Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer
Identifieur interne : 000025 ( Pmc/Curation ); précédent : 000024; suivant : 000026Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer
Auteurs : R J E. Skipworth [Royaume-Uni] ; D A C. Deans [Royaume-Uni] ; B H L. Tan [Royaume-Uni] ; K. Sangster [Royaume-Uni] ; S. Paterson-Brown [Royaume-Uni] ; D A Brown [Australie] ; M. Hunter [Australie] ; S N Breit [Australie] ; J A Ross [Royaume-Uni] ; K C H. Fearon [Royaume-Uni]Source :
- British Journal of Cancer [ 0007-0920 ] ; 2010.
Abstract
Macrophage inhibitory cytokine-1(MIC-1) is a potential modulator of systemic inflammation and nutritional depletion, both of which are adverse prognostic factors in oesophago-gastric cancer (OGC).
Plasma MIC-1, systemic inflammation (defined as plasma C-reactive protein (CRP) of ⩾10 mg l–1 or modified Glasgow prognostic score (mGPS) of ⩾1), and nutritional status were assessed in newly diagnosed OGC patients (
MIC-1 was elevated in patients (median=1371 pg ml–1; range 141–39 053) when compared with controls (median=377 pg ml–1; range 141–3786;
There is no independent link between plasma MIC-1 levels and depleted nutritional status or survival in OGC.
Url:
DOI: 10.1038/sj.bjc.6605532
PubMed: 20104227
PubMed Central: 2837566
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000025
Links to Exploration step
PMC:2837566Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer</title><author><name sortKey="Skipworth, R J E" sort="Skipworth, R J E" uniqKey="Skipworth R" first="R J E" last="Skipworth">R J E. Skipworth</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deans, D A C" sort="Deans, D A C" uniqKey="Deans D" first="D A C" last="Deans">D A C. Deans</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tan, B H L" sort="Tan, B H L" uniqKey="Tan B" first="B H L" last="Tan">B H L. Tan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sangster, K" sort="Sangster, K" uniqKey="Sangster K" first="K" last="Sangster">K. Sangster</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Paterson Brown, S" sort="Paterson Brown, S" uniqKey="Paterson Brown S" first="S" last="Paterson-Brown">S. Paterson-Brown</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brown, D A" sort="Brown, D A" uniqKey="Brown D" first="D A" last="Brown">D A Brown</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and University of New South Wales</institution> Victoria Street, Sydney, New South Wales 2010,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hunter, M" sort="Hunter, M" uniqKey="Hunter M" first="M" last="Hunter">M. Hunter</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and University of New South Wales</institution> Victoria Street, Sydney, New South Wales 2010,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Breit, S N" sort="Breit, S N" uniqKey="Breit S" first="S N" last="Breit">S N Breit</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and University of New South Wales</institution> Victoria Street, Sydney, New South Wales 2010,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ross, J A" sort="Ross, J A" uniqKey="Ross J" first="J A" last="Ross">J A Ross</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fearon, K C H" sort="Fearon, K C H" uniqKey="Fearon K" first="K C H" last="Fearon">K C H. Fearon</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20104227</idno><idno type="pmc">2837566</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837566</idno><idno type="RBID">PMC:2837566</idno><idno type="doi">10.1038/sj.bjc.6605532</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000025</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000025</idno><idno type="wicri:Area/Pmc/Curation">000025</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000025</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer</title><author><name sortKey="Skipworth, R J E" sort="Skipworth, R J E" uniqKey="Skipworth R" first="R J E" last="Skipworth">R J E. Skipworth</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deans, D A C" sort="Deans, D A C" uniqKey="Deans D" first="D A C" last="Deans">D A C. Deans</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tan, B H L" sort="Tan, B H L" uniqKey="Tan B" first="B H L" last="Tan">B H L. Tan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sangster, K" sort="Sangster, K" uniqKey="Sangster K" first="K" last="Sangster">K. Sangster</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Paterson Brown, S" sort="Paterson Brown, S" uniqKey="Paterson Brown S" first="S" last="Paterson-Brown">S. Paterson-Brown</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brown, D A" sort="Brown, D A" uniqKey="Brown D" first="D A" last="Brown">D A Brown</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and University of New South Wales</institution> Victoria Street, Sydney, New South Wales 2010,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hunter, M" sort="Hunter, M" uniqKey="Hunter M" first="M" last="Hunter">M. Hunter</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and University of New South Wales</institution> Victoria Street, Sydney, New South Wales 2010,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Breit, S N" sort="Breit, S N" uniqKey="Breit S" first="S N" last="Breit">S N Breit</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and University of New South Wales</institution> Victoria Street, Sydney, New South Wales 2010,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ross, J A" sort="Ross, J A" uniqKey="Ross J" first="J A" last="Ross">J A Ross</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fearon, K C H" sort="Fearon, K C H" uniqKey="Fearon K" first="K C H" last="Fearon">K C H. Fearon</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">British Journal of Cancer</title><idno type="ISSN">0007-0920</idno><idno type="eISSN">1532-1827</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background:</title><p>Macrophage inhibitory cytokine-1(MIC-1) is a potential modulator of systemic inflammation and nutritional depletion, both of which are adverse prognostic factors in oesophago-gastric cancer (OGC).</p></sec><sec><title>Methods:</title><p>Plasma MIC-1, systemic inflammation (defined as plasma C-reactive protein (CRP) of ⩾10 mg l<sup>–1</sup> or modified Glasgow prognostic score (mGPS) of ⩾1), and nutritional status were assessed in newly diagnosed OGC patients (<italic>n</italic>=293). Healthy volunteers (<italic>n</italic>=35) served as controls.</p></sec><sec><title>Results:</title><p>MIC-1 was elevated in patients (median=1371 pg ml<sup>–1</sup>; range 141–39 053) when compared with controls (median=377 pg ml<sup>–1</sup>; range 141–3786; <italic>P</italic><0.001). Patients with gastric tumours (median=1592 pg ml<sup>–1</sup>; range 141–12 643) showed higher MIC-1 concentrations than patients with junctional (median=1337 pg ml<sup>–1</sup>; range 383–39 053) and oesophageal tumours (median=1180 pg ml<sup>–1</sup>; range 258–31 184; <italic>P</italic>=0.015). Patients showed a median weight loss of 6.4% (range 0.0–33.4%), and 42% of patients had an mGPS of ⩾1 or plasma CRP of ⩾10 mg l<sup>–1</sup> (median=9 mg l<sup>–1</sup>; range 1–200). MIC-1 correlated positively with disease stage (<italic>r</italic><sup>2</sup>=0.217; <italic>P</italic><0.001), age (<italic>r</italic><sup>2</sup>=0.332; <italic>P</italic><0.001), CRP (<italic>r</italic><sup>2</sup>=0.314; <italic>P</italic><0.001), and mGPS (<italic>r</italic><sup>2</sup>=0.336; <italic>P</italic><0.001), and negatively with Karnofsky Performance Score (<italic>r</italic><sup>2</sup>=−0.269; <italic>P</italic><0.001). However, although MIC-1 correlated weakly with dietary intake (r<sup>2</sup>=0.157; <italic>P</italic>=0.031), it did not correlate with weight loss, BMI, or anthropometry. Patients with MIC-1 levels in the upper quartile showed reduced survival (median=204 days; 95% CI 157–251) when compared with patients with MIC-1 levels in the lower three quartiles (median=316 days; 95% CI 259–373; <italic>P</italic>=0.036), but MIC-1 was not an independent prognostic indicator.</p></sec><sec><title>Conclusions:</title><p>There is no independent link between plasma MIC-1 levels and depleted nutritional status or survival in OGC.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="other"><pmc-dir>properties open_access</pmc-dir>
<pmc-comment> Original-type: cy</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Cancer</journal-id><journal-title>British Journal of Cancer</journal-title><issn pub-type="ppub">0007-0920</issn><issn pub-type="epub">1532-1827</issn><publisher><publisher-name>Nature Publishing Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20104227</article-id><article-id pub-id-type="pmc">2837566</article-id><article-id pub-id-type="pii">6605532</article-id><article-id pub-id-type="doi">10.1038/sj.bjc.6605532</article-id><article-categories><subj-group subj-group-type="heading"><subject>Clinical Studies</subject></subj-group></article-categories><title-group><article-title>Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Skipworth</surname><given-names>R J E</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Deans</surname><given-names>D A C</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Tan</surname><given-names>B H L</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Sangster</surname><given-names>K</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Paterson-Brown</surname><given-names>S</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Brown</surname><given-names>D A</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Hunter</surname><given-names>M</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Breit</surname><given-names>S N</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Ross</surname><given-names>J A</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Fearon</surname><given-names>K C H</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="corresp" rid="caf1">*</xref></contrib></contrib-group><aff id="aff1"><label>1</label><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></aff><aff id="aff2"><label>2</label><institution>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and University of New South Wales</institution> Victoria Street, Sydney, New South Wales 2010,<country>Australia</country></aff><author-notes><corresp id="caf1"><label>*</label>Author for correspondence: <email xlink:href="mailto:k.fearon@ed.ac.uk">k.fearon@ed.ac.uk</email></corresp></author-notes><pub-date pub-type="epub"><day>26</day><month>01</month><year>2010</year></pub-date><pub-date pub-type="collection"><day>16</day><month>02</month><year>2010</year></pub-date><pub-date pub-type="ppub"><day>16</day><month>02</month><year>2010</year></pub-date><volume>102</volume><issue>4</issue><fpage>665</fpage><lpage>672</lpage><history><date date-type="rev-recd"><day>19</day><month>11</month><year>2009</year></date><date date-type="accepted"><day>02</day><month>12</month><year>2009</year></date></history><copyright-statement>Copyright 2010, Cancer Research UK</copyright-statement><copyright-year>2010</copyright-year><permissions><copyright-holder>Cancer Research UK</copyright-holder></permissions><abstract><sec><title>Background:</title><p>Macrophage inhibitory cytokine-1(MIC-1) is a potential modulator of systemic inflammation and nutritional depletion, both of which are adverse prognostic factors in oesophago-gastric cancer (OGC).</p></sec><sec><title>Methods:</title><p>Plasma MIC-1, systemic inflammation (defined as plasma C-reactive protein (CRP) of ⩾10 mg l<sup>–1</sup> or modified Glasgow prognostic score (mGPS) of ⩾1), and nutritional status were assessed in newly diagnosed OGC patients (<italic>n</italic>=293). Healthy volunteers (<italic>n</italic>=35) served as controls.</p></sec><sec><title>Results:</title><p>MIC-1 was elevated in patients (median=1371 pg ml<sup>–1</sup>; range 141–39 053) when compared with controls (median=377 pg ml<sup>–1</sup>; range 141–3786; <italic>P</italic><0.001). Patients with gastric tumours (median=1592 pg ml<sup>–1</sup>; range 141–12 643) showed higher MIC-1 concentrations than patients with junctional (median=1337 pg ml<sup>–1</sup>; range 383–39 053) and oesophageal tumours (median=1180 pg ml<sup>–1</sup>; range 258–31 184; <italic>P</italic>=0.015). Patients showed a median weight loss of 6.4% (range 0.0–33.4%), and 42% of patients had an mGPS of ⩾1 or plasma CRP of ⩾10 mg l<sup>–1</sup> (median=9 mg l<sup>–1</sup>; range 1–200). MIC-1 correlated positively with disease stage (<italic>r</italic><sup>2</sup>=0.217; <italic>P</italic><0.001), age (<italic>r</italic><sup>2</sup>=0.332; <italic>P</italic><0.001), CRP (<italic>r</italic><sup>2</sup>=0.314; <italic>P</italic><0.001), and mGPS (<italic>r</italic><sup>2</sup>=0.336; <italic>P</italic><0.001), and negatively with Karnofsky Performance Score (<italic>r</italic><sup>2</sup>=−0.269; <italic>P</italic><0.001). However, although MIC-1 correlated weakly with dietary intake (r<sup>2</sup>=0.157; <italic>P</italic>=0.031), it did not correlate with weight loss, BMI, or anthropometry. Patients with MIC-1 levels in the upper quartile showed reduced survival (median=204 days; 95% CI 157–251) when compared with patients with MIC-1 levels in the lower three quartiles (median=316 days; 95% CI 259–373; <italic>P</italic>=0.036), but MIC-1 was not an independent prognostic indicator.</p></sec><sec><title>Conclusions:</title><p>There is no independent link between plasma MIC-1 levels and depleted nutritional status or survival in OGC.</p></sec></abstract><kwd-group><kwd>macrophage inhibitory cytokine 1</kwd><kwd>oesophageal cancer</kwd><kwd>gastric cancer</kwd><kwd>cachexia</kwd><kwd>survival</kwd><kwd>nutrition</kwd></kwd-group></article-meta></front><floats-wrap><fig id="fig1"><label>Figure 1</label><caption><p>Box plot showing increased plasma MIC-1 concentration in oesophago-gastric cancer patients when compared with the controls (<italic>P</italic><0.001).</p></caption><graphic mime-subtype="eps" xlink:href="6605532f1"></graphic></fig><fig id="fig2"><label>Figure 2</label><caption><p>Box plot showing increasing plasma MIC-1 concentration with increasing distal situation of the primary tumour (<italic>P</italic>=0.015).</p></caption><graphic mime-subtype="eps" xlink:href="6605532f2"></graphic></fig><fig id="fig3"><label>Figure 3</label><caption><p>Box plot showing increasing plasma MIC-1 concentration with worsening tumour grade (<italic>P</italic>=0.010).</p></caption><graphic mime-subtype="eps" xlink:href="6605532f3"></graphic></fig><fig id="fig4"><label>Figure 4</label><caption><p>Box plot showing increasing plasma MIC-1 concentration with worsening disease stage (<italic>P</italic>=0.002).</p></caption><graphic mime-subtype="eps" xlink:href="6605532f4"></graphic></fig><fig id="fig5"><label>Figure 5</label><caption><p>Box plot showing increasing plasma MIC-1 concentration with increasing modified Glasgow Prognostic Score (<italic>P</italic><0.001).</p></caption><graphic mime-subtype="eps" xlink:href="6605532f5"></graphic></fig><fig id="fig6"><label>Figure 6</label><caption><p>Dot plot of MIC-1 <italic>vs</italic> CRP (linear <italic>r</italic><sup>2</sup>=0.059).</p></caption><graphic mime-subtype="eps" xlink:href="6605532f6"></graphic></fig><fig id="fig7"><label>Figure 7</label><caption><p>Kaplan–Meier plot of survival of oesophago-gastric cancer patients according to plasma MIC-1 concentration. Patients with MIC-1 concentrations in the upper quartile showed worsened survival (median 204 days; 95% CI 157–251) when compared with patients with MIC-1 concentrations in the lower three quartiles (median 316 days; 95% CI 259–373; <italic>P</italic>=0.036, log-rank test).</p></caption><graphic mime-subtype="eps" xlink:href="6605532f7"></graphic></fig><table-wrap id="tbl1" position="float"><label>Table 1</label><caption><p content-type="table-title">Demographics, nutritional status, and plasma concentrations of inflammatory mediators of the oesophago-gastric cancer patients. Data are presented as medians with ranges.</p></caption><table frame="hsides" rules="groups" border="1" width="85%"><colgroup><col align="left"></col><col align="center"></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50"> </th><th align="center" valign="top" charoff="50"><bold>Patients (<italic>n</italic>=293)</bold></th></tr></thead><tbody valign="top"><tr><td align="left" valign="top" charoff="50"><italic>Male:female</italic></td><td align="center" valign="top" charoff="50">198 : 95</td></tr><tr><td align="left" valign="top" charoff="50"><italic>Age</italic> (years)</td><td align="char" valign="top" char="(" charoff="50">70 (26–91)</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td></tr><tr><td colspan="2" align="left" valign="top" charoff="50"><italic>Tumour site</italic></td></tr><tr><td align="left" valign="top" charoff="50"> Oesophageal</td><td align="center" valign="top" charoff="50">139</td></tr><tr><td align="left" valign="top" charoff="50"> OGJ</td><td align="center" valign="top" charoff="50">51</td></tr><tr><td align="left" valign="top" charoff="50"> Gastric</td><td align="center" valign="top" charoff="50">103</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td></tr><tr><td colspan="2" align="left" valign="top" charoff="50"><italic>Histology</italic></td></tr><tr><td align="left" valign="top" charoff="50"> Adenocarcinoma</td><td align="center" valign="top" charoff="50">242</td></tr><tr><td align="left" valign="top" charoff="50"> Squamous</td><td align="center" valign="top" charoff="50">43</td></tr><tr><td align="left" valign="top" charoff="50"> Undifferentiated</td><td align="center" valign="top" charoff="50">6</td></tr><tr><td align="left" valign="top" charoff="50"> Neuroendocrine</td><td align="center" valign="top" charoff="50">2</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td></tr><tr><td colspan="2" align="left" valign="top" charoff="50"><italic>Disease stage</italic></td></tr><tr><td align="left" valign="top" charoff="50"> I</td><td align="center" valign="top" charoff="50">36</td></tr><tr><td align="left" valign="top" charoff="50"> II</td><td align="center" valign="top" charoff="50">45</td></tr><tr><td align="left" valign="top" charoff="50"> III</td><td align="center" valign="top" charoff="50">106</td></tr><tr><td align="left" valign="top" charoff="50"> IV</td><td align="center" valign="top" charoff="50">97</td></tr><tr><td align="left" valign="top" charoff="50"> Unknown</td><td align="center" valign="top" charoff="50">46</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td></tr><tr><td align="left" valign="top" charoff="50"><italic>Body mass index</italic> (kg m<sup>–2</sup>)</td><td align="char" valign="top" char="(" charoff="50">24.6 (13.9–46.7)</td></tr><tr><td align="left" valign="top" charoff="50"><italic>Weight loss</italic> (% loss of pre-morbid weight)</td><td align="char" valign="top" char="(" charoff="50">6.4 (0.0–33.4)</td></tr><tr><td align="left" valign="top" charoff="50"><italic>Mid-arm muscle circumference</italic> (cm)</td><td align="char" valign="top" char="(" charoff="50">23.8 (15.6–32.10)</td></tr><tr><td align="left" valign="top" charoff="50"><italic>Triceps skin-fold thickness</italic> (mm)</td><td align="char" valign="top" char="(" charoff="50">12.0 (3.0–52.0)</td></tr><tr><td align="left" valign="top" charoff="50"><italic>KPS</italic></td><td align="char" valign="top" char="(" charoff="50">90 (30–100)</td></tr><tr><td align="left" valign="top" charoff="50"><italic>CRP</italic> (mg l<sup>–1</sup>)</td><td align="char" valign="top" char="(" charoff="50">9.0 (1.0–200.0)</td></tr><tr><td align="left" valign="top" charoff="50"><italic>MIC-1</italic> (pg ml<sup>–1</sup>)</td><td align="center" valign="top" charoff="50">1246.5 (140.7–39 052.9)</td></tr></tbody></table><table-wrap-foot><fn id="t1-fn1"><label></label><p>Abbreviations: CRP=C-reactive protein; KPS=Karnofsky performance score; MIC-1=macrophage inhibitory cytokine-1.</p></fn></table-wrap-foot></table-wrap><table-wrap id="tbl2" position="float"><label>Table 2</label><caption><p content-type="table-title">Correlations between inflammatory mediators and nutritional status</p></caption><table frame="hsides" rules="groups" border="1" width="85%"><colgroup><col align="left"></col><col align="left"></col><col align="char" char="."></col><col align="char" char="."></col><col align="left"></col><col align="char" char="."></col><col align="char" char="."></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50"><bold>Inflammatory mediator</bold></th><th align="left" valign="top" charoff="50"><bold>Positive correlates</bold></th><th align="char" valign="top" char="." charoff="50"><bold><italic>r</italic><sup>2</sup></bold></th><th align="char" valign="top" char="." charoff="50"><bold><italic>P</italic>-value</bold></th><th align="left" valign="top" charoff="50"><bold>Negative correlates</bold></th><th align="char" valign="top" char="." charoff="50"><bold><italic>r</italic><sup>2</sup></bold></th><th align="char" valign="top" char="." charoff="50"><bold><italic>P</italic>-value</bold></th></tr></thead><tbody valign="top"><tr><td align="left" valign="top" charoff="50">MIC-1</td><td align="left" valign="top" charoff="50">CRP</td><td align="char" valign="top" char="." charoff="50">0.314</td><td align="char" valign="top" char="." charoff="50"><0.001</td><td align="left" valign="top" charoff="50">Albumin</td><td align="char" valign="top" char="." charoff="50">−0.316</td><td align="char" valign="top" char="." charoff="50"><0.001</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50">mGPS</td><td align="char" valign="top" char="." charoff="50">0.336</td><td align="char" valign="top" char="." charoff="50"><0.001</td><td align="left" valign="top" charoff="50">KPS</td><td align="char" valign="top" char="." charoff="50">−0.269</td><td align="char" valign="top" char="." charoff="50"><0.001</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50">Age</td><td align="char" valign="top" char="." charoff="50">0.332</td><td align="char" valign="top" char="." charoff="50"><0.001</td><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50">Tumour grade</td><td align="char" valign="top" char="." charoff="50">0.234</td><td align="char" valign="top" char="." charoff="50">0.002</td><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50">Stage</td><td align="char" valign="top" char="." charoff="50">0.217</td><td align="char" valign="top" char="." charoff="50"><0.001</td><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50">Diet score</td><td align="char" valign="top" char="." charoff="50">0.157</td><td align="char" valign="top" char="." charoff="50">0.031</td><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td></tr><tr><td align="left" valign="top" charoff="50">CRP</td><td align="left" valign="top" charoff="50">MIC-1</td><td align="char" valign="top" char="." charoff="50">0.314</td><td align="char" valign="top" char="." charoff="50"><0.001</td><td align="left" valign="top" charoff="50">Albumin</td><td align="char" valign="top" char="." charoff="50">−0.489</td><td align="char" valign="top" char="." charoff="50"><0.001</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50">Tumour grade</td><td align="char" valign="top" char="." charoff="50">0.341</td><td align="char" valign="top" char="." charoff="50"><0.001</td><td align="left" valign="top" charoff="50">KPS</td><td align="char" valign="top" char="." charoff="50">−0.257</td><td align="char" valign="top" char="." charoff="50"><0.001</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50">Stage</td><td align="char" valign="top" char="." charoff="50">0.220</td><td align="char" valign="top" char="." charoff="50"><0.001</td><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50">% Weight loss</td><td align="char" valign="top" char="." charoff="50">0.247</td><td align="char" valign="top" char="." charoff="50"><0.001</td><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50">Diet score</td><td align="char" valign="top" char="." charoff="50">0.265</td><td align="char" valign="top" char="." charoff="50"><0.001</td><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td></tr><tr><td align="left" valign="top" charoff="50">mGPS</td><td align="left" valign="top" charoff="50">MIC-1</td><td align="char" valign="top" char="." charoff="50">0.336</td><td align="char" valign="top" char="." charoff="50"><0.001</td><td align="left" valign="top" charoff="50">MAMC</td><td align="char" valign="top" char="." charoff="50">−0.318</td><td align="char" valign="top" char="." charoff="50"><0.001</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50">Tumour grade</td><td align="char" valign="top" char="." charoff="50">0.268</td><td align="char" valign="top" char="." charoff="50">0.001</td><td align="left" valign="top" charoff="50">KPS</td><td align="char" valign="top" char="." charoff="50">−0.362</td><td align="char" valign="top" char="." charoff="50"><0.001</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50">Stage</td><td align="char" valign="top" char="." charoff="50">0.234</td><td align="char" valign="top" char="." charoff="50">0.001</td><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50">% Weight loss</td><td align="char" valign="top" char="." charoff="50">0.280</td><td align="char" valign="top" char="." charoff="50"><0.001</td><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50">Diet score</td><td align="char" valign="top" char="." charoff="50">0.262</td><td align="char" valign="top" char="." charoff="50"><0.001</td><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td></tr></tbody></table><table-wrap-foot><fn id="t2-fn1"><label></label><p>Abbreviations: CRP=C-reactive protein; KPS=Karnofsky performance score; MAMC=mid-arm muscle circumference; mGPS=modified Glasgow Prognostic Score; MIC-1=macrophage inhibitory cytokine-1.</p></fn></table-wrap-foot></table-wrap><table-wrap id="tbl3" position="float"><label>Table 3</label><caption><p content-type="table-title">Results of the regression models of CRP (<italic>r</italic><sup>2</sup>=0.179) and percentage weight loss (<italic>r</italic><sup>2</sup>=0.259) demonstrating significant determinants</p></caption><table frame="hsides" rules="groups" border="1" width="85%"><colgroup><col align="left"></col><col align="left"></col><col align="char" char="."></col><col align="char" char="."></col><col align="left"></col><col align="char" char="."></col><col align="char" char="."></col><col align="char" char="."></col><col align="char" char="."></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50"> </th><th align="left" valign="top" charoff="50"> </th><th colspan="2" align="center" valign="top" char="." charoff="50"><bold>Unstandardised coefficients</bold></th><th align="left" valign="top" charoff="50"><bold>Standardised coefficients</bold></th><th align="char" valign="top" char="." charoff="50"> </th><th align="char" valign="top" char="." charoff="50"> </th><th colspan="2" align="center" valign="top" char="." charoff="50"><bold>95% CI for B</bold></th></tr><tr><th align="left" valign="top" charoff="50"><bold>Model</bold></th><th align="left" valign="top" charoff="50"><bold>Factor</bold></th><th align="char" valign="top" char="." charoff="50"><bold>B</bold></th><th align="char" valign="top" char="." charoff="50"><bold>Standard error</bold></th><th align="left" valign="top" charoff="50"><bold>β</bold></th><th align="char" valign="top" char="." charoff="50"><bold><italic>t</italic></bold></th><th align="char" valign="top" char="." charoff="50"><bold><italic>P-</italic>value</bold></th><th align="char" valign="top" char="." charoff="50"><bold>Lower boundary</bold></th><th align="char" valign="top" char="." charoff="50"><bold>Upper boundary</bold></th></tr></thead><tbody valign="top"><tr><td align="left" valign="top" charoff="50">CRP</td><td align="left" valign="top" charoff="50">(Constant)</td><td align="char" valign="top" char="." charoff="50">−35.759</td><td align="char" valign="top" char="." charoff="50">13.387</td><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50">−2.671</td><td align="char" valign="top" char="." charoff="50">0.008</td><td align="char" valign="top" char="." charoff="50">−62.213</td><td align="char" valign="top" char="." charoff="50">−9.305</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50">MIC-1</td><td align="char" valign="top" char="." charoff="50">0.005</td><td align="char" valign="top" char="." charoff="50">0.002</td><td align="char" valign="top" char="." charoff="50">0.231</td><td align="char" valign="top" char="." charoff="50">3.001</td><td align="char" valign="top" char="." charoff="50">0.003</td><td align="char" valign="top" char="." charoff="50">0.002</td><td align="char" valign="top" char="." charoff="50">0.008</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50">Diet score</td><td align="char" valign="top" char="." charoff="50">12.613</td><td align="char" valign="top" char="." charoff="50">3.670</td><td align="char" valign="top" char="." charoff="50">0.258</td><td align="char" valign="top" char="." charoff="50">3.437</td><td align="char" valign="top" char="." charoff="50">0.001</td><td align="char" valign="top" char="." charoff="50">5.361</td><td align="char" valign="top" char="." charoff="50">19.864</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50">Tumour grade</td><td align="char" valign="top" char="." charoff="50">9.977</td><td align="char" valign="top" char="." charoff="50">4.628</td><td align="char" valign="top" char="." charoff="50">0.165</td><td align="char" valign="top" char="." charoff="50">2.156</td><td align="char" valign="top" char="." charoff="50">0.033</td><td align="char" valign="top" char="." charoff="50">0.832</td><td align="char" valign="top" char="." charoff="50">19.123</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td></tr><tr><td align="left" valign="top" charoff="50">% Weight loss</td><td align="left" valign="top" charoff="50">(Constant)</td><td align="char" valign="top" char="." charoff="50">−3.788</td><td align="char" valign="top" char="." charoff="50">2.107</td><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50">−1.798</td><td align="char" valign="top" char="." charoff="50">0.074</td><td align="char" valign="top" char="." charoff="50">−7.946</td><td align="char" valign="top" char="." charoff="50">0.370</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50">Diet score</td><td align="char" valign="top" char="." charoff="50">2.871</td><td align="char" valign="top" char="." charoff="50">1.066</td><td align="char" valign="top" char="." charoff="50">0.221</td><td align="char" valign="top" char="." charoff="50">2.693</td><td align="char" valign="top" char="." charoff="50">0.008</td><td align="char" valign="top" char="." charoff="50">0.767</td><td align="char" valign="top" char="." charoff="50">4.975</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50">mGPS</td><td align="char" valign="top" char="." charoff="50">2.491</td><td align="char" valign="top" char="." charoff="50">0.835</td><td align="char" valign="top" char="." charoff="50">0.205</td><td align="char" valign="top" char="." charoff="50">2.983</td><td align="char" valign="top" char="." charoff="50">0.003</td><td align="char" valign="top" char="." charoff="50">0.843</td><td align="char" valign="top" char="." charoff="50">4.140</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50">Stage</td><td align="char" valign="top" char="." charoff="50">1.459</td><td align="char" valign="top" char="." charoff="50">0.639</td><td align="char" valign="top" char="." charoff="50">0.161</td><td align="char" valign="top" char="." charoff="50">2.284</td><td align="char" valign="top" char="." charoff="50">0.024</td><td align="char" valign="top" char="." charoff="50">0.198</td><td align="char" valign="top" char="." charoff="50">2.719</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50">Dysphagia score</td><td align="char" valign="top" char="." charoff="50">1.182</td><td align="char" valign="top" char="." charoff="50">0.583</td><td align="char" valign="top" char="." charoff="50">0.155</td><td align="char" valign="top" char="." charoff="50">2.028</td><td align="char" valign="top" char="." charoff="50">0.044</td><td align="char" valign="top" char="." charoff="50">0.031</td><td align="char" valign="top" char="." charoff="50">2.333</td></tr></tbody></table><table-wrap-foot><fn id="t3-fn1"><label></label><p>Abbreviations: CI=confidence interval; CRP=C-reactive protein; mGPS=modified Glasgow Prognostic Score; MIC-1=macrophage inhibitory cytokine-1.</p></fn></table-wrap-foot></table-wrap><table-wrap id="tbl4" position="float"><label>Table 4</label><caption><p content-type="table-title">Results of the Cox's proportional hazards model demonstrating significant determinants of oesophago-gastric cancer patient survival</p></caption><table frame="hsides" rules="groups" border="1" width="85%"><colgroup><col align="left"></col><col align="char" char="."></col><col align="char" char="."></col><col align="char" char="."></col><col align="center"></col><col align="char" char="."></col><col align="char" char="."></col><col align="char" char="."></col><col align="char" char="."></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50"> </th><th align="char" valign="top" char="." charoff="50"> </th><th align="char" valign="top" char="." charoff="50"> </th><th align="char" valign="top" char="." charoff="50"> </th><th align="center" valign="top" charoff="50"> </th><th align="char" valign="top" char="." charoff="50"> </th><th align="char" valign="top" char="." charoff="50"> </th><th colspan="2" align="center" valign="top" char="." charoff="50"><bold>95% CI</bold></th></tr><tr><th align="left" valign="top" charoff="50"> </th><th align="char" valign="top" char="." charoff="50"><bold>B</bold></th><th align="char" valign="top" char="." charoff="50"><bold>SE</bold></th><th align="char" valign="top" char="." charoff="50"><bold>Wald</bold></th><th align="center" valign="top" charoff="50"><bold>d.f.</bold></th><th align="char" valign="top" char="." charoff="50"><bold><italic>P-</italic>value</bold></th><th align="char" valign="top" char="." charoff="50"><bold>Hazard ratio</bold></th><th align="char" valign="top" char="." charoff="50"><bold>Lower boundary</bold></th><th align="char" valign="top" char="." charoff="50"><bold>Upper boundary</bold></th></tr></thead><tbody valign="top"><tr><td align="left" valign="top" charoff="50">Stage</td><td align="char" valign="top" char="." charoff="50">0.682</td><td align="char" valign="top" char="." charoff="50">0.177</td><td align="char" valign="top" char="." charoff="50">14.902</td><td align="center" valign="top" charoff="50">1</td><td align="char" valign="top" char="." charoff="50"><0.001</td><td align="char" valign="top" char="." charoff="50">1.979</td><td align="char" valign="top" char="." charoff="50">1.399</td><td align="char" valign="top" char="." charoff="50">2.798</td></tr><tr><td align="left" valign="top" charoff="50">Treatment regimen</td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50">13.934</td><td align="center" valign="top" charoff="50">3</td><td align="char" valign="top" char="." charoff="50">0.003</td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td></tr><tr><td align="left" valign="top" charoff="50">CRP</td><td align="char" valign="top" char="." charoff="50">0.006</td><td align="char" valign="top" char="." charoff="50">0.003</td><td align="char" valign="top" char="." charoff="50">4.498</td><td align="center" valign="top" charoff="50">1</td><td align="char" valign="top" char="." charoff="50">0.034</td><td align="char" valign="top" char="." charoff="50">1.006</td><td align="char" valign="top" char="." charoff="50">1.000</td><td align="char" valign="top" char="." charoff="50">1.012</td></tr><tr><td align="left" valign="top" charoff="50">% Weight loss</td><td align="char" valign="top" char="." charoff="50">0.038</td><td align="char" valign="top" char="." charoff="50">0.013</td><td align="char" valign="top" char="." charoff="50">9.232</td><td align="center" valign="top" charoff="50">1</td><td align="char" valign="top" char="." charoff="50">0.002</td><td align="char" valign="top" char="." charoff="50">1.039</td><td align="char" valign="top" char="." charoff="50">1.014</td><td align="char" valign="top" char="." charoff="50">1.065</td></tr></tbody></table><table-wrap-foot><fn id="t4-fn1"><label></label><p>Abbreviations: CI=confidence interval; CRP=C-reactive protein.</p></fn></table-wrap-foot></table-wrap></floats-wrap></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000025 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000025 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:2837566
|texte= Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:20104227" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |