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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel</title><author><name sortKey="Dohner, Hartmut" sort="Dohner, Hartmut" uniqKey="Dohner H" first="Hartmut" last="Döhner">Hartmut Döhner</name><affiliation><nlm:aff id="aff1">Department of Internal Medicine III, University of Ulm, Ulm, Germany;</nlm:aff></affiliation></author><author><name sortKey="Estey, Elihu" sort="Estey, Elihu" uniqKey="Estey E" first="Elihu" last="Estey">Elihu Estey</name><affiliation><nlm:aff id="aff2">Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff></affiliation></author><author><name sortKey="Grimwade, David" sort="Grimwade, David" uniqKey="Grimwade D" first="David" last="Grimwade">David Grimwade</name><affiliation><nlm:aff id="aff3">Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Amadori, Sergio" sort="Amadori, Sergio" uniqKey="Amadori S" first="Sergio" last="Amadori">Sergio Amadori</name><affiliation><nlm:aff id="aff4">Department of Biomedicine and Prevention, Università di Roma “Tor Vergata,” Rome, Italy;</nlm:aff></affiliation></author><author><name sortKey="Appelbaum, Frederick R" sort="Appelbaum, Frederick R" uniqKey="Appelbaum F" first="Frederick R." last="Appelbaum">Frederick R. Appelbaum</name><affiliation><nlm:aff id="aff2">Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff></affiliation></author><author><name sortKey="Buchner, Thomas" sort="Buchner, Thomas" uniqKey="Buchner T" first="Thomas" last="Büchner">Thomas Büchner</name><affiliation><nlm:aff id="aff5">Department of Hematology/Oncology, University of Münster, Münster, Germany;</nlm:aff></affiliation></author><author><name sortKey="Dombret, Herve" sort="Dombret, Herve" uniqKey="Dombret H" first="Hervé" last="Dombret">Hervé Dombret</name><affiliation><nlm:aff id="aff6">Institut Universitaire d’Hématologie, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Ebert, Benjamin L" sort="Ebert, Benjamin L" uniqKey="Ebert B" first="Benjamin L." last="Ebert">Benjamin L. Ebert</name><affiliation><nlm:aff id="aff7">Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA;</nlm:aff></affiliation></author><author><name sortKey="Fenaux, Pierre" sort="Fenaux, Pierre" uniqKey="Fenaux P" first="Pierre" last="Fenaux">Pierre Fenaux</name><affiliation><nlm:aff id="aff8">Service d’Hématologie, Hôpital Saint-Louis, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Larson, Richard A" sort="Larson, Richard A" uniqKey="Larson R" first="Richard A." last="Larson">Richard A. Larson</name><affiliation><nlm:aff id="aff9">Department of Medicine, University of Chicago, Chicago, IL;</nlm:aff></affiliation></author><author><name sortKey="Levine, Ross L" sort="Levine, Ross L" uniqKey="Levine R" first="Ross L." last="Levine">Ross L. Levine</name><affiliation><nlm:aff id="aff10">Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY;</nlm:aff></affiliation></author><author><name sortKey="Lo Coco, Francesco" sort="Lo Coco, Francesco" uniqKey="Lo Coco F" first="Francesco" last="Lo-Coco">Francesco Lo-Coco</name><affiliation><nlm:aff id="aff4">Department of Biomedicine and Prevention, Università di Roma “Tor Vergata,” Rome, Italy;</nlm:aff></affiliation></author><author><name sortKey="Naoe, Tomoki" sort="Naoe, Tomoki" uniqKey="Naoe T" first="Tomoki" last="Naoe">Tomoki Naoe</name><affiliation><nlm:aff id="aff11">National Hospital Organization Nagoya Medical Center, Nagoya, Japan;</nlm:aff></affiliation></author><author><name sortKey="Niederwieser, Dietger" sort="Niederwieser, Dietger" uniqKey="Niederwieser D" first="Dietger" last="Niederwieser">Dietger Niederwieser</name><affiliation><nlm:aff id="aff12">Department of Hematology, Oncology and Hemostasis, University of Leipzig, Leipzig, Germany;</nlm:aff></affiliation></author><author><name sortKey="Ossenkoppele, Gert J" sort="Ossenkoppele, Gert J" uniqKey="Ossenkoppele G" first="Gert J." last="Ossenkoppele">Gert J. Ossenkoppele</name><affiliation><nlm:aff id="aff13">Department of Haematology, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Sanz, Miguel" sort="Sanz, Miguel" uniqKey="Sanz M" first="Miguel" last="Sanz">Miguel Sanz</name><affiliation><nlm:aff id="aff14">Department of Hematology, University Hospital La Fe, University of Valencia, Valencia, Spain;</nlm:aff></affiliation></author><author><name sortKey="Sierra, Jorge" sort="Sierra, Jorge" uniqKey="Sierra J" first="Jorge" last="Sierra">Jorge Sierra</name><affiliation><nlm:aff id="aff15">Hematology Department, Hospital de la Santa Creu i Sant Pau, Jose Carreras Leukemia Research Institute, Barcelona, Spain;</nlm:aff></affiliation></author><author><name sortKey="Tallman, Martin S" sort="Tallman, Martin S" uniqKey="Tallman M" first="Martin S." last="Tallman">Martin S. Tallman</name><affiliation><nlm:aff id="aff10">Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY;</nlm:aff></affiliation></author><author><name sortKey="Tien, Hwei Fang" sort="Tien, Hwei Fang" uniqKey="Tien H" first="Hwei-Fang" last="Tien">Hwei-Fang Tien</name><affiliation><nlm:aff id="aff16">Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan;</nlm:aff></affiliation></author><author><name sortKey="Wei, Andrew H" sort="Wei, Andrew H" uniqKey="Wei A" first="Andrew H." last="Wei">Andrew H. Wei</name><affiliation><nlm:aff id="aff17">Department of Clinical Hematology, The Alfred Hospital, Melbourne, Australia;</nlm:aff></affiliation><affiliation><nlm:aff id="aff18">Australian Centre for Blood Diseases, Monash University, Melbourne, Australia;</nlm:aff></affiliation></author><author><name sortKey="Lowenberg, Bob" sort="Lowenberg, Bob" uniqKey="Lowenberg B" first="Bob" last="Löwenberg">Bob Löwenberg</name><affiliation><nlm:aff wicri:cut="; and" id="aff19">Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Bloomfield, Clara D" sort="Bloomfield, Clara D" uniqKey="Bloomfield C" first="Clara D." last="Bloomfield">Clara D. Bloomfield</name><affiliation><nlm:aff id="aff20">The Ohio State University Comprehensive Cancer Center, Columbus, OH</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27895058</idno><idno type="pmc">5291965</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291965</idno><idno type="RBID">PMC:5291965</idno><idno type="doi">10.1182/blood-2016-08-733196</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">002E74</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E74</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel</title><author><name sortKey="Dohner, Hartmut" sort="Dohner, Hartmut" uniqKey="Dohner H" first="Hartmut" last="Döhner">Hartmut Döhner</name><affiliation><nlm:aff id="aff1">Department of Internal Medicine III, University of Ulm, Ulm, Germany;</nlm:aff></affiliation></author><author><name sortKey="Estey, Elihu" sort="Estey, Elihu" uniqKey="Estey E" first="Elihu" last="Estey">Elihu Estey</name><affiliation><nlm:aff id="aff2">Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff></affiliation></author><author><name sortKey="Grimwade, David" sort="Grimwade, David" uniqKey="Grimwade D" first="David" last="Grimwade">David Grimwade</name><affiliation><nlm:aff id="aff3">Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Amadori, Sergio" sort="Amadori, Sergio" uniqKey="Amadori S" first="Sergio" last="Amadori">Sergio Amadori</name><affiliation><nlm:aff id="aff4">Department of Biomedicine and Prevention, Università di Roma “Tor Vergata,” Rome, Italy;</nlm:aff></affiliation></author><author><name sortKey="Appelbaum, Frederick R" sort="Appelbaum, Frederick R" uniqKey="Appelbaum F" first="Frederick R." last="Appelbaum">Frederick R. Appelbaum</name><affiliation><nlm:aff id="aff2">Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff></affiliation></author><author><name sortKey="Buchner, Thomas" sort="Buchner, Thomas" uniqKey="Buchner T" first="Thomas" last="Büchner">Thomas Büchner</name><affiliation><nlm:aff id="aff5">Department of Hematology/Oncology, University of Münster, Münster, Germany;</nlm:aff></affiliation></author><author><name sortKey="Dombret, Herve" sort="Dombret, Herve" uniqKey="Dombret H" first="Hervé" last="Dombret">Hervé Dombret</name><affiliation><nlm:aff id="aff6">Institut Universitaire d’Hématologie, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Ebert, Benjamin L" sort="Ebert, Benjamin L" uniqKey="Ebert B" first="Benjamin L." last="Ebert">Benjamin L. Ebert</name><affiliation><nlm:aff id="aff7">Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA;</nlm:aff></affiliation></author><author><name sortKey="Fenaux, Pierre" sort="Fenaux, Pierre" uniqKey="Fenaux P" first="Pierre" last="Fenaux">Pierre Fenaux</name><affiliation><nlm:aff id="aff8">Service d’Hématologie, Hôpital Saint-Louis, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Larson, Richard A" sort="Larson, Richard A" uniqKey="Larson R" first="Richard A." last="Larson">Richard A. Larson</name><affiliation><nlm:aff id="aff9">Department of Medicine, University of Chicago, Chicago, IL;</nlm:aff></affiliation></author><author><name sortKey="Levine, Ross L" sort="Levine, Ross L" uniqKey="Levine R" first="Ross L." last="Levine">Ross L. Levine</name><affiliation><nlm:aff id="aff10">Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY;</nlm:aff></affiliation></author><author><name sortKey="Lo Coco, Francesco" sort="Lo Coco, Francesco" uniqKey="Lo Coco F" first="Francesco" last="Lo-Coco">Francesco Lo-Coco</name><affiliation><nlm:aff id="aff4">Department of Biomedicine and Prevention, Università di Roma “Tor Vergata,” Rome, Italy;</nlm:aff></affiliation></author><author><name sortKey="Naoe, Tomoki" sort="Naoe, Tomoki" uniqKey="Naoe T" first="Tomoki" last="Naoe">Tomoki Naoe</name><affiliation><nlm:aff id="aff11">National Hospital Organization Nagoya Medical Center, Nagoya, Japan;</nlm:aff></affiliation></author><author><name sortKey="Niederwieser, Dietger" sort="Niederwieser, Dietger" uniqKey="Niederwieser D" first="Dietger" last="Niederwieser">Dietger Niederwieser</name><affiliation><nlm:aff id="aff12">Department of Hematology, Oncology and Hemostasis, University of Leipzig, Leipzig, Germany;</nlm:aff></affiliation></author><author><name sortKey="Ossenkoppele, Gert J" sort="Ossenkoppele, Gert J" uniqKey="Ossenkoppele G" first="Gert J." last="Ossenkoppele">Gert J. Ossenkoppele</name><affiliation><nlm:aff id="aff13">Department of Haematology, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Sanz, Miguel" sort="Sanz, Miguel" uniqKey="Sanz M" first="Miguel" last="Sanz">Miguel Sanz</name><affiliation><nlm:aff id="aff14">Department of Hematology, University Hospital La Fe, University of Valencia, Valencia, Spain;</nlm:aff></affiliation></author><author><name sortKey="Sierra, Jorge" sort="Sierra, Jorge" uniqKey="Sierra J" first="Jorge" last="Sierra">Jorge Sierra</name><affiliation><nlm:aff id="aff15">Hematology Department, Hospital de la Santa Creu i Sant Pau, Jose Carreras Leukemia Research Institute, Barcelona, Spain;</nlm:aff></affiliation></author><author><name sortKey="Tallman, Martin S" sort="Tallman, Martin S" uniqKey="Tallman M" first="Martin S." last="Tallman">Martin S. Tallman</name><affiliation><nlm:aff id="aff10">Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY;</nlm:aff></affiliation></author><author><name sortKey="Tien, Hwei Fang" sort="Tien, Hwei Fang" uniqKey="Tien H" first="Hwei-Fang" last="Tien">Hwei-Fang Tien</name><affiliation><nlm:aff id="aff16">Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan;</nlm:aff></affiliation></author><author><name sortKey="Wei, Andrew H" sort="Wei, Andrew H" uniqKey="Wei A" first="Andrew H." last="Wei">Andrew H. Wei</name><affiliation><nlm:aff id="aff17">Department of Clinical Hematology, The Alfred Hospital, Melbourne, Australia;</nlm:aff></affiliation><affiliation><nlm:aff id="aff18">Australian Centre for Blood Diseases, Monash University, Melbourne, Australia;</nlm:aff></affiliation></author><author><name sortKey="Lowenberg, Bob" sort="Lowenberg, Bob" uniqKey="Lowenberg B" first="Bob" last="Löwenberg">Bob Löwenberg</name><affiliation><nlm:aff wicri:cut="; and" id="aff19">Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Bloomfield, Clara D" sort="Bloomfield, Clara D" uniqKey="Bloomfield C" first="Clara D." last="Bloomfield">Clara D. Bloomfield</name><affiliation><nlm:aff id="aff20">The Ohio State University Comprehensive Cancer Center, Columbus, OH</nlm:aff></affiliation></author></analytic><series><title level="j">Blood</title><idno type="ISSN">0006-4971</idno><idno type="eISSN">1528-0020</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The first edition of the European LeukemiaNet (ELN) recommendations for diagnosis and management of acute myeloid leukemia (AML) in adults, published in 2010, has found broad acceptance by physicians and investigators caring for patients with AML. Recent advances, for example, in the discovery of the genomic landscape of the disease, in the development of assays for genetic testing and for detecting minimal residual disease (MRD), as well as in the development of novel antileukemic agents, prompted an international panel to provide updated evidence- and expert opinion-based recommendations. The recommendations include a revised version of the ELN genetic categories, a proposal for a response category based on MRD status, and criteria for progressive disease.</p></div></front></TEI><pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Blood</journal-id><journal-id journal-id-type="iso-abbrev">Blood</journal-id><journal-id journal-id-type="hwp">bloodjournal</journal-id><journal-id journal-id-type="pmc">blood</journal-id><journal-id journal-id-type="publisher-id">Blood</journal-id><journal-title-group><journal-title>Blood</journal-title></journal-title-group><issn pub-type="ppub">0006-4971</issn><issn pub-type="epub">1528-0020</issn><publisher><publisher-name>American Society of Hematology</publisher-name><publisher-loc>Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27895058</article-id><article-id pub-id-type="pmc">5291965</article-id><article-id pub-id-type="publisher-id">2016/733196</article-id><article-id pub-id-type="doi">10.1182/blood-2016-08-733196</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>5</subject><subject>29</subject><subject>8</subject><subject>33</subject></subj-group><subj-group subj-group-type="heading"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title>Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Döhner</surname><given-names>Hartmut</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Estey</surname><given-names>Elihu</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Grimwade</surname><given-names>David</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Amadori</surname><given-names>Sergio</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Appelbaum</surname><given-names>Frederick R.</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Büchner</surname><given-names>Thomas</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Dombret</surname><given-names>Hervé</given-names></name><xref ref-type="aff" rid="aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Ebert</surname><given-names>Benjamin L.</given-names></name><xref ref-type="aff" rid="aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Fenaux</surname><given-names>Pierre</given-names></name><xref ref-type="aff" rid="aff8">8</xref></contrib><contrib contrib-type="author"><name><surname>Larson</surname><given-names>Richard A.</given-names></name><xref ref-type="aff" rid="aff9">9</xref></contrib><contrib contrib-type="author"><name><surname>Levine</surname><given-names>Ross L.</given-names></name><xref ref-type="aff" rid="aff10">10</xref></contrib><contrib contrib-type="author"><name><surname>Lo-Coco</surname><given-names>Francesco</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Naoe</surname><given-names>Tomoki</given-names></name><xref ref-type="aff" rid="aff11">11</xref></contrib><contrib contrib-type="author"><name><surname>Niederwieser</surname><given-names>Dietger</given-names></name><xref ref-type="aff" rid="aff12">12</xref></contrib><contrib contrib-type="author"><name><surname>Ossenkoppele</surname><given-names>Gert J.</given-names></name><xref ref-type="aff" rid="aff13">13</xref></contrib><contrib contrib-type="author"><name><surname>Sanz</surname><given-names>Miguel</given-names></name><xref ref-type="aff" rid="aff14">14</xref></contrib><contrib contrib-type="author"><name><surname>Sierra</surname><given-names>Jorge</given-names></name><xref ref-type="aff" rid="aff15">15</xref></contrib><contrib contrib-type="author"><name><surname>Tallman</surname><given-names>Martin S.</given-names></name><xref ref-type="aff" rid="aff10">10</xref></contrib><contrib contrib-type="author"><name><surname>Tien</surname><given-names>Hwei-Fang</given-names></name><xref ref-type="aff" rid="aff16">16</xref></contrib><contrib contrib-type="author"><name><surname>Wei</surname><given-names>Andrew H.</given-names></name><xref ref-type="aff" rid="aff17">17</xref><xref ref-type="aff" rid="aff18">18</xref></contrib><contrib contrib-type="author"><name><surname>Löwenberg</surname><given-names>Bob</given-names></name><xref ref-type="aff" rid="aff19">19</xref></contrib><contrib contrib-type="author"><name><surname>Bloomfield</surname><given-names>Clara D.</given-names></name><xref ref-type="aff" rid="aff20">20</xref></contrib><aff id="aff1"><label>1</label>Department of Internal Medicine III, University of Ulm, Ulm, Germany;</aff><aff id="aff2"><label>2</label>Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;</aff><aff id="aff3"><label>3</label>Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom;</aff><aff id="aff4"><label>4</label>Department of Biomedicine and Prevention, Università di Roma “Tor Vergata,” Rome, Italy;</aff><aff id="aff5"><label>5</label>Department of Hematology/Oncology, University of Münster, Münster, Germany;</aff><aff id="aff6"><label>6</label>Institut Universitaire d’Hématologie, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France;</aff><aff id="aff7"><label>7</label>Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA;</aff><aff id="aff8"><label>8</label>Service d’Hématologie, Hôpital Saint-Louis, Paris, France;</aff><aff id="aff9"><label>9</label>Department of Medicine, University of Chicago, Chicago, IL;</aff><aff id="aff10"><label>10</label>Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY;</aff><aff id="aff11"><label>11</label>National Hospital Organization Nagoya Medical Center, Nagoya, Japan;</aff><aff id="aff12"><label>12</label>Department of Hematology, Oncology and Hemostasis, University of Leipzig, Leipzig, Germany;</aff><aff id="aff13"><label>13</label>Department of Haematology, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands;</aff><aff id="aff14"><label>14</label>Department of Hematology, University Hospital La Fe, University of Valencia, Valencia, Spain;</aff><aff id="aff15"><label>15</label>Hematology Department, Hospital de la Santa Creu i Sant Pau, Jose Carreras Leukemia Research Institute, Barcelona, Spain;</aff><aff id="aff16"><label>16</label>Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan;</aff><aff id="aff17"><label>17</label>Department of Clinical Hematology, The Alfred Hospital, Melbourne, Australia;</aff><aff id="aff18"><label>18</label>Australian Centre for Blood Diseases, Monash University, Melbourne, Australia;</aff><aff id="aff19"><label>19</label>Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands; and</aff><aff id="aff20"><label>20</label>The Ohio State University Comprehensive Cancer Center, Columbus, OH</aff></contrib-group><pub-date pub-type="ppub"><day>26</day><month>1</month><year>2017</year></pub-date><pub-date pub-type="epreprint"><day>28</day><month>11</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>26</day><month>1</month><year>2017</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>129</volume><issue>4</issue><fpage>424</fpage><lpage>447</lpage><history><date date-type="received"><day>12</day><month>8</month><year>2016</year></date><date date-type="accepted"><day>15</day><month>11</month><year>2016</year></date></history><permissions><copyright-statement>© 2017 by The American Society of Hematology</copyright-statement><copyright-year>2017</copyright-year></permissions><self-uri xlink:title="pdf" xlink:href="blood733196.pdf"></self-uri><abstract><p>The first edition of the European LeukemiaNet (ELN) recommendations for diagnosis and management of acute myeloid leukemia (AML) in adults, published in 2010, has found broad acceptance by physicians and investigators caring for patients with AML. Recent advances, for example, in the discovery of the genomic landscape of the disease, in the development of assays for genetic testing and for detecting minimal residual disease (MRD), as well as in the development of novel antileukemic agents, prompted an international panel to provide updated evidence- and expert opinion-based recommendations. The recommendations include a revised version of the ELN genetic categories, a proposal for a response category based on MRD status, and criteria for progressive disease.</p></abstract><counts><page-count count="24"></page-count></counts><custom-meta-group><custom-meta><meta-name>access</meta-name><meta-value>free</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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