Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer
Identifieur interne : 000767 ( Pmc/Curation ); précédent : 000766; suivant : 000768Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer
Auteurs : Fergus J. Couch [États-Unis] ; Karoline B. Kuchenbaecker [Royaume-Uni] ; Kyriaki Michailidou [Royaume-Uni] ; Gustavo A. Mendoza-Fandino [États-Unis] ; Silje Nord [Norvège] ; Janna Lilyquist [États-Unis] ; Curtis Olswold [États-Unis] ; Emily Hallberg [États-Unis] ; Simona Agata [Italie] ; Habibul Ahsan [États-Unis] ; Kristiina Aittom Ki [Finlande] ; Christine Ambrosone [États-Unis] ; Irene L. Andrulis [Canada] ; Hoda Anton-Culver [États-Unis] ; Volker Arndt [Allemagne] ; Banu K. Arun [États-Unis] ; Brita Arver [Suède] ; Monica Barile [Italie] ; Rosa B. Barkardottir [Islande] ; Daniel Barrowdale [Royaume-Uni] ; Lars Beckmann [Allemagne] ; Matthias W. Beckmann [Allemagne] ; Javier Benitez [Espagne] ; Stephanie V. Blank [États-Unis] ; Carl Blomqvist [Finlande] ; Natalia V. Bogdanova [Allemagne] ; Stig E. Bojesen [Danemark] ; Manjeet K. Bolla [Royaume-Uni] ; Bernardo Bonanni [Italie] ; Hiltrud Brauch [Allemagne] ; Hermann Brenner [Allemagne] ; Barbara Burwinkel [Allemagne] ; Saundra S. Buys [États-Unis] ; Trinidad Caldes [Espagne] ; Maria A. Caligo [Italie] ; Federico Canzian [Allemagne] ; Jane Carpenter [Australie] ; Jenny Chang-Claude [Allemagne] ; Stephen J. Chanock [États-Unis] ; Wendy K. Chung [États-Unis] ; Kathleen B. M. Claes [Belgique] ; Angela Cox [Royaume-Uni] ; Simon S. Cross [Royaume-Uni] ; Julie M. Cunningham [États-Unis] ; Kamila Czene [Suède] ; Mary B. Daly [États-Unis] ; Francesca Damiola [France] ; Hatef Darabi [Suède] ; Miguel De La Hoya [Espagne] ; Peter Devilee [Pays-Bas] ; Orland Diez [Espagne] ; Yuan C. Ding [États-Unis] ; Riccardo Dolcetti [Italie] ; Susan M. Domchek [États-Unis] ; Cecilia M. Dorfling [Afrique du Sud] ; Isabel Dos-Santos-Silva [Royaume-Uni] ; Martine Dumont [Canada] ; Alison M. Dunning [Royaume-Uni] ; Diana M. Eccles [Royaume-Uni] ; Hans Ehrencrona [Suède] ; Arif B. Ekici [Allemagne] ; Heather Eliassen [États-Unis] ; Steve Ellis [Royaume-Uni] ; Peter A. Fasching [Allemagne] ; Jonine Figueroa [États-Unis] ; Dieter Flesch-Janys [Allemagne] ; Asta Försti [Allemagne, Suède] ; Florentia Fostira [Grèce] ; William D. Foulkes [Canada] ; Tara Friebel [États-Unis] ; Eitan Friedman [Israël] ; Debra Frost [Royaume-Uni] ; Marike Gabrielson [Suède] ; Marilie D. Gammon [États-Unis] ; Patricia A. Ganz [États-Unis] ; Susan M. Gapstur [États-Unis] ; Judy Garber [États-Unis] ; Mia M. Gaudet [États-Unis] ; Simon A. Gayther [États-Unis] ; Anne-Marie Gerdes [Danemark] ; Maya Ghoussaini [Royaume-Uni] ; Graham G. Giles [Australie] ; Gord Glendon [Canada] ; Andrew K. Godwin [États-Unis] ; Mark S. Goldberg [Canada] ; David E. Goldgar [États-Unis] ; Anna González-Neira [Espagne] ; Mark H. Greene [États-Unis] ; Jacek Gronwald [Pologne] ; Pascal Guénel [France] ; Marc Gunter [Royaume-Uni] ; Lothar Haeberle [Allemagne] ; Christopher A. Haiman [États-Unis] ; Ute Hamann [Allemagne] ; Thomas V. O. Hansen [Danemark] ; Steven Hart [États-Unis] ; Sue Healey [Australie] ; Tuomas Heikkinen [Allemagne, Finlande] ; Brian E. Henderson [États-Unis] ; Josef Herzog [États-Unis] ; Frans B. L. Hogervorst [Pays-Bas] ; Antoinette Hollestelle [Pays-Bas] ; Maartje J. Hooning [Pays-Bas] ; Robert N. Hoover [États-Unis] ; John L. Hopper [Australie] ; Keith Humphreys [Suède] ; David J. Hunter [États-Unis] ; Tomasz Huzarski [Pologne] ; Evgeny N. Imyanitov [Russie] ; Claudine Isaacs [États-Unis] ; Anna Jakubowska [Pologne] ; Paul James [Australie] ; Ramunas Janavicius [Lituanie] ; Uffe Birk Jensen [Danemark] ; Esther M. John [États-Unis] ; Michael Jones [Royaume-Uni] ; Maria Kabisch [Allemagne] ; Siddhartha Kar [Royaume-Uni] ; Beth Y. Karlan [États-Unis] ; Sofia Khan [Finlande] ; Kay-Tee Khaw [Royaume-Uni] ; Muhammad G. Kibriya [États-Unis] ; Julia A. Knight [Canada] ; Yon-Dschun Ko [Allemagne] ; Irene Konstantopoulou [Grèce] ; Veli-Matti Kosma [Finlande] ; Vessela Kristensen [Norvège] ; Ava Kwong [Hong Kong, République populaire de Chine] ; Yael Laitman [Israël] ; Diether Lambrechts [Belgique] ; Conxi Lazaro [Espagne] ; Eunjung Lee [États-Unis] ; Loic Le Marchand [États-Unis] ; Jenny Lester [États-Unis] ; Annika Lindblom [Suède] ; Noralane Lindor [États-Unis] ; Sara Lindstrom [États-Unis] ; Jianjun Liu [Singapour] ; Jirong Long [États-Unis] ; Jan Lubinski [Pologne] ; Phuong L. Mai [États-Unis] ; Enes Makalic [Australie] ; Kathleen E. Malone [États-Unis] ; Arto Mannermaa [Finlande] ; Siranoush Manoukian [Italie] ; Sara Margolin [Suède] ; Frederik Marme [Allemagne] ; John W. M. Martens [Pays-Bas] ; Lesley Mcguffog [Royaume-Uni] ; Alfons Meindl [Allemagne] ; Austin Miller [États-Unis] ; Roger L. Milne [Australie] ; Penelope Miron [États-Unis] ; Marco Montagna [Italie] ; Sylvie Mazoyer [France] ; Anna M. Mulligan [Canada] ; Taru A. Muranen [Allemagne, Finlande] ; Katherine L. Nathanson [États-Unis] ; Susan L. Neuhausen [États-Unis] ; Heli Nevanlinna [Finlande] ; B Rge G. Nordestgaard [Danemark] ; Robert L. Nussbaum [États-Unis] ; Kenneth Offit [États-Unis] ; Edith Olah [Hongrie] ; Olufunmilayo I. Olopade [États-Unis] ; Janet E. Olson [États-Unis] ; Ana Osorio [Espagne] ; Sue K. Park [Corée du Sud] ; Petra H. Peeters [Pays-Bas, Royaume-Uni] ; Bernard Peissel [Italie] ; Paolo Peterlongo [Italie] ; Julian Peto [Royaume-Uni] ; Catherine M. Phelan [États-Unis] ; Robert Pilarski [États-Unis] ; Bruce Poppe [Belgique] ; Katri Pylk S [Finlande] ; Paolo Radice [Italie] ; Nazneen Rahman [Royaume-Uni] ; Johanna Rantala [Suède] ; Christine Rappaport [Autriche] ; Gad Rennert [Israël] ; Andrea Richardson [États-Unis] ; Mark Robson [États-Unis] ; Isabelle Romieu [France] ; Anja Rudolph [Allemagne] ; Emiel J. Rutgers [Pays-Bas] ; Maria-Jose Sanchez [Espagne] ; Regina M. Santella [États-Unis] ; Elinor J. Sawyer [Royaume-Uni] ; Daniel F. Schmidt [Australie] ; Marjanka K. Schmidt [Pays-Bas] ; Rita K. Schmutzler [Allemagne] ; Fredrick Schumacher [États-Unis] ; Rodney Scott [Australie] ; Leigha Senter [États-Unis] ; Priyanka Sharma [États-Unis] ; Jacques Simard [Canada] ; Christian F. Singer [Autriche] ; Olga M. Sinilnikova [France] ; Penny Soucy [Canada] ; Melissa Southey [Australie] ; Doris Steinemann [Allemagne] ; Marie Stenmark-Askmalm [Suède] ; Dominique Stoppa-Lyonnet [France] ; Anthony Swerdlow [Royaume-Uni] ; Csilla I. Szabo [États-Unis] ; Rulla Tamimi [États-Unis] ; William Tapper [Royaume-Uni] ; Manuel R. Teixeira [Portugal] ; Soo-Hwang Teo [Malaisie] ; Mary B. Terry [États-Unis] ; Mads Thomassen [Danemark] ; Deborah Thompson [Royaume-Uni] ; Laima Tihomirova [Lettonie] ; Amanda E. Toland [États-Unis] ; Robert A. E. M. Tollenaar [Pays-Bas] ; Ian Tomlinson [Royaume-Uni] ; Thérèse Truong [France] ; Helen Tsimiklis [Australie] ; Alex Teulé [Espagne] ; Rosario Tumino [Italie] ; Nadine Tung [États-Unis] ; Clare Turnbull [Royaume-Uni] ; Giski Ursin [Norvège] ; Carolien H. M. Van Deurzen [Pays-Bas] ; Elizabeth J. Van Rensburg [Afrique du Sud] ; Raymonda Varon-Mateeva [Allemagne] ; Zhaoming Wang [États-Unis] ; Shan Wang-Gohrke [Allemagne] ; Elisabete Weiderpass [Suède, Norvège, Finlande] ; Jeffrey N. Weitzel [États-Unis] ; Alice Whittemore [États-Unis] ; Hans Wildiers [Belgique] ; Robert Winqvist [Finlande] ; Xiaohong R. Yang [États-Unis] ; Drakoulis Yannoukakos [Grèce] ; Song Yao [États-Unis] ; M Pilar Zamora [Espagne] ; Wei Zheng [États-Unis] ; Per Hall [Suède] ; Peter Kraft [États-Unis] ; Celine Vachon [États-Unis] ; Susan Slager [États-Unis] ; Georgia Chenevix-Trench [Australie] ; Paul D. P. Pharoah [Royaume-Uni] ; Alvaro A. N. Monteiro [États-Unis] ; Montserrat García-Closas [États-Unis] ; Douglas F. Easton [Royaume-Uni] ; Antonis C. Antoniou [Royaume-Uni]Source :
- Nature Communications [ 2041-1723 ] ; 2016.
Abstract
Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (
Url:
DOI: 10.1038/ncomms11375
PubMed: 27117709
PubMed Central: 4853421
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PMC:4853421Le document en format XML
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Andrulis</name><affiliation wicri:level="1"><nlm:aff id="a12"><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>, Toronto, Ontario,<country>Canada</country> M5G 1X5</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a13"><institution>Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto</institution>, Ontario,<country>Canada</country> M5B 1W8</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation wicri:level="1"><nlm:aff id="a14"><institution>Department of Epidemiology, University of California Irvine</institution>, Irvine, California, 92697,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation wicri:level="1"><nlm:aff id="a15"><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Arun, Banu K" sort="Arun, Banu K" uniqKey="Arun B" first="Banu K." last="Arun">Banu K. Arun</name><affiliation wicri:level="1"><nlm:aff id="a16"><institution>University of Texas MD Anderson Cancer Center</institution>, Houston, Texas 77030,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Arver, Brita" sort="Arver, Brita" uniqKey="Arver B" first="Brita" last="Arver">Brita Arver</name><affiliation wicri:level="1"><nlm:aff id="a17"><institution>Department of Oncology, Karolinska University Hospital</institution>, SE-17176 Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barile, Monica" sort="Barile, Monica" uniqKey="Barile M" first="Monica" last="Barile">Monica Barile</name><affiliation wicri:level="1"><nlm:aff id="a18"><institution>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia</institution>, 20141 Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barkardottir, Rosa B" sort="Barkardottir, Rosa B" uniqKey="Barkardottir R" first="Rosa B." last="Barkardottir">Rosa B. Barkardottir</name><affiliation wicri:level="1"><nlm:aff id="a19"><institution>Department of Pathology, Landspitali University Hospital and University of Iceland School of Medicine</institution>, 101 Reykjavik,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barrowdale, Daniel" sort="Barrowdale, Daniel" uniqKey="Barrowdale D" first="Daniel" last="Barrowdale">Daniel Barrowdale</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Beckmann, Lars" sort="Beckmann, Lars" uniqKey="Beckmann L" first="Lars" last="Beckmann">Lars Beckmann</name><affiliation wicri:level="1"><nlm:aff id="a20"><institution>Institute for Quality and Efficiency in Health Care (IQWiG)</institution>, 50670 Cologne,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation wicri:level="1"><nlm:aff id="a21"><institution>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN</institution>, 91054 Erlangen,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation wicri:level="1"><nlm:aff id="a22"><institution>Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO)</institution>, 28029 Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a23"><institution>Genotyping Unit (CeGen), Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO)</institution>, 28029 Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a24"><institution>Biomedical Network on Rare Diseases (CIBERER)</institution>, 28029 Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blank, Stephanie V" sort="Blank, Stephanie V" uniqKey="Blank S" first="Stephanie V." last="Blank">Stephanie V. Blank</name><affiliation wicri:level="1"><nlm:aff id="a25"><institution>NYU Women's Cancer Program, New York University School of Medicine</institution>, New York, New York 10016,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation wicri:level="1"><nlm:aff id="a26"><institution>Department of Oncology, University of Helsinki and Helsinki University Central Hospital</institution>, FI-00029 Helsinki,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation wicri:level="1"><nlm:aff id="a27"><institution>Department of Radiation Oncology, Hannover Medical School</institution>, 30625 Hannover,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation wicri:level="1"><nlm:aff id="a28"><institution>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital</institution>, 2730 Herlev,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name><affiliation wicri:level="1"><nlm:aff id="a18"><institution>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia</institution>, 20141 Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation wicri:level="1"><nlm:aff id="a29"><institution>Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology</institution>, 70376 Stuttgart,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a30"><institution>University of Tübingen</institution> 72074 Tübingen,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="1"><nlm:aff id="a15"><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a31"><institution>Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT)</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation wicri:level="1"><nlm:aff id="a32"><institution>Department of Obstetrics and Gynecology, University of Heidelberg</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S." last="Buys">Saundra S. Buys</name><affiliation wicri:level="1"><nlm:aff id="a33"><institution>Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine</institution>, Salt Lake City Utah 84112,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name><affiliation wicri:level="1"><nlm:aff id="a34"><institution>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC</institution>, Madrid 28040,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A." last="Caligo">Maria A. Caligo</name><affiliation wicri:level="1"><nlm:aff id="a35"><institution>Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa</institution>, I-56126 Pisa,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name><affiliation wicri:level="1"><nlm:aff id="a36"><institution>Genomic Epidemiology Group, German Cancer Research Center (DKFZ)</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Carpenter, Jane" sort="Carpenter, Jane" uniqKey="Carpenter J" first="Jane" last="Carpenter">Jane Carpenter</name><affiliation wicri:level="1"><nlm:aff id="a37"><institution>Australian Breast Cancer Tissue Bank, Westmead Millennium Institute, University of Sydney</institution>, Sydney, New South Wales 2145,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation wicri:level="1"><nlm:aff id="a38"><institution>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="1"><nlm:aff id="a39"><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>, Rockville, Maryland 20850,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chung, Wendy K" sort="Chung, Wendy K" uniqKey="Chung W" first="Wendy K." last="Chung">Wendy K. Chung</name><affiliation wicri:level="1"><nlm:aff id="a40"><institution>Departments of Pediatrics and Medicine, Columbia University</institution>, New York, New York 10032,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Claes, Kathleen B M" sort="Claes, Kathleen B M" uniqKey="Claes K" first="Kathleen B. M." last="Claes">Kathleen B. M. Claes</name><affiliation wicri:level="1"><nlm:aff id="a41"><institution>Center for Medical Genetics, Ghent University</institution>, 9000 Ghent,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation wicri:level="1"><nlm:aff id="a42"><institution>Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield</institution>, Sheffield S10 2RX,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation wicri:level="1"><nlm:aff id="a43"><institution>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield</institution>, Sheffield S10 2HQ,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cunningham, Julie M" sort="Cunningham, Julie M" uniqKey="Cunningham J" first="Julie M." last="Cunningham">Julie M. Cunningham</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution>, Rochester, Minnesota 55905,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation wicri:level="1"><nlm:aff id="a44"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, SE-17177 Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B." last="Daly">Mary B. Daly</name><affiliation wicri:level="1"><nlm:aff id="a45"><institution>Department of Clinical Genetics, Fox Chase Cancer Center</institution>, Philadelphia, Pennsylvania 19111,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Damiola, Francesca" sort="Damiola, Francesca" uniqKey="Damiola F" first="Francesca" last="Damiola">Francesca Damiola</name><affiliation wicri:level="1"><nlm:aff id="a46"><institution>INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon</institution>, 69373 Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation wicri:level="1"><nlm:aff id="a44"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, SE-17177 Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De La Hoya, Miguel" sort="De La Hoya, Miguel" uniqKey="De La Hoya M" first="Miguel" last="De La Hoya">Miguel De La Hoya</name><affiliation wicri:level="1"><nlm:aff id="a34"><institution>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC</institution>, Madrid 28040,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation wicri:level="1"><nlm:aff id="a47"><institution>Department of Human Genetics and Department of Pathology, Leiden University Medical Center</institution>, Leiden 2333 ZC,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Diez, Orland" sort="Diez, Orland" uniqKey="Diez O" first="Orland" last="Diez">Orland Diez</name><affiliation wicri:level="1"><nlm:aff id="a48"><institution>Oncogenetics Group, University Hospital Vall d'Hebron, Vall d'Hebron Institute of Oncology (VHIO) and Universitat Autònoma de Barcelona</institution>, 08035 Barcelona,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ding, Yuan C" sort="Ding, Yuan C" uniqKey="Ding Y" first="Yuan C." last="Ding">Yuan C. Ding</name><affiliation wicri:level="1"><nlm:aff id="a49"><institution>Department of Population Sciences, Beckman Research Institute of City of Hope</institution>, Duarte, California 91010,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dolcetti, Riccardo" sort="Dolcetti, Riccardo" uniqKey="Dolcetti R" first="Riccardo" last="Dolcetti">Riccardo Dolcetti</name><affiliation wicri:level="1"><nlm:aff id="a50"><institution>Cancer Bioimmunotherapy Unit, CRO Aviano National Cancer Institute</institution>, 33081 Aviano ,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M." last="Domchek">Susan M. Domchek</name><affiliation wicri:level="1"><nlm:aff id="a51"><institution>Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania</institution>, Pennsylvania 19104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dorfling, Cecilia M" sort="Dorfling, Cecilia M" uniqKey="Dorfling C" first="Cecilia M." last="Dorfling">Cecilia M. Dorfling</name><affiliation wicri:level="1"><nlm:aff id="a52"><institution>Department of Genetics, University of Pretoria</institution>, Pretoria 0007,<country>South Africa</country></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation wicri:level="1"><nlm:aff id="a53"><institution>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine</institution>, London, WC1E 7HT,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name><affiliation wicri:level="1"><nlm:aff id="a54"><institution>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University</institution>, Quebec City, Quebec,<country>Canada</country> G1V 4G2</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation wicri:level="1"><nlm:aff id="a55"><institution>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eccles, Diana M" sort="Eccles, Diana M" uniqKey="Eccles D" first="Diana M." last="Eccles">Diana M. Eccles</name><affiliation wicri:level="1"><nlm:aff id="a56"><institution>Faculty of Medicine, University of Southampton, University Hospital Southampton</institution>, Southampton, Hampshire SO16 6YD,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ehrencrona, Hans" sort="Ehrencrona, Hans" uniqKey="Ehrencrona H" first="Hans" last="Ehrencrona">Hans Ehrencrona</name><affiliation wicri:level="1"><nlm:aff id="a57"><institution>Department of Immunology, Genetics and Pathology, Uppsala University</institution>, Uppsala SE-751 85,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a58"><institution>Department of Clinical Genetics, Lund University Hospital</institution>, SE-22185 Lund,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation wicri:level="1"><nlm:aff id="a59"><institution>Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg</institution>, 91054 Erlangen,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a60"><institution>Comprehensive Cancer Center -EMN</institution>, 91054 Erlangen,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eliassen, Heather" sort="Eliassen, Heather" uniqKey="Eliassen H" first="Heather" last="Eliassen">Heather Eliassen</name><affiliation wicri:level="1"><nlm:aff id="a61"><institution>Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a62"><institution>Department of Epidemiology, Harvard School of Public Health</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ellis, Steve" sort="Ellis, Steve" uniqKey="Ellis S" first="Steve" last="Ellis">Steve Ellis</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation wicri:level="1"><nlm:aff id="a21"><institution>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN</institution>, 91054 Erlangen,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation wicri:level="1"><nlm:aff id="a39"><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>, Rockville, Maryland 20850,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation wicri:level="1"><nlm:aff id="a63"><institution>Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf</institution>, 20246 Hamburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Forsti, Asta" sort="Forsti, Asta" uniqKey="Forsti A" first="Asta" last="Försti">Asta Försti</name><affiliation wicri:level="1"><nlm:aff id="a64"><institution>Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ)</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a65"><institution>Center for Primary Health Care Research, Lund University</institution>, SE-221 00 Malmö,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fostira, Florentia" sort="Fostira, Florentia" uniqKey="Fostira F" first="Florentia" last="Fostira">Florentia Fostira</name><affiliation wicri:level="1"><nlm:aff id="a66"><institution>Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research ‘Demokritos', Aghia Paraskevi Attikis</institution>, 15310 Athens,<country>Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Foulkes, William D" sort="Foulkes, William D" uniqKey="Foulkes W" first="William D." last="Foulkes">William D. Foulkes</name><affiliation wicri:level="1"><nlm:aff id="a67"><institution>Program in Cancer Genetics, McGill University</institution>, Montreal, Quebec,<country>Canada</country> H3A 0G4</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Friebel, Tara" sort="Friebel, Tara" uniqKey="Friebel T" first="Tara" last="Friebel">Tara Friebel</name><affiliation wicri:level="1"><nlm:aff id="a68"><institution>University of</institution>, Philadelphia, Pennsylvania 19104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><affiliation wicri:level="1"><nlm:aff id="a69"><institution>Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center</institution>, Tel-Hashomer 52621,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gabrielson, Marike" sort="Gabrielson, Marike" uniqKey="Gabrielson M" first="Marike" last="Gabrielson">Marike Gabrielson</name><affiliation wicri:level="1"><nlm:aff id="a44"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, SE-17177 Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gammon, Marilie D" sort="Gammon, Marilie D" uniqKey="Gammon M" first="Marilie D." last="Gammon">Marilie D. Gammon</name><affiliation wicri:level="1"><nlm:aff id="a70"><institution>Department of Epidemiology, University of</institution>, Chapel Hill, North Carolina 27599-7400,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name><affiliation wicri:level="1"><nlm:aff id="a71"><institution>UCLA Schools of Medicine and Public Health, Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center</institution>, Los Angeles, California 90095-6900,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gapstur, Susan M" sort="Gapstur, Susan M" uniqKey="Gapstur S" first="Susan M." last="Gapstur">Susan M. Gapstur</name><affiliation wicri:level="1"><nlm:aff id="a72"><institution>Epidemiology Research Program, American Cancer Society</institution>, Atlanta, Georgia 30303,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Garber, Judy" sort="Garber, Judy" uniqKey="Garber J" first="Judy" last="Garber">Judy Garber</name><affiliation wicri:level="1"><nlm:aff id="a73"><institution>Cancer Risk and Prevention Clinic, Dana Farber Cancer Institute</institution>, Boston, Massachusetts 02215,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M." last="Gaudet">Mia M. Gaudet</name><affiliation wicri:level="1"><nlm:aff id="a72"><institution>Epidemiology Research Program, American Cancer Society</institution>, Atlanta, Georgia 30303,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gayther, Simon A" sort="Gayther, Simon A" uniqKey="Gayther S" first="Simon A." last="Gayther">Simon A. Gayther</name><affiliation wicri:level="1"><nlm:aff id="a74"><institution>Department of Biomedical Sciences, Cedars Sinai Medical Center</institution>, Los Angeles, California 90048,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gerdes, Anne Marie" sort="Gerdes, Anne Marie" uniqKey="Gerdes A" first="Anne-Marie" last="Gerdes">Anne-Marie Gerdes</name><affiliation wicri:level="1"><nlm:aff id="a75"><institution>Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital</institution>, DK-2100 Copenhagen,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name><affiliation wicri:level="1"><nlm:aff id="a55"><institution>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation wicri:level="1"><nlm:aff id="a76"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>, Melbourne, Victoria 3010,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation wicri:level="1"><nlm:aff id="a12"><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>, Toronto, Ontario,<country>Canada</country> M5G 1X5</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name><affiliation wicri:level="1"><nlm:aff id="a77"><institution>Department of Pathology and Laboratory Medicine, University of Kansas Medical Center</institution>, Kansas City, Kansas, 66205,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S." last="Goldberg">Mark S. Goldberg</name><affiliation wicri:level="1"><nlm:aff id="a78"><institution>Department of Medicine, McGill University</institution>, Montreal, Quebec,<country>Canada</country> H3G 2M1</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a79"><institution>Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital</institution>, Montreal, Quebec,<country>Canada</country> H4A 3J1</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E." last="Goldgar">David E. Goldgar</name><affiliation wicri:level="1"><nlm:aff id="a80"><institution>Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine</institution>, Salt Lake City, Utah 84132,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation wicri:level="1"><nlm:aff id="a81"><institution>Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)</institution>, 28029 Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><affiliation wicri:level="1"><nlm:aff id="a82"><institution>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</institution>, Rockville, Maryland 20850-9772,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name><affiliation wicri:level="1"><nlm:aff id="a83"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation wicri:level="1"><nlm:aff id="a84"><institution>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer</institution>, 70-115 Villejuif,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gunter, Marc" sort="Gunter, Marc" uniqKey="Gunter M" first="Marc" last="Gunter">Marc Gunter</name><affiliation wicri:level="1"><nlm:aff id="a85"><institution>Department of of Epidemiology and Biostatistics, School of Public Health, Imperial College London</institution>, London, SW7 2AZ,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haeberle, Lothar" sort="Haeberle, Lothar" uniqKey="Haeberle L" first="Lothar" last="Haeberle">Lothar Haeberle</name><affiliation wicri:level="1"><nlm:aff id="a21"><institution>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN</institution>, 91054 Erlangen,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="1"><nlm:aff id="a86"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center</institution>, Los Angeles, California 90033,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation wicri:level="1"><nlm:aff id="a87"><institution>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V. O." last="Hansen">Thomas V. O. Hansen</name><affiliation wicri:level="1"><nlm:aff id="a88"><institution>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital</institution>, DK-2100 Copenhagen,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hart, Steven" sort="Hart, Steven" uniqKey="Hart S" first="Steven" last="Hart">Steven Hart</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, Minnesota 55905,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name><affiliation wicri:level="1"><nlm:aff id="a89"><institution>Department of Genetics, QIMR Berghofer Medical Research Institute</institution>, Brisbane, Queensland 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Heikkinen, Tuomas" sort="Heikkinen, Tuomas" uniqKey="Heikkinen T" first="Tuomas" last="Heikkinen">Tuomas Heikkinen</name><affiliation wicri:level="1"><nlm:aff id="a32"><institution>Department of Obstetrics and Gynecology, University of Heidelberg</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a90"><institution>Helsinki University Central Hospital</institution>, FI-00029 Helsinki,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation wicri:level="1"><nlm:aff id="a86"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center</institution>, Los Angeles, California 90033,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Herzog, Josef" sort="Herzog, Josef" uniqKey="Herzog J" first="Josef" last="Herzog">Josef Herzog</name><affiliation wicri:level="1"><nlm:aff id="a91"><institution>Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network</institution>, Duarte, California 91010,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B. L." last="Hogervorst">Frans B. L. Hogervorst</name><affiliation wicri:level="1"><nlm:aff id="a92"><institution>Family Cancer Clinic, Netherlands Cancer Institute</institution>, Amsterdam 1000 BE,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation wicri:level="1"><nlm:aff id="a93"><institution>Department of Medical Oncology, Erasmus MC Cancer Institute</institution>, Rotterdam 3008 AE,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name><affiliation wicri:level="1"><nlm:aff id="a94"><institution>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center</institution>, Rotterdam 3008 AE,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N." last="Hoover">Robert N. Hoover</name><affiliation wicri:level="1"><nlm:aff id="a39"><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>, Rockville, Maryland 20850,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="1"><nlm:aff id="a95"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne</institution>, Melbourne, Victoria 3010,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name><affiliation wicri:level="1"><nlm:aff id="a44"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, SE-17177 Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation wicri:level="1"><nlm:aff id="a96"><institution>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huzarski, Tomasz" sort="Huzarski, Tomasz" uniqKey="Huzarski T" first="Tomasz" last="Huzarski">Tomasz Huzarski</name><affiliation wicri:level="1"><nlm:aff id="a83"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Imyanitov, Evgeny N" sort="Imyanitov, Evgeny N" uniqKey="Imyanitov E" first="Evgeny N." last="Imyanitov">Evgeny N. Imyanitov</name><affiliation wicri:level="1"><nlm:aff id="a97"><institution>N.N. Petrov Institute of Oncology</institution>, 197758 St Petersburg,<country>Russia</country></nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name><affiliation wicri:level="1"><nlm:aff id="a98"><institution>Lombardi Comprehensive Cancer Center, Georgetown University</institution>, Washington, DC 20007,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation wicri:level="1"><nlm:aff id="a83"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="James, Paul" sort="James, Paul" uniqKey="James P" first="Paul" last="James">Paul James</name><affiliation wicri:level="1"><nlm:aff id="a99"><institution>Familial Cancer Centre, Peter MacCallum Cancer Centre</institution>, Melbourne, Victoria 8006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a100"><institution>Department of Oncology, The University of Melbourne</institution>, Melbourne, Victoria 8006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Janavicius, Ramunas" sort="Janavicius, Ramunas" uniqKey="Janavicius R" first="Ramunas" last="Janavicius">Ramunas Janavicius</name><affiliation wicri:level="1"><nlm:aff id="a101"><institution>State Research Institute Centre for Innovative Medicine</institution>, LT-08661 Vilnius,<country>Lithuania</country></nlm:aff><country xml:lang="fr">Lituanie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jensen, Uffe Birk" sort="Jensen, Uffe Birk" uniqKey="Jensen U" first="Uffe Birk" last="Jensen">Uffe Birk Jensen</name><affiliation wicri:level="1"><nlm:aff id="a102"><institution>Department of Clinical Genetics, Aarhus University Hospital</institution>, 8200 Aarhus N,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name><affiliation wicri:level="1"><nlm:aff id="a103"><institution>Department of Epidemiology, Cancer Prevention Institute of California</institution>, Fremont, California 94538,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jones, Michael" sort="Jones, Michael" uniqKey="Jones M" first="Michael" last="Jones">Michael Jones</name><affiliation wicri:level="1"><nlm:aff id="a104"><institution>Division of Genetics and Epidemiology, Institute of Cancer Research</institution>, Sutton SM2 5NG,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kabisch, Maria" sort="Kabisch, Maria" uniqKey="Kabisch M" first="Maria" last="Kabisch">Maria Kabisch</name><affiliation wicri:level="1"><nlm:aff id="a87"><institution>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kar, Siddhartha" sort="Kar, Siddhartha" uniqKey="Kar S" first="Siddhartha" last="Kar">Siddhartha Kar</name><affiliation wicri:level="1"><nlm:aff id="a55"><institution>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y." last="Karlan">Beth Y. Karlan</name><affiliation wicri:level="1"><nlm:aff id="a105"><institution>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center</institution>, Los Angeles, California, 90048,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Khan, Sofia" sort="Khan, Sofia" uniqKey="Khan S" first="Sofia" last="Khan">Sofia Khan</name><affiliation wicri:level="1"><nlm:aff id="a106"><institution>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital</institution>, FI-00029 Helsinki,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="1"><nlm:aff id="a107"><institution>Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kibriya, Muhammad G" sort="Kibriya, Muhammad G" uniqKey="Kibriya M" first="Muhammad G." last="Kibriya">Muhammad G. Kibriya</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Health Studies, The University of Chicago</institution>, Chicago, Illinois 60637,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation wicri:level="1"><nlm:aff id="a108"><institution>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>, Toronto, Ontario,<country>Canada</country> M5G 1X5</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name><affiliation wicri:level="1"><nlm:aff id="a109"><institution>Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus</institution>, 53113 Bonn,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Konstantopoulou, Irene" sort="Konstantopoulou, Irene" uniqKey="Konstantopoulou I" first="Irene" last="Konstantopoulou">Irene Konstantopoulou</name><affiliation wicri:level="1"><nlm:aff id="a66"><institution>Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research ‘Demokritos', Aghia Paraskevi Attikis</institution>, 15310 Athens,<country>Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation wicri:level="1"><nlm:aff id="a110"><institution>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland</institution>, FI-70211 Kuopio,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet</institution>, N-0310 Oslo,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kwong, Ava" sort="Kwong, Ava" uniqKey="Kwong A" first="Ava" last="Kwong">Ava Kwong</name><affiliation wicri:level="1"><nlm:aff id="a111"><institution>The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital</institution>, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>, Box 279, Hills Road</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a112"><institution>Department of Surgery, The University of Hong Kong</institution>, Hong Kong,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name><affiliation wicri:level="1"><nlm:aff id="a69"><institution>Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center</institution>, Tel-Hashomer 52621,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation wicri:level="1"><nlm:aff id="a113"><institution>Vesalius Research Center, VIB</institution>, 3000 Leuven,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lazaro, Conxi" sort="Lazaro, Conxi" uniqKey="Lazaro C" first="Conxi" last="Lazaro">Conxi Lazaro</name><affiliation wicri:level="1"><nlm:aff id="a114"><institution>Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology</institution>, 08908 Barcelona,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Eunjung" sort="Lee, Eunjung" uniqKey="Lee E" first="Eunjung" last="Lee">Eunjung Lee</name><affiliation wicri:level="1"><nlm:aff id="a115"><institution>Department of Preventive Medicine, University of Southern California</institution>, Los Angeles, California 90032,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="1"><nlm:aff id="a116"><institution>Cancer Epidemiology Program, University of Cancer Center</institution>, Honolulu, Hawaii 96813,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lester, Jenny" sort="Lester, Jenny" uniqKey="Lester J" first="Jenny" last="Lester">Jenny Lester</name><affiliation wicri:level="1"><nlm:aff id="a105"><institution>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center</institution>, Los Angeles, California, 90048,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation wicri:level="1"><nlm:aff id="a117"><institution>Department of Molecular Medicine and Surgery, Karolinska Institutet</institution>, SE-17177 Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lindor, Noralane" sort="Lindor, Noralane" uniqKey="Lindor N" first="Noralane" last="Lindor">Noralane Lindor</name><affiliation wicri:level="1"><nlm:aff id="a118"><institution>Health Sciences Research, Mayo Clinic</institution>, Scotsdale, Arizona 85259,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name><affiliation wicri:level="1"><nlm:aff id="a62"><institution>Department of Epidemiology, Harvard School of Public Health</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a119"><institution>Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation wicri:level="1"><nlm:aff id="a120"><institution>Human Genetics Division, Genome Institute of Singapore</institution>, Singapore 138672,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation wicri:level="1"><nlm:aff id="a121"><institution>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>, Nashville, Tennessee 37203,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation wicri:level="1"><nlm:aff id="a83"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L." last="Mai">Phuong L. Mai</name><affiliation wicri:level="1"><nlm:aff id="a82"><institution>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</institution>, Rockville, Maryland 20850-9772,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><affiliation wicri:level="1"><nlm:aff id="a95"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne</institution>, Melbourne, Victoria 3010,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Malone, Kathleen E" sort="Malone, Kathleen E" uniqKey="Malone K" first="Kathleen E." last="Malone">Kathleen E. Malone</name><affiliation wicri:level="1"><nlm:aff id="a122"><institution>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center</institution>, Seattle, Washington 98109,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a123"><institution>Department of Epidemiology, School of Public Health and Community Medicine, University of Washington</institution>, Seattle, Washington 98195,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation wicri:level="1"><nlm:aff id="a110"><institution>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland</institution>, FI-70211 Kuopio,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation wicri:level="1"><nlm:aff id="a124"><institution>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT)</institution>, 20133 Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation wicri:level="1"><nlm:aff id="a17"><institution>Department of Oncology, Karolinska University Hospital</institution>, SE-17176 Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation wicri:level="1"><nlm:aff id="a32"><institution>Department of Obstetrics and Gynecology, University of Heidelberg</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Martens, John W M" sort="Martens, John W M" uniqKey="Martens J" first="John W. M." last="Martens">John W. M. Martens</name><affiliation wicri:level="1"><nlm:aff id="a93"><institution>Department of Medical Oncology, Erasmus MC Cancer Institute</institution>, Rotterdam 3008 AE,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation wicri:level="1"><nlm:aff id="a125"><institution>Department of Gynaecology and Obstetrics, Technical University of Munich</institution>, 81675 Munich,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Miller, Austin" sort="Miller, Austin" uniqKey="Miller A" first="Austin" last="Miller">Austin Miller</name><affiliation wicri:level="1"><nlm:aff id="a126"><institution>NRG Oncology Statistics and Data Management Center, Roswell Park Cancer Institute</institution>, Buffalo, New York 14263,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation wicri:level="1"><nlm:aff id="a76"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>, Melbourne, Victoria 3010,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Miron, Penelope" sort="Miron, Penelope" uniqKey="Miron P" first="Penelope" last="Miron">Penelope Miron</name><affiliation wicri:level="1"><nlm:aff id="a127"><institution>Department of Genomics and Genome Sciences, Case Western Reserve University Medical School</institution>, Cleveland, Ohio 44106,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV—IRCCS</institution>, 20133 Padua,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name><affiliation wicri:level="1"><nlm:aff id="a46"><institution>INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon</institution>, 69373 Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mulligan, Anna M" sort="Mulligan, Anna M" uniqKey="Mulligan A" first="Anna M." last="Mulligan">Anna M. Mulligan</name><affiliation wicri:level="1"><nlm:aff id="a128"><institution>Laboratory Medicine Program, University Health Network</institution>, Toronto, Ontario,<country>Canada</country> M5B 1W8</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a129"><institution>Department of Laboratory Medicine and Pathobiology, University of Toronto</institution>, Toronto, Ontario,<country>Canada</country> M5B 1W8</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name><affiliation wicri:level="1"><nlm:aff id="a32"><institution>Department of Obstetrics and Gynecology, University of Heidelberg</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a90"><institution>Helsinki University Central Hospital</institution>, FI-00029 Helsinki,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><affiliation wicri:level="1"><nlm:aff id="a51"><institution>Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania</institution>, Pennsylvania 19104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation wicri:level="1"><nlm:aff id="a49"><institution>Department of Population Sciences, Beckman Research Institute of City of Hope</institution>, Duarte, California 91010,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation wicri:level="1"><nlm:aff id="a106"><institution>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital</institution>, FI-00029 Helsinki,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation wicri:level="1"><nlm:aff id="a28"><institution>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital</institution>, 2730 Herlev,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nussbaum, Robert L" sort="Nussbaum, Robert L" uniqKey="Nussbaum R" first="Robert L." last="Nussbaum">Robert L. Nussbaum</name><affiliation wicri:level="1"><nlm:aff id="a130"><institution>Invitae Corporation</institution>, San Francisco, California 94107,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation wicri:level="1"><nlm:aff id="a131"><institution>Department of Medicine, Memorial Sloan-Kettering Cancer Center</institution>, New York, New York 10065,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name><affiliation wicri:level="1"><nlm:aff id="a132"><institution>Department of Molecular Genetics, National Institute of Oncology</institution>, H-1122 Budapest,<country>Hungary</country></nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I." last="Olopade">Olufunmilayo I. Olopade</name><affiliation wicri:level="1"><nlm:aff id="a133"><institution>Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center</institution>, Chicago, Illinois 60637,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, Minnesota 55905,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name><affiliation wicri:level="1"><nlm:aff id="a22"><institution>Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO)</institution>, 28029 Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Park, Sue K" sort="Park, Sue K" uniqKey="Park S" first="Sue K." last="Park">Sue K. Park</name><affiliation wicri:level="1"><nlm:aff id="a134"><institution>Department of Preventive Medicine and Biomedical Science, Seoul National University College of Medicine and Cancer Research Institute, Seoul National University</institution>, 110-799 Seoul,<country>Republic of Korea</country></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name><affiliation wicri:level="1"><nlm:aff id="a135"><institution>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center</institution>, Utrecht 3508 GA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a136"><institution>MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</institution>, London SW7 2AZ,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peissel, Bernard" sort="Peissel, Bernard" uniqKey="Peissel B" first="Bernard" last="Peissel">Bernard Peissel</name><affiliation wicri:level="1"><nlm:aff id="a124"><institution>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT)</institution>, 20133 Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation wicri:level="1"><nlm:aff id="a137"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>, 20133 Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation wicri:level="1"><nlm:aff id="a53"><institution>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine</institution>, London, WC1E 7HT,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Phelan, Catherine M" sort="Phelan, Catherine M" uniqKey="Phelan C" first="Catherine M." last="Phelan">Catherine M. Phelan</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute</institution>, Tampa, Florida 33612,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pilarski, Robert" sort="Pilarski, Robert" uniqKey="Pilarski R" first="Robert" last="Pilarski">Robert Pilarski</name><affiliation wicri:level="1"><nlm:aff id="a138"><institution>Divison of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University</institution>, Columbus, Ohio 43210,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Poppe, Bruce" sort="Poppe, Bruce" uniqKey="Poppe B" first="Bruce" last="Poppe">Bruce Poppe</name><affiliation wicri:level="1"><nlm:aff id="a41"><institution>Center for Medical Genetics, Ghent University</institution>, 9000 Ghent,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation wicri:level="1"><nlm:aff id="a139"><institution>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu/Oulu University Hospital</institution>, FI-90220 Oulu,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation wicri:level="1"><nlm:aff id="a140"><institution>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT)</institution>, 20133 Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation wicri:level="1"><nlm:aff id="a141"><institution>Section of Cancer Genetics, Institute of Cancer Research</institution>, Sutton SM2 5NG,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rantala, Johanna" sort="Rantala, Johanna" uniqKey="Rantala J" first="Johanna" last="Rantala">Johanna Rantala</name><affiliation wicri:level="1"><nlm:aff id="a142"><institution>Department of Clinical Genetics, Karolinska University Hospital</institution>, SE-17176 Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rappaport, Christine" sort="Rappaport, Christine" uniqKey="Rappaport C" first="Christine" last="Rappaport">Christine Rappaport</name><affiliation wicri:level="1"><nlm:aff id="a143"><institution>Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna</institution>, A 1090 Vienna,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation wicri:level="1"><nlm:aff id="a144"><institution>Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine</institution>, Haifa 34362,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Richardson, Andrea" sort="Richardson, Andrea" uniqKey="Richardson A" first="Andrea" last="Richardson">Andrea Richardson</name><affiliation wicri:level="1"><nlm:aff id="a145"><institution>Department of Pathology, Johns Hopkins University School of Medicine</institution>, Baltimore, Maryland, 21205,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Robson, Mark" sort="Robson, Mark" uniqKey="Robson M" first="Mark" last="Robson">Mark Robson</name><affiliation wicri:level="1"><nlm:aff id="a131"><institution>Department of Medicine, Memorial Sloan-Kettering Cancer Center</institution>, New York, New York 10065,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Romieu, Isabelle" sort="Romieu, Isabelle" uniqKey="Romieu I" first="Isabelle" last="Romieu">Isabelle Romieu</name><affiliation wicri:level="1"><nlm:aff id="a146"><institution>International Agency for Research on Cancer</institution>, 69008 Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation wicri:level="1"><nlm:aff id="a38"><institution>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rutgers, Emiel J" sort="Rutgers, Emiel J" uniqKey="Rutgers E" first="Emiel J." last="Rutgers">Emiel J. Rutgers</name><affiliation wicri:level="1"><nlm:aff id="a147"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>, Amsterdam 1006 BE,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="Maria-Jose" last="Sanchez">Maria-Jose Sanchez</name><affiliation wicri:level="1"><nlm:aff id="a148"><institution>Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada/Universidad de Granada</institution>, 18014 Granada,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a149"><institution>CIBER de Epidemiología y Salud Pública (CIBERESP)</institution>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Santella, Regina M" sort="Santella, Regina M" uniqKey="Santella R" first="Regina M." last="Santella">Regina M. Santella</name><affiliation wicri:level="1"><nlm:aff id="a150"><institution>Department of Environmental Health Sciences, Columbia University</institution>, New York, New York, 10032,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name><affiliation wicri:level="1"><nlm:aff id="a151"><institution>Research Oncology, Division of Cancer Studies, King's College London, Guy's Hospital</institution>, London SE1 9RT,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F." last="Schmidt">Daniel F. Schmidt</name><affiliation wicri:level="1"><nlm:aff id="a95"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne</institution>, Melbourne, Victoria 3010,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation wicri:level="1"><nlm:aff id="a147"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>, Amsterdam 1006 BE,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation wicri:level="1"><nlm:aff id="a152"><institution>Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne</institution>, Cologne 50931,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a153"><institution>Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne</institution>, 50931 Cologne,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a154"><institution>Center for Molecular Medicine Cologne (CMMC), University of Cologne</institution>, 50931 Cologne,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name><affiliation wicri:level="1"><nlm:aff id="a86"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center</institution>, Los Angeles, California 90033,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Scott, Rodney" sort="Scott, Rodney" uniqKey="Scott R" first="Rodney" last="Scott">Rodney Scott</name><affiliation wicri:level="1"><nlm:aff id="a155"><institution>Division of Genetics, Hunter Area Pathology Service, John Hunter Hospital</institution>, Newcastle, New South Wales 2305,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Senter, Leigha" sort="Senter, Leigha" uniqKey="Senter L" first="Leigha" last="Senter">Leigha Senter</name><affiliation wicri:level="1"><nlm:aff id="a138"><institution>Divison of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University</institution>, Columbus, Ohio 43210,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sharma, Priyanka" sort="Sharma, Priyanka" uniqKey="Sharma P" first="Priyanka" last="Sharma">Priyanka Sharma</name><affiliation wicri:level="1"><nlm:aff id="a156"><institution>Department of Hematology and Oncology, University of Kansas Medical Center</institution>, Kansas City, Kansas 66205,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation wicri:level="1"><nlm:aff id="a157"><institution>Centre Hospitalier Universitaire de Québec Research Center, Laval University</institution>, Quebec City, Quebec,<country>Canada</country> G1V 4G2</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Singer, Christian F" sort="Singer, Christian F" uniqKey="Singer C" first="Christian F." last="Singer">Christian F. Singer</name><affiliation wicri:level="1"><nlm:aff id="a143"><institution>Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna</institution>, A 1090 Vienna,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name><affiliation wicri:level="1"><nlm:aff id="a46"><institution>INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon</institution>, 69373 Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a158"><institution>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon—Centre Léon Bérard</institution>, 69373 Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation wicri:level="1"><nlm:aff id="a157"><institution>Centre Hospitalier Universitaire de Québec Research Center, Laval University</institution>, Quebec City, Quebec,<country>Canada</country> G1V 4G2</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Southey, Melissa" sort="Southey, Melissa" uniqKey="Southey M" first="Melissa" last="Southey">Melissa Southey</name><affiliation wicri:level="1"><nlm:aff id="a159"><institution>Department of Pathology, The University of Melbourne</institution>, Melbourne, Victoria,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Steinemann, Doris" sort="Steinemann, Doris" uniqKey="Steinemann D" first="Doris" last="Steinemann">Doris Steinemann</name><affiliation wicri:level="1"><nlm:aff id="a160"><institution>Hannover Medical School</institution>, 30625 Hannover,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stenmark Askmalm, Marie" sort="Stenmark Askmalm, Marie" uniqKey="Stenmark Askmalm M" first="Marie" last="Stenmark-Askmalm">Marie Stenmark-Askmalm</name><affiliation wicri:level="1"><nlm:aff id="a161"><institution>Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University</institution>, SE-58185 Linköping,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation wicri:level="1"><nlm:aff id="a162"><institution>Institut Curie, Department of Tumour Biology</institution>, 75248 Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a163"><institution>Université Paris Descartes, Sorbonne Paris Cité</institution>, 75248 Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation wicri:level="1"><nlm:aff id="a104"><institution>Division of Genetics and Epidemiology, Institute of Cancer Research</institution>, Sutton SM2 5NG,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I." last="Szabo">Csilla I. Szabo</name><affiliation wicri:level="1"><nlm:aff id="a164"><institution>National Human Genome Research Institute, National Institutes of Health</institution>, Bethesda, Maryland 20892-2152,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tamimi, Rulla" sort="Tamimi, Rulla" uniqKey="Tamimi R" first="Rulla" last="Tamimi">Rulla Tamimi</name><affiliation wicri:level="1"><nlm:aff id="a61"><institution>Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a62"><institution>Department of Epidemiology, Harvard School of Public Health</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a119"><institution>Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tapper, William" sort="Tapper, William" uniqKey="Tapper W" first="William" last="Tapper">William Tapper</name><affiliation wicri:level="1"><nlm:aff id="a56"><institution>Faculty of Medicine, University of Southampton, University Hospital Southampton</institution>, Southampton, Hampshire SO16 6YD,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Teixeira, Manuel R" sort="Teixeira, Manuel R" uniqKey="Teixeira M" first="Manuel R." last="Teixeira">Manuel R. Teixeira</name><affiliation wicri:level="1"><nlm:aff id="a165"><institution>Department of Genetics, Portuguese Oncology Institute</institution>, Porto, 4200-072,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a166"><institution>Biomedical Sciences Institute (ICBAS), Porto University</institution>, 4200-072 Porto,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo-Hwang" last="Teo">Soo-Hwang Teo</name><affiliation wicri:level="1"><nlm:aff id="a167"><institution>Cancer Research Initiatives Foundation, Sime Darby Medical Centre</institution>, Subang Jaya 47500,<country>Malaysia</country></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a168"><institution>University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya</institution>, Kuala Lumpur 50603,<country>Malaysia</country></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Terry, Mary B" sort="Terry, Mary B" uniqKey="Terry M" first="Mary B." last="Terry">Mary B. Terry</name><affiliation wicri:level="1"><nlm:aff id="a169"><institution>Department of Epidemiology, Mailman School of Public Health, Columbia University</institution>, New York, New York, 10032,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name><affiliation wicri:level="1"><nlm:aff id="a170"><institution>Department of Clinical Genetics, Odense University Hospital</institution>, 5000 Odense C,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thompson, Deborah" sort="Thompson, Deborah" uniqKey="Thompson D" first="Deborah" last="Thompson">Deborah Thompson</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tihomirova, Laima" sort="Tihomirova, Laima" uniqKey="Tihomirova L" first="Laima" last="Tihomirova">Laima Tihomirova</name><affiliation wicri:level="1"><nlm:aff id="a171"><institution>Latvian Biomedical Research and Study Centre</institution>, LV-1067 Riga,<country>Latvia</country></nlm:aff><country xml:lang="fr">Lettonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name><affiliation wicri:level="1"><nlm:aff id="a172"><institution>Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University</institution>, Columbus, Ohio, 43210,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name><affiliation wicri:level="1"><nlm:aff id="a173"><institution>Department of Surgical Oncology, Leiden University Medical Center</institution>, Leiden 2333 ZC,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation wicri:level="1"><nlm:aff id="a174"><institution>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford</institution>, Oxford OX3 7BN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation wicri:level="1"><nlm:aff id="a84"><institution>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer</institution>, 70-115 Villejuif,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tsimiklis, Helen" sort="Tsimiklis, Helen" uniqKey="Tsimiklis H" first="Helen" last="Tsimiklis">Helen Tsimiklis</name><affiliation wicri:level="1"><nlm:aff id="a159"><institution>Department of Pathology, The University of Melbourne</institution>, Melbourne, Victoria,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Teule, Alex" sort="Teule, Alex" uniqKey="Teule A" first="Alex" last="Teulé">Alex Teulé</name><affiliation wicri:level="1"><nlm:aff id="a175"><institution>Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology</institution>, 08908 Barcelona,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tumino, Rosario" sort="Tumino, Rosario" uniqKey="Tumino R" first="Rosario" last="Tumino">Rosario Tumino</name><affiliation wicri:level="1"><nlm:aff id="a176"><institution>Cancer Registry and Histopathology Unit, ‘Civic—M.P. Arezzo' Hospital</institution>, 97100 ASP Ragusa,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tung, Nadine" sort="Tung, Nadine" uniqKey="Tung N" first="Nadine" last="Tung">Nadine Tung</name><affiliation wicri:level="1"><nlm:aff id="a177"><institution>Department of Medical Oncology, Beth Israel Deaconess Medical Center</institution>, Boston, Massachusetts, 02215,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name><affiliation wicri:level="1"><nlm:aff id="a141"><institution>Section of Cancer Genetics, Institute of Cancer Research</institution>, Sutton SM2 5NG,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ursin, Giski" sort="Ursin, Giski" uniqKey="Ursin G" first="Giski" last="Ursin">Giski Ursin</name><affiliation wicri:level="1"><nlm:aff id="a178"><institution>Cancer Registry of Norway, Institute of Population-Based Cancer Research</institution>, N-0304 Oslo,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Deurzen, Carolien H M" sort="Van Deurzen, Carolien H M" uniqKey="Van Deurzen C" first="Carolien H. M." last="Van Deurzen">Carolien H. M. Van Deurzen</name><affiliation wicri:level="1"><nlm:aff id="a179"><institution>Department of Pathology, Family Cancer Clinic, Erasmus University Medical Center</institution>, Rotterdam 3000 CA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Rensburg, Elizabeth J" sort="Van Rensburg, Elizabeth J" uniqKey="Van Rensburg E" first="Elizabeth J." last="Van Rensburg">Elizabeth J. Van Rensburg</name><affiliation wicri:level="1"><nlm:aff id="a52"><institution>Department of Genetics, University of Pretoria</institution>, Pretoria 0007,<country>South Africa</country></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Varon Mateeva, Raymonda" sort="Varon Mateeva, Raymonda" uniqKey="Varon Mateeva R" first="Raymonda" last="Varon-Mateeva">Raymonda Varon-Mateeva</name><affiliation wicri:level="1"><nlm:aff id="a180"><institution>Institute of Human Genetics, Charite Berlin</institution>, 13353 Berlin,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation wicri:level="1"><nlm:aff id="a181"><institution>Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>, Gaithersburg, Maryland 20877,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name><affiliation wicri:level="1"><nlm:aff id="a182"><institution>University Hospital Ulm</institution>, 89075 Ulm, ,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation wicri:level="1"><nlm:aff id="a44"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, SE-17177 Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a178"><institution>Cancer Registry of Norway, Institute of Population-Based Cancer Research</institution>, N-0304 Oslo,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a183"><institution>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø—The Arctic University of Norway</institution>, 9037 Tromsø,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a184"><institution>Genetic Epidemiology Group, Folkhälsan Research Center</institution>, 2016 Helsinki,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Weitzel, Jeffrey N" sort="Weitzel, Jeffrey N" uniqKey="Weitzel J" first="Jeffrey N." last="Weitzel">Jeffrey N. Weitzel</name><affiliation wicri:level="1"><nlm:aff id="a91"><institution>Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network</institution>, Duarte, California 91010,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Whittemore, Alice" sort="Whittemore, Alice" uniqKey="Whittemore A" first="Alice" last="Whittemore">Alice Whittemore</name><affiliation wicri:level="1"><nlm:aff id="a185"><institution>Department of Health Research and Policy—Epidemiology, Stanford University School of Medicine</institution>, Stanford, California 94305,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wildiers, Hans" sort="Wildiers, Hans" uniqKey="Wildiers H" first="Hans" last="Wildiers">Hans Wildiers</name><affiliation wicri:level="1"><nlm:aff id="a186"><institution>Multidisciplinary Breast Center, Department of General Medical Oncology, University Hospitals</institution>, B-3000 Leuven,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation wicri:level="1"><nlm:aff id="a139"><institution>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu/Oulu University Hospital</institution>, FI-90220 Oulu,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Xiaohong R" sort="Yang, Xiaohong R" uniqKey="Yang X" first="Xiaohong R." last="Yang">Xiaohong R. Yang</name><affiliation wicri:level="1"><nlm:aff id="a187"><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>, Bethesda, Maryland 20892,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name><affiliation wicri:level="1"><nlm:aff id="a66"><institution>Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research ‘Demokritos', Aghia Paraskevi Attikis</institution>, 15310 Athens,<country>Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yao, Song" sort="Yao, Song" uniqKey="Yao S" first="Song" last="Yao">Song Yao</name><affiliation wicri:level="1"><nlm:aff id="a11"><institution>Department of Cancer Prevention and Control, Roswell Park Cancer Institute</institution>, Buffalo, New York 14263,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M Pilar" last="Zamora">M Pilar Zamora</name><affiliation wicri:level="1"><nlm:aff id="a188"><institution>Servicio de Oncología Médica, Hospital Universitario La Paz</institution>, 28046 Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation wicri:level="1"><nlm:aff id="a121"><institution>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>, Nashville, Tennessee 37203,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation wicri:level="1"><nlm:aff id="a44"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, SE-17177 Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation wicri:level="1"><nlm:aff id="a62"><institution>Department of Epidemiology, Harvard School of Public Health</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a119"><institution>Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a189"><institution>Department of Biostatistics, Harvard School Of Public Health</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, Minnesota 55905,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Slager, Susan" sort="Slager, Susan" uniqKey="Slager S" first="Susan" last="Slager">Susan Slager</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, Minnesota 55905,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation wicri:level="1"><nlm:aff id="a190"><institution>Cancer Division, QIMR Berghofer Medical Research Institute</institution>, Brisbane, Queensland 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation wicri:level="1"><nlm:aff id="a55"><institution>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Monteiro, Alvaro A N" sort="Monteiro, Alvaro A N" uniqKey="Monteiro A" first="Alvaro A. N." last="Monteiro">Alvaro A. N. Monteiro</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute</institution>, Tampa, Florida 33612,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation wicri:level="1"><nlm:aff id="a191"><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</institution>, Rockville, Maryland 20850,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27117709</idno><idno type="pmc">4853421</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853421</idno><idno type="RBID">PMC:4853421</idno><idno type="doi">10.1038/ncomms11375</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000768</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000768</idno><idno type="wicri:Area/Pmc/Curation">000767</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000767</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer</title><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution>, Rochester, Minnesota 55905,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, Minnesota 55905,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kuchenbaecker, Karoline B" sort="Kuchenbaecker, Karoline B" uniqKey="Kuchenbaecker K" first="Karoline B." last="Kuchenbaecker">Karoline B. Kuchenbaecker</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mendoza Fandino, Gustavo A" sort="Mendoza Fandino, Gustavo A" uniqKey="Mendoza Fandino G" first="Gustavo A." last="Mendoza-Fandino">Gustavo A. Mendoza-Fandino</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute</institution>, Tampa, Florida 33612,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nord, Silje" sort="Nord, Silje" uniqKey="Nord S" first="Silje" last="Nord">Silje Nord</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet</institution>, N-0310 Oslo,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lilyquist, Janna" sort="Lilyquist, Janna" uniqKey="Lilyquist J" first="Janna" last="Lilyquist">Janna Lilyquist</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, Minnesota 55905,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Olswold, Curtis" sort="Olswold, Curtis" uniqKey="Olswold C" first="Curtis" last="Olswold">Curtis Olswold</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, Minnesota 55905,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hallberg, Emily" sort="Hallberg, Emily" uniqKey="Hallberg E" first="Emily" last="Hallberg">Emily Hallberg</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, Minnesota 55905,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Agata, Simona" sort="Agata, Simona" uniqKey="Agata S" first="Simona" last="Agata">Simona Agata</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV—IRCCS</institution>, 20133 Padua,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ahsan, Habibul" sort="Ahsan, Habibul" uniqKey="Ahsan H" first="Habibul" last="Ahsan">Habibul Ahsan</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Health Studies, The University of Chicago</institution>, Chicago, Illinois 60637,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Comprehensive Cancer Center, The University of Chicago</institution>, Chicago, Illinois 60637,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a9"><institution>Departments of Medicine and Human Genetics, The University of Chicago</institution>, Chicago, Illinois 60637,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation wicri:level="1"><nlm:aff id="a10"><institution>Department of Clinical Genetics, Helsinki University Central Hospital</institution>, 00029 Helsinki,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ambrosone, Christine" sort="Ambrosone, Christine" uniqKey="Ambrosone C" first="Christine" last="Ambrosone">Christine Ambrosone</name><affiliation wicri:level="1"><nlm:aff id="a11"><institution>Department of Cancer Prevention and Control, Roswell Park Cancer Institute</institution>, Buffalo, New York 14263,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation wicri:level="1"><nlm:aff id="a12"><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>, Toronto, Ontario,<country>Canada</country> M5G 1X5</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a13"><institution>Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto</institution>, Ontario,<country>Canada</country> M5B 1W8</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation wicri:level="1"><nlm:aff id="a14"><institution>Department of Epidemiology, University of California Irvine</institution>, Irvine, California, 92697,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation wicri:level="1"><nlm:aff id="a15"><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Arun, Banu K" sort="Arun, Banu K" uniqKey="Arun B" first="Banu K." last="Arun">Banu K. Arun</name><affiliation wicri:level="1"><nlm:aff id="a16"><institution>University of Texas MD Anderson Cancer Center</institution>, Houston, Texas 77030,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Arver, Brita" sort="Arver, Brita" uniqKey="Arver B" first="Brita" last="Arver">Brita Arver</name><affiliation wicri:level="1"><nlm:aff id="a17"><institution>Department of Oncology, Karolinska University Hospital</institution>, SE-17176 Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barile, Monica" sort="Barile, Monica" uniqKey="Barile M" first="Monica" last="Barile">Monica Barile</name><affiliation wicri:level="1"><nlm:aff id="a18"><institution>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia</institution>, 20141 Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barkardottir, Rosa B" sort="Barkardottir, Rosa B" uniqKey="Barkardottir R" first="Rosa B." last="Barkardottir">Rosa B. Barkardottir</name><affiliation wicri:level="1"><nlm:aff id="a19"><institution>Department of Pathology, Landspitali University Hospital and University of Iceland School of Medicine</institution>, 101 Reykjavik,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barrowdale, Daniel" sort="Barrowdale, Daniel" uniqKey="Barrowdale D" first="Daniel" last="Barrowdale">Daniel Barrowdale</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Beckmann, Lars" sort="Beckmann, Lars" uniqKey="Beckmann L" first="Lars" last="Beckmann">Lars Beckmann</name><affiliation wicri:level="1"><nlm:aff id="a20"><institution>Institute for Quality and Efficiency in Health Care (IQWiG)</institution>, 50670 Cologne,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation wicri:level="1"><nlm:aff id="a21"><institution>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN</institution>, 91054 Erlangen,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation wicri:level="1"><nlm:aff id="a22"><institution>Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO)</institution>, 28029 Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a23"><institution>Genotyping Unit (CeGen), Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO)</institution>, 28029 Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a24"><institution>Biomedical Network on Rare Diseases (CIBERER)</institution>, 28029 Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blank, Stephanie V" sort="Blank, Stephanie V" uniqKey="Blank S" first="Stephanie V." last="Blank">Stephanie V. Blank</name><affiliation wicri:level="1"><nlm:aff id="a25"><institution>NYU Women's Cancer Program, New York University School of Medicine</institution>, New York, New York 10016,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation wicri:level="1"><nlm:aff id="a26"><institution>Department of Oncology, University of Helsinki and Helsinki University Central Hospital</institution>, FI-00029 Helsinki,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation wicri:level="1"><nlm:aff id="a27"><institution>Department of Radiation Oncology, Hannover Medical School</institution>, 30625 Hannover,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation wicri:level="1"><nlm:aff id="a28"><institution>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital</institution>, 2730 Herlev,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name><affiliation wicri:level="1"><nlm:aff id="a18"><institution>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia</institution>, 20141 Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation wicri:level="1"><nlm:aff id="a29"><institution>Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology</institution>, 70376 Stuttgart,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a30"><institution>University of Tübingen</institution> 72074 Tübingen,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="1"><nlm:aff id="a15"><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a31"><institution>Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT)</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation wicri:level="1"><nlm:aff id="a32"><institution>Department of Obstetrics and Gynecology, University of Heidelberg</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S." last="Buys">Saundra S. Buys</name><affiliation wicri:level="1"><nlm:aff id="a33"><institution>Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine</institution>, Salt Lake City Utah 84112,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name><affiliation wicri:level="1"><nlm:aff id="a34"><institution>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC</institution>, Madrid 28040,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A." last="Caligo">Maria A. Caligo</name><affiliation wicri:level="1"><nlm:aff id="a35"><institution>Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa</institution>, I-56126 Pisa,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name><affiliation wicri:level="1"><nlm:aff id="a36"><institution>Genomic Epidemiology Group, German Cancer Research Center (DKFZ)</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Carpenter, Jane" sort="Carpenter, Jane" uniqKey="Carpenter J" first="Jane" last="Carpenter">Jane Carpenter</name><affiliation wicri:level="1"><nlm:aff id="a37"><institution>Australian Breast Cancer Tissue Bank, Westmead Millennium Institute, University of Sydney</institution>, Sydney, New South Wales 2145,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation wicri:level="1"><nlm:aff id="a38"><institution>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="1"><nlm:aff id="a39"><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>, Rockville, Maryland 20850,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chung, Wendy K" sort="Chung, Wendy K" uniqKey="Chung W" first="Wendy K." last="Chung">Wendy K. Chung</name><affiliation wicri:level="1"><nlm:aff id="a40"><institution>Departments of Pediatrics and Medicine, Columbia University</institution>, New York, New York 10032,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Claes, Kathleen B M" sort="Claes, Kathleen B M" uniqKey="Claes K" first="Kathleen B. M." last="Claes">Kathleen B. M. Claes</name><affiliation wicri:level="1"><nlm:aff id="a41"><institution>Center for Medical Genetics, Ghent University</institution>, 9000 Ghent,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation wicri:level="1"><nlm:aff id="a42"><institution>Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield</institution>, Sheffield S10 2RX,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation wicri:level="1"><nlm:aff id="a43"><institution>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield</institution>, Sheffield S10 2HQ,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cunningham, Julie M" sort="Cunningham, Julie M" uniqKey="Cunningham J" first="Julie M." last="Cunningham">Julie M. Cunningham</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution>, Rochester, Minnesota 55905,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation wicri:level="1"><nlm:aff id="a44"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, SE-17177 Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B." last="Daly">Mary B. Daly</name><affiliation wicri:level="1"><nlm:aff id="a45"><institution>Department of Clinical Genetics, Fox Chase Cancer Center</institution>, Philadelphia, Pennsylvania 19111,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Damiola, Francesca" sort="Damiola, Francesca" uniqKey="Damiola F" first="Francesca" last="Damiola">Francesca Damiola</name><affiliation wicri:level="1"><nlm:aff id="a46"><institution>INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon</institution>, 69373 Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation wicri:level="1"><nlm:aff id="a44"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, SE-17177 Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De La Hoya, Miguel" sort="De La Hoya, Miguel" uniqKey="De La Hoya M" first="Miguel" last="De La Hoya">Miguel De La Hoya</name><affiliation wicri:level="1"><nlm:aff id="a34"><institution>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC</institution>, Madrid 28040,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation wicri:level="1"><nlm:aff id="a47"><institution>Department of Human Genetics and Department of Pathology, Leiden University Medical Center</institution>, Leiden 2333 ZC,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Diez, Orland" sort="Diez, Orland" uniqKey="Diez O" first="Orland" last="Diez">Orland Diez</name><affiliation wicri:level="1"><nlm:aff id="a48"><institution>Oncogenetics Group, University Hospital Vall d'Hebron, Vall d'Hebron Institute of Oncology (VHIO) and Universitat Autònoma de Barcelona</institution>, 08035 Barcelona,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ding, Yuan C" sort="Ding, Yuan C" uniqKey="Ding Y" first="Yuan C." last="Ding">Yuan C. Ding</name><affiliation wicri:level="1"><nlm:aff id="a49"><institution>Department of Population Sciences, Beckman Research Institute of City of Hope</institution>, Duarte, California 91010,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dolcetti, Riccardo" sort="Dolcetti, Riccardo" uniqKey="Dolcetti R" first="Riccardo" last="Dolcetti">Riccardo Dolcetti</name><affiliation wicri:level="1"><nlm:aff id="a50"><institution>Cancer Bioimmunotherapy Unit, CRO Aviano National Cancer Institute</institution>, 33081 Aviano ,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M." last="Domchek">Susan M. Domchek</name><affiliation wicri:level="1"><nlm:aff id="a51"><institution>Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania</institution>, Pennsylvania 19104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dorfling, Cecilia M" sort="Dorfling, Cecilia M" uniqKey="Dorfling C" first="Cecilia M." last="Dorfling">Cecilia M. Dorfling</name><affiliation wicri:level="1"><nlm:aff id="a52"><institution>Department of Genetics, University of Pretoria</institution>, Pretoria 0007,<country>South Africa</country></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation wicri:level="1"><nlm:aff id="a53"><institution>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine</institution>, London, WC1E 7HT,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name><affiliation wicri:level="1"><nlm:aff id="a54"><institution>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University</institution>, Quebec City, Quebec,<country>Canada</country> G1V 4G2</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation wicri:level="1"><nlm:aff id="a55"><institution>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eccles, Diana M" sort="Eccles, Diana M" uniqKey="Eccles D" first="Diana M." last="Eccles">Diana M. Eccles</name><affiliation wicri:level="1"><nlm:aff id="a56"><institution>Faculty of Medicine, University of Southampton, University Hospital Southampton</institution>, Southampton, Hampshire SO16 6YD,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ehrencrona, Hans" sort="Ehrencrona, Hans" uniqKey="Ehrencrona H" first="Hans" last="Ehrencrona">Hans Ehrencrona</name><affiliation wicri:level="1"><nlm:aff id="a57"><institution>Department of Immunology, Genetics and Pathology, Uppsala University</institution>, Uppsala SE-751 85,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a58"><institution>Department of Clinical Genetics, Lund University Hospital</institution>, SE-22185 Lund,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation wicri:level="1"><nlm:aff id="a59"><institution>Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg</institution>, 91054 Erlangen,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a60"><institution>Comprehensive Cancer Center -EMN</institution>, 91054 Erlangen,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eliassen, Heather" sort="Eliassen, Heather" uniqKey="Eliassen H" first="Heather" last="Eliassen">Heather Eliassen</name><affiliation wicri:level="1"><nlm:aff id="a61"><institution>Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a62"><institution>Department of Epidemiology, Harvard School of Public Health</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ellis, Steve" sort="Ellis, Steve" uniqKey="Ellis S" first="Steve" last="Ellis">Steve Ellis</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation wicri:level="1"><nlm:aff id="a21"><institution>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN</institution>, 91054 Erlangen,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation wicri:level="1"><nlm:aff id="a39"><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>, Rockville, Maryland 20850,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation wicri:level="1"><nlm:aff id="a63"><institution>Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf</institution>, 20246 Hamburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Forsti, Asta" sort="Forsti, Asta" uniqKey="Forsti A" first="Asta" last="Försti">Asta Försti</name><affiliation wicri:level="1"><nlm:aff id="a64"><institution>Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ)</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a65"><institution>Center for Primary Health Care Research, Lund University</institution>, SE-221 00 Malmö,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fostira, Florentia" sort="Fostira, Florentia" uniqKey="Fostira F" first="Florentia" last="Fostira">Florentia Fostira</name><affiliation wicri:level="1"><nlm:aff id="a66"><institution>Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research ‘Demokritos', Aghia Paraskevi Attikis</institution>, 15310 Athens,<country>Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Foulkes, William D" sort="Foulkes, William D" uniqKey="Foulkes W" first="William D." last="Foulkes">William D. Foulkes</name><affiliation wicri:level="1"><nlm:aff id="a67"><institution>Program in Cancer Genetics, McGill University</institution>, Montreal, Quebec,<country>Canada</country> H3A 0G4</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Friebel, Tara" sort="Friebel, Tara" uniqKey="Friebel T" first="Tara" last="Friebel">Tara Friebel</name><affiliation wicri:level="1"><nlm:aff id="a68"><institution>University of</institution>, Philadelphia, Pennsylvania 19104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><affiliation wicri:level="1"><nlm:aff id="a69"><institution>Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center</institution>, Tel-Hashomer 52621,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gabrielson, Marike" sort="Gabrielson, Marike" uniqKey="Gabrielson M" first="Marike" last="Gabrielson">Marike Gabrielson</name><affiliation wicri:level="1"><nlm:aff id="a44"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, SE-17177 Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gammon, Marilie D" sort="Gammon, Marilie D" uniqKey="Gammon M" first="Marilie D." last="Gammon">Marilie D. Gammon</name><affiliation wicri:level="1"><nlm:aff id="a70"><institution>Department of Epidemiology, University of</institution>, Chapel Hill, North Carolina 27599-7400,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name><affiliation wicri:level="1"><nlm:aff id="a71"><institution>UCLA Schools of Medicine and Public Health, Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center</institution>, Los Angeles, California 90095-6900,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gapstur, Susan M" sort="Gapstur, Susan M" uniqKey="Gapstur S" first="Susan M." last="Gapstur">Susan M. Gapstur</name><affiliation wicri:level="1"><nlm:aff id="a72"><institution>Epidemiology Research Program, American Cancer Society</institution>, Atlanta, Georgia 30303,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Garber, Judy" sort="Garber, Judy" uniqKey="Garber J" first="Judy" last="Garber">Judy Garber</name><affiliation wicri:level="1"><nlm:aff id="a73"><institution>Cancer Risk and Prevention Clinic, Dana Farber Cancer Institute</institution>, Boston, Massachusetts 02215,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M." last="Gaudet">Mia M. Gaudet</name><affiliation wicri:level="1"><nlm:aff id="a72"><institution>Epidemiology Research Program, American Cancer Society</institution>, Atlanta, Georgia 30303,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gayther, Simon A" sort="Gayther, Simon A" uniqKey="Gayther S" first="Simon A." last="Gayther">Simon A. Gayther</name><affiliation wicri:level="1"><nlm:aff id="a74"><institution>Department of Biomedical Sciences, Cedars Sinai Medical Center</institution>, Los Angeles, California 90048,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gerdes, Anne Marie" sort="Gerdes, Anne Marie" uniqKey="Gerdes A" first="Anne-Marie" last="Gerdes">Anne-Marie Gerdes</name><affiliation wicri:level="1"><nlm:aff id="a75"><institution>Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital</institution>, DK-2100 Copenhagen,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name><affiliation wicri:level="1"><nlm:aff id="a55"><institution>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation wicri:level="1"><nlm:aff id="a76"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>, Melbourne, Victoria 3010,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation wicri:level="1"><nlm:aff id="a12"><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>, Toronto, Ontario,<country>Canada</country> M5G 1X5</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name><affiliation wicri:level="1"><nlm:aff id="a77"><institution>Department of Pathology and Laboratory Medicine, University of Kansas Medical Center</institution>, Kansas City, Kansas, 66205,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S." last="Goldberg">Mark S. Goldberg</name><affiliation wicri:level="1"><nlm:aff id="a78"><institution>Department of Medicine, McGill University</institution>, Montreal, Quebec,<country>Canada</country> H3G 2M1</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a79"><institution>Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital</institution>, Montreal, Quebec,<country>Canada</country> H4A 3J1</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E." last="Goldgar">David E. Goldgar</name><affiliation wicri:level="1"><nlm:aff id="a80"><institution>Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine</institution>, Salt Lake City, Utah 84132,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation wicri:level="1"><nlm:aff id="a81"><institution>Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)</institution>, 28029 Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><affiliation wicri:level="1"><nlm:aff id="a82"><institution>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</institution>, Rockville, Maryland 20850-9772,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name><affiliation wicri:level="1"><nlm:aff id="a83"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation wicri:level="1"><nlm:aff id="a84"><institution>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer</institution>, 70-115 Villejuif,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gunter, Marc" sort="Gunter, Marc" uniqKey="Gunter M" first="Marc" last="Gunter">Marc Gunter</name><affiliation wicri:level="1"><nlm:aff id="a85"><institution>Department of of Epidemiology and Biostatistics, School of Public Health, Imperial College London</institution>, London, SW7 2AZ,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haeberle, Lothar" sort="Haeberle, Lothar" uniqKey="Haeberle L" first="Lothar" last="Haeberle">Lothar Haeberle</name><affiliation wicri:level="1"><nlm:aff id="a21"><institution>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN</institution>, 91054 Erlangen,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="1"><nlm:aff id="a86"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center</institution>, Los Angeles, California 90033,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation wicri:level="1"><nlm:aff id="a87"><institution>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V. O." last="Hansen">Thomas V. O. Hansen</name><affiliation wicri:level="1"><nlm:aff id="a88"><institution>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital</institution>, DK-2100 Copenhagen,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hart, Steven" sort="Hart, Steven" uniqKey="Hart S" first="Steven" last="Hart">Steven Hart</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, Minnesota 55905,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name><affiliation wicri:level="1"><nlm:aff id="a89"><institution>Department of Genetics, QIMR Berghofer Medical Research Institute</institution>, Brisbane, Queensland 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Heikkinen, Tuomas" sort="Heikkinen, Tuomas" uniqKey="Heikkinen T" first="Tuomas" last="Heikkinen">Tuomas Heikkinen</name><affiliation wicri:level="1"><nlm:aff id="a32"><institution>Department of Obstetrics and Gynecology, University of Heidelberg</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a90"><institution>Helsinki University Central Hospital</institution>, FI-00029 Helsinki,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation wicri:level="1"><nlm:aff id="a86"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center</institution>, Los Angeles, California 90033,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Herzog, Josef" sort="Herzog, Josef" uniqKey="Herzog J" first="Josef" last="Herzog">Josef Herzog</name><affiliation wicri:level="1"><nlm:aff id="a91"><institution>Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network</institution>, Duarte, California 91010,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B. L." last="Hogervorst">Frans B. L. Hogervorst</name><affiliation wicri:level="1"><nlm:aff id="a92"><institution>Family Cancer Clinic, Netherlands Cancer Institute</institution>, Amsterdam 1000 BE,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation wicri:level="1"><nlm:aff id="a93"><institution>Department of Medical Oncology, Erasmus MC Cancer Institute</institution>, Rotterdam 3008 AE,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name><affiliation wicri:level="1"><nlm:aff id="a94"><institution>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center</institution>, Rotterdam 3008 AE,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N." last="Hoover">Robert N. Hoover</name><affiliation wicri:level="1"><nlm:aff id="a39"><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>, Rockville, Maryland 20850,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="1"><nlm:aff id="a95"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne</institution>, Melbourne, Victoria 3010,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name><affiliation wicri:level="1"><nlm:aff id="a44"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, SE-17177 Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation wicri:level="1"><nlm:aff id="a96"><institution>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huzarski, Tomasz" sort="Huzarski, Tomasz" uniqKey="Huzarski T" first="Tomasz" last="Huzarski">Tomasz Huzarski</name><affiliation wicri:level="1"><nlm:aff id="a83"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Imyanitov, Evgeny N" sort="Imyanitov, Evgeny N" uniqKey="Imyanitov E" first="Evgeny N." last="Imyanitov">Evgeny N. Imyanitov</name><affiliation wicri:level="1"><nlm:aff id="a97"><institution>N.N. Petrov Institute of Oncology</institution>, 197758 St Petersburg,<country>Russia</country></nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name><affiliation wicri:level="1"><nlm:aff id="a98"><institution>Lombardi Comprehensive Cancer Center, Georgetown University</institution>, Washington, DC 20007,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation wicri:level="1"><nlm:aff id="a83"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="James, Paul" sort="James, Paul" uniqKey="James P" first="Paul" last="James">Paul James</name><affiliation wicri:level="1"><nlm:aff id="a99"><institution>Familial Cancer Centre, Peter MacCallum Cancer Centre</institution>, Melbourne, Victoria 8006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a100"><institution>Department of Oncology, The University of Melbourne</institution>, Melbourne, Victoria 8006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Janavicius, Ramunas" sort="Janavicius, Ramunas" uniqKey="Janavicius R" first="Ramunas" last="Janavicius">Ramunas Janavicius</name><affiliation wicri:level="1"><nlm:aff id="a101"><institution>State Research Institute Centre for Innovative Medicine</institution>, LT-08661 Vilnius,<country>Lithuania</country></nlm:aff><country xml:lang="fr">Lituanie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jensen, Uffe Birk" sort="Jensen, Uffe Birk" uniqKey="Jensen U" first="Uffe Birk" last="Jensen">Uffe Birk Jensen</name><affiliation wicri:level="1"><nlm:aff id="a102"><institution>Department of Clinical Genetics, Aarhus University Hospital</institution>, 8200 Aarhus N,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name><affiliation wicri:level="1"><nlm:aff id="a103"><institution>Department of Epidemiology, Cancer Prevention Institute of California</institution>, Fremont, California 94538,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jones, Michael" sort="Jones, Michael" uniqKey="Jones M" first="Michael" last="Jones">Michael Jones</name><affiliation wicri:level="1"><nlm:aff id="a104"><institution>Division of Genetics and Epidemiology, Institute of Cancer Research</institution>, Sutton SM2 5NG,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kabisch, Maria" sort="Kabisch, Maria" uniqKey="Kabisch M" first="Maria" last="Kabisch">Maria Kabisch</name><affiliation wicri:level="1"><nlm:aff id="a87"><institution>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kar, Siddhartha" sort="Kar, Siddhartha" uniqKey="Kar S" first="Siddhartha" last="Kar">Siddhartha Kar</name><affiliation wicri:level="1"><nlm:aff id="a55"><institution>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y." last="Karlan">Beth Y. Karlan</name><affiliation wicri:level="1"><nlm:aff id="a105"><institution>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center</institution>, Los Angeles, California, 90048,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Khan, Sofia" sort="Khan, Sofia" uniqKey="Khan S" first="Sofia" last="Khan">Sofia Khan</name><affiliation wicri:level="1"><nlm:aff id="a106"><institution>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital</institution>, FI-00029 Helsinki,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="1"><nlm:aff id="a107"><institution>Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kibriya, Muhammad G" sort="Kibriya, Muhammad G" uniqKey="Kibriya M" first="Muhammad G." last="Kibriya">Muhammad G. Kibriya</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Health Studies, The University of Chicago</institution>, Chicago, Illinois 60637,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation wicri:level="1"><nlm:aff id="a108"><institution>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>, Toronto, Ontario,<country>Canada</country> M5G 1X5</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name><affiliation wicri:level="1"><nlm:aff id="a109"><institution>Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus</institution>, 53113 Bonn,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Konstantopoulou, Irene" sort="Konstantopoulou, Irene" uniqKey="Konstantopoulou I" first="Irene" last="Konstantopoulou">Irene Konstantopoulou</name><affiliation wicri:level="1"><nlm:aff id="a66"><institution>Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research ‘Demokritos', Aghia Paraskevi Attikis</institution>, 15310 Athens,<country>Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation wicri:level="1"><nlm:aff id="a110"><institution>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland</institution>, FI-70211 Kuopio,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet</institution>, N-0310 Oslo,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kwong, Ava" sort="Kwong, Ava" uniqKey="Kwong A" first="Ava" last="Kwong">Ava Kwong</name><affiliation wicri:level="1"><nlm:aff id="a111"><institution>The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital</institution>, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>, Box 279, Hills Road</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a112"><institution>Department of Surgery, The University of Hong Kong</institution>, Hong Kong,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name><affiliation wicri:level="1"><nlm:aff id="a69"><institution>Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center</institution>, Tel-Hashomer 52621,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation wicri:level="1"><nlm:aff id="a113"><institution>Vesalius Research Center, VIB</institution>, 3000 Leuven,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lazaro, Conxi" sort="Lazaro, Conxi" uniqKey="Lazaro C" first="Conxi" last="Lazaro">Conxi Lazaro</name><affiliation wicri:level="1"><nlm:aff id="a114"><institution>Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology</institution>, 08908 Barcelona,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Eunjung" sort="Lee, Eunjung" uniqKey="Lee E" first="Eunjung" last="Lee">Eunjung Lee</name><affiliation wicri:level="1"><nlm:aff id="a115"><institution>Department of Preventive Medicine, University of Southern California</institution>, Los Angeles, California 90032,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="1"><nlm:aff id="a116"><institution>Cancer Epidemiology Program, University of Cancer Center</institution>, Honolulu, Hawaii 96813,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lester, Jenny" sort="Lester, Jenny" uniqKey="Lester J" first="Jenny" last="Lester">Jenny Lester</name><affiliation wicri:level="1"><nlm:aff id="a105"><institution>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center</institution>, Los Angeles, California, 90048,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation wicri:level="1"><nlm:aff id="a117"><institution>Department of Molecular Medicine and Surgery, Karolinska Institutet</institution>, SE-17177 Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lindor, Noralane" sort="Lindor, Noralane" uniqKey="Lindor N" first="Noralane" last="Lindor">Noralane Lindor</name><affiliation wicri:level="1"><nlm:aff id="a118"><institution>Health Sciences Research, Mayo Clinic</institution>, Scotsdale, Arizona 85259,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name><affiliation wicri:level="1"><nlm:aff id="a62"><institution>Department of Epidemiology, Harvard School of Public Health</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a119"><institution>Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation wicri:level="1"><nlm:aff id="a120"><institution>Human Genetics Division, Genome Institute of Singapore</institution>, Singapore 138672,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation wicri:level="1"><nlm:aff id="a121"><institution>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>, Nashville, Tennessee 37203,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation wicri:level="1"><nlm:aff id="a83"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L." last="Mai">Phuong L. Mai</name><affiliation wicri:level="1"><nlm:aff id="a82"><institution>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</institution>, Rockville, Maryland 20850-9772,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><affiliation wicri:level="1"><nlm:aff id="a95"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne</institution>, Melbourne, Victoria 3010,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Malone, Kathleen E" sort="Malone, Kathleen E" uniqKey="Malone K" first="Kathleen E." last="Malone">Kathleen E. Malone</name><affiliation wicri:level="1"><nlm:aff id="a122"><institution>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center</institution>, Seattle, Washington 98109,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a123"><institution>Department of Epidemiology, School of Public Health and Community Medicine, University of Washington</institution>, Seattle, Washington 98195,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation wicri:level="1"><nlm:aff id="a110"><institution>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland</institution>, FI-70211 Kuopio,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation wicri:level="1"><nlm:aff id="a124"><institution>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT)</institution>, 20133 Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation wicri:level="1"><nlm:aff id="a17"><institution>Department of Oncology, Karolinska University Hospital</institution>, SE-17176 Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation wicri:level="1"><nlm:aff id="a32"><institution>Department of Obstetrics and Gynecology, University of Heidelberg</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Martens, John W M" sort="Martens, John W M" uniqKey="Martens J" first="John W. M." last="Martens">John W. M. Martens</name><affiliation wicri:level="1"><nlm:aff id="a93"><institution>Department of Medical Oncology, Erasmus MC Cancer Institute</institution>, Rotterdam 3008 AE,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation wicri:level="1"><nlm:aff id="a125"><institution>Department of Gynaecology and Obstetrics, Technical University of Munich</institution>, 81675 Munich,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Miller, Austin" sort="Miller, Austin" uniqKey="Miller A" first="Austin" last="Miller">Austin Miller</name><affiliation wicri:level="1"><nlm:aff id="a126"><institution>NRG Oncology Statistics and Data Management Center, Roswell Park Cancer Institute</institution>, Buffalo, New York 14263,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation wicri:level="1"><nlm:aff id="a76"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>, Melbourne, Victoria 3010,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Miron, Penelope" sort="Miron, Penelope" uniqKey="Miron P" first="Penelope" last="Miron">Penelope Miron</name><affiliation wicri:level="1"><nlm:aff id="a127"><institution>Department of Genomics and Genome Sciences, Case Western Reserve University Medical School</institution>, Cleveland, Ohio 44106,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV—IRCCS</institution>, 20133 Padua,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name><affiliation wicri:level="1"><nlm:aff id="a46"><institution>INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon</institution>, 69373 Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mulligan, Anna M" sort="Mulligan, Anna M" uniqKey="Mulligan A" first="Anna M." last="Mulligan">Anna M. Mulligan</name><affiliation wicri:level="1"><nlm:aff id="a128"><institution>Laboratory Medicine Program, University Health Network</institution>, Toronto, Ontario,<country>Canada</country> M5B 1W8</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a129"><institution>Department of Laboratory Medicine and Pathobiology, University of Toronto</institution>, Toronto, Ontario,<country>Canada</country> M5B 1W8</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name><affiliation wicri:level="1"><nlm:aff id="a32"><institution>Department of Obstetrics and Gynecology, University of Heidelberg</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a90"><institution>Helsinki University Central Hospital</institution>, FI-00029 Helsinki,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><affiliation wicri:level="1"><nlm:aff id="a51"><institution>Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania</institution>, Pennsylvania 19104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation wicri:level="1"><nlm:aff id="a49"><institution>Department of Population Sciences, Beckman Research Institute of City of Hope</institution>, Duarte, California 91010,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation wicri:level="1"><nlm:aff id="a106"><institution>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital</institution>, FI-00029 Helsinki,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation wicri:level="1"><nlm:aff id="a28"><institution>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital</institution>, 2730 Herlev,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nussbaum, Robert L" sort="Nussbaum, Robert L" uniqKey="Nussbaum R" first="Robert L." last="Nussbaum">Robert L. Nussbaum</name><affiliation wicri:level="1"><nlm:aff id="a130"><institution>Invitae Corporation</institution>, San Francisco, California 94107,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation wicri:level="1"><nlm:aff id="a131"><institution>Department of Medicine, Memorial Sloan-Kettering Cancer Center</institution>, New York, New York 10065,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name><affiliation wicri:level="1"><nlm:aff id="a132"><institution>Department of Molecular Genetics, National Institute of Oncology</institution>, H-1122 Budapest,<country>Hungary</country></nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I." last="Olopade">Olufunmilayo I. Olopade</name><affiliation wicri:level="1"><nlm:aff id="a133"><institution>Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center</institution>, Chicago, Illinois 60637,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, Minnesota 55905,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name><affiliation wicri:level="1"><nlm:aff id="a22"><institution>Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO)</institution>, 28029 Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Park, Sue K" sort="Park, Sue K" uniqKey="Park S" first="Sue K." last="Park">Sue K. Park</name><affiliation wicri:level="1"><nlm:aff id="a134"><institution>Department of Preventive Medicine and Biomedical Science, Seoul National University College of Medicine and Cancer Research Institute, Seoul National University</institution>, 110-799 Seoul,<country>Republic of Korea</country></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name><affiliation wicri:level="1"><nlm:aff id="a135"><institution>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center</institution>, Utrecht 3508 GA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a136"><institution>MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</institution>, London SW7 2AZ,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peissel, Bernard" sort="Peissel, Bernard" uniqKey="Peissel B" first="Bernard" last="Peissel">Bernard Peissel</name><affiliation wicri:level="1"><nlm:aff id="a124"><institution>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT)</institution>, 20133 Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation wicri:level="1"><nlm:aff id="a137"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>, 20133 Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation wicri:level="1"><nlm:aff id="a53"><institution>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine</institution>, London, WC1E 7HT,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Phelan, Catherine M" sort="Phelan, Catherine M" uniqKey="Phelan C" first="Catherine M." last="Phelan">Catherine M. Phelan</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute</institution>, Tampa, Florida 33612,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pilarski, Robert" sort="Pilarski, Robert" uniqKey="Pilarski R" first="Robert" last="Pilarski">Robert Pilarski</name><affiliation wicri:level="1"><nlm:aff id="a138"><institution>Divison of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University</institution>, Columbus, Ohio 43210,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Poppe, Bruce" sort="Poppe, Bruce" uniqKey="Poppe B" first="Bruce" last="Poppe">Bruce Poppe</name><affiliation wicri:level="1"><nlm:aff id="a41"><institution>Center for Medical Genetics, Ghent University</institution>, 9000 Ghent,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation wicri:level="1"><nlm:aff id="a139"><institution>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu/Oulu University Hospital</institution>, FI-90220 Oulu,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation wicri:level="1"><nlm:aff id="a140"><institution>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT)</institution>, 20133 Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation wicri:level="1"><nlm:aff id="a141"><institution>Section of Cancer Genetics, Institute of Cancer Research</institution>, Sutton SM2 5NG,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rantala, Johanna" sort="Rantala, Johanna" uniqKey="Rantala J" first="Johanna" last="Rantala">Johanna Rantala</name><affiliation wicri:level="1"><nlm:aff id="a142"><institution>Department of Clinical Genetics, Karolinska University Hospital</institution>, SE-17176 Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rappaport, Christine" sort="Rappaport, Christine" uniqKey="Rappaport C" first="Christine" last="Rappaport">Christine Rappaport</name><affiliation wicri:level="1"><nlm:aff id="a143"><institution>Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna</institution>, A 1090 Vienna,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation wicri:level="1"><nlm:aff id="a144"><institution>Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine</institution>, Haifa 34362,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Richardson, Andrea" sort="Richardson, Andrea" uniqKey="Richardson A" first="Andrea" last="Richardson">Andrea Richardson</name><affiliation wicri:level="1"><nlm:aff id="a145"><institution>Department of Pathology, Johns Hopkins University School of Medicine</institution>, Baltimore, Maryland, 21205,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Robson, Mark" sort="Robson, Mark" uniqKey="Robson M" first="Mark" last="Robson">Mark Robson</name><affiliation wicri:level="1"><nlm:aff id="a131"><institution>Department of Medicine, Memorial Sloan-Kettering Cancer Center</institution>, New York, New York 10065,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Romieu, Isabelle" sort="Romieu, Isabelle" uniqKey="Romieu I" first="Isabelle" last="Romieu">Isabelle Romieu</name><affiliation wicri:level="1"><nlm:aff id="a146"><institution>International Agency for Research on Cancer</institution>, 69008 Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation wicri:level="1"><nlm:aff id="a38"><institution>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)</institution>, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rutgers, Emiel J" sort="Rutgers, Emiel J" uniqKey="Rutgers E" first="Emiel J." last="Rutgers">Emiel J. Rutgers</name><affiliation wicri:level="1"><nlm:aff id="a147"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>, Amsterdam 1006 BE,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="Maria-Jose" last="Sanchez">Maria-Jose Sanchez</name><affiliation wicri:level="1"><nlm:aff id="a148"><institution>Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada/Universidad de Granada</institution>, 18014 Granada,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a149"><institution>CIBER de Epidemiología y Salud Pública (CIBERESP)</institution>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Santella, Regina M" sort="Santella, Regina M" uniqKey="Santella R" first="Regina M." last="Santella">Regina M. Santella</name><affiliation wicri:level="1"><nlm:aff id="a150"><institution>Department of Environmental Health Sciences, Columbia University</institution>, New York, New York, 10032,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name><affiliation wicri:level="1"><nlm:aff id="a151"><institution>Research Oncology, Division of Cancer Studies, King's College London, Guy's Hospital</institution>, London SE1 9RT,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F." last="Schmidt">Daniel F. Schmidt</name><affiliation wicri:level="1"><nlm:aff id="a95"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne</institution>, Melbourne, Victoria 3010,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation wicri:level="1"><nlm:aff id="a147"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>, Amsterdam 1006 BE,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation wicri:level="1"><nlm:aff id="a152"><institution>Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne</institution>, Cologne 50931,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a153"><institution>Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne</institution>, 50931 Cologne,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a154"><institution>Center for Molecular Medicine Cologne (CMMC), University of Cologne</institution>, 50931 Cologne,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name><affiliation wicri:level="1"><nlm:aff id="a86"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center</institution>, Los Angeles, California 90033,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Scott, Rodney" sort="Scott, Rodney" uniqKey="Scott R" first="Rodney" last="Scott">Rodney Scott</name><affiliation wicri:level="1"><nlm:aff id="a155"><institution>Division of Genetics, Hunter Area Pathology Service, John Hunter Hospital</institution>, Newcastle, New South Wales 2305,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Senter, Leigha" sort="Senter, Leigha" uniqKey="Senter L" first="Leigha" last="Senter">Leigha Senter</name><affiliation wicri:level="1"><nlm:aff id="a138"><institution>Divison of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University</institution>, Columbus, Ohio 43210,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sharma, Priyanka" sort="Sharma, Priyanka" uniqKey="Sharma P" first="Priyanka" last="Sharma">Priyanka Sharma</name><affiliation wicri:level="1"><nlm:aff id="a156"><institution>Department of Hematology and Oncology, University of Kansas Medical Center</institution>, Kansas City, Kansas 66205,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation wicri:level="1"><nlm:aff id="a157"><institution>Centre Hospitalier Universitaire de Québec Research Center, Laval University</institution>, Quebec City, Quebec,<country>Canada</country> G1V 4G2</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Singer, Christian F" sort="Singer, Christian F" uniqKey="Singer C" first="Christian F." last="Singer">Christian F. Singer</name><affiliation wicri:level="1"><nlm:aff id="a143"><institution>Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna</institution>, A 1090 Vienna,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name><affiliation wicri:level="1"><nlm:aff id="a46"><institution>INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon</institution>, 69373 Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a158"><institution>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon—Centre Léon Bérard</institution>, 69373 Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation wicri:level="1"><nlm:aff id="a157"><institution>Centre Hospitalier Universitaire de Québec Research Center, Laval University</institution>, Quebec City, Quebec,<country>Canada</country> G1V 4G2</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Southey, Melissa" sort="Southey, Melissa" uniqKey="Southey M" first="Melissa" last="Southey">Melissa Southey</name><affiliation wicri:level="1"><nlm:aff id="a159"><institution>Department of Pathology, The University of Melbourne</institution>, Melbourne, Victoria,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Steinemann, Doris" sort="Steinemann, Doris" uniqKey="Steinemann D" first="Doris" last="Steinemann">Doris Steinemann</name><affiliation wicri:level="1"><nlm:aff id="a160"><institution>Hannover Medical School</institution>, 30625 Hannover,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stenmark Askmalm, Marie" sort="Stenmark Askmalm, Marie" uniqKey="Stenmark Askmalm M" first="Marie" last="Stenmark-Askmalm">Marie Stenmark-Askmalm</name><affiliation wicri:level="1"><nlm:aff id="a161"><institution>Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University</institution>, SE-58185 Linköping,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation wicri:level="1"><nlm:aff id="a162"><institution>Institut Curie, Department of Tumour Biology</institution>, 75248 Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a163"><institution>Université Paris Descartes, Sorbonne Paris Cité</institution>, 75248 Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation wicri:level="1"><nlm:aff id="a104"><institution>Division of Genetics and Epidemiology, Institute of Cancer Research</institution>, Sutton SM2 5NG,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I." last="Szabo">Csilla I. Szabo</name><affiliation wicri:level="1"><nlm:aff id="a164"><institution>National Human Genome Research Institute, National Institutes of Health</institution>, Bethesda, Maryland 20892-2152,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tamimi, Rulla" sort="Tamimi, Rulla" uniqKey="Tamimi R" first="Rulla" last="Tamimi">Rulla Tamimi</name><affiliation wicri:level="1"><nlm:aff id="a61"><institution>Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a62"><institution>Department of Epidemiology, Harvard School of Public Health</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a119"><institution>Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tapper, William" sort="Tapper, William" uniqKey="Tapper W" first="William" last="Tapper">William Tapper</name><affiliation wicri:level="1"><nlm:aff id="a56"><institution>Faculty of Medicine, University of Southampton, University Hospital Southampton</institution>, Southampton, Hampshire SO16 6YD,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Teixeira, Manuel R" sort="Teixeira, Manuel R" uniqKey="Teixeira M" first="Manuel R." last="Teixeira">Manuel R. Teixeira</name><affiliation wicri:level="1"><nlm:aff id="a165"><institution>Department of Genetics, Portuguese Oncology Institute</institution>, Porto, 4200-072,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a166"><institution>Biomedical Sciences Institute (ICBAS), Porto University</institution>, 4200-072 Porto,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo-Hwang" last="Teo">Soo-Hwang Teo</name><affiliation wicri:level="1"><nlm:aff id="a167"><institution>Cancer Research Initiatives Foundation, Sime Darby Medical Centre</institution>, Subang Jaya 47500,<country>Malaysia</country></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a168"><institution>University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya</institution>, Kuala Lumpur 50603,<country>Malaysia</country></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Terry, Mary B" sort="Terry, Mary B" uniqKey="Terry M" first="Mary B." last="Terry">Mary B. Terry</name><affiliation wicri:level="1"><nlm:aff id="a169"><institution>Department of Epidemiology, Mailman School of Public Health, Columbia University</institution>, New York, New York, 10032,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name><affiliation wicri:level="1"><nlm:aff id="a170"><institution>Department of Clinical Genetics, Odense University Hospital</institution>, 5000 Odense C,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thompson, Deborah" sort="Thompson, Deborah" uniqKey="Thompson D" first="Deborah" last="Thompson">Deborah Thompson</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tihomirova, Laima" sort="Tihomirova, Laima" uniqKey="Tihomirova L" first="Laima" last="Tihomirova">Laima Tihomirova</name><affiliation wicri:level="1"><nlm:aff id="a171"><institution>Latvian Biomedical Research and Study Centre</institution>, LV-1067 Riga,<country>Latvia</country></nlm:aff><country xml:lang="fr">Lettonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name><affiliation wicri:level="1"><nlm:aff id="a172"><institution>Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University</institution>, Columbus, Ohio, 43210,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name><affiliation wicri:level="1"><nlm:aff id="a173"><institution>Department of Surgical Oncology, Leiden University Medical Center</institution>, Leiden 2333 ZC,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation wicri:level="1"><nlm:aff id="a174"><institution>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford</institution>, Oxford OX3 7BN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation wicri:level="1"><nlm:aff id="a84"><institution>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer</institution>, 70-115 Villejuif,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tsimiklis, Helen" sort="Tsimiklis, Helen" uniqKey="Tsimiklis H" first="Helen" last="Tsimiklis">Helen Tsimiklis</name><affiliation wicri:level="1"><nlm:aff id="a159"><institution>Department of Pathology, The University of Melbourne</institution>, Melbourne, Victoria,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Teule, Alex" sort="Teule, Alex" uniqKey="Teule A" first="Alex" last="Teulé">Alex Teulé</name><affiliation wicri:level="1"><nlm:aff id="a175"><institution>Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology</institution>, 08908 Barcelona,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tumino, Rosario" sort="Tumino, Rosario" uniqKey="Tumino R" first="Rosario" last="Tumino">Rosario Tumino</name><affiliation wicri:level="1"><nlm:aff id="a176"><institution>Cancer Registry and Histopathology Unit, ‘Civic—M.P. Arezzo' Hospital</institution>, 97100 ASP Ragusa,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tung, Nadine" sort="Tung, Nadine" uniqKey="Tung N" first="Nadine" last="Tung">Nadine Tung</name><affiliation wicri:level="1"><nlm:aff id="a177"><institution>Department of Medical Oncology, Beth Israel Deaconess Medical Center</institution>, Boston, Massachusetts, 02215,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name><affiliation wicri:level="1"><nlm:aff id="a141"><institution>Section of Cancer Genetics, Institute of Cancer Research</institution>, Sutton SM2 5NG,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ursin, Giski" sort="Ursin, Giski" uniqKey="Ursin G" first="Giski" last="Ursin">Giski Ursin</name><affiliation wicri:level="1"><nlm:aff id="a178"><institution>Cancer Registry of Norway, Institute of Population-Based Cancer Research</institution>, N-0304 Oslo,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Deurzen, Carolien H M" sort="Van Deurzen, Carolien H M" uniqKey="Van Deurzen C" first="Carolien H. M." last="Van Deurzen">Carolien H. M. Van Deurzen</name><affiliation wicri:level="1"><nlm:aff id="a179"><institution>Department of Pathology, Family Cancer Clinic, Erasmus University Medical Center</institution>, Rotterdam 3000 CA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Rensburg, Elizabeth J" sort="Van Rensburg, Elizabeth J" uniqKey="Van Rensburg E" first="Elizabeth J." last="Van Rensburg">Elizabeth J. Van Rensburg</name><affiliation wicri:level="1"><nlm:aff id="a52"><institution>Department of Genetics, University of Pretoria</institution>, Pretoria 0007,<country>South Africa</country></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Varon Mateeva, Raymonda" sort="Varon Mateeva, Raymonda" uniqKey="Varon Mateeva R" first="Raymonda" last="Varon-Mateeva">Raymonda Varon-Mateeva</name><affiliation wicri:level="1"><nlm:aff id="a180"><institution>Institute of Human Genetics, Charite Berlin</institution>, 13353 Berlin,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation wicri:level="1"><nlm:aff id="a181"><institution>Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>, Gaithersburg, Maryland 20877,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name><affiliation wicri:level="1"><nlm:aff id="a182"><institution>University Hospital Ulm</institution>, 89075 Ulm, ,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation wicri:level="1"><nlm:aff id="a44"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, SE-17177 Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a178"><institution>Cancer Registry of Norway, Institute of Population-Based Cancer Research</institution>, N-0304 Oslo,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a183"><institution>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø—The Arctic University of Norway</institution>, 9037 Tromsø,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a184"><institution>Genetic Epidemiology Group, Folkhälsan Research Center</institution>, 2016 Helsinki,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Weitzel, Jeffrey N" sort="Weitzel, Jeffrey N" uniqKey="Weitzel J" first="Jeffrey N." last="Weitzel">Jeffrey N. Weitzel</name><affiliation wicri:level="1"><nlm:aff id="a91"><institution>Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network</institution>, Duarte, California 91010,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Whittemore, Alice" sort="Whittemore, Alice" uniqKey="Whittemore A" first="Alice" last="Whittemore">Alice Whittemore</name><affiliation wicri:level="1"><nlm:aff id="a185"><institution>Department of Health Research and Policy—Epidemiology, Stanford University School of Medicine</institution>, Stanford, California 94305,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wildiers, Hans" sort="Wildiers, Hans" uniqKey="Wildiers H" first="Hans" last="Wildiers">Hans Wildiers</name><affiliation wicri:level="1"><nlm:aff id="a186"><institution>Multidisciplinary Breast Center, Department of General Medical Oncology, University Hospitals</institution>, B-3000 Leuven,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation wicri:level="1"><nlm:aff id="a139"><institution>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu/Oulu University Hospital</institution>, FI-90220 Oulu,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Xiaohong R" sort="Yang, Xiaohong R" uniqKey="Yang X" first="Xiaohong R." last="Yang">Xiaohong R. Yang</name><affiliation wicri:level="1"><nlm:aff id="a187"><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>, Bethesda, Maryland 20892,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name><affiliation wicri:level="1"><nlm:aff id="a66"><institution>Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research ‘Demokritos', Aghia Paraskevi Attikis</institution>, 15310 Athens,<country>Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yao, Song" sort="Yao, Song" uniqKey="Yao S" first="Song" last="Yao">Song Yao</name><affiliation wicri:level="1"><nlm:aff id="a11"><institution>Department of Cancer Prevention and Control, Roswell Park Cancer Institute</institution>, Buffalo, New York 14263,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M Pilar" last="Zamora">M Pilar Zamora</name><affiliation wicri:level="1"><nlm:aff id="a188"><institution>Servicio de Oncología Médica, Hospital Universitario La Paz</institution>, 28046 Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation wicri:level="1"><nlm:aff id="a121"><institution>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>, Nashville, Tennessee 37203,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation wicri:level="1"><nlm:aff id="a44"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, SE-17177 Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation wicri:level="1"><nlm:aff id="a62"><institution>Department of Epidemiology, Harvard School of Public Health</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a119"><institution>Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a189"><institution>Department of Biostatistics, Harvard School Of Public Health</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, Minnesota 55905,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Slager, Susan" sort="Slager, Susan" uniqKey="Slager S" first="Susan" last="Slager">Susan Slager</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, Minnesota 55905,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation wicri:level="1"><nlm:aff id="a190"><institution>Cancer Division, QIMR Berghofer Medical Research Institute</institution>, Brisbane, Queensland 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation wicri:level="1"><nlm:aff id="a55"><institution>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Monteiro, Alvaro A N" sort="Monteiro, Alvaro A N" uniqKey="Monteiro A" first="Alvaro A. N." last="Monteiro">Alvaro A. N. Monteiro</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute</institution>, Tampa, Florida 33612,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation wicri:level="1"><nlm:aff id="a191"><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</institution>, Rockville, Maryland 20850,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature Communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (<italic>P</italic><5 × 10<sup>−8</sup>) with oestrogen receptor (ER)-negative breast cancer and <italic>BRCA1</italic>-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative cases and 14,352 controls, combined with 7,333 ER-negative cases and 42,468 controls and 15,252 <italic>BRCA1</italic> mutation carriers genotyped on the iCOGS array. We identify four previously unidentified loci including two loci at 13q22 near <italic>KLF5</italic>, a 2p23.2 locus near <italic>WDR43</italic> and a 2q33 locus near <italic>PPIL3</italic> that display genome-wide significant associations with ER-negative breast cancer. In addition, 19 known breast cancer risk loci have genome-wide significant associations and 40 had moderate associations (<italic>P</italic><0.05) with ER-negative disease. Using functional and eQTL studies we implicate <italic>TRMT61B</italic> and <italic>WDR43</italic> at 2p23.2 and <italic>PPIL3</italic> at 2q33 in ER-negative breast cancer aetiology. All ER-negative loci combined account for ∼11% of familial relative risk for ER-negative disease and may contribute to improved ER-negative and <italic>BRCA1</italic> breast cancer risk prediction.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kamangar, F" uniqKey="Kamangar F">F. Kamangar</name></author><author><name sortKey="Dores, G M" uniqKey="Dores G">G. M. Dores</name></author><author><name sortKey="Anderson, W F" uniqKey="Anderson W">W. F. Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Slattery, M L" uniqKey="Slattery M">M. L. Slattery</name></author><author><name sortKey="Kerber, R A" uniqKey="Kerber R">R. A. Kerber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Michailidou, K" uniqKey="Michailidou K">K. Michailidou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Easton, D F" uniqKey="Easton D">D. F. Easton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hunter, D J" uniqKey="Hunter D">D. J. Hunter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stacey, S N" uniqKey="Stacey S">S. N. Stacey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stacey, S N" uniqKey="Stacey S">S. N. Stacey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ahmed, S" uniqKey="Ahmed S">S. Ahmed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, W" uniqKey="Zheng W">W. Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomas, G" uniqKey="Thomas G">G. Thomas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turnbull, C" uniqKey="Turnbull C">C. 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M.</given-names></name><xref ref-type="aff" rid="a179">179</xref></contrib><contrib contrib-type="author"><name><surname>van Rensburg</surname><given-names>Elizabeth J.</given-names></name><xref ref-type="aff" rid="a52">52</xref></contrib><contrib contrib-type="author"><name><surname>Varon-Mateeva</surname><given-names>Raymonda</given-names></name><xref ref-type="aff" rid="a180">180</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Zhaoming</given-names></name><xref ref-type="aff" rid="a181">181</xref></contrib><contrib contrib-type="author"><name><surname>Wang-Gohrke</surname><given-names>Shan</given-names></name><xref ref-type="aff" rid="a182">182</xref></contrib><contrib contrib-type="author"><name><surname>Weiderpass</surname><given-names>Elisabete</given-names></name><xref ref-type="aff" rid="a44">44</xref><xref ref-type="aff" rid="a178">178</xref><xref ref-type="aff" rid="a183">183</xref><xref ref-type="aff" rid="a184">184</xref></contrib><contrib contrib-type="author"><name><surname>Weitzel</surname><given-names>Jeffrey N.</given-names></name><xref ref-type="aff" rid="a91">91</xref></contrib><contrib contrib-type="author"><name><surname>Whittemore</surname><given-names>Alice</given-names></name><xref ref-type="aff" rid="a185">185</xref></contrib><contrib contrib-type="author"><name><surname>Wildiers</surname><given-names>Hans</given-names></name><xref ref-type="aff" rid="a186">186</xref></contrib><contrib contrib-type="author"><name><surname>Winqvist</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="a139">139</xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Xiaohong R.</given-names></name><xref ref-type="aff" rid="a187">187</xref></contrib><contrib contrib-type="author"><name><surname>Yannoukakos</surname><given-names>Drakoulis</given-names></name><xref ref-type="aff" rid="a66">66</xref></contrib><contrib contrib-type="author"><name><surname>Yao</surname><given-names>Song</given-names></name><xref ref-type="aff" rid="a11">11</xref></contrib><contrib contrib-type="author"><name><surname>Zamora</surname><given-names>M Pilar</given-names></name><xref ref-type="aff" rid="a188">188</xref></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Wei</given-names></name><xref ref-type="aff" rid="a121">121</xref></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>Per</given-names></name><xref ref-type="aff" rid="a44">44</xref></contrib><contrib contrib-type="author"><name><surname>Kraft</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="a62">62</xref><xref ref-type="aff" rid="a119">119</xref><xref ref-type="aff" rid="a189">189</xref></contrib><contrib contrib-type="author"><name><surname>Vachon</surname><given-names>Celine</given-names></name><xref ref-type="aff" rid="a2">2</xref></contrib><contrib contrib-type="author"><name><surname>Slager</surname><given-names>Susan</given-names></name><xref ref-type="aff" rid="a2">2</xref></contrib><contrib contrib-type="author"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><xref ref-type="aff" rid="a190">190</xref><xref ref-type="author-notes" rid="n2">†</xref></contrib><contrib contrib-type="author"><name><surname>Pharoah</surname><given-names>Paul D. P.</given-names></name><xref ref-type="aff" rid="a55">55</xref><xref ref-type="author-notes" rid="n2">†</xref></contrib><contrib contrib-type="author"><name><surname>Monteiro</surname><given-names>Alvaro A. N.</given-names></name><xref ref-type="aff" rid="a4">4</xref><xref ref-type="author-notes" rid="n2">†</xref></contrib><contrib contrib-type="author"><name><surname>García-Closas</surname><given-names>Montserrat</given-names></name><xref ref-type="aff" rid="a191">191</xref><xref ref-type="author-notes" rid="n2">†</xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F.</given-names></name><xref ref-type="aff" rid="a3">3</xref><xref ref-type="author-notes" rid="n2">†</xref></contrib><contrib contrib-type="author"><name><surname>Antoniou</surname><given-names>Antonis C.</given-names></name><xref ref-type="aff" rid="a3">3</xref><xref ref-type="author-notes" rid="n2">†</xref></contrib><aff id="a1"><label>1</label><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution>, Rochester, Minnesota 55905,<country>USA</country></aff><aff id="a2"><label>2</label><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, Minnesota 55905,<country>USA</country></aff><aff id="a3"><label>3</label><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></aff><aff id="a4"><label>4</label><institution>Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute</institution>, Tampa, Florida 33612,<country>USA</country></aff><aff id="a5"><label>5</label><institution>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet</institution>, N-0310 Oslo,<country>Norway</country></aff><aff id="a6"><label>6</label><institution>Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV—IRCCS</institution>, 20133 Padua,<country>Italy</country></aff><aff id="a7"><label>7</label><institution>Department of Health Studies, The University of Chicago</institution>, Chicago, Illinois 60637,<country>USA</country></aff><aff id="a8"><label>8</label><institution>Comprehensive Cancer Center, The University of Chicago</institution>, Chicago, Illinois 60637,<country>USA</country></aff><aff id="a9"><label>9</label><institution>Departments of Medicine and Human Genetics, The University of Chicago</institution>, Chicago, Illinois 60637,<country>USA</country></aff><aff id="a10"><label>10</label><institution>Department of Clinical Genetics, Helsinki University Central Hospital</institution>, 00029 Helsinki,<country>Finland</country></aff><aff id="a11"><label>11</label><institution>Department of Cancer Prevention and Control, Roswell Park Cancer Institute</institution>, Buffalo, New York 14263,<country>USA</country></aff><aff id="a12"><label>12</label><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>, Toronto, Ontario,<country>Canada</country> M5G 1X5</aff><aff id="a13"><label>13</label><institution>Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto</institution>, Ontario,<country>Canada</country> M5B 1W8</aff><aff id="a14"><label>14</label><institution>Department of Epidemiology, University of California Irvine</institution>, Irvine, California, 92697,<country>USA</country></aff><aff id="a15"><label>15</label><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>, 69120 Heidelberg,<country>Germany</country></aff><aff id="a16"><label>16</label><institution>University of Texas MD Anderson Cancer Center</institution>, Houston, Texas 77030,<country>USA</country></aff><aff id="a17"><label>17</label><institution>Department of Oncology, Karolinska University Hospital</institution>, SE-17176 Stockholm,<country>Sweden</country></aff><aff id="a18"><label>18</label><institution>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia</institution>, 20141 Milan,<country>Italy</country></aff><aff id="a19"><label>19</label><institution>Department of Pathology, Landspitali University Hospital and University of Iceland School of Medicine</institution>, 101 Reykjavik,<country>Iceland</country></aff><aff id="a20"><label>20</label><institution>Institute for Quality and Efficiency in Health Care (IQWiG)</institution>, 50670 Cologne,<country>Germany</country></aff><aff id="a21"><label>21</label><institution>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN</institution>, 91054 Erlangen,<country>Germany</country></aff><aff id="a22"><label>22</label><institution>Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO)</institution>, 28029 Madrid,<country>Spain</country></aff><aff id="a23"><label>23</label><institution>Genotyping Unit (CeGen), Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO)</institution>, 28029 Madrid,<country>Spain</country></aff><aff id="a24"><label>24</label><institution>Biomedical Network on Rare Diseases (CIBERER)</institution>, 28029 Madrid,<country>Spain</country></aff><aff id="a25"><label>25</label><institution>NYU Women's Cancer Program, New York University School of Medicine</institution>, New York, New York 10016,<country>USA</country></aff><aff id="a26"><label>26</label><institution>Department of Oncology, University of Helsinki and Helsinki University Central Hospital</institution>, FI-00029 Helsinki,<country>Finland</country></aff><aff id="a27"><label>27</label><institution>Department of Radiation Oncology, Hannover Medical School</institution>, 30625 Hannover,<country>Germany</country></aff><aff id="a28"><label>28</label><institution>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital</institution>, 2730 Herlev,<country>Denmark</country></aff><aff id="a29"><label>29</label><institution>Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology</institution>, 70376 Stuttgart,<country>Germany</country></aff><aff id="a30"><label>30</label><institution>University of Tübingen</institution> 72074 Tübingen,<country>Germany</country></aff><aff id="a31"><label>31</label><institution>Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT)</institution>, 69120 Heidelberg,<country>Germany</country></aff><aff id="a32"><label>32</label><institution>Department of Obstetrics and Gynecology, University of Heidelberg</institution>, 69120 Heidelberg,<country>Germany</country></aff><aff id="a33"><label>33</label><institution>Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine</institution>, Salt Lake City Utah 84112,<country>USA</country></aff><aff id="a34"><label>34</label><institution>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC</institution>, Madrid 28040,<country>Spain</country></aff><aff id="a35"><label>35</label><institution>Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa</institution>, I-56126 Pisa,<country>Italy</country></aff><aff id="a36"><label>36</label><institution>Genomic Epidemiology Group, German Cancer Research Center (DKFZ)</institution>, 69120 Heidelberg,<country>Germany</country></aff><aff id="a37"><label>37</label><institution>Australian Breast Cancer Tissue Bank, Westmead Millennium Institute, University of Sydney</institution>, Sydney, New South Wales 2145,<country>Australia</country></aff><aff id="a38"><label>38</label><institution>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)</institution>, 69120 Heidelberg,<country>Germany</country></aff><aff id="a39"><label>39</label><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>, Rockville, Maryland 20850,<country>USA</country></aff><aff id="a40"><label>40</label><institution>Departments of Pediatrics and Medicine, Columbia University</institution>, New York, New York 10032,<country>USA</country></aff><aff id="a41"><label>41</label><institution>Center for Medical Genetics, Ghent University</institution>, 9000 Ghent,<country>Belgium</country></aff><aff id="a42"><label>42</label><institution>Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield</institution>, Sheffield S10 2RX,<country>UK</country></aff><aff id="a43"><label>43</label><institution>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield</institution>, Sheffield S10 2HQ,<country>UK</country></aff><aff id="a44"><label>44</label><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, SE-17177 Stockholm,<country>Sweden</country></aff><aff id="a45"><label>45</label><institution>Department of Clinical Genetics, Fox Chase Cancer Center</institution>, Philadelphia, Pennsylvania 19111,<country>USA</country></aff><aff id="a46"><label>46</label><institution>INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon</institution>, 69373 Lyon,<country>France</country></aff><aff id="a47"><label>47</label><institution>Department of Human Genetics and Department of Pathology, Leiden University Medical Center</institution>, Leiden 2333 ZC,<country>The Netherlands</country></aff><aff id="a48"><label>48</label><institution>Oncogenetics Group, University Hospital Vall d'Hebron, Vall d'Hebron Institute of Oncology (VHIO) and Universitat Autònoma de Barcelona</institution>, 08035 Barcelona,<country>Spain</country></aff><aff id="a49"><label>49</label><institution>Department of Population Sciences, Beckman Research Institute of City of Hope</institution>, Duarte, California 91010,<country>USA</country></aff><aff id="a50"><label>50</label><institution>Cancer Bioimmunotherapy Unit, CRO Aviano National Cancer Institute</institution>, 33081 Aviano ,<country>Italy</country></aff><aff id="a51"><label>51</label><institution>Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania</institution>, Pennsylvania 19104,<country>USA</country></aff><aff id="a52"><label>52</label><institution>Department of Genetics, University of Pretoria</institution>, Pretoria 0007,<country>South Africa</country></aff><aff id="a53"><label>53</label><institution>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine</institution>, London, WC1E 7HT,<country>UK</country></aff><aff id="a54"><label>54</label><institution>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University</institution>, Quebec City, Quebec,<country>Canada</country> G1V 4G2</aff><aff id="a55"><label>55</label><institution>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge</institution>, Cambridge CB1 8RN,<country>UK</country></aff><aff id="a56"><label>56</label><institution>Faculty of Medicine, University of Southampton, University Hospital Southampton</institution>, Southampton, Hampshire SO16 6YD,<country>UK</country></aff><aff id="a57"><label>57</label><institution>Department of Immunology, Genetics and Pathology, Uppsala University</institution>, Uppsala SE-751 85,<country>Sweden</country></aff><aff id="a58"><label>58</label><institution>Department of Clinical Genetics, Lund University Hospital</institution>, SE-22185 Lund,<country>Sweden</country></aff><aff id="a59"><label>59</label><institution>Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg</institution>, 91054 Erlangen,<country>Germany</country></aff><aff id="a60"><label>60</label><institution>Comprehensive Cancer Center -EMN</institution>, 91054 Erlangen,<country>Germany</country></aff><aff id="a61"><label>61</label><institution>Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School</institution>, Boston, Massachusetts 02115,<country>USA</country></aff><aff id="a62"><label>62</label><institution>Department of Epidemiology, Harvard School of Public Health</institution>, Boston, Massachusetts 02115,<country>USA</country></aff><aff id="a63"><label>63</label><institution>Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf</institution>, 20246 Hamburg,<country>Germany</country></aff><aff id="a64"><label>64</label><institution>Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ)</institution>, 69120 Heidelberg,<country>Germany</country></aff><aff id="a65"><label>65</label><institution>Center for Primary Health Care Research, Lund University</institution>, SE-221 00 Malmö,<country>Sweden</country></aff><aff id="a66"><label>66</label><institution>Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research ‘Demokritos', Aghia Paraskevi Attikis</institution>, 15310 Athens,<country>Greece</country></aff><aff id="a67"><label>67</label><institution>Program in Cancer Genetics, McGill University</institution>, Montreal, Quebec,<country>Canada</country> H3A 0G4</aff><aff id="a68"><label>68</label><institution>University of</institution>, Philadelphia, Pennsylvania 19104,<country>USA</country></aff><aff id="a69"><label>69</label><institution>Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center</institution>, Tel-Hashomer 52621,<country>Israel</country></aff><aff id="a70"><label>70</label><institution>Department of Epidemiology, University of</institution>, Chapel Hill, North Carolina 27599-7400,<country>USA</country></aff><aff id="a71"><label>71</label><institution>UCLA Schools of Medicine and Public Health, Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center</institution>, Los Angeles, California 90095-6900,<country>USA</country></aff><aff id="a72"><label>72</label><institution>Epidemiology Research Program, American Cancer Society</institution>, Atlanta, Georgia 30303,<country>USA</country></aff><aff id="a73"><label>73</label><institution>Cancer Risk and Prevention Clinic, Dana Farber Cancer Institute</institution>, Boston, Massachusetts 02215,<country>USA</country></aff><aff id="a74"><label>74</label><institution>Department of Biomedical Sciences, Cedars Sinai Medical Center</institution>, Los Angeles, California 90048,<country>USA</country></aff><aff id="a75"><label>75</label><institution>Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital</institution>, DK-2100 Copenhagen,<country>Denmark</country></aff><aff id="a76"><label>76</label><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>, Melbourne, Victoria 3010,<country>Australia</country></aff><aff id="a77"><label>77</label><institution>Department of Pathology and Laboratory Medicine, University of Kansas Medical Center</institution>, Kansas City, Kansas, 66205,<country>USA</country></aff><aff id="a78"><label>78</label><institution>Department of Medicine, McGill University</institution>, Montreal, Quebec,<country>Canada</country> H3G 2M1</aff><aff id="a79"><label>79</label><institution>Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital</institution>, Montreal, Quebec,<country>Canada</country> H4A 3J1</aff><aff id="a80"><label>80</label><institution>Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine</institution>, Salt Lake City, Utah 84132,<country>USA</country></aff><aff id="a81"><label>81</label><institution>Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)</institution>, 28029 Madrid,<country>Spain</country></aff><aff id="a82"><label>82</label><institution>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</institution>, Rockville, Maryland 20850-9772,<country>USA</country></aff><aff id="a83"><label>83</label><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></aff><aff id="a84"><label>84</label><institution>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer</institution>, 70-115 Villejuif,<country>France</country></aff><aff id="a85"><label>85</label><institution>Department of of Epidemiology and Biostatistics, School of Public Health, Imperial College London</institution>, London, SW7 2AZ,<country>UK</country></aff><aff id="a86"><label>86</label><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center</institution>, Los Angeles, California 90033,<country>USA</country></aff><aff id="a87"><label>87</label><institution>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)</institution>, 69120 Heidelberg,<country>Germany</country></aff><aff id="a88"><label>88</label><institution>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital</institution>, DK-2100 Copenhagen,<country>Denmark</country></aff><aff id="a89"><label>89</label><institution>Department of Genetics, QIMR Berghofer Medical Research Institute</institution>, Brisbane, Queensland 4029,<country>Australia</country></aff><aff id="a90"><label>90</label><institution>Helsinki University Central Hospital</institution>, FI-00029 Helsinki,<country>Finland</country></aff><aff id="a91"><label>91</label><institution>Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network</institution>, Duarte, California 91010,<country>USA</country></aff><aff id="a92"><label>92</label><institution>Family Cancer Clinic, Netherlands Cancer Institute</institution>, Amsterdam 1000 BE,<country>The Netherlands</country></aff><aff id="a93"><label>93</label><institution>Department of Medical Oncology, Erasmus MC Cancer Institute</institution>, Rotterdam 3008 AE,<country>The Netherlands</country></aff><aff id="a94"><label>94</label><institution>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center</institution>, Rotterdam 3008 AE,<country>The Netherlands</country></aff><aff id="a95"><label>95</label><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne</institution>, Melbourne, Victoria 3010,<country>Australia</country></aff><aff id="a96"><label>96</label><institution>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health</institution>, Boston, Massachusetts 02115,<country>USA</country></aff><aff id="a97"><label>97</label><institution>N.N. Petrov Institute of Oncology</institution>, 197758 St Petersburg,<country>Russia</country></aff><aff id="a98"><label>98</label><institution>Lombardi Comprehensive Cancer Center, Georgetown University</institution>, Washington, DC 20007,<country>USA</country></aff><aff id="a99"><label>99</label><institution>Familial Cancer Centre, Peter MacCallum Cancer Centre</institution>, Melbourne, Victoria 8006,<country>Australia</country></aff><aff id="a100"><label>100</label><institution>Department of Oncology, The University of Melbourne</institution>, Melbourne, Victoria 8006,<country>Australia</country></aff><aff id="a101"><label>101</label><institution>State Research Institute Centre for Innovative Medicine</institution>, LT-08661 Vilnius,<country>Lithuania</country></aff><aff id="a102"><label>102</label><institution>Department of Clinical Genetics, Aarhus University Hospital</institution>, 8200 Aarhus N,<country>Denmark</country></aff><aff id="a103"><label>103</label><institution>Department of Epidemiology, Cancer Prevention Institute of California</institution>, Fremont, California 94538,<country>USA</country></aff><aff id="a104"><label>104</label><institution>Division of Genetics and Epidemiology, Institute of Cancer Research</institution>, Sutton SM2 5NG,<country>UK</country></aff><aff id="a105"><label>105</label><institution>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center</institution>, Los Angeles, California, 90048,<country>USA</country></aff><aff id="a106"><label>106</label><institution>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital</institution>, FI-00029 Helsinki,<country>Finland</country></aff><aff id="a107"><label>107</label><institution>Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory</institution>, Cambridge CB1 8RN,<country>UK</country></aff><aff id="a108"><label>108</label><institution>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>, Toronto, Ontario,<country>Canada</country> M5G 1X5</aff><aff id="a109"><label>109</label><institution>Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus</institution>, 53113 Bonn,<country>Germany</country></aff><aff id="a110"><label>110</label><institution>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland</institution>, FI-70211 Kuopio,<country>Finland</country></aff><aff id="a111"><label>111</label><institution>The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital</institution>, Hong Kong</aff><aff id="a112"><label>112</label><institution>Department of Surgery, The University of Hong Kong</institution>, Hong Kong,<country>China</country></aff><aff id="a113"><label>113</label><institution>Vesalius Research Center, VIB</institution>, 3000 Leuven,<country>Belgium</country></aff><aff id="a114"><label>114</label><institution>Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology</institution>, 08908 Barcelona,<country>Spain</country></aff><aff id="a115"><label>115</label><institution>Department of Preventive Medicine, University of Southern California</institution>, Los Angeles, California 90032,<country>USA</country></aff><aff id="a116"><label>116</label><institution>Cancer Epidemiology Program, University of Cancer Center</institution>, Honolulu, Hawaii 96813,<country>USA</country></aff><aff id="a117"><label>117</label><institution>Department of Molecular Medicine and Surgery, Karolinska Institutet</institution>, SE-17177 Stockholm,<country>Sweden</country></aff><aff id="a118"><label>118</label><institution>Health Sciences Research, Mayo Clinic</institution>, Scotsdale, Arizona 85259,<country>USA</country></aff><aff id="a119"><label>119</label><institution>Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health</institution>, Boston, Massachusetts 02115,<country>USA</country></aff><aff id="a120"><label>120</label><institution>Human Genetics Division, Genome Institute of Singapore</institution>, Singapore 138672,<country>Singapore</country></aff><aff id="a121"><label>121</label><institution>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>, Nashville, Tennessee 37203,<country>USA</country></aff><aff id="a122"><label>122</label><institution>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center</institution>, Seattle, Washington 98109,<country>USA</country></aff><aff id="a123"><label>123</label><institution>Department of Epidemiology, School of Public Health and Community Medicine, University of Washington</institution>, Seattle, Washington 98195,<country>USA</country></aff><aff id="a124"><label>124</label><institution>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT)</institution>, 20133 Milan,<country>Italy</country></aff><aff id="a125"><label>125</label><institution>Department of Gynaecology and Obstetrics, Technical University of Munich</institution>, 81675 Munich,<country>Germany</country></aff><aff id="a126"><label>126</label><institution>NRG Oncology Statistics and Data Management Center, Roswell Park Cancer Institute</institution>, Buffalo, New York 14263,<country>USA</country></aff><aff id="a127"><label>127</label><institution>Department of Genomics and Genome Sciences, Case Western Reserve University Medical School</institution>, Cleveland, Ohio 44106,<country>USA</country></aff><aff id="a128"><label>128</label><institution>Laboratory Medicine Program, University Health Network</institution>, Toronto, Ontario,<country>Canada</country> M5B 1W8</aff><aff id="a129"><label>129</label><institution>Department of Laboratory Medicine and Pathobiology, University of Toronto</institution>, Toronto, Ontario,<country>Canada</country> M5B 1W8</aff><aff id="a130"><label>130</label><institution>Invitae Corporation</institution>, San Francisco, California 94107,<country>USA</country></aff><aff id="a131"><label>131</label><institution>Department of Medicine, Memorial Sloan-Kettering Cancer Center</institution>, New York, New York 10065,<country>USA</country></aff><aff id="a132"><label>132</label><institution>Department of Molecular Genetics, National Institute of Oncology</institution>, H-1122 Budapest,<country>Hungary</country></aff><aff id="a133"><label>133</label><institution>Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center</institution>, Chicago, Illinois 60637,<country>USA</country></aff><aff id="a134"><label>134</label><institution>Department of Preventive Medicine and Biomedical Science, Seoul National University College of Medicine and Cancer Research Institute, Seoul National University</institution>, 110-799 Seoul,<country>Republic of Korea</country></aff><aff id="a135"><label>135</label><institution>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center</institution>, Utrecht 3508 GA,<country>The Netherlands</country></aff><aff id="a136"><label>136</label><institution>MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</institution>, London SW7 2AZ,<country>UK</country></aff><aff id="a137"><label>137</label><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>, 20133 Milan,<country>Italy</country></aff><aff id="a138"><label>138</label><institution>Divison of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University</institution>, Columbus, Ohio 43210,<country>USA</country></aff><aff id="a139"><label>139</label><institution>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu/Oulu University Hospital</institution>, FI-90220 Oulu,<country>Finland</country></aff><aff id="a140"><label>140</label><institution>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT)</institution>, 20133 Milan,<country>Italy</country></aff><aff id="a141"><label>141</label><institution>Section of Cancer Genetics, Institute of Cancer Research</institution>, Sutton SM2 5NG,<country>UK</country></aff><aff id="a142"><label>142</label><institution>Department of Clinical Genetics, Karolinska University Hospital</institution>, SE-17176 Stockholm,<country>Sweden</country></aff><aff id="a143"><label>143</label><institution>Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna</institution>, A 1090 Vienna,<country>Austria</country></aff><aff id="a144"><label>144</label><institution>Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine</institution>, Haifa 34362,<country>Israel</country></aff><aff id="a145"><label>145</label><institution>Department of Pathology, Johns Hopkins University School of Medicine</institution>, Baltimore, Maryland, 21205,<country>USA</country></aff><aff id="a146"><label>146</label><institution>International Agency for Research on Cancer</institution>, 69008 Lyon,<country>France</country></aff><aff id="a147"><label>147</label><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>, Amsterdam 1006 BE,<country>The Netherlands</country></aff><aff id="a148"><label>148</label><institution>Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada/Universidad de Granada</institution>, 18014 Granada,<country>Spain</country></aff><aff id="a149"><label>149</label><institution>CIBER de Epidemiología y Salud Pública (CIBERESP)</institution>,<country>Spain</country></aff><aff id="a150"><label>150</label><institution>Department of Environmental Health Sciences, Columbia University</institution>, New York, New York, 10032,<country>USA</country></aff><aff id="a151"><label>151</label><institution>Research Oncology, Division of Cancer Studies, King's College London, Guy's Hospital</institution>, London SE1 9RT,<country>UK</country></aff><aff id="a152"><label>152</label><institution>Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne</institution>, Cologne 50931,<country>Germany</country></aff><aff id="a153"><label>153</label><institution>Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne</institution>, 50931 Cologne,<country>Germany</country></aff><aff id="a154"><label>154</label><institution>Center for Molecular Medicine Cologne (CMMC), University of Cologne</institution>, 50931 Cologne,<country>Germany</country></aff><aff id="a155"><label>155</label><institution>Division of Genetics, Hunter Area Pathology Service, John Hunter Hospital</institution>, Newcastle, New South Wales 2305,<country>Australia</country></aff><aff id="a156"><label>156</label><institution>Department of Hematology and Oncology, University of Kansas Medical Center</institution>, Kansas City, Kansas 66205,<country>USA</country></aff><aff id="a157"><label>157</label><institution>Centre Hospitalier Universitaire de Québec Research Center, Laval University</institution>, Quebec City, Quebec,<country>Canada</country> G1V 4G2</aff><aff id="a158"><label>158</label><institution>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon—Centre Léon Bérard</institution>, 69373 Lyon,<country>France</country></aff><aff id="a159"><label>159</label><institution>Department of Pathology, The University of Melbourne</institution>, Melbourne, Victoria,<country>Australia</country></aff><aff id="a160"><label>160</label><institution>Hannover Medical School</institution>, 30625 Hannover,<country>Germany</country></aff><aff id="a161"><label>161</label><institution>Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University</institution>, SE-58185 Linköping,<country>Sweden</country></aff><aff id="a162"><label>162</label><institution>Institut Curie, Department of Tumour Biology</institution>, 75248 Paris,<country>France</country></aff><aff id="a163"><label>163</label><institution>Université Paris Descartes, Sorbonne Paris Cité</institution>, 75248 Paris,<country>France</country></aff><aff id="a164"><label>164</label><institution>National Human Genome Research Institute, National Institutes of Health</institution>, Bethesda, Maryland 20892-2152,<country>USA</country></aff><aff id="a165"><label>165</label><institution>Department of Genetics, Portuguese Oncology Institute</institution>, Porto, 4200-072,<country>Portugal</country></aff><aff id="a166"><label>166</label><institution>Biomedical Sciences Institute (ICBAS), Porto University</institution>, 4200-072 Porto,<country>Portugal</country></aff><aff id="a167"><label>167</label><institution>Cancer Research Initiatives Foundation, Sime Darby Medical Centre</institution>, Subang Jaya 47500,<country>Malaysia</country></aff><aff id="a168"><label>168</label><institution>University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya</institution>, Kuala Lumpur 50603,<country>Malaysia</country></aff><aff id="a169"><label>169</label><institution>Department of Epidemiology, Mailman School of Public Health, Columbia University</institution>, New York, New York, 10032,<country>USA</country></aff><aff id="a170"><label>170</label><institution>Department of Clinical Genetics, Odense University Hospital</institution>, 5000 Odense C,<country>Denmark</country></aff><aff id="a171"><label>171</label><institution>Latvian Biomedical Research and Study Centre</institution>, LV-1067 Riga,<country>Latvia</country></aff><aff id="a172"><label>172</label><institution>Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University</institution>, Columbus, Ohio, 43210,<country>USA</country></aff><aff id="a173"><label>173</label><institution>Department of Surgical Oncology, Leiden University Medical Center</institution>, Leiden 2333 ZC,<country>The Netherlands</country></aff><aff id="a174"><label>174</label><institution>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford</institution>, Oxford OX3 7BN,<country>UK</country></aff><aff id="a175"><label>175</label><institution>Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology</institution>, 08908 Barcelona,<country>Spain</country></aff><aff id="a176"><label>176</label><institution>Cancer Registry and Histopathology Unit, ‘Civic—M.P. Arezzo' Hospital</institution>, 97100 ASP Ragusa,<country>Italy</country></aff><aff id="a177"><label>177</label><institution>Department of Medical Oncology, Beth Israel Deaconess Medical Center</institution>, Boston, Massachusetts, 02215,<country>USA</country></aff><aff id="a178"><label>178</label><institution>Cancer Registry of Norway, Institute of Population-Based Cancer Research</institution>, N-0304 Oslo,<country>Norway</country></aff><aff id="a179"><label>179</label><institution>Department of Pathology, Family Cancer Clinic, Erasmus University Medical Center</institution>, Rotterdam 3000 CA,<country>The Netherlands</country></aff><aff id="a180"><label>180</label><institution>Institute of Human Genetics, Charite Berlin</institution>, 13353 Berlin,<country>Germany</country></aff><aff id="a181"><label>181</label><institution>Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>, Gaithersburg, Maryland 20877,<country>USA</country></aff><aff id="a182"><label>182</label><institution>University Hospital Ulm</institution>, 89075 Ulm, ,<country>Germany</country></aff><aff id="a183"><label>183</label><institution>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø—The Arctic University of Norway</institution>, 9037 Tromsø,<country>Norway</country></aff><aff id="a184"><label>184</label><institution>Genetic Epidemiology Group, Folkhälsan Research Center</institution>, 2016 Helsinki,<country>Finland</country></aff><aff id="a185"><label>185</label><institution>Department of Health Research and Policy—Epidemiology, Stanford University School of Medicine</institution>, Stanford, California 94305,<country>USA</country></aff><aff id="a186"><label>186</label><institution>Multidisciplinary Breast Center, Department of General Medical Oncology, University Hospitals</institution>, B-3000 Leuven,<country>Belgium</country></aff><aff id="a187"><label>187</label><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>, Bethesda, Maryland 20892,<country>USA</country></aff><aff id="a188"><label>188</label><institution>Servicio de Oncología Médica, Hospital Universitario La Paz</institution>, 28046 Madrid,<country>Spain</country></aff><aff id="a189"><label>189</label><institution>Department of Biostatistics, Harvard School Of Public Health</institution>, Boston, Massachusetts 02115,<country>USA</country></aff><aff id="a190"><label>190</label><institution>Cancer Division, QIMR Berghofer Medical Research Institute</institution>, Brisbane, Queensland 4029,<country>Australia</country></aff><aff id="a191"><label>191</label><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</institution>, Rockville, Maryland 20850,<country>USA</country></aff></contrib-group><author-notes><corresp id="c1"><label>a</label><email>couch.fergus@mayo.edu</email></corresp><fn id="n1"><label>*</label><p>These authors contributed equally to this work</p></fn><fn id="n2"><label>†</label><p>These authors jointly supervised this work.</p></fn></author-notes><pub-date pub-type="epub"><day>27</day><month>04</month><year>2016</year></pub-date><pub-date pub-type="collection"><year>2016</year></pub-date><volume>7</volume><elocation-id>11375</elocation-id><history><date date-type="received"><day>16</day><month>04</month><year>2015</year></date><date date-type="accepted"><day>21</day><month>03</month><year>2016</year></date></history><permissions><copyright-statement>Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.</copyright-statement><copyright-year>2016</copyright-year><copyright-holder>Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><pmc-comment>author-paid</pmc-comment>
<license-p>This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link></license-p></license></permissions><abstract><p>Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (<italic>P</italic><5 × 10<sup>−8</sup>) with oestrogen receptor (ER)-negative breast cancer and <italic>BRCA1</italic>-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative cases and 14,352 controls, combined with 7,333 ER-negative cases and 42,468 controls and 15,252 <italic>BRCA1</italic> mutation carriers genotyped on the iCOGS array. We identify four previously unidentified loci including two loci at 13q22 near <italic>KLF5</italic>, a 2p23.2 locus near <italic>WDR43</italic> and a 2q33 locus near <italic>PPIL3</italic> that display genome-wide significant associations with ER-negative breast cancer. In addition, 19 known breast cancer risk loci have genome-wide significant associations and 40 had moderate associations (<italic>P</italic><0.05) with ER-negative disease. Using functional and eQTL studies we implicate <italic>TRMT61B</italic> and <italic>WDR43</italic> at 2p23.2 and <italic>PPIL3</italic> at 2q33 in ER-negative breast cancer aetiology. All ER-negative loci combined account for ∼11% of familial relative risk for ER-negative disease and may contribute to improved ER-negative and <italic>BRCA1</italic> breast cancer risk prediction.</p></abstract><abstract abstract-type="web-summary"><p><inline-graphic id="i1" xlink:href="ncomms11375-i1.jpg"></inline-graphic>Oestrogen negative breast cancer is associated with a poor prognosis. In this study, the authors perform a meta-analysis of 11 breast cancer genome-wide association studies and identify four new loci associated with oestrogen negative breast cancer risk. These findings may aid in stratifying patients in the clinic.</p></abstract></article-meta></front><floats-group><fig id="f1"><label>Figure 1</label><caption><title>Manhattan plot of ER-negative breast cancer meta-analysis.</title><p>The Manhattan plot displays the strength of genetic association (−log<sub>10</sub><italic>P</italic>) versus chromosomal position (Mb), where each dot presents a genotyped or imputed (black circle) SNP. The black horizontal line represents the threshold for genome-wide significance (<italic>P</italic>=5 × 10<sup>−8</sup>).</p></caption><graphic xlink:href="ncomms11375-f1"></graphic></fig><fig id="f2"><label>Figure 2</label><caption><title>Novel ER-negative breast cancer loci.</title><p>The chromosomal position and strength of genetic association (−log<sub>10</sub><italic>P</italic>) is shown for all SNPs (<italic>P</italic><1 × 10<sup>−6</sup>) in BCAC/iCOGS data in the four novel risk loci. (<bold>a</bold>). 2p23 locus. The most significant SNP (rs67073037) is shown as a diamond. (<bold>b</bold>). 13q22 loci. The most significant SNP (rs6562760) is shown as a diamond. The second locus is shown in black. (<bold>c</bold>). 2q33 locus. The most significant SNPs (rs188686860; rs115635831) are shown as diamonds.</p></caption><graphic xlink:href="ncomms11375-f2"></graphic></fig><fig id="f3"><label>Figure 3</label><caption><title>The chromatin landscape of locus 2p23.2.</title><p>(<bold>a</bold>) The SNP rs4407214 is included in a genomic tile overlapping chromatin features indicative of promoters and enhancers, shaded red. (<bold>b</bold>,<bold>c</bold>). Luciferase assays showing activity in the tile containing SNP rs4407214 (highlighted in pink in <bold>a</bold>.) in MCF10A and CAL51, red box plots indicate significantly different from the control tile (<italic>P</italic><0.0001). Brown box plot indicates significant difference from the reference allele (<italic>P</italic>= 0.0059). (<bold>d</bold>) Electrophoretic mobility shift assay (EMSA) showing the formation of allele-specific complexes for rs4407214. M, major allele; m, minor allele. Lines 1, 2, 7, 8—no nuclear extract. Lines 3, 4, 5, 6—10 μg of MCF10A nuclear extract. Lines 9, 10, 11, 12—10 μg of CAL51 nuclear extract. Shift detected by comparison to bands (arrows #1 and #2).</p></caption><graphic xlink:href="ncomms11375-f3"></graphic></fig><table-wrap position="float" id="t1"><label>Table 1</label><caption><title>Common genetic variants from known breast cancer susceptibility loci displaying most significant genome-wide associations with ER-negative breast cancer risk.</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="char" char="."></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="char" char="."></col><col align="char" char="("></col><col align="left"></col><col align="char" char="."></col><col align="char" char="("></col><col align="center"></col><col align="left"></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50"><bold>Location</bold></th><th align="center" valign="top" char="." charoff="50"><bold>Position</bold></th><th align="center" valign="top" charoff="50"><bold>Nearest gene</bold></th><th align="center" valign="top" charoff="50"><bold>SNP</bold></th><th align="center" valign="top" charoff="50"><bold>Alleles</bold></th><th colspan="3" align="center" valign="top" char="." charoff="50"><bold>iCOGS/GWAS ER-negative</bold><hr></hr></th><th colspan="3" align="center" valign="top" char="." charoff="50"><bold>BRCA1 carriers</bold><hr></hr></th><th align="center" valign="top" charoff="50"><bold>Meta-analysis</bold></th></tr><tr><th align="left" valign="top" charoff="50"> </th><th align="char" valign="top" char="." charoff="50"> </th><th align="center" valign="top" charoff="50"> </th><th align="center" valign="top" charoff="50"> </th><th align="center" valign="top" charoff="50"> </th><th align="center" valign="top" char="." charoff="50"><bold>EAF</bold></th><th align="center" valign="top" char="(" charoff="50"><bold>OR (95% CI)</bold></th><th align="center" valign="top" charoff="50"><italic><bold>P</bold></italic></th><th align="center" valign="top" char="." charoff="50"><bold>EAF</bold></th><th align="center" valign="top" char="(" charoff="50"><bold>HR (95% CI)</bold></th><th align="center" valign="top" charoff="50"><italic><bold>P</bold></italic></th><th align="center" valign="top" charoff="50"><italic><bold>P</bold></italic><xref ref-type="fn" rid="t1-fn2">*</xref></th></tr></thead><tbody valign="top"><tr><td colspan="12" align="center" valign="top" charoff="50">Variants in known loci most significantly associated with overall breast cancer</td></tr><tr><td align="left" valign="top" charoff="50"><xref ref-type="fn" rid="t1-fn3">†</xref>1p36.2</td><td align="char" valign="top" char="." charoff="50">10563609</td><td align="center" valign="top" charoff="50"><italic>PEX14</italic></td><td align="center" valign="top" charoff="50">rs10864459</td><td align="center" valign="top" charoff="50">G/A</td><td align="char" valign="top" char="." charoff="50">0.32</td><td align="char" valign="top" char="(" charoff="50">0.90 (0.87–0.93)</td><td align="left" valign="top" charoff="50">2.13 × 10<sup>−9</sup></td><td align="char" valign="top" char="." charoff="50">0.31</td><td align="char" valign="top" char="(" charoff="50">0.95 (0.91–0.99)</td><td align="center" valign="top" charoff="50">0.01</td><td align="left" valign="top" charoff="50">4.60 × 10<sup>−10</sup></td></tr><tr><td align="left" valign="top" charoff="50"><xref ref-type="fn" rid="t1-fn3">†</xref>1q32.1</td><td align="char" valign="top" char="." charoff="50">202179042</td><td align="center" valign="top" charoff="50"><italic>LGR6</italic></td><td align="center" valign="top" charoff="50">rs17489300</td><td align="center" valign="top" charoff="50">A/C</td><td align="char" valign="top" char="." charoff="50">0.4</td><td align="char" valign="top" char="(" charoff="50">0.90 (0.87–0.93)</td><td align="left" valign="top" charoff="50">9.37 × 10<sup>−10</sup></td><td align="char" valign="top" char="." charoff="50">0.39</td><td align="char" valign="top" char="(" charoff="50">0.97 (0.93–1.01)</td><td align="center" valign="top" charoff="50">0.19</td><td align="left" valign="top" charoff="50">1.98 × 10<sup>−8</sup></td></tr><tr><td align="left" valign="top" charoff="50">1q32.1</td><td align="char" valign="top" char="." charoff="50">204518842</td><td align="center" valign="top" charoff="50"><italic>MDM4</italic></td><td align="center" valign="top" charoff="50">rs4245739</td><td align="center" valign="top" charoff="50">A/C</td><td align="char" valign="top" char="." charoff="50">0.26</td><td align="char" valign="top" char="(" charoff="50">1.13 (1.11–1.19)</td><td align="left" valign="top" charoff="50">5.53 × 10<sup>−15</sup></td><td align="char" valign="top" char="." charoff="50">0.28</td><td align="char" valign="top" char="(" charoff="50">1.09 (1.05–1.14)</td><td align="center" valign="top" charoff="50">6.83 × 10<sup>−5</sup></td><td align="left" valign="top" charoff="50">7.71 × 10<sup>−18</sup></td></tr><tr><td align="left" valign="top" charoff="50">2p24.1</td><td align="char" valign="top" char="." charoff="50">19184284</td><td align="center" valign="top" charoff="50"><italic>2p24.1</italic></td><td align="center" valign="top" charoff="50">rs12710696</td><td align="center" valign="top" charoff="50">C/T</td><td align="char" valign="top" char="." charoff="50">0.36</td><td align="char" valign="top" char="(" charoff="50">1.10 (1.06–1.13)</td><td align="left" valign="top" charoff="50">1.70 × 10<sup>−8</sup></td><td align="char" valign="top" char="." charoff="50">0.39</td><td align="char" valign="top" char="(" charoff="50">1.01 (0.97–1.05)</td><td align="center" valign="top" charoff="50">0.56</td><td align="left" valign="top" charoff="50">1.90 × 10<sup>−6</sup></td></tr><tr><td align="left" valign="top" charoff="50"><xref ref-type="fn" rid="t1-fn3">†</xref>2q14.2</td><td align="char" valign="top" char="." charoff="50">121088182</td><td align="center" valign="top" charoff="50"><italic>INHBB</italic></td><td align="center" valign="top" charoff="50">rs11903787</td><td align="center" valign="top" charoff="50">G/A</td><td align="char" valign="top" char="." charoff="50">0.25</td><td align="char" valign="top" char="(" charoff="50">0.90 (0.86–0.94)</td><td align="left" valign="top" charoff="50">8.57 × 10<sup>−7</sup></td><td align="char" valign="top" char="." charoff="50">0.26</td><td align="char" valign="top" char="(" charoff="50">0.91 (0.87–0.96)</td><td align="center" valign="top" charoff="50">2.0 × 10<sup>−4</sup></td><td align="left" valign="top" charoff="50">7.24 × 10<sup>−10</sup></td></tr><tr><td align="left" valign="top" charoff="50"><xref ref-type="fn" rid="t1-fn3">†</xref>5p15.3</td><td align="char" valign="top" char="." charoff="50">1280028</td><td align="center" valign="top" charoff="50"><italic>TERT</italic></td><td align="center" valign="top" charoff="50">rs2242652</td><td align="center" valign="top" charoff="50">A/G</td><td align="char" valign="top" char="." charoff="50">0.20</td><td align="char" valign="top" char="(" charoff="50">1.18 (1.13–1.23)</td><td align="left" valign="top" charoff="50">2.73 × 10<sup>−14</sup></td><td align="char" valign="top" char="." charoff="50">0.22</td><td align="char" valign="top" char="(" charoff="50">1.22 (1.16–1.28)</td><td align="center" valign="top" charoff="50">2.53 × 10<sup>−15</sup></td><td align="left" valign="top" charoff="50">7.58 × 10<sup>−28</sup></td></tr><tr><td align="left" valign="top" charoff="50">5p15.3</td><td align="char" valign="top" char="." charoff="50">1282319</td><td align="center" valign="top" charoff="50"><italic>TERT</italic></td><td align="center" valign="top" charoff="50">rs7726159</td><td align="center" valign="top" charoff="50">A/C</td><td align="char" valign="top" char="." charoff="50">0.34</td><td align="char" valign="top" char="(" charoff="50">1.09 (1.05–1.13)</td><td align="left" valign="top" charoff="50">2.19 × 10<sup>−6</sup></td><td align="char" valign="top" char="." charoff="50">0.35</td><td align="char" valign="top" char="(" charoff="50">1.07 (1.02–1.11)</td><td align="center" valign="top" charoff="50">1.79 × 10<sup>−3</sup></td><td align="left" valign="top" charoff="50">3.31 × 10<sup>−8</sup></td></tr><tr><td align="left" valign="top" charoff="50">5p15.3</td><td align="char" valign="top" char="." charoff="50">1297488</td><td align="center" valign="top" charoff="50"><italic>TERT</italic></td><td align="center" valign="top" charoff="50">rs2736108</td><td align="center" valign="top" charoff="50">T/C</td><td align="char" valign="top" char="." charoff="50">0.29</td><td align="char" valign="top" char="(" charoff="50">0.89 (0.86–0.93)</td><td align="left" valign="top" charoff="50">1.41 × 10<sup>−8</sup></td><td align="char" valign="top" char="." charoff="50">0.29</td><td align="char" valign="top" char="(" charoff="50">0.89 (0.86–0.93)</td><td align="center" valign="top" charoff="50">4.05 × 10<sup>−7</sup></td><td align="left" valign="top" charoff="50">3.05 × 10<sup>−14</sup></td></tr><tr><td align="left" valign="top" charoff="50">6q25.1</td><td align="char" valign="top" char="." charoff="50">151918856</td><td align="center" valign="top" charoff="50"><italic>ESR1</italic></td><td align="center" valign="top" charoff="50">rs12662670</td><td align="center" valign="top" charoff="50">T/G</td><td align="char" valign="top" char="." charoff="50">0.08</td><td align="char" valign="top" char="(" charoff="50">1.20 (1.18–1.32)</td><td align="left" valign="top" charoff="50">8.90 × 10<sup>−15</sup></td><td align="char" valign="top" char="." charoff="50">0.09</td><td align="char" valign="top" char="(" charoff="50">1.19 (1.11–1.27)</td><td align="center" valign="top" charoff="50">9.67 × 10<sup>−7</sup></td><td align="left" valign="top" charoff="50">1.32 × 10<sup>−19</sup></td></tr><tr><td align="left" valign="top" charoff="50"><xref ref-type="fn" rid="t1-fn3">†</xref>6q25.1</td><td align="char" valign="top" char="." charoff="50">151946152</td><td align="center" valign="top" charoff="50"><italic>ESR1</italic></td><td align="center" valign="top" charoff="50">rs11155804</td><td align="center" valign="top" charoff="50">A/T</td><td align="char" valign="top" char="." charoff="50">0.34</td><td align="char" valign="top" char="(" charoff="50">1.16 (1.12–1.19)</td><td align="left" valign="top" charoff="50">8.18 × 10<sup>−18</sup></td><td align="char" valign="top" char="." charoff="50">0.36</td><td align="char" valign="top" char="(" charoff="50">1.15 (1.11–1.20)</td><td align="center" valign="top" charoff="50">0.02</td><td align="left" valign="top" charoff="50">3.75 × 10<sup>−28</sup></td></tr><tr><td align="left" valign="top" charoff="50">10q21.2</td><td align="char" valign="top" char="." charoff="50">64278682</td><td align="center" valign="top" charoff="50"><italic>ZNF365</italic></td><td align="center" valign="top" charoff="50">rs10995190</td><td align="center" valign="top" charoff="50">G/A</td><td align="char" valign="top" char="." charoff="50">0.16</td><td align="char" valign="top" char="(" charoff="50">0.89 (0.85–0.93)</td><td align="left" valign="top" charoff="50">3.75 × 10<sup>−8</sup></td><td align="char" valign="top" char="." charoff="50">0.16</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.94–1.04)</td><td align="center" valign="top" charoff="50">0.66</td><td align="left" valign="top" charoff="50">8.23 × 10<sup>−6</sup></td></tr><tr><td align="left" valign="top" charoff="50"><xref ref-type="fn" rid="t1-fn3">†</xref>10q25.2</td><td align="char" valign="top" char="." charoff="50">114782803</td><td align="center" valign="top" charoff="50"><italic>TCF7L2</italic></td><td align="center" valign="top" charoff="50">rs6585202</td><td align="center" valign="top" charoff="50">T/C</td><td align="char" valign="top" char="." charoff="50">0.46</td><td align="char" valign="top" char="(" charoff="50">1.06 (1.04–1.10)</td><td align="left" valign="top" charoff="50">3.35 × 10<sup>−5</sup></td><td align="char" valign="top" char="." charoff="50">0.47</td><td align="char" valign="top" char="(" charoff="50">1.10 (1.05–1.14)</td><td align="center" valign="top" charoff="50">6.08 × 10<sup>−6</sup></td><td align="left" valign="top" charoff="50">1.32 × 10<sup>−9</sup></td></tr><tr><td align="left" valign="top" charoff="50"><xref ref-type="fn" rid="t1-fn3">†</xref>11p15.5</td><td align="char" valign="top" char="." charoff="50">1902097</td><td align="center" valign="top" charoff="50"><italic>LSP1</italic></td><td align="center" valign="top" charoff="50">rs4980383</td><td align="center" valign="top" charoff="50">C/T</td><td align="char" valign="top" char="." charoff="50">0.44</td><td align="char" valign="top" char="(" charoff="50">1.08 (1.05–1.12)</td><td align="left" valign="top" charoff="50">3.02 × 10<sup>−6</sup></td><td align="char" valign="top" char="." charoff="50">0.45</td><td align="char" valign="top" char="(" charoff="50">1.07 (1.03–1.11)</td><td align="center" valign="top" charoff="50">7.73 × 10<sup>−4</sup></td><td align="left" valign="top" charoff="50">9.41 × 10<sup>−9</sup></td></tr><tr><td align="left" valign="top" charoff="50"><xref ref-type="fn" rid="t1-fn3">†</xref>12p11.2</td><td align="char" valign="top" char="." charoff="50">28174817</td><td align="center" valign="top" charoff="50"><italic>PTHLH</italic></td><td align="center" valign="top" charoff="50">rs7297051</td><td align="center" valign="top" charoff="50">C/T</td><td align="char" valign="top" char="." charoff="50">0.24</td><td align="char" valign="top" char="(" charoff="50">0.86 (0.83–0.89)</td><td align="left" valign="top" charoff="50">1.48 × 10<sup>−14</sup></td><td align="char" valign="top" char="." charoff="50">0.23</td><td align="char" valign="top" char="(" charoff="50">0.89 (0.85–0.93)</td><td align="center" valign="top" charoff="50">2.89 × 10<sup>−7</sup></td><td align="left" valign="top" charoff="50">3.12 × 10<sup>−20</sup></td></tr><tr><td align="left" valign="top" charoff="50">12p11.2</td><td align="char" valign="top" char="." charoff="50">28155080</td><td align="center" valign="top" charoff="50"><italic>PTHLH</italic></td><td align="center" valign="top" charoff="50">rs10771399</td><td align="center" valign="top" charoff="50">A/G</td><td align="char" valign="top" char="." charoff="50">0.12</td><td align="char" valign="top" char="(" charoff="50">0.79 (0.78–0.87)</td><td align="left" valign="top" charoff="50">3.82 × 10<sup>−13</sup></td><td align="char" valign="top" char="." charoff="50">0.10</td><td align="char" valign="top" char="(" charoff="50">0.86 (0.80–0.91)</td><td align="center" valign="top" charoff="50">2.55 × 10<sup>−6</sup></td><td align="left" valign="top" charoff="50">7.18 × 10<sup>−18</sup></td></tr><tr><td align="left" valign="top" charoff="50"><xref ref-type="fn" rid="t1-fn3">†</xref>16q12.1</td><td align="char" valign="top" char="." charoff="50">52599188</td><td align="center" valign="top" charoff="50"><italic>TO</italic> × <italic>3</italic></td><td align="center" valign="top" charoff="50">rs4784227</td><td align="center" valign="top" charoff="50">C/T</td><td align="char" valign="top" char="." charoff="50">0.24</td><td align="char" valign="top" char="(" charoff="50">1.15 (1.11–1.19)</td><td align="left" valign="top" charoff="50">1.11 × 10<sup>−14</sup></td><td align="char" valign="top" char="." charoff="50">0.26</td><td align="char" valign="top" char="(" charoff="50">1.07 (1.02–1.12)</td><td align="center" valign="top" charoff="50">4.97 × 10<sup>−3</sup></td><td align="left" valign="top" charoff="50">6.44 × 10<sup>−15</sup></td></tr><tr><td align="left" valign="top" charoff="50">16q12.2</td><td align="char" valign="top" char="." charoff="50">53813367</td><td align="center" valign="top" charoff="50"><italic>FTO</italic></td><td align="center" valign="top" charoff="50">rs17817449</td><td align="center" valign="top" charoff="50">T/G</td><td align="char" valign="top" char="." charoff="50">0.41</td><td align="char" valign="top" char="(" charoff="50">0.91 (0.89–0.95)</td><td align="left" valign="top" charoff="50">2.83 × 10<sup>−7</sup></td><td align="char" valign="top" char="." charoff="50">0.41</td><td align="char" valign="top" char="(" charoff="50">0.95 (0.92–0.99)</td><td align="center" valign="top" charoff="50">0.02</td><td align="left" valign="top" charoff="50">5.26 × 10<sup>−8</sup></td></tr><tr><td align="left" valign="top" charoff="50">16q12.2</td><td align="char" valign="top" char="." charoff="50">53855291</td><td align="center" valign="top" charoff="50"><italic>FTO</italic></td><td align="center" valign="top" charoff="50">rs11075995</td><td align="center" valign="top" charoff="50">T/A</td><td align="char" valign="top" char="." charoff="50">0.24</td><td align="char" valign="top" char="(" charoff="50">1.11 (1.07–1.15)</td><td align="left" valign="top" charoff="50">3.30 × 10<sup>−8</sup></td><td align="char" valign="top" char="." charoff="50">0.24</td><td align="char" valign="top" char="(" charoff="50">1.01 (0.97–1.06)</td><td align="center" valign="top" charoff="50">0.61</td><td align="left" valign="top" charoff="50">1.56 × 10<sup>−6</sup></td></tr><tr><td align="left" valign="top" charoff="50">19p13.1</td><td align="char" valign="top" char="." charoff="50">17389704</td><td align="center" valign="top" charoff="50"><italic>MERIT40</italic></td><td align="center" valign="top" charoff="50">rs8170</td><td align="center" valign="top" charoff="50">G/A</td><td align="char" valign="top" char="." charoff="50">0.19</td><td align="char" valign="top" char="(" charoff="50">1.15 (1.11–1.20)</td><td align="left" valign="top" charoff="50">1.35 × 10<sup>−12</sup></td><td align="char" valign="top" char="." charoff="50">0.19</td><td align="char" valign="top" char="(" charoff="50">1.17 (1.11–1.23)</td><td align="center" valign="top" charoff="50">7.29 × 10<sup>−10</sup></td><td align="left" valign="top" charoff="50">6.64 × 10<sup>−21</sup></td></tr><tr><td align="left" valign="top" charoff="50"><xref ref-type="fn" rid="t1-fn3">†</xref>19p13.1</td><td align="char" valign="top" char="." charoff="50">17393925</td><td align="center" valign="top" charoff="50"><italic>ADHB8</italic></td><td align="center" valign="top" charoff="50">rs56069439</td><td align="center" valign="top" charoff="50">C/A</td><td align="char" valign="top" char="." charoff="50">0.30</td><td align="char" valign="top" char="(" charoff="50">1.16 (1.13–1.20)</td><td align="left" valign="top" charoff="50">8.25 × 10<sup>−19</sup></td><td align="char" valign="top" char="." charoff="50">0.30</td><td align="char" valign="top" char="(" charoff="50">1.19 (1.14–1.24)</td><td align="center" valign="top" charoff="50">1.42 × 10<sup>−15</sup></td><td align="left" valign="top" charoff="50">1.49 × 10<sup>−32</sup></td></tr></tbody></table><table-wrap-foot><fn id="t1-fn1"><p>CI, confidence interval; EAF, effect allele frequency; ER, oestrogen receptor; GWAS, genome-wide association studies; HR, hazard ratio; OR, odds ratio; SNP, single-nucleotide polymorphism.</p></fn><fn id="t1-fn2"><p><sup>*</sup><italic>P</italic> values from iCOGS/BCAC and meta-analysis for ER-negative breast cancer were estimated by <italic>z</italic>-test. <italic>P</italic> values for <italic>BRCA1</italic> carriers were estimated by a kinship-adjusted retrospective likelihood approach.</p></fn><fn id="t1-fn3"><p><sup>†</sup>SNPs with more significant associations with ER-negative disease than known index SNPs from these loci.</p></fn></table-wrap-foot></table-wrap><table-wrap position="float" id="t2"><label>Table 2</label><caption><title>Novel associations of common genetic variants with ER-negative breast cancer risk.</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="char" char="."></col><col align="center"></col><col align="center"></col><col align="char" char="."></col><col align="center"></col><col align="char" char="."></col><col align="char" char="("></col><col align="left"></col><col align="char" char="."></col><col align="char" char="("></col><col align="left"></col><col align="left"></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50"> </th><th align="char" valign="top" char="." charoff="50"> </th><th align="center" valign="top" charoff="50"> </th><th align="center" valign="top" charoff="50"> </th><th align="char" valign="top" char="." charoff="50"> </th><th align="center" valign="top" charoff="50"> </th><th colspan="3" align="center" valign="top" char="." charoff="50"><bold>iCOGS/GWAS ER-negative</bold><hr></hr></th><th colspan="3" align="center" valign="top" char="." charoff="50"><bold>BRCA1 carriers</bold><hr></hr></th><th align="center" valign="top" charoff="50"><bold>Meta-analysis</bold></th></tr><tr><th align="center" valign="top" charoff="50"><bold>Location</bold></th><th align="center" valign="top" char="." charoff="50"><bold>Position</bold></th><th align="center" valign="top" charoff="50"><bold>Nearest gene</bold></th><th align="center" valign="top" charoff="50"><bold>SNP</bold></th><th align="center" valign="top" char="." charoff="50"><italic><bold>r</bold></italic><sup><bold>2</bold></sup></th><th align="center" valign="top" charoff="50"><bold>Allele</bold></th><th align="center" valign="top" char="." charoff="50"><bold>EAF</bold></th><th align="center" valign="top" char="(" charoff="50"><bold>OR (95% CI)</bold></th><th align="center" valign="top" charoff="50"><italic><bold>P</bold></italic><xref ref-type="fn" rid="t2-fn2">*</xref></th><th align="center" valign="top" char="." charoff="50"><bold>EAF</bold></th><th align="center" valign="top" char="(" charoff="50"><bold>HR (95% CI)</bold></th><th align="center" valign="top" charoff="50"><italic><bold>P</bold></italic><xref ref-type="fn" rid="t2-fn2">*</xref></th><th align="center" valign="top" charoff="50"><italic><bold>P</bold></italic><xref ref-type="fn" rid="t2-fn2">*</xref></th></tr></thead><tbody valign="top"><tr><td align="left" valign="top" charoff="50">2p23.2</td><td align="char" valign="top" char="." charoff="50">29119585</td><td align="center" valign="top" charoff="50"><italic>WDR43</italic></td><td align="center" valign="top" charoff="50">rs67073037</td><td align="char" valign="top" char="." charoff="50">0.98</td><td align="center" valign="top" charoff="50">A/T</td><td align="char" valign="top" char="." charoff="50">0.24</td><td align="char" valign="top" char="(" charoff="50">0.92 (0.88–0.95)</td><td align="left" valign="top" charoff="50">3.20 × 10<sup>−6</sup></td><td align="char" valign="top" char="." charoff="50">0.20</td><td align="char" valign="top" char="(" charoff="50">0.92 (0.87–0.96)</td><td align="left" valign="top" charoff="50">4.58 × 10<sup>−4</sup></td><td align="left" valign="top" charoff="50">4.76 × 10<sup>−9</sup></td></tr><tr><td align="left" valign="top" charoff="50">2p23.2</td><td align="char" valign="top" char="." charoff="50">29160421</td><td align="center" valign="top" charoff="50"><italic>WDR43</italic></td><td align="center" valign="top" charoff="50">rs6734079</td><td align="char" valign="top" char="." charoff="50">0.99</td><td align="center" valign="top" charoff="50">T/A</td><td align="char" valign="top" char="." charoff="50">0.23</td><td align="char" valign="top" char="(" charoff="50">0.92 (0.88–0.95)</td><td align="left" valign="top" charoff="50">3.99 × 10<sup>−6</sup></td><td align="char" valign="top" char="." charoff="50">0.20</td><td align="char" valign="top" char="(" charoff="50">0.92 (0.87–0.96)</td><td align="left" valign="top" charoff="50">4.55 × 10<sup>−4</sup></td><td align="left" valign="top" charoff="50">5.50 × 10<sup>−9</sup></td></tr><tr><td align="left" valign="top" charoff="50">2p23.2</td><td align="char" valign="top" char="." charoff="50">29120733</td><td align="center" valign="top" charoff="50"><italic>WDR43</italic></td><td align="center" valign="top" charoff="50">rs4577244</td><td align="char" valign="top" char="." charoff="50">1</td><td align="center" valign="top" charoff="50">C/T</td><td align="char" valign="top" char="." charoff="50">0.23</td><td align="char" valign="top" char="(" charoff="50">0.92 (0.89–0.95)</td><td align="left" valign="top" charoff="50">6.36 × 10<sup>−6</sup></td><td align="char" valign="top" char="." charoff="50">0.20</td><td align="char" valign="top" char="(" charoff="50">0.92 (0.88–0.96)</td><td align="left" valign="top" charoff="50">5.48 × 10<sup>−4</sup></td><td align="left" valign="top" charoff="50">1.05 × 10<sup>−8</sup></td></tr><tr><td align="left" valign="top" charoff="50"> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td align="left" valign="top" charoff="50">2q33</td><td align="char" valign="top" char="." charoff="50">201717014</td><td align="center" valign="top" charoff="50"><italic>CLK1</italic></td><td align="center" valign="top" charoff="50">rs74943274</td><td align="char" valign="top" char="." charoff="50">0.98</td><td align="center" valign="top" charoff="50">G/A</td><td align="char" valign="top" char="." charoff="50">0.015</td><td align="char" valign="top" char="(" charoff="50">1.34 (1.18–1.52)</td><td align="left" valign="top" charoff="50">5.89 × 10<sup>−6</sup></td><td align="char" valign="top" char="." charoff="50">0.02</td><td align="char" valign="top" char="(" charoff="50">1.20 (1.03–1.41)</td><td align="left" valign="top" charoff="50">0.012</td><td align="left" valign="top" charoff="50">6.00 × 10<sup>−7</sup></td></tr><tr><td align="left" valign="top" charoff="50">2q33</td><td align="char" valign="top" char="." charoff="50">201733341</td><td align="center" valign="top" charoff="50"><italic>CLK1/PPIL3</italic></td><td align="center" valign="top" charoff="50">rs188686860</td><td align="char" valign="top" char="." charoff="50">0.98</td><td align="center" valign="top" charoff="50">C/T</td><td align="char" valign="top" char="." charoff="50">0.016</td><td align="char" valign="top" char="(" charoff="50">1.36 (1.20–1.53)</td><td align="left" valign="top" charoff="50">1.16 × 10<sup>−6</sup></td><td align="char" valign="top" char="." charoff="50">0.02</td><td align="char" valign="top" char="(" charoff="50">1.22 (1.04–1.42)</td><td align="left" valign="top" charoff="50">0.012</td><td align="left" valign="top" charoff="50">8.34 × 10<sup>−8</sup></td></tr><tr><td align="left" valign="top" charoff="50">2q33</td><td align="char" valign="top" char="." charoff="50">201743594</td><td align="center" valign="top" charoff="50"><italic>PPIL3</italic></td><td align="center" valign="top" charoff="50">rs115635831</td><td align="char" valign="top" char="." charoff="50">1</td><td align="center" valign="top" charoff="50">G/A</td><td align="char" valign="top" char="." charoff="50">0.015</td><td align="char" valign="top" char="(" charoff="50">1.36 (1.20–1.54)</td><td align="left" valign="top" charoff="50">1.07 × 10<sup>−6</sup></td><td align="char" valign="top" char="." charoff="50">0.02</td><td align="char" valign="top" char="(" charoff="50">1.21 (1.03–1.41)</td><td align="left" valign="top" charoff="50">0.018</td><td align="left" valign="top" charoff="50">1.26 × 10<sup>−7</sup></td></tr><tr><td align="left" valign="top" charoff="50">2q33</td><td align="char" valign="top" char="." charoff="50">201935871</td><td align="center" valign="top" charoff="50"><italic>FAM126B/NDUFB3</italic></td><td align="center" valign="top" charoff="50">rs114962751</td><td align="char" valign="top" char="." charoff="50">1</td><td align="center" valign="top" charoff="50">T/A</td><td align="char" valign="top" char="." charoff="50">0.016</td><td align="char" valign="top" char="(" charoff="50">1.36 (1.20–1.53)</td><td align="left" valign="top" charoff="50">1.17 × 10<sup>−6</sup></td><td align="char" valign="top" char="." charoff="50">0.02</td><td align="char" valign="top" char="(" charoff="50">1.22 (1.05–1.42)</td><td align="left" valign="top" charoff="50">0.011</td><td align="left" valign="top" charoff="50">7.24 × 10<sup>−8</sup></td></tr><tr><td align="left" valign="top" charoff="50">13q22</td><td align="char" valign="top" char="." charoff="50">73957681</td><td align="center" valign="top" charoff="50"><italic>KLF5/KLF12</italic></td><td align="center" valign="top" charoff="50">rs6562760</td><td align="char" valign="top" char="." charoff="50">1</td><td align="center" valign="top" charoff="50">G/A</td><td align="char" valign="top" char="." charoff="50">0.23</td><td align="char" valign="top" char="(" charoff="50">0.92 (0.89–0.96)</td><td align="left" valign="top" charoff="50">1.85 × 10<sup>−5</sup></td><td align="char" valign="top" char="." charoff="50">0.20</td><td align="char" valign="top" char="(" charoff="50">0.89 (0.85–0.94)</td><td align="left" valign="top" charoff="50">2.85 × 10<sup>−6</sup></td><td align="left" valign="top" charoff="50">4.98 × 10<sup>−10</sup></td></tr><tr><td align="left" valign="top" charoff="50">13q22</td><td align="char" valign="top" char="." charoff="50">73960952</td><td align="center" valign="top" charoff="50"><italic>KLF5/KLF12</italic></td><td align="center" valign="top" charoff="50">rs2181965</td><td align="char" valign="top" char="." charoff="50">0.99</td><td align="center" valign="top" charoff="50">G/A</td><td align="char" valign="top" char="." charoff="50">0.23</td><td align="char" valign="top" char="(" charoff="50">0.92 (0.89–0.96)</td><td align="left" valign="top" charoff="50">2.16 × 10<sup>−5</sup></td><td align="char" valign="top" char="." charoff="50">0.20</td><td align="char" valign="top" char="(" charoff="50">0.89 (0.85–0.94)</td><td align="left" valign="top" charoff="50">2.39 × 10<sup>−6</sup></td><td align="left" valign="top" charoff="50">5.04 × 10<sup>−10</sup></td></tr><tr><td align="left" valign="top" charoff="50">13q22</td><td align="char" valign="top" char="." charoff="50">73964519</td><td align="center" valign="top" charoff="50"><italic>KLF5/KLF12</italic></td><td align="center" valign="top" charoff="50">rs8002929</td><td align="char" valign="top" char="." charoff="50">1</td><td align="center" valign="top" charoff="50">A/G</td><td align="char" valign="top" char="." charoff="50">0.23</td><td align="char" valign="top" char="(" charoff="50">0.93 (0.89–0.96)</td><td align="left" valign="top" charoff="50">2.52 × 10<sup>−5</sup></td><td align="char" valign="top" char="." charoff="50">0.20</td><td align="char" valign="top" char="(" charoff="50">0.89 (0.85–0.94)</td><td align="left" valign="top" charoff="50">1.71 × 10<sup>−6</sup></td><td align="left" valign="top" charoff="50">5.35 × 10<sup>−10</sup></td></tr><tr><td align="left" valign="top" charoff="50"> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td align="left" valign="top" charoff="50">13q22</td><td align="char" valign="top" char="." charoff="50">73806982</td><td align="center" valign="top" charoff="50"><italic>KLF5/KLF12</italic></td><td align="center" valign="top" charoff="50">rs12870942</td><td align="char" valign="top" char="." charoff="50">0.99</td><td align="center" valign="top" charoff="50">T/C</td><td align="char" valign="top" char="." charoff="50">0.32</td><td align="char" valign="top" char="(" charoff="50">1.09 (1.05–1.13)</td><td align="left" valign="top" charoff="50">2.71 × 10<sup>−7</sup></td><td align="char" valign="top" char="." charoff="50">0.30</td><td align="char" valign="top" char="(" charoff="50">1.06 (1.01–1.10)</td><td align="left" valign="top" charoff="50">0.01</td><td align="left" valign="top" charoff="50">3.75 × 10<sup>−8</sup></td></tr><tr><td align="left" valign="top" charoff="50">13q22</td><td align="char" valign="top" char="." charoff="50">73811471</td><td align="center" valign="top" charoff="50"><italic>KLF5/KLF12</italic></td><td align="center" valign="top" charoff="50">rs17181761</td><td align="char" valign="top" char="." charoff="50">0.99</td><td align="center" valign="top" charoff="50">A/C</td><td align="char" valign="top" char="." charoff="50">0.32</td><td align="char" valign="top" char="(" charoff="50">1.09 (1.05–1.12)</td><td align="left" valign="top" charoff="50">3.44 × 10<sup>−7</sup></td><td align="char" valign="top" char="." charoff="50">0.30</td><td align="char" valign="top" char="(" charoff="50">1.06 (1.01–1.10)</td><td align="left" valign="top" charoff="50">9.29 × 10<sup>−3</sup></td><td align="left" valign="top" charoff="50">4.23 × 10<sup>−8</sup></td></tr><tr><td align="left" valign="top" charoff="50">13q22</td><td align="char" valign="top" char="." charoff="50">73813803</td><td align="center" valign="top" charoff="50"><italic>KLF5/KLF12</italic></td><td align="center" valign="top" charoff="50">rs9573140</td><td align="char" valign="top" char="." charoff="50">1</td><td align="center" valign="top" charoff="50">A/G</td><td align="char" valign="top" char="." charoff="50">0.32</td><td align="char" valign="top" char="(" charoff="50">1.09 (1.05–1.12)</td><td align="left" valign="top" charoff="50">3.77 × 10<sup>−7</sup></td><td align="char" valign="top" char="." charoff="50">0.30</td><td align="char" valign="top" char="(" charoff="50">1.06 (1.01–1.10)</td><td align="left" valign="top" charoff="50">0.01</td><td align="left" valign="top" charoff="50">5.38 × 10<sup>−8</sup></td></tr></tbody></table><table-wrap-foot><fn id="t2-fn1"><p>CI, confidence interval; EAF, Effect allele frequency; ER, oestrogen receptor; GWAS, genome-wide association studies; HR, hazard ratio; OR, odds ratio; <italic>r</italic><sup>2</sup>, imputation accuracy; SNP, single-nucleotide polymorphism.</p></fn><fn id="t2-fn2"><p><sup>*</sup><italic>P</italic> values from iCOGS/BCAC and meta-analysis for ER-negative breast cancer were estimated by <italic>z</italic>-test. <italic>P</italic> values for <italic>BRCA1</italic> carriers were estimated by a kinship-adjusted retrospective likelihood approach.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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