Multidimensional analysis of the effect of occupational exposure to organic solvents on lung cancer risk: the ICARE study
Identifieur interne : 000568 ( Pmc/Curation ); précédent : 000567; suivant : 000569Multidimensional analysis of the effect of occupational exposure to organic solvents on lung cancer risk: the ICARE study
Auteurs : Francesca Mattei [France] ; Silvia Liverani [Royaume-Uni] ; Florence Guida [Royaume-Uni] ; Mireille Matrat [France] ; Sylvie Cenée [France] ; Lamiae Azizi [Australie] ; Gwenn Menvielle [France] ; Marie Sanchez [France] ; Corinne Pilorget [France] ; Bénédicte Lapôtre-Ledoux [France] ; Danièle Luce [France] ; Sylvia Richardson [Royaume-Uni] ; Isabelle Stücker [France]Source :
- Occupational and Environmental Medicine [ 1351-0711 ] ; 2016.
Abstract
The association between lung cancer and occupational exposure to organic solvents is discussed. Since different solvents are often used
The present study is focused on an in-depth investigation of the potential association between lung cancer risk and occupational exposure to a large group of organic solvents, taking into account the well-known risk factors for lung cancer, tobacco smoking and occupational exposure to asbestos.
We analysed data from the Investigation of occupational and environmental causes of respiratory cancers (ICARE) study, a large French population-based case–control study, set up between 2001 and 2007. A total of 2276 male cases and 2780 male controls were interviewed, and long-life occupational history was collected. In order to overcome the analytical difficulties created by multiple correlated exposures, we carried out a novel type of analysis based on Bayesian profile regression.
After analysis with conventional logistic regression methods, none of the 11 solvents examined were associated with lung cancer risk. Through a profile regression approach, we did not observe any significant association between solvent exposure and lung cancer. However, we identified clusters at high risk that are related to occupations known to be at risk of developing lung cancer, such as painters.
Organic solvents do not appear to be substantial contributors to the occupational risk of lung cancer for the occupations known to be at risk.
Url:
DOI: 10.1136/oemed-2015-103177
PubMed: 26911986
PubMed Central: 4893113
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Paris-Sud, UVSQ, CESP, INSERM</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liverani, Silvia" sort="Liverani, Silvia" uniqKey="Liverani S" first="Silvia" last="Liverani">Silvia Liverani</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Mathematics</addr-line>,<institution>Brunel University London</institution>,<addr-line>Uxbridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>MRC Biostatistics Unit</addr-line>,<institution>Cambridge Institute of Public Health, Cambridge Biomedical Campus</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guida, Florence" sort="Guida, Florence" uniqKey="Guida F" first="Florence" last="Guida">Florence Guida</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Imperial College London, MRC-PHE Centre for Environment and Health, School of Public Health</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Matrat, Mireille" sort="Matrat, Mireille" uniqKey="Matrat M" first="Mireille" last="Matrat">Mireille Matrat</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Université Paris Saclay, Univ. 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Paris-Sud, UVSQ, CESP, INSERM</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pilorget, Corinne" sort="Pilorget, Corinne" uniqKey="Pilorget C" first="Corinne" last="Pilorget">Corinne Pilorget</name><affiliation wicri:level="1"><nlm:aff id="af9"><institution>French Institute for Public Health Surveillance</institution>,<addr-line>Saint-Maurice</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af10"><addr-line>Epidemiological research and surveillance unit in transport, occupation and environment</addr-line>,<institution>Claude Bernard Lyon1 University</institution>,<addr-line>Lyon</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lapotre Ledoux, Benedicte" sort="Lapotre Ledoux, Benedicte" uniqKey="Lapotre Ledoux B" first="Bénédicte" last="Lapôtre-Ledoux">Bénédicte Lapôtre-Ledoux</name><affiliation wicri:level="1"><nlm:aff id="af11"><institution>Somme Cancer Registry</institution>,<addr-line>Amiens</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Luce, Daniele" sort="Luce, Daniele" uniqKey="Luce D" first="Danièle" last="Luce">Danièle Luce</name><affiliation wicri:level="1"><nlm:aff id="af12"><institution>INSERM, U 1085_IRSET</institution>,<addr-line>Pointe-à-Pitre</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>University of Rennes 1</institution>,<addr-line>Rennes</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Richardson, Sylvia" sort="Richardson, Sylvia" uniqKey="Richardson S" first="Sylvia" last="Richardson">Sylvia Richardson</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>MRC Biostatistics Unit</addr-line>,<institution>Cambridge Institute of Public Health, Cambridge Biomedical Campus</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stucker, Isabelle" sort="Stucker, Isabelle" uniqKey="Stucker I" first="Isabelle" last="Stücker">Isabelle Stücker</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Université Paris Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26911986</idno><idno type="pmc">4893113</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893113</idno><idno type="RBID">PMC:4893113</idno><idno type="doi">10.1136/oemed-2015-103177</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000568</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000568</idno><idno type="wicri:Area/Pmc/Curation">000568</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000568</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Multidimensional analysis of the effect of occupational exposure to organic solvents on lung cancer risk: the ICARE study</title><author><name sortKey="Mattei, Francesca" sort="Mattei, Francesca" uniqKey="Mattei F" first="Francesca" last="Mattei">Francesca Mattei</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Université Paris Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liverani, Silvia" sort="Liverani, Silvia" uniqKey="Liverani S" first="Silvia" last="Liverani">Silvia Liverani</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Mathematics</addr-line>,<institution>Brunel University London</institution>,<addr-line>Uxbridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>MRC Biostatistics Unit</addr-line>,<institution>Cambridge Institute of Public Health, Cambridge Biomedical Campus</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guida, Florence" sort="Guida, Florence" uniqKey="Guida F" first="Florence" last="Guida">Florence Guida</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Imperial College London, MRC-PHE Centre for Environment and Health, School of Public Health</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Matrat, Mireille" sort="Matrat, Mireille" uniqKey="Matrat M" first="Mireille" last="Matrat">Mireille Matrat</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Université Paris Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af5"><addr-line>Faculty of Medicine IFR 10</addr-line>,<institution>University Paris Est-Créteil</institution>,<addr-line>Créteil</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cenee, Sylvie" sort="Cenee, Sylvie" uniqKey="Cenee S" first="Sylvie" last="Cenée">Sylvie Cenée</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Université Paris Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Azizi, Lamiae" sort="Azizi, Lamiae" uniqKey="Azizi L" first="Lamiae" last="Azizi">Lamiae Azizi</name><affiliation wicri:level="1"><nlm:aff id="af6"><institution>University of Sydney, Sydney School of Public Health, Screening an Evaluation Test Program</institution>,<addr-line>Sydney, New South Wales</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Menvielle, Gwenn" sort="Menvielle, Gwenn" uniqKey="Menvielle G" first="Gwenn" last="Menvielle">Gwenn Menvielle</name><affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Department of social epidemiology</addr-line>,<institution>INSERM, UMR_S 1136, Pierre Louis Institute of Epidemiology and Public Health</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Department of social epidemiology</addr-line>,<institution>Sorbonne University, UPMC University of Paris 06, UMR_S 1136, Pierre Louis Institute of Epidemiology and Public Health</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sanchez, Marie" sort="Sanchez, Marie" uniqKey="Sanchez M" first="Marie" last="Sanchez">Marie Sanchez</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Université Paris Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pilorget, Corinne" sort="Pilorget, Corinne" uniqKey="Pilorget C" first="Corinne" last="Pilorget">Corinne Pilorget</name><affiliation wicri:level="1"><nlm:aff id="af9"><institution>French Institute for Public Health Surveillance</institution>,<addr-line>Saint-Maurice</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af10"><addr-line>Epidemiological research and surveillance unit in transport, occupation and environment</addr-line>,<institution>Claude Bernard Lyon1 University</institution>,<addr-line>Lyon</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lapotre Ledoux, Benedicte" sort="Lapotre Ledoux, Benedicte" uniqKey="Lapotre Ledoux B" first="Bénédicte" last="Lapôtre-Ledoux">Bénédicte Lapôtre-Ledoux</name><affiliation wicri:level="1"><nlm:aff id="af11"><institution>Somme Cancer Registry</institution>,<addr-line>Amiens</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Luce, Daniele" sort="Luce, Daniele" uniqKey="Luce D" first="Danièle" last="Luce">Danièle Luce</name><affiliation wicri:level="1"><nlm:aff id="af12"><institution>INSERM, U 1085_IRSET</institution>,<addr-line>Pointe-à-Pitre</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>University of Rennes 1</institution>,<addr-line>Rennes</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Richardson, Sylvia" sort="Richardson, Sylvia" uniqKey="Richardson S" first="Sylvia" last="Richardson">Sylvia Richardson</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>MRC Biostatistics Unit</addr-line>,<institution>Cambridge Institute of Public Health, Cambridge Biomedical Campus</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stucker, Isabelle" sort="Stucker, Isabelle" uniqKey="Stucker I" first="Isabelle" last="Stücker">Isabelle Stücker</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Université Paris Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Occupational and Environmental Medicine</title><idno type="ISSN">1351-0711</idno><idno type="eISSN">1470-7926</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The association between lung cancer and occupational exposure to organic solvents is discussed. Since different solvents are often used <italic>simultaneously</italic>, it is difficult to assess the role of individual substances.</p></sec><sec><title>Objectives</title><p>The present study is focused on an in-depth investigation of the potential association between lung cancer risk and occupational exposure to a large group of organic solvents, taking into account the well-known risk factors for lung cancer, tobacco smoking and occupational exposure to asbestos.</p></sec><sec><title>Methods</title><p>We analysed data from the Investigation of occupational and environmental causes of respiratory cancers (ICARE) study, a large French population-based case–control study, set up between 2001 and 2007. A total of 2276 male cases and 2780 male controls were interviewed, and long-life occupational history was collected. In order to overcome the analytical difficulties created by multiple correlated exposures, we carried out a novel type of analysis based on Bayesian profile regression.</p></sec><sec><title>Results</title><p>After analysis with conventional logistic regression methods, none of the 11 solvents examined were associated with lung cancer risk. Through a profile regression approach, we did not observe any significant association between solvent exposure and lung cancer. However, we identified clusters at high risk that are related to occupations known to be at risk of developing lung cancer, such as painters.</p></sec><sec><title>Conclusions</title><p>Organic solvents do not appear to be substantial contributors to the occupational risk of lung cancer for the occupations known to be at risk.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Binder Foucard, F" uniqKey="Binder Foucard F">F Binder-Foucard</name></author><author><name sortKey="Belot, A" uniqKey="Belot A">A Belot</name></author><author><name sortKey="Delafosse, P" uniqKey="Delafosse P">P Delafosse</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Imbernon, E" uniqKey="Imbernon E">E Imbernon</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Hayes, Rb" uniqKey="Hayes R">RB 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Occup Environ Med</journal-id><journal-id journal-id-type="iso-abbrev">Occup Environ Med</journal-id><journal-id journal-id-type="hwp">oemed</journal-id><journal-id journal-id-type="publisher-id">oem</journal-id><journal-title-group><journal-title>Occupational and Environmental Medicine</journal-title></journal-title-group><issn pub-type="ppub">1351-0711</issn><issn pub-type="epub">1470-7926</issn><publisher><publisher-name>BMJ Publishing Group</publisher-name><publisher-loc>BMA House, Tavistock Square, London, WC1H 9JR</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26911986</article-id><article-id pub-id-type="pmc">4893113</article-id><article-id pub-id-type="publisher-id">oemed-2015-103177</article-id><article-id pub-id-type="doi">10.1136/oemed-2015-103177</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>1506</subject></subj-group><subj-group subj-group-type="heading"><subject>Workplace</subject></subj-group><series-title>Original article</series-title></article-categories><title-group><article-title>Multidimensional analysis of the effect of occupational exposure to organic solvents on lung cancer risk: the ICARE study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Mattei</surname><given-names>Francesca</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Liverani</surname><given-names>Silvia</given-names></name><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Guida</surname><given-names>Florence</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Matrat</surname><given-names>Mireille</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Cenée</surname><given-names>Sylvie</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Azizi</surname><given-names>Lamiae</given-names></name><xref ref-type="aff" rid="af6">6</xref></contrib><contrib contrib-type="author"><name><surname>Menvielle</surname><given-names>Gwenn</given-names></name><xref ref-type="aff" rid="af7">7</xref><xref ref-type="aff" rid="af8">8</xref></contrib><contrib contrib-type="author"><name><surname>Sanchez</surname><given-names>Marie</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Pilorget</surname><given-names>Corinne</given-names></name><xref ref-type="aff" rid="af9">9</xref><xref ref-type="aff" rid="af10">10</xref></contrib><contrib contrib-type="author"><name><surname>Lapôtre-Ledoux</surname><given-names>Bénédicte</given-names></name><xref ref-type="aff" rid="af11">11</xref></contrib><contrib contrib-type="author"><name><surname>Luce</surname><given-names>Danièle</given-names></name><xref ref-type="aff" rid="af12">12</xref><xref ref-type="aff" rid="af13">13</xref></contrib><contrib contrib-type="author"><name><surname>Richardson</surname><given-names>Sylvia</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Stücker</surname><given-names>Isabelle</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><collab>ICARE Study Group</collab></contrib></contrib-group><contrib-group><contrib contrib-type="collab"><name><surname>Guizard</surname><given-names>Anne-Valérie</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Danzon</surname><given-names>Arlette</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Woronoff</surname><given-names>Anne-Sophie</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Michel</surname><given-names>Velten</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Buemi</surname><given-names>Antoine</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Marrer</surname><given-names>Émilie</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Tretarre</surname><given-names>Brigitte</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Colonna</surname><given-names>Marc</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Delafosse</surname><given-names>Patricia</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Bercelli</surname><given-names>Paolo</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Bara</surname><given-names>Simona</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Raverdy</surname><given-names>Nicole</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Gaye</surname><given-names>Oumar</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Lamkarkach</surname><given-names>Farida</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Guida</surname><given-names>Florence</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Carton</surname><given-names>Matthieu</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Cyr</surname><given-names>Diane</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Menvielle</surname><given-names>Gwen</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Paget-Bailly</surname><given-names>Sophie</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Radoï</surname><given-names>Loredana</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Schamus</surname><given-names>Annie</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Papadopoulos</surname><given-names>Alexandra</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Stücker</surname><given-names>Isabelle</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Fevotte</surname><given-names>Joëlle</given-names></name></contrib></contrib-group><aff id="af1"><label>1</label><institution>Université Paris Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></aff><aff id="af2"><label>2</label><addr-line>Department of Mathematics</addr-line>,<institution>Brunel University London</institution>,<addr-line>Uxbridge</addr-line>,<country>UK</country></aff><aff id="af3"><label>3</label><addr-line>MRC Biostatistics Unit</addr-line>,<institution>Cambridge Institute of Public Health, Cambridge Biomedical Campus</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></aff><aff id="af4"><label>4</label><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Imperial College London, MRC-PHE Centre for Environment and Health, School of Public Health</institution>,<addr-line>London</addr-line>,<country>UK</country></aff><aff id="af5"><label>5</label><addr-line>Faculty of Medicine IFR 10</addr-line>,<institution>University Paris Est-Créteil</institution>,<addr-line>Créteil</addr-line>,<country>France</country></aff><aff id="af6"><label>6</label><institution>University of Sydney, Sydney School of Public Health, Screening an Evaluation Test Program</institution>,<addr-line>Sydney, New South Wales</addr-line>,<country>Australia</country></aff><aff id="af7"><label>7</label><addr-line>Department of social epidemiology</addr-line>,<institution>INSERM, UMR_S 1136, Pierre Louis Institute of Epidemiology and Public Health</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></aff><aff id="af8"><label>8</label><addr-line>Department of social epidemiology</addr-line>,<institution>Sorbonne University, UPMC University of Paris 06, UMR_S 1136, Pierre Louis Institute of Epidemiology and Public Health</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></aff><aff id="af9"><label>9</label><institution>French Institute for Public Health Surveillance</institution>,<addr-line>Saint-Maurice</addr-line>,<country>France</country></aff><aff id="af10"><label>10</label><addr-line>Epidemiological research and surveillance unit in transport, occupation and environment</addr-line>,<institution>Claude Bernard Lyon1 University</institution>,<addr-line>Lyon</addr-line>,<country>France</country></aff><aff id="af11"><label>11</label><institution>Somme Cancer Registry</institution>,<addr-line>Amiens</addr-line>,<country>France</country></aff><aff id="af12"><label>12</label><institution>INSERM, U 1085_IRSET</institution>,<addr-line>Pointe-à-Pitre</addr-line>,<country>France</country></aff><aff id="af13"><label>13</label><institution>University of Rennes 1</institution>,<addr-line>Rennes</addr-line>,<country>France</country></aff><author-notes><corresp><label>Correspondence to</label> Francesca Mattei, CESP Centre for Research in Epidemiology and Population Health, 16 avenue Paul Vaillant Couturier, Villejuif Cedex 94807, France; <email>francesca.mattei@inserm.fr</email></corresp><fn><p>SR and IS equally contributed.</p></fn></author-notes><pub-date pub-type="ppub"><month>6</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>24</day><month>2</month><year>2016</year></pub-date><volume>73</volume><issue>6</issue><fpage>368</fpage><lpage>377</lpage><history><date date-type="received"><day>9</day><month>7</month><year>2015</year></date><date date-type="rev-recd"><day>22</day><month>1</month><year>2016</year></date><date date-type="accepted"><day>5</day><month>2</month><year>2016</year></date></history><permissions><copyright-statement>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/</copyright-statement><copyright-year>2016</copyright-year><license license-type="open-access"><license-p>This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link></license-p></license></permissions><self-uri xlink:title="pdf" xlink:href="oemed-2015-103177.pdf"></self-uri><abstract><sec><title>Background</title><p>The association between lung cancer and occupational exposure to organic solvents is discussed. Since different solvents are often used <italic>simultaneously</italic>, it is difficult to assess the role of individual substances.</p></sec><sec><title>Objectives</title><p>The present study is focused on an in-depth investigation of the potential association between lung cancer risk and occupational exposure to a large group of organic solvents, taking into account the well-known risk factors for lung cancer, tobacco smoking and occupational exposure to asbestos.</p></sec><sec><title>Methods</title><p>We analysed data from the Investigation of occupational and environmental causes of respiratory cancers (ICARE) study, a large French population-based case–control study, set up between 2001 and 2007. A total of 2276 male cases and 2780 male controls were interviewed, and long-life occupational history was collected. In order to overcome the analytical difficulties created by multiple correlated exposures, we carried out a novel type of analysis based on Bayesian profile regression.</p></sec><sec><title>Results</title><p>After analysis with conventional logistic regression methods, none of the 11 solvents examined were associated with lung cancer risk. Through a profile regression approach, we did not observe any significant association between solvent exposure and lung cancer. However, we identified clusters at high risk that are related to occupations known to be at risk of developing lung cancer, such as painters.</p></sec><sec><title>Conclusions</title><p>Organic solvents do not appear to be substantial contributors to the occupational risk of lung cancer for the occupations known to be at risk.</p></sec></abstract><kwd-group><kwd>Occupational exposure</kwd><kwd>Organic solvents</kwd><kwd>Lung cancer</kwd><kwd>Bayesian profile regression</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>special-feature</meta-name><meta-value>unlocked</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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