Plasmodium falciparum Rab1A Localizes to Rhoptries in Schizonts
Identifieur interne : 000620 ( Pmc/Curation ); précédent : 000619; suivant : 000621Plasmodium falciparum Rab1A Localizes to Rhoptries in Schizonts
Auteurs : David Morse [Australie] ; Wesley Webster [Australie] ; Ming Kalanon [Australie] ; Gordon Langsley [France] ; Geoffrey I. Mcfadden [Australie]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
Abstract
Over-expression of a GFP-
Url:
DOI: 10.1371/journal.pone.0158174
PubMed: 27348424
PubMed Central: 4922565
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000621
Links to Exploration step
PMC:4922565Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>Plasmodium falciparum</italic>
Rab1A Localizes to Rhoptries in Schizonts</title>
<author><name sortKey="Morse, David" sort="Morse, David" uniqKey="Morse D" first="David" last="Morse">David Morse</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>School of BioSciences, University of Melbourne, Melbourne, VIC, 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of BioSciences, University of Melbourne, Melbourne, VIC, 3010</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Webster, Wesley" sort="Webster, Wesley" uniqKey="Webster W" first="Wesley" last="Webster">Wesley Webster</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>School of BioSciences, University of Melbourne, Melbourne, VIC, 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of BioSciences, University of Melbourne, Melbourne, VIC, 3010</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kalanon, Ming" sort="Kalanon, Ming" uniqKey="Kalanon M" first="Ming" last="Kalanon">Ming Kalanon</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>School of BioSciences, University of Melbourne, Melbourne, VIC, 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of BioSciences, University of Melbourne, Melbourne, VIC, 3010</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Langsley, Gordon" sort="Langsley, Gordon" uniqKey="Langsley G" first="Gordon" last="Langsley">Gordon Langsley</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Laboratoire de Biologie Cellulaire Comparative des Apicomplexes, Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, 75014, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Biologie Cellulaire Comparative des Apicomplexes, Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, 75014, Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mcfadden, Geoffrey I" sort="Mcfadden, Geoffrey I" uniqKey="Mcfadden G" first="Geoffrey I." last="Mcfadden">Geoffrey I. Mcfadden</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>School of BioSciences, University of Melbourne, Melbourne, VIC, 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of BioSciences, University of Melbourne, Melbourne, VIC, 3010</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">27348424</idno>
<idno type="pmc">4922565</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922565</idno>
<idno type="RBID">PMC:4922565</idno>
<idno type="doi">10.1371/journal.pone.0158174</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">000621</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000621</idno>
<idno type="wicri:Area/Pmc/Curation">000620</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000620</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>Plasmodium falciparum</italic>
Rab1A Localizes to Rhoptries in Schizonts</title>
<author><name sortKey="Morse, David" sort="Morse, David" uniqKey="Morse D" first="David" last="Morse">David Morse</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>School of BioSciences, University of Melbourne, Melbourne, VIC, 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of BioSciences, University of Melbourne, Melbourne, VIC, 3010</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Webster, Wesley" sort="Webster, Wesley" uniqKey="Webster W" first="Wesley" last="Webster">Wesley Webster</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>School of BioSciences, University of Melbourne, Melbourne, VIC, 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of BioSciences, University of Melbourne, Melbourne, VIC, 3010</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kalanon, Ming" sort="Kalanon, Ming" uniqKey="Kalanon M" first="Ming" last="Kalanon">Ming Kalanon</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>School of BioSciences, University of Melbourne, Melbourne, VIC, 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of BioSciences, University of Melbourne, Melbourne, VIC, 3010</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Langsley, Gordon" sort="Langsley, Gordon" uniqKey="Langsley G" first="Gordon" last="Langsley">Gordon Langsley</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Laboratoire de Biologie Cellulaire Comparative des Apicomplexes, Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, 75014, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Biologie Cellulaire Comparative des Apicomplexes, Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, 75014, Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mcfadden, Geoffrey I" sort="Mcfadden, Geoffrey I" uniqKey="Mcfadden G" first="Geoffrey I." last="Mcfadden">Geoffrey I. Mcfadden</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>School of BioSciences, University of Melbourne, Melbourne, VIC, 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of BioSciences, University of Melbourne, Melbourne, VIC, 3010</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Over-expression of a GFP-<italic>Pf</italic>
Rab1A fusion protein in <italic>Plasmodium falciparum</italic>
schizonts produces a punctate pattern of fluorescence typical of rhoptries, secretory organelles involved in host cell invasion. The GFP-positive bodies were purified by a combination of differential and density gradient centrifugation and their protein content determined by MS/MS sequencing. Consistent with the GFP rhoptry-like pattern of transgenic parasites, four of the 19 proteins identified have been previously described to be rhoptry-associated and another four are ER or ER-associated proteins. Confirmation that GFP-<italic>Pf</italic>
Rab1A decorates rhoptries was obtained by its co-localization with Rap1 and Ron4 in late phase schizonts. We conclude that <italic>Pf</italic>
Rab1A potentially regulates vesicular traffic from the endoplasmic reticulum to the rhoptries in <italic>Apicomplexa</italic>
parasites.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cowman, Af" uniqKey="Cowman A">AF Cowman</name>
</author>
<author><name sortKey="Crabb, Bs" uniqKey="Crabb B">BS Crabb</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Waller, Rf" uniqKey="Waller R">RF Waller</name>
</author>
<author><name sortKey="Mcfadden, Gi" uniqKey="Mcfadden G">GI McFadden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ralph, Sa" uniqKey="Ralph S">SA Ralph</name>
</author>
<author><name sortKey="Van Dooren, Gg" uniqKey="Van Dooren G">GG Van Dooren</name>
</author>
<author><name sortKey="Waller, Rf" uniqKey="Waller R">RF Waller</name>
</author>
<author><name sortKey="Crawford, Mj" uniqKey="Crawford M">MJ Crawford</name>
</author>
<author><name sortKey="Fraunholz, Mj" uniqKey="Fraunholz M">MJ Fraunholz</name>
</author>
<author><name sortKey="Foth, Bj" uniqKey="Foth B">BJ Foth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kats, Lm" uniqKey="Kats L">LM Kats</name>
</author>
<author><name sortKey="Black, Cg" uniqKey="Black C">CG Black</name>
</author>
<author><name sortKey="Proellocks, Ni" uniqKey="Proellocks N">NI Proellocks</name>
</author>
<author><name sortKey="Coppel, Rl" uniqKey="Coppel R">RL Coppel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Soldati, D" uniqKey="Soldati D">D Soldati</name>
</author>
<author><name sortKey="Dubremetz, Jf" uniqKey="Dubremetz J">JF Dubremetz</name>
</author>
<author><name sortKey="Lebrun, M" uniqKey="Lebrun M">M Lebrun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mercier, C" uniqKey="Mercier C">C Mercier</name>
</author>
<author><name sortKey="Adjogble, Kd" uniqKey="Adjogble K">KD Adjogble</name>
</author>
<author><name sortKey="Daubener, W" uniqKey="Daubener W">W Daubener</name>
</author>
<author><name sortKey="Delauw, Mf" uniqKey="Delauw M">MF Delauw</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Counihan, Na" uniqKey="Counihan N">NA Counihan</name>
</author>
<author><name sortKey="Kalanon, M" uniqKey="Kalanon M">M Kalanon</name>
</author>
<author><name sortKey="Coppel, Rl" uniqKey="Coppel R">RL Coppel</name>
</author>
<author><name sortKey="De Koning Ward, Tf" uniqKey="De Koning Ward T">TF de Koning-Ward</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bonifacino, Js" uniqKey="Bonifacino J">JS Bonifacino</name>
</author>
<author><name sortKey="Glick, Bs" uniqKey="Glick B">BS Glick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Vliet, C" uniqKey="Van Vliet C">C van Vliet</name>
</author>
<author><name sortKey="Thomas, Ec" uniqKey="Thomas E">EC Thomas</name>
</author>
<author><name sortKey="Merino Trigo, A" uniqKey="Merino Trigo A">A Merino-Trigo</name>
</author>
<author><name sortKey="Teasdale, Rd" uniqKey="Teasdale R">RD Teasdale</name>
</author>
<author><name sortKey="Gleeson, Pa" uniqKey="Gleeson P">PA Gleeson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sudhof, Tc" uniqKey="Sudhof T">TC Sudhof</name>
</author>
<author><name sortKey="Rothman, Je" uniqKey="Rothman J">JE Rothman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cai, H" uniqKey="Cai H">H Cai</name>
</author>
<author><name sortKey="Reinisch, K" uniqKey="Reinisch K">K Reinisch</name>
</author>
<author><name sortKey="Ferro Novick, S" uniqKey="Ferro Novick S">S Ferro-Novick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Buvelot Frei, S" uniqKey="Buvelot Frei S">S Buvelot Frei</name>
</author>
<author><name sortKey="Rahl, Pb" uniqKey="Rahl P">PB Rahl</name>
</author>
<author><name sortKey="Nussbaum, M" uniqKey="Nussbaum M">M Nussbaum</name>
</author>
<author><name sortKey="Briggs, Bj" uniqKey="Briggs B">BJ Briggs</name>
</author>
<author><name sortKey="Calero, M" uniqKey="Calero M">M Calero</name>
</author>
<author><name sortKey="Janeczko, S" uniqKey="Janeczko S">S Janeczko</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Quevillon, E" uniqKey="Quevillon E">E Quevillon</name>
</author>
<author><name sortKey="Spielmann, T" uniqKey="Spielmann T">T Spielmann</name>
</author>
<author><name sortKey="Brahimi, K" uniqKey="Brahimi K">K Brahimi</name>
</author>
<author><name sortKey="Chattopadhyay, D" uniqKey="Chattopadhyay D">D Chattopadhyay</name>
</author>
<author><name sortKey="Yeramian, E" uniqKey="Yeramian E">E Yeramian</name>
</author>
<author><name sortKey="Langsley, G" uniqKey="Langsley G">G Langsley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stenmark, H" uniqKey="Stenmark H">H Stenmark</name>
</author>
<author><name sortKey="Olkkonen, Vm" uniqKey="Olkkonen V">VM Olkkonen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rutherford, S" uniqKey="Rutherford S">S Rutherford</name>
</author>
<author><name sortKey="Moore, I" uniqKey="Moore I">I Moore</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Collins, Rn" uniqKey="Collins R">RN Collins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Segev, N" uniqKey="Segev N">N Segev</name>
</author>
<author><name sortKey="Mulholland, J" uniqKey="Mulholland J">J Mulholland</name>
</author>
<author><name sortKey="Botstein, D" uniqKey="Botstein D">D Botstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Singer Kruger, B" uniqKey="Singer Kruger B">B Singer-Kruger</name>
</author>
<author><name sortKey="Stenmark, H" uniqKey="Stenmark H">H Stenmark</name>
</author>
<author><name sortKey="Zerial, M" uniqKey="Zerial M">M Zerial</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mallard, F" uniqKey="Mallard F">F Mallard</name>
</author>
<author><name sortKey="Tang, Bl" uniqKey="Tang B">BL Tang</name>
</author>
<author><name sortKey="Galli, T" uniqKey="Galli T">T Galli</name>
</author>
<author><name sortKey="Tenza, D" uniqKey="Tenza D">D Tenza</name>
</author>
<author><name sortKey="Saint Pol, A" uniqKey="Saint Pol A">A Saint-Pol</name>
</author>
<author><name sortKey="Yue, X" uniqKey="Yue X">X Yue</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bucci, C" uniqKey="Bucci C">C Bucci</name>
</author>
<author><name sortKey="Parton, Rg" uniqKey="Parton R">RG Parton</name>
</author>
<author><name sortKey="Mather, Ih" uniqKey="Mather I">IH Mather</name>
</author>
<author><name sortKey="Stunnenberg, H" uniqKey="Stunnenberg H">H Stunnenberg</name>
</author>
<author><name sortKey="Simons, K" uniqKey="Simons K">K Simons</name>
</author>
<author><name sortKey="Hoflack, B" uniqKey="Hoflack B">B Hoflack</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Elias, M" uniqKey="Elias M">M Elias</name>
</author>
<author><name sortKey="Patron, Nj" uniqKey="Patron N">NJ Patron</name>
</author>
<author><name sortKey="Keeling, Pj" uniqKey="Keeling P">PJ Keeling</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kremer, K" uniqKey="Kremer K">K Kremer</name>
</author>
<author><name sortKey="Kamin, D" uniqKey="Kamin D">D Kamin</name>
</author>
<author><name sortKey="Rittweger, E" uniqKey="Rittweger E">E Rittweger</name>
</author>
<author><name sortKey="Wilkes, J" uniqKey="Wilkes J">J Wilkes</name>
</author>
<author><name sortKey="Flammer, H" uniqKey="Flammer H">H Flammer</name>
</author>
<author><name sortKey="Mahler, S" uniqKey="Mahler S">S Mahler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kaderi Kibria, Km" uniqKey="Kaderi Kibria K">KM Kaderi Kibria</name>
</author>
<author><name sortKey="Rawat, K" uniqKey="Rawat K">K Rawat</name>
</author>
<author><name sortKey="Klinger, Cm" uniqKey="Klinger C">CM Klinger</name>
</author>
<author><name sortKey="Datta, G" uniqKey="Datta G">G Datta</name>
</author>
<author><name sortKey="Panchal, M" uniqKey="Panchal M">M Panchal</name>
</author>
<author><name sortKey="Singh, S" uniqKey="Singh S">S Singh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name>
</author>
<author><name sortKey="Schulze, Kl" uniqKey="Schulze K">KL Schulze</name>
</author>
<author><name sortKey="Hiesinger, Pr" uniqKey="Hiesinger P">PR Hiesinger</name>
</author>
<author><name sortKey="Suyama, K" uniqKey="Suyama K">K Suyama</name>
</author>
<author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name>
</author>
<author><name sortKey="Fish, M" uniqKey="Fish M">M Fish</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Herm Gotz, A" uniqKey="Herm Gotz A">A Herm-Gotz</name>
</author>
<author><name sortKey="Agop Nersesian, C" uniqKey="Agop Nersesian C">C Agop-Nersesian</name>
</author>
<author><name sortKey="Munter, S" uniqKey="Munter S">S Munter</name>
</author>
<author><name sortKey="Grimley, Js" uniqKey="Grimley J">JS Grimley</name>
</author>
<author><name sortKey="Wandless, Tj" uniqKey="Wandless T">TJ Wandless</name>
</author>
<author><name sortKey="Frischknecht, F" uniqKey="Frischknecht F">F Frischknecht</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tonkin, Cj" uniqKey="Tonkin C">CJ Tonkin</name>
</author>
<author><name sortKey="Van Dooren, Gg" uniqKey="Van Dooren G">GG van Dooren</name>
</author>
<author><name sortKey="Spurck, Tp" uniqKey="Spurck T">TP Spurck</name>
</author>
<author><name sortKey="Struck, Ns" uniqKey="Struck N">NS Struck</name>
</author>
<author><name sortKey="Good, Rt" uniqKey="Good R">RT Good</name>
</author>
<author><name sortKey="Handman, E" uniqKey="Handman E">E Handman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Waller, Rf" uniqKey="Waller R">RF Waller</name>
</author>
<author><name sortKey="Reed, Mb" uniqKey="Reed M">MB Reed</name>
</author>
<author><name sortKey="Cowman, Af" uniqKey="Cowman A">AF Cowman</name>
</author>
<author><name sortKey="Mcfadden, Gi" uniqKey="Mcfadden G">GI McFadden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Richard, D" uniqKey="Richard D">D Richard</name>
</author>
<author><name sortKey="Kats, Lm" uniqKey="Kats L">LM Kats</name>
</author>
<author><name sortKey="Langer, C" uniqKey="Langer C">C Langer</name>
</author>
<author><name sortKey="Black, Cg" uniqKey="Black C">CG Black</name>
</author>
<author><name sortKey="Mitri, K" uniqKey="Mitri K">K Mitri</name>
</author>
<author><name sortKey="Boddey, Ja" uniqKey="Boddey J">JA Boddey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mesa, R" uniqKey="Mesa R">R Mesa</name>
</author>
<author><name sortKey="Salomon, C" uniqKey="Salomon C">C Salomon</name>
</author>
<author><name sortKey="Roggero, M" uniqKey="Roggero M">M Roggero</name>
</author>
<author><name sortKey="Stahl, Pd" uniqKey="Stahl P">PD Stahl</name>
</author>
<author><name sortKey="Mayorga, Ls" uniqKey="Mayorga L">LS Mayorga</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Roberts, Rl" uniqKey="Roberts R">RL Roberts</name>
</author>
<author><name sortKey="Barbieri, Ma" uniqKey="Barbieri M">MA Barbieri</name>
</author>
<author><name sortKey="Pryse, Km" uniqKey="Pryse K">KM Pryse</name>
</author>
<author><name sortKey="Chua, M" uniqKey="Chua M">M Chua</name>
</author>
<author><name sortKey="Morisaki, Jh" uniqKey="Morisaki J">JH Morisaki</name>
</author>
<author><name sortKey="Stahl, Pd" uniqKey="Stahl P">PD Stahl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Welter, Bh" uniqKey="Welter B">BH Welter</name>
</author>
<author><name sortKey="Temesvari, La" uniqKey="Temesvari L">LA Temesvari</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martinez, O" uniqKey="Martinez O">O Martinez</name>
</author>
<author><name sortKey="Antony, C" uniqKey="Antony C">C Antony</name>
</author>
<author><name sortKey="Pehau Arnaudet, G" uniqKey="Pehau Arnaudet G">G Pehau-Arnaudet</name>
</author>
<author><name sortKey="Berger, Eg" uniqKey="Berger E">EG Berger</name>
</author>
<author><name sortKey="Salamero, J" uniqKey="Salamero J">J Salamero</name>
</author>
<author><name sortKey="Goud, B" uniqKey="Goud B">B Goud</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Peter, F" uniqKey="Peter F">F Peter</name>
</author>
<author><name sortKey="Nuoffer, C" uniqKey="Nuoffer C">C Nuoffer</name>
</author>
<author><name sortKey="Pind, Sn" uniqKey="Pind S">SN Pind</name>
</author>
<author><name sortKey="Balch, We" uniqKey="Balch W">WE Balch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saraste, J" uniqKey="Saraste J">J Saraste</name>
</author>
<author><name sortKey="Lahtinen, U" uniqKey="Lahtinen U">U Lahtinen</name>
</author>
<author><name sortKey="Goud, B" uniqKey="Goud B">B Goud</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jin, M" uniqKey="Jin M">M Jin</name>
</author>
<author><name sortKey="Saucan, L" uniqKey="Saucan L">L Saucan</name>
</author>
<author><name sortKey="Farquhar, Mg" uniqKey="Farquhar M">MG Farquhar</name>
</author>
<author><name sortKey="Palade, Ge" uniqKey="Palade G">GE Palade</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sannerud, R" uniqKey="Sannerud R">R Sannerud</name>
</author>
<author><name sortKey="Marie, M" uniqKey="Marie M">M Marie</name>
</author>
<author><name sortKey="Nizak, C" uniqKey="Nizak C">C Nizak</name>
</author>
<author><name sortKey="Dale, Ha" uniqKey="Dale H">HA Dale</name>
</author>
<author><name sortKey="Pernet Gallay, K" uniqKey="Pernet Gallay K">K Pernet-Gallay</name>
</author>
<author><name sortKey="Perez, F" uniqKey="Perez F">F Perez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sloves, Pj" uniqKey="Sloves P">PJ Sloves</name>
</author>
<author><name sortKey="Delhaye, S" uniqKey="Delhaye S">S Delhaye</name>
</author>
<author><name sortKey="Mouveaux, T" uniqKey="Mouveaux T">T Mouveaux</name>
</author>
<author><name sortKey="Werkmeister, E" uniqKey="Werkmeister E">E Werkmeister</name>
</author>
<author><name sortKey="Slomianny, C" uniqKey="Slomianny C">C Slomianny</name>
</author>
<author><name sortKey="Hovasse, A" uniqKey="Hovasse A">A Hovasse</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weir, Ml" uniqKey="Weir M">ML Weir</name>
</author>
<author><name sortKey="Xie, H" uniqKey="Xie H">H Xie</name>
</author>
<author><name sortKey="Klip, A" uniqKey="Klip A">A Klip</name>
</author>
<author><name sortKey="Trimble, Ws" uniqKey="Trimble W">WS Trimble</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lacount, Dj" uniqKey="Lacount D">DJ LaCount</name>
</author>
<author><name sortKey="Vignali, M" uniqKey="Vignali M">M Vignali</name>
</author>
<author><name sortKey="Chettier, R" uniqKey="Chettier R">R Chettier</name>
</author>
<author><name sortKey="Phansalkar, A" uniqKey="Phansalkar A">A Phansalkar</name>
</author>
<author><name sortKey="Bell, R" uniqKey="Bell R">R Bell</name>
</author>
<author><name sortKey="Hesselberth, Jr" uniqKey="Hesselberth J">JR Hesselberth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gong, Y" uniqKey="Gong Y">Y Gong</name>
</author>
<author><name sortKey="Kakihara, Y" uniqKey="Kakihara Y">Y Kakihara</name>
</author>
<author><name sortKey="Krogan, N" uniqKey="Krogan N">N Krogan</name>
</author>
<author><name sortKey="Greenblatt, J" uniqKey="Greenblatt J">J Greenblatt</name>
</author>
<author><name sortKey="Emili, A" uniqKey="Emili A">A Emili</name>
</author>
<author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mateyak, Mk" uniqKey="Mateyak M">MK Mateyak</name>
</author>
<author><name sortKey="Kinzy, Tg" uniqKey="Kinzy T">TG Kinzy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sanders, Pr" uniqKey="Sanders P">PR Sanders</name>
</author>
<author><name sortKey="Gilson, Pr" uniqKey="Gilson P">PR Gilson</name>
</author>
<author><name sortKey="Cantin, Gt" uniqKey="Cantin G">GT Cantin</name>
</author>
<author><name sortKey="Greenbaum, Dc" uniqKey="Greenbaum D">DC Greenbaum</name>
</author>
<author><name sortKey="Nebl, T" uniqKey="Nebl T">T Nebl</name>
</author>
<author><name sortKey="Carucci, Dj" uniqKey="Carucci D">DJ Carucci</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boothroyd, Jc" uniqKey="Boothroyd J">JC Boothroyd</name>
</author>
<author><name sortKey="Dubremetz, Jf" uniqKey="Dubremetz J">JF Dubremetz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jaikaria, Ns" uniqKey="Jaikaria N">NS Jaikaria</name>
</author>
<author><name sortKey="Rozario, C" uniqKey="Rozario C">C Rozario</name>
</author>
<author><name sortKey="Ridley, Rg" uniqKey="Ridley R">RG Ridley</name>
</author>
<author><name sortKey="Perkins, Me" uniqKey="Perkins M">ME Perkins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ngo, Hm" uniqKey="Ngo H">HM Ngo</name>
</author>
<author><name sortKey="Yang, M" uniqKey="Yang M">M Yang</name>
</author>
<author><name sortKey="Paprotka, K" uniqKey="Paprotka K">K Paprotka</name>
</author>
<author><name sortKey="Pypaert, M" uniqKey="Pypaert M">M Pypaert</name>
</author>
<author><name sortKey="Hoppe, H" uniqKey="Hoppe H">H Hoppe</name>
</author>
<author><name sortKey="Joiner, Ka" uniqKey="Joiner K">KA Joiner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Breinich, Ms" uniqKey="Breinich M">MS Breinich</name>
</author>
<author><name sortKey="Ferguson, Dj" uniqKey="Ferguson D">DJ Ferguson</name>
</author>
<author><name sortKey="Foth, Bj" uniqKey="Foth B">BJ Foth</name>
</author>
<author><name sortKey="Van Dooren, Gg" uniqKey="Van Dooren G">GG van Dooren</name>
</author>
<author><name sortKey="Lebrun, M" uniqKey="Lebrun M">M Lebrun</name>
</author>
<author><name sortKey="Quon, Dv" uniqKey="Quon D">DV Quon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bannister, Lh" uniqKey="Bannister L">LH Bannister</name>
</author>
<author><name sortKey="Hopkins, Jm" uniqKey="Hopkins J">JM Hopkins</name>
</author>
<author><name sortKey="Fowler, Re" uniqKey="Fowler R">RE Fowler</name>
</author>
<author><name sortKey="Krishna, S" uniqKey="Krishna S">S Krishna</name>
</author>
<author><name sortKey="Mitchell, Gh" uniqKey="Mitchell G">GH Mitchell</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id>
<journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id>
<journal-id journal-id-type="publisher-id">plos</journal-id>
<journal-id journal-id-type="pmc">plosone</journal-id>
<journal-title-group><journal-title>PLoS ONE</journal-title>
</journal-title-group>
<issn pub-type="epub">1932-6203</issn>
<publisher><publisher-name>Public Library of Science</publisher-name>
<publisher-loc>San Francisco, CA USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">27348424</article-id>
<article-id pub-id-type="pmc">4922565</article-id>
<article-id pub-id-type="doi">10.1371/journal.pone.0158174</article-id>
<article-id pub-id-type="publisher-id">PONE-D-16-14978</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Cell Biology</subject>
<subj-group><subject>Cellular Structures and Organelles</subject>
<subj-group><subject>Cell Membranes</subject>
<subj-group><subject>Membrane Proteins</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Cell Biology</subject>
<subj-group><subject>Cellular Structures and Organelles</subject>
<subj-group><subject>Cell Membranes</subject>
<subj-group><subject>Membrane Proteins</subject>
<subj-group><subject>Integral Membrane Proteins</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Parasitology</subject>
<subj-group><subject>Parasite Groups</subject>
<subj-group><subject>Apicomplexa</subject>
<subj-group><subject>Plasmodium</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Cell Biology</subject>
<subj-group><subject>Cellular Structures and Organelles</subject>
<subj-group><subject>Endoplasmic Reticulum</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Cell Biology</subject>
<subj-group><subject>Cell Processes</subject>
<subj-group><subject>Secretory Pathway</subject>
<subj-group><subject>Endoplasmic Reticulum</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Cell Biology</subject>
<subj-group><subject>Cellular Structures and Organelles</subject>
<subj-group><subject>Vesicles</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and life sciences</subject>
<subj-group><subject>Biochemistry</subject>
<subj-group><subject>Proteins</subject>
<subj-group><subject>DNA-binding proteins</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Molecular Biology</subject>
<subj-group><subject>Molecular Biology Techniques</subject>
<subj-group><subject>Cloning</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Research and Analysis Methods</subject>
<subj-group><subject>Molecular Biology Techniques</subject>
<subj-group><subject>Cloning</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Organisms</subject>
<subj-group><subject>Protozoans</subject>
<subj-group><subject>Parasitic Protozoans</subject>
<subj-group><subject>Malarial Parasites</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title><italic>Plasmodium falciparum</italic>
Rab1A Localizes to Rhoptries in Schizonts</article-title>
<alt-title alt-title-type="running-head">PfRab1A and Rhoptry Protein Targeting</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Morse</surname>
<given-names>David</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="currentaff001"><sup>¤a</sup>
</xref>
<xref ref-type="corresp" rid="cor001">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Webster</surname>
<given-names>Wesley</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="currentaff002"><sup>¤b</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kalanon</surname>
<given-names>Ming</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="currentaff003"><sup>¤c</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Langsley</surname>
<given-names>Gordon</given-names>
</name>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>McFadden</surname>
<given-names>Geoffrey I.</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
</contrib-group>
<aff id="aff001"><label>1</label>
<addr-line>School of BioSciences, University of Melbourne, Melbourne, VIC, 3010, Australia</addr-line>
</aff>
<aff id="aff002"><label>2</label>
<addr-line>Laboratoire de Biologie Cellulaire Comparative des Apicomplexes, Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, 75014, Paris, France</addr-line>
</aff>
<contrib-group><contrib contrib-type="editor"><name><surname>Tsuboi</surname>
<given-names>Takafumi</given-names>
</name>
<role>Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1"><addr-line>Ehime University, JAPAN</addr-line>
</aff>
<author-notes><fn fn-type="conflict" id="coi001"><p><bold>Competing Interests: </bold>
The authors have declared that no competing interests exist</p>
</fn>
<fn fn-type="con" id="contrib001"><p>Conceived and designed the experiments: DM, GL, GM. Performed the experiments: DM, WW. Analyzed the data: DM, MK, GL, GM. Contributed reagents/materials/analysis tools: DM, GL, GM. Wrote the paper: DM, GL.</p>
</fn>
<fn fn-type="current-aff" id="currentaff001"><label>¤a</label>
<p>Current address: On leave from the Institut de recherche en biologie végétale, Département de Sciences biologiques, Université de Montréal, Montréal, Canada</p>
</fn>
<fn fn-type="current-aff" id="currentaff002"><label>¤b</label>
<p>Current address: Centre for Regional and Rural Futures, Deakin University, Burwood, Australia</p>
</fn>
<fn fn-type="current-aff" id="currentaff003"><label>¤c</label>
<p>Current address: Faculty of Law, Deakin University, Burwood, Australia</p>
</fn>
<corresp id="cor001">* E-mail: <email>david.morse@umontreal.ca</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>27</day>
<month>6</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="collection"><year>2016</year>
</pub-date>
<volume>11</volume>
<issue>6</issue>
<elocation-id>e0158174</elocation-id>
<history><date date-type="received"><day>13</day>
<month>4</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>11</day>
<month>6</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>© 2016 Morse et al</copyright-statement>
<copyright-year>2016</copyright-year>
<copyright-holder>Morse et al</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>
, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:href="pone.0158174.pdf"></self-uri>
<abstract><p>Over-expression of a GFP-<italic>Pf</italic>
Rab1A fusion protein in <italic>Plasmodium falciparum</italic>
schizonts produces a punctate pattern of fluorescence typical of rhoptries, secretory organelles involved in host cell invasion. The GFP-positive bodies were purified by a combination of differential and density gradient centrifugation and their protein content determined by MS/MS sequencing. Consistent with the GFP rhoptry-like pattern of transgenic parasites, four of the 19 proteins identified have been previously described to be rhoptry-associated and another four are ER or ER-associated proteins. Confirmation that GFP-<italic>Pf</italic>
Rab1A decorates rhoptries was obtained by its co-localization with Rap1 and Ron4 in late phase schizonts. We conclude that <italic>Pf</italic>
Rab1A potentially regulates vesicular traffic from the endoplasmic reticulum to the rhoptries in <italic>Apicomplexa</italic>
parasites.</p>
</abstract>
<funding-group><award-group id="award001"><funding-source><institution-wrap><institution-id institution-id-type="funder-id">http://dx.doi.org/10.13039/100000025</institution-id>
<institution>National Institute of Mental Health</institution>
</institution-wrap>
</funding-source>
<principal-award-recipient>Geoff I. McFadden</principal-award-recipient>
</award-group>
<award-group id="award002"><funding-source><institution>Howard Hughes Medical Institute (US)</institution>
</funding-source>
<principal-award-recipient>Geoff I. McFadden</principal-award-recipient>
</award-group>
<award-group id="award003"><funding-source><institution>Labex ParaFrap</institution>
</funding-source>
<award-id>ANR-11-LABX-0024</award-id>
<principal-award-recipient><name><surname>Langsley</surname>
<given-names>Gordon</given-names>
</name>
</principal-award-recipient>
</award-group>
<funding-statement>Funded by National Health and Medical Research Council (Australia); Australian Research Council; Labex ParaFrap - ANR-11-LABX-0024. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement>
</funding-group>
<counts><fig-count count="3"></fig-count>
<table-count count="1"></table-count>
<page-count count="13"></page-count>
</counts>
<custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name>
<meta-value>All relevant data are within the paper and its Supporting Information files.</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
<notes><title>Data Availability</title>
<p>All relevant data are within the paper and its Supporting Information files.</p>
</notes>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000620 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000620 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:4922565 |texte= Plasmodium falciparum Rab1A Localizes to Rhoptries in Schizonts }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:27348424" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |