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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Chronic Myeloid Leukemia: An Update of Concepts and Management Recommendations of European LeukemiaNet</title><author><name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Cortes, Jorge" sort="Cortes, Jorge" uniqKey="Cortes J" first="Jorge" last="Cortes">Jorge Cortes</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Pane, Fabrizio" sort="Pane, Fabrizio" uniqKey="Pane F" first="Fabrizio" last="Pane">Fabrizio Pane</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Niederwieser, Dietger" sort="Niederwieser, Dietger" uniqKey="Niederwieser D" first="Dietger" last="Niederwieser">Dietger Niederwieser</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Saglio, Giuseppe" sort="Saglio, Giuseppe" uniqKey="Saglio G" first="Giuseppe" last="Saglio">Giuseppe Saglio</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Apperley, Jane" sort="Apperley, Jane" uniqKey="Apperley J" first="Jane" last="Apperley">Jane Apperley</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Cervantes, Francisco" sort="Cervantes, Francisco" uniqKey="Cervantes F" first="Francisco" last="Cervantes">Francisco Cervantes</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Deininger, Michael" sort="Deininger, Michael" uniqKey="Deininger M" first="Michael" last="Deininger">Michael Deininger</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Gratwohl, Alois" sort="Gratwohl, Alois" uniqKey="Gratwohl A" first="Alois" last="Gratwohl">Alois Gratwohl</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Guilhot, Francois" sort="Guilhot, Francois" uniqKey="Guilhot F" first="François" last="Guilhot">François Guilhot</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Hochhaus, Andreas" sort="Hochhaus, Andreas" uniqKey="Hochhaus A" first="Andreas" last="Hochhaus">Andreas Hochhaus</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Horowitz, Mary" sort="Horowitz, Mary" uniqKey="Horowitz M" first="Mary" last="Horowitz">Mary Horowitz</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Hughes, Timothy" sort="Hughes, Timothy" uniqKey="Hughes T" first="Timothy" last="Hughes">Timothy Hughes</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Kantarjian, Hagop" sort="Kantarjian, Hagop" uniqKey="Kantarjian H" first="Hagop" last="Kantarjian">Hagop Kantarjian</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Larson, Richard" sort="Larson, Richard" uniqKey="Larson R" first="Richard" last="Larson">Richard Larson</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Radich, Jerald" sort="Radich, Jerald" uniqKey="Radich J" first="Jerald" last="Radich">Jerald Radich</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Simonsson, Bengt" sort="Simonsson, Bengt" uniqKey="Simonsson B" first="Bengt" last="Simonsson">Bengt Simonsson</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Silver, Richard T" sort="Silver, Richard T" uniqKey="Silver R" first="Richard T." last="Silver">Richard T. Silver</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Goldman, John" sort="Goldman, John" uniqKey="Goldman J" first="John" last="Goldman">John Goldman</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Hehlmann, Rudiger" sort="Hehlmann, Rudiger" uniqKey="Hehlmann R" first="Rudiger" last="Hehlmann">Rudiger Hehlmann</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19884523</idno><idno type="pmc">4979100</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979100</idno><idno type="RBID">PMC:4979100</idno><idno type="doi">10.1200/JCO.2009.25.0779</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">002E88</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E88</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Chronic Myeloid Leukemia: An Update of Concepts and Management Recommendations of European LeukemiaNet</title><author><name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Cortes, Jorge" sort="Cortes, Jorge" uniqKey="Cortes J" first="Jorge" last="Cortes">Jorge Cortes</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Pane, Fabrizio" sort="Pane, Fabrizio" uniqKey="Pane F" first="Fabrizio" last="Pane">Fabrizio Pane</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Niederwieser, Dietger" sort="Niederwieser, Dietger" uniqKey="Niederwieser D" first="Dietger" last="Niederwieser">Dietger Niederwieser</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Saglio, Giuseppe" sort="Saglio, Giuseppe" uniqKey="Saglio G" first="Giuseppe" last="Saglio">Giuseppe Saglio</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Apperley, Jane" sort="Apperley, Jane" uniqKey="Apperley J" first="Jane" last="Apperley">Jane Apperley</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Cervantes, Francisco" sort="Cervantes, Francisco" uniqKey="Cervantes F" first="Francisco" last="Cervantes">Francisco Cervantes</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Deininger, Michael" sort="Deininger, Michael" uniqKey="Deininger M" first="Michael" last="Deininger">Michael Deininger</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Gratwohl, Alois" sort="Gratwohl, Alois" uniqKey="Gratwohl A" first="Alois" last="Gratwohl">Alois Gratwohl</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Guilhot, Francois" sort="Guilhot, Francois" uniqKey="Guilhot F" first="François" last="Guilhot">François Guilhot</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Hochhaus, Andreas" sort="Hochhaus, Andreas" uniqKey="Hochhaus A" first="Andreas" last="Hochhaus">Andreas Hochhaus</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Horowitz, Mary" sort="Horowitz, Mary" uniqKey="Horowitz M" first="Mary" last="Horowitz">Mary Horowitz</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Hughes, Timothy" sort="Hughes, Timothy" uniqKey="Hughes T" first="Timothy" last="Hughes">Timothy Hughes</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Kantarjian, Hagop" sort="Kantarjian, Hagop" uniqKey="Kantarjian H" first="Hagop" last="Kantarjian">Hagop Kantarjian</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Larson, Richard" sort="Larson, Richard" uniqKey="Larson R" first="Richard" last="Larson">Richard Larson</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Radich, Jerald" sort="Radich, Jerald" uniqKey="Radich J" first="Jerald" last="Radich">Jerald Radich</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Simonsson, Bengt" sort="Simonsson, Bengt" uniqKey="Simonsson B" first="Bengt" last="Simonsson">Bengt Simonsson</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Silver, Richard T" sort="Silver, Richard T" uniqKey="Silver R" first="Richard T." last="Silver">Richard T. Silver</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Goldman, John" sort="Goldman, John" uniqKey="Goldman J" first="John" last="Goldman">John Goldman</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author><author><name sortKey="Hehlmann, Rudiger" sort="Hehlmann, Rudiger" uniqKey="Hehlmann R" first="Rudiger" last="Hehlmann">Rudiger Hehlmann</name><affiliation><nlm:aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Clinical Oncology</title><idno type="ISSN">0732-183X</idno><idno type="eISSN">1527-7755</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>To review and update the European LeukemiaNet (ELN) recommendations for the management of chronic myeloid leukemia with imatinib and second-generation tyrosine kinase inhibitors (TKIs), including monitoring, response definition, and first- and second-line therapy.</p></sec><sec><title>Methods</title><p>These recommendations are based on a critical and comprehensive review of the relevant papers up to February 2009 and the results of four consensus conferences held by the panel of experts appointed by ELN in 2008.</p></sec><sec><title>Results</title><p>Cytogenetic monitoring was required at 3, 6, 12, and 18 months. Molecular monitoring was required every 3 months. On the basis of the degree and the timing of hematologic, cytogenetic, and molecular results, the response to first-line imatinib was defined as optimal, suboptimal, or failure, and the response to second-generation TKIs was defined as suboptimal or failure.</p></sec><sec><title>Conclusion</title><p>Initial treatment was confirmed as imatinib 400 mg daily. Imatinib should be continued indefinitely in optimal responders. Suboptimal responders may continue on imatinb, at the same or higher dose, or may be eligible for investigational therapy with second-generation TKIs. In instances of imatinib failure, second-generation TKIs are recommended, followed by allogeneic hematopoietic stem-cell transplantation only in instances of failure and, sometimes, suboptimal response, depending on transplantation risk.</p></sec></div></front></TEI><pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Oncol</journal-id><journal-id journal-id-type="iso-abbrev">J. Clin. Oncol</journal-id><journal-id journal-id-type="hwp">jco</journal-id><journal-id journal-id-type="pmc">jco</journal-id><journal-id journal-id-type="publisher-id">JCO</journal-id><journal-title-group><journal-title>Journal of Clinical Oncology</journal-title></journal-title-group><issn pub-type="ppub">0732-183X</issn><issn pub-type="epub">1527-7755</issn><publisher><publisher-name>American Society of Clinical Oncology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">19884523</article-id><article-id pub-id-type="pmc">4979100</article-id><article-id pub-id-type="publisher-id">r0779</article-id><article-id pub-id-type="doi">10.1200/JCO.2009.25.0779</article-id><article-categories><subj-group subj-group-type="collcodes"><subject>Hema7</subject></subj-group><subj-group subj-group-type="heading"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title>Chronic Myeloid Leukemia: An Update of Concepts and Management Recommendations of European LeukemiaNet</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Baccarani</surname><given-names>Michele</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Cortes</surname><given-names>Jorge</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Pane</surname><given-names>Fabrizio</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Niederwieser</surname><given-names>Dietger</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Saglio</surname><given-names>Giuseppe</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Apperley</surname><given-names>Jane</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Cervantes</surname><given-names>Francisco</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Deininger</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Gratwohl</surname><given-names>Alois</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Guilhot</surname><given-names>François</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Hochhaus</surname><given-names>Andreas</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Horowitz</surname><given-names>Mary</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Hughes</surname><given-names>Timothy</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Kantarjian</surname><given-names>Hagop</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Larson</surname><given-names>Richard</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Radich</surname><given-names>Jerald</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Simonsson</surname><given-names>Bengt</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Silver</surname><given-names>Richard T.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Goldman</surname><given-names>John</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Hehlmann</surname><given-names>Rudiger</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><aff id="aff1">From the Department of Hematology/Oncology, L. and A. Seràgnolì, University of Bologna; Division of Hematology, University Federico II, Naples; and Department of Clinical and Biological Sciences, University of Turin at Orbassano, Turin, Italy; Department of Haematology, Hammersmith Hospital; and Department of Haematology, Imperial College, London, United Kingdom; Hematology Department, Hospital Clinic, lnstitut d'lnvestigations Biomédiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Department of Hematology, University Hospital, Basel, Switzerland; CIC 802 INSERM, CHU de Poitiers, Poitiers, France; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Department of Medicine and Cancer Research Center, University of Chicago, Chicago, IL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Hematology, University Hospital, Uppsala, Sweden; New York Presbyterian-Weill Cornell Medical Center, New York, NY; Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR; Department of Hematology and Oncology, University of Leipzig, Leipzig; Universitätsklinikum Jena, Jena; and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</aff></contrib-group><author-notes><corresp id="cor1">Corresponding author: Michele Baccarani, MD, Department of Hematology-Oncology, L. and A. Seràgnoli, S. Orsola-Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy; e-mail: <email>michele.baccarani@unibo.it</email>.</corresp></author-notes><pub-date pub-type="ppub"><day>10</day><month>12</month><year>2009</year></pub-date><pub-date pub-type="epub"><day>2</day><month>11</month><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>2</day><month>11</month><year>2009</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>27</volume><issue>35</issue><fpage>6041</fpage><lpage>6051</lpage><history><date date-type="received"><day>13</day><month>7</month><year>2009</year></date><date date-type="accepted"><day>27</day><month>8</month><year>2009</year></date></history><permissions><copyright-statement>© 2009 by American Society of Clinical Oncology</copyright-statement><copyright-year>2009</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zlj03509006041.pdf"></self-uri><abstract><sec><title>Purpose</title><p>To review and update the European LeukemiaNet (ELN) recommendations for the management of chronic myeloid leukemia with imatinib and second-generation tyrosine kinase inhibitors (TKIs), including monitoring, response definition, and first- and second-line therapy.</p></sec><sec><title>Methods</title><p>These recommendations are based on a critical and comprehensive review of the relevant papers up to February 2009 and the results of four consensus conferences held by the panel of experts appointed by ELN in 2008.</p></sec><sec><title>Results</title><p>Cytogenetic monitoring was required at 3, 6, 12, and 18 months. Molecular monitoring was required every 3 months. On the basis of the degree and the timing of hematologic, cytogenetic, and molecular results, the response to first-line imatinib was defined as optimal, suboptimal, or failure, and the response to second-generation TKIs was defined as suboptimal or failure.</p></sec><sec><title>Conclusion</title><p>Initial treatment was confirmed as imatinib 400 mg daily. Imatinib should be continued indefinitely in optimal responders. Suboptimal responders may continue on imatinb, at the same or higher dose, or may be eligible for investigational therapy with second-generation TKIs. In instances of imatinib failure, second-generation TKIs are recommended, followed by allogeneic hematopoietic stem-cell transplantation only in instances of failure and, sometimes, suboptimal response, depending on transplantation risk.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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