Population susceptibility to a variant swine-origin influenza virus A(H3N2) in Vietnam, 2011–2012
Identifieur interne : 000157 ( Pmc/Curation ); précédent : 000156; suivant : 000158Population susceptibility to a variant swine-origin influenza virus A(H3N2) in Vietnam, 2011–2012
Auteurs : L. N. M. Hoa [Viêt Nam] ; J. E. Bryant [Viêt Nam, Royaume-Uni] ; M. Choisy [Viêt Nam, France] ; L. A. Nguyet [Viêt Nam] ; N. T. Bao [Viêt Nam] ; N. H. Trang [Viêt Nam] ; N. T. K. Chuc [Viêt Nam] ; T. K. Toan [Viêt Nam] ; T. Saito [Japon] ; N. Takemae [Japon] ; P. Horby [Viêt Nam, Royaume-Uni] ; H. Wertheim [Viêt Nam, Royaume-Uni] ; A. Fox [Viêt Nam, Australie]Source :
- Epidemiology and Infection [ 0950-2688 ] ; 2015.
Abstract
A reassortant swine-origin A(H3N2) virus (A/swine/BinhDuong/03-9/2010) was detected through swine surveillance programmes in southern Vietnam in 2010. This virus contains haemagglutinin and neuraminidase genes from a human A(H3N2) virus circulating around 2004–2006, and the internal genes from triple-reassortant swine influenza A viruses (IAVs). To assess population susceptibility to this virus we measured haemagglutination inhibiting (HI) titres to A/swine/BinhDuong/03-9/2010 and to seasonal A/Perth/16/2009 for 947 sera collected from urban and rural Vietnamese people during 2011–2012. Seroprevalence (HI ⩾ 40) was high and similar for both viruses, with 62·6% [95% confidence interval (CI) 59·4–65·7] against A/Perth/16/2009 and 54·6% (95% CI 51·4–57·8%) against A/swine/BinhDuong/03-9/2010, and no significant differences between urban and rural participants. Children aged <5 years lacked antibodies to the swine origin H3 virus despite high seroprevalence for A/Perth/16/2009. These results reveal vulnerability to infection to this contemporary swine IAV in children aged <5 years; however, cross-reactive immunity in adults would likely limit epidemic emergence potential.
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DOI: 10.1017/S0950268815000187
PubMed: 25761949
PubMed Central: 4595856
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in Vietnam, 2011–2012</title><author><name sortKey="Hoa, L N M" sort="Hoa, L N M" uniqKey="Hoa L" first="L. N. M." last="Hoa">L. N. M. Hoa</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme</institution>,<country>Vietnam</country></nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bryant, J E" sort="Bryant, J E" uniqKey="Bryant J" first="J. E." last="Bryant">J. E. Bryant</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme</institution>,<country>Vietnam</country></nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Nuffield Department of Medicine</addr-line>,<institution>Oxford University</institution>,<addr-line>Oxford</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Choisy, M" sort="Choisy, M" uniqKey="Choisy M" first="M." last="Choisy">M. Choisy</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme</institution>,<country>Vietnam</country></nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>MIVEGEC</institution> (<addr-line>UMR Universités Montpellier 1 & 2</addr-line>,<addr-line>CNRS 5290</addr-line>,<addr-line>IRD 224</addr-line>),<addr-line>Montpellier</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nguyet, L A" sort="Nguyet, L A" uniqKey="Nguyet L" first="L. A." last="Nguyet">L. A. Nguyet</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme</institution>,<country>Vietnam</country></nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bao, N T" sort="Bao, N T" uniqKey="Bao N" first="N. T." last="Bao">N. T. Bao</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme</institution>,<country>Vietnam</country></nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Trang, N H" sort="Trang, N H" uniqKey="Trang N" first="N. H." last="Trang">N. H. Trang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme</institution>,<country>Vietnam</country></nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chuc, N T K" sort="Chuc, N T K" uniqKey="Chuc N" first="N. T. K." last="Chuc">N. T. K. Chuc</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Hanoi Medical University</institution>,<addr-line>Hanoi</addr-line>,<country>Vietnam</country></nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Toan, T K" sort="Toan, T K" uniqKey="Toan T" first="T. K." last="Toan">T. K. Toan</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Hanoi Medical University</institution>,<addr-line>Hanoi</addr-line>,<country>Vietnam</country></nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Saito, T" sort="Saito, T" uniqKey="Saito T" first="T." last="Saito">T. Saito</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Influenza and Prion Diseases Research Center</addr-line>,<institution>National Institute of Animal Health</institution>,<addr-line>National Agriculture and Food Research Organization (NARO)</addr-line>,<addr-line>Ibaraki</addr-line>,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Takemae, N" sort="Takemae, N" uniqKey="Takemae N" first="N." last="Takemae">N. Takemae</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Influenza and Prion Diseases Research Center</addr-line>,<institution>National Institute of Animal Health</institution>,<addr-line>National Agriculture and Food Research Organization (NARO)</addr-line>,<addr-line>Ibaraki</addr-line>,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Horby, P" sort="Horby, P" uniqKey="Horby P" first="P." last="Horby">P. Horby</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme</institution>,<country>Vietnam</country></nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Nuffield Department of Medicine</addr-line>,<institution>Oxford University</institution>,<addr-line>Oxford</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wertheim, H" sort="Wertheim, H" uniqKey="Wertheim H" first="H." last="Wertheim">H. Wertheim</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme</institution>,<country>Vietnam</country></nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Nuffield Department of Medicine</addr-line>,<institution>Oxford University</institution>,<addr-line>Oxford</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fox, A" sort="Fox, A" uniqKey="Fox A" first="A." last="Fox">A. Fox</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme</institution>,<country>Vietnam</country></nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>The University of Melbourne</institution>,<addr-line>Peter Doherty Institute for Infection and Immunity</addr-line>,<addr-line>Department of Microbiology and Immunology</addr-line>,<addr-line>Parkville</addr-line>,<addr-line>Victoria</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Epidemiology and Infection</title><idno type="ISSN">0950-2688</idno><idno type="eISSN">1469-4409</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>SUMMARY</title><p>A reassortant swine-origin A(H3N2) virus (A/swine/BinhDuong/03-9/2010) was detected
through swine surveillance programmes in southern Vietnam in 2010. This virus contains
haemagglutinin and neuraminidase genes from a human A(H3N2) virus circulating around
2004–2006, and the internal genes from triple-reassortant swine influenza A viruses
(IAVs). To assess population susceptibility to this virus we measured haemagglutination
inhibiting (HI) titres to A/swine/BinhDuong/03-9/2010 and to seasonal A/Perth/16/2009 for
947 sera collected from urban and rural Vietnamese people during 2011–2012. Seroprevalence
(HI ⩾ 40) was high and similar for both viruses, with 62·6% [95% confidence interval (CI)
59·4–65·7] against A/Perth/16/2009 and 54·6% (95% CI 51·4–57·8%) against
A/swine/BinhDuong/03-9/2010, and no significant differences between urban and rural
participants. Children aged <5 years lacked antibodies to the swine origin H3 virus
despite high seroprevalence for A/Perth/16/2009. These results reveal vulnerability to
infection to this contemporary swine IAV in children aged <5 years; however,
cross-reactive immunity in adults would likely limit epidemic emergence potential.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Nelson, Mi" uniqKey="Nelson M">MI Nelson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vijaykrishna, D" uniqKey="Vijaykrishna D">D Vijaykrishna</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Campitelli, L" uniqKey="Campitelli L">L Campitelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harder, Tc" uniqKey="Harder T">TC Harder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ngo, Lt" uniqKey="Ngo L">LT Ngo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dao, Tt" uniqKey="Dao T">TT Dao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Houser, Kv" uniqKey="Houser K">KV Houser</name></author><author><name sortKey="Katz, Jm" uniqKey="Katz J">JM Katz</name></author><author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skowronski, Dm" uniqKey="Skowronski D">DM Skowronski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lessler, J" uniqKey="Lessler J">J Lessler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fonville, Jm" uniqKey="Fonville J">JM Fonville</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="brief-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Epidemiol Infect</journal-id><journal-id journal-id-type="iso-abbrev">Epidemiol. Infect</journal-id><journal-id journal-id-type="publisher-id">HYG</journal-id><journal-title-group><journal-title>Epidemiology and Infection</journal-title></journal-title-group><issn pub-type="ppub">0950-2688</issn><issn pub-type="epub">1469-4409</issn><publisher><publisher-name>Cambridge University Press</publisher-name><publisher-loc>Cambridge, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25761949</article-id><article-id pub-id-type="pmc">4595856</article-id><article-id pub-id-type="doi">10.1017/S0950268815000187</article-id><article-id pub-id-type="pii">S0950268815000187</article-id><article-id pub-id-type="publisher-id">00018</article-id><article-categories><subj-group subj-group-type="heading"><subject>Short Report</subject></subj-group><subj-group subj-group-type="section"><subject>Influenza</subject></subj-group></article-categories><title-group><article-title>Population susceptibility to a variant swine-origin influenza virus A(H3N2)
in Vietnam, 2011–2012</article-title><alt-title alt-title-type="left-running">L. N. M. Hoa and others</alt-title><alt-title alt-title-type="right-running">Human susceptibility to swine influenza in
Vietnam</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>HOA</surname><given-names>L. N. M.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>BRYANT</surname><given-names>J. E.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>CHOISY</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>NGUYET</surname><given-names>L. A.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>BAO</surname><given-names>N. T.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>TRANG</surname><given-names>N. H.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>CHUC</surname><given-names>N. T. K.</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>TOAN</surname><given-names>T. K.</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>SAITO</surname><given-names>T.</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>TAKEMAE</surname><given-names>N.</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>HORBY</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>WERTHEIM</surname><given-names>H.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>FOX</surname><given-names>A.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff6">6</xref></contrib></contrib-group><aff id="aff1"><label>1</label><institution>Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme</institution>,<country>Vietnam</country></aff><aff id="aff2"><label>2</label><addr-line>Nuffield Department of Medicine</addr-line>,<institution>Oxford University</institution>,<addr-line>Oxford</addr-line>,<country>UK</country></aff><aff id="aff3"><label>3</label><institution>MIVEGEC</institution> (<addr-line>UMR Universités Montpellier 1 & 2</addr-line>,<addr-line>CNRS 5290</addr-line>,<addr-line>IRD 224</addr-line>),<addr-line>Montpellier</addr-line>,<country>France</country></aff><aff id="aff4"><label>4</label><institution>Hanoi Medical University</institution>,<addr-line>Hanoi</addr-line>,<country>Vietnam</country></aff><aff id="aff5"><label>5</label><addr-line>Influenza and Prion Diseases Research Center</addr-line>,<institution>National Institute of Animal Health</institution>,<addr-line>National Agriculture and Food Research Organization (NARO)</addr-line>,<addr-line>Ibaraki</addr-line>,<country>Japan</country></aff><aff id="aff6"><label>6</label><institution>The University of Melbourne</institution>,<addr-line>Peter Doherty Institute for Infection and Immunity</addr-line>,<addr-line>Department of Microbiology and Immunology</addr-line>,<addr-line>Parkville</addr-line>,<addr-line>Victoria</addr-line>,<country>Australia</country></aff><author-notes><corresp id="cor1"><label>*</label><addr-line>Author for correspondence: J. E.
Bryant</addr-line>, <institution>Oxford University Clinical Research Unit
Vietnam</institution>, <addr-line>National Hospital of Tropical Diseases</addr-line>,
<addr-line>78 Giai Phong Street</addr-line>, <addr-line>Dong Da District</addr-line>,
<addr-line>Hanoi</addr-line>, <country>Vietnam</country> (Email: <email>jbryant@oucru.org</email>)</corresp></author-notes><pub-date pub-type="ppub"><month>10</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>12</day><month>3</month><year>2015</year></pub-date><volume>143</volume><issue>14</issue><fpage>2959</fpage><lpage>2964</lpage><history><date date-type="received"><day>15</day><month>8</month><year>2014</year></date><date date-type="rev-recd"><day>16</day><month>1</month><year>2015</year></date><date date-type="accepted"><day>21</day><month>1</month><year>2015</year></date></history><permissions><copyright-statement>© Cambridge University Press 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder>Cambridge University Press</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/3.0/"><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>This is an Open Access article, distributed under the terms of the Creative
Commons Attribution licence (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/3.0/">http://creativecommons.org/licenses/by/3.0/</ext-link>), which permits
unrestricted re-use, distribution, and reproduction in any medium, provided the original
work is properly cited.</license-p></license></permissions><self-uri xlink:title="pdf" xlink:href="S0950268815000187a.pdf"></self-uri><abstract abstract-type="normal"><title>SUMMARY</title><p>A reassortant swine-origin A(H3N2) virus (A/swine/BinhDuong/03-9/2010) was detected
through swine surveillance programmes in southern Vietnam in 2010. This virus contains
haemagglutinin and neuraminidase genes from a human A(H3N2) virus circulating around
2004–2006, and the internal genes from triple-reassortant swine influenza A viruses
(IAVs). To assess population susceptibility to this virus we measured haemagglutination
inhibiting (HI) titres to A/swine/BinhDuong/03-9/2010 and to seasonal A/Perth/16/2009 for
947 sera collected from urban and rural Vietnamese people during 2011–2012. Seroprevalence
(HI ⩾ 40) was high and similar for both viruses, with 62·6% [95% confidence interval (CI)
59·4–65·7] against A/Perth/16/2009 and 54·6% (95% CI 51·4–57·8%) against
A/swine/BinhDuong/03-9/2010, and no significant differences between urban and rural
participants. Children aged <5 years lacked antibodies to the swine origin H3 virus
despite high seroprevalence for A/Perth/16/2009. These results reveal vulnerability to
infection to this contemporary swine IAV in children aged <5 years; however,
cross-reactive immunity in adults would likely limit epidemic emergence potential.</p></abstract><kwd-group><title>Key words</title><kwd>Influenza A</kwd><kwd>virology (human) and epidemiology</kwd><kwd>zoonoses</kwd></kwd-group><counts><fig-count count="2"></fig-count><table-count count="2"></table-count><ref-count count="10"></ref-count><page-count count="6"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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