clifford</name>
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<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals,</institution>
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Ridgefield, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Ridgefield</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Qian, Hu Sheng" sort="Qian, Hu Sheng" uniqKey="Qian H" first="Hu Sheng" last="Qian">Hu Sheng Qian</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1312 9717</institution-id>
<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals,</institution>
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Ridgefield, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Ridgefield</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wong, Diane" sort="Wong, Diane" uniqKey="Wong D" first="Diane" last="Wong">Diane Wong</name>
<affiliation wicri:level="2"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1312 9717</institution-id>
<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Small Molecule Drug Research, Boehringer Ingelheim Pharmaceuticals,</institution>
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Ridgefield, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Ridgefield</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sarko, Chris" sort="Sarko, Chris" uniqKey="Sarko C" first="Chris" last="Sarko">Chris Sarko</name>
<affiliation wicri:level="2"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1312 9717</institution-id>
<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Small Molecule Drug Research, Boehringer Ingelheim Pharmaceuticals,</institution>
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Ridgefield, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Ridgefield</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Fryer, Ryan" sort="Fryer, Ryan" uniqKey="Fryer R" first="Ryan" last="Fryer">Ryan Fryer</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1312 9717</institution-id>
<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals,</institution>
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Ridgefield, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Ridgefield</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Richman, Jeremy" sort="Richman, Jeremy" uniqKey="Richman J" first="Jeremy" last="Richman">Jeremy Richman</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1312 9717</institution-id>
<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals,</institution>
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Ridgefield, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Ridgefield</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Reinhart, Glenn A" sort="Reinhart, Glenn A" uniqKey="Reinhart G" first="Glenn A." last="Reinhart">Glenn A. Reinhart</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1312 9717</institution-id>
<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals,</institution>
</institution-wrap>
Ridgefield, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Ridgefield</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Boustany, Carine M" sort="Boustany, Carine M" uniqKey="Boustany C" first="Carine M." last="Boustany">Carine M. Boustany</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1312 9717</institution-id>
<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals,</institution>
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Ridgefield, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Ridgefield</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Pullen, Steven S" sort="Pullen, Steven S" uniqKey="Pullen S" first="Steven S." last="Pullen">Steven S. Pullen</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1312 9717</institution-id>
<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals,</institution>
</institution-wrap>
Ridgefield, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Ridgefield</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Andresen, Henriette" sort="Andresen, Henriette" uniqKey="Andresen H" first="Henriette" last="Andresen">Henriette Andresen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Institute of Experimental Medical Research,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Moltzau, Lise Roman" sort="Moltzau, Lise Roman" uniqKey="Moltzau L" first="Lise Román" last="Moltzau">Lise Román Moltzau</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cataliotti, Alessandro" sort="Cataliotti, Alessandro" uniqKey="Cataliotti A" first="Alessandro" last="Cataliotti">Alessandro Cataliotti</name>
<affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Institute of Experimental Medical Research,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Levy, Finn Olav" sort="Levy, Finn Olav" uniqKey="Levy F" first="Finn Olav" last="Levy">Finn Olav Levy</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lukowski, Robert" sort="Lukowski, Robert" uniqKey="Lukowski R" first="Robert" last="Lukowski">Robert Lukowski</name>
<affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Pharmacology, Toxicology and Clinical Pharmacy,</institution>
<institution>Institute of Pharmacy, University of Tuebingen,</institution>
</institution-wrap>
Tuebingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tuebingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Frankenreiter, Sandra" sort="Frankenreiter, Sandra" uniqKey="Frankenreiter S" first="Sandra" last="Frankenreiter">Sandra Frankenreiter</name>
<affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Pharmacology, Toxicology and Clinical Pharmacy,</institution>
<institution>Institute of Pharmacy, University of Tuebingen,</institution>
</institution-wrap>
Tuebingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tuebingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Friebe, Andreas" sort="Friebe, Andreas" uniqKey="Friebe A" first="Andreas" last="Friebe">Andreas Friebe</name>
<affiliation wicri:level="1"><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Calamaras, Timothy" sort="Calamaras, Timothy" uniqKey="Calamaras T" first="Timothy" last="Calamaras">Timothy Calamaras</name>
<affiliation wicri:level="2"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8934 4045</institution-id>
<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Molecular Cardiology Research Institute, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Baumgartner, Robert" sort="Baumgartner, Robert" uniqKey="Baumgartner R" first="Robert" last="Baumgartner">Robert Baumgartner</name>
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<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Molecular Cardiology Research Institute, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff11"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0650 7433</institution-id>
<institution-id institution-id-type="GRID">grid.412689.0</institution-id>
<institution>Present Affiliation: Division of Cardiology,</institution>
<institution>University of Pittsburgh Medical Center,</institution>
</institution-wrap>
Pittsburgh, Pennsylvania ,15224 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Pittsburgh, Pennsylvania </wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mclaughlin, Angela" sort="Mclaughlin, Angela" uniqKey="Mclaughlin A" first="Angela" last="Mclaughlin">Angela Mclaughlin</name>
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<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Molecular Cardiology Research Institute, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff12"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9094</institution-id>
<institution-id institution-id-type="GRID">grid.40263.33</institution-id>
<institution>Present Affiliation: Department of Medicine,</institution>
<institution>Brown University School of Medicine,</institution>
</institution-wrap>
Providence, Rhode Island ,02912 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Providence, Rhode Island </wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aronovitz, Mark" sort="Aronovitz, Mark" uniqKey="Aronovitz M" first="Mark" last="Aronovitz">Mark Aronovitz</name>
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<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Molecular Cardiology Research Institute, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Baur, Wendy" sort="Baur, Wendy" uniqKey="Baur W" first="Wendy" last="Baur">Wendy Baur</name>
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<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Molecular Cardiology Research Institute, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wang, Guang Rong" sort="Wang, Guang Rong" uniqKey="Wang G" first="Guang-Rong" last="Wang">Guang-Rong Wang</name>
<affiliation wicri:level="2"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8934 4045</institution-id>
<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Molecular Cardiology Research Institute, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kapur, Navin" sort="Kapur, Navin" uniqKey="Kapur N" first="Navin" last="Kapur">Navin Kapur</name>
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<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Molecular Cardiology Research Institute, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff13"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8934 4045</institution-id>
<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Division of Cardiology, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Karas, Richard" sort="Karas, Richard" uniqKey="Karas R" first="Richard" last="Karas">Richard Karas</name>
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<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Molecular Cardiology Research Institute, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff13"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8934 4045</institution-id>
<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Division of Cardiology, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Blanton, Robert" sort="Blanton, Robert" uniqKey="Blanton R" first="Robert" last="Blanton">Robert Blanton</name>
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<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Molecular Cardiology Research Institute, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff13"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8934 4045</institution-id>
<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Division of Cardiology, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hell, Stefan" sort="Hell, Stefan" uniqKey="Hell S" first="Stefan" last="Hell">Stefan Hell</name>
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<institution-id institution-id-type="GRID">grid.418140.8</institution-id>
<institution>Max Planck Institute for Biophysical Chemistry, Göttingen and German Cancer Research Center (DKFZ),</institution>
</institution-wrap>
Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Waldman, Scott A" sort="Waldman, Scott A" uniqKey="Waldman S" first="Scott A." last="Waldman">Scott A. Waldman</name>
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<institution-id institution-id-type="GRID">grid.265008.9</institution-id>
<institution>Department of Pharmacology and Experimental Therapeutics,</institution>
<institution>Thomas Jefferson University,</institution>
</institution-wrap>
Philadelphia, Pennsylvania 19107 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lin, Jieru E" sort="Lin, Jieru E" uniqKey="Lin J" first="Jieru E." last="Lin">Jieru E. Lin</name>
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<institution-id institution-id-type="GRID">grid.265008.9</institution-id>
<institution>Department of Pharmacology and Experimental Therapeutics,</institution>
<institution>Thomas Jefferson University,</institution>
</institution-wrap>
Philadelphia, Pennsylvania 19107 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Colon Gonzalez, Francheska" sort="Colon Gonzalez, Francheska" uniqKey="Colon Gonzalez F" first="Francheska" last="Colon-Gonzalez">Francheska Colon-Gonzalez</name>
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<institution-id institution-id-type="GRID">grid.265008.9</institution-id>
<institution>Department of Pharmacology and Experimental Therapeutics,</institution>
<institution>Thomas Jefferson University,</institution>
</institution-wrap>
Philadelphia, Pennsylvania 19107 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kim, Gilbert W" sort="Kim, Gilbert W" uniqKey="Kim G" first="Gilbert W." last="Kim">Gilbert W. Kim</name>
<affiliation wicri:level="2"><nlm:aff id="Aff15"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2166 5843</institution-id>
<institution-id institution-id-type="GRID">grid.265008.9</institution-id>
<institution>Department of Pharmacology and Experimental Therapeutics,</institution>
<institution>Thomas Jefferson University,</institution>
</institution-wrap>
Philadelphia, Pennsylvania 19107 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Blomain, Erik S" sort="Blomain, Erik S" uniqKey="Blomain E" first="Erik S." last="Blomain">Erik S. Blomain</name>
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<institution-id institution-id-type="GRID">grid.265008.9</institution-id>
<institution>Department of Pharmacology and Experimental Therapeutics,</institution>
<institution>Thomas Jefferson University,</institution>
</institution-wrap>
Philadelphia, Pennsylvania 19107 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Merlino, Dante" sort="Merlino, Dante" uniqKey="Merlino D" first="Dante" last="Merlino">Dante Merlino</name>
<affiliation wicri:level="2"><nlm:aff id="Aff15"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2166 5843</institution-id>
<institution-id institution-id-type="GRID">grid.265008.9</institution-id>
<institution>Department of Pharmacology and Experimental Therapeutics,</institution>
<institution>Thomas Jefferson University,</institution>
</institution-wrap>
Philadelphia, Pennsylvania 19107 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Snook, Adam" sort="Snook, Adam" uniqKey="Snook A" first="Adam" last="Snook">Adam Snook</name>
<affiliation wicri:level="2"><nlm:aff id="Aff15"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2166 5843</institution-id>
<institution-id institution-id-type="GRID">grid.265008.9</institution-id>
<institution>Department of Pharmacology and Experimental Therapeutics,</institution>
<institution>Thomas Jefferson University,</institution>
</institution-wrap>
Philadelphia, Pennsylvania 19107 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Erdmann, Jeanette" sort="Erdmann, Jeanette" uniqKey="Erdmann J" first="Jeanette" last="Erdmann">Jeanette Erdmann</name>
<affiliation wicri:level="1"><nlm:aff id="Aff16"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0057 2672</institution-id>
<institution-id institution-id-type="GRID">grid.4562.5</institution-id>
<institution>Institut für Kardiogenetik and Universitäres Herzzentrum Lübeck, Universität zu Lübeck, Lübeck, Germany & DZHK e.V. (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck,</institution>
</institution-wrap>
Lübeck, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Lübeck</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wobst, Jana" sort="Wobst, Jana" uniqKey="Wobst J" first="Jana" last="Wobst">Jana Wobst</name>
<affiliation wicri:level="1"><nlm:aff id="Aff17"><institution-wrap><institution-id institution-id-type="ISNI">0000000123222966</institution-id>
<institution-id institution-id-type="GRID">grid.6936.a</institution-id>
<institution>Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen,</institution>
<institution>Technische Universität München,</institution>
</institution-wrap>
Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Munich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kessler, Thorsten" sort="Kessler, Thorsten" uniqKey="Kessler T" first="Thorsten" last="Kessler">Thorsten Kessler</name>
<affiliation wicri:level="1"><nlm:aff id="Aff17"><institution-wrap><institution-id institution-id-type="ISNI">0000000123222966</institution-id>
<institution-id institution-id-type="GRID">grid.6936.a</institution-id>
<institution>Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen,</institution>
<institution>Technische Universität München,</institution>
</institution-wrap>
Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Munich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schunkert, Heribert" sort="Schunkert, Heribert" uniqKey="Schunkert H" first="Heribert" last="Schunkert">Heribert Schunkert</name>
<affiliation wicri:level="1"><nlm:aff id="Aff17"><institution-wrap><institution-id institution-id-type="ISNI">0000000123222966</institution-id>
<institution-id institution-id-type="GRID">grid.6936.a</institution-id>
<institution>Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen,</institution>
<institution>Technische Universität München,</institution>
</institution-wrap>
Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Munich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Walter, Ulrich" sort="Walter, Ulrich" uniqKey="Walter U" first="Ulrich" last="Walter">Ulrich Walter</name>
<affiliation wicri:level="1"><nlm:aff id="Aff18"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1941 7111</institution-id>
<institution-id institution-id-type="GRID">grid.5802.f</institution-id>
<institution>Center for Thrombosis & Hemostasis,</institution>
<institution>Universitätsklinikum der Johannes Gutenberg-Universität Mainz,</institution>
</institution-wrap>
Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Mainz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pagel, Oliver" sort="Pagel, Oliver" uniqKey="Pagel O" first="Oliver" last="Pagel">Oliver Pagel</name>
<affiliation wicri:level="1"><nlm:aff id="Aff19"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0492 9407</institution-id>
<institution-id institution-id-type="GRID">grid.419243.9</institution-id>
<institution>Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V,</institution>
</institution-wrap>
Dortmund, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dortmund</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Walter, Elena" sort="Walter, Elena" uniqKey="Walter E" first="Elena" last="Walter">Elena Walter</name>
<affiliation wicri:level="1"><nlm:aff id="Aff18"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1941 7111</institution-id>
<institution-id institution-id-type="GRID">grid.5802.f</institution-id>
<institution>Center for Thrombosis & Hemostasis,</institution>
<institution>Universitätsklinikum der Johannes Gutenberg-Universität Mainz,</institution>
</institution-wrap>
Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Mainz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gambaryan, Stepan" sort="Gambaryan, Stepan" uniqKey="Gambaryan S" first="Stepan" last="Gambaryan">Stepan Gambaryan</name>
<affiliation wicri:level="1"><nlm:aff id="Aff18"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1941 7111</institution-id>
<institution-id institution-id-type="GRID">grid.5802.f</institution-id>
<institution>Center for Thrombosis & Hemostasis,</institution>
<institution>Universitätsklinikum der Johannes Gutenberg-Universität Mainz,</institution>
</institution-wrap>
Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Mainz</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff20"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0440 2269</institution-id>
<institution-id institution-id-type="GRID">grid.419730.8</institution-id>
<institution>Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences,</institution>
</institution-wrap>
St. Petersburg, Russia</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>St. Petersburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Smolenski, Albert" sort="Smolenski, Albert" uniqKey="Smolenski A" first="Albert" last="Smolenski">Albert Smolenski</name>
<affiliation wicri:level="1"><nlm:aff id="Aff21"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0768 2743</institution-id>
<institution-id institution-id-type="GRID">grid.7886.1</institution-id>
<institution>UCD Conway Institute, UCD School of Medicine and Medical Science,</institution>
<institution>University College Dublin,</institution>
</institution-wrap>
Dublin, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Dublin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jurk, Kerstin" sort="Jurk, Kerstin" uniqKey="Jurk K" first="Kerstin" last="Jurk">Kerstin Jurk</name>
<affiliation wicri:level="1"><nlm:aff id="Aff18"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1941 7111</institution-id>
<institution-id institution-id-type="GRID">grid.5802.f</institution-id>
<institution>Center for Thrombosis & Hemostasis,</institution>
<institution>Universitätsklinikum der Johannes Gutenberg-Universität Mainz,</institution>
</institution-wrap>
Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Mainz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zahedi, Rene" sort="Zahedi, Rene" uniqKey="Zahedi R" first="Rene" last="Zahedi">Rene Zahedi</name>
<affiliation wicri:level="1"><nlm:aff id="Aff19"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0492 9407</institution-id>
<institution-id institution-id-type="GRID">grid.419243.9</institution-id>
<institution>Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V,</institution>
</institution-wrap>
Dortmund, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dortmund</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Klinger, James R" sort="Klinger, James R" uniqKey="Klinger J" first="James R." last="Klinger">James R. Klinger</name>
<affiliation wicri:level="2"><nlm:aff id="Aff22"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9094</institution-id>
<institution-id institution-id-type="GRID">grid.40263.33</institution-id>
<institution>Division of Pulmonary, Sleep and Critical Care Medicine, Rhode Island Hospital,</institution>
<institution>Alpert Medical School of Brown University,</institution>
</institution-wrap>
Providence, RI USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Rhode Island</region>
</placeName>
<wicri:cityArea>Providence</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Benza, Raymond L" sort="Benza, Raymond L" uniqKey="Benza R" first="Raymond L." last="Benza">Raymond L. Benza</name>
<affiliation wicri:level="2"><nlm:aff id="Aff23"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0455 1168</institution-id>
<institution-id institution-id-type="GRID">grid.413621.3</institution-id>
<institution>Cardiovascular Institute, Allegheny General Hospital,</institution>
</institution-wrap>
Pittsburgh, PA USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Pittsburgh</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Corris, Paul A" sort="Corris, Paul A" uniqKey="Corris P" first="Paul A." last="Corris">Paul A. Corris</name>
<affiliation wicri:level="1"><nlm:aff id="Aff24"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0462 7212</institution-id>
<institution-id institution-id-type="GRID">grid.1006.7</institution-id>
<institution>Institute of Cellular Medicine,</institution>
<institution>Newcastle University,</institution>
</institution-wrap>
Newcastle, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Newcastle</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Langleben, David" sort="Langleben, David" uniqKey="Langleben D" first="David" last="Langleben">David Langleben</name>
<affiliation><nlm:aff id="Aff25"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8649</institution-id>
<institution-id institution-id-type="GRID">grid.14709.3b</institution-id>
<institution>Center for Pulmonary Vascular Disease and Lady Davis Institute, Jewish General Hospital,</institution>
<institution>McGill University,</institution>
</institution-wrap>
Montreal, QC Canada</nlm:aff>
<wicri:noCountry code="subfield">QC Canada</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Naeije, Robert" sort="Naeije, Robert" uniqKey="Naeije R" first="Robert" last="Naeije">Robert Naeije</name>
<affiliation wicri:level="1"><nlm:aff id="Aff26"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8571 829X</institution-id>
<institution-id institution-id-type="GRID">grid.412157.4</institution-id>
<institution>Department of Cardiology,</institution>
<institution>Erasme University Hospital,</institution>
</institution-wrap>
Brussels, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Brussels</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Simonneau, Gerald" sort="Simonneau, Gerald" uniqKey="Simonneau G" first="Gérald" last="Simonneau">Gérald Simonneau</name>
<affiliation wicri:level="1"><nlm:aff id="Aff27"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 2558</institution-id>
<institution-id institution-id-type="GRID">grid.5842.b</institution-id>
<institution>Assistance Publique–Hôpitaux de Paris, Service de Pneumologie, Hôpital Bicêtre,</institution>
<institution>Université Paris-Sud, Laboratoire d’Excellence en Recherche sur le Médicament et Innovation Thérapeutique, and INSERM Unité 999,</institution>
</institution-wrap>
Le Kremlin–Bicêtre, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Le Kremlin–Bicêtre</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meier, Christian" sort="Meier, Christian" uniqKey="Meier C" first="Christian" last="Meier">Christian Meier</name>
<affiliation wicri:level="1"><nlm:aff id="Aff28"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Global Clinical Development, Bayer AG,</institution>
</institution-wrap>
Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Colorado, Pablo" sort="Colorado, Pablo" uniqKey="Colorado P" first="Pablo" last="Colorado">Pablo Colorado</name>
<affiliation wicri:level="1"><nlm:aff id="Aff29">Global Clinical Development, Bayer HealthCare Pharmaceuticals, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Global Clinical Development, Bayer HealthCare Pharmaceuticals, Barcelona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chang, Mi Kyung" sort="Chang, Mi Kyung" uniqKey="Chang M" first="Mi Kyung" last="Chang">Mi Kyung Chang</name>
<affiliation wicri:level="1"><nlm:aff id="Aff28"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Global Clinical Development, Bayer AG,</institution>
</institution-wrap>
Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Busse, Dennis" sort="Busse, Dennis" uniqKey="Busse D" first="Dennis" last="Busse">Dennis Busse</name>
<affiliation wicri:level="1"><nlm:aff id="Aff30">Chrestos Concept GmbH & Co, Essen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Chrestos Concept GmbH & Co, Essen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hoeper, Marius M" sort="Hoeper, Marius M" uniqKey="Hoeper M" first="Marius M." last="Hoeper">Marius M. Hoeper</name>
<affiliation wicri:level="1"><nlm:aff id="Aff31"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9529 9877</institution-id>
<institution-id institution-id-type="GRID">grid.10423.34</institution-id>
<institution>Clinic for Respiratory Medicine, Hannover Medical School,</institution>
</institution-wrap>
Hannover, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hannover</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Masferrer, Jaime L" sort="Masferrer, Jaime L" uniqKey="Masferrer J" first="Jaime L." last="Masferrer">Jaime L. Masferrer</name>
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<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
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Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jacobson, Sarah" sort="Jacobson, Sarah" uniqKey="Jacobson S" first="Sarah" last="Jacobson">Sarah Jacobson</name>
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<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Liu, Guang" sort="Liu, Guang" uniqKey="Liu G" first="Guang" last="Liu">Guang Liu</name>
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<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sarno, Renee" sort="Sarno, Renee" uniqKey="Sarno R" first="Renee" last="Sarno">Renee Sarno</name>
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<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bernier, Sylvie" sort="Bernier, Sylvie" uniqKey="Bernier S" first="Sylvie" last="Bernier">Sylvie Bernier</name>
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<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zhang, Ping" sort="Zhang, Ping" uniqKey="Zhang P" first="Ping" last="Zhang">Ping Zhang</name>
</author>
<author><name sortKey="Todd Milne, G" sort="Todd Milne, G" uniqKey="Todd Milne G" first="G." last="Todd Milne">G. Todd Milne</name>
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<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Flores Costa, Roger" sort="Flores Costa, Roger" uniqKey="Flores Costa R" first="Roger" last="Flores-Costa">Roger Flores-Costa</name>
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<institution-id institution-id-type="GRID">grid.410458.c</institution-id>
<institution>Department of Biochemistry and Molecular Genetics,</institution>
<institution>Hospital Clinic-University of Barcelona,</institution>
</institution-wrap>
Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Barcelona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Currie, Mark" sort="Currie, Mark" uniqKey="Currie M" first="Mark" last="Currie">Mark Currie</name>
<affiliation wicri:level="2"><nlm:aff id="Aff32"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hall, Katherine" sort="Hall, Katherine" uniqKey="Hall K" first="Katherine" last="Hall">Katherine Hall</name>
<affiliation wicri:level="2"><nlm:aff id="Aff32"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mohrle, Dorit" sort="Mohrle, Dorit" uniqKey="Mohrle D" first="Dorit" last="Möhrle">Dorit Möhrle</name>
<affiliation wicri:level="1"><nlm:aff id="Aff34"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Elfriede-Aulhorn-Straße 5, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Elfriede-Aulhorn-Straße 5, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Reimann, Katrin" sort="Reimann, Katrin" uniqKey="Reimann K" first="Katrin" last="Reimann">Katrin Reimann</name>
<affiliation wicri:level="1"><nlm:aff id="Aff34"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Elfriede-Aulhorn-Straße 5, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Elfriede-Aulhorn-Straße 5, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wolter, Steffen" sort="Wolter, Steffen" uniqKey="Wolter S" first="Steffen" last="Wolter">Steffen Wolter</name>
<affiliation wicri:level="1"><nlm:aff id="Aff34"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Elfriede-Aulhorn-Straße 5, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Elfriede-Aulhorn-Straße 5, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wolters, Markus" sort="Wolters, Markus" uniqKey="Wolters M" first="Markus" last="Wolters">Markus Wolters</name>
<affiliation wicri:level="1"><nlm:aff id="Aff35"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfaculty Institute of Biochemistry,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Hoppe-Seyler-Straße 4, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hoppe-Seyler-Straße 4, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mergia, Evanthia" sort="Mergia, Evanthia" uniqKey="Mergia E" first="Evanthia" last="Mergia">Evanthia Mergia</name>
<affiliation wicri:level="1"><nlm:aff id="Aff36"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Bochum, Universitätsstr 150,</institution>
</institution-wrap>
44780 Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>44780 Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eichert, Nicole" sort="Eichert, Nicole" uniqKey="Eichert N" first="Nicole" last="Eichert">Nicole Eichert</name>
<affiliation wicri:level="1"><nlm:aff id="Aff34"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Elfriede-Aulhorn-Straße 5, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Elfriede-Aulhorn-Straße 5, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Geisler, Hyun Soon" sort="Geisler, Hyun Soon" uniqKey="Geisler H" first="Hyun-Soon" last="Geisler">Hyun-Soon Geisler</name>
<affiliation wicri:level="1"><nlm:aff id="Aff34"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Elfriede-Aulhorn-Straße 5, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Elfriede-Aulhorn-Straße 5, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ruth, Peter" sort="Ruth, Peter" uniqKey="Ruth P" first="Peter" last="Ruth">Peter Ruth</name>
<affiliation wicri:level="1"><nlm:aff id="Aff37"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Auf der Morgenstelle 8, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Auf der Morgenstelle 8, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Friebe, Andreas" sort="Friebe, Andreas" uniqKey="Friebe A" first="Andreas" last="Friebe">Andreas Friebe</name>
<affiliation wicri:level="1"><nlm:aff id="Aff38"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Department of Physiology,</institution>
<institution>University of Würzburg,</institution>
</institution-wrap>
Röntgenring 9, 97070 Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Röntgenring 9, 97070 Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Feil, Robert" sort="Feil, Robert" uniqKey="Feil R" first="Robert" last="Feil">Robert Feil</name>
<affiliation wicri:level="1"><nlm:aff id="Aff35"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfaculty Institute of Biochemistry,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Hoppe-Seyler-Straße 4, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hoppe-Seyler-Straße 4, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zimmermann, Ulrike" sort="Zimmermann, Ulrike" uniqKey="Zimmermann U" first="Ulrike" last="Zimmermann">Ulrike Zimmermann</name>
<affiliation wicri:level="1"><nlm:aff id="Aff34"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Elfriede-Aulhorn-Straße 5, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Elfriede-Aulhorn-Straße 5, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koesling, Doris" sort="Koesling, Doris" uniqKey="Koesling D" first="Doris" last="Koesling">Doris Koesling</name>
<affiliation wicri:level="1"><nlm:aff id="Aff36"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Bochum, Universitätsstr 150,</institution>
</institution-wrap>
44780 Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>44780 Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Knipper, Marlies" sort="Knipper, Marlies" uniqKey="Knipper M" first="Marlies" last="Knipper">Marlies Knipper</name>
<affiliation wicri:level="1"><nlm:aff id="Aff34"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Elfriede-Aulhorn-Straße 5, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Elfriede-Aulhorn-Straße 5, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ruttiger, Lukas" sort="Ruttiger, Lukas" uniqKey="Ruttiger L" first="Lukas" last="Rüttiger">Lukas Rüttiger</name>
<affiliation wicri:level="1"><nlm:aff id="Aff34"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Elfriede-Aulhorn-Straße 5, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Elfriede-Aulhorn-Straße 5, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tanaka, Yasutake" sort="Tanaka, Yasutake" uniqKey="Tanaka Y" first="Yasutake" last="Tanaka">Yasutake Tanaka</name>
<affiliation wicri:level="1"><nlm:aff id="Aff39"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Okamoto, Atsuko" sort="Okamoto, Atsuko" uniqKey="Okamoto A" first="Atsuko" last="Okamoto">Atsuko Okamoto</name>
<affiliation wicri:level="1"><nlm:aff id="Aff39"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nojiri, Takashi" sort="Nojiri, Takashi" uniqKey="Nojiri T" first="Takashi" last="Nojiri">Takashi Nojiri</name>
<affiliation wicri:level="1"><nlm:aff id="Aff39"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff40"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0373 3971</institution-id>
<institution-id institution-id-type="GRID">grid.136593.b</institution-id>
<institution>Department of General Thoracic Surgery,</institution>
<institution>Osaka University Graduate School of Medicine,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kumazoe, Motofumi" sort="Kumazoe, Motofumi" uniqKey="Kumazoe M" first="Motofumi" last="Kumazoe">Motofumi Kumazoe</name>
<affiliation wicri:level="1"><nlm:aff id="Aff39"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tokudome, Takeshi" sort="Tokudome, Takeshi" uniqKey="Tokudome T" first="Takeshi" last="Tokudome">Takeshi Tokudome</name>
<affiliation wicri:level="1"><nlm:aff id="Aff39"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Miura, Koichi" sort="Miura, Koichi" uniqKey="Miura K" first="Koichi" last="Miura">Koichi Miura</name>
<affiliation wicri:level="1"><nlm:aff id="Aff39"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hino, Jun" sort="Hino, Jun" uniqKey="Hino J" first="Jun" last="Hino">Jun Hino</name>
<affiliation wicri:level="1"><nlm:aff id="Aff39"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hosoda, Hiroshi" sort="Hosoda, Hiroshi" uniqKey="Hosoda H" first="Hiroshi" last="Hosoda">Hiroshi Hosoda</name>
<affiliation wicri:level="1"><nlm:aff id="Aff41"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Miyazato, Mikiya" sort="Miyazato, Mikiya" uniqKey="Miyazato M" first="Mikiya" last="Miyazato">Mikiya Miyazato</name>
<affiliation wicri:level="1"><nlm:aff id="Aff39"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kangawa, Kenji" sort="Kangawa, Kenji" uniqKey="Kangawa K" first="Kenji" last="Kangawa">Kenji Kangawa</name>
<affiliation wicri:level="1"><nlm:aff id="Aff39"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kapil, Vikas" sort="Kapil, Vikas" uniqKey="Kapil V" first="Vikas" last="Kapil">Vikas Kapil</name>
<affiliation wicri:level="1"><nlm:aff id="Aff42"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, Barts & The London School of Medicine, QMUL,</institution>
</institution-wrap>
London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ahluwalia, Amrita" sort="Ahluwalia, Amrita" uniqKey="Ahluwalia A" first="Amrita" last="Ahluwalia">Amrita Ahluwalia</name>
<affiliation wicri:level="1"><nlm:aff id="Aff42"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, Barts & The London School of Medicine, QMUL,</institution>
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London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Paolocci, Nazareno" sort="Paolocci, Nazareno" uniqKey="Paolocci N" first="Nazareno" last="Paolocci">Nazareno Paolocci</name>
<affiliation><nlm:aff id="Aff43"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 9311</institution-id>
<institution-id institution-id-type="GRID">grid.21107.35</institution-id>
<institution>Division of Cardiology, Department of Medicine,</institution>
<institution>Johns Hopkins Medical Institutions,</institution>
</institution-wrap>
Baltimore, Maryland USA</nlm:aff>
<wicri:noCountry code="subfield">Maryland USA</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff44"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1757 3630</institution-id>
<institution-id institution-id-type="GRID">grid.9027.c</institution-id>
<institution>Department of Experimental Medicine,</institution>
<institution>University of Perugia,</institution>
</institution-wrap>
06123 Perugia, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>06123 Perugia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eaton, Philip" sort="Eaton, Philip" uniqKey="Eaton P" first="Philip" last="Eaton">Philip Eaton</name>
<affiliation wicri:level="1"><nlm:aff id="Aff45"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>King’s College London, Cardiovascular Division, The Rayne Institute,</institution>
</institution-wrap>
St Thomas’ Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>St Thomas’ Hospital, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Campbell, James C" sort="Campbell, James C" uniqKey="Campbell J" first="James C." last="Campbell">James C. Campbell</name>
<affiliation wicri:level="2"><nlm:aff id="Aff46"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Structural and Computational Biology and Molecular Biophysics Program,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, TX USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Houston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff47"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, TX USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Henning, Philipp" sort="Henning, Philipp" uniqKey="Henning P" first="Philipp" last="Henning">Philipp Henning</name>
<affiliation><nlm:aff id="Aff48"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1089 1036</institution-id>
<institution-id institution-id-type="GRID">grid.5155.4</institution-id>
<institution>Department of Biochemistry,</institution>
<institution>University of Kassel,</institution>
</institution-wrap>
Kassel, Hesse Germany</nlm:aff>
<wicri:noCountry code="subfield">Hesse Germany</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Franz, Eugen" sort="Franz, Eugen" uniqKey="Franz E" first="Eugen" last="Franz">Eugen Franz</name>
<affiliation><nlm:aff id="Aff48"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1089 1036</institution-id>
<institution-id institution-id-type="GRID">grid.5155.4</institution-id>
<institution>Department of Biochemistry,</institution>
<institution>University of Kassel,</institution>
</institution-wrap>
Kassel, Hesse Germany</nlm:aff>
<wicri:noCountry code="subfield">Hesse Germany</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sankaran, Banumathi" sort="Sankaran, Banumathi" uniqKey="Sankaran B" first="Banumathi" last="Sankaran">Banumathi Sankaran</name>
<affiliation wicri:level="2"><nlm:aff id="Aff49"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2231 4551</institution-id>
<institution-id institution-id-type="GRID">grid.184769.5</institution-id>
<institution>Berkeley Center for Structural Biology, Lawrence Berkeley National Laboratory,</institution>
</institution-wrap>
Berkeley, CA USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Berkeley</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Herberg, Friedrich W" sort="Herberg, Friedrich W" uniqKey="Herberg F" first="Friedrich W." last="Herberg">Friedrich W. Herberg</name>
<affiliation wicri:level="2"><nlm:aff id="Aff49"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2231 4551</institution-id>
<institution-id institution-id-type="GRID">grid.184769.5</institution-id>
<institution>Berkeley Center for Structural Biology, Lawrence Berkeley National Laboratory,</institution>
</institution-wrap>
Berkeley, CA USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Berkeley</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kim, Choel" sort="Kim, Choel" uniqKey="Kim C" first="Choel" last="Kim">Choel Kim</name>
<affiliation wicri:level="2"><nlm:aff id="Aff46"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Structural and Computational Biology and Molecular Biophysics Program,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, TX USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Houston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff47"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, TX USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Houston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff50"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Verna and Marrs McLean Department of Biochemistry and Molecular Biology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, TX USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wittwer, M" sort="Wittwer, M" uniqKey="Wittwer M" first="M." last="Wittwer">M. Wittwer</name>
<affiliation wicri:level="1"><nlm:aff id="Aff51"><institution-wrap><institution-id institution-id-type="ISNI">0000000123222966</institution-id>
<institution-id institution-id-type="GRID">grid.6936.a</institution-id>
<institution>Technische Universität München, Department of Chemistry, Biomolecular NMR Spectroscopy,</institution>
</institution-wrap>
Garching, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Garching</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Luo, Q" sort="Luo, Q" uniqKey="Luo Q" first="Q." last="Luo">Q. Luo</name>
<affiliation wicri:level="1"><nlm:aff id="Aff52"><institution-wrap><institution-id institution-id-type="ISNI">0000000123222966</institution-id>
<institution-id institution-id-type="GRID">grid.6936.a</institution-id>
<institution>Technische Universität München, Department of Chemistry, Computational Biocatalysis,</institution>
</institution-wrap>
Garching, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Garching</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kaila, V" sort="Kaila, V" uniqKey="Kaila V" first="V." last="Kaila">V. Kaila</name>
<affiliation wicri:level="1"><nlm:aff id="Aff52"><institution-wrap><institution-id institution-id-type="ISNI">0000000123222966</institution-id>
<institution-id institution-id-type="GRID">grid.6936.a</institution-id>
<institution>Technische Universität München, Department of Chemistry, Computational Biocatalysis,</institution>
</institution-wrap>
Garching, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Garching</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dames, S A" sort="Dames, S A" uniqKey="Dames S" first="S. A." last="Dames">S. A. Dames</name>
<affiliation wicri:level="1"><nlm:aff id="Aff51"><institution-wrap><institution-id institution-id-type="ISNI">0000000123222966</institution-id>
<institution-id institution-id-type="GRID">grid.6936.a</institution-id>
<institution>Technische Universität München, Department of Chemistry, Biomolecular NMR Spectroscopy,</institution>
</institution-wrap>
Garching, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Garching</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff53"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0483 2525</institution-id>
<institution-id institution-id-type="GRID">grid.4567.0</institution-id>
<institution>Institute of Structural Biology, Helmholtz Zentrum München,</institution>
</institution-wrap>
Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Neuherberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tobin, Andrew" sort="Tobin, Andrew" uniqKey="Tobin A" first="Andrew" last="Tobin">Andrew Tobin</name>
<affiliation wicri:level="1"><nlm:aff id="Aff54"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2193 314X</institution-id>
<institution-id institution-id-type="GRID">grid.8756.c</institution-id>
<institution>Institute of Molecular Cell and Systems Biology,</institution>
<institution>University of Glasgow,</institution>
</institution-wrap>
Glasgow, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Glasgow</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alam, Mahmood" sort="Alam, Mahmood" uniqKey="Alam M" first="Mahmood" last="Alam">Mahmood Alam</name>
<affiliation wicri:level="1"><nlm:aff id="Aff54"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2193 314X</institution-id>
<institution-id institution-id-type="GRID">grid.8756.c</institution-id>
<institution>Institute of Molecular Cell and Systems Biology,</institution>
<institution>University of Glasgow,</institution>
</institution-wrap>
Glasgow, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Glasgow</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rudyk, Olena" sort="Rudyk, Olena" uniqKey="Rudyk O" first="Olena" last="Rudyk">Olena Rudyk</name>
<affiliation><nlm:aff id="Aff55"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>BHF Centre of Research Excellence, King’s College London,</institution>
</institution-wrap>
London, SE1 7EH UK</nlm:aff>
<wicri:noCountry code="subfield">SE1 7EH UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Krasemann, Susanne" sort="Krasemann, Susanne" uniqKey="Krasemann S" first="Susanne" last="Krasemann">Susanne Krasemann</name>
<affiliation wicri:level="1"><nlm:aff id="Aff56"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Core Facility for Mouse Pathology,</institution>
<institution>University Medical Centre Hamburg-Eppendorf,</institution>
</institution-wrap>
20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>20246 Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hartmann, Kristin" sort="Hartmann, Kristin" uniqKey="Hartmann K" first="Kristin" last="Hartmann">Kristin Hartmann</name>
<affiliation wicri:level="1"><nlm:aff id="Aff56"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Core Facility for Mouse Pathology,</institution>
<institution>University Medical Centre Hamburg-Eppendorf,</institution>
</institution-wrap>
20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>20246 Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Prysyazhna, Oleksandra" sort="Prysyazhna, Oleksandra" uniqKey="Prysyazhna O" first="Oleksandra" last="Prysyazhna">Oleksandra Prysyazhna</name>
<affiliation><nlm:aff id="Aff55"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>BHF Centre of Research Excellence, King’s College London,</institution>
</institution-wrap>
London, SE1 7EH UK</nlm:aff>
<wicri:noCountry code="subfield">SE1 7EH UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Zhang, Min" sort="Zhang, Min" uniqKey="Zhang M" first="Min" last="Zhang">Min Zhang</name>
<affiliation><nlm:aff id="Aff55"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>BHF Centre of Research Excellence, King’s College London,</institution>
</institution-wrap>
London, SE1 7EH UK</nlm:aff>
<wicri:noCountry code="subfield">SE1 7EH UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Zhao, Lan" sort="Zhao, Lan" uniqKey="Zhao L" first="Lan" last="Zhao">Lan Zhao</name>
<affiliation><nlm:aff id="Aff57"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2113 8111</institution-id>
<institution-id institution-id-type="GRID">grid.7445.2</institution-id>
<institution>Faculty of Medicine, Department of Medicine, Imperial College London,</institution>
</institution-wrap>
London, SW7 2AZ UK</nlm:aff>
<wicri:noCountry code="subfield">SW7 2AZ UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Weiss, Astrid" sort="Weiss, Astrid" uniqKey="Weiss A" first="Astrid" last="Weiss">Astrid Weiss</name>
<affiliation wicri:level="1"><nlm:aff id="Aff58"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2165 8627</institution-id>
<institution-id institution-id-type="GRID">grid.8664.c</institution-id>
<institution>Excellence Cluster Cardio-Pulmonary System,</institution>
<institution>Universities of Giessen and Marburg Lung Centre Member of the German Lung Canter Justus-Liebig-University Giessen,</institution>
</institution-wrap>
Giessen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Giessen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schermuly, Ralph" sort="Schermuly, Ralph" uniqKey="Schermuly R" first="Ralph" last="Schermuly">Ralph Schermuly</name>
<affiliation wicri:level="1"><nlm:aff id="Aff58"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2165 8627</institution-id>
<institution-id institution-id-type="GRID">grid.8664.c</institution-id>
<institution>Excellence Cluster Cardio-Pulmonary System,</institution>
<institution>Universities of Giessen and Marburg Lung Centre Member of the German Lung Canter Justus-Liebig-University Giessen,</institution>
</institution-wrap>
Giessen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Giessen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eaton, Philip" sort="Eaton, Philip" uniqKey="Eaton P" first="Philip" last="Eaton">Philip Eaton</name>
<affiliation><nlm:aff id="Aff55"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>BHF Centre of Research Excellence, King’s College London,</institution>
</institution-wrap>
London, SE1 7EH UK</nlm:aff>
<wicri:noCountry code="subfield">SE1 7EH UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Moyes, Amie J" sort="Moyes, Amie J" uniqKey="Moyes A" first="Amie J." last="Moyes">Amie J. Moyes</name>
<affiliation wicri:level="1"><nlm:aff id="Aff59"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, Barts & The London School of Medicine, QMUL,</institution>
</institution-wrap>
London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chu, Sandy M" sort="Chu, Sandy M" uniqKey="Chu S" first="Sandy M." last="Chu">Sandy M. Chu</name>
<affiliation wicri:level="1"><nlm:aff id="Aff59"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, Barts & The London School of Medicine, QMUL,</institution>
</institution-wrap>
London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Baliga, Reshma S" sort="Baliga, Reshma S" uniqKey="Baliga R" first="Reshma S." last="Baliga">Reshma S. Baliga</name>
<affiliation wicri:level="1"><nlm:aff id="Aff59"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, Barts & The London School of Medicine, QMUL,</institution>
</institution-wrap>
London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hobbs, Adrian J" sort="Hobbs, Adrian J" uniqKey="Hobbs A" first="Adrian J." last="Hobbs">Adrian J. Hobbs</name>
<affiliation wicri:level="1"><nlm:aff id="Aff59"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, Barts & The London School of Medicine, QMUL,</institution>
</institution-wrap>
London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Michalakis, Stylianos" sort="Michalakis, Stylianos" uniqKey="Michalakis S" first="Stylianos" last="Michalakis">Stylianos Michalakis</name>
<affiliation wicri:level="1"><nlm:aff id="Aff60"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 973X</institution-id>
<institution-id institution-id-type="GRID">grid.5252.0</institution-id>
<institution>Center for Integrated Protein Science Munich CiPSM at the Department of Pharmacy – Center for Drug Research,</institution>
<institution>Ludwig-Maximilians-Universität München,</institution>
</institution-wrap>
Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Munich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Muhlfriedel, Regine" sort="Muhlfriedel, Regine" uniqKey="Muhlfriedel R" first="Regine" last="Mühlfriedel">Regine Mühlfriedel</name>
<affiliation wicri:level="1"><nlm:aff id="Aff61">Institute for Ophthalmic Research, Centre for OphthalmologyUniversity of Tübingen, Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Ophthalmic Research, Centre for OphthalmologyUniversity of Tübingen, Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schon, Christian" sort="Schon, Christian" uniqKey="Schon C" first="Christian" last="Schön">Christian Schön</name>
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<institution-id institution-id-type="GRID">grid.5252.0</institution-id>
<institution>Center for Integrated Protein Science Munich CiPSM at the Department of Pharmacy – Center for Drug Research,</institution>
<institution>Ludwig-Maximilians-Universität München,</institution>
</institution-wrap>
Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Munich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fischer, Dominik M" sort="Fischer, Dominik M" uniqKey="Fischer D" first="Dominik M." last="Fischer">Dominik M. Fischer</name>
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<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>University Eye Hospital, Centre for Ophthalmology Tübingen,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wilhelm, Barbara" sort="Wilhelm, Barbara" uniqKey="Wilhelm B" first="Barbara" last="Wilhelm">Barbara Wilhelm</name>
<affiliation wicri:level="1"><nlm:aff id="Aff63"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>STZ eyetrial at the Centre for Ophthalmology,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zobor, Ditta" sort="Zobor, Ditta" uniqKey="Zobor D" first="Ditta" last="Zobor">Ditta Zobor</name>
<affiliation wicri:level="1"><nlm:aff id="Aff62"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>University Eye Hospital, Centre for Ophthalmology Tübingen,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kohl, Susanne" sort="Kohl, Susanne" uniqKey="Kohl S" first="Susanne" last="Kohl">Susanne Kohl</name>
<affiliation wicri:level="1"><nlm:aff id="Aff61">Institute for Ophthalmic Research, Centre for OphthalmologyUniversity of Tübingen, Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Ophthalmic Research, Centre for OphthalmologyUniversity of Tübingen, Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peters, Tobias" sort="Peters, Tobias" uniqKey="Peters T" first="Tobias" last="Peters">Tobias Peters</name>
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<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>STZ eyetrial at the Centre for Ophthalmology,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zrenner, Eberhart" sort="Zrenner, Eberhart" uniqKey="Zrenner E" first="Eberhart" last="Zrenner">Eberhart Zrenner</name>
<affiliation wicri:level="1"><nlm:aff id="Aff61">Institute for Ophthalmic Research, Centre for OphthalmologyUniversity of Tübingen, Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Ophthalmic Research, Centre for OphthalmologyUniversity of Tübingen, Tübingen</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff62"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>University Eye Hospital, Centre for Ophthalmology Tübingen,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bartz Schmidt, Karl Ulrich" sort="Bartz Schmidt, Karl Ulrich" uniqKey="Bartz Schmidt K" first="Karl Ulrich" last="Bartz-Schmidt">Karl Ulrich Bartz-Schmidt</name>
<affiliation wicri:level="1"><nlm:aff id="Aff62"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>University Eye Hospital, Centre for Ophthalmology Tübingen,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ueffing, Marius" sort="Ueffing, Marius" uniqKey="Ueffing M" first="Marius" last="Ueffing">Marius Ueffing</name>
<affiliation wicri:level="1"><nlm:aff id="Aff62"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>University Eye Hospital, Centre for Ophthalmology Tübingen,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wissinger, Bernd" sort="Wissinger, Bernd" uniqKey="Wissinger B" first="Bernd" last="Wissinger">Bernd Wissinger</name>
<affiliation wicri:level="1"><nlm:aff id="Aff62"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>University Eye Hospital, Centre for Ophthalmology Tübingen,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Seeliger, Mathias" sort="Seeliger, Mathias" uniqKey="Seeliger M" first="Mathias" last="Seeliger">Mathias Seeliger</name>
<affiliation wicri:level="1"><nlm:aff id="Aff62"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>University Eye Hospital, Centre for Ophthalmology Tübingen,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Biel, Martin" sort="Biel, Martin" uniqKey="Biel M" first="Martin" last="Biel">Martin Biel</name>
<affiliation wicri:level="1"><nlm:aff id="Aff60"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 973X</institution-id>
<institution-id institution-id-type="GRID">grid.5252.0</institution-id>
<institution>Center for Integrated Protein Science Munich CiPSM at the Department of Pharmacy – Center for Drug Research,</institution>
<institution>Ludwig-Maximilians-Universität München,</institution>
</institution-wrap>
Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Munich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ranek, Mark J" sort="Ranek, Mark J" uniqKey="Ranek M" first="Mark J." last="Ranek">Mark J. Ranek</name>
<affiliation wicri:level="2"><nlm:aff id="Aff64"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 9311</institution-id>
<institution-id institution-id-type="GRID">grid.21107.35</institution-id>
<institution>Division of Cardiology,</institution>
<institution>Johns Hopkins Medical Institutions,</institution>
</institution-wrap>
Baltimore, MD 21205 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kokkonen, Kristen M" sort="Kokkonen, Kristen M" uniqKey="Kokkonen K" first="Kristen M." last="Kokkonen">Kristen M. Kokkonen</name>
<affiliation wicri:level="2"><nlm:aff id="Aff64"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 9311</institution-id>
<institution-id institution-id-type="GRID">grid.21107.35</institution-id>
<institution>Division of Cardiology,</institution>
<institution>Johns Hopkins Medical Institutions,</institution>
</institution-wrap>
Baltimore, MD 21205 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lee, Dong I" sort="Lee, Dong I" uniqKey="Lee D" first="Dong I." last="Lee">Dong I. Lee</name>
<affiliation wicri:level="2"><nlm:aff id="Aff64"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 9311</institution-id>
<institution-id institution-id-type="GRID">grid.21107.35</institution-id>
<institution>Division of Cardiology,</institution>
<institution>Johns Hopkins Medical Institutions,</institution>
</institution-wrap>
Baltimore, MD 21205 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Holewinski, Ronald J" sort="Holewinski, Ronald J" uniqKey="Holewinski R" first="Ronald J." last="Holewinski">Ronald J. Holewinski</name>
<affiliation wicri:level="2"><nlm:aff id="Aff65">Heart Institute and Advanced Clinical Biosystems Research Institute, Cedar Sinai Medical Center, 8700 Beverly Blvd, AHSP A9229, Los Angeles, California 90048 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Heart Institute and Advanced Clinical Biosystems Research Institute, Cedar Sinai Medical Center, 8700 Beverly Blvd, AHSP A9229, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Agrawal, Vineet" sort="Agrawal, Vineet" uniqKey="Agrawal V" first="Vineet" last="Agrawal">Vineet Agrawal</name>
<affiliation wicri:level="2"><nlm:aff id="Aff64"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 9311</institution-id>
<institution-id institution-id-type="GRID">grid.21107.35</institution-id>
<institution>Division of Cardiology,</institution>
<institution>Johns Hopkins Medical Institutions,</institution>
</institution-wrap>
Baltimore, MD 21205 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Virus, Cornelia" sort="Virus, Cornelia" uniqKey="Virus C" first="Cornelia" last="Virus">Cornelia Virus</name>
<affiliation wicri:level="2"><nlm:aff id="Aff66"><institution-wrap><institution-id institution-id-type="ISNI">0000000122483208</institution-id>
<institution-id institution-id-type="GRID">grid.10698.36</institution-id>
<institution>McAllister Heart Institute, Division of Cardiology, UNC,</institution>
</institution-wrap>
Chapel Hill, NC USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Chapel Hill</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Stevens, Donte A" sort="Stevens, Donte A" uniqKey="Stevens D" first="Donté A." last="Stevens">Donté A. Stevens</name>
<affiliation wicri:level="2"><nlm:aff id="Aff66"><institution-wrap><institution-id institution-id-type="ISNI">0000000122483208</institution-id>
<institution-id institution-id-type="GRID">grid.10698.36</institution-id>
<institution>McAllister Heart Institute, Division of Cardiology, UNC,</institution>
</institution-wrap>
Chapel Hill, NC USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Chapel Hill</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sasaki, Masayuki" sort="Sasaki, Masayuki" uniqKey="Sasaki M" first="Masayuki" last="Sasaki">Masayuki Sasaki</name>
<affiliation wicri:level="2"><nlm:aff id="Aff64"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 9311</institution-id>
<institution-id institution-id-type="GRID">grid.21107.35</institution-id>
<institution>Division of Cardiology,</institution>
<institution>Johns Hopkins Medical Institutions,</institution>
</institution-wrap>
Baltimore, MD 21205 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zhang, Huaqun" sort="Zhang, Huaqun" uniqKey="Zhang H" first="Huaqun" last="Zhang">Huaqun Zhang</name>
<affiliation wicri:level="2"><nlm:aff id="Aff67"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2195 6763</institution-id>
<institution-id institution-id-type="GRID">grid.259956.4</institution-id>
<institution>Department of Chemistry and Biochemistry,</institution>
<institution>Miami University,</institution>
</institution-wrap>
Oxford, OH 45056 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Oxford</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mannion, Mathew M" sort="Mannion, Mathew M" uniqKey="Mannion M" first="Mathew M." last="Mannion">Mathew M. Mannion</name>
<affiliation wicri:level="2"><nlm:aff id="Aff67"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2195 6763</institution-id>
<institution-id institution-id-type="GRID">grid.259956.4</institution-id>
<institution>Department of Chemistry and Biochemistry,</institution>
<institution>Miami University,</institution>
</institution-wrap>
Oxford, OH 45056 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Oxford</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rainer, Peter P" sort="Rainer, Peter P" uniqKey="Rainer P" first="Peter P." last="Rainer">Peter P. Rainer</name>
<affiliation wicri:level="2"><nlm:aff id="Aff64"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 9311</institution-id>
<institution-id institution-id-type="GRID">grid.21107.35</institution-id>
<institution>Division of Cardiology,</institution>
<institution>Johns Hopkins Medical Institutions,</institution>
</institution-wrap>
Baltimore, MD 21205 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Page, Richard C" sort="Page, Richard C" uniqKey="Page R" first="Richard C." last="Page">Richard C. Page</name>
<affiliation wicri:level="2"><nlm:aff id="Aff67"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2195 6763</institution-id>
<institution-id institution-id-type="GRID">grid.259956.4</institution-id>
<institution>Department of Chemistry and Biochemistry,</institution>
<institution>Miami University,</institution>
</institution-wrap>
Oxford, OH 45056 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Oxford</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Schisler, Jonathan C" sort="Schisler, Jonathan C" uniqKey="Schisler J" first="Jonathan C." last="Schisler">Jonathan C. Schisler</name>
<affiliation wicri:level="2"><nlm:aff id="Aff66"><institution-wrap><institution-id institution-id-type="ISNI">0000000122483208</institution-id>
<institution-id institution-id-type="GRID">grid.10698.36</institution-id>
<institution>McAllister Heart Institute, Division of Cardiology, UNC,</institution>
</institution-wrap>
Chapel Hill, NC USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Chapel Hill</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Van Eyk, Jennifer E" sort="Van Eyk, Jennifer E" uniqKey="Van Eyk J" first="Jennifer E." last="Van Eyk">Jennifer E. Van Eyk</name>
<affiliation wicri:level="2"><nlm:aff id="Aff65">Heart Institute and Advanced Clinical Biosystems Research Institute, Cedar Sinai Medical Center, 8700 Beverly Blvd, AHSP A9229, Los Angeles, California 90048 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Heart Institute and Advanced Clinical Biosystems Research Institute, Cedar Sinai Medical Center, 8700 Beverly Blvd, AHSP A9229, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Willis, Monte S" sort="Willis, Monte S" uniqKey="Willis M" first="Monte S." last="Willis">Monte S. Willis</name>
<affiliation wicri:level="2"><nlm:aff id="Aff66"><institution-wrap><institution-id institution-id-type="ISNI">0000000122483208</institution-id>
<institution-id institution-id-type="GRID">grid.10698.36</institution-id>
<institution>McAllister Heart Institute, Division of Cardiology, UNC,</institution>
</institution-wrap>
Chapel Hill, NC USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Chapel Hill</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kass, David A" sort="Kass, David A" uniqKey="Kass D" first="David A." last="Kass">David A. Kass</name>
<affiliation wicri:level="2"><nlm:aff id="Aff64"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 9311</institution-id>
<institution-id institution-id-type="GRID">grid.21107.35</institution-id>
<institution>Division of Cardiology,</institution>
<institution>Johns Hopkins Medical Institutions,</institution>
</institution-wrap>
Baltimore, MD 21205 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zaccolo, Manuela" sort="Zaccolo, Manuela" uniqKey="Zaccolo M" first="Manuela" last="Zaccolo">Manuela Zaccolo</name>
<affiliation wicri:level="1"><nlm:aff id="Aff68">Department of Pyhisology, Anatomy and GeneticsUniversity of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Pyhisology, Anatomy and GeneticsUniversity of Oxford, Oxford</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Russwurm, Michael" sort="Russwurm, Michael" uniqKey="Russwurm M" first="Michael" last="Russwurm">Michael Russwurm</name>
<affiliation wicri:level="1"><nlm:aff id="Aff69"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Institute for Pharmacology and Toxicology, Medical Faculty,</institution>
<institution>Ruhr-University Bochum,</institution>
</institution-wrap>
44780 Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>44780 Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Giesen, Jan" sort="Giesen, Jan" uniqKey="Giesen J" first="Jan" last="Giesen">Jan Giesen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff69"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Institute for Pharmacology and Toxicology, Medical Faculty,</institution>
<institution>Ruhr-University Bochum,</institution>
</institution-wrap>
44780 Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>44780 Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Russwurm, Corina" sort="Russwurm, Corina" uniqKey="Russwurm C" first="Corina" last="Russwurm">Corina Russwurm</name>
<affiliation wicri:level="1"><nlm:aff id="Aff69"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Institute for Pharmacology and Toxicology, Medical Faculty,</institution>
<institution>Ruhr-University Bochum,</institution>
</institution-wrap>
44780 Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>44780 Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fuchtbauer, Ernst Martin" sort="Fuchtbauer, Ernst Martin" uniqKey="Fuchtbauer E" first="Ernst-Martin" last="Füchtbauer">Ernst-Martin Füchtbauer</name>
<affiliation wicri:level="1"><nlm:aff id="Aff70"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1956 2722</institution-id>
<institution-id institution-id-type="GRID">grid.7048.b</institution-id>
<institution>Department of Molecular Biology and Genetics - Molecular Cell and Developmental Biology,</institution>
<institution>Aarhus University,</institution>
</institution-wrap>
C.F. Møllers Allé 3, 8000 Aarhus C, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>C.F. Møllers Allé 3, 8000 Aarhus C</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koesling, Doris" sort="Koesling, Doris" uniqKey="Koesling D" first="Doris" last="Koesling">Doris Koesling</name>
<affiliation wicri:level="1"><nlm:aff id="Aff69"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Institute for Pharmacology and Toxicology, Medical Faculty,</institution>
<institution>Ruhr-University Bochum,</institution>
</institution-wrap>
44780 Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>44780 Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bork, Nadja I" sort="Bork, Nadja I" uniqKey="Bork N" first="Nadja I." last="Bork">Nadja I. Bork</name>
<affiliation wicri:level="1"><nlm:aff id="Aff71"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Institute of Experimental Cardiovascular Research, Center for Experimental Medicine,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nikolaev, Viacheslav O" sort="Nikolaev, Viacheslav O" uniqKey="Nikolaev V" first="Viacheslav O." last="Nikolaev">Viacheslav O. Nikolaev</name>
<affiliation wicri:level="1"><nlm:aff id="Aff71"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Institute of Experimental Cardiovascular Research, Center for Experimental Medicine,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Agull, Luis" sort="Agull, Luis" uniqKey="Agull L" first="Luis" last="Agull">Luis Agull</name>
<affiliation><nlm:aff id="Aff72"><institution-wrap><institution-id institution-id-type="GRID">grid.440820.a</institution-id>
<institution>Computational Biochemistry and Biophysics Laboratory (CBBL), U_ScienceTech (UST),</institution>
<institution>University of Vic - Central University of Catalonia (UVIC-UCC),</institution>
</institution-wrap>
Vic, Barcelona Spain</nlm:aff>
<wicri:noCountry code="subfield">Barcelona Spain</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Floor, Martin" sort="Floor, Martin" uniqKey="Floor M" first="Martin" last="Floor">Martin Floor</name>
<affiliation><nlm:aff id="Aff72"><institution-wrap><institution-id institution-id-type="GRID">grid.440820.a</institution-id>
<institution>Computational Biochemistry and Biophysics Laboratory (CBBL), U_ScienceTech (UST),</institution>
<institution>University of Vic - Central University of Catalonia (UVIC-UCC),</institution>
</institution-wrap>
Vic, Barcelona Spain</nlm:aff>
<wicri:noCountry code="subfield">Barcelona Spain</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Villa Freixa, Jordi" sort="Villa Freixa, Jordi" uniqKey="Villa Freixa J" first="Jordi" last="Villà-Freixa">Jordi Villà-Freixa</name>
<affiliation><nlm:aff id="Aff72"><institution-wrap><institution-id institution-id-type="GRID">grid.440820.a</institution-id>
<institution>Computational Biochemistry and Biophysics Laboratory (CBBL), U_ScienceTech (UST),</institution>
<institution>University of Vic - Central University of Catalonia (UVIC-UCC),</institution>
</institution-wrap>
Vic, Barcelona Spain</nlm:aff>
<wicri:noCountry code="subfield">Barcelona Spain</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Manfra, Ornella" sort="Manfra, Ornella" uniqKey="Manfra O" first="Ornella" last="Manfra">Ornella Manfra</name>
<affiliation wicri:level="1"><nlm:aff id="Aff73"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff74"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Calamera, Gaia" sort="Calamera, Gaia" uniqKey="Calamera G" first="Gaia" last="Calamera">Gaia Calamera</name>
<affiliation wicri:level="1"><nlm:aff id="Aff73"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff74"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Surdo, Nicoletta C" sort="Surdo, Nicoletta C" uniqKey="Surdo N" first="Nicoletta C." last="Surdo">Nicoletta C. Surdo</name>
<affiliation wicri:level="1"><nlm:aff id="Aff75"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Department of Physiology, Anatomy and Genetics,</institution>
<institution>Oxford University,</institution>
</institution-wrap>
Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meier, Silja" sort="Meier, Silja" uniqKey="Meier S" first="Silja" last="Meier">Silja Meier</name>
<affiliation wicri:level="1"><nlm:aff id="Aff73"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff74"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Froese, Alexander" sort="Froese, Alexander" uniqKey="Froese A" first="Alexander" last="Froese">Alexander Froese</name>
<affiliation wicri:level="1"><nlm:aff id="Aff76"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>German Center for Cardiovascular Research,</institution>
<institution>University Medical Center Hamburg-Eppendorf and Institute of Experimental Cardiovascular Research,</institution>
</institution-wrap>
Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nikolaev, Viacheslav O" sort="Nikolaev, Viacheslav O" uniqKey="Nikolaev V" first="Viacheslav O." last="Nikolaev">Viacheslav O. Nikolaev</name>
<affiliation wicri:level="1"><nlm:aff id="Aff76"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>German Center for Cardiovascular Research,</institution>
<institution>University Medical Center Hamburg-Eppendorf and Institute of Experimental Cardiovascular Research,</institution>
</institution-wrap>
Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zaccolo, Manuela" sort="Zaccolo, Manuela" uniqKey="Zaccolo M" first="Manuela" last="Zaccolo">Manuela Zaccolo</name>
<affiliation wicri:level="1"><nlm:aff id="Aff75"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Department of Physiology, Anatomy and Genetics,</institution>
<institution>Oxford University,</institution>
</institution-wrap>
Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Levy, Finn Olav" sort="Levy, Finn Olav" uniqKey="Levy F" first="Finn Olav" last="Levy">Finn Olav Levy</name>
<affiliation wicri:level="1"><nlm:aff id="Aff73"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff74"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Andressen, Kjetil Wessel" sort="Andressen, Kjetil Wessel" uniqKey="Andressen K" first="Kjetil Wessel" last="Andressen">Kjetil Wessel Andressen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff73"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff74"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aue, Annemarie" sort="Aue, Annemarie" uniqKey="Aue A" first="Annemarie" last="Aue">Annemarie Aue</name>
<affiliation wicri:level="1"><nlm:aff id="Aff77"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schwiering, Fabian" sort="Schwiering, Fabian" uniqKey="Schwiering F" first="Fabian" last="Schwiering">Fabian Schwiering</name>
<affiliation wicri:level="1"><nlm:aff id="Aff77"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Groneberg, Dieter" sort="Groneberg, Dieter" uniqKey="Groneberg D" first="Dieter" last="Groneberg">Dieter Groneberg</name>
<affiliation wicri:level="1"><nlm:aff id="Aff77"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Friebe, Andreas" sort="Friebe, Andreas" uniqKey="Friebe A" first="Andreas" last="Friebe">Andreas Friebe</name>
<affiliation wicri:level="1"><nlm:aff id="Aff77"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bajraktari, Gzona" sort="Bajraktari, Gzona" uniqKey="Bajraktari G" first="Gzona" last="Bajraktari">Gzona Bajraktari</name>
<affiliation wicri:level="1"><nlm:aff id="Aff78"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 4373</institution-id>
<institution-id institution-id-type="GRID">grid.7700.0</institution-id>
<institution>Department of Clinical Pharmacology and Pharmacoepidemiology,</institution>
<institution>University of Heidelberg,</institution>
</institution-wrap>
Im Neuenheimer Feld 410, 69120 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Im Neuenheimer Feld 410, 69120 Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Burhenne, Jurgen" sort="Burhenne, Jurgen" uniqKey="Burhenne J" first="Jürgen" last="Burhenne">Jürgen Burhenne</name>
<affiliation wicri:level="1"><nlm:aff id="Aff78"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 4373</institution-id>
<institution-id institution-id-type="GRID">grid.7700.0</institution-id>
<institution>Department of Clinical Pharmacology and Pharmacoepidemiology,</institution>
<institution>University of Heidelberg,</institution>
</institution-wrap>
Im Neuenheimer Feld 410, 69120 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Im Neuenheimer Feld 410, 69120 Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haefeli, Walter E" sort="Haefeli, Walter E" uniqKey="Haefeli W" first="Walter E." last="Haefeli">Walter E. Haefeli</name>
<affiliation wicri:level="1"><nlm:aff id="Aff78"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 4373</institution-id>
<institution-id institution-id-type="GRID">grid.7700.0</institution-id>
<institution>Department of Clinical Pharmacology and Pharmacoepidemiology,</institution>
<institution>University of Heidelberg,</institution>
</institution-wrap>
Im Neuenheimer Feld 410, 69120 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Im Neuenheimer Feld 410, 69120 Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Weiss, Johanna" sort="Weiss, Johanna" uniqKey="Weiss J" first="Johanna" last="Weiss">Johanna Weiss</name>
<affiliation wicri:level="1"><nlm:aff id="Aff78"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 4373</institution-id>
<institution-id institution-id-type="GRID">grid.7700.0</institution-id>
<institution>Department of Clinical Pharmacology and Pharmacoepidemiology,</institution>
<institution>University of Heidelberg,</institution>
</institution-wrap>
Im Neuenheimer Feld 410, 69120 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Im Neuenheimer Feld 410, 69120 Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Beck, Katharina" sort="Beck, Katharina" uniqKey="Beck K" first="Katharina" last="Beck">Katharina Beck</name>
<affiliation wicri:level="1"><nlm:aff id="Aff79"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Voussen, Barbara" sort="Voussen, Barbara" uniqKey="Voussen B" first="Barbara" last="Voussen">Barbara Voussen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff79"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vincent, Alexander" sort="Vincent, Alexander" uniqKey="Vincent A" first="Alexander" last="Vincent">Alexander Vincent</name>
<affiliation wicri:level="1"><nlm:aff id="Aff80"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8227</institution-id>
<institution-id institution-id-type="GRID">grid.25073.33</institution-id>
<institution>Farncombe Family Digestive Health Research Institute,</institution>
<institution>McMaster University,</institution>
</institution-wrap>
Hamilton, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Hamilton</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Parsons, Sean P" sort="Parsons, Sean P" uniqKey="Parsons S" first="Sean P." last="Parsons">Sean P. Parsons</name>
<affiliation wicri:level="1"><nlm:aff id="Aff80"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8227</institution-id>
<institution-id institution-id-type="GRID">grid.25073.33</institution-id>
<institution>Farncombe Family Digestive Health Research Institute,</institution>
<institution>McMaster University,</institution>
</institution-wrap>
Hamilton, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Hamilton</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huizinga, Jan D" sort="Huizinga, Jan D" uniqKey="Huizinga J" first="Jan D." last="Huizinga">Jan D. Huizinga</name>
<affiliation wicri:level="1"><nlm:aff id="Aff80"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8227</institution-id>
<institution-id institution-id-type="GRID">grid.25073.33</institution-id>
<institution>Farncombe Family Digestive Health Research Institute,</institution>
<institution>McMaster University,</institution>
</institution-wrap>
Hamilton, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Hamilton</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Friebe, Andreas" sort="Friebe, Andreas" uniqKey="Friebe A" first="Andreas" last="Friebe">Andreas Friebe</name>
<affiliation wicri:level="1"><nlm:aff id="Aff79"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="M Nica, Fabiola Zakia" sort="M Nica, Fabiola Zakia" uniqKey="M Nica F" first="Fabiola Zakia" last="M Nica">Fabiola Zakia M Nica</name>
<affiliation wicri:level="2"><nlm:aff id="Aff81"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9510</institution-id>
<institution-id institution-id-type="GRID">grid.253615.6</institution-id>
<institution>Department of Biochemistry and Molecular Medicine,</institution>
<institution>George Washington University, School of Medicine,</institution>
</institution-wrap>
Washington, DC USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">District de Columbia</region>
</placeName>
<wicri:cityArea>Washington</wicri:cityArea>
</affiliation>
<affiliation><nlm:aff id="Aff82"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0723 2494</institution-id>
<institution-id institution-id-type="GRID">grid.411087.b</institution-id>
<institution>Department of Pharmacology, Faculty of Medical Sciences,</institution>
<institution>State University of Campinas (UNICAMP),</institution>
</institution-wrap>
Campinas, Sao Paolo Brazil</nlm:aff>
<wicri:noCountry code="subfield">Sao Paolo Brazil</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Seto, Edward" sort="Seto, Edward" uniqKey="Seto E" first="Edward" last="Seto">Edward Seto</name>
<affiliation wicri:level="2"><nlm:aff id="Aff81"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9510</institution-id>
<institution-id institution-id-type="GRID">grid.253615.6</institution-id>
<institution>Department of Biochemistry and Molecular Medicine,</institution>
<institution>George Washington University, School of Medicine,</institution>
</institution-wrap>
Washington, DC USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">District de Columbia</region>
</placeName>
<wicri:cityArea>Washington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Murad, Ferid" sort="Murad, Ferid" uniqKey="Murad F" first="Ferid" last="Murad">Ferid Murad</name>
<affiliation wicri:level="2"><nlm:aff id="Aff81"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9510</institution-id>
<institution-id institution-id-type="GRID">grid.253615.6</institution-id>
<institution>Department of Biochemistry and Molecular Medicine,</institution>
<institution>George Washington University, School of Medicine,</institution>
</institution-wrap>
Washington, DC USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">District de Columbia</region>
</placeName>
<wicri:cityArea>Washington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bian, Ka" sort="Bian, Ka" uniqKey="Bian K" first="Ka" last="Bian">Ka Bian</name>
<affiliation wicri:level="2"><nlm:aff id="Aff81"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9510</institution-id>
<institution-id institution-id-type="GRID">grid.253615.6</institution-id>
<institution>Department of Biochemistry and Molecular Medicine,</institution>
<institution>George Washington University, School of Medicine,</institution>
</institution-wrap>
Washington, DC USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">District de Columbia</region>
</placeName>
<wicri:cityArea>Washington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Burgoyne, Joseph R" sort="Burgoyne, Joseph R" uniqKey="Burgoyne J" first="Joseph R." last="Burgoyne">Joseph R. Burgoyne</name>
<affiliation><nlm:aff id="Aff83"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>King’s College London, Cardiovascular Division, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas’ Hospital,</institution>
</institution-wrap>
London, SE1 7EH UK</nlm:aff>
<wicri:noCountry code="subfield">SE1 7EH UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Prysyazhna, Oleksandra" sort="Prysyazhna, Oleksandra" uniqKey="Prysyazhna O" first="Oleksandra" last="Prysyazhna">Oleksandra Prysyazhna</name>
<affiliation><nlm:aff id="Aff83"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>King’s College London, Cardiovascular Division, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas’ Hospital,</institution>
</institution-wrap>
London, SE1 7EH UK</nlm:aff>
<wicri:noCountry code="subfield">SE1 7EH UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Richards, Daniel" sort="Richards, Daniel" uniqKey="Richards D" first="Daniel" last="Richards">Daniel Richards</name>
<affiliation><nlm:aff id="Aff83"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>King’s College London, Cardiovascular Division, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas’ Hospital,</institution>
</institution-wrap>
London, SE1 7EH UK</nlm:aff>
<wicri:noCountry code="subfield">SE1 7EH UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Eaton, Philip" sort="Eaton, Philip" uniqKey="Eaton P" first="Philip" last="Eaton">Philip Eaton</name>
<affiliation><nlm:aff id="Aff83"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>King’s College London, Cardiovascular Division, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas’ Hospital,</institution>
</institution-wrap>
London, SE1 7EH UK</nlm:aff>
<wicri:noCountry code="subfield">SE1 7EH UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Calamera, Gaia" sort="Calamera, Gaia" uniqKey="Calamera G" first="Gaia" last="Calamera">Gaia Calamera</name>
<affiliation wicri:level="1"><nlm:aff id="Aff84"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff85"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bj Rnerem, Marianne" sort="Bj Rnerem, Marianne" uniqKey="Bj Rnerem M" first="Marianne" last="Bj Rnerem">Marianne Bj Rnerem</name>
<affiliation wicri:level="1"><nlm:aff id="Aff84"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff85"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ulsund, Andrea Hembre" sort="Ulsund, Andrea Hembre" uniqKey="Ulsund A" first="Andrea Hembre" last="Ulsund">Andrea Hembre Ulsund</name>
<affiliation wicri:level="1"><nlm:aff id="Aff84"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff85"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kim, Jeong Joo" sort="Kim, Jeong Joo" uniqKey="Kim J" first="Jeong Joo" last="Kim">Jeong Joo Kim</name>
<affiliation><nlm:aff id="Aff86"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, Texas USA</nlm:aff>
<wicri:noCountry code="subfield">Texas USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kim, Choel" sort="Kim, Choel" uniqKey="Kim C" first="Choel" last="Kim">Choel Kim</name>
<affiliation><nlm:aff id="Aff86"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, Texas USA</nlm:aff>
<wicri:noCountry code="subfield">Texas USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Levy, Finn Olav" sort="Levy, Finn Olav" uniqKey="Levy F" first="Finn Olav" last="Levy">Finn Olav Levy</name>
<affiliation wicri:level="1"><nlm:aff id="Aff84"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff85"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Andressen, Kjetil Wessel" sort="Andressen, Kjetil Wessel" uniqKey="Andressen K" first="Kjetil Wessel" last="Andressen">Kjetil Wessel Andressen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff84"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff85"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Donzelli, Sonia" sort="Donzelli, Sonia" uniqKey="Donzelli S" first="Sonia" last="Donzelli">Sonia Donzelli</name>
<affiliation wicri:level="1"><nlm:aff id="Aff87"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center,</institution>
<institution>University, Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff88"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Goetz, Mara" sort="Goetz, Mara" uniqKey="Goetz M" first="Mara" last="Goetz">Mara Goetz</name>
<affiliation wicri:level="1"><nlm:aff id="Aff87"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center,</institution>
<institution>University, Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff88"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmidt, Kjestine" sort="Schmidt, Kjestine" uniqKey="Schmidt K" first="Kjestine" last="Schmidt">Kjestine Schmidt</name>
<affiliation wicri:level="1"><nlm:aff id="Aff88"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff89"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0057 2672</institution-id>
<institution-id institution-id-type="GRID">grid.4562.5</institution-id>
<institution>Department of Physiology,</institution>
<institution>University of Lübeck, DZHK Partner Site Hamburg/Kiel/Lübeck, University Heart Centre Lübeck,</institution>
</institution-wrap>
Lübeck, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Lübeck</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wolters, Markus" sort="Wolters, Markus" uniqKey="Wolters M" first="Markus" last="Wolters">Markus Wolters</name>
<affiliation wicri:level="1"><nlm:aff id="Aff90"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Hoppe-Seyler-Str. 4, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hoppe-Seyler-Str. 4, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stathopoulou, Konstantina" sort="Stathopoulou, Konstantina" uniqKey="Stathopoulou K" first="Konstantina" last="Stathopoulou">Konstantina Stathopoulou</name>
<affiliation wicri:level="1"><nlm:aff id="Aff87"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center,</institution>
<institution>University, Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff88"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Prysyazhna, Oleksandra" sort="Prysyazhna, Oleksandra" uniqKey="Prysyazhna O" first="Oleksandra" last="Prysyazhna">Oleksandra Prysyazhna</name>
<affiliation wicri:level="1"><nlm:aff id="Aff91"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>King’s College London, Cardiovascular Division, British Heart Foundation Centre of Excellence,</institution>
<institution>the Rayne Institute, St Thomas´ Hospital,</institution>
</institution-wrap>
SE17EH, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>SE17EH, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Scotcher, Jenna" sort="Scotcher, Jenna" uniqKey="Scotcher J" first="Jenna" last="Scotcher">Jenna Scotcher</name>
<affiliation wicri:level="1"><nlm:aff id="Aff91"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>King’s College London, Cardiovascular Division, British Heart Foundation Centre of Excellence,</institution>
<institution>the Rayne Institute, St Thomas´ Hospital,</institution>
</institution-wrap>
SE17EH, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>SE17EH, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dees, Christian" sort="Dees, Christian" uniqKey="Dees C" first="Christian" last="Dees">Christian Dees</name>
<affiliation wicri:level="1"><nlm:aff id="Aff92">Institute of Experimental Biomedicine II, University Medical Center Würzburg, Grombühlstraße 12, 97080 Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Experimental Biomedicine II, University Medical Center Würzburg, Grombühlstraße 12, 97080 Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Subramanian, Hariharan" sort="Subramanian, Hariharan" uniqKey="Subramanian H" first="Hariharan" last="Subramanian">Hariharan Subramanian</name>
<affiliation wicri:level="1"><nlm:aff id="Aff88"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff93"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Institute of Experimental Cardiovascular Research,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Butt, Elke" sort="Butt, Elke" uniqKey="Butt E" first="Elke" last="Butt">Elke Butt</name>
<affiliation wicri:level="1"><nlm:aff id="Aff92">Institute of Experimental Biomedicine II, University Medical Center Würzburg, Grombühlstraße 12, 97080 Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Experimental Biomedicine II, University Medical Center Würzburg, Grombühlstraße 12, 97080 Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kamynina, Alisa" sort="Kamynina, Alisa" uniqKey="Kamynina A" first="Alisa" last="Kamynina">Alisa Kamynina</name>
<affiliation wicri:level="1"><nlm:aff id="Aff91"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>King’s College London, Cardiovascular Division, British Heart Foundation Centre of Excellence,</institution>
<institution>the Rayne Institute, St Thomas´ Hospital,</institution>
</institution-wrap>
SE17EH, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>SE17EH, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bruce King, S" sort="Bruce King, S" uniqKey="Bruce King S" first="S." last="Bruce King">S. Bruce King</name>
<affiliation wicri:level="2"><nlm:aff id="Aff94"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2185 3318</institution-id>
<institution-id institution-id-type="GRID">grid.241167.7</institution-id>
<institution>Department of Chemistry,</institution>
<institution>Wake Forest University,</institution>
</institution-wrap>
Winston-Salem, North Carolina 27109 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Winston-Salem</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Nikolaev, Viacheslav O" sort="Nikolaev, Viacheslav O" uniqKey="Nikolaev V" first="Viacheslav O." last="Nikolaev">Viacheslav O. Nikolaev</name>
<affiliation wicri:level="1"><nlm:aff id="Aff88"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff93"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Institute of Experimental Cardiovascular Research,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Witt, Cor" sort="De Witt, Cor" uniqKey="De Witt C" first="Cor" last="De Witt">Cor De Witt</name>
<affiliation wicri:level="1"><nlm:aff id="Aff88"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff89"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0057 2672</institution-id>
<institution-id institution-id-type="GRID">grid.4562.5</institution-id>
<institution>Department of Physiology,</institution>
<institution>University of Lübeck, DZHK Partner Site Hamburg/Kiel/Lübeck, University Heart Centre Lübeck,</institution>
</institution-wrap>
Lübeck, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Lübeck</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Leichert, Lars I" sort="Leichert, Lars I" uniqKey="Leichert L" first="Lars I." last="Leichert">Lars I. Leichert</name>
<affiliation wicri:level="1"><nlm:aff id="Aff95"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Institute of Biochemistry and Pathobiochemistry - Microbial Biochemistry,</institution>
<institution>Ruhr University Bochum,</institution>
</institution-wrap>
Universitätsstrasse 150, 44780 Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Universitätsstrasse 150, 44780 Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Feil, Robert" sort="Feil, Robert" uniqKey="Feil R" first="Robert" last="Feil">Robert Feil</name>
<affiliation wicri:level="1"><nlm:aff id="Aff90"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Hoppe-Seyler-Str. 4, 72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hoppe-Seyler-Str. 4, 72076 Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eaton, Philip" sort="Eaton, Philip" uniqKey="Eaton P" first="Philip" last="Eaton">Philip Eaton</name>
<affiliation wicri:level="1"><nlm:aff id="Aff91"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>King’s College London, Cardiovascular Division, British Heart Foundation Centre of Excellence,</institution>
<institution>the Rayne Institute, St Thomas´ Hospital,</institution>
</institution-wrap>
SE17EH, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>SE17EH, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cuello, Friederike" sort="Cuello, Friederike" uniqKey="Cuello F" first="Friederike" last="Cuello">Friederike Cuello</name>
<affiliation wicri:level="1"><nlm:aff id="Aff87"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center,</institution>
<institution>University, Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff88"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Martinistrasse 52, 20246 Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dobrowinski, Hyazinth" sort="Dobrowinski, Hyazinth" uniqKey="Dobrowinski H" first="Hyazinth" last="Dobrowinski">Hyazinth Dobrowinski</name>
<affiliation wicri:level="1"><nlm:aff id="Aff96"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lehners, Moritz" sort="Lehners, Moritz" uniqKey="Lehners M" first="Moritz" last="Lehners">Moritz Lehners</name>
<affiliation wicri:level="1"><nlm:aff id="Aff96"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmidt, Michael Paolillo Hannes" sort="Schmidt, Michael Paolillo Hannes" uniqKey="Schmidt M" first="Michael Paolillo Hannes" last="Schmidt">Michael Paolillo Hannes Schmidt</name>
<affiliation wicri:level="1"><nlm:aff id="Aff96"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Feil, Robert" sort="Feil, Robert" uniqKey="Feil R" first="Robert" last="Feil">Robert Feil</name>
<affiliation wicri:level="1"><nlm:aff id="Aff96"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Feil, Susanne" sort="Feil, Susanne" uniqKey="Feil S" first="Susanne" last="Feil">Susanne Feil</name>
<affiliation wicri:level="1"><nlm:aff id="Aff97"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>Universität Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wen, Lai" sort="Wen, Lai" uniqKey="Wen L" first="Lai" last="Wen">Lai Wen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff97"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>Universität Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wolters, Markus" sort="Wolters, Markus" uniqKey="Wolters M" first="Markus" last="Wolters">Markus Wolters</name>
<affiliation wicri:level="1"><nlm:aff id="Aff97"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>Universität Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thunemann, Martin" sort="Thunemann, Martin" uniqKey="Thunemann M" first="Martin" last="Thunemann">Martin Thunemann</name>
<affiliation wicri:level="1"><nlm:aff id="Aff97"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>Universität Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmidt, Kjestine" sort="Schmidt, Kjestine" uniqKey="Schmidt K" first="Kjestine" last="Schmidt">Kjestine Schmidt</name>
<affiliation wicri:level="1"><nlm:aff id="Aff98"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0057 2672</institution-id>
<institution-id institution-id-type="GRID">grid.4562.5</institution-id>
<institution>Institut für Physiologie,</institution>
<institution>Universität zu Lübeck,</institution>
</institution-wrap>
Lübeck, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Lübeck</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Olbrich, Marcus" sort="Olbrich, Marcus" uniqKey="Olbrich M" first="Marcus" last="Olbrich">Marcus Olbrich</name>
<affiliation wicri:level="1"><nlm:aff id="Aff99"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Cardiology & Cardiovascular Medicine,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Langer, Harald" sort="Langer, Harald" uniqKey="Langer H" first="Harald" last="Langer">Harald Langer</name>
<affiliation wicri:level="1"><nlm:aff id="Aff99"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Cardiology & Cardiovascular Medicine,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gawaz, Meinrad" sort="Gawaz, Meinrad" uniqKey="Gawaz M" first="Meinrad" last="Gawaz">Meinrad Gawaz</name>
<affiliation wicri:level="1"><nlm:aff id="Aff99"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Cardiology & Cardiovascular Medicine,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Friebe, Andreas" sort="Friebe, Andreas" uniqKey="Friebe A" first="Andreas" last="Friebe">Andreas Friebe</name>
<affiliation wicri:level="1"><nlm:aff id="Aff100"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Wit, Cor" sort="De Wit, Cor" uniqKey="De Wit C" first="Cor" last="De Wit">Cor De Wit</name>
<affiliation wicri:level="1"><nlm:aff id="Aff98"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0057 2672</institution-id>
<institution-id institution-id-type="GRID">grid.4562.5</institution-id>
<institution>Institut für Physiologie,</institution>
<institution>Universität zu Lübeck,</institution>
</institution-wrap>
Lübeck, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Lübeck</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Feil, Robert" sort="Feil, Robert" uniqKey="Feil R" first="Robert" last="Feil">Robert Feil</name>
<affiliation wicri:level="1"><nlm:aff id="Aff97"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>Universität Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Franz, Eugen" sort="Franz, Eugen" uniqKey="Franz E" first="Eugen" last="Franz">Eugen Franz</name>
<affiliation wicri:level="1"><nlm:aff id="Aff101"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1089 1036</institution-id>
<institution-id institution-id-type="GRID">grid.5155.4</institution-id>
<institution>Department of Biochemistry,</institution>
<institution>University of Kassel,</institution>
</institution-wrap>
34132 Kassel, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>34132 Kassel</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kim, Jeong Joo" sort="Kim, Jeong Joo" uniqKey="Kim J" first="Jeong Joo" last="Kim">Jeong Joo Kim</name>
<affiliation wicri:level="1"><nlm:aff id="Aff101"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1089 1036</institution-id>
<institution-id institution-id-type="GRID">grid.5155.4</institution-id>
<institution>Department of Biochemistry,</institution>
<institution>University of Kassel,</institution>
</institution-wrap>
34132 Kassel, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>34132 Kassel</wicri:regionArea>
</affiliation>
<affiliation><nlm:aff id="Aff102"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
One Baylor Plaza, Houston, Texas USA</nlm:aff>
<wicri:noCountry code="subfield">Texas USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bertinetti, Daniela" sort="Bertinetti, Daniela" uniqKey="Bertinetti D" first="Daniela" last="Bertinetti">Daniela Bertinetti</name>
<affiliation wicri:level="1"><nlm:aff id="Aff101"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1089 1036</institution-id>
<institution-id institution-id-type="GRID">grid.5155.4</institution-id>
<institution>Department of Biochemistry,</institution>
<institution>University of Kassel,</institution>
</institution-wrap>
34132 Kassel, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>34132 Kassel</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kim, Choel" sort="Kim, Choel" uniqKey="Kim C" first="Choel" last="Kim">Choel Kim</name>
<affiliation><nlm:aff id="Aff102"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
One Baylor Plaza, Houston, Texas USA</nlm:aff>
<wicri:noCountry code="subfield">Texas USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Herberg, Friedrich W" sort="Herberg, Friedrich W" uniqKey="Herberg F" first="Friedrich W." last="Herberg">Friedrich W. Herberg</name>
<affiliation wicri:level="1"><nlm:aff id="Aff101"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1089 1036</institution-id>
<institution-id institution-id-type="GRID">grid.5155.4</institution-id>
<institution>Department of Biochemistry,</institution>
<institution>University of Kassel,</institution>
</institution-wrap>
34132 Kassel, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>34132 Kassel</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ghofrani, Hossein Ardeschir" sort="Ghofrani, Hossein Ardeschir" uniqKey="Ghofrani H" first="Hossein-Ardeschir" last="Ghofrani">Hossein-Ardeschir Ghofrani</name>
<affiliation wicri:level="1"><nlm:aff id="Aff103"><institution-wrap><institution-id institution-id-type="GRID">grid.440517.3</institution-id>
<institution>Department of Internal Medicine,</institution>
<institution>University of Giessen and Marburg Lung Center (UGMLC),</institution>
</institution-wrap>
Giessen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Giessen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Grimminger, Friedrich" sort="Grimminger, Friedrich" uniqKey="Grimminger F" first="Friedrich" last="Grimminger">Friedrich Grimminger</name>
<affiliation wicri:level="1"><nlm:aff id="Aff103"><institution-wrap><institution-id institution-id-type="GRID">grid.440517.3</institution-id>
<institution>Department of Internal Medicine,</institution>
<institution>University of Giessen and Marburg Lung Center (UGMLC),</institution>
</institution-wrap>
Giessen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Giessen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Grunig, Ekkehard" sort="Grunig, Ekkehard" uniqKey="Grunig E" first="Ekkehard" last="Grünig">Ekkehard Grünig</name>
<affiliation wicri:level="1"><nlm:aff id="Aff104"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0328 4908</institution-id>
<institution-id institution-id-type="GRID">grid.5253.1</institution-id>
<institution>Centre for Pulmonary Hypertension at the Thoraxclinic of University Hospital Heidelberg,</institution>
</institution-wrap>
Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huang, Yigao" sort="Huang, Yigao" uniqKey="Huang Y" first="Yigao" last="Huang">Yigao Huang</name>
<affiliation><nlm:aff id="Aff105"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1760 3705</institution-id>
<institution-id institution-id-type="GRID">grid.413352.2</institution-id>
<institution>Department of Cardiology, Guangdong General Hospital and Guangdong Cardiovascular Institute,</institution>
</institution-wrap>
Guangzhou, Guangdong China</nlm:aff>
<wicri:noCountry code="subfield">Guangdong China</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Jansa, Pavel" sort="Jansa, Pavel" uniqKey="Jansa P" first="Pavel" last="Jansa">Pavel Jansa</name>
<affiliation wicri:level="1"><nlm:aff id="Aff106"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9100 9940</institution-id>
<institution-id institution-id-type="GRID">grid.411798.2</institution-id>
<institution>Department of Cardiology and Angiology of the First Faculty of Medicine and General Teaching Hospital,</institution>
</institution-wrap>
Prague, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Prague</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jing, Zhi Cheng" sort="Jing, Zhi Cheng" uniqKey="Jing Z" first="Zhi Cheng" last="Jing">Zhi Cheng Jing</name>
<affiliation wicri:level="1"><nlm:aff id="Aff107"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0662 3178</institution-id>
<institution-id institution-id-type="GRID">grid.12527.33</institution-id>
<institution>State Key Laboratory of Cardiovascular Disease FuWai Hospital, National Center for Cardiovascular DiseasePeking Union Medical College and Chinese Academy of Medical Sciences,</institution>
</institution-wrap>
Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kilpatrick, David" sort="Kilpatrick, David" uniqKey="Kilpatrick D" first="David" last="Kilpatrick">David Kilpatrick</name>
<affiliation wicri:level="1"><nlm:aff id="Aff108"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 826X</institution-id>
<institution-id institution-id-type="GRID">grid.1009.8</institution-id>
<institution>Discipline of Medicine,</institution>
<institution>University of Tasmania,</institution>
</institution-wrap>
Hobart, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Hobart</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Langleben, David" sort="Langleben, David" uniqKey="Langleben D" first="David" last="Langleben">David Langleben</name>
<affiliation><nlm:aff id="Aff109"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8649</institution-id>
<institution-id institution-id-type="GRID">grid.14709.3b</institution-id>
<institution>Center for Pulmonary Vascular Disease,</institution>
<institution>McGill University,</institution>
</institution-wrap>
Montreal, QC Canada</nlm:aff>
<wicri:noCountry code="subfield">QC Canada</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Rosenkranz, Stephan" sort="Rosenkranz, Stephan" uniqKey="Rosenkranz S" first="Stephan" last="Rosenkranz">Stephan Rosenkranz</name>
<affiliation wicri:level="1"><nlm:aff id="Aff110"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8580 3777</institution-id>
<institution-id institution-id-type="GRID">grid.6190.e</institution-id>
<institution>Department III of Internal Medicine and Cologne Cardiovascular Research Centre,</institution>
<institution>Cologne University Heart Centre,</institution>
</institution-wrap>
Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Menezes, Flavia" sort="Menezes, Flavia" uniqKey="Menezes F" first="Flavia" last="Menezes">Flavia Menezes</name>
<affiliation wicri:level="1"><nlm:aff id="Aff111">Bayer HealthCare Pharmaceuticals, São Paulo, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Bayer HealthCare Pharmaceuticals, São Paulo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fritsch, Arno" sort="Fritsch, Arno" uniqKey="Fritsch A" first="Arno" last="Fritsch">Arno Fritsch</name>
<affiliation wicri:level="1"><nlm:aff id="Aff112"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Global Clinical Development, Bayer AG,</institution>
</institution-wrap>
Wuppertal, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Wuppertal</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nikkho, Sylvia" sort="Nikkho, Sylvia" uniqKey="Nikkho S" first="Sylvia" last="Nikkho">Sylvia Nikkho</name>
<affiliation wicri:level="1"><nlm:aff id="Aff113"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Global Clinical Development, Bayer AG,</institution>
</institution-wrap>
Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Frey, Reiner" sort="Frey, Reiner" uniqKey="Frey R" first="Reiner" last="Frey">Reiner Frey</name>
<affiliation wicri:level="1"><nlm:aff id="Aff113"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Global Clinical Development, Bayer AG,</institution>
</institution-wrap>
Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Humbert, Marc" sort="Humbert, Marc" uniqKey="Humbert M" first="Marc" last="Humbert">Marc Humbert</name>
<affiliation wicri:level="1"><nlm:aff id="Aff114"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 4910 6535</institution-id>
<institution-id institution-id-type="GRID">grid.460789.4</institution-id>
<institution>Université Paris-Sud,</institution>
<institution>Université Paris-Saclay,</institution>
</institution-wrap>
Le Kremlin Bicêtre, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Le Kremlin Bicêtre</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Groneberg, Dieter" sort="Groneberg, Dieter" uniqKey="Groneberg D" first="Dieter" last="Groneberg">Dieter Groneberg</name>
<affiliation wicri:level="1"><nlm:aff id="Aff115"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aue, Annemarie" sort="Aue, Annemarie" uniqKey="Aue A" first="Annemarie" last="Aue">Annemarie Aue</name>
<affiliation wicri:level="1"><nlm:aff id="Aff115"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schwiering, Fabian" sort="Schwiering, Fabian" uniqKey="Schwiering F" first="Fabian" last="Schwiering">Fabian Schwiering</name>
<affiliation wicri:level="1"><nlm:aff id="Aff115"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Friebe, Andreas" sort="Friebe, Andreas" uniqKey="Friebe A" first="Andreas" last="Friebe">Andreas Friebe</name>
<affiliation wicri:level="1"><nlm:aff id="Aff115"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Harloff, Manuela" sort="Harloff, Manuela" uniqKey="Harloff M" first="Manuela" last="Harloff">Manuela Harloff</name>
<affiliation wicri:level="1"><nlm:aff id="Aff116"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 5763</institution-id>
<institution-id institution-id-type="GRID">grid.7727.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Regensburg,</institution>
</institution-wrap>
93053 Regensburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>93053 Regensburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Reinders, Joerg" sort="Reinders, Joerg" uniqKey="Reinders J" first="Joerg" last="Reinders">Joerg Reinders</name>
<affiliation wicri:level="1"><nlm:aff id="Aff117"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 5763</institution-id>
<institution-id institution-id-type="GRID">grid.7727.5</institution-id>
<institution>Department Functional Genomics,</institution>
<institution>University of Regensburg,</institution>
</institution-wrap>
93053 Regensburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>93053 Regensburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schlossmann, Jens" sort="Schlossmann, Jens" uniqKey="Schlossmann J" first="Jens" last="Schlossmann">Jens Schlossmann</name>
<affiliation wicri:level="1"><nlm:aff id="Aff116"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 5763</institution-id>
<institution-id institution-id-type="GRID">grid.7727.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Regensburg,</institution>
</institution-wrap>
93053 Regensburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>93053 Regensburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jung, Joon" sort="Jung, Joon" uniqKey="Jung J" first="Joon" last="Jung">Joon Jung</name>
<affiliation wicri:level="2"><nlm:aff id="Aff118"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wales, Jessica A" sort="Wales, Jessica A" uniqKey="Wales J" first="Jessica A." last="Wales">Jessica A. Wales</name>
<affiliation><nlm:aff id="Aff119"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2168 186X</institution-id>
<institution-id institution-id-type="GRID">grid.134563.6</institution-id>
<institution>Department of Chemistry and Biochemistry,</institution>
<institution>University of Arizona,</institution>
</institution-wrap>
Tucson, AZ 8572 USA</nlm:aff>
<wicri:noCountry code="subfield">AZ 8572 USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Chen, Cheng Yu" sort="Chen, Cheng Yu" uniqKey="Chen C" first="Cheng-Yu" last="Chen">Cheng-Yu Chen</name>
<affiliation><nlm:aff id="Aff119"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2168 186X</institution-id>
<institution-id institution-id-type="GRID">grid.134563.6</institution-id>
<institution>Department of Chemistry and Biochemistry,</institution>
<institution>University of Arizona,</institution>
</institution-wrap>
Tucson, AZ 8572 USA</nlm:aff>
<wicri:noCountry code="subfield">AZ 8572 USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Breci, Linda" sort="Breci, Linda" uniqKey="Breci L" first="Linda" last="Breci">Linda Breci</name>
<affiliation><nlm:aff id="Aff119"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2168 186X</institution-id>
<institution-id institution-id-type="GRID">grid.134563.6</institution-id>
<institution>Department of Chemistry and Biochemistry,</institution>
<institution>University of Arizona,</institution>
</institution-wrap>
Tucson, AZ 8572 USA</nlm:aff>
<wicri:noCountry code="subfield">AZ 8572 USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Weichsel, Andrzej" sort="Weichsel, Andrzej" uniqKey="Weichsel A" first="Andrzej" last="Weichsel">Andrzej Weichsel</name>
<affiliation><nlm:aff id="Aff119"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2168 186X</institution-id>
<institution-id institution-id-type="GRID">grid.134563.6</institution-id>
<institution>Department of Chemistry and Biochemistry,</institution>
<institution>University of Arizona,</institution>
</institution-wrap>
Tucson, AZ 8572 USA</nlm:aff>
<wicri:noCountry code="subfield">AZ 8572 USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bernier, Sylvie G" sort="Bernier, Sylvie G" uniqKey="Bernier S" first="Sylvie G." last="Bernier">Sylvie G. Bernier</name>
<affiliation wicri:level="2"><nlm:aff id="Aff118"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Solinga, Robert" sort="Solinga, Robert" uniqKey="Solinga R" first="Robert" last="Solinga">Robert Solinga</name>
<affiliation wicri:level="2"><nlm:aff id="Aff118"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sheppeck, James E" sort="Sheppeck, James E" uniqKey="Sheppeck J" first="James E." last="Sheppeck">James E. Sheppeck</name>
<affiliation wicri:level="2"><nlm:aff id="Aff118"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Renhowe, Paul A" sort="Renhowe, Paul A" uniqKey="Renhowe P" first="Paul A." last="Renhowe">Paul A. Renhowe</name>
<affiliation wicri:level="2"><nlm:aff id="Aff118"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Montfort, William R" sort="Montfort, William R" uniqKey="Montfort W" first="William R." last="Montfort">William R. Montfort</name>
<affiliation><nlm:aff id="Aff119"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2168 186X</institution-id>
<institution-id institution-id-type="GRID">grid.134563.6</institution-id>
<institution>Department of Chemistry and Biochemistry,</institution>
<institution>University of Arizona,</institution>
</institution-wrap>
Tucson, AZ 8572 USA</nlm:aff>
<wicri:noCountry code="subfield">AZ 8572 USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Qin, Liying" sort="Qin, Liying" uniqKey="Qin L" first="Liying" last="Qin">Liying Qin</name>
<affiliation><nlm:aff id="Aff120"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Verna and Marrs McLean Department of Biochemistry and Molecular Biology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, Texas USA</nlm:aff>
<wicri:noCountry code="subfield">Texas USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sung, Ying Ju" sort="Sung, Ying Ju" uniqKey="Sung Y" first="Ying-Ju" last="Sung">Ying-Ju Sung</name>
<affiliation wicri:level="2"><nlm:aff id="Aff121"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0448 6255</institution-id>
<institution-id institution-id-type="GRID">grid.414627.2</institution-id>
<institution>Geisinger Commonwealth School of Medicine, Commonwealth Medical College,</institution>
</institution-wrap>
Scranton, PA 18509 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Scranton</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Casteel, Darren" sort="Casteel, Darren" uniqKey="Casteel D" first="Darren" last="Casteel">Darren Casteel</name>
<affiliation wicri:level="1"><nlm:aff id="Aff122"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2181 7878</institution-id>
<institution-id institution-id-type="GRID">grid.47840.3f</institution-id>
<institution>Department of Medicine,</institution>
<institution>University of California,</institution>
</institution-wrap>
San Diego, La Jolla, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>San Diego, La Jolla, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kim, Choel" sort="Kim, Choel" uniqKey="Kim C" first="Choel" last="Kim">Choel Kim</name>
<affiliation><nlm:aff id="Aff120"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Verna and Marrs McLean Department of Biochemistry and Molecular Biology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, Texas USA</nlm:aff>
<wicri:noCountry code="subfield">Texas USA</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff123"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, Texas USA</nlm:aff>
<wicri:noCountry code="subfield">Texas USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kollau, Alexander" sort="Kollau, Alexander" uniqKey="Kollau A" first="Alexander" last="Kollau">Alexander Kollau</name>
<affiliation wicri:level="1"><nlm:aff id="Aff124"><institution-wrap><institution-id institution-id-type="ISNI">0000000121539003</institution-id>
<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
A 8010, Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A 8010, Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Neubauer, Andrea" sort="Neubauer, Andrea" uniqKey="Neubauer A" first="Andrea" last="Neubauer">Andrea Neubauer</name>
<affiliation wicri:level="1"><nlm:aff id="Aff124"><institution-wrap><institution-id institution-id-type="ISNI">0000000121539003</institution-id>
<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
A 8010, Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A 8010, Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schrammel, Astrid" sort="Schrammel, Astrid" uniqKey="Schrammel A" first="Astrid" last="Schrammel">Astrid Schrammel</name>
<affiliation wicri:level="1"><nlm:aff id="Aff124"><institution-wrap><institution-id institution-id-type="ISNI">0000000121539003</institution-id>
<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
A 8010, Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A 8010, Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Russwurm, Michael" sort="Russwurm, Michael" uniqKey="Russwurm M" first="Michael" last="Russwurm">Michael Russwurm</name>
<affiliation wicri:level="1"><nlm:aff id="Aff125"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>Ruhr University Bochum,</institution>
</institution-wrap>
D 44780 Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>D 44780 Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koesling, Doris" sort="Koesling, Doris" uniqKey="Koesling D" first="Doris" last="Koesling">Doris Koesling</name>
<affiliation wicri:level="1"><nlm:aff id="Aff125"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>Ruhr University Bochum,</institution>
</institution-wrap>
D 44780 Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>D 44780 Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mayer, Bernd" sort="Mayer, Bernd" uniqKey="Mayer B" first="Bernd" last="Mayer">Bernd Mayer</name>
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<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
A 8010, Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A 8010, Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kumazoe, Motofumi" sort="Kumazoe, Motofumi" uniqKey="Kumazoe M" first="Motofumi" last="Kumazoe">Motofumi Kumazoe</name>
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<institution-id institution-id-type="GRID">grid.177174.3</institution-id>
<institution>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture,</institution>
<institution>Kyushu University,</institution>
</institution-wrap>
6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581 Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>6-10-1 Hakozaki, Higashi-ku, Fukuoka</wicri:regionArea>
</affiliation>
<affiliation><nlm:aff id="Aff127"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
5-7-1 Fujishiro-dai, Suita-City, Osaka 565-8565 Japan</nlm:aff>
<wicri:noCountry code="subfield">Osaka 565-8565 Japan</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Takai, Mika" sort="Takai, Mika" uniqKey="Takai M" first="Mika" last="Takai">Mika Takai</name>
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<institution-id institution-id-type="GRID">grid.177174.3</institution-id>
<institution>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture,</institution>
<institution>Kyushu University,</institution>
</institution-wrap>
6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581 Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>6-10-1 Hakozaki, Higashi-ku, Fukuoka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Takeuchi, Chieri" sort="Takeuchi, Chieri" uniqKey="Takeuchi C" first="Chieri" last="Takeuchi">Chieri Takeuchi</name>
<affiliation wicri:level="1"><nlm:aff id="Aff126"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2242 4849</institution-id>
<institution-id institution-id-type="GRID">grid.177174.3</institution-id>
<institution>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture,</institution>
<institution>Kyushu University,</institution>
</institution-wrap>
6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581 Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>6-10-1 Hakozaki, Higashi-ku, Fukuoka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kadomatsu, Mai" sort="Kadomatsu, Mai" uniqKey="Kadomatsu M" first="Mai" last="Kadomatsu">Mai Kadomatsu</name>
<affiliation wicri:level="1"><nlm:aff id="Aff126"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2242 4849</institution-id>
<institution-id institution-id-type="GRID">grid.177174.3</institution-id>
<institution>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture,</institution>
<institution>Kyushu University,</institution>
</institution-wrap>
6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581 Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>6-10-1 Hakozaki, Higashi-ku, Fukuoka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hiroi, Shun" sort="Hiroi, Shun" uniqKey="Hiroi S" first="Shun" last="Hiroi">Shun Hiroi</name>
<affiliation wicri:level="1"><nlm:aff id="Aff126"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2242 4849</institution-id>
<institution-id institution-id-type="GRID">grid.177174.3</institution-id>
<institution>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture,</institution>
<institution>Kyushu University,</institution>
</institution-wrap>
6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581 Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>6-10-1 Hakozaki, Higashi-ku, Fukuoka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Takamatsu, Kanako" sort="Takamatsu, Kanako" uniqKey="Takamatsu K" first="Kanako" last="Takamatsu">Kanako Takamatsu</name>
<affiliation wicri:level="1"><nlm:aff id="Aff126"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2242 4849</institution-id>
<institution-id institution-id-type="GRID">grid.177174.3</institution-id>
<institution>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture,</institution>
<institution>Kyushu University,</institution>
</institution-wrap>
6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581 Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>6-10-1 Hakozaki, Higashi-ku, Fukuoka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nojiri, Takashi" sort="Nojiri, Takashi" uniqKey="Nojiri T" first="Takashi" last="Nojiri">Takashi Nojiri</name>
<affiliation><nlm:aff id="Aff127"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
5-7-1 Fujishiro-dai, Suita-City, Osaka 565-8565 Japan</nlm:aff>
<wicri:noCountry code="subfield">Osaka 565-8565 Japan</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kangawa, Kenji" sort="Kangawa, Kenji" uniqKey="Kangawa K" first="Kenji" last="Kangawa">Kenji Kangawa</name>
<affiliation><nlm:aff id="Aff127"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
5-7-1 Fujishiro-dai, Suita-City, Osaka 565-8565 Japan</nlm:aff>
<wicri:noCountry code="subfield">Osaka 565-8565 Japan</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Tachibana, Hirofumi" sort="Tachibana, Hirofumi" uniqKey="Tachibana H" first="Hirofumi" last="Tachibana">Hirofumi Tachibana</name>
<affiliation wicri:level="1"><nlm:aff id="Aff126"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2242 4849</institution-id>
<institution-id institution-id-type="GRID">grid.177174.3</institution-id>
<institution>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture,</institution>
<institution>Kyushu University,</institution>
</institution-wrap>
6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581 Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>6-10-1 Hakozaki, Higashi-ku, Fukuoka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Opelt, Marissa" sort="Opelt, Marissa" uniqKey="Opelt M" first="Marissa" last="Opelt">Marissa Opelt</name>
<affiliation wicri:level="1"><nlm:aff id="Aff128"><institution-wrap><institution-id institution-id-type="ISNI">0000000121539003</institution-id>
<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Institute of Pharmaceutical Sciences, Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eroglu, Emrah" sort="Eroglu, Emrah" uniqKey="Eroglu E" first="Emrah" last="Eroglu">Emrah Eroglu</name>
<affiliation wicri:level="1"><nlm:aff id="Aff129"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8988 2476</institution-id>
<institution-id institution-id-type="GRID">grid.11598.34</institution-id>
<institution>Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine,</institution>
<institution>Medical University of Graz,</institution>
</institution-wrap>
Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Waldeck Weiermair, Markus" sort="Waldeck Weiermair, Markus" uniqKey="Waldeck Weiermair M" first="Markus" last="Waldeck-Weiermair">Markus Waldeck-Weiermair</name>
<affiliation wicri:level="1"><nlm:aff id="Aff129"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8988 2476</institution-id>
<institution-id institution-id-type="GRID">grid.11598.34</institution-id>
<institution>Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine,</institution>
<institution>Medical University of Graz,</institution>
</institution-wrap>
Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Russwurm, Michael" sort="Russwurm, Michael" uniqKey="Russwurm M" first="Michael" last="Russwurm">Michael Russwurm</name>
<affiliation wicri:level="1"><nlm:aff id="Aff130"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>Ruhr University Bochum,</institution>
</institution-wrap>
Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koesling, Doris" sort="Koesling, Doris" uniqKey="Koesling D" first="Doris" last="Koesling">Doris Koesling</name>
<affiliation wicri:level="1"><nlm:aff id="Aff130"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>Ruhr University Bochum,</institution>
</institution-wrap>
Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Malli, Roland" sort="Malli, Roland" uniqKey="Malli R" first="Roland" last="Malli">Roland Malli</name>
<affiliation wicri:level="1"><nlm:aff id="Aff129"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8988 2476</institution-id>
<institution-id institution-id-type="GRID">grid.11598.34</institution-id>
<institution>Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine,</institution>
<institution>Medical University of Graz,</institution>
</institution-wrap>
Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Graier, Wolfgang F" sort="Graier, Wolfgang F" uniqKey="Graier W" first="Wolfgang F." last="Graier">Wolfgang F. Graier</name>
<affiliation wicri:level="1"><nlm:aff id="Aff129"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8988 2476</institution-id>
<institution-id institution-id-type="GRID">grid.11598.34</institution-id>
<institution>Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine,</institution>
<institution>Medical University of Graz,</institution>
</institution-wrap>
Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fassett, John T" sort="Fassett, John T" uniqKey="Fassett J" first="John T." last="Fassett">John T. Fassett</name>
<affiliation wicri:level="1"><nlm:aff id="Aff128"><institution-wrap><institution-id institution-id-type="ISNI">0000000121539003</institution-id>
<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Institute of Pharmaceutical Sciences, Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schrammel, Astrid" sort="Schrammel, Astrid" uniqKey="Schrammel A" first="Astrid" last="Schrammel">Astrid Schrammel</name>
<affiliation wicri:level="1"><nlm:aff id="Aff128"><institution-wrap><institution-id institution-id-type="ISNI">0000000121539003</institution-id>
<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Institute of Pharmaceutical Sciences, Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mayer, Bernd" sort="Mayer, Bernd" uniqKey="Mayer B" first="Bernd" last="Mayer">Bernd Mayer</name>
<affiliation wicri:level="1"><nlm:aff id="Aff128"><institution-wrap><institution-id institution-id-type="ISNI">0000000121539003</institution-id>
<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Institute of Pharmaceutical Sciences, Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sollie, Selene J" sort="Sollie, Selene J" uniqKey="Sollie S" first="Selene J." last="Sollie">Selene J. Sollie</name>
<affiliation wicri:level="1"><nlm:aff id="Aff131"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology, Faculty of Medicine,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff132"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research, Faculty of Medicine,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Moltzau, Lise Roman" sort="Moltzau, Lise Roman" uniqKey="Moltzau L" first="Lise Román" last="Moltzau">Lise Román Moltzau</name>
<affiliation wicri:level="1"><nlm:aff id="Aff131"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology, Faculty of Medicine,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff132"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research, Faculty of Medicine,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hernandez Valladares, Maria" sort="Hernandez Valladares, Maria" uniqKey="Hernandez Valladares M" first="Maria" last="Hernandez-Valladares">Maria Hernandez-Valladares</name>
<affiliation wicri:level="1"><nlm:aff id="Aff133"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7443</institution-id>
<institution-id institution-id-type="GRID">grid.7914.b</institution-id>
<institution>Department of Biomedicine, Faculty of Medicine and Dentistry,</institution>
<institution>University of Bergen,</institution>
</institution-wrap>
Bergen, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Bergen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Berven, Frode" sort="Berven, Frode" uniqKey="Berven F" first="Frode" last="Berven">Frode Berven</name>
<affiliation wicri:level="1"><nlm:aff id="Aff133"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7443</institution-id>
<institution-id institution-id-type="GRID">grid.7914.b</institution-id>
<institution>Department of Biomedicine, Faculty of Medicine and Dentistry,</institution>
<institution>University of Bergen,</institution>
</institution-wrap>
Bergen, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Bergen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Levy, Finn Olav" sort="Levy, Finn Olav" uniqKey="Levy F" first="Finn Olav" last="Levy">Finn Olav Levy</name>
<affiliation wicri:level="1"><nlm:aff id="Aff131"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology, Faculty of Medicine,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff132"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research, Faculty of Medicine,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Andressen, Kjetil W" sort="Andressen, Kjetil W" uniqKey="Andressen K" first="Kjetil W." last="Andressen">Kjetil W. Andressen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff131"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology, Faculty of Medicine,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff132"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research, Faculty of Medicine,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nojiri, Takashi" sort="Nojiri, Takashi" uniqKey="Nojiri T" first="Takashi" last="Nojiri">Takashi Nojiri</name>
<affiliation wicri:level="1"><nlm:aff id="Aff134"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff135"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0373 3971</institution-id>
<institution-id institution-id-type="GRID">grid.136593.b</institution-id>
<institution>Department of General Thoracic Surgery,</institution>
<institution>Osaka University Graduate School of Medicine,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tokudome, Takeshi" sort="Tokudome, Takeshi" uniqKey="Tokudome T" first="Takeshi" last="Tokudome">Takeshi Tokudome</name>
<affiliation wicri:level="1"><nlm:aff id="Aff134"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kumazoe, Motofumi" sort="Kumazoe, Motofumi" uniqKey="Kumazoe M" first="Motofumi" last="Kumazoe">Motofumi Kumazoe</name>
<affiliation wicri:level="1"><nlm:aff id="Aff134"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arai, Miki" sort="Arai, Miki" uniqKey="Arai M" first="Miki" last="Arai">Miki Arai</name>
<affiliation wicri:level="1"><nlm:aff id="Aff136"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 1583</institution-id>
<institution-id institution-id-type="GRID">grid.418163.9</institution-id>
<institution>Advanced Telecommunications Research Institute International (ATR), The Thomas N. Sato BioMEC-X Laboratories,</institution>
</institution-wrap>
Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Kyoto</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff137"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2151 536X</institution-id>
<institution-id institution-id-type="GRID">grid.26999.3d</institution-id>
<institution>The University of Tokyo, graduate school of frontier science,</institution>
</institution-wrap>
Kashiwa, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Kashiwa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Suzuki, Yutaka" sort="Suzuki, Yutaka" uniqKey="Suzuki Y" first="Yutaka" last="Suzuki">Yutaka Suzuki</name>
<affiliation wicri:level="1"><nlm:aff id="Aff137"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2151 536X</institution-id>
<institution-id institution-id-type="GRID">grid.26999.3d</institution-id>
<institution>The University of Tokyo, graduate school of frontier science,</institution>
</institution-wrap>
Kashiwa, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Kashiwa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Miura, Koichi" sort="Miura, Koichi" uniqKey="Miura K" first="Koichi" last="Miura">Koichi Miura</name>
<affiliation wicri:level="1"><nlm:aff id="Aff134"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hino, Jun" sort="Hino, Jun" uniqKey="Hino J" first="Jun" last="Hino">Jun Hino</name>
<affiliation wicri:level="1"><nlm:aff id="Aff134"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hosoda, Hiroshi" sort="Hosoda, Hiroshi" uniqKey="Hosoda H" first="Hiroshi" last="Hosoda">Hiroshi Hosoda</name>
<affiliation wicri:level="1"><nlm:aff id="Aff138"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Miyazato, Mikiya" sort="Miyazato, Mikiya" uniqKey="Miyazato M" first="Mikiya" last="Miyazato">Mikiya Miyazato</name>
<affiliation wicri:level="1"><nlm:aff id="Aff134"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Okumura, Meinoshin" sort="Okumura, Meinoshin" uniqKey="Okumura M" first="Meinoshin" last="Okumura">Meinoshin Okumura</name>
<affiliation wicri:level="1"><nlm:aff id="Aff135"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0373 3971</institution-id>
<institution-id institution-id-type="GRID">grid.136593.b</institution-id>
<institution>Department of General Thoracic Surgery,</institution>
<institution>Osaka University Graduate School of Medicine,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kawaoka, Shinpei" sort="Kawaoka, Shinpei" uniqKey="Kawaoka S" first="Shinpei" last="Kawaoka">Shinpei Kawaoka</name>
<affiliation wicri:level="1"><nlm:aff id="Aff136"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 1583</institution-id>
<institution-id institution-id-type="GRID">grid.418163.9</institution-id>
<institution>Advanced Telecommunications Research Institute International (ATR), The Thomas N. Sato BioMEC-X Laboratories,</institution>
</institution-wrap>
Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Kyoto</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kangawa, Kenji" sort="Kangawa, Kenji" uniqKey="Kangawa K" first="Kenji" last="Kangawa">Kenji Kangawa</name>
<affiliation wicri:level="1"><nlm:aff id="Aff134"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Suita, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peters, Stefanie" sort="Peters, Stefanie" uniqKey="Peters S" first="Stefanie" last="Peters">Stefanie Peters</name>
<affiliation wicri:level="1"><nlm:aff id="Aff139"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmidt, Hannes" sort="Schmidt, Hannes" uniqKey="Schmidt H" first="Hannes" last="Schmidt">Hannes Schmidt</name>
<affiliation wicri:level="1"><nlm:aff id="Aff140"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1014 0849</institution-id>
<institution-id institution-id-type="GRID">grid.419491.0</institution-id>
<institution>Max-Delbrück-Centrum für Molekulare Medizin,</institution>
</institution-wrap>
Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Berlin</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff143"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Present address: Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Selin Kenet, B" sort="Selin Kenet, B" uniqKey="Selin Kenet B" first="B." last="Selin Kenet">B. Selin Kenet</name>
<affiliation wicri:level="1"><nlm:aff id="Aff139"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
<affiliation><nlm:aff id="Aff141">Present address: Institut für Zellbiologie des Nervensystems, München, TU Germany</nlm:aff>
<wicri:noCountry code="subfield">TU Germany</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Nies, Sarah Helena" sort="Nies, Sarah Helena" uniqKey="Nies S" first="Sarah Helena" last="Nies">Sarah Helena Nies</name>
<affiliation wicri:level="1"><nlm:aff id="Aff139"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Frank, Katharina" sort="Frank, Katharina" uniqKey="Frank K" first="Katharina" last="Frank">Katharina Frank</name>
<affiliation wicri:level="1"><nlm:aff id="Aff140"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1014 0849</institution-id>
<institution-id institution-id-type="GRID">grid.419491.0</institution-id>
<institution>Max-Delbrück-Centrum für Molekulare Medizin,</institution>
</institution-wrap>
Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Berlin</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff142"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 973X</institution-id>
<institution-id institution-id-type="GRID">grid.5252.0</institution-id>
<institution>Present address: Institut für Immunologie, BioMedical Center, LMU,</institution>
</institution-wrap>
Planegg-Martinsried, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Planegg-Martinsried</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wen, Lai" sort="Wen, Lai" uniqKey="Wen L" first="Lai" last="Wen">Lai Wen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff139"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rathjen, Fritz G" sort="Rathjen, Fritz G" uniqKey="Rathjen F" first="Fritz G." last="Rathjen">Fritz G. Rathjen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff140"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1014 0849</institution-id>
<institution-id institution-id-type="GRID">grid.419491.0</institution-id>
<institution>Max-Delbrück-Centrum für Molekulare Medizin,</institution>
</institution-wrap>
Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Feil, Robert" sort="Feil, Robert" uniqKey="Feil R" first="Robert" last="Feil">Robert Feil</name>
<affiliation wicri:level="1"><nlm:aff id="Aff139"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Petrova, Olga N" sort="Petrova, Olga N" uniqKey="Petrova O" first="Olga N." last="Petrova">Olga N. Petrova</name>
<affiliation wicri:level="1"><nlm:aff id="Aff144"><institution-wrap><institution-id institution-id-type="ISNI">0000000121581279</institution-id>
<institution-id institution-id-type="GRID">grid.10877.39</institution-id>
<institution>Laboratory for Optics and Biosciences,</institution>
<institution>Ecole Polytechnique,</institution>
</institution-wrap>
Palaiseau, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Palaiseau</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lamarre, Isabelle" sort="Lamarre, Isabelle" uniqKey="Lamarre I" first="Isabelle" last="Lamarre">Isabelle Lamarre</name>
<affiliation wicri:level="1"><nlm:aff id="Aff144"><institution-wrap><institution-id institution-id-type="ISNI">0000000121581279</institution-id>
<institution-id institution-id-type="GRID">grid.10877.39</institution-id>
<institution>Laboratory for Optics and Biosciences,</institution>
<institution>Ecole Polytechnique,</institution>
</institution-wrap>
Palaiseau, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Palaiseau</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Negrerie, Michel" sort="Negrerie, Michel" uniqKey="Negrerie M" first="Michel" last="Négrerie">Michel Négrerie</name>
<affiliation wicri:level="1"><nlm:aff id="Aff144"><institution-wrap><institution-id institution-id-type="ISNI">0000000121581279</institution-id>
<institution-id institution-id-type="GRID">grid.10877.39</institution-id>
<institution>Laboratory for Optics and Biosciences,</institution>
<institution>Ecole Polytechnique,</institution>
</institution-wrap>
Palaiseau, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Palaiseau</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Robinson, Jerid W" sort="Robinson, Jerid W" uniqKey="Robinson J" first="Jerid W." last="Robinson">Jerid W. Robinson</name>
<affiliation wicri:level="2"><nlm:aff id="Aff145"><institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Biochemistry, Molecular Biology, and Biophysics,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, MN USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Egbert, Jeremy R" sort="Egbert, Jeremy R" uniqKey="Egbert J" first="Jeremy R." last="Egbert">Jeremy R. Egbert</name>
<affiliation wicri:level="2"><nlm:aff id="Aff146"><institution-wrap><institution-id institution-id-type="ISNI">0000000419370394</institution-id>
<institution-id institution-id-type="GRID">grid.208078.5</institution-id>
<institution>Department of Cell Biology,</institution>
<institution>University of Connecticut Health Center,</institution>
</institution-wrap>
Farmington, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Farmington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Davydova, Julia" sort="Davydova, Julia" uniqKey="Davydova J" first="Julia" last="Davydova">Julia Davydova</name>
<affiliation wicri:level="2"><nlm:aff id="Aff147"><institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Surgery,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, MN USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jaffe, Laurinda A" sort="Jaffe, Laurinda A" uniqKey="Jaffe L" first="Laurinda A." last="Jaffe">Laurinda A. Jaffe</name>
<affiliation wicri:level="2"><nlm:aff id="Aff146"><institution-wrap><institution-id institution-id-type="ISNI">0000000419370394</institution-id>
<institution-id institution-id-type="GRID">grid.208078.5</institution-id>
<institution>Department of Cell Biology,</institution>
<institution>University of Connecticut Health Center,</institution>
</institution-wrap>
Farmington, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Farmington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Potter, Lincoln R" sort="Potter, Lincoln R" uniqKey="Potter L" first="Lincoln R." last="Potter">Lincoln R. Potter</name>
<affiliation wicri:level="2"><nlm:aff id="Aff145"><institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Biochemistry, Molecular Biology, and Biophysics,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, MN USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Minneapolis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff148"><institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, MN USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Robinson, Jerid W" sort="Robinson, Jerid W" uniqKey="Robinson J" first="Jerid W." last="Robinson">Jerid W. Robinson</name>
<affiliation wicri:level="2"><nlm:aff id="Aff149"><institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Biochemistry, Molecular Biology, and Biophysics,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, MN USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Blixt, Nicholas" sort="Blixt, Nicholas" uniqKey="Blixt N" first="Nicholas" last="Blixt">Nicholas Blixt</name>
<affiliation wicri:level="2"><nlm:aff id="Aff150"><institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Developmental and Surgical Sciences,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, MN USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Shuhaibar, Leia C" sort="Shuhaibar, Leia C" uniqKey="Shuhaibar L" first="Leia C." last="Shuhaibar">Leia C. Shuhaibar</name>
<affiliation wicri:level="2"><nlm:aff id="Aff151"><institution-wrap><institution-id institution-id-type="ISNI">0000000419370394</institution-id>
<institution-id institution-id-type="GRID">grid.208078.5</institution-id>
<institution>Department of Cell Biology,</institution>
<institution>University of Connecticut Health Center,</institution>
</institution-wrap>
Farmington, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Farmington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Warren, Gordon L" sort="Warren, Gordon L" uniqKey="Warren G" first="Gordon L." last="Warren">Gordon L. Warren</name>
<affiliation wicri:level="2"><nlm:aff id="Aff152"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7400</institution-id>
<institution-id institution-id-type="GRID">grid.256304.6</institution-id>
<institution>Department of Physical Therapy,</institution>
<institution>Georgia State University,</institution>
</institution-wrap>
Atlanta, GA USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
<wicri:cityArea>Atlanta</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mansky, Kim C" sort="Mansky, Kim C" uniqKey="Mansky K" first="Kim C." last="Mansky">Kim C. Mansky</name>
<affiliation wicri:level="2"><nlm:aff id="Aff150"><institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Developmental and Surgical Sciences,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, MN USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jaffe, Laurinda A" sort="Jaffe, Laurinda A" uniqKey="Jaffe L" first="Laurinda A." last="Jaffe">Laurinda A. Jaffe</name>
<affiliation wicri:level="2"><nlm:aff id="Aff151"><institution-wrap><institution-id institution-id-type="ISNI">0000000419370394</institution-id>
<institution-id institution-id-type="GRID">grid.208078.5</institution-id>
<institution>Department of Cell Biology,</institution>
<institution>University of Connecticut Health Center,</institution>
</institution-wrap>
Farmington, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Farmington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Potter, Lincoln R" sort="Potter, Lincoln R" uniqKey="Potter L" first="Lincoln R." last="Potter">Lincoln R. Potter</name>
<affiliation wicri:level="2"><nlm:aff id="Aff149"><institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Biochemistry, Molecular Biology, and Biophysics,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, MN USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Minneapolis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff153"><institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, MN USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Romoli, Simone" sort="Romoli, Simone" uniqKey="Romoli S" first="Simone" last="Romoli">Simone Romoli</name>
<affiliation wicri:level="1"><nlm:aff id="Aff154"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Cardiovascular Research II, Therapeutic Research Group, Drug Discovery, Bayer AG,</institution>
</institution-wrap>
Wuppertal, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Wuppertal</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bauch, Tobias" sort="Bauch, Tobias" uniqKey="Bauch T" first="Tobias" last="Bauch">Tobias Bauch</name>
<affiliation wicri:level="1"><nlm:aff id="Aff154"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Cardiovascular Research II, Therapeutic Research Group, Drug Discovery, Bayer AG,</institution>
</institution-wrap>
Wuppertal, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Wuppertal</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Drobner, Karoline" sort="Drobner, Karoline" uniqKey="Drobner K" first="Karoline" last="Dröbner">Karoline Dröbner</name>
<affiliation wicri:level="1"><nlm:aff id="Aff154"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Cardiovascular Research II, Therapeutic Research Group, Drug Discovery, Bayer AG,</institution>
</institution-wrap>
Wuppertal, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Wuppertal</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eitner, Frank" sort="Eitner, Frank" uniqKey="Eitner F" first="Frank" last="Eitner">Frank Eitner</name>
<affiliation wicri:level="1"><nlm:aff id="Aff154"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Cardiovascular Research II, Therapeutic Research Group, Drug Discovery, Bayer AG,</institution>
</institution-wrap>
Wuppertal, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Wuppertal</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ruppert, Mihaly" sort="Ruppert, Mihaly" uniqKey="Ruppert M" first="Mihály" last="Ruppert">Mihály Ruppert</name>
<affiliation wicri:level="1"><nlm:aff id="Aff155"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 4373</institution-id>
<institution-id institution-id-type="GRID">grid.7700.0</institution-id>
<institution>Department of Cardiac Surgery,</institution>
<institution>University of Heidelberg,</institution>
</institution-wrap>
Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Heidelberg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff156"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0942 9821</institution-id>
<institution-id institution-id-type="GRID">grid.11804.3c</institution-id>
<institution>Heart and Vascular Center,</institution>
<institution>Semmelweis University,</institution>
</institution-wrap>
Budapest, Hungary</nlm:aff>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea>Budapest</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Radovits, Tamas" sort="Radovits, Tamas" uniqKey="Radovits T" first="Tamás" last="Radovits">Tamás Radovits</name>
<affiliation wicri:level="1"><nlm:aff id="Aff156"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0942 9821</institution-id>
<institution-id institution-id-type="GRID">grid.11804.3c</institution-id>
<institution>Heart and Vascular Center,</institution>
<institution>Semmelweis University,</institution>
</institution-wrap>
Budapest, Hungary</nlm:aff>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea>Budapest</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Korkmaz Icoz, Sevil" sort="Korkmaz Icoz, Sevil" uniqKey="Korkmaz Icoz S" first="Sevil" last="Korkmaz-Icöz">Sevil Korkmaz-Icöz</name>
<affiliation wicri:level="1"><nlm:aff id="Aff155"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 4373</institution-id>
<institution-id institution-id-type="GRID">grid.7700.0</institution-id>
<institution>Department of Cardiac Surgery,</institution>
<institution>University of Heidelberg,</institution>
</institution-wrap>
Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Li, Shiliang" sort="Li, Shiliang" uniqKey="Li S" first="Shiliang" last="Li">Shiliang Li</name>
<affiliation wicri:level="1"><nlm:aff id="Aff155"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 4373</institution-id>
<institution-id institution-id-type="GRID">grid.7700.0</institution-id>
<institution>Department of Cardiac Surgery,</institution>
<institution>University of Heidelberg,</institution>
</institution-wrap>
Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heged S, Peter" sort="Heged S, Peter" uniqKey="Heged S P" first="Péter" last="Heged S">Péter Heged S</name>
<affiliation wicri:level="1"><nlm:aff id="Aff155"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 4373</institution-id>
<institution-id institution-id-type="GRID">grid.7700.0</institution-id>
<institution>Department of Cardiac Surgery,</institution>
<institution>University of Heidelberg,</institution>
</institution-wrap>
Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Loganathan, Sivakanan" sort="Loganathan, Sivakanan" uniqKey="Loganathan S" first="Sivakanan" last="Loganathan">Sivakanan Loganathan</name>
<affiliation wicri:level="1"><nlm:aff id="Aff155"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 4373</institution-id>
<institution-id institution-id-type="GRID">grid.7700.0</institution-id>
<institution>Department of Cardiac Surgery,</institution>
<institution>University of Heidelberg,</institution>
</institution-wrap>
Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nemeth, Balazs Tamas" sort="Nemeth, Balazs Tamas" uniqKey="Nemeth B" first="Balázs Tamás" last="Németh">Balázs Tamás Németh</name>
<affiliation wicri:level="1"><nlm:aff id="Aff156"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0942 9821</institution-id>
<institution-id institution-id-type="GRID">grid.11804.3c</institution-id>
<institution>Heart and Vascular Center,</institution>
<institution>Semmelweis University,</institution>
</institution-wrap>
Budapest, Hungary</nlm:aff>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea>Budapest</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Olah, Attila" sort="Olah, Attila" uniqKey="Olah A" first="Attila" last="Oláh">Attila Oláh</name>
<affiliation wicri:level="1"><nlm:aff id="Aff156"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0942 9821</institution-id>
<institution-id institution-id-type="GRID">grid.11804.3c</institution-id>
<institution>Heart and Vascular Center,</institution>
<institution>Semmelweis University,</institution>
</institution-wrap>
Budapest, Hungary</nlm:aff>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea>Budapest</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Matyas, Csaba" sort="Matyas, Csaba" uniqKey="Matyas C" first="Csaba" last="Mátyás">Csaba Mátyás</name>
<affiliation wicri:level="1"><nlm:aff id="Aff156"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0942 9821</institution-id>
<institution-id institution-id-type="GRID">grid.11804.3c</institution-id>
<institution>Heart and Vascular Center,</institution>
<institution>Semmelweis University,</institution>
</institution-wrap>
Budapest, Hungary</nlm:aff>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea>Budapest</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Benke, Kalman" sort="Benke, Kalman" uniqKey="Benke K" first="Kálmán" last="Benke">Kálmán Benke</name>
<affiliation wicri:level="1"><nlm:aff id="Aff156"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0942 9821</institution-id>
<institution-id institution-id-type="GRID">grid.11804.3c</institution-id>
<institution>Heart and Vascular Center,</institution>
<institution>Semmelweis University,</institution>
</institution-wrap>
Budapest, Hungary</nlm:aff>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea>Budapest</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Merkely, Bela" sort="Merkely, Bela" uniqKey="Merkely B" first="Béla" last="Merkely">Béla Merkely</name>
<affiliation wicri:level="1"><nlm:aff id="Aff156"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0942 9821</institution-id>
<institution-id institution-id-type="GRID">grid.11804.3c</institution-id>
<institution>Heart and Vascular Center,</institution>
<institution>Semmelweis University,</institution>
</institution-wrap>
Budapest, Hungary</nlm:aff>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea>Budapest</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Karck, Matthias" sort="Karck, Matthias" uniqKey="Karck M" first="Matthias" last="Karck">Matthias Karck</name>
<affiliation wicri:level="1"><nlm:aff id="Aff155"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 4373</institution-id>
<institution-id institution-id-type="GRID">grid.7700.0</institution-id>
<institution>Department of Cardiac Surgery,</institution>
<institution>University of Heidelberg,</institution>
</institution-wrap>
Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Szab, Gabor" sort="Szab, Gabor" uniqKey="Szab G" first="Gábor" last="Szab">Gábor Szab</name>
<affiliation wicri:level="1"><nlm:aff id="Aff155"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 4373</institution-id>
<institution-id institution-id-type="GRID">grid.7700.0</institution-id>
<institution>Department of Cardiac Surgery,</institution>
<institution>University of Heidelberg,</institution>
</institution-wrap>
Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Scheib, Ulrike" sort="Scheib, Ulrike" uniqKey="Scheib U" first="Ulrike" last="Scheib">Ulrike Scheib</name>
<affiliation wicri:level="1"><nlm:aff id="Aff157">Humboldt Universität zu Berlin, Institute for Biology, Experimental Biophysics, Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Humboldt Universität zu Berlin, Institute for Biology, Experimental Biophysics, Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Broser, Matthias" sort="Broser, Matthias" uniqKey="Broser M" first="Matthias" last="Broser">Matthias Broser</name>
<affiliation wicri:level="1"><nlm:aff id="Aff157">Humboldt Universität zu Berlin, Institute for Biology, Experimental Biophysics, Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Humboldt Universität zu Berlin, Institute for Biology, Experimental Biophysics, Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mukherjee, Shatanik" sort="Mukherjee, Shatanik" uniqKey="Mukherjee S" first="Shatanik" last="Mukherjee">Shatanik Mukherjee</name>
<affiliation wicri:level="1"><nlm:aff id="Aff157">Humboldt Universität zu Berlin, Institute for Biology, Experimental Biophysics, Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Humboldt Universität zu Berlin, Institute for Biology, Experimental Biophysics, Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stehfest, Katja" sort="Stehfest, Katja" uniqKey="Stehfest K" first="Katja" last="Stehfest">Katja Stehfest</name>
<affiliation wicri:level="1"><nlm:aff id="Aff157">Humboldt Universität zu Berlin, Institute for Biology, Experimental Biophysics, Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Humboldt Universität zu Berlin, Institute for Biology, Experimental Biophysics, Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gee, Christine E" sort="Gee, Christine E" uniqKey="Gee C" first="Christine E." last="Gee">Christine E. Gee</name>
<affiliation wicri:level="1"><nlm:aff id="Aff158">University Medical Center Hamburg-Eppendorf, Center for Molecular Neurobiology Hamburg, Institute for Synaptic Physiology, Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University Medical Center Hamburg-Eppendorf, Center for Molecular Neurobiology Hamburg, Institute for Synaptic Physiology, Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Korschen, Heinz G" sort="Korschen, Heinz G" uniqKey="Korschen H" first="Heinz G." last="Körschen">Heinz G. Körschen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff159"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0550 9586</institution-id>
<institution-id institution-id-type="GRID">grid.438114.b</institution-id>
<institution>Center of Advanced European Studies and Research (caesar) Bonn, Department: Molecular Sensory Systems,</institution>
</institution-wrap>
Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Bonn</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Oertner, Thomas G" sort="Oertner, Thomas G" uniqKey="Oertner T" first="Thomas G." last="Oertner">Thomas G. Oertner</name>
<affiliation wicri:level="1"><nlm:aff id="Aff158">University Medical Center Hamburg-Eppendorf, Center for Molecular Neurobiology Hamburg, Institute for Synaptic Physiology, Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University Medical Center Hamburg-Eppendorf, Center for Molecular Neurobiology Hamburg, Institute for Synaptic Physiology, Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hegemann, Peter" sort="Hegemann, Peter" uniqKey="Hegemann P" first="Peter" last="Hegemann">Peter Hegemann</name>
<affiliation wicri:level="1"><nlm:aff id="Aff157">Humboldt Universität zu Berlin, Institute for Biology, Experimental Biophysics, Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Humboldt Universität zu Berlin, Institute for Biology, Experimental Biophysics, Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmidt, Hannes" sort="Schmidt, Hannes" uniqKey="Schmidt H" first="Hannes" last="Schmidt">Hannes Schmidt</name>
<affiliation wicri:level="1"><nlm:aff id="Aff160"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfaculty Institute of Biochemistry,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff161"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1014 0849</institution-id>
<institution-id institution-id-type="GRID">grid.419491.0</institution-id>
<institution>Max Delbrück Center for Molecular Medicine in the Helmholtz Association,</institution>
</institution-wrap>
Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dickey, Deborah M" sort="Dickey, Deborah M" uniqKey="Dickey D" first="Deborah M." last="Dickey">Deborah M. Dickey</name>
<affiliation><nlm:aff id="Aff162"><institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Biochemistry,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, Minnesota USA</nlm:aff>
<wicri:noCountry code="subfield">Minnesota USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Dumoulin, Alexandre" sort="Dumoulin, Alexandre" uniqKey="Dumoulin A" first="Alexandre" last="Dumoulin">Alexandre Dumoulin</name>
<affiliation wicri:level="1"><nlm:aff id="Aff161"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1014 0849</institution-id>
<institution-id institution-id-type="GRID">grid.419491.0</institution-id>
<institution>Max Delbrück Center for Molecular Medicine in the Helmholtz Association,</institution>
</institution-wrap>
Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kuhn, Ralf" sort="Kuhn, Ralf" uniqKey="Kuhn R" first="Ralf" last="Kühn">Ralf Kühn</name>
<affiliation wicri:level="1"><nlm:aff id="Aff161"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1014 0849</institution-id>
<institution-id institution-id-type="GRID">grid.419491.0</institution-id>
<institution>Max Delbrück Center for Molecular Medicine in the Helmholtz Association,</institution>
</institution-wrap>
Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jaffe, Laurinda" sort="Jaffe, Laurinda" uniqKey="Jaffe L" first="Laurinda" last="Jaffe">Laurinda Jaffe</name>
<affiliation><nlm:aff id="Aff163"><institution-wrap><institution-id institution-id-type="ISNI">0000000419370394</institution-id>
<institution-id institution-id-type="GRID">grid.208078.5</institution-id>
<institution>Department of Cell Biology,</institution>
<institution>University of Connecticut Health Center,</institution>
</institution-wrap>
Farmington, Connecticut USA</nlm:aff>
<wicri:noCountry code="subfield">Connecticut USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Potter, Lincoln R" sort="Potter, Lincoln R" uniqKey="Potter L" first="Lincoln R." last="Potter">Lincoln R. Potter</name>
<affiliation><nlm:aff id="Aff162"><institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Biochemistry,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, Minnesota USA</nlm:aff>
<wicri:noCountry code="subfield">Minnesota USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Rathjen, Fritz G" sort="Rathjen, Fritz G" uniqKey="Rathjen F" first="Fritz G." last="Rathjen">Fritz G. Rathjen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff161"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1014 0849</institution-id>
<institution-id institution-id-type="GRID">grid.419491.0</institution-id>
<institution>Max Delbrück Center for Molecular Medicine in the Helmholtz Association,</institution>
</institution-wrap>
Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schobesberger, Sophie" sort="Schobesberger, Sophie" uniqKey="Schobesberger S" first="Sophie" last="Schobesberger">Sophie Schobesberger</name>
<affiliation wicri:level="1"><nlm:aff id="Aff164"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Institute of Experimental Cardiovascular Research,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>20246 Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wright, Peter" sort="Wright, Peter" uniqKey="Wright P" first="Peter" last="Wright">Peter Wright</name>
<affiliation><nlm:aff id="Aff165"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2113 8111</institution-id>
<institution-id institution-id-type="GRID">grid.7445.2</institution-id>
<institution>Department of Myocardial Function, Imperial College London, Hammersmith Hospital,</institution>
</institution-wrap>
W12 0NN, London, England UK</nlm:aff>
<wicri:noCountry code="subfield">England UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Poulet, Claire" sort="Poulet, Claire" uniqKey="Poulet C" first="Claire" last="Poulet">Claire Poulet</name>
<affiliation><nlm:aff id="Aff165"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2113 8111</institution-id>
<institution-id institution-id-type="GRID">grid.7445.2</institution-id>
<institution>Department of Myocardial Function, Imperial College London, Hammersmith Hospital,</institution>
</institution-wrap>
W12 0NN, London, England UK</nlm:aff>
<wicri:noCountry code="subfield">England UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mansfield, Catherine" sort="Mansfield, Catherine" uniqKey="Mansfield C" first="Catherine" last="Mansfield">Catherine Mansfield</name>
<affiliation><nlm:aff id="Aff165"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2113 8111</institution-id>
<institution-id institution-id-type="GRID">grid.7445.2</institution-id>
<institution>Department of Myocardial Function, Imperial College London, Hammersmith Hospital,</institution>
</institution-wrap>
W12 0NN, London, England UK</nlm:aff>
<wicri:noCountry code="subfield">England UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Friebe, Andreas" sort="Friebe, Andreas" uniqKey="Friebe A" first="Andreas" last="Friebe">Andreas Friebe</name>
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<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Institute of Physiology,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
97070 Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>97070 Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Harding, Sian E" sort="Harding, Sian E" uniqKey="Harding S" first="Sian E." last="Harding">Sian E. Harding</name>
<affiliation><nlm:aff id="Aff165"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2113 8111</institution-id>
<institution-id institution-id-type="GRID">grid.7445.2</institution-id>
<institution>Department of Myocardial Function, Imperial College London, Hammersmith Hospital,</institution>
</institution-wrap>
W12 0NN, London, England UK</nlm:aff>
<wicri:noCountry code="subfield">England UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Nikolaev, Viacheslav O" sort="Nikolaev, Viacheslav O" uniqKey="Nikolaev V" first="Viacheslav O." last="Nikolaev">Viacheslav O. Nikolaev</name>
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<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Institute of Experimental Cardiovascular Research,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
20246 Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>20246 Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gorelik, Julia" sort="Gorelik, Julia" uniqKey="Gorelik J" first="Julia" last="Gorelik">Julia Gorelik</name>
<affiliation><nlm:aff id="Aff165"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2113 8111</institution-id>
<institution-id institution-id-type="GRID">grid.7445.2</institution-id>
<institution>Department of Myocardial Function, Imperial College London, Hammersmith Hospital,</institution>
</institution-wrap>
W12 0NN, London, England UK</nlm:aff>
<wicri:noCountry code="subfield">England UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kollau, Alexander" sort="Kollau, Alexander" uniqKey="Kollau A" first="Alexander" last="Kollau">Alexander Kollau</name>
<affiliation wicri:level="1"><nlm:aff id="Aff167"><institution-wrap><institution-id institution-id-type="ISNI">0000000121539003</institution-id>
<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
A 8010 Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A 8010 Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Opelt, Marissa" sort="Opelt, Marissa" uniqKey="Opelt M" first="Marissa" last="Opelt">Marissa Opelt</name>
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<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
A 8010 Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A 8010 Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wolkart, Gerald" sort="Wolkart, Gerald" uniqKey="Wolkart G" first="Gerald" last="Wölkart">Gerald Wölkart</name>
<affiliation wicri:level="1"><nlm:aff id="Aff167"><institution-wrap><institution-id institution-id-type="ISNI">0000000121539003</institution-id>
<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
A 8010 Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A 8010 Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gorren, Antonius C F" sort="Gorren, Antonius C F" uniqKey="Gorren A" first="Antonius C. F." last="Gorren">Antonius C. F. Gorren</name>
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<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
A 8010 Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A 8010 Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Russwurm, Michael" sort="Russwurm, Michael" uniqKey="Russwurm M" first="Michael" last="Russwurm">Michael Russwurm</name>
<affiliation wicri:level="1"><nlm:aff id="Aff168"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>Ruhr University Bochum,</institution>
</institution-wrap>
D 44780 Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>D 44780 Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koesling, Doris" sort="Koesling, Doris" uniqKey="Koesling D" first="Doris" last="Koesling">Doris Koesling</name>
<affiliation wicri:level="1"><nlm:aff id="Aff168"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>Ruhr University Bochum,</institution>
</institution-wrap>
D 44780 Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>D 44780 Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schrammel, Astrid" sort="Schrammel, Astrid" uniqKey="Schrammel A" first="Astrid" last="Schrammel">Astrid Schrammel</name>
<affiliation wicri:level="1"><nlm:aff id="Aff167"><institution-wrap><institution-id institution-id-type="ISNI">0000000121539003</institution-id>
<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
A 8010 Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A 8010 Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mayer, Bernd" sort="Mayer, Bernd" uniqKey="Mayer B" first="Bernd" last="Mayer">Bernd Mayer</name>
<affiliation wicri:level="1"><nlm:aff id="Aff167"><institution-wrap><institution-id institution-id-type="ISNI">0000000121539003</institution-id>
<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
A 8010 Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A 8010 Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schwaerzer, Gerburg K" sort="Schwaerzer, Gerburg K" uniqKey="Schwaerzer G" first="Gerburg K." last="Schwaerzer">Gerburg K. Schwaerzer</name>
<affiliation wicri:level="1"><nlm:aff id="Aff169"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2181 7878</institution-id>
<institution-id institution-id-type="GRID">grid.47840.3f</institution-id>
<institution>Department of Medicine,</institution>
<institution>University of California San Diego,</institution>
</institution-wrap>
La Jolla, California, 92093 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>La Jolla, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Casteel, Darren E" sort="Casteel, Darren E" uniqKey="Casteel D" first="Darren E." last="Casteel">Darren E. Casteel</name>
<affiliation wicri:level="1"><nlm:aff id="Aff169"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2181 7878</institution-id>
<institution-id institution-id-type="GRID">grid.47840.3f</institution-id>
<institution>Department of Medicine,</institution>
<institution>University of California San Diego,</institution>
</institution-wrap>
La Jolla, California, 92093 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>La Jolla, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dalton, Nancy D" sort="Dalton, Nancy D" uniqKey="Dalton N" first="Nancy D." last="Dalton">Nancy D. Dalton</name>
<affiliation wicri:level="1"><nlm:aff id="Aff169"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2181 7878</institution-id>
<institution-id institution-id-type="GRID">grid.47840.3f</institution-id>
<institution>Department of Medicine,</institution>
<institution>University of California San Diego,</institution>
</institution-wrap>
La Jolla, California, 92093 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>La Jolla, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gu, Yusu" sort="Gu, Yusu" uniqKey="Gu Y" first="Yusu" last="Gu">Yusu Gu</name>
<affiliation wicri:level="1"><nlm:aff id="Aff169"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2181 7878</institution-id>
<institution-id institution-id-type="GRID">grid.47840.3f</institution-id>
<institution>Department of Medicine,</institution>
<institution>University of California San Diego,</institution>
</institution-wrap>
La Jolla, California, 92093 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>La Jolla, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhuang, Shunhui" sort="Zhuang, Shunhui" uniqKey="Zhuang S" first="Shunhui" last="Zhuang">Shunhui Zhuang</name>
<affiliation wicri:level="1"><nlm:aff id="Aff169"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2181 7878</institution-id>
<institution-id institution-id-type="GRID">grid.47840.3f</institution-id>
<institution>Department of Medicine,</institution>
<institution>University of California San Diego,</institution>
</institution-wrap>
La Jolla, California, 92093 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>La Jolla, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Milewicz, Dianna M" sort="Milewicz, Dianna M" uniqKey="Milewicz D" first="Dianna M." last="Milewicz">Dianna M. Milewicz</name>
<affiliation wicri:level="2"><nlm:aff id="Aff170"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9206 2401</institution-id>
<institution-id institution-id-type="GRID">grid.267308.8</institution-id>
<institution>Division of Medical Genetics and Cardiology, Department of Internal Medicine,</institution>
<institution>The University of Texas Health Science Center at Houston,</institution>
</institution-wrap>
Houston, Texas 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Peterson, Kirk L" sort="Peterson, Kirk L" uniqKey="Peterson K" first="Kirk L." last="Peterson">Kirk L. Peterson</name>
<affiliation wicri:level="2"><nlm:aff id="Aff170"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9206 2401</institution-id>
<institution-id institution-id-type="GRID">grid.267308.8</institution-id>
<institution>Division of Medical Genetics and Cardiology, Department of Internal Medicine,</institution>
<institution>The University of Texas Health Science Center at Houston,</institution>
</institution-wrap>
Houston, Texas 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Pilz, Renate" sort="Pilz, Renate" uniqKey="Pilz R" first="Renate" last="Pilz">Renate Pilz</name>
<affiliation wicri:level="1"><nlm:aff id="Aff169"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2181 7878</institution-id>
<institution-id institution-id-type="GRID">grid.47840.3f</institution-id>
<institution>Department of Medicine,</institution>
<institution>University of California San Diego,</institution>
</institution-wrap>
La Jolla, California, 92093 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>La Jolla, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schwiering, Fabian" sort="Schwiering, Fabian" uniqKey="Schwiering F" first="Fabian" last="Schwiering">Fabian Schwiering</name>
<affiliation wicri:level="1"><nlm:aff id="Aff171"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aue, Annemarie" sort="Aue, Annemarie" uniqKey="Aue A" first="Annemarie" last="Aue">Annemarie Aue</name>
<affiliation wicri:level="1"><nlm:aff id="Aff171"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Groneberg, Dieter" sort="Groneberg, Dieter" uniqKey="Groneberg D" first="Dieter" last="Groneberg">Dieter Groneberg</name>
<affiliation wicri:level="1"><nlm:aff id="Aff171"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Friebe, Andreas" sort="Friebe, Andreas" uniqKey="Friebe A" first="Andreas" last="Friebe">Andreas Friebe</name>
<affiliation wicri:level="1"><nlm:aff id="Aff171"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Argyriou, Aikaterini I" sort="Argyriou, Aikaterini I" uniqKey="Argyriou A" first="Aikaterini I." last="Argyriou">Aikaterini I. Argyriou</name>
<affiliation wicri:level="1"><nlm:aff id="Aff172"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0576 5395</institution-id>
<institution-id institution-id-type="GRID">grid.11047.33</institution-id>
<institution>Department of Pharmacy,</institution>
<institution>University of Patras,</institution>
</institution-wrap>
GR-26504 Patras, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>GR-26504 Patras</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Makrynitsa, Garyfalia" sort="Makrynitsa, Garyfalia" uniqKey="Makrynitsa G" first="Garyfalia" last="Makrynitsa">Garyfalia Makrynitsa</name>
<affiliation wicri:level="1"><nlm:aff id="Aff172"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0576 5395</institution-id>
<institution-id institution-id-type="GRID">grid.11047.33</institution-id>
<institution>Department of Pharmacy,</institution>
<institution>University of Patras,</institution>
</institution-wrap>
GR-26504 Patras, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>GR-26504 Patras</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alexandropoulos, Ioannis I" sort="Alexandropoulos, Ioannis I" uniqKey="Alexandropoulos I" first="Ioannis I." last="Alexandropoulos">Ioannis I. Alexandropoulos</name>
<affiliation wicri:level="1"><nlm:aff id="Aff172"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0576 5395</institution-id>
<institution-id institution-id-type="GRID">grid.11047.33</institution-id>
<institution>Department of Pharmacy,</institution>
<institution>University of Patras,</institution>
</institution-wrap>
GR-26504 Patras, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>GR-26504 Patras</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stamopoulou, Andriana" sort="Stamopoulou, Andriana" uniqKey="Stamopoulou A" first="Andriana" last="Stamopoulou">Andriana Stamopoulou</name>
<affiliation wicri:level="1"><nlm:aff id="Aff172"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0576 5395</institution-id>
<institution-id institution-id-type="GRID">grid.11047.33</institution-id>
<institution>Department of Pharmacy,</institution>
<institution>University of Patras,</institution>
</institution-wrap>
GR-26504 Patras, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>GR-26504 Patras</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bantzi, Marina" sort="Bantzi, Marina" uniqKey="Bantzi M" first="Marina" last="Bantzi">Marina Bantzi</name>
<affiliation wicri:level="1"><nlm:aff id="Aff173"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2230 9752</institution-id>
<institution-id institution-id-type="GRID">grid.9647.c</institution-id>
<institution>Institute of Organic Chemistry,</institution>
<institution>Leipzig University,</institution>
</institution-wrap>
D-04103 Leipzig, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>D-04103 Leipzig</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Giannis, Athanassios" sort="Giannis, Athanassios" uniqKey="Giannis A" first="Athanassios" last="Giannis">Athanassios Giannis</name>
<affiliation wicri:level="1"><nlm:aff id="Aff173"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2230 9752</institution-id>
<institution-id institution-id-type="GRID">grid.9647.c</institution-id>
<institution>Institute of Organic Chemistry,</institution>
<institution>Leipzig University,</institution>
</institution-wrap>
D-04103 Leipzig, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>D-04103 Leipzig</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Topouzis, Stavros" sort="Topouzis, Stavros" uniqKey="Topouzis S" first="Stavros" last="Topouzis">Stavros Topouzis</name>
<affiliation wicri:level="1"><nlm:aff id="Aff172"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0576 5395</institution-id>
<institution-id institution-id-type="GRID">grid.11047.33</institution-id>
<institution>Department of Pharmacy,</institution>
<institution>University of Patras,</institution>
</institution-wrap>
GR-26504 Patras, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>GR-26504 Patras</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Papapetropoulos, Andreas" sort="Papapetropoulos, Andreas" uniqKey="Papapetropoulos A" first="Andreas" last="Papapetropoulos">Andreas Papapetropoulos</name>
<affiliation wicri:level="1"><nlm:aff id="Aff172"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0576 5395</institution-id>
<institution-id institution-id-type="GRID">grid.11047.33</institution-id>
<institution>Department of Pharmacy,</institution>
<institution>University of Patras,</institution>
</institution-wrap>
GR-26504 Patras, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>GR-26504 Patras</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff174"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2155 0800</institution-id>
<institution-id institution-id-type="GRID">grid.5216.0</institution-id>
<institution>School of Health Sciences, Faculty of Pharmacy,</institution>
<institution>University of Athens,</institution>
</institution-wrap>
GR-15 771 Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>GR-15 771 Athens</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Spyroulias, Georgios A" sort="Spyroulias, Georgios A" uniqKey="Spyroulias G" first="Georgios A." last="Spyroulias">Georgios A. Spyroulias</name>
<affiliation wicri:level="1"><nlm:aff id="Aff172"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0576 5395</institution-id>
<institution-id institution-id-type="GRID">grid.11047.33</institution-id>
<institution>Department of Pharmacy,</institution>
<institution>University of Patras,</institution>
</institution-wrap>
GR-26504 Patras, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>GR-26504 Patras</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stuehr, Dennis J" sort="Stuehr, Dennis J" uniqKey="Stuehr D" first="Dennis J." last="Stuehr">Dennis J. Stuehr</name>
<affiliation wicri:level="2"><nlm:aff id="Aff175"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0675 4725</institution-id>
<institution-id institution-id-type="GRID">grid.239578.2</institution-id>
<institution>Department of Pathobiology, Lerner Research Institute, Cleveland Clinic,</institution>
</institution-wrap>
Cleveland, Ohio 44195 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ghosh, Arnab" sort="Ghosh, Arnab" uniqKey="Ghosh A" first="Arnab" last="Ghosh">Arnab Ghosh</name>
<affiliation wicri:level="2"><nlm:aff id="Aff175"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0675 4725</institution-id>
<institution-id institution-id-type="GRID">grid.239578.2</institution-id>
<institution>Department of Pathobiology, Lerner Research Institute, Cleveland Clinic,</institution>
</institution-wrap>
Cleveland, Ohio 44195 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dai, Yue" sort="Dai, Yue" uniqKey="Dai Y" first="Yue" last="Dai">Yue Dai</name>
<affiliation wicri:level="2"><nlm:aff id="Aff175"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0675 4725</institution-id>
<institution-id institution-id-type="GRID">grid.239578.2</institution-id>
<institution>Department of Pathobiology, Lerner Research Institute, Cleveland Clinic,</institution>
</institution-wrap>
Cleveland, Ohio 44195 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Misra, Saurav" sort="Misra, Saurav" uniqKey="Misra S" first="Saurav" last="Misra">Saurav Misra</name>
<affiliation wicri:level="2"><nlm:aff id="Aff176"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0737 1259</institution-id>
<institution-id institution-id-type="GRID">grid.36567.31</institution-id>
<institution>Kansas State University,</institution>
</institution-wrap>
Manhattan, Kansas 66506 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kansas</region>
</placeName>
<wicri:cityArea>Manhattan</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tchernychev, Boris" sort="Tchernychev, Boris" uniqKey="Tchernychev B" first="Boris" last="Tchernychev">Boris Tchernychev</name>
<affiliation wicri:level="2"><nlm:aff id="Aff177"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jung, Joon" sort="Jung, Joon" uniqKey="Jung J" first="Joon" last="Jung">Joon Jung</name>
<affiliation wicri:level="2"><nlm:aff id="Aff177"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Liu, Guang" sort="Liu, Guang" uniqKey="Liu G" first="Guang" last="Liu">Guang Liu</name>
<affiliation wicri:level="2"><nlm:aff id="Aff177"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Silos Santiago, Inmaculada" sort="Silos Santiago, Inmaculada" uniqKey="Silos Santiago I" first="Inmaculada" last="Silos-Santiago">Inmaculada Silos-Santiago</name>
<affiliation wicri:level="2"><nlm:aff id="Aff178">Decibel Therapeutics, Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Decibel Therapeutics, Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hannig, Gerhard" sort="Hannig, Gerhard" uniqKey="Hannig G" first="Gerhard" last="Hannig">Gerhard Hannig</name>
<affiliation wicri:level="2"><nlm:aff id="Aff177"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dao, Vu Thao Vi" sort="Dao, Vu Thao Vi" uniqKey="Dao V" first="Vu Thao-Vi" last="Dao">Vu Thao-Vi Dao</name>
<affiliation wicri:level="1"><nlm:aff id="Aff179"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0481 6099</institution-id>
<institution-id institution-id-type="GRID">grid.5012.6</institution-id>
<institution>Department for Pharmacology and Personalized Medicine, CARIM, FHML,</institution>
<institution>Maastricht University,</institution>
</institution-wrap>
Maastricht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Maastricht</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff180"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1941 7111</institution-id>
<institution-id institution-id-type="GRID">grid.5802.f</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>Johannes Gutenberg University,</institution>
</institution-wrap>
Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Mainz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Deile, Martin" sort="Deile, Martin" uniqKey="Deile M" first="Martin" last="Deile">Martin Deile</name>
<affiliation wicri:level="1"><nlm:aff id="Aff181">Asklepios-Klinik Radeberg, Dresden, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Asklepios-Klinik Radeberg, Dresden</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nedvetsky, Pavel I" sort="Nedvetsky, Pavel I" uniqKey="Nedvetsky P" first="Pavel I." last="Nedvetsky">Pavel I. Nedvetsky</name>
<affiliation wicri:level="1"><nlm:aff id="Aff182"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0668 7884</institution-id>
<institution-id institution-id-type="GRID">grid.5596.f</institution-id>
<institution>Vesalius Research Center,</institution>
<institution>Katholieke Universiteit Leuven,</institution>
</institution-wrap>
Leuven, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Leuven</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guldner, Andreas" sort="Guldner, Andreas" uniqKey="Guldner A" first="Andreas" last="Güldner">Andreas Güldner</name>
<affiliation wicri:level="1"><nlm:aff id="Aff183"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2111 7257</institution-id>
<institution-id institution-id-type="GRID">grid.4488.0</institution-id>
<institution>Residency Anaesthesiology, Department of Anaesthesiology und Critical Care Medicine,</institution>
<institution>Technische Universität,</institution>
</institution-wrap>
Dresden, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dresden</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ibarra Alvarado, Cesar" sort="Ibarra Alvarado, Cesar" uniqKey="Ibarra Alvarado C" first="César" last="Ibarra-Alvarado">César Ibarra-Alvarado</name>
<affiliation wicri:level="1"><nlm:aff id="Aff184"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2207 2097</institution-id>
<institution-id institution-id-type="GRID">grid.412861.8</institution-id>
<institution>Facultad de Química, Universidad Autónoma de Querétaro,</institution>
</institution-wrap>
Santiago de Querétaro, Mexico</nlm:aff>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>Santiago de Querétaro</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Godecke, Axel" sort="Godecke, Axel" uniqKey="Godecke A" first="Axel" last="Gödecke">Axel Gödecke</name>
<affiliation wicri:level="1"><nlm:aff id="Aff185"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2176 9917</institution-id>
<institution-id institution-id-type="GRID">grid.411327.2</institution-id>
<institution>Institut für Herz- und Kreislaufphysiologie Heinrich-Heine-Universität,</institution>
</institution-wrap>
Düsseldorf, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Düsseldorf</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmidt, Harald H H W" sort="Schmidt, Harald H H W" uniqKey="Schmidt H" first="Harald H. H. W." last="Schmidt">Harald H. H. W. Schmidt</name>
<affiliation wicri:level="1"><nlm:aff id="Aff179"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0481 6099</institution-id>
<institution-id institution-id-type="GRID">grid.5012.6</institution-id>
<institution>Department for Pharmacology and Personalized Medicine, CARIM, FHML,</institution>
<institution>Maastricht University,</institution>
</institution-wrap>
Maastricht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Maastricht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vachaviolos, Angelos" sort="Vachaviolos, Angelos" uniqKey="Vachaviolos A" first="Angelos" last="Vachaviolos">Angelos Vachaviolos</name>
<affiliation wicri:level="1"><nlm:aff id="Aff186"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gerling, Andrea" sort="Gerling, Andrea" uniqKey="Gerling A" first="Andrea" last="Gerling">Andrea Gerling</name>
<affiliation wicri:level="1"><nlm:aff id="Aff186"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thunemann, Martin" sort="Thunemann, Martin" uniqKey="Thunemann M" first="Martin" last="Thunemann">Martin Thunemann</name>
<affiliation wicri:level="1"><nlm:aff id="Aff186"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lutz, Stefan Z" sort="Lutz, Stefan Z" uniqKey="Lutz S" first="Stefan Z." last="Lutz">Stefan Z. Lutz</name>
<affiliation wicri:level="1"><nlm:aff id="Aff187"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="H Ring, Hans Ulrich" sort="H Ring, Hans Ulrich" uniqKey="H Ring H" first="Hans-Ulrich" last="H Ring">Hans-Ulrich H Ring</name>
<affiliation wicri:level="1"><nlm:aff id="Aff187"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kruger, Marcel A" sort="Kruger, Marcel A" uniqKey="Kruger M" first="Marcel A." last="Krüger">Marcel A. Krüger</name>
<affiliation wicri:level="1"><nlm:aff id="Aff188"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pichler, Bernd J" sort="Pichler, Bernd J" uniqKey="Pichler B" first="Bernd J." last="Pichler">Bernd J. Pichler</name>
<affiliation wicri:level="1"><nlm:aff id="Aff188"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Shipston, Michael J" sort="Shipston, Michael J" uniqKey="Shipston M" first="Michael J." last="Shipston">Michael J. Shipston</name>
<affiliation><nlm:aff id="Aff189"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7988</institution-id>
<institution-id institution-id-type="GRID">grid.4305.2</institution-id>
<institution>Centre for Integrative Physiology, School of Biomedical Science, Hugh Robson Building,</institution>
<institution>University of Edinburgh,</institution>
</institution-wrap>
Edinburgh, Scotland EH8 9XD UK</nlm:aff>
<wicri:noCountry code="subfield">Scotland EH8 9XD UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Feil, Susanne" sort="Feil, Susanne" uniqKey="Feil S" first="Susanne" last="Feil">Susanne Feil</name>
<affiliation wicri:level="1"><nlm:aff id="Aff186"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Feil, Robert" sort="Feil, Robert" uniqKey="Feil R" first="Robert" last="Feil">Robert Feil</name>
<affiliation wicri:level="1"><nlm:aff id="Aff186"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vandenwijngaert, Sara" sort="Vandenwijngaert, Sara" uniqKey="Vandenwijngaert S" first="Sara" last="Vandenwijngaert">Sara Vandenwijngaert</name>
<affiliation><nlm:aff id="Aff190"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School,</institution>
</institution-wrap>
Boston, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ledsky, Clara D" sort="Ledsky, Clara D" uniqKey="Ledsky C" first="Clara D." last="Ledsky">Clara D. Ledsky</name>
<affiliation><nlm:aff id="Aff190"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School,</institution>
</institution-wrap>
Boston, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Agha, Obiajulu" sort="Agha, Obiajulu" uniqKey="Agha O" first="Obiajulu" last="Agha">Obiajulu Agha</name>
<affiliation><nlm:aff id="Aff190"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School,</institution>
</institution-wrap>
Boston, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Hu, Dongjian" sort="Hu, Dongjian" uniqKey="Hu D" first="Dongjian" last="Hu">Dongjian Hu</name>
<affiliation><nlm:aff id="Aff191"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital and Harvard Medical School,</institution>
</institution-wrap>
Boston, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Domian, Ibrahim J" sort="Domian, Ibrahim J" uniqKey="Domian I" first="Ibrahim J." last="Domian">Ibrahim J. Domian</name>
<affiliation><nlm:aff id="Aff191"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital and Harvard Medical School,</institution>
</institution-wrap>
Boston, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff192"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Harvard Stem Cell Institute,</institution>
</institution-wrap>
Cambridge, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Buys, Emmanuel S" sort="Buys, Emmanuel S" uniqKey="Buys E" first="Emmanuel S." last="Buys">Emmanuel S. Buys</name>
<affiliation><nlm:aff id="Aff190"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School,</institution>
</institution-wrap>
Boston, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Newton Cheh, Christopher" sort="Newton Cheh, Christopher" uniqKey="Newton Cheh C" first="Christopher" last="Newton-Cheh">Christopher Newton-Cheh</name>
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<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital and Harvard Medical School,</institution>
</institution-wrap>
Boston, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff193"><institution-wrap><institution-id institution-id-type="GRID">grid.66859.34</institution-id>
<institution>Program in Medical and Population Genetics, Broad Institute,</institution>
</institution-wrap>
Cambridge, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff194"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School,</institution>
</institution-wrap>
Boston, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bloch, Donald B" sort="Bloch, Donald B" uniqKey="Bloch D" first="Donald B." last="Bloch">Donald B. Bloch</name>
<affiliation><nlm:aff id="Aff190"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School,</institution>
</institution-wrap>
Boston, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff195"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School,</institution>
</institution-wrap>
Boston, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Voussen, Barbara" sort="Voussen, Barbara" uniqKey="Voussen B" first="Barbara" last="Voussen">Barbara Voussen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff196"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Beck, Katharina" sort="Beck, Katharina" uniqKey="Beck K" first="Katharina" last="Beck">Katharina Beck</name>
<affiliation wicri:level="1"><nlm:aff id="Aff196"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mauro, Nadine" sort="Mauro, Nadine" uniqKey="Mauro N" first="Nadine" last="Mauro">Nadine Mauro</name>
<affiliation wicri:level="1"><nlm:aff id="Aff196"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Keppler, Jonas" sort="Keppler, Jonas" uniqKey="Keppler J" first="Jonas" last="Keppler">Jonas Keppler</name>
<affiliation wicri:level="1"><nlm:aff id="Aff196"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Friebe, Andreas" sort="Friebe, Andreas" uniqKey="Friebe A" first="Andreas" last="Friebe">Andreas Friebe</name>
<affiliation wicri:level="1"><nlm:aff id="Aff196"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ferreira, Wilson A" sort="Ferreira, Wilson A" uniqKey="Ferreira W" first="Wilson A." last="Ferreira">Wilson A. Ferreira</name>
<affiliation wicri:level="1"><nlm:aff id="Aff197"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0723 2494</institution-id>
<institution-id institution-id-type="GRID">grid.411087.b</institution-id>
<institution>Hematology Centre, School of Medical Sciences,</institution>
<institution>University of Campinas (UNICAMP),</institution>
</institution-wrap>
Sao Paolo, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Sao Paolo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chweih, Hanan" sort="Chweih, Hanan" uniqKey="Chweih H" first="Hanan" last="Chweih">Hanan Chweih</name>
<affiliation wicri:level="1"><nlm:aff id="Aff197"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0723 2494</institution-id>
<institution-id institution-id-type="GRID">grid.411087.b</institution-id>
<institution>Hematology Centre, School of Medical Sciences,</institution>
<institution>University of Campinas (UNICAMP),</institution>
</institution-wrap>
Sao Paolo, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Sao Paolo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brito, Pamela L" sort="Brito, Pamela L" uniqKey="Brito P" first="Pamela L." last="Brito">Pamela L. Brito</name>
<affiliation wicri:level="1"><nlm:aff id="Aff197"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0723 2494</institution-id>
<institution-id institution-id-type="GRID">grid.411087.b</institution-id>
<institution>Hematology Centre, School of Medical Sciences,</institution>
<institution>University of Campinas (UNICAMP),</institution>
</institution-wrap>
Sao Paolo, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Sao Paolo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Almeida, Camila B" sort="Almeida, Camila B" uniqKey="Almeida C" first="Camila B." last="Almeida">Camila B. Almeida</name>
<affiliation wicri:level="1"><nlm:aff id="Aff197"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0723 2494</institution-id>
<institution-id institution-id-type="GRID">grid.411087.b</institution-id>
<institution>Hematology Centre, School of Medical Sciences,</institution>
<institution>University of Campinas (UNICAMP),</institution>
</institution-wrap>
Sao Paolo, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Sao Paolo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Penteado, Carla F F" sort="Penteado, Carla F F" uniqKey="Penteado C" first="Carla F. F." last="Penteado">Carla F. F. Penteado</name>
<affiliation wicri:level="1"><nlm:aff id="Aff197"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0723 2494</institution-id>
<institution-id institution-id-type="GRID">grid.411087.b</institution-id>
<institution>Hematology Centre, School of Medical Sciences,</institution>
<institution>University of Campinas (UNICAMP),</institution>
</institution-wrap>
Sao Paolo, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Sao Paolo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Saad, Sara S O" sort="Saad, Sara S O" uniqKey="Saad S" first="Sara S. O." last="Saad">Sara S. O. Saad</name>
<affiliation wicri:level="1"><nlm:aff id="Aff197"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0723 2494</institution-id>
<institution-id institution-id-type="GRID">grid.411087.b</institution-id>
<institution>Hematology Centre, School of Medical Sciences,</institution>
<institution>University of Campinas (UNICAMP),</institution>
</institution-wrap>
Sao Paolo, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Sao Paolo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Costa, Fernando F" sort="Costa, Fernando F" uniqKey="Costa F" first="Fernando F." last="Costa">Fernando F. Costa</name>
<affiliation wicri:level="1"><nlm:aff id="Aff197"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0723 2494</institution-id>
<institution-id institution-id-type="GRID">grid.411087.b</institution-id>
<institution>Hematology Centre, School of Medical Sciences,</institution>
<institution>University of Campinas (UNICAMP),</institution>
</institution-wrap>
Sao Paolo, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Sao Paolo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Frenette, Paul S" sort="Frenette, Paul S" uniqKey="Frenette P" first="Paul S." last="Frenette">Paul S. Frenette</name>
<affiliation wicri:level="2"><nlm:aff id="Aff199"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2152 0791</institution-id>
<institution-id institution-id-type="GRID">grid.240283.f</institution-id>
<institution>Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine,</institution>
</institution-wrap>
Bronx, NY USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Bronx</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Brockschnieder, Damian" sort="Brockschnieder, Damian" uniqKey="Brockschnieder D" first="Damian" last="Brockschnieder">Damian Brockschnieder</name>
<affiliation wicri:level="1"><nlm:aff id="Aff198"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Bayer AG, Pharmaceuticals - Drug Discovery,</institution>
</institution-wrap>
Wuppertal, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Wuppertal</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stasch, Johannes Peter" sort="Stasch, Johannes Peter" uniqKey="Stasch J" first="Johannes-Peter" last="Stasch">Johannes-Peter Stasch</name>
<affiliation wicri:level="1"><nlm:aff id="Aff198"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Bayer AG, Pharmaceuticals - Drug Discovery,</institution>
</institution-wrap>
Wuppertal, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Wuppertal</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sandner, Peter" sort="Sandner, Peter" uniqKey="Sandner P" first="Peter" last="Sandner">Peter Sandner</name>
<affiliation wicri:level="1"><nlm:aff id="Aff198"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Bayer AG, Pharmaceuticals - Drug Discovery,</institution>
</institution-wrap>
Wuppertal, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Wuppertal</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Conran, Nicola" sort="Conran, Nicola" uniqKey="Conran N" first="Nicola" last="Conran">Nicola Conran</name>
<affiliation wicri:level="1"><nlm:aff id="Aff197"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0723 2494</institution-id>
<institution-id institution-id-type="GRID">grid.411087.b</institution-id>
<institution>Hematology Centre, School of Medical Sciences,</institution>
<institution>University of Campinas (UNICAMP),</institution>
</institution-wrap>
Sao Paolo, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Sao Paolo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zimmer, Daniel P" sort="Zimmer, Daniel P" uniqKey="Zimmer D" first="Daniel P." last="Zimmer">Daniel P. Zimmer</name>
<affiliation wicri:level="2"><nlm:aff id="Aff200"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tobin, Jenny" sort="Tobin, Jenny" uniqKey="Tobin J" first="Jenny" last="Tobin">Jenny Tobin</name>
<affiliation wicri:level="2"><nlm:aff id="Aff200"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Shea, Courtney" sort="Shea, Courtney" uniqKey="Shea C" first="Courtney" last="Shea">Courtney Shea</name>
<affiliation wicri:level="2"><nlm:aff id="Aff200"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sarno, Renee" sort="Sarno, Renee" uniqKey="Sarno R" first="Renee" last="Sarno">Renee Sarno</name>
<affiliation wicri:level="2"><nlm:aff id="Aff200"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Long, Kimberly" sort="Long, Kimberly" uniqKey="Long K" first="Kimberly" last="Long">Kimberly Long</name>
<affiliation wicri:level="2"><nlm:aff id="Aff200"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jacobson, Sarah" sort="Jacobson, Sarah" uniqKey="Jacobson S" first="Sarah" last="Jacobson">Sarah Jacobson</name>
<affiliation wicri:level="2"><nlm:aff id="Aff200"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tang, Kim" sort="Tang, Kim" uniqKey="Tang K" first="Kim" last="Tang">Kim Tang</name>
<affiliation wicri:level="2"><nlm:aff id="Aff200"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Germano, Peter" sort="Germano, Peter" uniqKey="Germano P" first="Peter" last="Germano">Peter Germano</name>
<affiliation wicri:level="2"><nlm:aff id="Aff200"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wakefield, James" sort="Wakefield, James" uniqKey="Wakefield J" first="James" last="Wakefield">James Wakefield</name>
<affiliation wicri:level="2"><nlm:aff id="Aff200"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Banijamali, Ali" sort="Banijamali, Ali" uniqKey="Banijamali A" first="Ali" last="Banijamali">Ali Banijamali</name>
<affiliation wicri:level="2"><nlm:aff id="Aff200"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Im, G Yoon Jamie" sort="Im, G Yoon Jamie" uniqKey="Im G" first="G-Yoon Jamie" last="Im">G-Yoon Jamie Im</name>
<affiliation wicri:level="2"><nlm:aff id="Aff200"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sheppeck, James E" sort="Sheppeck, James E" uniqKey="Sheppeck J" first="James E." last="Sheppeck">James E. Sheppeck</name>
<affiliation wicri:level="2"><nlm:aff id="Aff200"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Profy, Albert T" sort="Profy, Albert T" uniqKey="Profy A" first="Albert T." last="Profy">Albert T. Profy</name>
<affiliation wicri:level="2"><nlm:aff id="Aff200"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Todd Milne, G" sort="Todd Milne, G" uniqKey="Todd Milne G" first="G." last="Todd Milne">G. Todd Milne</name>
<affiliation wicri:level="2"><nlm:aff id="Aff200"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Currie, Mark G" sort="Currie, Mark G" uniqKey="Currie M" first="Mark G." last="Currie">Mark G. Currie</name>
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<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
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Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Masferrer, Jaime L" sort="Masferrer, Jaime L" uniqKey="Masferrer J" first="Jaime L." last="Masferrer">Jaime L. Masferrer</name>
<affiliation wicri:level="2"><nlm:aff id="Aff200"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
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Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
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<wicri:cityArea>Cambridge</wicri:cityArea>
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<series><title level="j">BMC Pharmacology & Toxicology</title>
<idno type="eISSN">2050-6511</idno>
<imprint><date when="2017">2017</date>
</imprint>
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<pmc article-type="abstract"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Pharmacol Toxicol</journal-id>
<journal-id journal-id-type="iso-abbrev">BMC Pharmacol Toxicol</journal-id>
<journal-title-group><journal-title>BMC Pharmacology & Toxicology</journal-title>
</journal-title-group>
<issn pub-type="epub">2050-6511</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">29035170</article-id>
<article-id pub-id-type="pmc">5667593</article-id>
<article-id pub-id-type="publisher-id">170</article-id>
<article-id pub-id-type="doi">10.1186/s40360-017-0170-5</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Meeting Abstracts</subject>
</subj-group>
</article-categories>
<title-group><article-title>Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications</article-title>
<subtitle>Bamberg, Germany. 23-25 June, 2017</subtitle>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Todd Milne</surname>
<given-names>G.</given-names>
</name>
<address><email>tmilne@ironwoodpharma.com</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><collab>on behalf of the Ironwood team</collab>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Sandner</surname>
<given-names>Peter</given-names>
</name>
<address><email>peter.sandner@bayer.com</email>
</address>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lincoln</surname>
<given-names>Kathleen A.</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Harrison</surname>
<given-names>Paul C.</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Hongxing</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Hong</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Clifford</surname>
<given-names>Holly</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Qian</surname>
<given-names>Hu Sheng</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wong</surname>
<given-names>Diane</given-names>
</name>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sarko</surname>
<given-names>Chris</given-names>
</name>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fryer</surname>
<given-names>Ryan</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Richman</surname>
<given-names>Jeremy</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Reinhart</surname>
<given-names>Glenn A.</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Boustany</surname>
<given-names>Carine M.</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Pullen</surname>
<given-names>Steven S.</given-names>
</name>
<address><email>steven.pullen@boehringer-ingelheim.com</email>
</address>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Andresen</surname>
<given-names>Henriette</given-names>
</name>
<address><email>henriette.andresen@studmed.uio.no</email>
</address>
<xref ref-type="aff" rid="Aff5">5</xref>
<xref ref-type="aff" rid="Aff6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Moltzau</surname>
<given-names>Lise Román</given-names>
</name>
<xref ref-type="aff" rid="Aff5">5</xref>
<xref ref-type="aff" rid="Aff7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cataliotti</surname>
<given-names>Alessandro</given-names>
</name>
<xref ref-type="aff" rid="Aff6">6</xref>
<xref ref-type="aff" rid="Aff7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Levy</surname>
<given-names>Finn Olav</given-names>
</name>
<xref ref-type="aff" rid="Aff5">5</xref>
<xref ref-type="aff" rid="Aff7">7</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Lukowski</surname>
<given-names>Robert</given-names>
</name>
<address><email>robert.lukowski@uni-tuebingen.de</email>
</address>
<xref ref-type="aff" rid="Aff8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Frankenreiter</surname>
<given-names>Sandra</given-names>
</name>
<xref ref-type="aff" rid="Aff8">8</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Friebe</surname>
<given-names>Andreas</given-names>
</name>
<address><email>andreas.friebe@uni-wuerzburg.de</email>
</address>
<xref ref-type="aff" rid="Aff9">9</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Calamaras</surname>
<given-names>Timothy</given-names>
</name>
<address><email>tcalamaras@tuftsmedicalcenter.org</email>
</address>
<xref ref-type="aff" rid="Aff10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baumgartner</surname>
<given-names>Robert</given-names>
</name>
<xref ref-type="aff" rid="Aff10">10</xref>
<xref ref-type="aff" rid="Aff11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>McLaughlin</surname>
<given-names>Angela</given-names>
</name>
<xref ref-type="aff" rid="Aff10">10</xref>
<xref ref-type="aff" rid="Aff12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aronovitz</surname>
<given-names>Mark</given-names>
</name>
<xref ref-type="aff" rid="Aff10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baur</surname>
<given-names>Wendy</given-names>
</name>
<xref ref-type="aff" rid="Aff10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Guang-Rong</given-names>
</name>
<xref ref-type="aff" rid="Aff10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kapur</surname>
<given-names>Navin</given-names>
</name>
<xref ref-type="aff" rid="Aff10">10</xref>
<xref ref-type="aff" rid="Aff13">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Karas</surname>
<given-names>Richard</given-names>
</name>
<xref ref-type="aff" rid="Aff10">10</xref>
<xref ref-type="aff" rid="Aff13">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Blanton</surname>
<given-names>Robert</given-names>
</name>
<xref ref-type="aff" rid="Aff10">10</xref>
<xref ref-type="aff" rid="Aff13">13</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Hell</surname>
<given-names>Stefan</given-names>
</name>
<address><email>hell@nanoscopy.de</email>
</address>
<xref ref-type="aff" rid="Aff14">14</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Waldman</surname>
<given-names>Scott A.</given-names>
</name>
<address><email>scott.waldman@jefferson.edu</email>
</address>
<xref ref-type="aff" rid="Aff15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lin</surname>
<given-names>Jieru E.</given-names>
</name>
<xref ref-type="aff" rid="Aff15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Colon-Gonzalez</surname>
<given-names>Francheska</given-names>
</name>
<xref ref-type="aff" rid="Aff15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kim</surname>
<given-names>Gilbert W.</given-names>
</name>
<xref ref-type="aff" rid="Aff15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Blomain</surname>
<given-names>Erik S.</given-names>
</name>
<xref ref-type="aff" rid="Aff15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Merlino</surname>
<given-names>Dante</given-names>
</name>
<xref ref-type="aff" rid="Aff15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Snook</surname>
<given-names>Adam</given-names>
</name>
<xref ref-type="aff" rid="Aff15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Erdmann</surname>
<given-names>Jeanette</given-names>
</name>
<address><email>jeanette.erdmann@uni-luebeck.de</email>
</address>
<xref ref-type="aff" rid="Aff16">16</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wobst</surname>
<given-names>Jana</given-names>
</name>
<xref ref-type="aff" rid="Aff17">17</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kessler</surname>
<given-names>Thorsten</given-names>
</name>
<xref ref-type="aff" rid="Aff17">17</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schunkert</surname>
<given-names>Heribert</given-names>
</name>
<xref ref-type="aff" rid="Aff17">17</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Walter</surname>
<given-names>Ulrich</given-names>
</name>
<address><email>ulrich.walter@uni-mainz.de</email>
</address>
<xref ref-type="aff" rid="Aff18">18</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pagel</surname>
<given-names>Oliver</given-names>
</name>
<xref ref-type="aff" rid="Aff19">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Walter</surname>
<given-names>Elena</given-names>
</name>
<xref ref-type="aff" rid="Aff18">18</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gambaryan</surname>
<given-names>Stepan</given-names>
</name>
<xref ref-type="aff" rid="Aff18">18</xref>
<xref ref-type="aff" rid="Aff20">20</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Smolenski</surname>
<given-names>Albert</given-names>
</name>
<xref ref-type="aff" rid="Aff21">21</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Jurk</surname>
<given-names>Kerstin</given-names>
</name>
<xref ref-type="aff" rid="Aff18">18</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Zahedi</surname>
<given-names>Rene</given-names>
</name>
<xref ref-type="aff" rid="Aff19">19</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Klinger</surname>
<given-names>James R.</given-names>
</name>
<address><email>james_klinger@brown.edu</email>
</address>
<xref ref-type="aff" rid="Aff22">22</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Benza</surname>
<given-names>Raymond L.</given-names>
</name>
<xref ref-type="aff" rid="Aff23">23</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Corris</surname>
<given-names>Paul A.</given-names>
</name>
<xref ref-type="aff" rid="Aff24">24</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Langleben</surname>
<given-names>David</given-names>
</name>
<xref ref-type="aff" rid="Aff25">25</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Naeije</surname>
<given-names>Robert</given-names>
</name>
<xref ref-type="aff" rid="Aff26">26</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Simonneau</surname>
<given-names>Gérald</given-names>
</name>
<xref ref-type="aff" rid="Aff27">27</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Meier</surname>
<given-names>Christian</given-names>
</name>
<xref ref-type="aff" rid="Aff28">28</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Colorado</surname>
<given-names>Pablo</given-names>
</name>
<xref ref-type="aff" rid="Aff29">29</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chang</surname>
<given-names>Mi Kyung</given-names>
</name>
<xref ref-type="aff" rid="Aff28">28</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Busse</surname>
<given-names>Dennis</given-names>
</name>
<xref ref-type="aff" rid="Aff30">30</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hoeper</surname>
<given-names>Marius M.</given-names>
</name>
<xref ref-type="aff" rid="Aff31">31</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Masferrer</surname>
<given-names>Jaime L.</given-names>
</name>
<address><email>jmasferrer@ironwoodpharma.com</email>
</address>
<xref ref-type="aff" rid="Aff32">32</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jacobson</surname>
<given-names>Sarah</given-names>
</name>
<xref ref-type="aff" rid="Aff32">32</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Liu</surname>
<given-names>Guang</given-names>
</name>
<xref ref-type="aff" rid="Aff32">32</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sarno</surname>
<given-names>Renee</given-names>
</name>
<xref ref-type="aff" rid="Aff32">32</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bernier</surname>
<given-names>Sylvie</given-names>
</name>
<xref ref-type="aff" rid="Aff32">32</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhang</surname>
<given-names>Ping</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Todd Milne</surname>
<given-names>G.</given-names>
</name>
<xref ref-type="aff" rid="Aff32">32</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Flores-Costa</surname>
<given-names>Roger</given-names>
</name>
<xref ref-type="aff" rid="Aff33">33</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Currie</surname>
<given-names>Mark</given-names>
</name>
<xref ref-type="aff" rid="Aff32">32</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hall</surname>
<given-names>Katherine</given-names>
</name>
<xref ref-type="aff" rid="Aff32">32</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Möhrle</surname>
<given-names>Dorit</given-names>
</name>
<address><email>dorit.moehrle@uni-tuebingen.de</email>
</address>
<xref ref-type="aff" rid="Aff34">34</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Reimann</surname>
<given-names>Katrin</given-names>
</name>
<xref ref-type="aff" rid="Aff34">34</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wolter</surname>
<given-names>Steffen</given-names>
</name>
<xref ref-type="aff" rid="Aff34">34</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wolters</surname>
<given-names>Markus</given-names>
</name>
<xref ref-type="aff" rid="Aff35">35</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mergia</surname>
<given-names>Evanthia</given-names>
</name>
<xref ref-type="aff" rid="Aff36">36</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Eichert</surname>
<given-names>Nicole</given-names>
</name>
<xref ref-type="aff" rid="Aff34">34</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Geisler</surname>
<given-names>Hyun-Soon</given-names>
</name>
<xref ref-type="aff" rid="Aff34">34</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ruth</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="Aff37">37</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Friebe</surname>
<given-names>Andreas</given-names>
</name>
<xref ref-type="aff" rid="Aff38">38</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Feil</surname>
<given-names>Robert</given-names>
</name>
<xref ref-type="aff" rid="Aff35">35</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zimmermann</surname>
<given-names>Ulrike</given-names>
</name>
<xref ref-type="aff" rid="Aff34">34</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Koesling</surname>
<given-names>Doris</given-names>
</name>
<xref ref-type="aff" rid="Aff36">36</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Knipper</surname>
<given-names>Marlies</given-names>
</name>
<xref ref-type="aff" rid="Aff34">34</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rüttiger</surname>
<given-names>Lukas</given-names>
</name>
<xref ref-type="aff" rid="Aff34">34</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tanaka</surname>
<given-names>Yasutake</given-names>
</name>
<xref ref-type="aff" rid="Aff39">39</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Okamoto</surname>
<given-names>Atsuko</given-names>
</name>
<xref ref-type="aff" rid="Aff39">39</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Nojiri</surname>
<given-names>Takashi</given-names>
</name>
<address><email>nojiri@ri.ncvc.go.jp</email>
</address>
<xref ref-type="aff" rid="Aff39">39</xref>
<xref ref-type="aff" rid="Aff40">40</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kumazoe</surname>
<given-names>Motofumi</given-names>
</name>
<xref ref-type="aff" rid="Aff39">39</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tokudome</surname>
<given-names>Takeshi</given-names>
</name>
<xref ref-type="aff" rid="Aff39">39</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Miura</surname>
<given-names>Koichi</given-names>
</name>
<xref ref-type="aff" rid="Aff39">39</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hino</surname>
<given-names>Jun</given-names>
</name>
<xref ref-type="aff" rid="Aff39">39</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hosoda</surname>
<given-names>Hiroshi</given-names>
</name>
<xref ref-type="aff" rid="Aff41">41</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Miyazato</surname>
<given-names>Mikiya</given-names>
</name>
<xref ref-type="aff" rid="Aff39">39</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kangawa</surname>
<given-names>Kenji</given-names>
</name>
<xref ref-type="aff" rid="Aff39">39</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Kapil</surname>
<given-names>Vikas</given-names>
</name>
<address><email>v.kapil@qmul.ac.uk</email>
</address>
<xref ref-type="aff" rid="Aff42">42</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ahluwalia</surname>
<given-names>Amrita</given-names>
</name>
<xref ref-type="aff" rid="Aff42">42</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Paolocci</surname>
<given-names>Nazareno</given-names>
</name>
<address><email>npaoloc1@jhmi.edu</email>
</address>
<xref ref-type="aff" rid="Aff43">43</xref>
<xref ref-type="aff" rid="Aff44">44</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Eaton</surname>
<given-names>Philip</given-names>
</name>
<address><email>philip.eaton@kcl.ac.uk</email>
</address>
<xref ref-type="aff" rid="Aff45">45</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Campbell</surname>
<given-names>James C.</given-names>
</name>
<xref ref-type="aff" rid="Aff46">46</xref>
<xref ref-type="aff" rid="Aff47">47</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Henning</surname>
<given-names>Philipp</given-names>
</name>
<xref ref-type="aff" rid="Aff48">48</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Franz</surname>
<given-names>Eugen</given-names>
</name>
<xref ref-type="aff" rid="Aff48">48</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sankaran</surname>
<given-names>Banumathi</given-names>
</name>
<xref ref-type="aff" rid="Aff49">49</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Herberg</surname>
<given-names>Friedrich W.</given-names>
</name>
<xref ref-type="aff" rid="Aff49">49</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Kim</surname>
<given-names>Choel</given-names>
</name>
<address><email>ckim@bcm.edu</email>
</address>
<xref ref-type="aff" rid="Aff46">46</xref>
<xref ref-type="aff" rid="Aff47">47</xref>
<xref ref-type="aff" rid="Aff50">50</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wittwer</surname>
<given-names>M.</given-names>
</name>
<xref ref-type="aff" rid="Aff51">51</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Luo</surname>
<given-names>Q.</given-names>
</name>
<xref ref-type="aff" rid="Aff52">52</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kaila</surname>
<given-names>V.</given-names>
</name>
<xref ref-type="aff" rid="Aff52">52</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Dames</surname>
<given-names>S. A.</given-names>
</name>
<address><email>sonja.dames@tum.de</email>
</address>
<xref ref-type="aff" rid="Aff51">51</xref>
<xref ref-type="aff" rid="Aff53">53</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Tobin</surname>
<given-names>Andrew</given-names>
</name>
<address><email>Andrew.Tobin@glasgow.ac.uk</email>
</address>
<xref ref-type="aff" rid="Aff54">54</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Alam</surname>
<given-names>Mahmood</given-names>
</name>
<xref ref-type="aff" rid="Aff54">54</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Rudyk</surname>
<given-names>Olena</given-names>
</name>
<address><email>olena.rudyk@kcl.ac.uk</email>
</address>
<xref ref-type="aff" rid="Aff55">55</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Krasemann</surname>
<given-names>Susanne</given-names>
</name>
<xref ref-type="aff" rid="Aff56">56</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hartmann</surname>
<given-names>Kristin</given-names>
</name>
<xref ref-type="aff" rid="Aff56">56</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Prysyazhna</surname>
<given-names>Oleksandra</given-names>
</name>
<xref ref-type="aff" rid="Aff55">55</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhang</surname>
<given-names>Min</given-names>
</name>
<xref ref-type="aff" rid="Aff55">55</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhao</surname>
<given-names>Lan</given-names>
</name>
<xref ref-type="aff" rid="Aff57">57</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Weiss</surname>
<given-names>Astrid</given-names>
</name>
<xref ref-type="aff" rid="Aff58">58</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schermuly</surname>
<given-names>Ralph</given-names>
</name>
<xref ref-type="aff" rid="Aff58">58</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Eaton</surname>
<given-names>Philip</given-names>
</name>
<xref ref-type="aff" rid="Aff55">55</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Moyes</surname>
<given-names>Amie J.</given-names>
</name>
<address><email>a.j.moyes@qmul.ac.uk</email>
</address>
<xref ref-type="aff" rid="Aff59">59</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chu</surname>
<given-names>Sandy M.</given-names>
</name>
<xref ref-type="aff" rid="Aff59">59</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baliga</surname>
<given-names>Reshma S.</given-names>
</name>
<xref ref-type="aff" rid="Aff59">59</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hobbs</surname>
<given-names>Adrian J.</given-names>
</name>
<xref ref-type="aff" rid="Aff59">59</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Michalakis</surname>
<given-names>Stylianos</given-names>
</name>
<address><email>michalakis@lmu.de</email>
</address>
<xref ref-type="aff" rid="Aff60">60</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mühlfriedel</surname>
<given-names>Regine</given-names>
</name>
<xref ref-type="aff" rid="Aff61">61</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schön</surname>
<given-names>Christian</given-names>
</name>
<xref ref-type="aff" rid="Aff60">60</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fischer</surname>
<given-names>Dominik M.</given-names>
</name>
<xref ref-type="aff" rid="Aff62">62</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wilhelm</surname>
<given-names>Barbara</given-names>
</name>
<xref ref-type="aff" rid="Aff63">63</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zobor</surname>
<given-names>Ditta</given-names>
</name>
<xref ref-type="aff" rid="Aff62">62</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kohl</surname>
<given-names>Susanne</given-names>
</name>
<xref ref-type="aff" rid="Aff61">61</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Peters</surname>
<given-names>Tobias</given-names>
</name>
<xref ref-type="aff" rid="Aff63">63</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zrenner</surname>
<given-names>Eberhart</given-names>
</name>
<xref ref-type="aff" rid="Aff61">61</xref>
<xref ref-type="aff" rid="Aff62">62</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bartz-Schmidt</surname>
<given-names>Karl Ulrich</given-names>
</name>
<xref ref-type="aff" rid="Aff62">62</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ueffing</surname>
<given-names>Marius</given-names>
</name>
<xref ref-type="aff" rid="Aff62">62</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wissinger</surname>
<given-names>Bernd</given-names>
</name>
<xref ref-type="aff" rid="Aff62">62</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Seeliger</surname>
<given-names>Mathias</given-names>
</name>
<xref ref-type="aff" rid="Aff62">62</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Biel</surname>
<given-names>Martin</given-names>
</name>
<xref ref-type="aff" rid="Aff60">60</xref>
</contrib>
<contrib contrib-type="author"><collab>RD-CURE consortium</collab>
</contrib>
<contrib contrib-type="author"><name><surname>Ranek</surname>
<given-names>Mark J.</given-names>
</name>
<xref ref-type="aff" rid="Aff64">64</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kokkonen</surname>
<given-names>Kristen M.</given-names>
</name>
<xref ref-type="aff" rid="Aff64">64</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lee</surname>
<given-names>Dong I.</given-names>
</name>
<xref ref-type="aff" rid="Aff64">64</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Holewinski</surname>
<given-names>Ronald J.</given-names>
</name>
<xref ref-type="aff" rid="Aff65">65</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Agrawal</surname>
<given-names>Vineet</given-names>
</name>
<xref ref-type="aff" rid="Aff64">64</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Virus</surname>
<given-names>Cornelia</given-names>
</name>
<xref ref-type="aff" rid="Aff66">66</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stevens</surname>
<given-names>Donté A.</given-names>
</name>
<xref ref-type="aff" rid="Aff66">66</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sasaki</surname>
<given-names>Masayuki</given-names>
</name>
<xref ref-type="aff" rid="Aff64">64</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhang</surname>
<given-names>Huaqun</given-names>
</name>
<xref ref-type="aff" rid="Aff67">67</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mannion</surname>
<given-names>Mathew M.</given-names>
</name>
<xref ref-type="aff" rid="Aff67">67</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rainer</surname>
<given-names>Peter P.</given-names>
</name>
<xref ref-type="aff" rid="Aff64">64</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Page</surname>
<given-names>Richard C.</given-names>
</name>
<xref ref-type="aff" rid="Aff67">67</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schisler</surname>
<given-names>Jonathan C.</given-names>
</name>
<xref ref-type="aff" rid="Aff66">66</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Van Eyk</surname>
<given-names>Jennifer E.</given-names>
</name>
<xref ref-type="aff" rid="Aff65">65</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Willis</surname>
<given-names>Monte S.</given-names>
</name>
<xref ref-type="aff" rid="Aff66">66</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Kass</surname>
<given-names>David A.</given-names>
</name>
<address><email>dkass@jhmi.edu</email>
</address>
<xref ref-type="aff" rid="Aff64">64</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Zaccolo</surname>
<given-names>Manuela</given-names>
</name>
<address><email>manuela.zaccolo@dpag.ox.ac.uk</email>
</address>
<xref ref-type="aff" rid="Aff68">68</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Russwurm</surname>
<given-names>Michael</given-names>
</name>
<address><email>michael.russwurm@ruhr-uni-bochum.de</email>
</address>
<xref ref-type="aff" rid="Aff69">69</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Giesen</surname>
<given-names>Jan</given-names>
</name>
<xref ref-type="aff" rid="Aff69">69</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Russwurm</surname>
<given-names>Corina</given-names>
</name>
<xref ref-type="aff" rid="Aff69">69</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Füchtbauer</surname>
<given-names>Ernst-Martin</given-names>
</name>
<xref ref-type="aff" rid="Aff70">70</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Koesling</surname>
<given-names>Doris</given-names>
</name>
<xref ref-type="aff" rid="Aff69">69</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Bork</surname>
<given-names>Nadja I.</given-names>
</name>
<address><email>n.bork@uke.de</email>
</address>
<xref ref-type="aff" rid="Aff71">71</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nikolaev</surname>
<given-names>Viacheslav O.</given-names>
</name>
<xref ref-type="aff" rid="Aff71">71</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Agulló</surname>
<given-names>Luis</given-names>
</name>
<address><email>luis.agullo@uvic.cat</email>
</address>
<xref ref-type="aff" rid="Aff72">72</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Floor</surname>
<given-names>Martin</given-names>
</name>
<xref ref-type="aff" rid="Aff72">72</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Villà-Freixa</surname>
<given-names>Jordi</given-names>
</name>
<xref ref-type="aff" rid="Aff72">72</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Manfra</surname>
<given-names>Ornella</given-names>
</name>
<xref ref-type="aff" rid="Aff73">73</xref>
<xref ref-type="aff" rid="Aff74">74</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Calamera</surname>
<given-names>Gaia</given-names>
</name>
<xref ref-type="aff" rid="Aff73">73</xref>
<xref ref-type="aff" rid="Aff74">74</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Surdo</surname>
<given-names>Nicoletta C.</given-names>
</name>
<xref ref-type="aff" rid="Aff75">75</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Meier</surname>
<given-names>Silja</given-names>
</name>
<xref ref-type="aff" rid="Aff73">73</xref>
<xref ref-type="aff" rid="Aff74">74</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Froese</surname>
<given-names>Alexander</given-names>
</name>
<xref ref-type="aff" rid="Aff76">76</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nikolaev</surname>
<given-names>Viacheslav O.</given-names>
</name>
<xref ref-type="aff" rid="Aff76">76</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zaccolo</surname>
<given-names>Manuela</given-names>
</name>
<xref ref-type="aff" rid="Aff75">75</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Levy</surname>
<given-names>Finn Olav</given-names>
</name>
<xref ref-type="aff" rid="Aff73">73</xref>
<xref ref-type="aff" rid="Aff74">74</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Andressen</surname>
<given-names>Kjetil Wessel</given-names>
</name>
<address><email>kjetilwa@medisin.uio.no</email>
</address>
<xref ref-type="aff" rid="Aff73">73</xref>
<xref ref-type="aff" rid="Aff74">74</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Aue</surname>
<given-names>Annemarie</given-names>
</name>
<address><email>annemarie.aue@uni-wuerzburg.de</email>
</address>
<xref ref-type="aff" rid="Aff77">77</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schwiering</surname>
<given-names>Fabian</given-names>
</name>
<xref ref-type="aff" rid="Aff77">77</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Groneberg</surname>
<given-names>Dieter</given-names>
</name>
<xref ref-type="aff" rid="Aff77">77</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Friebe</surname>
<given-names>Andreas</given-names>
</name>
<xref ref-type="aff" rid="Aff77">77</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Bajraktari</surname>
<given-names>Gzona</given-names>
</name>
<address><email>gzona.bajraktari@med.uni-heidelberg.de</email>
</address>
<xref ref-type="aff" rid="Aff78">78</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Burhenne</surname>
<given-names>Jürgen</given-names>
</name>
<xref ref-type="aff" rid="Aff78">78</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Haefeli</surname>
<given-names>Walter E.</given-names>
</name>
<xref ref-type="aff" rid="Aff78">78</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Weiss</surname>
<given-names>Johanna</given-names>
</name>
<xref ref-type="aff" rid="Aff78">78</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Beck</surname>
<given-names>Katharina</given-names>
</name>
<address><email>katharina.beck1@uni-wuerzburg.de</email>
</address>
<xref ref-type="aff" rid="Aff79">79</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Voussen</surname>
<given-names>Barbara</given-names>
</name>
<xref ref-type="aff" rid="Aff79">79</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vincent</surname>
<given-names>Alexander</given-names>
</name>
<xref ref-type="aff" rid="Aff80">80</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Parsons</surname>
<given-names>Sean P.</given-names>
</name>
<xref ref-type="aff" rid="Aff80">80</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Huizinga</surname>
<given-names>Jan D.</given-names>
</name>
<xref ref-type="aff" rid="Aff80">80</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Friebe</surname>
<given-names>Andreas</given-names>
</name>
<xref ref-type="aff" rid="Aff79">79</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mónica</surname>
<given-names>Fabiola Zakia</given-names>
</name>
<xref ref-type="aff" rid="Aff81">81</xref>
<xref ref-type="aff" rid="Aff82">82</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Seto</surname>
<given-names>Edward</given-names>
</name>
<xref ref-type="aff" rid="Aff81">81</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Murad</surname>
<given-names>Ferid</given-names>
</name>
<xref ref-type="aff" rid="Aff81">81</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Bian</surname>
<given-names>Ka</given-names>
</name>
<address><email>bcmkxb@gwu.edu</email>
</address>
<xref ref-type="aff" rid="Aff81">81</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Burgoyne</surname>
<given-names>Joseph R.</given-names>
</name>
<address><email>joseph.burgoyne@kcl.ac.uk</email>
</address>
<xref ref-type="aff" rid="Aff83">83</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Prysyazhna</surname>
<given-names>Oleksandra</given-names>
</name>
<xref ref-type="aff" rid="Aff83">83</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Richards</surname>
<given-names>Daniel</given-names>
</name>
<xref ref-type="aff" rid="Aff83">83</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Eaton</surname>
<given-names>Philip</given-names>
</name>
<xref ref-type="aff" rid="Aff83">83</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Calamera</surname>
<given-names>Gaia</given-names>
</name>
<address><email>gaia.calamera@studmed.uio.no</email>
</address>
<xref ref-type="aff" rid="Aff84">84</xref>
<xref ref-type="aff" rid="Aff85">85</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bjørnerem</surname>
<given-names>Marianne</given-names>
</name>
<xref ref-type="aff" rid="Aff84">84</xref>
<xref ref-type="aff" rid="Aff85">85</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ulsund</surname>
<given-names>Andrea Hembre</given-names>
</name>
<xref ref-type="aff" rid="Aff84">84</xref>
<xref ref-type="aff" rid="Aff85">85</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kim</surname>
<given-names>Jeong Joo</given-names>
</name>
<xref ref-type="aff" rid="Aff86">86</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kim</surname>
<given-names>Choel</given-names>
</name>
<xref ref-type="aff" rid="Aff86">86</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Levy</surname>
<given-names>Finn Olav</given-names>
</name>
<xref ref-type="aff" rid="Aff84">84</xref>
<xref ref-type="aff" rid="Aff85">85</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Andressen</surname>
<given-names>Kjetil Wessel</given-names>
</name>
<xref ref-type="aff" rid="Aff84">84</xref>
<xref ref-type="aff" rid="Aff85">85</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Donzelli</surname>
<given-names>Sonia</given-names>
</name>
<xref ref-type="aff" rid="Aff87">87</xref>
<xref ref-type="aff" rid="Aff88">88</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Goetz</surname>
<given-names>Mara</given-names>
</name>
<xref ref-type="aff" rid="Aff87">87</xref>
<xref ref-type="aff" rid="Aff88">88</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schmidt</surname>
<given-names>Kjestine</given-names>
</name>
<xref ref-type="aff" rid="Aff88">88</xref>
<xref ref-type="aff" rid="Aff89">89</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wolters</surname>
<given-names>Markus</given-names>
</name>
<xref ref-type="aff" rid="Aff90">90</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stathopoulou</surname>
<given-names>Konstantina</given-names>
</name>
<xref ref-type="aff" rid="Aff87">87</xref>
<xref ref-type="aff" rid="Aff88">88</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Prysyazhna</surname>
<given-names>Oleksandra</given-names>
</name>
<xref ref-type="aff" rid="Aff91">91</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Scotcher</surname>
<given-names>Jenna</given-names>
</name>
<xref ref-type="aff" rid="Aff91">91</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dees</surname>
<given-names>Christian</given-names>
</name>
<xref ref-type="aff" rid="Aff92">92</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Subramanian</surname>
<given-names>Hariharan</given-names>
</name>
<xref ref-type="aff" rid="Aff88">88</xref>
<xref ref-type="aff" rid="Aff93">93</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Butt</surname>
<given-names>Elke</given-names>
</name>
<xref ref-type="aff" rid="Aff92">92</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kamynina</surname>
<given-names>Alisa</given-names>
</name>
<xref ref-type="aff" rid="Aff91">91</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bruce King</surname>
<given-names>S.</given-names>
</name>
<xref ref-type="aff" rid="Aff94">94</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nikolaev</surname>
<given-names>Viacheslav O.</given-names>
</name>
<xref ref-type="aff" rid="Aff88">88</xref>
<xref ref-type="aff" rid="Aff93">93</xref>
</contrib>
<contrib contrib-type="author"><name><surname>de Witt</surname>
<given-names>Cor</given-names>
</name>
<xref ref-type="aff" rid="Aff88">88</xref>
<xref ref-type="aff" rid="Aff89">89</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Leichert</surname>
<given-names>Lars I.</given-names>
</name>
<xref ref-type="aff" rid="Aff95">95</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Feil</surname>
<given-names>Robert</given-names>
</name>
<xref ref-type="aff" rid="Aff90">90</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Eaton</surname>
<given-names>Philip</given-names>
</name>
<xref ref-type="aff" rid="Aff91">91</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Cuello</surname>
<given-names>Friederike</given-names>
</name>
<address><email>f.cuello@uke.de</email>
</address>
<xref ref-type="aff" rid="Aff87">87</xref>
<xref ref-type="aff" rid="Aff88">88</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Dobrowinski</surname>
<given-names>Hyazinth</given-names>
</name>
<address><email>hyazinth.dobrowinski@ifib.uni-tuebingen.de</email>
</address>
<xref ref-type="aff" rid="Aff96">96</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lehners</surname>
<given-names>Moritz</given-names>
</name>
<xref ref-type="aff" rid="Aff96">96</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schmidt</surname>
<given-names>Michael Paolillo Hannes</given-names>
</name>
<xref ref-type="aff" rid="Aff96">96</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Feil</surname>
<given-names>Robert</given-names>
</name>
<xref ref-type="aff" rid="Aff96">96</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Feil</surname>
<given-names>Susanne</given-names>
</name>
<address><email>susanne.feil@uni-tuebingen.de</email>
</address>
<xref ref-type="aff" rid="Aff97">97</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wen</surname>
<given-names>Lai</given-names>
</name>
<xref ref-type="aff" rid="Aff97">97</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wolters</surname>
<given-names>Markus</given-names>
</name>
<xref ref-type="aff" rid="Aff97">97</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Thunemann</surname>
<given-names>Martin</given-names>
</name>
<xref ref-type="aff" rid="Aff97">97</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schmidt</surname>
<given-names>Kjestine</given-names>
</name>
<xref ref-type="aff" rid="Aff98">98</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Olbrich</surname>
<given-names>Marcus</given-names>
</name>
<xref ref-type="aff" rid="Aff99">99</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Langer</surname>
<given-names>Harald</given-names>
</name>
<xref ref-type="aff" rid="Aff99">99</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gawaz</surname>
<given-names>Meinrad</given-names>
</name>
<xref ref-type="aff" rid="Aff99">99</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Friebe</surname>
<given-names>Andreas</given-names>
</name>
<xref ref-type="aff" rid="Aff100">100</xref>
</contrib>
<contrib contrib-type="author"><name><surname>de Wit</surname>
<given-names>Cor</given-names>
</name>
<xref ref-type="aff" rid="Aff98">98</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Feil</surname>
<given-names>Robert</given-names>
</name>
<xref ref-type="aff" rid="Aff97">97</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Franz</surname>
<given-names>Eugen</given-names>
</name>
<address><email>franz.eugen@uni-kassel.de</email>
</address>
<xref ref-type="aff" rid="Aff101">101</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kim</surname>
<given-names>Jeong Joo</given-names>
</name>
<xref ref-type="aff" rid="Aff101">101</xref>
<xref ref-type="aff" rid="Aff102">102</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bertinetti</surname>
<given-names>Daniela</given-names>
</name>
<xref ref-type="aff" rid="Aff101">101</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kim</surname>
<given-names>Choel</given-names>
</name>
<xref ref-type="aff" rid="Aff102">102</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Herberg</surname>
<given-names>Friedrich W.</given-names>
</name>
<xref ref-type="aff" rid="Aff101">101</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ghofrani</surname>
<given-names>Hossein-Ardeschir</given-names>
</name>
<address><email>ardeschir.ghofrani@innere.med.uni-giessen.de</email>
</address>
<xref ref-type="aff" rid="Aff103">103</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Grimminger</surname>
<given-names>Friedrich</given-names>
</name>
<xref ref-type="aff" rid="Aff103">103</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Grünig</surname>
<given-names>Ekkehard</given-names>
</name>
<xref ref-type="aff" rid="Aff104">104</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Huang</surname>
<given-names>Yigao</given-names>
</name>
<xref ref-type="aff" rid="Aff105">105</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jansa</surname>
<given-names>Pavel</given-names>
</name>
<xref ref-type="aff" rid="Aff106">106</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jing</surname>
<given-names>Zhi Cheng</given-names>
</name>
<xref ref-type="aff" rid="Aff107">107</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kilpatrick</surname>
<given-names>David</given-names>
</name>
<xref ref-type="aff" rid="Aff108">108</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Langleben</surname>
<given-names>David</given-names>
</name>
<xref ref-type="aff" rid="Aff109">109</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rosenkranz</surname>
<given-names>Stephan</given-names>
</name>
<xref ref-type="aff" rid="Aff110">110</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Menezes</surname>
<given-names>Flavia</given-names>
</name>
<xref ref-type="aff" rid="Aff111">111</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fritsch</surname>
<given-names>Arno</given-names>
</name>
<xref ref-type="aff" rid="Aff112">112</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nikkho</surname>
<given-names>Sylvia</given-names>
</name>
<xref ref-type="aff" rid="Aff113">113</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Frey</surname>
<given-names>Reiner</given-names>
</name>
<xref ref-type="aff" rid="Aff113">113</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Humbert</surname>
<given-names>Marc</given-names>
</name>
<xref ref-type="aff" rid="Aff114">114</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Groneberg</surname>
<given-names>Dieter</given-names>
</name>
<address><email>dieter.groneberg@uni-wuerzburg.de</email>
</address>
<xref ref-type="aff" rid="Aff115">115</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aue</surname>
<given-names>Annemarie</given-names>
</name>
<xref ref-type="aff" rid="Aff115">115</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schwiering</surname>
<given-names>Fabian</given-names>
</name>
<xref ref-type="aff" rid="Aff115">115</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Friebe</surname>
<given-names>Andreas</given-names>
</name>
<xref ref-type="aff" rid="Aff115">115</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Harloff</surname>
<given-names>Manuela</given-names>
</name>
<address><email>manuela.harloff@ur.de</email>
</address>
<xref ref-type="aff" rid="Aff116">116</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Reinders</surname>
<given-names>Joerg</given-names>
</name>
<xref ref-type="aff" rid="Aff117">117</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schlossmann</surname>
<given-names>Jens</given-names>
</name>
<xref ref-type="aff" rid="Aff116">116</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Jung</surname>
<given-names>Joon</given-names>
</name>
<address><email>jjung@ironwoodpharma.com</email>
</address>
<xref ref-type="aff" rid="Aff118">118</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wales</surname>
<given-names>Jessica A.</given-names>
</name>
<xref ref-type="aff" rid="Aff119">119</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Cheng-Yu</given-names>
</name>
<xref ref-type="aff" rid="Aff119">119</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Breci</surname>
<given-names>Linda</given-names>
</name>
<xref ref-type="aff" rid="Aff119">119</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Weichsel</surname>
<given-names>Andrzej</given-names>
</name>
<xref ref-type="aff" rid="Aff119">119</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bernier</surname>
<given-names>Sylvie G.</given-names>
</name>
<xref ref-type="aff" rid="Aff118">118</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Solinga</surname>
<given-names>Robert</given-names>
</name>
<xref ref-type="aff" rid="Aff118">118</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sheppeck</surname>
<given-names>James E.</given-names>
<suffix>II</suffix>
</name>
<xref ref-type="aff" rid="Aff118">118</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Renhowe</surname>
<given-names>Paul A.</given-names>
</name>
<xref ref-type="aff" rid="Aff118">118</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Montfort</surname>
<given-names>William R.</given-names>
</name>
<xref ref-type="aff" rid="Aff119">119</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Qin</surname>
<given-names>Liying</given-names>
</name>
<address><email>Liying.Qin@bcm.edu</email>
</address>
<xref ref-type="aff" rid="Aff120">120</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sung</surname>
<given-names>Ying-Ju</given-names>
</name>
<xref ref-type="aff" rid="Aff121">121</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Casteel</surname>
<given-names>Darren</given-names>
</name>
<xref ref-type="aff" rid="Aff122">122</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kim</surname>
<given-names>Choel</given-names>
</name>
<xref ref-type="aff" rid="Aff120">120</xref>
<xref ref-type="aff" rid="Aff123">123</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Kollau</surname>
<given-names>Alexander</given-names>
</name>
<address><email>alexander.kollau@uni-graz.at</email>
</address>
<xref ref-type="aff" rid="Aff124">124</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Neubauer</surname>
<given-names>Andrea</given-names>
</name>
<xref ref-type="aff" rid="Aff124">124</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schrammel</surname>
<given-names>Astrid</given-names>
</name>
<xref ref-type="aff" rid="Aff124">124</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Russwurm</surname>
<given-names>Michael</given-names>
</name>
<xref ref-type="aff" rid="Aff125">125</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Koesling</surname>
<given-names>Doris</given-names>
</name>
<xref ref-type="aff" rid="Aff125">125</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mayer</surname>
<given-names>Bernd</given-names>
</name>
<xref ref-type="aff" rid="Aff124">124</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Kumazoe</surname>
<given-names>Motofumi</given-names>
</name>
<xref ref-type="aff" rid="Aff126">126</xref>
<xref ref-type="aff" rid="Aff127">127</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Takai</surname>
<given-names>Mika</given-names>
</name>
<xref ref-type="aff" rid="Aff126">126</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Takeuchi</surname>
<given-names>Chieri</given-names>
</name>
<xref ref-type="aff" rid="Aff126">126</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kadomatsu</surname>
<given-names>Mai</given-names>
</name>
<xref ref-type="aff" rid="Aff126">126</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hiroi</surname>
<given-names>Shun</given-names>
</name>
<xref ref-type="aff" rid="Aff126">126</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Takamatsu</surname>
<given-names>Kanako</given-names>
</name>
<xref ref-type="aff" rid="Aff126">126</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nojiri</surname>
<given-names>Takashi</given-names>
</name>
<xref ref-type="aff" rid="Aff127">127</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kangawa</surname>
<given-names>Kenji</given-names>
</name>
<xref ref-type="aff" rid="Aff127">127</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Tachibana</surname>
<given-names>Hirofumi</given-names>
</name>
<address><email>tatibana@agr.kyushu-u.ac.jp</email>
</address>
<xref ref-type="aff" rid="Aff126">126</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Opelt</surname>
<given-names>Marissa</given-names>
</name>
<xref ref-type="aff" rid="Aff128">128</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Eroglu</surname>
<given-names>Emrah</given-names>
</name>
<xref ref-type="aff" rid="Aff129">129</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Waldeck-Weiermair</surname>
<given-names>Markus</given-names>
</name>
<xref ref-type="aff" rid="Aff129">129</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Russwurm</surname>
<given-names>Michael</given-names>
</name>
<xref ref-type="aff" rid="Aff130">130</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Koesling</surname>
<given-names>Doris</given-names>
</name>
<xref ref-type="aff" rid="Aff130">130</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Malli</surname>
<given-names>Roland</given-names>
</name>
<xref ref-type="aff" rid="Aff129">129</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Graier</surname>
<given-names>Wolfgang F.</given-names>
</name>
<xref ref-type="aff" rid="Aff129">129</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fassett</surname>
<given-names>John T.</given-names>
</name>
<xref ref-type="aff" rid="Aff128">128</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schrammel</surname>
<given-names>Astrid</given-names>
</name>
<xref ref-type="aff" rid="Aff128">128</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Mayer</surname>
<given-names>Bernd</given-names>
</name>
<address><email>bernhard-michael.mayer@uni-graz.at</email>
</address>
<xref ref-type="aff" rid="Aff128">128</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sollie</surname>
<given-names>Selene J.</given-names>
</name>
<xref ref-type="aff" rid="Aff131">131</xref>
<xref ref-type="aff" rid="Aff132">132</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Moltzau</surname>
<given-names>Lise Román</given-names>
</name>
<address><email>l.r.moltzau@medisin.uio.no</email>
</address>
<xref ref-type="aff" rid="Aff131">131</xref>
<xref ref-type="aff" rid="Aff132">132</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hernandez-Valladares</surname>
<given-names>Maria</given-names>
</name>
<xref ref-type="aff" rid="Aff133">133</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Berven</surname>
<given-names>Frode</given-names>
</name>
<xref ref-type="aff" rid="Aff133">133</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Levy</surname>
<given-names>Finn Olav</given-names>
</name>
<xref ref-type="aff" rid="Aff131">131</xref>
<xref ref-type="aff" rid="Aff132">132</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Andressen</surname>
<given-names>Kjetil W.</given-names>
</name>
<xref ref-type="aff" rid="Aff131">131</xref>
<xref ref-type="aff" rid="Aff132">132</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Nojiri</surname>
<given-names>Takashi</given-names>
</name>
<address><email>nojiri@ri.ncvc.go.jp</email>
</address>
<xref ref-type="aff" rid="Aff134">134</xref>
<xref ref-type="aff" rid="Aff135">135</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tokudome</surname>
<given-names>Takeshi</given-names>
</name>
<xref ref-type="aff" rid="Aff134">134</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kumazoe</surname>
<given-names>Motofumi</given-names>
</name>
<xref ref-type="aff" rid="Aff134">134</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Arai</surname>
<given-names>Miki</given-names>
</name>
<xref ref-type="aff" rid="Aff136">136</xref>
<xref ref-type="aff" rid="Aff137">137</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Suzuki</surname>
<given-names>Yutaka</given-names>
</name>
<xref ref-type="aff" rid="Aff137">137</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Miura</surname>
<given-names>Koichi</given-names>
</name>
<xref ref-type="aff" rid="Aff134">134</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hino</surname>
<given-names>Jun</given-names>
</name>
<xref ref-type="aff" rid="Aff134">134</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hosoda</surname>
<given-names>Hiroshi</given-names>
</name>
<xref ref-type="aff" rid="Aff138">138</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Miyazato</surname>
<given-names>Mikiya</given-names>
</name>
<xref ref-type="aff" rid="Aff134">134</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Okumura</surname>
<given-names>Meinoshin</given-names>
</name>
<xref ref-type="aff" rid="Aff135">135</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kawaoka</surname>
<given-names>Shinpei</given-names>
</name>
<xref ref-type="aff" rid="Aff136">136</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kangawa</surname>
<given-names>Kenji</given-names>
</name>
<xref ref-type="aff" rid="Aff134">134</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Peters</surname>
<given-names>Stefanie</given-names>
</name>
<address><email>stefanie.peters@uni-tuebingen.de</email>
</address>
<xref ref-type="aff" rid="Aff139">139</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schmidt</surname>
<given-names>Hannes</given-names>
</name>
<xref ref-type="aff" rid="Aff140">140</xref>
<xref ref-type="aff" rid="Aff143">143</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Selin Kenet</surname>
<given-names>B.</given-names>
</name>
<xref ref-type="aff" rid="Aff139">139</xref>
<xref ref-type="aff" rid="Aff141">141</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nies</surname>
<given-names>Sarah Helena</given-names>
</name>
<xref ref-type="aff" rid="Aff139">139</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Frank</surname>
<given-names>Katharina</given-names>
</name>
<xref ref-type="aff" rid="Aff140">140</xref>
<xref ref-type="aff" rid="Aff142">142</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wen</surname>
<given-names>Lai</given-names>
</name>
<xref ref-type="aff" rid="Aff139">139</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rathjen</surname>
<given-names>Fritz G.</given-names>
</name>
<xref ref-type="aff" rid="Aff140">140</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Feil</surname>
<given-names>Robert</given-names>
</name>
<xref ref-type="aff" rid="Aff139">139</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Petrova</surname>
<given-names>Olga N.</given-names>
</name>
<address><email>olga.petrova@polytechnique.edu</email>
</address>
<xref ref-type="aff" rid="Aff144">144</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lamarre</surname>
<given-names>Isabelle</given-names>
</name>
<xref ref-type="aff" rid="Aff144">144</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Négrerie</surname>
<given-names>Michel</given-names>
</name>
<xref ref-type="aff" rid="Aff144">144</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Robinson</surname>
<given-names>Jerid W.</given-names>
</name>
<address><email>robin768@umn.edu</email>
</address>
<xref ref-type="aff" rid="Aff145">145</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Egbert</surname>
<given-names>Jeremy R.</given-names>
</name>
<xref ref-type="aff" rid="Aff146">146</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Davydova</surname>
<given-names>Julia</given-names>
</name>
<xref ref-type="aff" rid="Aff147">147</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jaffe</surname>
<given-names>Laurinda A.</given-names>
</name>
<xref ref-type="aff" rid="Aff146">146</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Potter</surname>
<given-names>Lincoln R.</given-names>
</name>
<xref ref-type="aff" rid="Aff145">145</xref>
<xref ref-type="aff" rid="Aff148">148</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Robinson</surname>
<given-names>Jerid W.</given-names>
</name>
<address><email>robin768@umn.edu</email>
</address>
<xref ref-type="aff" rid="Aff149">149</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Blixt</surname>
<given-names>Nicholas</given-names>
</name>
<xref ref-type="aff" rid="Aff150">150</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shuhaibar</surname>
<given-names>Leia C.</given-names>
</name>
<xref ref-type="aff" rid="Aff151">151</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Warren</surname>
<given-names>Gordon L.</given-names>
</name>
<xref ref-type="aff" rid="Aff152">152</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mansky</surname>
<given-names>Kim C.</given-names>
</name>
<xref ref-type="aff" rid="Aff150">150</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jaffe</surname>
<given-names>Laurinda A.</given-names>
</name>
<xref ref-type="aff" rid="Aff151">151</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Potter</surname>
<given-names>Lincoln R.</given-names>
</name>
<xref ref-type="aff" rid="Aff149">149</xref>
<xref ref-type="aff" rid="Aff153">153</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Romoli</surname>
<given-names>Simone</given-names>
</name>
<address><email>simone.romoli@bayer.com</email>
</address>
<xref ref-type="aff" rid="Aff154">154</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bauch</surname>
<given-names>Tobias</given-names>
</name>
<xref ref-type="aff" rid="Aff154">154</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dröbner</surname>
<given-names>Karoline</given-names>
</name>
<xref ref-type="aff" rid="Aff154">154</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Eitner</surname>
<given-names>Frank</given-names>
</name>
<xref ref-type="aff" rid="Aff154">154</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Ruppert</surname>
<given-names>Mihály</given-names>
</name>
<address><email>ruppertmis@gmail.com</email>
</address>
<xref ref-type="aff" rid="Aff155">155</xref>
<xref ref-type="aff" rid="Aff156">156</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Radovits</surname>
<given-names>Tamás</given-names>
</name>
<xref ref-type="aff" rid="Aff156">156</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Korkmaz-Icöz</surname>
<given-names>Sevil</given-names>
</name>
<xref ref-type="aff" rid="Aff155">155</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Shiliang</given-names>
</name>
<xref ref-type="aff" rid="Aff155">155</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hegedűs</surname>
<given-names>Péter</given-names>
</name>
<xref ref-type="aff" rid="Aff155">155</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Loganathan</surname>
<given-names>Sivakanan</given-names>
</name>
<xref ref-type="aff" rid="Aff155">155</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Németh</surname>
<given-names>Balázs Tamás</given-names>
</name>
<xref ref-type="aff" rid="Aff156">156</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Oláh</surname>
<given-names>Attila</given-names>
</name>
<xref ref-type="aff" rid="Aff156">156</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mátyás</surname>
<given-names>Csaba</given-names>
</name>
<xref ref-type="aff" rid="Aff156">156</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Benke</surname>
<given-names>Kálmán</given-names>
</name>
<xref ref-type="aff" rid="Aff156">156</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Merkely</surname>
<given-names>Béla</given-names>
</name>
<xref ref-type="aff" rid="Aff156">156</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Karck</surname>
<given-names>Matthias</given-names>
</name>
<xref ref-type="aff" rid="Aff155">155</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Szabó</surname>
<given-names>Gábor</given-names>
</name>
<xref ref-type="aff" rid="Aff155">155</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Scheib</surname>
<given-names>Ulrike</given-names>
</name>
<address><email>ulrike.scheib@hu-berlin.de</email>
</address>
<xref ref-type="aff" rid="Aff157">157</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Broser</surname>
<given-names>Matthias</given-names>
</name>
<xref ref-type="aff" rid="Aff157">157</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mukherjee</surname>
<given-names>Shatanik</given-names>
</name>
<xref ref-type="aff" rid="Aff157">157</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stehfest</surname>
<given-names>Katja</given-names>
</name>
<xref ref-type="aff" rid="Aff157">157</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gee</surname>
<given-names>Christine E.</given-names>
</name>
<xref ref-type="aff" rid="Aff158">158</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Körschen</surname>
<given-names>Heinz G.</given-names>
</name>
<xref ref-type="aff" rid="Aff159">159</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Oertner</surname>
<given-names>Thomas G.</given-names>
</name>
<xref ref-type="aff" rid="Aff158">158</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hegemann</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="Aff157">157</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Schmidt</surname>
<given-names>Hannes</given-names>
</name>
<address><email>hannes.schmidt@uni-tuebingen.de</email>
</address>
<xref ref-type="aff" rid="Aff160">160</xref>
<xref ref-type="aff" rid="Aff161">161</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dickey</surname>
<given-names>Deborah M.</given-names>
</name>
<xref ref-type="aff" rid="Aff162">162</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dumoulin</surname>
<given-names>Alexandre</given-names>
</name>
<xref ref-type="aff" rid="Aff161">161</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kühn</surname>
<given-names>Ralf</given-names>
</name>
<xref ref-type="aff" rid="Aff161">161</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jaffe</surname>
<given-names>Laurinda</given-names>
</name>
<xref ref-type="aff" rid="Aff163">163</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Potter</surname>
<given-names>Lincoln R.</given-names>
</name>
<xref ref-type="aff" rid="Aff162">162</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rathjen</surname>
<given-names>Fritz G.</given-names>
</name>
<xref ref-type="aff" rid="Aff161">161</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Schobesberger</surname>
<given-names>Sophie</given-names>
</name>
<address><email>s.schobesberger@uke.de</email>
</address>
<xref ref-type="aff" rid="Aff164">164</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wright</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="Aff165">165</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Poulet</surname>
<given-names>Claire</given-names>
</name>
<xref ref-type="aff" rid="Aff165">165</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mansfield</surname>
<given-names>Catherine</given-names>
</name>
<xref ref-type="aff" rid="Aff165">165</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Friebe</surname>
<given-names>Andreas</given-names>
</name>
<xref ref-type="aff" rid="Aff166">166</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Harding</surname>
<given-names>Sian E.</given-names>
</name>
<xref ref-type="aff" rid="Aff165">165</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nikolaev</surname>
<given-names>Viacheslav O.</given-names>
</name>
<xref ref-type="aff" rid="Aff164">164</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gorelik</surname>
<given-names>Julia</given-names>
</name>
<xref ref-type="aff" rid="Aff165">165</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kollau</surname>
<given-names>Alexander</given-names>
</name>
<xref ref-type="aff" rid="Aff167">167</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Opelt</surname>
<given-names>Marissa</given-names>
</name>
<xref ref-type="aff" rid="Aff167">167</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wölkart</surname>
<given-names>Gerald</given-names>
</name>
<xref ref-type="aff" rid="Aff167">167</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gorren</surname>
<given-names>Antonius C. F.</given-names>
</name>
<xref ref-type="aff" rid="Aff167">167</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Russwurm</surname>
<given-names>Michael</given-names>
</name>
<xref ref-type="aff" rid="Aff168">168</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Koesling</surname>
<given-names>Doris</given-names>
</name>
<xref ref-type="aff" rid="Aff168">168</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schrammel</surname>
<given-names>Astrid</given-names>
</name>
<address><email>astrid.schrammel-gorren@uni-graz.at</email>
</address>
<xref ref-type="aff" rid="Aff167">167</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mayer</surname>
<given-names>Bernd</given-names>
</name>
<xref ref-type="aff" rid="Aff167">167</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Schwaerzer</surname>
<given-names>Gerburg K.</given-names>
</name>
<address><email>gschwaerzer@ucsd.edu</email>
</address>
<xref ref-type="aff" rid="Aff169">169</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Casteel</surname>
<given-names>Darren E.</given-names>
</name>
<xref ref-type="aff" rid="Aff169">169</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dalton</surname>
<given-names>Nancy D.</given-names>
</name>
<xref ref-type="aff" rid="Aff169">169</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gu</surname>
<given-names>Yusu</given-names>
</name>
<xref ref-type="aff" rid="Aff169">169</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhuang</surname>
<given-names>Shunhui</given-names>
</name>
<xref ref-type="aff" rid="Aff169">169</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Milewicz</surname>
<given-names>Dianna M.</given-names>
</name>
<xref ref-type="aff" rid="Aff170">170</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Peterson</surname>
<given-names>Kirk L.</given-names>
</name>
<xref ref-type="aff" rid="Aff170">170</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pilz</surname>
<given-names>Renate</given-names>
</name>
<xref ref-type="aff" rid="Aff169">169</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Schwiering</surname>
<given-names>Fabian</given-names>
</name>
<address><email>fabian.schwiering@uni-wuerzburg.de</email>
</address>
<xref ref-type="aff" rid="Aff171">171</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aue</surname>
<given-names>Annemarie</given-names>
</name>
<xref ref-type="aff" rid="Aff171">171</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Groneberg</surname>
<given-names>Dieter</given-names>
</name>
<xref ref-type="aff" rid="Aff171">171</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Friebe</surname>
<given-names>Andreas</given-names>
</name>
<xref ref-type="aff" rid="Aff171">171</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Argyriou</surname>
<given-names>Aikaterini I.</given-names>
</name>
<xref ref-type="aff" rid="Aff172">172</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Makrynitsa</surname>
<given-names>Garyfalia</given-names>
</name>
<xref ref-type="aff" rid="Aff172">172</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Alexandropoulos</surname>
<given-names>Ioannis I.</given-names>
</name>
<xref ref-type="aff" rid="Aff172">172</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stamopoulou</surname>
<given-names>Andriana</given-names>
</name>
<xref ref-type="aff" rid="Aff172">172</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bantzi</surname>
<given-names>Marina</given-names>
</name>
<xref ref-type="aff" rid="Aff173">173</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Giannis</surname>
<given-names>Athanassios</given-names>
</name>
<xref ref-type="aff" rid="Aff173">173</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Topouzis</surname>
<given-names>Stavros</given-names>
</name>
<xref ref-type="aff" rid="Aff172">172</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Papapetropoulos</surname>
<given-names>Andreas</given-names>
</name>
<xref ref-type="aff" rid="Aff172">172</xref>
<xref ref-type="aff" rid="Aff174">174</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Spyroulias</surname>
<given-names>Georgios A.</given-names>
</name>
<address><email>G.A.Spyroulias@upatras.gr</email>
</address>
<xref ref-type="aff" rid="Aff172">172</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Stuehr</surname>
<given-names>Dennis J.</given-names>
</name>
<address><email>stuehrd@ccf.org</email>
</address>
<xref ref-type="aff" rid="Aff175">175</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ghosh</surname>
<given-names>Arnab</given-names>
</name>
<xref ref-type="aff" rid="Aff175">175</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dai</surname>
<given-names>Yue</given-names>
</name>
<xref ref-type="aff" rid="Aff175">175</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Misra</surname>
<given-names>Saurav</given-names>
</name>
<xref ref-type="aff" rid="Aff176">176</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Tchernychev</surname>
<given-names>Boris</given-names>
</name>
<address><email>btchernychev@ironwoodpharma.com</email>
</address>
<xref ref-type="aff" rid="Aff177">177</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jung</surname>
<given-names>Joon</given-names>
</name>
<xref ref-type="aff" rid="Aff177">177</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Liu</surname>
<given-names>Guang</given-names>
</name>
<xref ref-type="aff" rid="Aff177">177</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Silos-Santiago</surname>
<given-names>Inmaculada</given-names>
</name>
<xref ref-type="aff" rid="Aff178">178</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hannig</surname>
<given-names>Gerhard</given-names>
</name>
<xref ref-type="aff" rid="Aff177">177</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dao</surname>
<given-names>Vu Thao-Vi</given-names>
</name>
<xref ref-type="aff" rid="Aff179">179</xref>
<xref ref-type="aff" rid="Aff180">180</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Deile</surname>
<given-names>Martin</given-names>
</name>
<xref ref-type="aff" rid="Aff181">181</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nedvetsky</surname>
<given-names>Pavel I.</given-names>
</name>
<xref ref-type="aff" rid="Aff182">182</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Güldner</surname>
<given-names>Andreas</given-names>
</name>
<xref ref-type="aff" rid="Aff183">183</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ibarra-Alvarado</surname>
<given-names>César</given-names>
</name>
<xref ref-type="aff" rid="Aff184">184</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gödecke</surname>
<given-names>Axel</given-names>
</name>
<xref ref-type="aff" rid="Aff185">185</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Schmidt</surname>
<given-names>Harald H. H. W.</given-names>
</name>
<address><email>h.schmidt@maastrichtuniversity.nl</email>
</address>
<xref ref-type="aff" rid="Aff179">179</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Vachaviolos</surname>
<given-names>Angelos</given-names>
</name>
<address><email>angelos.vachaviolos@uni-tuebingen.de</email>
</address>
<xref ref-type="aff" rid="Aff186">186</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gerling</surname>
<given-names>Andrea</given-names>
</name>
<xref ref-type="aff" rid="Aff186">186</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Thunemann</surname>
<given-names>Martin</given-names>
</name>
<xref ref-type="aff" rid="Aff186">186</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lutz</surname>
<given-names>Stefan Z.</given-names>
</name>
<xref ref-type="aff" rid="Aff187">187</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Häring</surname>
<given-names>Hans-Ulrich</given-names>
</name>
<xref ref-type="aff" rid="Aff187">187</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Krüger</surname>
<given-names>Marcel A.</given-names>
</name>
<xref ref-type="aff" rid="Aff188">188</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pichler</surname>
<given-names>Bernd J.</given-names>
</name>
<xref ref-type="aff" rid="Aff188">188</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shipston</surname>
<given-names>Michael J.</given-names>
</name>
<xref ref-type="aff" rid="Aff189">189</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Feil</surname>
<given-names>Susanne</given-names>
</name>
<xref ref-type="aff" rid="Aff186">186</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Feil</surname>
<given-names>Robert</given-names>
</name>
<xref ref-type="aff" rid="Aff186">186</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Vandenwijngaert</surname>
<given-names>Sara</given-names>
</name>
<address><email>svandenwijngaert@mgh.harvard.edu</email>
</address>
<xref ref-type="aff" rid="Aff190">190</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ledsky</surname>
<given-names>Clara D.</given-names>
</name>
<xref ref-type="aff" rid="Aff190">190</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Agha</surname>
<given-names>Obiajulu</given-names>
</name>
<xref ref-type="aff" rid="Aff190">190</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hu</surname>
<given-names>Dongjian</given-names>
</name>
<xref ref-type="aff" rid="Aff191">191</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Domian</surname>
<given-names>Ibrahim J.</given-names>
</name>
<xref ref-type="aff" rid="Aff191">191</xref>
<xref ref-type="aff" rid="Aff192">192</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Buys</surname>
<given-names>Emmanuel S.</given-names>
</name>
<xref ref-type="aff" rid="Aff190">190</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Newton-Cheh</surname>
<given-names>Christopher</given-names>
</name>
<xref ref-type="aff" rid="Aff191">191</xref>
<xref ref-type="aff" rid="Aff193">193</xref>
<xref ref-type="aff" rid="Aff194">194</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bloch</surname>
<given-names>Donald B.</given-names>
</name>
<xref ref-type="aff" rid="Aff190">190</xref>
<xref ref-type="aff" rid="Aff195">195</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Voussen</surname>
<given-names>Barbara</given-names>
</name>
<address><email>barbara.voussen@uni-wuerzburg.de</email>
</address>
<xref ref-type="aff" rid="Aff196">196</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Beck</surname>
<given-names>Katharina</given-names>
</name>
<xref ref-type="aff" rid="Aff196">196</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mauro</surname>
<given-names>Nadine</given-names>
</name>
<xref ref-type="aff" rid="Aff196">196</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Keppler</surname>
<given-names>Jonas</given-names>
</name>
<xref ref-type="aff" rid="Aff196">196</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Friebe</surname>
<given-names>Andreas</given-names>
</name>
<xref ref-type="aff" rid="Aff196">196</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Ferreira</surname>
<given-names>Wilson A.</given-names>
<suffix>Jr</suffix>
</name>
<address><email>ferreirajr@usp.br</email>
</address>
<xref ref-type="aff" rid="Aff197">197</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chweih</surname>
<given-names>Hanan</given-names>
</name>
<xref ref-type="aff" rid="Aff197">197</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brito</surname>
<given-names>Pamela L.</given-names>
</name>
<xref ref-type="aff" rid="Aff197">197</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Almeida</surname>
<given-names>Camila B.</given-names>
</name>
<xref ref-type="aff" rid="Aff197">197</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Penteado</surname>
<given-names>Carla F. F.</given-names>
</name>
<xref ref-type="aff" rid="Aff197">197</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Saad</surname>
<given-names>Sara S. O.</given-names>
</name>
<xref ref-type="aff" rid="Aff197">197</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Costa</surname>
<given-names>Fernando F.</given-names>
</name>
<xref ref-type="aff" rid="Aff197">197</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Frenette</surname>
<given-names>Paul S.</given-names>
</name>
<xref ref-type="aff" rid="Aff199">199</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brockschnieder</surname>
<given-names>Damian</given-names>
</name>
<xref ref-type="aff" rid="Aff198">198</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stasch</surname>
<given-names>Johannes-Peter</given-names>
</name>
<xref ref-type="aff" rid="Aff198">198</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sandner</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="Aff198">198</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Conran</surname>
<given-names>Nicola</given-names>
</name>
<xref ref-type="aff" rid="Aff197">197</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Zimmer</surname>
<given-names>Daniel P.</given-names>
</name>
<address><email>dzimmer@ironwoodpharma.com</email>
</address>
<xref ref-type="aff" rid="Aff200">200</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tobin</surname>
<given-names>Jenny</given-names>
</name>
<xref ref-type="aff" rid="Aff200">200</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shea</surname>
<given-names>Courtney</given-names>
</name>
<xref ref-type="aff" rid="Aff200">200</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sarno</surname>
<given-names>Renee</given-names>
</name>
<xref ref-type="aff" rid="Aff200">200</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Long</surname>
<given-names>Kimberly</given-names>
</name>
<xref ref-type="aff" rid="Aff200">200</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jacobson</surname>
<given-names>Sarah</given-names>
</name>
<xref ref-type="aff" rid="Aff200">200</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tang</surname>
<given-names>Kim</given-names>
</name>
<xref ref-type="aff" rid="Aff200">200</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Germano</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="Aff200">200</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wakefield</surname>
<given-names>James</given-names>
</name>
<xref ref-type="aff" rid="Aff200">200</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Banijamali</surname>
<given-names>Ali</given-names>
</name>
<xref ref-type="aff" rid="Aff200">200</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Im</surname>
<given-names>G-Yoon Jamie</given-names>
</name>
<xref ref-type="aff" rid="Aff200">200</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sheppeck</surname>
<given-names>James E.</given-names>
<suffix>II</suffix>
</name>
<xref ref-type="aff" rid="Aff200">200</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Profy</surname>
<given-names>Albert T.</given-names>
</name>
<xref ref-type="aff" rid="Aff200">200</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Todd Milne</surname>
<given-names>G.</given-names>
</name>
<xref ref-type="aff" rid="Aff200">200</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Currie</surname>
<given-names>Mark G.</given-names>
</name>
<xref ref-type="aff" rid="Aff200">200</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Masferrer</surname>
<given-names>Jaime L.</given-names>
</name>
<xref ref-type="aff" rid="Aff200">200</xref>
</contrib>
<aff id="Aff1"><label>1</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</aff>
<aff id="Aff2"><label>2</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Bayer AG, Drug Discovery - Cardiovascular Research,</institution>
</institution-wrap>
Wuppertal, Germany</aff>
<aff id="Aff3"><label>3</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1312 9717</institution-id>
<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals,</institution>
</institution-wrap>
Ridgefield, CT USA</aff>
<aff id="Aff4"><label>4</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1312 9717</institution-id>
<institution-id institution-id-type="GRID">grid.418412.a</institution-id>
<institution>Department of Small Molecule Drug Research, Boehringer Ingelheim Pharmaceuticals,</institution>
</institution-wrap>
Ridgefield, CT USA</aff>
<aff id="Aff5"><label>5</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</aff>
<aff id="Aff6"><label>6</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Institute of Experimental Medical Research,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</aff>
<aff id="Aff7"><label>7</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</aff>
<aff id="Aff8"><label>8</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Pharmacology, Toxicology and Clinical Pharmacy,</institution>
<institution>Institute of Pharmacy, University of Tuebingen,</institution>
</institution-wrap>
Tuebingen, Germany</aff>
<aff id="Aff9"><label>9</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</aff>
<aff id="Aff10"><label>10</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8934 4045</institution-id>
<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Molecular Cardiology Research Institute, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</aff>
<aff id="Aff11"><label>11</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0650 7433</institution-id>
<institution-id institution-id-type="GRID">grid.412689.0</institution-id>
<institution>Present Affiliation: Division of Cardiology,</institution>
<institution>University of Pittsburgh Medical Center,</institution>
</institution-wrap>
Pittsburgh, Pennsylvania ,15224 USA</aff>
<aff id="Aff12"><label>12</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9094</institution-id>
<institution-id institution-id-type="GRID">grid.40263.33</institution-id>
<institution>Present Affiliation: Department of Medicine,</institution>
<institution>Brown University School of Medicine,</institution>
</institution-wrap>
Providence, Rhode Island ,02912 USA</aff>
<aff id="Aff13"><label>13</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8934 4045</institution-id>
<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Division of Cardiology, Tufts Medical Center,</institution>
</institution-wrap>
Boston, Massachusetts 02111 USA</aff>
<aff id="Aff14"><label>14</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2104 4211</institution-id>
<institution-id institution-id-type="GRID">grid.418140.8</institution-id>
<institution>Max Planck Institute for Biophysical Chemistry, Göttingen and German Cancer Research Center (DKFZ),</institution>
</institution-wrap>
Heidelberg, Germany</aff>
<aff id="Aff15"><label>15</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2166 5843</institution-id>
<institution-id institution-id-type="GRID">grid.265008.9</institution-id>
<institution>Department of Pharmacology and Experimental Therapeutics,</institution>
<institution>Thomas Jefferson University,</institution>
</institution-wrap>
Philadelphia, Pennsylvania 19107 USA</aff>
<aff id="Aff16"><label>16</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0057 2672</institution-id>
<institution-id institution-id-type="GRID">grid.4562.5</institution-id>
<institution>Institut für Kardiogenetik and Universitäres Herzzentrum Lübeck, Universität zu Lübeck, Lübeck, Germany & DZHK e.V. (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck,</institution>
</institution-wrap>
Lübeck, Germany</aff>
<aff id="Aff17"><label>17</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000000123222966</institution-id>
<institution-id institution-id-type="GRID">grid.6936.a</institution-id>
<institution>Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen,</institution>
<institution>Technische Universität München,</institution>
</institution-wrap>
Munich, Germany</aff>
<aff id="Aff18"><label>18</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1941 7111</institution-id>
<institution-id institution-id-type="GRID">grid.5802.f</institution-id>
<institution>Center for Thrombosis & Hemostasis,</institution>
<institution>Universitätsklinikum der Johannes Gutenberg-Universität Mainz,</institution>
</institution-wrap>
Mainz, Germany</aff>
<aff id="Aff19"><label>19</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0492 9407</institution-id>
<institution-id institution-id-type="GRID">grid.419243.9</institution-id>
<institution>Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V,</institution>
</institution-wrap>
Dortmund, Germany</aff>
<aff id="Aff20"><label>20</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0440 2269</institution-id>
<institution-id institution-id-type="GRID">grid.419730.8</institution-id>
<institution>Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences,</institution>
</institution-wrap>
St. Petersburg, Russia</aff>
<aff id="Aff21"><label>21</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0768 2743</institution-id>
<institution-id institution-id-type="GRID">grid.7886.1</institution-id>
<institution>UCD Conway Institute, UCD School of Medicine and Medical Science,</institution>
<institution>University College Dublin,</institution>
</institution-wrap>
Dublin, Ireland</aff>
<aff id="Aff22"><label>22</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9094</institution-id>
<institution-id institution-id-type="GRID">grid.40263.33</institution-id>
<institution>Division of Pulmonary, Sleep and Critical Care Medicine, Rhode Island Hospital,</institution>
<institution>Alpert Medical School of Brown University,</institution>
</institution-wrap>
Providence, RI USA</aff>
<aff id="Aff23"><label>23</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0455 1168</institution-id>
<institution-id institution-id-type="GRID">grid.413621.3</institution-id>
<institution>Cardiovascular Institute, Allegheny General Hospital,</institution>
</institution-wrap>
Pittsburgh, PA USA</aff>
<aff id="Aff24"><label>24</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0462 7212</institution-id>
<institution-id institution-id-type="GRID">grid.1006.7</institution-id>
<institution>Institute of Cellular Medicine,</institution>
<institution>Newcastle University,</institution>
</institution-wrap>
Newcastle, UK</aff>
<aff id="Aff25"><label>25</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8649</institution-id>
<institution-id institution-id-type="GRID">grid.14709.3b</institution-id>
<institution>Center for Pulmonary Vascular Disease and Lady Davis Institute, Jewish General Hospital,</institution>
<institution>McGill University,</institution>
</institution-wrap>
Montreal, QC Canada</aff>
<aff id="Aff26"><label>26</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8571 829X</institution-id>
<institution-id institution-id-type="GRID">grid.412157.4</institution-id>
<institution>Department of Cardiology,</institution>
<institution>Erasme University Hospital,</institution>
</institution-wrap>
Brussels, Belgium</aff>
<aff id="Aff27"><label>27</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 2558</institution-id>
<institution-id institution-id-type="GRID">grid.5842.b</institution-id>
<institution>Assistance Publique–Hôpitaux de Paris, Service de Pneumologie, Hôpital Bicêtre,</institution>
<institution>Université Paris-Sud, Laboratoire d’Excellence en Recherche sur le Médicament et Innovation Thérapeutique, and INSERM Unité 999,</institution>
</institution-wrap>
Le Kremlin–Bicêtre, France</aff>
<aff id="Aff28"><label>28</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Global Clinical Development, Bayer AG,</institution>
</institution-wrap>
Berlin, Germany</aff>
<aff id="Aff29"><label>29</label>
Global Clinical Development, Bayer HealthCare Pharmaceuticals, Barcelona, Spain</aff>
<aff id="Aff30"><label>30</label>
Chrestos Concept GmbH & Co, Essen, Germany</aff>
<aff id="Aff31"><label>31</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9529 9877</institution-id>
<institution-id institution-id-type="GRID">grid.10423.34</institution-id>
<institution>Clinic for Respiratory Medicine, Hannover Medical School,</institution>
</institution-wrap>
Hannover, Germany</aff>
<aff id="Aff32"><label>32</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</aff>
<aff id="Aff33"><label>33</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9635 9413</institution-id>
<institution-id institution-id-type="GRID">grid.410458.c</institution-id>
<institution>Department of Biochemistry and Molecular Genetics,</institution>
<institution>Hospital Clinic-University of Barcelona,</institution>
</institution-wrap>
Barcelona, Spain</aff>
<aff id="Aff34"><label>34</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Elfriede-Aulhorn-Straße 5, 72076 Tübingen, Germany</aff>
<aff id="Aff35"><label>35</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfaculty Institute of Biochemistry,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Hoppe-Seyler-Straße 4, 72076 Tübingen, Germany</aff>
<aff id="Aff36"><label>36</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Bochum, Universitätsstr 150,</institution>
</institution-wrap>
44780 Bochum, Germany</aff>
<aff id="Aff37"><label>37</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Auf der Morgenstelle 8, 72076 Tübingen, Germany</aff>
<aff id="Aff38"><label>38</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Department of Physiology,</institution>
<institution>University of Würzburg,</institution>
</institution-wrap>
Röntgenring 9, 97070 Würzburg, Germany</aff>
<aff id="Aff39"><label>39</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</aff>
<aff id="Aff40"><label>40</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0373 3971</institution-id>
<institution-id institution-id-type="GRID">grid.136593.b</institution-id>
<institution>Department of General Thoracic Surgery,</institution>
<institution>Osaka University Graduate School of Medicine,</institution>
</institution-wrap>
Suita, Osaka, Japan</aff>
<aff id="Aff41"><label>41</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</aff>
<aff id="Aff42"><label>42</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, Barts & The London School of Medicine, QMUL,</institution>
</institution-wrap>
London, UK</aff>
<aff id="Aff43"><label>43</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 9311</institution-id>
<institution-id institution-id-type="GRID">grid.21107.35</institution-id>
<institution>Division of Cardiology, Department of Medicine,</institution>
<institution>Johns Hopkins Medical Institutions,</institution>
</institution-wrap>
Baltimore, Maryland USA</aff>
<aff id="Aff44"><label>44</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1757 3630</institution-id>
<institution-id institution-id-type="GRID">grid.9027.c</institution-id>
<institution>Department of Experimental Medicine,</institution>
<institution>University of Perugia,</institution>
</institution-wrap>
06123 Perugia, Italy</aff>
<aff id="Aff45"><label>45</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>King’s College London, Cardiovascular Division, The Rayne Institute,</institution>
</institution-wrap>
St Thomas’ Hospital, London, UK</aff>
<aff id="Aff46"><label>46</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Structural and Computational Biology and Molecular Biophysics Program,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, TX USA</aff>
<aff id="Aff47"><label>47</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, TX USA</aff>
<aff id="Aff48"><label>48</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1089 1036</institution-id>
<institution-id institution-id-type="GRID">grid.5155.4</institution-id>
<institution>Department of Biochemistry,</institution>
<institution>University of Kassel,</institution>
</institution-wrap>
Kassel, Hesse Germany</aff>
<aff id="Aff49"><label>49</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2231 4551</institution-id>
<institution-id institution-id-type="GRID">grid.184769.5</institution-id>
<institution>Berkeley Center for Structural Biology, Lawrence Berkeley National Laboratory,</institution>
</institution-wrap>
Berkeley, CA USA</aff>
<aff id="Aff50"><label>50</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Verna and Marrs McLean Department of Biochemistry and Molecular Biology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, TX USA</aff>
<aff id="Aff51"><label>51</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000000123222966</institution-id>
<institution-id institution-id-type="GRID">grid.6936.a</institution-id>
<institution>Technische Universität München, Department of Chemistry, Biomolecular NMR Spectroscopy,</institution>
</institution-wrap>
Garching, Germany</aff>
<aff id="Aff52"><label>52</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000000123222966</institution-id>
<institution-id institution-id-type="GRID">grid.6936.a</institution-id>
<institution>Technische Universität München, Department of Chemistry, Computational Biocatalysis,</institution>
</institution-wrap>
Garching, Germany</aff>
<aff id="Aff53"><label>53</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0483 2525</institution-id>
<institution-id institution-id-type="GRID">grid.4567.0</institution-id>
<institution>Institute of Structural Biology, Helmholtz Zentrum München,</institution>
</institution-wrap>
Neuherberg, Germany</aff>
<aff id="Aff54"><label>54</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2193 314X</institution-id>
<institution-id institution-id-type="GRID">grid.8756.c</institution-id>
<institution>Institute of Molecular Cell and Systems Biology,</institution>
<institution>University of Glasgow,</institution>
</institution-wrap>
Glasgow, UK</aff>
<aff id="Aff55"><label>55</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>BHF Centre of Research Excellence, King’s College London,</institution>
</institution-wrap>
London, SE1 7EH UK</aff>
<aff id="Aff56"><label>56</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Core Facility for Mouse Pathology,</institution>
<institution>University Medical Centre Hamburg-Eppendorf,</institution>
</institution-wrap>
20246 Hamburg, Germany</aff>
<aff id="Aff57"><label>57</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2113 8111</institution-id>
<institution-id institution-id-type="GRID">grid.7445.2</institution-id>
<institution>Faculty of Medicine, Department of Medicine, Imperial College London,</institution>
</institution-wrap>
London, SW7 2AZ UK</aff>
<aff id="Aff58"><label>58</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2165 8627</institution-id>
<institution-id institution-id-type="GRID">grid.8664.c</institution-id>
<institution>Excellence Cluster Cardio-Pulmonary System,</institution>
<institution>Universities of Giessen and Marburg Lung Centre Member of the German Lung Canter Justus-Liebig-University Giessen,</institution>
</institution-wrap>
Giessen, Germany</aff>
<aff id="Aff59"><label>59</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, Barts & The London School of Medicine, QMUL,</institution>
</institution-wrap>
London, UK</aff>
<aff id="Aff60"><label>60</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 973X</institution-id>
<institution-id institution-id-type="GRID">grid.5252.0</institution-id>
<institution>Center for Integrated Protein Science Munich CiPSM at the Department of Pharmacy – Center for Drug Research,</institution>
<institution>Ludwig-Maximilians-Universität München,</institution>
</institution-wrap>
Munich, Germany</aff>
<aff id="Aff61"><label>61</label>
Institute for Ophthalmic Research, Centre for OphthalmologyUniversity of Tübingen, Tübingen, Germany</aff>
<aff id="Aff62"><label>62</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>University Eye Hospital, Centre for Ophthalmology Tübingen,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</aff>
<aff id="Aff63"><label>63</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>STZ eyetrial at the Centre for Ophthalmology,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</aff>
<aff id="Aff64"><label>64</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 9311</institution-id>
<institution-id institution-id-type="GRID">grid.21107.35</institution-id>
<institution>Division of Cardiology,</institution>
<institution>Johns Hopkins Medical Institutions,</institution>
</institution-wrap>
Baltimore, MD 21205 USA</aff>
<aff id="Aff65"><label>65</label>
Heart Institute and Advanced Clinical Biosystems Research Institute, Cedar Sinai Medical Center, 8700 Beverly Blvd, AHSP A9229, Los Angeles, California 90048 USA</aff>
<aff id="Aff66"><label>66</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000000122483208</institution-id>
<institution-id institution-id-type="GRID">grid.10698.36</institution-id>
<institution>McAllister Heart Institute, Division of Cardiology, UNC,</institution>
</institution-wrap>
Chapel Hill, NC USA</aff>
<aff id="Aff67"><label>67</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2195 6763</institution-id>
<institution-id institution-id-type="GRID">grid.259956.4</institution-id>
<institution>Department of Chemistry and Biochemistry,</institution>
<institution>Miami University,</institution>
</institution-wrap>
Oxford, OH 45056 USA</aff>
<aff id="Aff68"><label>68</label>
Department of Pyhisology, Anatomy and GeneticsUniversity of Oxford, Oxford, UK</aff>
<aff id="Aff69"><label>69</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Institute for Pharmacology and Toxicology, Medical Faculty,</institution>
<institution>Ruhr-University Bochum,</institution>
</institution-wrap>
44780 Bochum, Germany</aff>
<aff id="Aff70"><label>70</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1956 2722</institution-id>
<institution-id institution-id-type="GRID">grid.7048.b</institution-id>
<institution>Department of Molecular Biology and Genetics - Molecular Cell and Developmental Biology,</institution>
<institution>Aarhus University,</institution>
</institution-wrap>
C.F. Møllers Allé 3, 8000 Aarhus C, Denmark</aff>
<aff id="Aff71"><label>71</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Institute of Experimental Cardiovascular Research, Center for Experimental Medicine,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Hamburg, Germany</aff>
<aff id="Aff72"><label>72</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.440820.a</institution-id>
<institution>Computational Biochemistry and Biophysics Laboratory (CBBL), U_ScienceTech (UST),</institution>
<institution>University of Vic - Central University of Catalonia (UVIC-UCC),</institution>
</institution-wrap>
Vic, Barcelona Spain</aff>
<aff id="Aff73"><label>73</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</aff>
<aff id="Aff74"><label>74</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</aff>
<aff id="Aff75"><label>75</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Department of Physiology, Anatomy and Genetics,</institution>
<institution>Oxford University,</institution>
</institution-wrap>
Oxford, UK</aff>
<aff id="Aff76"><label>76</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>German Center for Cardiovascular Research,</institution>
<institution>University Medical Center Hamburg-Eppendorf and Institute of Experimental Cardiovascular Research,</institution>
</institution-wrap>
Hamburg, Germany</aff>
<aff id="Aff77"><label>77</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</aff>
<aff id="Aff78"><label>78</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 4373</institution-id>
<institution-id institution-id-type="GRID">grid.7700.0</institution-id>
<institution>Department of Clinical Pharmacology and Pharmacoepidemiology,</institution>
<institution>University of Heidelberg,</institution>
</institution-wrap>
Im Neuenheimer Feld 410, 69120 Heidelberg, Germany</aff>
<aff id="Aff79"><label>79</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</aff>
<aff id="Aff80"><label>80</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8227</institution-id>
<institution-id institution-id-type="GRID">grid.25073.33</institution-id>
<institution>Farncombe Family Digestive Health Research Institute,</institution>
<institution>McMaster University,</institution>
</institution-wrap>
Hamilton, Canada</aff>
<aff id="Aff81"><label>81</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9510</institution-id>
<institution-id institution-id-type="GRID">grid.253615.6</institution-id>
<institution>Department of Biochemistry and Molecular Medicine,</institution>
<institution>George Washington University, School of Medicine,</institution>
</institution-wrap>
Washington, DC USA</aff>
<aff id="Aff82"><label>82</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0723 2494</institution-id>
<institution-id institution-id-type="GRID">grid.411087.b</institution-id>
<institution>Department of Pharmacology, Faculty of Medical Sciences,</institution>
<institution>State University of Campinas (UNICAMP),</institution>
</institution-wrap>
Campinas, Sao Paolo Brazil</aff>
<aff id="Aff83"><label>83</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>King’s College London, Cardiovascular Division, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas’ Hospital,</institution>
</institution-wrap>
London, SE1 7EH UK</aff>
<aff id="Aff84"><label>84</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</aff>
<aff id="Aff85"><label>85</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</aff>
<aff id="Aff86"><label>86</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, Texas USA</aff>
<aff id="Aff87"><label>87</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center,</institution>
<institution>University, Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</aff>
<aff id="Aff88"><label>88</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</aff>
<aff id="Aff89"><label>89</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0057 2672</institution-id>
<institution-id institution-id-type="GRID">grid.4562.5</institution-id>
<institution>Department of Physiology,</institution>
<institution>University of Lübeck, DZHK Partner Site Hamburg/Kiel/Lübeck, University Heart Centre Lübeck,</institution>
</institution-wrap>
Lübeck, Germany</aff>
<aff id="Aff90"><label>90</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Hoppe-Seyler-Str. 4, 72076 Tübingen, Germany</aff>
<aff id="Aff91"><label>91</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 6764</institution-id>
<institution-id institution-id-type="GRID">grid.13097.3c</institution-id>
<institution>King’s College London, Cardiovascular Division, British Heart Foundation Centre of Excellence,</institution>
<institution>the Rayne Institute, St Thomas´ Hospital,</institution>
</institution-wrap>
SE17EH, London, UK</aff>
<aff id="Aff92"><label>92</label>
Institute of Experimental Biomedicine II, University Medical Center Würzburg, Grombühlstraße 12, 97080 Würzburg, Germany</aff>
<aff id="Aff93"><label>93</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Institute of Experimental Cardiovascular Research,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
</institution-wrap>
Martinistrasse 52, 20246 Hamburg, Germany</aff>
<aff id="Aff94"><label>94</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2185 3318</institution-id>
<institution-id institution-id-type="GRID">grid.241167.7</institution-id>
<institution>Department of Chemistry,</institution>
<institution>Wake Forest University,</institution>
</institution-wrap>
Winston-Salem, North Carolina 27109 USA</aff>
<aff id="Aff95"><label>95</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Institute of Biochemistry and Pathobiochemistry - Microbial Biochemistry,</institution>
<institution>Ruhr University Bochum,</institution>
</institution-wrap>
Universitätsstrasse 150, 44780 Bochum, Germany</aff>
<aff id="Aff96"><label>96</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</aff>
<aff id="Aff97"><label>97</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>Universität Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</aff>
<aff id="Aff98"><label>98</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0057 2672</institution-id>
<institution-id institution-id-type="GRID">grid.4562.5</institution-id>
<institution>Institut für Physiologie,</institution>
<institution>Universität zu Lübeck,</institution>
</institution-wrap>
Lübeck, Germany</aff>
<aff id="Aff99"><label>99</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Cardiology & Cardiovascular Medicine,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</aff>
<aff id="Aff100"><label>100</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</aff>
<aff id="Aff101"><label>101</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1089 1036</institution-id>
<institution-id institution-id-type="GRID">grid.5155.4</institution-id>
<institution>Department of Biochemistry,</institution>
<institution>University of Kassel,</institution>
</institution-wrap>
34132 Kassel, Germany</aff>
<aff id="Aff102"><label>102</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
One Baylor Plaza, Houston, Texas USA</aff>
<aff id="Aff103"><label>103</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.440517.3</institution-id>
<institution>Department of Internal Medicine,</institution>
<institution>University of Giessen and Marburg Lung Center (UGMLC),</institution>
</institution-wrap>
Giessen, Germany</aff>
<aff id="Aff104"><label>104</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0328 4908</institution-id>
<institution-id institution-id-type="GRID">grid.5253.1</institution-id>
<institution>Centre for Pulmonary Hypertension at the Thoraxclinic of University Hospital Heidelberg,</institution>
</institution-wrap>
Heidelberg, Germany</aff>
<aff id="Aff105"><label>105</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1760 3705</institution-id>
<institution-id institution-id-type="GRID">grid.413352.2</institution-id>
<institution>Department of Cardiology, Guangdong General Hospital and Guangdong Cardiovascular Institute,</institution>
</institution-wrap>
Guangzhou, Guangdong China</aff>
<aff id="Aff106"><label>106</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9100 9940</institution-id>
<institution-id institution-id-type="GRID">grid.411798.2</institution-id>
<institution>Department of Cardiology and Angiology of the First Faculty of Medicine and General Teaching Hospital,</institution>
</institution-wrap>
Prague, Czech Republic</aff>
<aff id="Aff107"><label>107</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0662 3178</institution-id>
<institution-id institution-id-type="GRID">grid.12527.33</institution-id>
<institution>State Key Laboratory of Cardiovascular Disease FuWai Hospital, National Center for Cardiovascular DiseasePeking Union Medical College and Chinese Academy of Medical Sciences,</institution>
</institution-wrap>
Beijing, China</aff>
<aff id="Aff108"><label>108</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 826X</institution-id>
<institution-id institution-id-type="GRID">grid.1009.8</institution-id>
<institution>Discipline of Medicine,</institution>
<institution>University of Tasmania,</institution>
</institution-wrap>
Hobart, Australia</aff>
<aff id="Aff109"><label>109</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8649</institution-id>
<institution-id institution-id-type="GRID">grid.14709.3b</institution-id>
<institution>Center for Pulmonary Vascular Disease,</institution>
<institution>McGill University,</institution>
</institution-wrap>
Montreal, QC Canada</aff>
<aff id="Aff110"><label>110</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8580 3777</institution-id>
<institution-id institution-id-type="GRID">grid.6190.e</institution-id>
<institution>Department III of Internal Medicine and Cologne Cardiovascular Research Centre,</institution>
<institution>Cologne University Heart Centre,</institution>
</institution-wrap>
Cologne, Germany</aff>
<aff id="Aff111"><label>111</label>
Bayer HealthCare Pharmaceuticals, São Paulo, Brazil</aff>
<aff id="Aff112"><label>112</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Global Clinical Development, Bayer AG,</institution>
</institution-wrap>
Wuppertal, Germany</aff>
<aff id="Aff113"><label>113</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Global Clinical Development, Bayer AG,</institution>
</institution-wrap>
Berlin, Germany</aff>
<aff id="Aff114"><label>114</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 4910 6535</institution-id>
<institution-id institution-id-type="GRID">grid.460789.4</institution-id>
<institution>Université Paris-Sud,</institution>
<institution>Université Paris-Saclay,</institution>
</institution-wrap>
Le Kremlin Bicêtre, France</aff>
<aff id="Aff115"><label>115</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</aff>
<aff id="Aff116"><label>116</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 5763</institution-id>
<institution-id institution-id-type="GRID">grid.7727.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Regensburg,</institution>
</institution-wrap>
93053 Regensburg, Germany</aff>
<aff id="Aff117"><label>117</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 5763</institution-id>
<institution-id institution-id-type="GRID">grid.7727.5</institution-id>
<institution>Department Functional Genomics,</institution>
<institution>University of Regensburg,</institution>
</institution-wrap>
93053 Regensburg, Germany</aff>
<aff id="Aff118"><label>118</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
</institution-wrap>
Cambridge, MA 02142 USA</aff>
<aff id="Aff119"><label>119</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2168 186X</institution-id>
<institution-id institution-id-type="GRID">grid.134563.6</institution-id>
<institution>Department of Chemistry and Biochemistry,</institution>
<institution>University of Arizona,</institution>
</institution-wrap>
Tucson, AZ 8572 USA</aff>
<aff id="Aff120"><label>120</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Verna and Marrs McLean Department of Biochemistry and Molecular Biology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, Texas USA</aff>
<aff id="Aff121"><label>121</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0448 6255</institution-id>
<institution-id institution-id-type="GRID">grid.414627.2</institution-id>
<institution>Geisinger Commonwealth School of Medicine, Commonwealth Medical College,</institution>
</institution-wrap>
Scranton, PA 18509 USA</aff>
<aff id="Aff122"><label>122</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2181 7878</institution-id>
<institution-id institution-id-type="GRID">grid.47840.3f</institution-id>
<institution>Department of Medicine,</institution>
<institution>University of California,</institution>
</institution-wrap>
San Diego, La Jolla, California, USA</aff>
<aff id="Aff123"><label>123</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id>
<institution-id institution-id-type="GRID">grid.39382.33</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>Baylor College of Medicine,</institution>
</institution-wrap>
Houston, Texas USA</aff>
<aff id="Aff124"><label>124</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000000121539003</institution-id>
<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
A 8010, Graz, Austria</aff>
<aff id="Aff125"><label>125</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>Ruhr University Bochum,</institution>
</institution-wrap>
D 44780 Bochum, Germany</aff>
<aff id="Aff126"><label>126</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2242 4849</institution-id>
<institution-id institution-id-type="GRID">grid.177174.3</institution-id>
<institution>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture,</institution>
<institution>Kyushu University,</institution>
</institution-wrap>
6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581 Japan</aff>
<aff id="Aff127"><label>127</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
5-7-1 Fujishiro-dai, Suita-City, Osaka 565-8565 Japan</aff>
<aff id="Aff128"><label>128</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000000121539003</institution-id>
<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Institute of Pharmaceutical Sciences, Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
Graz, Austria</aff>
<aff id="Aff129"><label>129</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8988 2476</institution-id>
<institution-id institution-id-type="GRID">grid.11598.34</institution-id>
<institution>Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine,</institution>
<institution>Medical University of Graz,</institution>
</institution-wrap>
Graz, Austria</aff>
<aff id="Aff130"><label>130</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>Ruhr University Bochum,</institution>
</institution-wrap>
Bochum, Germany</aff>
<aff id="Aff131"><label>131</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Department of Pharmacology, Faculty of Medicine,</institution>
<institution>University of Oslo and Oslo University Hospital,</institution>
</institution-wrap>
Oslo, Norway</aff>
<aff id="Aff132"><label>132</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8921</institution-id>
<institution-id institution-id-type="GRID">grid.5510.1</institution-id>
<institution>Center for Heart Failure Research, Faculty of Medicine,</institution>
<institution>University of Oslo,</institution>
</institution-wrap>
Oslo, Norway</aff>
<aff id="Aff133"><label>133</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7443</institution-id>
<institution-id institution-id-type="GRID">grid.7914.b</institution-id>
<institution>Department of Biomedicine, Faculty of Medicine and Dentistry,</institution>
<institution>University of Bergen,</institution>
</institution-wrap>
Bergen, Norway</aff>
<aff id="Aff134"><label>134</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</aff>
<aff id="Aff135"><label>135</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0373 3971</institution-id>
<institution-id institution-id-type="GRID">grid.136593.b</institution-id>
<institution>Department of General Thoracic Surgery,</institution>
<institution>Osaka University Graduate School of Medicine,</institution>
</institution-wrap>
Suita, Osaka, Japan</aff>
<aff id="Aff136"><label>136</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 1583</institution-id>
<institution-id institution-id-type="GRID">grid.418163.9</institution-id>
<institution>Advanced Telecommunications Research Institute International (ATR), The Thomas N. Sato BioMEC-X Laboratories,</institution>
</institution-wrap>
Kyoto, Japan</aff>
<aff id="Aff137"><label>137</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2151 536X</institution-id>
<institution-id institution-id-type="GRID">grid.26999.3d</institution-id>
<institution>The University of Tokyo, graduate school of frontier science,</institution>
</institution-wrap>
Kashiwa, Japan</aff>
<aff id="Aff138"><label>138</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0378 8307</institution-id>
<institution-id institution-id-type="GRID">grid.410796.d</institution-id>
<institution>Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center Research Institute,</institution>
</institution-wrap>
Suita, Osaka, Japan</aff>
<aff id="Aff139"><label>139</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</aff>
<aff id="Aff140"><label>140</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1014 0849</institution-id>
<institution-id institution-id-type="GRID">grid.419491.0</institution-id>
<institution>Max-Delbrück-Centrum für Molekulare Medizin,</institution>
</institution-wrap>
Berlin, Germany</aff>
<aff id="Aff141"><label>141</label>
Present address: Institut für Zellbiologie des Nervensystems, München, TU Germany</aff>
<aff id="Aff142"><label>142</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 973X</institution-id>
<institution-id institution-id-type="GRID">grid.5252.0</institution-id>
<institution>Present address: Institut für Immunologie, BioMedical Center, LMU,</institution>
</institution-wrap>
Planegg-Martinsried, Germany</aff>
<aff id="Aff143"><label>143</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Present address: Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</aff>
<aff id="Aff144"><label>144</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000000121581279</institution-id>
<institution-id institution-id-type="GRID">grid.10877.39</institution-id>
<institution>Laboratory for Optics and Biosciences,</institution>
<institution>Ecole Polytechnique,</institution>
</institution-wrap>
Palaiseau, France</aff>
<aff id="Aff145"><label>145</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Biochemistry, Molecular Biology, and Biophysics,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, MN USA</aff>
<aff id="Aff146"><label>146</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000000419370394</institution-id>
<institution-id institution-id-type="GRID">grid.208078.5</institution-id>
<institution>Department of Cell Biology,</institution>
<institution>University of Connecticut Health Center,</institution>
</institution-wrap>
Farmington, CT USA</aff>
<aff id="Aff147"><label>147</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Surgery,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, MN USA</aff>
<aff id="Aff148"><label>148</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, MN USA</aff>
<aff id="Aff149"><label>149</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Biochemistry, Molecular Biology, and Biophysics,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, MN USA</aff>
<aff id="Aff150"><label>150</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Developmental and Surgical Sciences,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, MN USA</aff>
<aff id="Aff151"><label>151</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000000419370394</institution-id>
<institution-id institution-id-type="GRID">grid.208078.5</institution-id>
<institution>Department of Cell Biology,</institution>
<institution>University of Connecticut Health Center,</institution>
</institution-wrap>
Farmington, CT USA</aff>
<aff id="Aff152"><label>152</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7400</institution-id>
<institution-id institution-id-type="GRID">grid.256304.6</institution-id>
<institution>Department of Physical Therapy,</institution>
<institution>Georgia State University,</institution>
</institution-wrap>
Atlanta, GA USA</aff>
<aff id="Aff153"><label>153</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, MN USA</aff>
<aff id="Aff154"><label>154</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Cardiovascular Research II, Therapeutic Research Group, Drug Discovery, Bayer AG,</institution>
</institution-wrap>
Wuppertal, Germany</aff>
<aff id="Aff155"><label>155</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 4373</institution-id>
<institution-id institution-id-type="GRID">grid.7700.0</institution-id>
<institution>Department of Cardiac Surgery,</institution>
<institution>University of Heidelberg,</institution>
</institution-wrap>
Heidelberg, Germany</aff>
<aff id="Aff156"><label>156</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0942 9821</institution-id>
<institution-id institution-id-type="GRID">grid.11804.3c</institution-id>
<institution>Heart and Vascular Center,</institution>
<institution>Semmelweis University,</institution>
</institution-wrap>
Budapest, Hungary</aff>
<aff id="Aff157"><label>157</label>
Humboldt Universität zu Berlin, Institute for Biology, Experimental Biophysics, Berlin, Germany</aff>
<aff id="Aff158"><label>158</label>
University Medical Center Hamburg-Eppendorf, Center for Molecular Neurobiology Hamburg, Institute for Synaptic Physiology, Hamburg, Germany</aff>
<aff id="Aff159"><label>159</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0550 9586</institution-id>
<institution-id institution-id-type="GRID">grid.438114.b</institution-id>
<institution>Center of Advanced European Studies and Research (caesar) Bonn, Department: Molecular Sensory Systems,</institution>
</institution-wrap>
Bonn, Germany</aff>
<aff id="Aff160"><label>160</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfaculty Institute of Biochemistry,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</aff>
<aff id="Aff161"><label>161</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1014 0849</institution-id>
<institution-id institution-id-type="GRID">grid.419491.0</institution-id>
<institution>Max Delbrück Center for Molecular Medicine in the Helmholtz Association,</institution>
</institution-wrap>
Berlin, Germany</aff>
<aff id="Aff162"><label>162</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id>
<institution-id institution-id-type="GRID">grid.17635.36</institution-id>
<institution>Department of Biochemistry,</institution>
<institution>University of Minnesota,</institution>
</institution-wrap>
Minneapolis, Minnesota USA</aff>
<aff id="Aff163"><label>163</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000000419370394</institution-id>
<institution-id institution-id-type="GRID">grid.208078.5</institution-id>
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<institution>University of Connecticut Health Center,</institution>
</institution-wrap>
Farmington, Connecticut USA</aff>
<aff id="Aff164"><label>164</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 3484</institution-id>
<institution-id institution-id-type="GRID">grid.13648.38</institution-id>
<institution>Institute of Experimental Cardiovascular Research,</institution>
<institution>University Medical Center Hamburg-Eppendorf,</institution>
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20246 Hamburg, Germany</aff>
<aff id="Aff165"><label>165</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2113 8111</institution-id>
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<institution>Department of Myocardial Function, Imperial College London, Hammersmith Hospital,</institution>
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W12 0NN, London, England UK</aff>
<aff id="Aff166"><label>166</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
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<institution>Universität Würzburg,</institution>
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97070 Würzburg, Germany</aff>
<aff id="Aff167"><label>167</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000000121539003</institution-id>
<institution-id institution-id-type="GRID">grid.5110.5</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>University of Graz,</institution>
</institution-wrap>
A 8010 Graz, Austria</aff>
<aff id="Aff168"><label>168</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0490 981X</institution-id>
<institution-id institution-id-type="GRID">grid.5570.7</institution-id>
<institution>Department of Pharmacology and Toxicology,</institution>
<institution>Ruhr University Bochum,</institution>
</institution-wrap>
D 44780 Bochum, Germany</aff>
<aff id="Aff169"><label>169</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2181 7878</institution-id>
<institution-id institution-id-type="GRID">grid.47840.3f</institution-id>
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<institution>University of California San Diego,</institution>
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La Jolla, California, 92093 USA</aff>
<aff id="Aff170"><label>170</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9206 2401</institution-id>
<institution-id institution-id-type="GRID">grid.267308.8</institution-id>
<institution>Division of Medical Genetics and Cardiology, Department of Internal Medicine,</institution>
<institution>The University of Texas Health Science Center at Houston,</institution>
</institution-wrap>
Houston, Texas 77030 USA</aff>
<aff id="Aff171"><label>171</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</aff>
<aff id="Aff172"><label>172</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0576 5395</institution-id>
<institution-id institution-id-type="GRID">grid.11047.33</institution-id>
<institution>Department of Pharmacy,</institution>
<institution>University of Patras,</institution>
</institution-wrap>
GR-26504 Patras, Greece</aff>
<aff id="Aff173"><label>173</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2230 9752</institution-id>
<institution-id institution-id-type="GRID">grid.9647.c</institution-id>
<institution>Institute of Organic Chemistry,</institution>
<institution>Leipzig University,</institution>
</institution-wrap>
D-04103 Leipzig, Germany</aff>
<aff id="Aff174"><label>174</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2155 0800</institution-id>
<institution-id institution-id-type="GRID">grid.5216.0</institution-id>
<institution>School of Health Sciences, Faculty of Pharmacy,</institution>
<institution>University of Athens,</institution>
</institution-wrap>
GR-15 771 Athens, Greece</aff>
<aff id="Aff175"><label>175</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0675 4725</institution-id>
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Cleveland, Ohio 44195 USA</aff>
<aff id="Aff176"><label>176</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0737 1259</institution-id>
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<institution>Kansas State University,</institution>
</institution-wrap>
Manhattan, Kansas 66506 USA</aff>
<aff id="Aff177"><label>177</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
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Cambridge, MA 02142 USA</aff>
<aff id="Aff178"><label>178</label>
Decibel Therapeutics, Cambridge, MA 02142 USA</aff>
<aff id="Aff179"><label>179</label>
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<institution-id institution-id-type="GRID">grid.5012.6</institution-id>
<institution>Department for Pharmacology and Personalized Medicine, CARIM, FHML,</institution>
<institution>Maastricht University,</institution>
</institution-wrap>
Maastricht, The Netherlands</aff>
<aff id="Aff180"><label>180</label>
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<institution>Department of Pharmacology,</institution>
<institution>Johannes Gutenberg University,</institution>
</institution-wrap>
Mainz, Germany</aff>
<aff id="Aff181"><label>181</label>
Asklepios-Klinik Radeberg, Dresden, Germany</aff>
<aff id="Aff182"><label>182</label>
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<institution>Katholieke Universiteit Leuven,</institution>
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Leuven, Belgium</aff>
<aff id="Aff183"><label>183</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2111 7257</institution-id>
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<institution>Technische Universität,</institution>
</institution-wrap>
Dresden, Germany</aff>
<aff id="Aff184"><label>184</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2207 2097</institution-id>
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<institution>Facultad de Química, Universidad Autónoma de Querétaro,</institution>
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Santiago de Querétaro, Mexico</aff>
<aff id="Aff185"><label>185</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2176 9917</institution-id>
<institution-id institution-id-type="GRID">grid.411327.2</institution-id>
<institution>Institut für Herz- und Kreislaufphysiologie Heinrich-Heine-Universität,</institution>
</institution-wrap>
Düsseldorf, Germany</aff>
<aff id="Aff186"><label>186</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Interfakultäres Institut für Biochemie,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</aff>
<aff id="Aff187"><label>187</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</aff>
<aff id="Aff188"><label>188</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id>
<institution-id institution-id-type="GRID">grid.10392.39</institution-id>
<institution>Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy,</institution>
<institution>University of Tübingen,</institution>
</institution-wrap>
Tübingen, Germany</aff>
<aff id="Aff189"><label>189</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7988</institution-id>
<institution-id institution-id-type="GRID">grid.4305.2</institution-id>
<institution>Centre for Integrative Physiology, School of Biomedical Science, Hugh Robson Building,</institution>
<institution>University of Edinburgh,</institution>
</institution-wrap>
Edinburgh, Scotland EH8 9XD UK</aff>
<aff id="Aff190"><label>190</label>
<institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School,</institution>
</institution-wrap>
Boston, Massachusetts USA</aff>
<aff id="Aff191"><label>191</label>
<institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital and Harvard Medical School,</institution>
</institution-wrap>
Boston, Massachusetts USA</aff>
<aff id="Aff192"><label>192</label>
<institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Harvard Stem Cell Institute,</institution>
</institution-wrap>
Cambridge, Massachusetts USA</aff>
<aff id="Aff193"><label>193</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.66859.34</institution-id>
<institution>Program in Medical and Population Genetics, Broad Institute,</institution>
</institution-wrap>
Cambridge, Massachusetts USA</aff>
<aff id="Aff194"><label>194</label>
<institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School,</institution>
</institution-wrap>
Boston, Massachusetts USA</aff>
<aff id="Aff195"><label>195</label>
<institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School,</institution>
</institution-wrap>
Boston, Massachusetts USA</aff>
<aff id="Aff196"><label>196</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id>
<institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution>Physiologisches Institut,</institution>
<institution>Universität Würzburg,</institution>
</institution-wrap>
Würzburg, Germany</aff>
<aff id="Aff197"><label>197</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0723 2494</institution-id>
<institution-id institution-id-type="GRID">grid.411087.b</institution-id>
<institution>Hematology Centre, School of Medical Sciences,</institution>
<institution>University of Campinas (UNICAMP),</institution>
</institution-wrap>
Sao Paolo, Brazil</aff>
<aff id="Aff198"><label>198</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 4101</institution-id>
<institution-id institution-id-type="GRID">grid.420044.6</institution-id>
<institution>Bayer AG, Pharmaceuticals - Drug Discovery,</institution>
</institution-wrap>
Wuppertal, Germany</aff>
<aff id="Aff199"><label>199</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2152 0791</institution-id>
<institution-id institution-id-type="GRID">grid.240283.f</institution-id>
<institution>Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine,</institution>
</institution-wrap>
Bronx, NY USA</aff>
<aff id="Aff200"><label>200</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0564 3590</institution-id>
<institution-id institution-id-type="GRID">grid.476501.1</institution-id>
<institution>Ironwood Pharmaceuticals,</institution>
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Cambridge, MA 02142 USA</aff>
</contrib-group>
<pub-date pub-type="epub"><day>10</day>
<month>10</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>10</day>
<month>10</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="collection"><year>2017</year>
</pub-date>
<volume>18</volume>
<issue>Suppl 1</issue>
<issue-sponsor>Publication of this supplement has been funded by FEBGLA e.V.</issue-sponsor>
<elocation-id>64</elocation-id>
<permissions><copyright-statement>© The Author(s). 2017</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<conference xlink:href="http://www.cyclicgmp.net/"><conf-name>8th International Conference on cGMP Generators, Effectors and Therapeutic Implications</conf-name>
<conf-acronym>8th cGMP</conf-acronym>
<conf-loc>Bamberg, Germany</conf-loc>
<conf-date>23-25 June, 2017</conf-date>
</conference>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2017</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>
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