Endometriosis: a high-risk population for major chronic diseases?
Identifieur interne : 000393 ( Pmc/Curation ); précédent : 000392; suivant : 000394Endometriosis: a high-risk population for major chronic diseases?
Auteurs : Marina Kvaskoff [États-Unis, France, Australie] ; Fan Mu [États-Unis] ; Kathryn L. Terry [États-Unis] ; Holly R. Harris [États-Unis, Suède] ; Elizabeth M. Poole [États-Unis] ; Leslie Farland [États-Unis] ; Stacey A. Missmer [États-Unis]Source :
- Human Reproduction Update [ 1355-4786 ] ; 2015.
Abstract
Despite an estimated prevalence of 10% in women, the etiology of endometriosis remains poorly understood. Over recent decades, endometriosis has been associated with risk of several chronic diseases, such as cancer, autoimmune diseases, asthma/atopic diseases and cardiovascular diseases. A deeper understanding of these associations is needed as they may provide new leads into the causes or consequences of endometriosis. This review summarizes the available epidemiological findings on the associations between endometriosis and other chronic diseases and discusses hypotheses for underlying mechanisms, potential sources of bias and methodological complexities.
We performed a comprehensive search of the PubMed/Medline and ISI Web of Knowledge databases for all studies reporting on the associations between endometriosis and other diseases published in English through to May 2014, using numerous search terms. We additionally examined the reference lists of all identified papers to capture any additional articles that were not identified through computer searches.
We identified 21 studies on the associations between endometriosis and ovarian cancer, 14 for breast cancer, 8 for endometrial cancer, 4 for cervical cancer, 12 for cutaneous melanoma and 3 for non-Hodgkin's lymphoma, as well as 9 on the links between endometriosis and autoimmune diseases, 6 on the links with asthma and atopic diseases, and 4 on the links with cardiovascular diseases. Endometriosis patients were reported to be at higher risk of ovarian and breast cancers, cutaneous melanoma, asthma, and some autoimmune, cardiovascular and atopic diseases, and at decreased risk of cervical cancer.
Increasing evidence suggests that endometriosis patients are at higher risk of several chronic diseases. Although the underlying mechanisms are not yet understood, the available data to date suggest that endometriosis is not harmless with respects to women's long-term health. If these relationships are confirmed, these findings may have important implications in screening practices and in the management and care of endometriosis patients.
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DOI: 10.1093/humupd/dmv013
PubMed: 25765863
PubMed Central: 4463000
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Poole</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Channing Division of Network Medicine, Department of Medicine</addr-line>,<institution>Brigham & Women's Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Farland, Leslie" sort="Farland, Leslie" uniqKey="Farland L" first="Leslie" last="Farland">Leslie Farland</name><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Epidemiology</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Missmer, Stacey A" sort="Missmer, Stacey A" uniqKey="Missmer S" first="Stacey A." last="Missmer">Stacey A. 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Paris Sud 11</institution>,<addr-line>UMRS 1018, F-94807 Villejuif</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Gustave Roussy</institution>,<addr-line>F-94805 Villejuif</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af5"><addr-line>Cancer Control Group</addr-line>,<institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Herston, QLD 4006</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mu, Fan" sort="Mu, Fan" uniqKey="Mu F" first="Fan" last="Mu">Fan Mu</name><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Epidemiology</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Terry, Kathryn L" sort="Terry, Kathryn L" uniqKey="Terry K" first="Kathryn L." last="Terry">Kathryn L. Terry</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Channing Division of Network Medicine, Department of Medicine</addr-line>,<institution>Brigham & Women's Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Epidemiology</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Department of Obstetrics, Gynecology, and Reproductive Biology</addr-line>,<institution>Brigham and Women's Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Holly R" sort="Harris, Holly R" uniqKey="Harris H" first="Holly R." last="Harris">Holly R. Harris</name><affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Department of Obstetrics, Gynecology, and Reproductive Biology</addr-line>,<institution>Brigham and Women's Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Division of Nutritional</addr-line><addr-line>Epidemiology</addr-line>,<institution>The National Institute for Environmental Medicine, Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Poole, Elizabeth M" sort="Poole, Elizabeth M" uniqKey="Poole E" first="Elizabeth M." last="Poole">Elizabeth M. Poole</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Channing Division of Network Medicine, Department of Medicine</addr-line>,<institution>Brigham & Women's Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Farland, Leslie" sort="Farland, Leslie" uniqKey="Farland L" first="Leslie" last="Farland">Leslie Farland</name><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Epidemiology</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Missmer, Stacey A" sort="Missmer, Stacey A" uniqKey="Missmer S" first="Stacey A." last="Missmer">Stacey A. Missmer</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Channing Division of Network Medicine, Department of Medicine</addr-line>,<institution>Brigham & Women's Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Epidemiology</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Department of Obstetrics, Gynecology, and Reproductive Biology</addr-line>,<institution>Brigham and Women's Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Human Reproduction Update</title><idno type="ISSN">1355-4786</idno><idno type="eISSN">1460-2369</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>BACKGROUND</title><p>Despite an estimated prevalence of 10% in women, the etiology of endometriosis remains poorly understood. Over recent decades, endometriosis has been associated with risk of several chronic diseases, such as cancer, autoimmune diseases, asthma/atopic diseases and cardiovascular diseases. A deeper understanding of these associations is needed as they may provide new leads into the causes or consequences of endometriosis. This review summarizes the available epidemiological findings on the associations between endometriosis and other chronic diseases and discusses hypotheses for underlying mechanisms, potential sources of bias and methodological complexities.</p></sec><sec><title>METHODS</title><p>We performed a comprehensive search of the PubMed/Medline and ISI Web of Knowledge databases for all studies reporting on the associations between endometriosis and other diseases published in English through to May 2014, using numerous search terms. We additionally examined the reference lists of all identified papers to capture any additional articles that were not identified through computer searches.</p></sec><sec><title>RESULTS</title><p>We identified 21 studies on the associations between endometriosis and ovarian cancer, 14 for breast cancer, 8 for endometrial cancer, 4 for cervical cancer, 12 for cutaneous melanoma and 3 for non-Hodgkin's lymphoma, as well as 9 on the links between endometriosis and autoimmune diseases, 6 on the links with asthma and atopic diseases, and 4 on the links with cardiovascular diseases. Endometriosis patients were reported to be at higher risk of ovarian and breast cancers, cutaneous melanoma, asthma, and some autoimmune, cardiovascular and atopic diseases, and at decreased risk of cervical cancer.</p></sec><sec><title>CONCLUSIONS</title><p>Increasing evidence suggests that endometriosis patients are at higher risk of several chronic diseases. Although the underlying mechanisms are not yet understood, the available data to date suggest that endometriosis is not harmless with respects to women's long-term health. If these relationships are confirmed, these findings may have important implications in screening practices and in the management and care of endometriosis patients.</p></sec></div></front></TEI><pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Hum Reprod Update</journal-id><journal-id journal-id-type="iso-abbrev">Hum. Reprod. Update</journal-id><journal-id journal-id-type="publisher-id">humupd</journal-id><journal-id journal-id-type="hwp">humupd</journal-id><journal-title-group><journal-title>Human Reproduction Update</journal-title></journal-title-group><issn pub-type="ppub">1355-4786</issn><issn pub-type="epub">1460-2369</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25765863</article-id><article-id pub-id-type="pmc">4463000</article-id><article-id pub-id-type="doi">10.1093/humupd/dmv013</article-id><article-id pub-id-type="publisher-id">dmv013</article-id><article-categories><subj-group subj-group-type="heading"><subject>Reviews</subject></subj-group></article-categories><title-group><article-title>Endometriosis: a high-risk population for major chronic diseases?</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kvaskoff</surname><given-names>Marina</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af3">3</xref><xref ref-type="aff" rid="af4">4</xref><xref ref-type="aff" rid="af5">5</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Mu</surname><given-names>Fan</given-names></name><xref ref-type="aff" rid="af6">6</xref></contrib><contrib contrib-type="author"><name><surname>Terry</surname><given-names>Kathryn L.</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af6">6</xref><xref ref-type="aff" rid="af7">7</xref></contrib><contrib contrib-type="author"><name><surname>Harris</surname><given-names>Holly R.</given-names></name><xref ref-type="aff" rid="af7">7</xref><xref ref-type="aff" rid="af8">8</xref></contrib><contrib contrib-type="author"><name><surname>Poole</surname><given-names>Elizabeth M.</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Farland</surname><given-names>Leslie</given-names></name><xref ref-type="aff" rid="af6">6</xref></contrib><contrib contrib-type="author"><name><surname>Missmer</surname><given-names>Stacey A.</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af6">6</xref><xref ref-type="aff" rid="af7">7</xref></contrib><aff id="af1"><label>1</label><addr-line>Channing Division of Network Medicine, Department of Medicine</addr-line>,<institution>Brigham & Women's Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country></aff><aff id="af2"><label>2</label><addr-line>Inserm U1018, Centre for Research in Epidemiology and Population Health (CESP)</addr-line>,<institution>‘Nutrition, Hormones and Women's Health’ Team</institution>,<addr-line>F-94805 Villejuif</addr-line>,<country>France</country></aff><aff id="af3"><label>3</label><institution>Univ. Paris Sud 11</institution>,<addr-line>UMRS 1018, F-94807 Villejuif</addr-line>,<country>France</country></aff><aff id="af4"><label>4</label><institution>Gustave Roussy</institution>,<addr-line>F-94805 Villejuif</addr-line>,<country>France</country></aff><aff id="af5"><label>5</label><addr-line>Cancer Control Group</addr-line>,<institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Herston, QLD 4006</addr-line>,<country>Australia</country></aff><aff id="af6"><label>6</label><addr-line>Department of Epidemiology</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country></aff><aff id="af7"><label>7</label><addr-line>Department of Obstetrics, Gynecology, and Reproductive Biology</addr-line>,<institution>Brigham and Women's Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country></aff><aff id="af8"><label>8</label><addr-line>Division of Nutritional</addr-line><addr-line>Epidemiology</addr-line>,<institution>The National Institute for Environmental Medicine, Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country></aff></contrib-group><author-notes><corresp id="cor1"><label>*</label>Correspondence address. Channing Division of Network Medicine, 181 Longwood Avenue, Boston, MA 02115, USA. Tel: +<phone>1-617-525-2263</phone>; Fax: +<fax>1-617-525-2008</fax>; E-mail: <email>marina.kvaskoff@channing.harvard.edu</email></corresp></author-notes><pub-date pub-type="ppub"><month>7</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>11</day><month>3</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>7</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 12 months and
0 days and was based on the
<volume>21</volume><issue>4</issue><fpage>500</fpage><lpage>516</lpage><history><date date-type="received"><day>27</day><month>11</month><year>2014</year></date><date date-type="rev-recd"><day>12</day><month>2</month><year>2015</year></date><date date-type="accepted"><day>20</day><month>2</month><year>2015</year></date></history><permissions><copyright-statement>© The Author 2015. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com</copyright-statement><copyright-year>2015</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="dmv013.pdf"></self-uri><abstract><sec><title>BACKGROUND</title><p>Despite an estimated prevalence of 10% in women, the etiology of endometriosis remains poorly understood. Over recent decades, endometriosis has been associated with risk of several chronic diseases, such as cancer, autoimmune diseases, asthma/atopic diseases and cardiovascular diseases. A deeper understanding of these associations is needed as they may provide new leads into the causes or consequences of endometriosis. This review summarizes the available epidemiological findings on the associations between endometriosis and other chronic diseases and discusses hypotheses for underlying mechanisms, potential sources of bias and methodological complexities.</p></sec><sec><title>METHODS</title><p>We performed a comprehensive search of the PubMed/Medline and ISI Web of Knowledge databases for all studies reporting on the associations between endometriosis and other diseases published in English through to May 2014, using numerous search terms. We additionally examined the reference lists of all identified papers to capture any additional articles that were not identified through computer searches.</p></sec><sec><title>RESULTS</title><p>We identified 21 studies on the associations between endometriosis and ovarian cancer, 14 for breast cancer, 8 for endometrial cancer, 4 for cervical cancer, 12 for cutaneous melanoma and 3 for non-Hodgkin's lymphoma, as well as 9 on the links between endometriosis and autoimmune diseases, 6 on the links with asthma and atopic diseases, and 4 on the links with cardiovascular diseases. Endometriosis patients were reported to be at higher risk of ovarian and breast cancers, cutaneous melanoma, asthma, and some autoimmune, cardiovascular and atopic diseases, and at decreased risk of cervical cancer.</p></sec><sec><title>CONCLUSIONS</title><p>Increasing evidence suggests that endometriosis patients are at higher risk of several chronic diseases. Although the underlying mechanisms are not yet understood, the available data to date suggest that endometriosis is not harmless with respects to women's long-term health. If these relationships are confirmed, these findings may have important implications in screening practices and in the management and care of endometriosis patients.</p></sec></abstract><kwd-group><kwd>asthma</kwd><kwd>autoimmune diseases</kwd><kwd>cancer</kwd><kwd>cardiovascular diseases</kwd><kwd>endometriosis</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>cover-date</meta-name><meta-value>July/August 2015</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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