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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>Cryptococcus neoformans</italic> and <italic>Cryptococcus gattii</italic>, the Etiologic Agents of Cryptococcosis</title><author><name sortKey="Kwon Chung, Kyung J" sort="Kwon Chung, Kyung J" uniqKey="Kwon Chung K" first="Kyung J." last="Kwon-Chung">Kyung J. Kwon-Chung</name><affiliation><nlm:aff id="af1">Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892</nlm:aff></affiliation></author><author><name sortKey="Fraser, James A" sort="Fraser, James A" uniqKey="Fraser J" first="James A." last="Fraser">James A. Fraser</name><affiliation><nlm:aff id="af2">Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland 4072, Australia</nlm:aff></affiliation></author><author><name sortKey="Doering, Tamara L" sort="Doering, Tamara L" uniqKey="Doering T" first="Tamara L." last="Doering">Tamara L. Doering</name><affiliation><nlm:aff id="af3">Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110</nlm:aff></affiliation></author><author><name sortKey="Wang, Zhou" sort="Wang, Zhou" uniqKey="Wang Z" first="Zhou" last="Wang">Zhou Wang</name><affiliation><nlm:aff id="af3">Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110</nlm:aff></affiliation></author><author><name sortKey="Janbon, Guilhem" sort="Janbon, Guilhem" uniqKey="Janbon G" first="Guilhem" last="Janbon">Guilhem Janbon</name><affiliation><nlm:aff id="af4">Unité Biologie et Pathogénicité Fongiques, Institut Pasteur, 75015 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Idnurm, Alexander" sort="Idnurm, Alexander" uniqKey="Idnurm A" first="Alexander" last="Idnurm">Alexander Idnurm</name><affiliation><nlm:aff id="af5">Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri, Kansas City, Missouri 64110</nlm:aff></affiliation></author><author><name sortKey="Bahn, Yong Sun" sort="Bahn, Yong Sun" uniqKey="Bahn Y" first="Yong-Sun" last="Bahn">Yong-Sun Bahn</name><affiliation><nlm:aff id="af6">Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 120–749, Republic of Korea</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24985132</idno><idno type="pmc">4066639</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066639</idno><idno type="RBID">PMC:4066639</idno><idno type="doi">10.1101/cshperspect.a019760</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002E80</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E80</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>Cryptococcus neoformans</italic> and <italic>Cryptococcus gattii</italic>, the Etiologic Agents of Cryptococcosis</title><author><name sortKey="Kwon Chung, Kyung J" sort="Kwon Chung, Kyung J" uniqKey="Kwon Chung K" first="Kyung J." last="Kwon-Chung">Kyung J. Kwon-Chung</name><affiliation><nlm:aff id="af1">Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892</nlm:aff></affiliation></author><author><name sortKey="Fraser, James A" sort="Fraser, James A" uniqKey="Fraser J" first="James A." last="Fraser">James A. Fraser</name><affiliation><nlm:aff id="af2">Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland 4072, Australia</nlm:aff></affiliation></author><author><name sortKey="Doering, Tamara L" sort="Doering, Tamara L" uniqKey="Doering T" first="Tamara L." last="Doering">Tamara L. Doering</name><affiliation><nlm:aff id="af3">Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110</nlm:aff></affiliation></author><author><name sortKey="Wang, Zhou" sort="Wang, Zhou" uniqKey="Wang Z" first="Zhou" last="Wang">Zhou Wang</name><affiliation><nlm:aff id="af3">Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110</nlm:aff></affiliation></author><author><name sortKey="Janbon, Guilhem" sort="Janbon, Guilhem" uniqKey="Janbon G" first="Guilhem" last="Janbon">Guilhem Janbon</name><affiliation><nlm:aff id="af4">Unité Biologie et Pathogénicité Fongiques, Institut Pasteur, 75015 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Idnurm, Alexander" sort="Idnurm, Alexander" uniqKey="Idnurm A" first="Alexander" last="Idnurm">Alexander Idnurm</name><affiliation><nlm:aff id="af5">Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri, Kansas City, Missouri 64110</nlm:aff></affiliation></author><author><name sortKey="Bahn, Yong Sun" sort="Bahn, Yong Sun" uniqKey="Bahn Y" first="Yong-Sun" last="Bahn">Yong-Sun Bahn</name><affiliation><nlm:aff id="af6">Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 120–749, Republic of Korea</nlm:aff></affiliation></author></analytic><series><title level="j">Cold Spring Harbor Perspectives in Medicine</title><idno type="eISSN">2157-1422</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Cryptococcosis is a fungal disease that causes more than 600,000 deaths annually; AIDS patients are particularly susceptible. Its etiologic agents possess unique specializations for virulence (e.g., melanin formation).</p></div></front></TEI><pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Cold Spring Harb Perspect Med</journal-id><journal-id journal-id-type="iso-abbrev">Cold Spring Harb Perspect Med</journal-id><journal-id journal-id-type="publisher-id">cshperspectmed</journal-id><journal-id journal-id-type="hwp">cshperspectmed</journal-id><journal-title-group><journal-title>Cold Spring Harbor Perspectives in Medicine</journal-title></journal-title-group><issn pub-type="epub">2157-1422</issn><publisher><publisher-name>Cold Spring Harbor Laboratory Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24985132</article-id><article-id pub-id-type="pmc">4066639</article-id><article-id pub-id-type="doi">10.1101/cshperspect.a019760</article-id><article-id pub-id-type="publisher-id">a019760</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>094</subject></subj-group><subj-group subj-group-type="heading"><subject>Perspectives</subject></subj-group></article-categories><title-group><article-title><italic>Cryptococcus neoformans</italic> and <italic>Cryptococcus gattii</italic>, the Etiologic Agents of Cryptococcosis</article-title><alt-title alt-title-type="left-running">K.J. Kwon-Chung et al.</alt-title><alt-title alt-title-type="right-running"><italic>C. neoformans</italic> and <italic>C. gattii</italic> in Cryptococcosis</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kwon-Chung</surname><given-names>Kyung J.</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Fraser</surname><given-names>James A.</given-names></name><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Doering</surname><given-names>Tamara L.</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Zhou</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Janbon</surname><given-names>Guilhem</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Idnurm</surname><given-names>Alexander</given-names></name><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Bahn</surname><given-names>Yong-Sun</given-names></name><xref ref-type="aff" rid="af6">6</xref></contrib></contrib-group><aff id="af1"><label>1</label>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892</aff><aff id="af2"><label>2</label>Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland 4072, Australia</aff><aff id="af3"><label>3</label>Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110</aff><aff id="af4"><label>4</label>Unité Biologie et Pathogénicité Fongiques, Institut Pasteur, 75015 Paris, France</aff><aff id="af5"><label>5</label>Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri, Kansas City, Missouri 64110</aff><aff id="af6"><label>6</label>Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 120–749, Republic of Korea</aff><author-notes><corresp><italic>Correspondence:</italic><email>jkchung@niaid.nih.gov</email></corresp><fn><p>Editors: Arturo Casadevall, Aaron P. Mitchell, Judith Berman, Kyung J. Kwon-Chung, John R. Perfect, and Joseph Heitman</p></fn><fn><p>Additional Perspectives on Human Fungal Pathogens available at <uri xlink:type="simple" xlink:href="http://www.perspectivesinmedicine.org">www.perspectivesinmedicine.org</uri></p></fn></author-notes><pub-date pub-type="ppub"><month>7</month><year>2014</year></pub-date><volume>4</volume><issue>7</issue><elocation-id>a019760</elocation-id><permissions><copyright-statement>Copyright © 2014 Cold Spring Harbor Laboratory Press; all rights reserved</copyright-statement><copyright-year>2014</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="cshperspectmed-HFP-a019760.pdf"></self-uri><abstract abstract-type="precis"><p>Cryptococcosis is a fungal disease that causes more than 600,000 deaths annually; AIDS patients are particularly susceptible. Its etiologic agents possess unique specializations for virulence (e.g., melanin formation).</p></abstract><abstract><p><italic>Cryptococcus neoformans</italic> and <italic>Cryptococcus gattii</italic> are the two etiologic agents of cryptococcosis. They belong to the phylum Basidiomycota and can be readily distinguished from other pathogenic yeasts such as <italic>Candida</italic> by the presence of a polysaccharide capsule, formation of melanin, and urease activity, which all function as virulence determinants. Infection proceeds via inhalation and subsequent dissemination to the central nervous system to cause meningoencephalitis. The most common risk for cryptococcosis caused by <italic>C. neoformans</italic> is AIDS, whereas infections caused by <italic>C. gattii</italic> are more often reported in immunocompetent patients with undefined risk than in the immunocompromised. There have been many chapters, reviews, and books written on <italic>C. neoformans.</italic> The topics we focus on in this article include species description, pathogenesis, life cycle, capsule, and stress response, which serve to highlight the specializations in virulence that have occurred in this unique encapsulated melanin-forming yeast that causes global deaths estimated at more than 600,000 annually.</p></abstract><counts><page-count count="27"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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