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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Identification of six new susceptibility loci for invasive epithelial ovarian cancer</title><author><name sortKey="Kuchenbaecker, Karoline B" sort="Kuchenbaecker, Karoline B" uniqKey="Kuchenbaecker K" first="Karoline B." last="Kuchenbaecker">Karoline B. Kuchenbaecker</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Ramus, Susan J" sort="Ramus, Susan J" uniqKey="Ramus S" first="Susan J." last="Ramus">Susan J. Ramus</name><affiliation><nlm:aff id="A2">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Tyrer, Jonathan" sort="Tyrer, Jonathan" uniqKey="Tyrer J" first="Jonathan" last="Tyrer">Jonathan Tyrer</name><affiliation><nlm:aff id="A3">Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Lee, Andrew" sort="Lee, Andrew" uniqKey="Lee A" first="Andrew" last="Lee">Andrew Lee</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Shen, Howard C" sort="Shen, Howard C" uniqKey="Shen H" first="Howard C." last="Shen">Howard C. Shen</name><affiliation><nlm:aff id="A2">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="A4">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia</nlm:aff></affiliation></author><author><name sortKey="Lawrenson, Kate" sort="Lawrenson, Kate" uniqKey="Lawrenson K" first="Kate" last="Lawrenson">Kate Lawrenson</name><affiliation><nlm:aff id="A2">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name><affiliation><nlm:aff id="A4">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia</nlm:aff></affiliation></author><author><name sortKey="Lee, Janet M" sort="Lee, Janet M" uniqKey="Lee J" first="Janet M." last="Lee">Janet M. Lee</name><affiliation><nlm:aff id="A2">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Spindler, Tassja J" sort="Spindler, Tassja J" uniqKey="Spindler T" first="Tassja J." last="Spindler">Tassja J. Spindler</name><affiliation><nlm:aff id="A2">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Lin, Yvonne G" sort="Lin, Yvonne G" uniqKey="Lin Y" first="Yvonne G." last="Lin">Yvonne G. Lin</name><affiliation><nlm:aff id="A5">Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Pejovic, Tanja" sort="Pejovic, Tanja" uniqKey="Pejovic T" first="Tanja" last="Pejovic">Tanja Pejovic</name><affiliation><nlm:aff id="A6">Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Knight Cancer Institute, Portland, OR, USA</nlm:aff></affiliation></author><author><name sortKey="Bean, Yukie" sort="Bean, Yukie" uniqKey="Bean Y" first="Yukie" last="Bean">Yukie Bean</name><affiliation><nlm:aff id="A6">Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Knight Cancer Institute, Portland, OR, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Qiyuan" sort="Li, Qiyuan" uniqKey="Li Q" first="Qiyuan" last="Li">Qiyuan Li</name><affiliation><nlm:aff id="A8">Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Coetzee, Simon" sort="Coetzee, Simon" uniqKey="Coetzee S" first="Simon" last="Coetzee">Simon Coetzee</name><affiliation><nlm:aff id="A9">Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Brazil</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Center For Cell Based Therapy, Monte Alegre, Ribeirão Preto, SP, Brazil</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Center for Integrative Systems Biology, Monte Alegre, Ribeirão Preto, SP, Brazil</nlm:aff></affiliation></author><author><name sortKey="Hazelett, Dennis" sort="Hazelett, Dennis" uniqKey="Hazelett D" first="Dennis" last="Hazelett">Dennis Hazelett</name><affiliation><nlm:aff id="A12">Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Department of Urology, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Miron, Alexander" sort="Miron, Alexander" uniqKey="Miron A" first="Alexander" last="Miron">Alexander Miron</name><affiliation><nlm:aff id="A14">Department of Genomics and Genome Sciences, Case Western Reserve University Medical School, Cleveland, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa" sort="Southey, Melissa" uniqKey="Southey M" first="Melissa" last="Southey">Melissa Southey</name><affiliation><nlm:aff id="A15">Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, VIC, Australia</nlm:aff></affiliation></author><author><name sortKey="Terry, Mary Beth" sort="Terry, Mary Beth" uniqKey="Terry M" first="Mary Beth" last="Terry">Mary Beth Terry</name><affiliation><nlm:aff id="A16">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E." last="Goldgar">David E. Goldgar</name><affiliation><nlm:aff id="A17">Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA</nlm:aff></affiliation></author><author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S." last="Buys">Saundra S. Buys</name><affiliation><nlm:aff id="A18">Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, USA</nlm:aff></affiliation></author><author><name sortKey="Janavicius, Ramunas" sort="Janavicius, Ramunas" uniqKey="Janavicius R" first="Ramunas" last="Janavicius">Ramunas Janavicius</name><affiliation><nlm:aff id="A19">Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius, Lithuania</nlm:aff></affiliation><affiliation><nlm:aff id="A20">State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania</nlm:aff></affiliation></author><author><name sortKey="Dorfling, Cecilia M" sort="Dorfling, Cecilia M" uniqKey="Dorfling C" first="Cecilia M." last="Dorfling">Cecilia M. Dorfling</name><affiliation><nlm:aff id="A21">Department of Genetics, University of Pretoria, Pretoria, South Africa</nlm:aff></affiliation></author><author><name sortKey="Van Rensburg, Elizabeth J" sort="Van Rensburg, Elizabeth J" uniqKey="Van Rensburg E" first="Elizabeth J." last="Van Rensburg">Elizabeth J. Van Rensburg</name><affiliation><nlm:aff id="A21">Department of Genetics, University of Pretoria, Pretoria, South Africa</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="A22">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Ding, Yuan Chun" sort="Ding, Yuan Chun" uniqKey="Ding Y" first="Yuan Chun" last="Ding">Yuan Chun Ding</name><affiliation><nlm:aff id="A22">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V. O." last="Hansen">Thomas V. O. Hansen</name><affiliation><nlm:aff id="A23">Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="J Nson, Lars" sort="J Nson, Lars" uniqKey="J Nson L" first="Lars" last="J Nson">Lars J Nson</name><affiliation><nlm:aff id="A23">Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Gerdes, Anne Marie" sort="Gerdes, Anne Marie" uniqKey="Gerdes A" first="Anne-Marie" last="Gerdes">Anne-Marie Gerdes</name><affiliation><nlm:aff id="A24">Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Ejlertsen, Bent" sort="Ejlertsen, Bent" uniqKey="Ejlertsen B" first="Bent" last="Ejlertsen">Bent Ejlertsen</name><affiliation><nlm:aff id="A25">Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Barrowdale, Daniel" sort="Barrowdale, Daniel" uniqKey="Barrowdale D" first="Daniel" last="Barrowdale">Daniel Barrowdale</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="A26">Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Genotyping Unit (CeGen), Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name><affiliation><nlm:aff id="A26">Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Garcia, Maria Jose" sort="Garcia, Maria Jose" uniqKey="Garcia M" first="Maria Jose" last="Garcia">Maria Jose Garcia</name><affiliation><nlm:aff id="A26">Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Komenaka, Ian" sort="Komenaka, Ian" uniqKey="Komenaka I" first="Ian" last="Komenaka">Ian Komenaka</name><affiliation><nlm:aff id="A29">Maricopa Medical Center, care of City of Hope Clinical Cancer Genetics Community Research Network, Duarte, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Weitzel, Jeffrey N" sort="Weitzel, Jeffrey N" uniqKey="Weitzel J" first="Jeffrey N." last="Weitzel">Jeffrey N. Weitzel</name><affiliation><nlm:aff id="A30">Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network, Duarte, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Ganschow, Pamela" sort="Ganschow, Pamela" uniqKey="Ganschow P" first="Pamela" last="Ganschow">Pamela Ganschow</name><affiliation><nlm:aff id="A31">Cook County Health and Hospital System, care of City of Hope Clinical Cancer Genetics Community Research Network, Duarte, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A32">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Bernard, Loris" sort="Bernard, Loris" uniqKey="Bernard L" first="Loris" last="Bernard">Loris Bernard</name><affiliation><nlm:aff id="A33">Department of Experimental Oncology, Istituto Europeo di Oncologia, Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Cogentech Cancer Genetic Test Laboratory, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Viel, Alessandra" sort="Viel, Alessandra" uniqKey="Viel A" first="Alessandra" last="Viel">Alessandra Viel</name><affiliation><nlm:aff id="A35">Division of Experimental Oncology, CRO Aviano National Cancer Institute, Aviano (PN), Italy</nlm:aff></affiliation></author><author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name><affiliation><nlm:aff id="A36">Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Peissel, Bernard" sort="Peissel, Bernard" uniqKey="Peissel B" first="Bernard" last="Peissel">Bernard Peissel</name><affiliation><nlm:aff id="A37">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="A37">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="A38">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Papi, Laura" sort="Papi, Laura" uniqKey="Papi L" first="Laura" last="Papi">Laura Papi</name><affiliation><nlm:aff id="A39">Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Ottini, Laura" sort="Ottini, Laura" uniqKey="Ottini L" first="Laura" last="Ottini">Laura Ottini</name><affiliation><nlm:aff id="A40">Department of Molecular Medicine, University La Sapienza, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Fostira, Florentia" sort="Fostira, Florentia" uniqKey="Fostira F" first="Florentia" last="Fostira">Florentia Fostira</name><affiliation><nlm:aff id="A41">Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research "Demokritos", Aghia Paraskevi Attikis, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Konstantopoulou, Irene" sort="Konstantopoulou, Irene" uniqKey="Konstantopoulou I" first="Irene" last="Konstantopoulou">Irene Konstantopoulou</name><affiliation><nlm:aff id="A41">Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research "Demokritos", Aghia Paraskevi Attikis, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Garber, Judy" sort="Garber, Judy" uniqKey="Garber J" first="Judy" last="Garber">Judy Garber</name><affiliation><nlm:aff id="A42">Cancer Risk and Prevention Clinic, Dana Farber Cancer Institute, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Perkins, Jo" sort="Perkins, Jo" uniqKey="Perkins J" first="Jo" last="Perkins">Jo Perkins</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Platte, Radka" sort="Platte, Radka" uniqKey="Platte R" first="Radka" last="Platte">Radka Platte</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Ellis, Steve" sort="Ellis, Steve" uniqKey="Ellis S" first="Steve" last="Ellis">Steve Ellis</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name><affiliation><nlm:aff id="A43">Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita Katharina" sort="Schmutzler, Rita Katharina" uniqKey="Schmutzler R" first="Rita Katharina" last="Schmutzler">Rita Katharina Schmutzler</name><affiliation><nlm:aff id="A44">Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A45">Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A46">Center for Molecular Medicine Cologne (CMMC), University of Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A47">Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name><affiliation><nlm:aff id="A48">Institute for Medical Informatics, Statistics and Epidemiology University of Leipzig, Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name><affiliation><nlm:aff id="A49">University Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name><affiliation><nlm:aff id="A50">INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A51">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon – Centre Léon Bérard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Damiola, Francesca" sort="Damiola, Francesca" uniqKey="Damiola F" first="Francesca" last="Damiola">Francesca Damiola</name><affiliation><nlm:aff id="A50">INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name><affiliation><nlm:aff id="A50">INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation><nlm:aff id="A52">Institut Curie, Department of Tumour Biology, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A53">Institut Curie, INSERM U830, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Université Paris Descartes, Sorbonne Paris Cité, France</nlm:aff></affiliation></author><author><name sortKey="Claes, Kathleen" sort="Claes, Kathleen" uniqKey="Claes K" first="Kathleen" last="Claes">Kathleen Claes</name><affiliation><nlm:aff id="A55">Center for Medical Genetics, Ghent University, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="De Leeneer, Kim" sort="De Leeneer, Kim" uniqKey="De Leeneer K" first="Kim" last="De Leeneer">Kim De Leeneer</name><affiliation><nlm:aff id="A55">Center for Medical Genetics, Ghent University, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="Kirk, Judy" sort="Kirk, Judy" uniqKey="Kirk J" first="Judy" last="Kirk">Judy Kirk</name><affiliation><nlm:aff id="A56">Australia New Zealand Gynecologic Oncology Group (ANZGOG) and Familial Cancer Service, Westmead Hosptial, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Rodriguez, Gustavo C" sort="Rodriguez, Gustavo C" uniqKey="Rodriguez G" first="Gustavo C." last="Rodriguez">Gustavo C. Rodriguez</name><affiliation><nlm:aff id="A57">Division of Gynecologic Oncology, NorthShore University HealthSystem, Evanston, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Piedmonte, Marion" sort="Piedmonte, Marion" uniqKey="Piedmonte M" first="Marion" last="Piedmonte">Marion Piedmonte</name><affiliation><nlm:aff id="A58">Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, NY, USA</nlm:aff></affiliation></author><author><name sortKey="O Malley, David M" sort="O Malley, David M" uniqKey="O Malley D" first="David M." last="O'Malley">David M. O'Malley</name><affiliation><nlm:aff id="A59">James Cancer Center, Ohio State University, Columbus, OH, USA</nlm:aff></affiliation></author><author><name sortKey="De La Hoya, Miguel" sort="De La Hoya, Miguel" uniqKey="De La Hoya M" first="Miguel" last="De La Hoya">Miguel De La Hoya</name><affiliation><nlm:aff id="A60">Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name><affiliation><nlm:aff id="A60">Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="A61">Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A62">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Collee, J Margriet" sort="Collee, J Margriet" uniqKey="Collee J" first="J. Margriet" last="Collée">J. Margriet Collée</name><affiliation><nlm:aff id="A63">Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Rookus, Matti A" sort="Rookus, Matti A" uniqKey="Rookus M" first="Matti A." last="Rookus">Matti A. Rookus</name><affiliation><nlm:aff id="A64">Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Oosterwijk, Jan C" sort="Oosterwijk, Jan C" uniqKey="Oosterwijk J" first="Jan C." last="Oosterwijk">Jan C. Oosterwijk</name><affiliation><nlm:aff id="A65">Department of Genetics, University Medical Center, Groningen University, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Tihomirova, Laima" sort="Tihomirova, Laima" uniqKey="Tihomirova L" first="Laima" last="Tihomirova">Laima Tihomirova</name><affiliation><nlm:aff id="A66">Latvian Biomedical Research and Study Centre, Riga, Latvia</nlm:aff></affiliation></author><author><name sortKey="Tung, Nadine" sort="Tung, Nadine" uniqKey="Tung N" first="Nadine" last="Tung">Nadine Tung</name><affiliation><nlm:aff id="A67">Department of Medical Oncology, Beth Israel Deaconess Medical Center</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="A68">Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name><affiliation><nlm:aff id="A69">Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, USA</nlm:aff></affiliation></author><author><name sortKey="Tischkowitz, Marc" sort="Tischkowitz, Marc" uniqKey="Tischkowitz M" first="Marc" last="Tischkowitz">Marc Tischkowitz</name><affiliation><nlm:aff id="A70">Program in Cancer Genetics, McGill University, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Imyanitov, Evgeny N" sort="Imyanitov, Evgeny N" uniqKey="Imyanitov E" first="Evgeny N." last="Imyanitov">Evgeny N. Imyanitov</name><affiliation><nlm:aff id="A71">N.N. Petrov Institute of Oncology, St.Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A." last="Caligo">Maria A. Caligo</name><affiliation><nlm:aff id="A72">Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, Pisa, Italy</nlm:aff></affiliation></author><author><name sortKey="Campbell, Ian" sort="Campbell, Ian" uniqKey="Campbell I" first="Ian" last="Campbell">Ian Campbell</name><affiliation><nlm:aff id="A73">VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B. L." last="Hogervorst">Frans B. L. Hogervorst</name><affiliation><nlm:aff id="A74">Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name><affiliation><nlm:aff id="A75">Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary</nlm:aff></affiliation></author><author><name sortKey="Diez, Orland" sort="Diez, Orland" uniqKey="Diez O" first="Orland" last="Diez">Orland Diez</name><affiliation><nlm:aff id="A76">Oncogenetics Group, University Hospital Vall d’Hebron, Vall d’Hebron Institute of Oncology (VHIO) and Universitat Autònoma de Barcelona; Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Blanco, Ignacio" sort="Blanco, Ignacio" uniqKey="Blanco I" first="Ignacio" last="Blanco">Ignacio Blanco</name><affiliation><nlm:aff id="A77">Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Brunet, Joan" sort="Brunet, Joan" uniqKey="Brunet J" first="Joan" last="Brunet">Joan Brunet</name><affiliation><nlm:aff id="A78">Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI-Catalan Institute of Oncology, Girona, Spain</nlm:aff></affiliation></author><author><name sortKey="Lazaro, Conxi" sort="Lazaro, Conxi" uniqKey="Lazaro C" first="Conxi" last="Lazaro">Conxi Lazaro</name><affiliation><nlm:aff id="A79">Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Pujana, Miquel Angel" sort="Pujana, Miquel Angel" uniqKey="Pujana M" first="Miquel Angel" last="Pujana">Miquel Angel Pujana</name><affiliation><nlm:aff id="A80">Breast Cancer and Systems Biology Unit, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="A81">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name><affiliation><nlm:aff id="A81">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="A81">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Sukiennicki, Grzegorz" sort="Sukiennicki, Grzegorz" uniqKey="Sukiennicki G" first="Grzegorz" last="Sukiennicki">Grzegorz Sukiennicki</name><affiliation><nlm:aff id="A81">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Barkardottir, Rosa B" sort="Barkardottir, Rosa B" uniqKey="Barkardottir R" first="Rosa B." last="Barkardottir">Rosa B. Barkardottir</name><affiliation><nlm:aff id="A82">Department of Pathology, Landspitali University Hospital and BMC, Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Plante, Marie" sort="Plante, Marie" uniqKey="Plante M" first="Marie" last="Plante">Marie Plante</name><affiliation><nlm:aff id="A83">Gynaecologic Oncology Service, Centre Hospitalier Universitaire de Québec (CHUQ), Québec, Canada</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="A84">Centre Hospitalier Universitaire de Québec Research Center, Laval University, Quebec City, Canada</nlm:aff></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation><nlm:aff id="A84">Centre Hospitalier Universitaire de Québec Research Center, Laval University, Quebec City, Canada</nlm:aff></affiliation></author><author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name><affiliation><nlm:aff id="A85">Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Tognazzo, Silvia" sort="Tognazzo, Silvia" uniqKey="Tognazzo S" first="Silvia" last="Tognazzo">Silvia Tognazzo</name><affiliation><nlm:aff id="A85">Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Teixeira, Manuel R" sort="Teixeira, Manuel R" uniqKey="Teixeira M" first="Manuel R." last="Teixeira">Manuel R. Teixeira</name><affiliation><nlm:aff id="A86">Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Department of Genetics, Portuguese Oncology Institute, Porto, Portugal</nlm:aff></affiliation></author><author><name sortKey="Pankratz, Vernon S" sort="Pankratz, Vernon S" uniqKey="Pankratz V" first="Vernon S." last="Pankratz">Vernon S. Pankratz</name><affiliation><nlm:aff id="A88">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff id="A89">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Lindor, Noralane" sort="Lindor, Noralane" uniqKey="Lindor N" first="Noralane" last="Lindor">Noralane Lindor</name><affiliation><nlm:aff id="A88">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I." last="Szabo">Csilla I. Szabo</name><affiliation><nlm:aff id="A90">National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Kauff, Noah" sort="Kauff, Noah" uniqKey="Kauff N" first="Noah" last="Kauff">Noah Kauff</name><affiliation><nlm:aff id="A91">Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name><affiliation><nlm:aff id="A91">Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Aghajanian, Carol A" sort="Aghajanian, Carol A" uniqKey="Aghajanian C" first="Carol A." last="Aghajanian">Carol A. Aghajanian</name><affiliation><nlm:aff id="A91">Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Pfeiler, Georg" sort="Pfeiler, Georg" uniqKey="Pfeiler G" first="Georg" last="Pfeiler">Georg Pfeiler</name><affiliation><nlm:aff id="A92">Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Berger, Andreas" sort="Berger, Andreas" uniqKey="Berger A" first="Andreas" last="Berger">Andreas Berger</name><affiliation><nlm:aff id="A92">Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Singer, Christian F" sort="Singer, Christian F" uniqKey="Singer C" first="Christian F." last="Singer">Christian F. Singer</name><affiliation><nlm:aff id="A92">Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Tea, Muy Kheng" sort="Tea, Muy Kheng" uniqKey="Tea M" first="Muy-Kheng" last="Tea">Muy-Kheng Tea</name><affiliation><nlm:aff id="A92">Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Phelan, Catherine M" sort="Phelan, Catherine M" uniqKey="Phelan C" first="Catherine M." last="Phelan">Catherine M. Phelan</name><affiliation><nlm:aff id="A93">Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><affiliation><nlm:aff id="A94">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L." last="Mai">Phuong L. Mai</name><affiliation><nlm:aff id="A94">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation><nlm:aff id="A95">Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel</nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="A96">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A97">Laboratory Medicine Program, University Health Network, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Tchatchou, Sandrine" sort="Tchatchou, Sandrine" uniqKey="Tchatchou S" first="Sandrine" last="Tchatchou">Sandrine Tchatchou</name><affiliation><nlm:aff id="A98">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A96">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A99">Department of Molecular Genetics, University of Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="A98">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda Ewart" sort="Toland, Amanda Ewart" uniqKey="Toland A" first="Amanda Ewart" last="Toland">Amanda Ewart Toland</name><affiliation><nlm:aff id="A100">Department of Molecular Virology, Immunology and Medical Genetics, Columbus, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Jensen, Uffe Birk" sort="Jensen, Uffe Birk" uniqKey="Jensen U" first="Uffe Birk" last="Jensen">Uffe Birk Jensen</name><affiliation><nlm:aff id="A101">Department of Clinical Genetics, Aarhus University Hospital, Aarhus N, Denmark</nlm:aff></affiliation></author><author><name sortKey="Kruse, Torben A" sort="Kruse, Torben A" uniqKey="Kruse T" first="Torben A." last="Kruse">Torben A. Kruse</name><affiliation><nlm:aff id="A102">Department of Clinical Genetics, Odense University Hospital, Odense C, Denmark</nlm:aff></affiliation></author><author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name><affiliation><nlm:aff id="A102">Department of Clinical Genetics, Odense University Hospital, Odense C, Denmark</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Anders" sort="Bojesen, Anders" uniqKey="Bojesen A" first="Anders" last="Bojesen">Anders Bojesen</name><affiliation><nlm:aff id="A103">Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark</nlm:aff></affiliation></author><author><name sortKey="Zidan, Jamal" sort="Zidan, Jamal" uniqKey="Zidan J" first="Jamal" last="Zidan">Jamal Zidan</name><affiliation><nlm:aff id="A104">Institute of Oncology, Rivka Ziv Medical Center, Zefat, Israel</nlm:aff></affiliation></author><author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><affiliation><nlm:aff id="A105">Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel Aviv, Israel</nlm:aff></affiliation></author><author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name><affiliation><nlm:aff id="A105">Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel Aviv, Israel</nlm:aff></affiliation></author><author><name sortKey="Soller, Maria" sort="Soller, Maria" uniqKey="Soller M" first="Maria" last="Soller">Maria Soller</name><affiliation><nlm:aff id="A106">Department of Clinical Genetics, Lund University Hospital, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Liljegren, Annelie" sort="Liljegren, Annelie" uniqKey="Liljegren A" first="Annelie" last="Liljegren">Annelie Liljegren</name><affiliation><nlm:aff id="A107">Department of Oncology, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Arver, Brita" sort="Arver, Brita" uniqKey="Arver B" first="Brita" last="Arver">Brita Arver</name><affiliation><nlm:aff id="A107">Department of Oncology, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Einbeigi, Zakaria" sort="Einbeigi, Zakaria" uniqKey="Einbeigi Z" first="Zakaria" last="Einbeigi">Zakaria Einbeigi</name><affiliation><nlm:aff id="A108">Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Stenmark Askmalm, Marie" sort="Stenmark Askmalm, Marie" uniqKey="Stenmark Askmalm M" first="Marie" last="Stenmark-Askmalm">Marie Stenmark-Askmalm</name><affiliation><nlm:aff id="A109">Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden</nlm:aff></affiliation></author><author><name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I." last="Olopade">Olufunmilayo I. Olopade</name><affiliation><nlm:aff id="A110">Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, USA</nlm:aff></affiliation></author><author><name sortKey="Nussbaum, Robert L" sort="Nussbaum, Robert L" uniqKey="Nussbaum R" first="Robert L." last="Nussbaum">Robert L. Nussbaum</name><affiliation><nlm:aff id="A111">Department of Medicine and Genetics, University of California, San Francisco, USA</nlm:aff></affiliation></author><author><name sortKey="Rebbeck, Timothy R" sort="Rebbeck, Timothy R" uniqKey="Rebbeck T" first="Timothy R." last="Rebbeck">Timothy R. Rebbeck</name><affiliation><nlm:aff id="A112">Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><affiliation><nlm:aff id="A112">Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M." last="Domchek">Susan M. Domchek</name><affiliation><nlm:aff id="A112">Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Lu, Karen H" sort="Lu, Karen H" uniqKey="Lu K" first="Karen H." last="Lu">Karen H. Lu</name><affiliation><nlm:aff id="A113">Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y." last="Karlan">Beth Y. Karlan</name><affiliation><nlm:aff id="A114">Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Walsh, Christine" sort="Walsh, Christine" uniqKey="Walsh C" first="Christine" last="Walsh">Christine Walsh</name><affiliation><nlm:aff id="A114">Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Lester, Jenny" sort="Lester, Jenny" uniqKey="Lester J" first="Jenny" last="Lester">Jenny Lester</name><affiliation><nlm:aff id="A114">Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Hein, Alexander" sort="Hein, Alexander" uniqKey="Hein A" first="Alexander" last="Hein">Alexander Hein</name><affiliation><nlm:aff id="A115">Department of Obstetrics and Gynecology, Erlangen University Hospital, University of Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="A116">Institute of Human Genetics, University of Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="A115">Department of Obstetrics and Gynecology, Erlangen University Hospital, University of Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="A115">Department of Obstetrics and Gynecology, Erlangen University Hospital, University of Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A117">University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="A118">Vesalius Research Center, VIB, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A119">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Nieuwenhuysen, Els Van" sort="Nieuwenhuysen, Els Van" uniqKey="Nieuwenhuysen E" first="Els Van" last="Nieuwenhuysen">Els Van Nieuwenhuysen</name><affiliation><nlm:aff id="A120">Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Vergote, Ignace" sort="Vergote, Ignace" uniqKey="Vergote I" first="Ignace" last="Vergote">Ignace Vergote</name><affiliation><nlm:aff id="A120">Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Sandrina" sort="Lambrechts, Sandrina" uniqKey="Lambrechts S" first="Sandrina" last="Lambrechts">Sandrina Lambrechts</name><affiliation><nlm:aff id="A120">Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Dicks, Ed" sort="Dicks, Ed" uniqKey="Dicks E" first="Ed" last="Dicks">Ed Dicks</name><affiliation><nlm:aff id="A3">Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Doherty, Jennifer A" sort="Doherty, Jennifer A" uniqKey="Doherty J" first="Jennifer A." last="Doherty">Jennifer A. Doherty</name><affiliation><nlm:aff id="A121">Department of Community and Family Medicine, Section of Biostatistics & Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA</nlm:aff></affiliation></author><author><name sortKey="Wicklund, Kristine G" sort="Wicklund, Kristine G" uniqKey="Wicklund K" first="Kristine G." last="Wicklund">Kristine G. Wicklund</name><affiliation><nlm:aff id="A122">Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Rossing, Mary Anne" sort="Rossing, Mary Anne" uniqKey="Rossing M" first="Mary Anne" last="Rossing">Mary Anne Rossing</name><affiliation><nlm:aff id="A122">Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A123">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="A124">German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A124">German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name><affiliation><nlm:aff id="A125">Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Eilber, Ursula" sort="Eilber, Ursula" uniqKey="Eilber U" first="Ursula" last="Eilber">Ursula Eilber</name><affiliation><nlm:aff id="A124">German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Moysich, Kirsten B" sort="Moysich, Kirsten B" uniqKey="Moysich K" first="Kirsten B." last="Moysich">Kirsten B. Moysich</name><affiliation><nlm:aff id="A126">Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Odunsi, Kunle" sort="Odunsi, Kunle" uniqKey="Odunsi K" first="Kunle" last="Odunsi">Kunle Odunsi</name><affiliation><nlm:aff id="A127">Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Sucheston Campbell, Lara" sort="Sucheston Campbell, Lara" uniqKey="Sucheston Campbell L" first="Lara" last="Sucheston-Campbell">Lara Sucheston-Campbell</name><affiliation><nlm:aff id="A126">Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Lele, Shashi" sort="Lele, Shashi" uniqKey="Lele S" first="Shashi" last="Lele">Shashi Lele</name><affiliation><nlm:aff id="A126">Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Wilkens, Lynne R" sort="Wilkens, Lynne R" uniqKey="Wilkens L" first="Lynne R." last="Wilkens">Lynne R. Wilkens</name><affiliation><nlm:aff id="A128">Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, USA</nlm:aff></affiliation></author><author><name sortKey="Goodman, Marc T" sort="Goodman, Marc T" uniqKey="Goodman M" first="Marc T." last="Goodman">Marc T. Goodman</name><affiliation><nlm:aff id="A129">Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A130">Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Thompson, Pamela J" sort="Thompson, Pamela J" uniqKey="Thompson P" first="Pamela J." last="Thompson">Pamela J. Thompson</name><affiliation><nlm:aff id="A129">Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A130">Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Shvetsov, Yurii B" sort="Shvetsov, Yurii B" uniqKey="Shvetsov Y" first="Yurii B." last="Shvetsov">Yurii B. Shvetsov</name><affiliation><nlm:aff id="A128">Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, USA</nlm:aff></affiliation></author><author><name sortKey="Runnebaum, Ingo B" sort="Runnebaum, Ingo B" uniqKey="Runnebaum I" first="Ingo B." last="Runnebaum">Ingo B. Runnebaum</name><affiliation><nlm:aff id="A131">Department of Gynecology, Jena University Hospital - Friedrich Schiller University, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Durst, Matthias" sort="Durst, Matthias" uniqKey="Durst M" first="Matthias" last="Dürst">Matthias Dürst</name><affiliation><nlm:aff id="A131">Department of Gynecology, Jena University Hospital - Friedrich Schiller University, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Hillemanns, Peter" sort="Hillemanns, Peter" uniqKey="Hillemanns P" first="Peter" last="Hillemanns">Peter Hillemanns</name><affiliation><nlm:aff id="A132">Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="A133">Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Antonenkova, Natalia" sort="Antonenkova, Natalia" uniqKey="Antonenkova N" first="Natalia" last="Antonenkova">Natalia Antonenkova</name><affiliation><nlm:aff id="A134">Byelorussian Institute for Oncology and Medical Radiology Aleksandrov N.N., Minsk, Belarus</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia" sort="Bogdanova, Natalia" uniqKey="Bogdanova N" first="Natalia" last="Bogdanova">Natalia Bogdanova</name><affiliation><nlm:aff id="A133">Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Leminen, Arto" sort="Leminen, Arto" uniqKey="Leminen A" first="Arto" last="Leminen">Arto Leminen</name><affiliation><nlm:aff id="A62">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Pelttari, Liisa M" sort="Pelttari, Liisa M" uniqKey="Pelttari L" first="Liisa M." last="Pelttari">Liisa M. Pelttari</name><affiliation><nlm:aff id="A62">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Butzow, Ralf" sort="Butzow, Ralf" uniqKey="Butzow R" first="Ralf" last="Butzow">Ralf Butzow</name><affiliation><nlm:aff id="A62">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A135">Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Modugno, Francesmary" sort="Modugno, Francesmary" uniqKey="Modugno F" first="Francesmary" last="Modugno">Francesmary Modugno</name><affiliation><nlm:aff id="A136">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A137">Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A138">Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A139">Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Kelley, Joseph L" sort="Kelley, Joseph L" uniqKey="Kelley J" first="Joseph L." last="Kelley">Joseph L. Kelley</name><affiliation><nlm:aff id="A137">Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Edwards, Robert P" sort="Edwards, Robert P" uniqKey="Edwards R" first="Robert P." last="Edwards">Robert P. Edwards</name><affiliation><nlm:aff id="A137">Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A138">Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Ness, Roberta B" sort="Ness, Roberta B" uniqKey="Ness R" first="Roberta B." last="Ness">Roberta B. Ness</name><affiliation><nlm:aff id="A140">The University of Texas School of Public Health, Houston, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Du Bois, Andreas" sort="Du Bois, Andreas" uniqKey="Du Bois A" first="Andreas" last="Du Bois">Andreas Du Bois</name><affiliation><nlm:aff id="A141">Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A142">Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Heitz, Florian" sort="Heitz, Florian" uniqKey="Heitz F" first="Florian" last="Heitz">Florian Heitz</name><affiliation><nlm:aff id="A141">Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A142">Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Schwaab, Ira" sort="Schwaab, Ira" uniqKey="Schwaab I" first="Ira" last="Schwaab">Ira Schwaab</name><affiliation><nlm:aff id="A143">Institut für Humangenetik Wiesbaden, Wiesbaden, Germany</nlm:aff></affiliation></author><author><name sortKey="Harter, Philipp" sort="Harter, Philipp" uniqKey="Harter P" first="Philipp" last="Harter">Philipp Harter</name><affiliation><nlm:aff id="A141">Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A142">Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name><affiliation><nlm:aff id="A144">Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Fukuoka, Japan</nlm:aff></affiliation></author><author><name sortKey="Hosono, Satoyo" sort="Hosono, Satoyo" uniqKey="Hosono S" first="Satoyo" last="Hosono">Satoyo Hosono</name><affiliation><nlm:aff id="A145">Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan</nlm:aff></affiliation></author><author><name sortKey="Orsulic, Sandra" sort="Orsulic, Sandra" uniqKey="Orsulic S" first="Sandra" last="Orsulic">Sandra Orsulic</name><affiliation><nlm:aff id="A114">Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Jensen, Allan" sort="Jensen, Allan" uniqKey="Jensen A" first="Allan" last="Jensen">Allan Jensen</name><affiliation><nlm:aff id="A146">Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Kjaer, Susanne Kruger" sort="Kjaer, Susanne Kruger" uniqKey="Kjaer S" first="Susanne Kruger" last="Kjaer">Susanne Kruger Kjaer</name><affiliation><nlm:aff id="A146">Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A147">Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Hogdall, Estrid" sort="Hogdall, Estrid" uniqKey="Hogdall E" first="Estrid" last="Hogdall">Estrid Hogdall</name><affiliation><nlm:aff id="A146">Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A148">Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Hasmad, Hanis Nazihah" sort="Hasmad, Hanis Nazihah" uniqKey="Hasmad H" first="Hanis Nazihah" last="Hasmad">Hanis Nazihah Hasmad</name><affiliation><nlm:aff id="A149">Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Noor Azmi, Mat Adenan" sort="Noor Azmi, Mat Adenan" uniqKey="Noor Azmi M" first="Mat Adenan" last="Noor Azmi">Mat Adenan Noor Azmi</name><affiliation><nlm:aff id="A150">Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo-Hwang" last="Teo">Soo-Hwang Teo</name><affiliation><nlm:aff id="A149">Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia</nlm:aff></affiliation><affiliation><nlm:aff id="A151">University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Woo, Yin Ling" sort="Woo, Yin Ling" uniqKey="Woo Y" first="Yin-Ling" last="Woo">Yin-Ling Woo</name><affiliation><nlm:aff id="A150">Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia</nlm:aff></affiliation><affiliation><nlm:aff id="A151">University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Fridley, Brooke L" sort="Fridley, Brooke L" uniqKey="Fridley B" first="Brooke L." last="Fridley">Brooke L. Fridley</name><affiliation><nlm:aff id="A152">Biostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, KS, USA</nlm:aff></affiliation></author><author><name sortKey="Goode, Ellen L" sort="Goode, Ellen L" uniqKey="Goode E" first="Ellen L." last="Goode">Ellen L. Goode</name><affiliation><nlm:aff id="A88">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Cunningham, Julie M" sort="Cunningham, Julie M" uniqKey="Cunningham J" first="Julie M." last="Cunningham">Julie M. Cunningham</name><affiliation><nlm:aff id="A89">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Vierkant, Robert A" sort="Vierkant, Robert A" uniqKey="Vierkant R" first="Robert A." last="Vierkant">Robert A. Vierkant</name><affiliation><nlm:aff id="A153">Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Bruinsma, Fiona" sort="Bruinsma, Fiona" uniqKey="Bruinsma F" first="Fiona" last="Bruinsma">Fiona Bruinsma</name><affiliation><nlm:aff id="A154">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="A154">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia</nlm:aff></affiliation></author><author><name sortKey="Liang, Dong" sort="Liang, Dong" uniqKey="Liang D" first="Dong" last="Liang">Dong Liang</name><affiliation><nlm:aff id="A155">College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Hildebrandt, Michelle A T" sort="Hildebrandt, Michelle A T" uniqKey="Hildebrandt M" first="Michelle A. T." last="Hildebrandt">Michelle A. T. Hildebrandt</name><affiliation><nlm:aff id="A156">Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Wu, Xifeng" sort="Wu, Xifeng" uniqKey="Wu X" first="Xifeng" last="Wu">Xifeng Wu</name><affiliation><nlm:aff id="A156">Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Levine, Douglas A" sort="Levine, Douglas A" uniqKey="Levine D" first="Douglas A." last="Levine">Douglas A. Levine</name><affiliation><nlm:aff id="A157">Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Bisogna, Maria" sort="Bisogna, Maria" uniqKey="Bisogna M" first="Maria" last="Bisogna">Maria Bisogna</name><affiliation><nlm:aff id="A157">Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Berchuck, Andrew" sort="Berchuck, Andrew" uniqKey="Berchuck A" first="Andrew" last="Berchuck">Andrew Berchuck</name><affiliation><nlm:aff id="A158">Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Iversen, Edwin S" sort="Iversen, Edwin S" uniqKey="Iversen E" first="Edwin S." last="Iversen">Edwin S. Iversen</name><affiliation><nlm:aff id="A159">Department of Statistical Science, Duke University, Durham, North Carolina, USA</nlm:aff></affiliation></author><author><name sortKey="Schildkraut, Joellen M" sort="Schildkraut, Joellen M" uniqKey="Schildkraut J" first="Joellen M." last="Schildkraut">Joellen M. Schildkraut</name><affiliation><nlm:aff id="A160">Cancer Control and Population Sciences, Duke Cancer Institute, Durham, North Carolina, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A161">Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Concannon, Patrick" sort="Concannon, Patrick" uniqKey="Concannon P" first="Patrick" last="Concannon">Patrick Concannon</name><affiliation><nlm:aff id="A162">Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Fl, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A163">Genetics Institute, University of Florida, Gainesville, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Weber, Rachel Palmieri" sort="Weber, Rachel Palmieri" uniqKey="Weber R" first="Rachel Palmieri" last="Weber">Rachel Palmieri Weber</name><affiliation><nlm:aff id="A161">Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Cramer, Daniel W" sort="Cramer, Daniel W" uniqKey="Cramer D" first="Daniel W." last="Cramer">Daniel W. Cramer</name><affiliation><nlm:aff id="A164">Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A165">Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Terry, Kathryn L" sort="Terry, Kathryn L" uniqKey="Terry K" first="Kathryn L." last="Terry">Kathryn L. Terry</name><affiliation><nlm:aff id="A164">Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A165">Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Poole, Elizabeth M" sort="Poole, Elizabeth M" uniqKey="Poole E" first="Elizabeth M." last="Poole">Elizabeth M. Poole</name><affiliation><nlm:aff id="A166">Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A167">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Tworoger, Shelley S" sort="Tworoger, Shelley S" uniqKey="Tworoger S" first="Shelley S." last="Tworoger">Shelley S. Tworoger</name><affiliation><nlm:aff id="A166">Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A167">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Bandera, Elisa V" sort="Bandera, Elisa V" uniqKey="Bandera E" first="Elisa V." last="Bandera">Elisa V. Bandera</name><affiliation><nlm:aff id="A168">Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA</nlm:aff></affiliation></author><author><name sortKey="Orlow, Irene" sort="Orlow, Irene" uniqKey="Orlow I" first="Irene" last="Orlow">Irene Orlow</name><affiliation><nlm:aff id="A169">Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, Epidemiology Service, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Olson, Sara H" sort="Olson, Sara H" uniqKey="Olson S" first="Sara H." last="Olson">Sara H. Olson</name><affiliation><nlm:aff id="A169">Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, Epidemiology Service, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Krakstad, Camilla" sort="Krakstad, Camilla" uniqKey="Krakstad C" first="Camilla" last="Krakstad">Camilla Krakstad</name><affiliation><nlm:aff id="A170">Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A171">Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway</nlm:aff></affiliation></author><author><name sortKey="Salvesen, Helga B" sort="Salvesen, Helga B" uniqKey="Salvesen H" first="Helga B." last="Salvesen">Helga B. Salvesen</name><affiliation><nlm:aff id="A170">Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A171">Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway</nlm:aff></affiliation></author><author><name sortKey="Tangen, Ingvild L" sort="Tangen, Ingvild L" uniqKey="Tangen I" first="Ingvild L." last="Tangen">Ingvild L. Tangen</name><affiliation><nlm:aff id="A170">Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A171">Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway</nlm:aff></affiliation></author><author><name sortKey="Bjorge, Line" sort="Bjorge, Line" uniqKey="Bjorge L" first="Line" last="Bjorge">Line Bjorge</name><affiliation><nlm:aff id="A170">Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A171">Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway</nlm:aff></affiliation></author><author><name sortKey="Van Altena, Anne M" sort="Van Altena, Anne M" uniqKey="Van Altena A" first="Anne M." last="Van Altena">Anne M. Van Altena</name><affiliation><nlm:aff id="A172">Department of Gynaecology, Radboud University Medical Centre, Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Aben, Katja K H" sort="Aben, Katja K H" uniqKey="Aben K" first="Katja K. H." last="Aben">Katja K. H. Aben</name><affiliation><nlm:aff id="A173">Comprehensive Cancer Center The Netherlands, Utrecht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A174">Department for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kiemeney, Lambertus A" sort="Kiemeney, Lambertus A" uniqKey="Kiemeney L" first="Lambertus A." last="Kiemeney">Lambertus A. Kiemeney</name><affiliation><nlm:aff id="A174">Department for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A175">Department of Urology, Radboud University Medical Centre, Nijmegen, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Massuger, Leon F A G" sort="Massuger, Leon F A G" uniqKey="Massuger L" first="Leon F. A. G." last="Massuger">Leon F. A. G. Massuger</name><affiliation><nlm:aff id="A172">Department of Gynaecology, Radboud University Medical Centre, Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kellar, Melissa" sort="Kellar, Melissa" uniqKey="Kellar M" first="Melissa" last="Kellar">Melissa Kellar</name><affiliation><nlm:aff id="A6">Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Knight Cancer Institute, Portland, OR, USA</nlm:aff></affiliation></author><author><name sortKey="Brooks Wilson, Angela" sort="Brooks Wilson, Angela" uniqKey="Brooks Wilson A" first="Angela" last="Brooks-Wilson">Angela Brooks-Wilson</name><affiliation><nlm:aff id="A176">Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A177">Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC Canada</nlm:aff></affiliation></author><author><name sortKey="Kelemen, Linda E" sort="Kelemen, Linda E" uniqKey="Kelemen L" first="Linda E." last="Kelemen">Linda E. Kelemen</name><affiliation><nlm:aff id="A178">Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, USA</nlm:aff></affiliation></author><author><name sortKey="Cook, Linda S" sort="Cook, Linda S" uniqKey="Cook L" first="Linda S." last="Cook">Linda S. Cook</name><affiliation><nlm:aff id="A179">Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA</nlm:aff></affiliation></author><author><name sortKey="Le, Nhu D" sort="Le, Nhu D" uniqKey="Le N" first="Nhu D." last="Le">Nhu D. Le</name><affiliation><nlm:aff id="A180">Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada</nlm:aff></affiliation></author><author><name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name><affiliation><nlm:aff id="A181">International Hereditary Cancer Center, Department of Genetics and Pathology, Clinic of Opthalmology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Yang, Hannah" sort="Yang, Hannah" uniqKey="Yang H" first="Hannah" last="Yang">Hannah Yang</name><affiliation><nlm:aff id="A182">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation><nlm:aff id="A183">Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Brinton, Louise A" sort="Brinton, Louise A" uniqKey="Brinton L" first="Louise A." last="Brinton">Louise A. Brinton</name><affiliation><nlm:aff id="A182">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Wentzensen, Nicolas" sort="Wentzensen, Nicolas" uniqKey="Wentzensen N" first="Nicolas" last="Wentzensen">Nicolas Wentzensen</name><affiliation><nlm:aff id="A182">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Hogdall, Claus" sort="Hogdall, Claus" uniqKey="Hogdall C" first="Claus" last="Hogdall">Claus Hogdall</name><affiliation><nlm:aff id="A147">Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Lundvall, Lene" sort="Lundvall, Lene" uniqKey="Lundvall L" first="Lene" last="Lundvall">Lene Lundvall</name><affiliation><nlm:aff id="A147">Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nedergaard, Lotte" sort="Nedergaard, Lotte" uniqKey="Nedergaard L" first="Lotte" last="Nedergaard">Lotte Nedergaard</name><affiliation><nlm:aff id="A184">Department of Pathology, Rigshospitalet, University of Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Baker, Helen" sort="Baker, Helen" uniqKey="Baker H" first="Helen" last="Baker">Helen Baker</name><affiliation><nlm:aff id="A3">Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Song, Honglin" sort="Song, Honglin" uniqKey="Song H" first="Honglin" last="Song">Honglin Song</name><affiliation><nlm:aff id="A3">Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Eccles, Diana" sort="Eccles, Diana" uniqKey="Eccles D" first="Diana" last="Eccles">Diana Eccles</name><affiliation><nlm:aff id="A185">Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Mcneish, Ian" sort="Mcneish, Ian" uniqKey="Mcneish I" first="Ian" last="Mcneish">Ian Mcneish</name><affiliation><nlm:aff id="A186">Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Paul, James" sort="Paul, James" uniqKey="Paul J" first="James" last="Paul">James Paul</name><affiliation><nlm:aff id="A187">Cancer Research UK Clinical Trials Unit, Glasgow, The Beatson West of Scotland Cancer Centre, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Carty, Karen" sort="Carty, Karen" uniqKey="Carty K" first="Karen" last="Carty">Karen Carty</name><affiliation><nlm:aff id="A187">Cancer Research UK Clinical Trials Unit, Glasgow, The Beatson West of Scotland Cancer Centre, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Siddiqui, Nadeem" sort="Siddiqui, Nadeem" uniqKey="Siddiqui N" first="Nadeem" last="Siddiqui">Nadeem Siddiqui</name><affiliation><nlm:aff id="A188">Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Glasspool, Rosalind" sort="Glasspool, Rosalind" uniqKey="Glasspool R" first="Rosalind" last="Glasspool">Rosalind Glasspool</name><affiliation><nlm:aff id="A187">Cancer Research UK Clinical Trials Unit, Glasgow, The Beatson West of Scotland Cancer Centre, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name><affiliation><nlm:aff id="A189">Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Rothstein, Joseph H" sort="Rothstein, Joseph H" uniqKey="Rothstein J" first="Joseph H." last="Rothstein">Joseph H. Rothstein</name><affiliation><nlm:aff id="A189">Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Mcguire, Valerie" sort="Mcguire, Valerie" uniqKey="Mcguire V" first="Valerie" last="Mcguire">Valerie Mcguire</name><affiliation><nlm:aff id="A189">Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Sieh, Weiva" sort="Sieh, Weiva" uniqKey="Sieh W" first="Weiva" last="Sieh">Weiva Sieh</name><affiliation><nlm:aff id="A189">Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Ji, Bu Tian" sort="Ji, Bu Tian" uniqKey="Ji B" first="Bu-Tian" last="Ji">Bu-Tian Ji</name><affiliation><nlm:aff id="A182">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="A190">Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation><nlm:aff id="A190">Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Gao, Yu Tang" sort="Gao, Yu Tang" uniqKey="Gao Y" first="Yu-Tang" last="Gao">Yu-Tang Gao</name><affiliation><nlm:aff id="A191">Shanghai Cancer Institute, Shanghai, China</nlm:aff></affiliation></author><author><name sortKey="Rosen, Barry" sort="Rosen, Barry" uniqKey="Rosen B" first="Barry" last="Rosen">Barry Rosen</name><affiliation><nlm:aff id="A192">Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A193">Department of Gynecologic-Oncology, Princess Margaret Hospital, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Risch, Harvey A" sort="Risch, Harvey A" uniqKey="Risch H" first="Harvey A." last="Risch">Harvey A. Risch</name><affiliation><nlm:aff id="A194">Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA</nlm:aff></affiliation></author><author><name sortKey="Mclaughlin, John R" sort="Mclaughlin, John R" uniqKey="Mclaughlin J" first="John R." last="Mclaughlin">John R. Mclaughlin</name><affiliation><nlm:aff id="A195">Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Narod, Steven A" sort="Narod, Steven A" uniqKey="Narod S" first="Steven A." last="Narod">Steven A. Narod</name><affiliation><nlm:aff id="A196">Women's College Research Institute, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Monteiro, Alvaro N" sort="Monteiro, Alvaro N" uniqKey="Monteiro A" first="Alvaro N." last="Monteiro">Alvaro N. Monteiro</name><affiliation><nlm:aff id="A93">Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Chen, Ann" sort="Chen, Ann" uniqKey="Chen A" first="Ann" last="Chen">Ann Chen</name><affiliation><nlm:aff id="A197">Department of Biostatistics, Moffitt Cancer Center, Tampa, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Lin, Hui Yi" sort="Lin, Hui Yi" uniqKey="Lin H" first="Hui-Yi" last="Lin">Hui-Yi Lin</name><affiliation><nlm:aff id="A197">Department of Biostatistics, Moffitt Cancer Center, Tampa, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Permuth Wey, Jenny" sort="Permuth Wey, Jenny" uniqKey="Permuth Wey J" first="Jenny" last="Permuth-Wey">Jenny Permuth-Wey</name><affiliation><nlm:aff id="A93">Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Sellers, Thomas A" sort="Sellers, Thomas A" uniqKey="Sellers T" first="Thomas A." last="Sellers">Thomas A. Sellers</name><affiliation><nlm:aff id="A93">Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Tsai, Ya Yu" sort="Tsai, Ya Yu" uniqKey="Tsai Y" first="Ya-Yu" last="Tsai">Ya-Yu Tsai</name><affiliation><nlm:aff id="A93">Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Chen, Zhihua" sort="Chen, Zhihua" uniqKey="Chen Z" first="Zhihua" last="Chen">Zhihua Chen</name><affiliation><nlm:aff id="A197">Department of Biostatistics, Moffitt Cancer Center, Tampa, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name><affiliation><nlm:aff id="A198">Department of Epidemiology, University of California Irvine, Irvine, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="A198">Department of Epidemiology, University of California Irvine, Irvine, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Gentry Maharaj, Aleksandra" sort="Gentry Maharaj, Aleksandra" uniqKey="Gentry Maharaj A" first="Aleksandra" last="Gentry-Maharaj">Aleksandra Gentry-Maharaj</name><affiliation><nlm:aff id="A199">Women's Cancer, UCL EGA Institute for Women's Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Menon, Usha" sort="Menon, Usha" uniqKey="Menon U" first="Usha" last="Menon">Usha Menon</name><affiliation><nlm:aff id="A199">Women's Cancer, UCL EGA Institute for Women's Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Harrington, Patricia" sort="Harrington, Patricia" uniqKey="Harrington P" first="Patricia" last="Harrington">Patricia Harrington</name><affiliation><nlm:aff id="A3">Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Lee, Alice W" sort="Lee, Alice W" uniqKey="Lee A" first="Alice W." last="Lee">Alice W. Lee</name><affiliation><nlm:aff id="A2">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H." last="Wu">Anna H. Wu</name><affiliation><nlm:aff id="A2">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Pearce, Celeste L" sort="Pearce, Celeste L" uniqKey="Pearce C" first="Celeste L." last="Pearce">Celeste L. Pearce</name><affiliation><nlm:aff id="A2">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Coetzee, Gerhard A" sort="Coetzee, Gerhard A" uniqKey="Coetzee G" first="Gerhard A." last="Coetzee">Gerhard A. Coetzee</name><affiliation><nlm:aff id="A12">Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Department of Urology, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Pike, Malcolm C" sort="Pike, Malcolm C" uniqKey="Pike M" first="Malcolm C." last="Pike">Malcolm C. Pike</name><affiliation><nlm:aff id="A2">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A200">Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Dansonka Mieszkowska, Agnieszka" sort="Dansonka Mieszkowska, Agnieszka" uniqKey="Dansonka Mieszkowska A" first="Agnieszka" last="Dansonka-Mieszkowska">Agnieszka Dansonka-Mieszkowska</name><affiliation><nlm:aff id="A201">Department of Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Timorek, Agnieszka" sort="Timorek, Agnieszka" uniqKey="Timorek A" first="Agnieszka" last="Timorek">Agnieszka Timorek</name><affiliation><nlm:aff id="A202">Department of Obstetrics, Gynecology and Oncology, IInd Faculty of Medicine, Warsaw Medical University and Brodnowski Hospital, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Rzepecka, Iwona K" sort="Rzepecka, Iwona K" uniqKey="Rzepecka I" first="Iwona K." last="Rzepecka">Iwona K. Rzepecka</name><affiliation><nlm:aff id="A201">Department of Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Kupryjanczyk, Jolanta" sort="Kupryjanczyk, Jolanta" uniqKey="Kupryjanczyk J" first="Jolanta" last="Kupryjanczyk">Jolanta Kupryjanczyk</name><affiliation><nlm:aff id="A201">Department of Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Freedman, Matt" sort="Freedman, Matt" uniqKey="Freedman M" first="Matt" last="Freedman">Matt Freedman</name><affiliation><nlm:aff id="A8">Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Noushmehr, Houtan" sort="Noushmehr, Houtan" uniqKey="Noushmehr H" first="Houtan" last="Noushmehr">Houtan Noushmehr</name><affiliation><nlm:aff id="A9">Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Brazil</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Center For Cell Based Therapy, Monte Alegre, Ribeirão Preto, SP, Brazil</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Center for Integrative Systems Biology, Monte Alegre, Ribeirão Preto, SP, Brazil</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><nlm:aff id="A91">Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A88">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A89">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Gayther, Simon" sort="Gayther, Simon" uniqKey="Gayther S" first="Simon" last="Gayther">Simon Gayther</name><affiliation><nlm:aff id="A2">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul P" sort="Pharoah, Paul P" uniqKey="Pharoah P" first="Paul P." last="Pharoah">Paul P. Pharoah</name><affiliation><nlm:aff id="A3">Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A4">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25581431</idno><idno type="pmc">4445140</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445140</idno><idno type="RBID">PMC:4445140</idno><idno type="doi">10.1038/ng.3185</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002E39</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E39</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Identification of six new susceptibility loci for invasive epithelial ovarian cancer</title><author><name sortKey="Kuchenbaecker, Karoline B" sort="Kuchenbaecker, Karoline B" uniqKey="Kuchenbaecker K" first="Karoline B." last="Kuchenbaecker">Karoline B. Kuchenbaecker</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Ramus, Susan J" sort="Ramus, Susan J" uniqKey="Ramus S" first="Susan J." last="Ramus">Susan J. Ramus</name><affiliation><nlm:aff id="A2">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Tyrer, Jonathan" sort="Tyrer, Jonathan" uniqKey="Tyrer J" first="Jonathan" last="Tyrer">Jonathan Tyrer</name><affiliation><nlm:aff id="A3">Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Lee, Andrew" sort="Lee, Andrew" uniqKey="Lee A" first="Andrew" last="Lee">Andrew Lee</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Shen, Howard C" sort="Shen, Howard C" uniqKey="Shen H" first="Howard C." last="Shen">Howard C. Shen</name><affiliation><nlm:aff id="A2">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="A4">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia</nlm:aff></affiliation></author><author><name sortKey="Lawrenson, Kate" sort="Lawrenson, Kate" uniqKey="Lawrenson K" first="Kate" last="Lawrenson">Kate Lawrenson</name><affiliation><nlm:aff id="A2">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name><affiliation><nlm:aff id="A4">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia</nlm:aff></affiliation></author><author><name sortKey="Lee, Janet M" sort="Lee, Janet M" uniqKey="Lee J" first="Janet M." last="Lee">Janet M. Lee</name><affiliation><nlm:aff id="A2">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Spindler, Tassja J" sort="Spindler, Tassja J" uniqKey="Spindler T" first="Tassja J." last="Spindler">Tassja J. Spindler</name><affiliation><nlm:aff id="A2">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Lin, Yvonne G" sort="Lin, Yvonne G" uniqKey="Lin Y" first="Yvonne G." last="Lin">Yvonne G. Lin</name><affiliation><nlm:aff id="A5">Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Pejovic, Tanja" sort="Pejovic, Tanja" uniqKey="Pejovic T" first="Tanja" last="Pejovic">Tanja Pejovic</name><affiliation><nlm:aff id="A6">Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Knight Cancer Institute, Portland, OR, USA</nlm:aff></affiliation></author><author><name sortKey="Bean, Yukie" sort="Bean, Yukie" uniqKey="Bean Y" first="Yukie" last="Bean">Yukie Bean</name><affiliation><nlm:aff id="A6">Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Knight Cancer Institute, Portland, OR, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Qiyuan" sort="Li, Qiyuan" uniqKey="Li Q" first="Qiyuan" last="Li">Qiyuan Li</name><affiliation><nlm:aff id="A8">Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Coetzee, Simon" sort="Coetzee, Simon" uniqKey="Coetzee S" first="Simon" last="Coetzee">Simon Coetzee</name><affiliation><nlm:aff id="A9">Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Brazil</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Center For Cell Based Therapy, Monte Alegre, Ribeirão Preto, SP, Brazil</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Center for Integrative Systems Biology, Monte Alegre, Ribeirão Preto, SP, Brazil</nlm:aff></affiliation></author><author><name sortKey="Hazelett, Dennis" sort="Hazelett, Dennis" uniqKey="Hazelett D" first="Dennis" last="Hazelett">Dennis Hazelett</name><affiliation><nlm:aff id="A12">Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Department of Urology, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Miron, Alexander" sort="Miron, Alexander" uniqKey="Miron A" first="Alexander" last="Miron">Alexander Miron</name><affiliation><nlm:aff id="A14">Department of Genomics and Genome Sciences, Case Western Reserve University Medical School, Cleveland, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa" sort="Southey, Melissa" uniqKey="Southey M" first="Melissa" last="Southey">Melissa Southey</name><affiliation><nlm:aff id="A15">Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, VIC, Australia</nlm:aff></affiliation></author><author><name sortKey="Terry, Mary Beth" sort="Terry, Mary Beth" uniqKey="Terry M" first="Mary Beth" last="Terry">Mary Beth Terry</name><affiliation><nlm:aff id="A16">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E." last="Goldgar">David E. Goldgar</name><affiliation><nlm:aff id="A17">Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA</nlm:aff></affiliation></author><author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S." last="Buys">Saundra S. Buys</name><affiliation><nlm:aff id="A18">Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, USA</nlm:aff></affiliation></author><author><name sortKey="Janavicius, Ramunas" sort="Janavicius, Ramunas" uniqKey="Janavicius R" first="Ramunas" last="Janavicius">Ramunas Janavicius</name><affiliation><nlm:aff id="A19">Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius, Lithuania</nlm:aff></affiliation><affiliation><nlm:aff id="A20">State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania</nlm:aff></affiliation></author><author><name sortKey="Dorfling, Cecilia M" sort="Dorfling, Cecilia M" uniqKey="Dorfling C" first="Cecilia M." last="Dorfling">Cecilia M. Dorfling</name><affiliation><nlm:aff id="A21">Department of Genetics, University of Pretoria, Pretoria, South Africa</nlm:aff></affiliation></author><author><name sortKey="Van Rensburg, Elizabeth J" sort="Van Rensburg, Elizabeth J" uniqKey="Van Rensburg E" first="Elizabeth J." last="Van Rensburg">Elizabeth J. Van Rensburg</name><affiliation><nlm:aff id="A21">Department of Genetics, University of Pretoria, Pretoria, South Africa</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="A22">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Ding, Yuan Chun" sort="Ding, Yuan Chun" uniqKey="Ding Y" first="Yuan Chun" last="Ding">Yuan Chun Ding</name><affiliation><nlm:aff id="A22">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V. O." last="Hansen">Thomas V. O. Hansen</name><affiliation><nlm:aff id="A23">Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="J Nson, Lars" sort="J Nson, Lars" uniqKey="J Nson L" first="Lars" last="J Nson">Lars J Nson</name><affiliation><nlm:aff id="A23">Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Gerdes, Anne Marie" sort="Gerdes, Anne Marie" uniqKey="Gerdes A" first="Anne-Marie" last="Gerdes">Anne-Marie Gerdes</name><affiliation><nlm:aff id="A24">Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Ejlertsen, Bent" sort="Ejlertsen, Bent" uniqKey="Ejlertsen B" first="Bent" last="Ejlertsen">Bent Ejlertsen</name><affiliation><nlm:aff id="A25">Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Barrowdale, Daniel" sort="Barrowdale, Daniel" uniqKey="Barrowdale D" first="Daniel" last="Barrowdale">Daniel Barrowdale</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="A26">Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Genotyping Unit (CeGen), Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name><affiliation><nlm:aff id="A26">Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Garcia, Maria Jose" sort="Garcia, Maria Jose" uniqKey="Garcia M" first="Maria Jose" last="Garcia">Maria Jose Garcia</name><affiliation><nlm:aff id="A26">Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Komenaka, Ian" sort="Komenaka, Ian" uniqKey="Komenaka I" first="Ian" last="Komenaka">Ian Komenaka</name><affiliation><nlm:aff id="A29">Maricopa Medical Center, care of City of Hope Clinical Cancer Genetics Community Research Network, Duarte, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Weitzel, Jeffrey N" sort="Weitzel, Jeffrey N" uniqKey="Weitzel J" first="Jeffrey N." last="Weitzel">Jeffrey N. Weitzel</name><affiliation><nlm:aff id="A30">Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network, Duarte, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Ganschow, Pamela" sort="Ganschow, Pamela" uniqKey="Ganschow P" first="Pamela" last="Ganschow">Pamela Ganschow</name><affiliation><nlm:aff id="A31">Cook County Health and Hospital System, care of City of Hope Clinical Cancer Genetics Community Research Network, Duarte, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A32">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Bernard, Loris" sort="Bernard, Loris" uniqKey="Bernard L" first="Loris" last="Bernard">Loris Bernard</name><affiliation><nlm:aff id="A33">Department of Experimental Oncology, Istituto Europeo di Oncologia, Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Cogentech Cancer Genetic Test Laboratory, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Viel, Alessandra" sort="Viel, Alessandra" uniqKey="Viel A" first="Alessandra" last="Viel">Alessandra Viel</name><affiliation><nlm:aff id="A35">Division of Experimental Oncology, CRO Aviano National Cancer Institute, Aviano (PN), Italy</nlm:aff></affiliation></author><author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name><affiliation><nlm:aff id="A36">Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Peissel, Bernard" sort="Peissel, Bernard" uniqKey="Peissel B" first="Bernard" last="Peissel">Bernard Peissel</name><affiliation><nlm:aff id="A37">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="A37">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="A38">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Papi, Laura" sort="Papi, Laura" uniqKey="Papi L" first="Laura" last="Papi">Laura Papi</name><affiliation><nlm:aff id="A39">Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Ottini, Laura" sort="Ottini, Laura" uniqKey="Ottini L" first="Laura" last="Ottini">Laura Ottini</name><affiliation><nlm:aff id="A40">Department of Molecular Medicine, University La Sapienza, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Fostira, Florentia" sort="Fostira, Florentia" uniqKey="Fostira F" first="Florentia" last="Fostira">Florentia Fostira</name><affiliation><nlm:aff id="A41">Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research "Demokritos", Aghia Paraskevi Attikis, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Konstantopoulou, Irene" sort="Konstantopoulou, Irene" uniqKey="Konstantopoulou I" first="Irene" last="Konstantopoulou">Irene Konstantopoulou</name><affiliation><nlm:aff id="A41">Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research "Demokritos", Aghia Paraskevi Attikis, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Garber, Judy" sort="Garber, Judy" uniqKey="Garber J" first="Judy" last="Garber">Judy Garber</name><affiliation><nlm:aff id="A42">Cancer Risk and Prevention Clinic, Dana Farber Cancer Institute, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Perkins, Jo" sort="Perkins, Jo" uniqKey="Perkins J" first="Jo" last="Perkins">Jo Perkins</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Platte, Radka" sort="Platte, Radka" uniqKey="Platte R" first="Radka" last="Platte">Radka Platte</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Ellis, Steve" sort="Ellis, Steve" uniqKey="Ellis S" first="Steve" last="Ellis">Steve Ellis</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name><affiliation><nlm:aff id="A43">Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita Katharina" sort="Schmutzler, Rita Katharina" uniqKey="Schmutzler R" first="Rita Katharina" last="Schmutzler">Rita Katharina Schmutzler</name><affiliation><nlm:aff id="A44">Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A45">Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A46">Center for Molecular Medicine Cologne (CMMC), University of Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A47">Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name><affiliation><nlm:aff id="A48">Institute for Medical Informatics, Statistics and Epidemiology University of Leipzig, Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name><affiliation><nlm:aff id="A49">University Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name><affiliation><nlm:aff id="A50">INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A51">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon – Centre Léon Bérard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Damiola, Francesca" sort="Damiola, Francesca" uniqKey="Damiola F" first="Francesca" last="Damiola">Francesca Damiola</name><affiliation><nlm:aff id="A50">INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name><affiliation><nlm:aff id="A50">INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation><nlm:aff id="A52">Institut Curie, Department of Tumour Biology, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A53">Institut Curie, INSERM U830, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Université Paris Descartes, Sorbonne Paris Cité, France</nlm:aff></affiliation></author><author><name sortKey="Claes, Kathleen" sort="Claes, Kathleen" uniqKey="Claes K" first="Kathleen" last="Claes">Kathleen Claes</name><affiliation><nlm:aff id="A55">Center for Medical Genetics, Ghent University, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="De Leeneer, Kim" sort="De Leeneer, Kim" uniqKey="De Leeneer K" first="Kim" last="De Leeneer">Kim De Leeneer</name><affiliation><nlm:aff id="A55">Center for Medical Genetics, Ghent University, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="Kirk, Judy" sort="Kirk, Judy" uniqKey="Kirk J" first="Judy" last="Kirk">Judy Kirk</name><affiliation><nlm:aff id="A56">Australia New Zealand Gynecologic Oncology Group (ANZGOG) and Familial Cancer Service, Westmead Hosptial, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Rodriguez, Gustavo C" sort="Rodriguez, Gustavo C" uniqKey="Rodriguez G" first="Gustavo C." last="Rodriguez">Gustavo C. Rodriguez</name><affiliation><nlm:aff id="A57">Division of Gynecologic Oncology, NorthShore University HealthSystem, Evanston, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Piedmonte, Marion" sort="Piedmonte, Marion" uniqKey="Piedmonte M" first="Marion" last="Piedmonte">Marion Piedmonte</name><affiliation><nlm:aff id="A58">Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, NY, USA</nlm:aff></affiliation></author><author><name sortKey="O Malley, David M" sort="O Malley, David M" uniqKey="O Malley D" first="David M." last="O'Malley">David M. O'Malley</name><affiliation><nlm:aff id="A59">James Cancer Center, Ohio State University, Columbus, OH, USA</nlm:aff></affiliation></author><author><name sortKey="De La Hoya, Miguel" sort="De La Hoya, Miguel" uniqKey="De La Hoya M" first="Miguel" last="De La Hoya">Miguel De La Hoya</name><affiliation><nlm:aff id="A60">Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name><affiliation><nlm:aff id="A60">Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="A61">Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A62">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Collee, J Margriet" sort="Collee, J Margriet" uniqKey="Collee J" first="J. Margriet" last="Collée">J. Margriet Collée</name><affiliation><nlm:aff id="A63">Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Rookus, Matti A" sort="Rookus, Matti A" uniqKey="Rookus M" first="Matti A." last="Rookus">Matti A. Rookus</name><affiliation><nlm:aff id="A64">Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Oosterwijk, Jan C" sort="Oosterwijk, Jan C" uniqKey="Oosterwijk J" first="Jan C." last="Oosterwijk">Jan C. Oosterwijk</name><affiliation><nlm:aff id="A65">Department of Genetics, University Medical Center, Groningen University, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Tihomirova, Laima" sort="Tihomirova, Laima" uniqKey="Tihomirova L" first="Laima" last="Tihomirova">Laima Tihomirova</name><affiliation><nlm:aff id="A66">Latvian Biomedical Research and Study Centre, Riga, Latvia</nlm:aff></affiliation></author><author><name sortKey="Tung, Nadine" sort="Tung, Nadine" uniqKey="Tung N" first="Nadine" last="Tung">Nadine Tung</name><affiliation><nlm:aff id="A67">Department of Medical Oncology, Beth Israel Deaconess Medical Center</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="A68">Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name><affiliation><nlm:aff id="A69">Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, USA</nlm:aff></affiliation></author><author><name sortKey="Tischkowitz, Marc" sort="Tischkowitz, Marc" uniqKey="Tischkowitz M" first="Marc" last="Tischkowitz">Marc Tischkowitz</name><affiliation><nlm:aff id="A70">Program in Cancer Genetics, McGill University, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Imyanitov, Evgeny N" sort="Imyanitov, Evgeny N" uniqKey="Imyanitov E" first="Evgeny N." last="Imyanitov">Evgeny N. Imyanitov</name><affiliation><nlm:aff id="A71">N.N. Petrov Institute of Oncology, St.Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A." last="Caligo">Maria A. Caligo</name><affiliation><nlm:aff id="A72">Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, Pisa, Italy</nlm:aff></affiliation></author><author><name sortKey="Campbell, Ian" sort="Campbell, Ian" uniqKey="Campbell I" first="Ian" last="Campbell">Ian Campbell</name><affiliation><nlm:aff id="A73">VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B. L." last="Hogervorst">Frans B. L. Hogervorst</name><affiliation><nlm:aff id="A74">Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name><affiliation><nlm:aff id="A75">Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary</nlm:aff></affiliation></author><author><name sortKey="Diez, Orland" sort="Diez, Orland" uniqKey="Diez O" first="Orland" last="Diez">Orland Diez</name><affiliation><nlm:aff id="A76">Oncogenetics Group, University Hospital Vall d’Hebron, Vall d’Hebron Institute of Oncology (VHIO) and Universitat Autònoma de Barcelona; Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Blanco, Ignacio" sort="Blanco, Ignacio" uniqKey="Blanco I" first="Ignacio" last="Blanco">Ignacio Blanco</name><affiliation><nlm:aff id="A77">Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Brunet, Joan" sort="Brunet, Joan" uniqKey="Brunet J" first="Joan" last="Brunet">Joan Brunet</name><affiliation><nlm:aff id="A78">Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI-Catalan Institute of Oncology, Girona, Spain</nlm:aff></affiliation></author><author><name sortKey="Lazaro, Conxi" sort="Lazaro, Conxi" uniqKey="Lazaro C" first="Conxi" last="Lazaro">Conxi Lazaro</name><affiliation><nlm:aff id="A79">Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Pujana, Miquel Angel" sort="Pujana, Miquel Angel" uniqKey="Pujana M" first="Miquel Angel" last="Pujana">Miquel Angel Pujana</name><affiliation><nlm:aff id="A80">Breast Cancer and Systems Biology Unit, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="A81">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name><affiliation><nlm:aff id="A81">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="A81">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Sukiennicki, Grzegorz" sort="Sukiennicki, Grzegorz" uniqKey="Sukiennicki G" first="Grzegorz" last="Sukiennicki">Grzegorz Sukiennicki</name><affiliation><nlm:aff id="A81">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Barkardottir, Rosa B" sort="Barkardottir, Rosa B" uniqKey="Barkardottir R" first="Rosa B." last="Barkardottir">Rosa B. Barkardottir</name><affiliation><nlm:aff id="A82">Department of Pathology, Landspitali University Hospital and BMC, Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Plante, Marie" sort="Plante, Marie" uniqKey="Plante M" first="Marie" last="Plante">Marie Plante</name><affiliation><nlm:aff id="A83">Gynaecologic Oncology Service, Centre Hospitalier Universitaire de Québec (CHUQ), Québec, Canada</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="A84">Centre Hospitalier Universitaire de Québec Research Center, Laval University, Quebec City, Canada</nlm:aff></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation><nlm:aff id="A84">Centre Hospitalier Universitaire de Québec Research Center, Laval University, Quebec City, Canada</nlm:aff></affiliation></author><author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name><affiliation><nlm:aff id="A85">Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Tognazzo, Silvia" sort="Tognazzo, Silvia" uniqKey="Tognazzo S" first="Silvia" last="Tognazzo">Silvia Tognazzo</name><affiliation><nlm:aff id="A85">Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Teixeira, Manuel R" sort="Teixeira, Manuel R" uniqKey="Teixeira M" first="Manuel R." last="Teixeira">Manuel R. Teixeira</name><affiliation><nlm:aff id="A86">Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Department of Genetics, Portuguese Oncology Institute, Porto, Portugal</nlm:aff></affiliation></author><author><name sortKey="Pankratz, Vernon S" sort="Pankratz, Vernon S" uniqKey="Pankratz V" first="Vernon S." last="Pankratz">Vernon S. Pankratz</name><affiliation><nlm:aff id="A88">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff id="A89">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Lindor, Noralane" sort="Lindor, Noralane" uniqKey="Lindor N" first="Noralane" last="Lindor">Noralane Lindor</name><affiliation><nlm:aff id="A88">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I." last="Szabo">Csilla I. Szabo</name><affiliation><nlm:aff id="A90">National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Kauff, Noah" sort="Kauff, Noah" uniqKey="Kauff N" first="Noah" last="Kauff">Noah Kauff</name><affiliation><nlm:aff id="A91">Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name><affiliation><nlm:aff id="A91">Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Aghajanian, Carol A" sort="Aghajanian, Carol A" uniqKey="Aghajanian C" first="Carol A." last="Aghajanian">Carol A. Aghajanian</name><affiliation><nlm:aff id="A91">Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Pfeiler, Georg" sort="Pfeiler, Georg" uniqKey="Pfeiler G" first="Georg" last="Pfeiler">Georg Pfeiler</name><affiliation><nlm:aff id="A92">Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Berger, Andreas" sort="Berger, Andreas" uniqKey="Berger A" first="Andreas" last="Berger">Andreas Berger</name><affiliation><nlm:aff id="A92">Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Singer, Christian F" sort="Singer, Christian F" uniqKey="Singer C" first="Christian F." last="Singer">Christian F. Singer</name><affiliation><nlm:aff id="A92">Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Tea, Muy Kheng" sort="Tea, Muy Kheng" uniqKey="Tea M" first="Muy-Kheng" last="Tea">Muy-Kheng Tea</name><affiliation><nlm:aff id="A92">Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Phelan, Catherine M" sort="Phelan, Catherine M" uniqKey="Phelan C" first="Catherine M." last="Phelan">Catherine M. Phelan</name><affiliation><nlm:aff id="A93">Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><affiliation><nlm:aff id="A94">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L." last="Mai">Phuong L. Mai</name><affiliation><nlm:aff id="A94">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation><nlm:aff id="A95">Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel</nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="A96">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A97">Laboratory Medicine Program, University Health Network, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Tchatchou, Sandrine" sort="Tchatchou, Sandrine" uniqKey="Tchatchou S" first="Sandrine" last="Tchatchou">Sandrine Tchatchou</name><affiliation><nlm:aff id="A98">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A96">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A99">Department of Molecular Genetics, University of Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="A98">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda Ewart" sort="Toland, Amanda Ewart" uniqKey="Toland A" first="Amanda Ewart" last="Toland">Amanda Ewart Toland</name><affiliation><nlm:aff id="A100">Department of Molecular Virology, Immunology and Medical Genetics, Columbus, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Jensen, Uffe Birk" sort="Jensen, Uffe Birk" uniqKey="Jensen U" first="Uffe Birk" last="Jensen">Uffe Birk Jensen</name><affiliation><nlm:aff id="A101">Department of Clinical Genetics, Aarhus University Hospital, Aarhus N, Denmark</nlm:aff></affiliation></author><author><name sortKey="Kruse, Torben A" sort="Kruse, Torben A" uniqKey="Kruse T" first="Torben A." last="Kruse">Torben A. Kruse</name><affiliation><nlm:aff id="A102">Department of Clinical Genetics, Odense University Hospital, Odense C, Denmark</nlm:aff></affiliation></author><author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name><affiliation><nlm:aff id="A102">Department of Clinical Genetics, Odense University Hospital, Odense C, Denmark</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Anders" sort="Bojesen, Anders" uniqKey="Bojesen A" first="Anders" last="Bojesen">Anders Bojesen</name><affiliation><nlm:aff id="A103">Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark</nlm:aff></affiliation></author><author><name sortKey="Zidan, Jamal" sort="Zidan, Jamal" uniqKey="Zidan J" first="Jamal" last="Zidan">Jamal Zidan</name><affiliation><nlm:aff id="A104">Institute of Oncology, Rivka Ziv Medical Center, Zefat, Israel</nlm:aff></affiliation></author><author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><affiliation><nlm:aff id="A105">Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel Aviv, Israel</nlm:aff></affiliation></author><author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name><affiliation><nlm:aff id="A105">Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel Aviv, Israel</nlm:aff></affiliation></author><author><name sortKey="Soller, Maria" sort="Soller, Maria" uniqKey="Soller M" first="Maria" last="Soller">Maria Soller</name><affiliation><nlm:aff id="A106">Department of Clinical Genetics, Lund University Hospital, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Liljegren, Annelie" sort="Liljegren, Annelie" uniqKey="Liljegren A" first="Annelie" last="Liljegren">Annelie Liljegren</name><affiliation><nlm:aff id="A107">Department of Oncology, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Arver, Brita" sort="Arver, Brita" uniqKey="Arver B" first="Brita" last="Arver">Brita Arver</name><affiliation><nlm:aff id="A107">Department of Oncology, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Einbeigi, Zakaria" sort="Einbeigi, Zakaria" uniqKey="Einbeigi Z" first="Zakaria" last="Einbeigi">Zakaria Einbeigi</name><affiliation><nlm:aff id="A108">Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Stenmark Askmalm, Marie" sort="Stenmark Askmalm, Marie" uniqKey="Stenmark Askmalm M" first="Marie" last="Stenmark-Askmalm">Marie Stenmark-Askmalm</name><affiliation><nlm:aff id="A109">Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden</nlm:aff></affiliation></author><author><name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I." last="Olopade">Olufunmilayo I. Olopade</name><affiliation><nlm:aff id="A110">Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, USA</nlm:aff></affiliation></author><author><name sortKey="Nussbaum, Robert L" sort="Nussbaum, Robert L" uniqKey="Nussbaum R" first="Robert L." last="Nussbaum">Robert L. Nussbaum</name><affiliation><nlm:aff id="A111">Department of Medicine and Genetics, University of California, San Francisco, USA</nlm:aff></affiliation></author><author><name sortKey="Rebbeck, Timothy R" sort="Rebbeck, Timothy R" uniqKey="Rebbeck T" first="Timothy R." last="Rebbeck">Timothy R. Rebbeck</name><affiliation><nlm:aff id="A112">Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><affiliation><nlm:aff id="A112">Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M." last="Domchek">Susan M. Domchek</name><affiliation><nlm:aff id="A112">Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Lu, Karen H" sort="Lu, Karen H" uniqKey="Lu K" first="Karen H." last="Lu">Karen H. Lu</name><affiliation><nlm:aff id="A113">Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y." last="Karlan">Beth Y. Karlan</name><affiliation><nlm:aff id="A114">Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Walsh, Christine" sort="Walsh, Christine" uniqKey="Walsh C" first="Christine" last="Walsh">Christine Walsh</name><affiliation><nlm:aff id="A114">Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Lester, Jenny" sort="Lester, Jenny" uniqKey="Lester J" first="Jenny" last="Lester">Jenny Lester</name><affiliation><nlm:aff id="A114">Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Hein, Alexander" sort="Hein, Alexander" uniqKey="Hein A" first="Alexander" last="Hein">Alexander Hein</name><affiliation><nlm:aff id="A115">Department of Obstetrics and Gynecology, Erlangen University Hospital, University of Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="A116">Institute of Human Genetics, University of Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="A115">Department of Obstetrics and Gynecology, Erlangen University Hospital, University of Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="A115">Department of Obstetrics and Gynecology, Erlangen University Hospital, University of Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A117">University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="A118">Vesalius Research Center, VIB, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A119">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Nieuwenhuysen, Els Van" sort="Nieuwenhuysen, Els Van" uniqKey="Nieuwenhuysen E" first="Els Van" last="Nieuwenhuysen">Els Van Nieuwenhuysen</name><affiliation><nlm:aff id="A120">Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Vergote, Ignace" sort="Vergote, Ignace" uniqKey="Vergote I" first="Ignace" last="Vergote">Ignace Vergote</name><affiliation><nlm:aff id="A120">Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Sandrina" sort="Lambrechts, Sandrina" uniqKey="Lambrechts S" first="Sandrina" last="Lambrechts">Sandrina Lambrechts</name><affiliation><nlm:aff id="A120">Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Dicks, Ed" sort="Dicks, Ed" uniqKey="Dicks E" first="Ed" last="Dicks">Ed Dicks</name><affiliation><nlm:aff id="A3">Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Doherty, Jennifer A" sort="Doherty, Jennifer A" uniqKey="Doherty J" first="Jennifer A." last="Doherty">Jennifer A. Doherty</name><affiliation><nlm:aff id="A121">Department of Community and Family Medicine, Section of Biostatistics & Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA</nlm:aff></affiliation></author><author><name sortKey="Wicklund, Kristine G" sort="Wicklund, Kristine G" uniqKey="Wicklund K" first="Kristine G." last="Wicklund">Kristine G. Wicklund</name><affiliation><nlm:aff id="A122">Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Rossing, Mary Anne" sort="Rossing, Mary Anne" uniqKey="Rossing M" first="Mary Anne" last="Rossing">Mary Anne Rossing</name><affiliation><nlm:aff id="A122">Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A123">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="A124">German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A124">German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name><affiliation><nlm:aff id="A125">Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Eilber, Ursula" sort="Eilber, Ursula" uniqKey="Eilber U" first="Ursula" last="Eilber">Ursula Eilber</name><affiliation><nlm:aff id="A124">German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Moysich, Kirsten B" sort="Moysich, Kirsten B" uniqKey="Moysich K" first="Kirsten B." last="Moysich">Kirsten B. Moysich</name><affiliation><nlm:aff id="A126">Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Odunsi, Kunle" sort="Odunsi, Kunle" uniqKey="Odunsi K" first="Kunle" last="Odunsi">Kunle Odunsi</name><affiliation><nlm:aff id="A127">Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Sucheston Campbell, Lara" sort="Sucheston Campbell, Lara" uniqKey="Sucheston Campbell L" first="Lara" last="Sucheston-Campbell">Lara Sucheston-Campbell</name><affiliation><nlm:aff id="A126">Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Lele, Shashi" sort="Lele, Shashi" uniqKey="Lele S" first="Shashi" last="Lele">Shashi Lele</name><affiliation><nlm:aff id="A126">Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Wilkens, Lynne R" sort="Wilkens, Lynne R" uniqKey="Wilkens L" first="Lynne R." last="Wilkens">Lynne R. Wilkens</name><affiliation><nlm:aff id="A128">Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, USA</nlm:aff></affiliation></author><author><name sortKey="Goodman, Marc T" sort="Goodman, Marc T" uniqKey="Goodman M" first="Marc T." last="Goodman">Marc T. Goodman</name><affiliation><nlm:aff id="A129">Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A130">Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Thompson, Pamela J" sort="Thompson, Pamela J" uniqKey="Thompson P" first="Pamela J." last="Thompson">Pamela J. Thompson</name><affiliation><nlm:aff id="A129">Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A130">Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Shvetsov, Yurii B" sort="Shvetsov, Yurii B" uniqKey="Shvetsov Y" first="Yurii B." last="Shvetsov">Yurii B. Shvetsov</name><affiliation><nlm:aff id="A128">Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, USA</nlm:aff></affiliation></author><author><name sortKey="Runnebaum, Ingo B" sort="Runnebaum, Ingo B" uniqKey="Runnebaum I" first="Ingo B." last="Runnebaum">Ingo B. Runnebaum</name><affiliation><nlm:aff id="A131">Department of Gynecology, Jena University Hospital - Friedrich Schiller University, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Durst, Matthias" sort="Durst, Matthias" uniqKey="Durst M" first="Matthias" last="Dürst">Matthias Dürst</name><affiliation><nlm:aff id="A131">Department of Gynecology, Jena University Hospital - Friedrich Schiller University, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Hillemanns, Peter" sort="Hillemanns, Peter" uniqKey="Hillemanns P" first="Peter" last="Hillemanns">Peter Hillemanns</name><affiliation><nlm:aff id="A132">Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="A133">Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Antonenkova, Natalia" sort="Antonenkova, Natalia" uniqKey="Antonenkova N" first="Natalia" last="Antonenkova">Natalia Antonenkova</name><affiliation><nlm:aff id="A134">Byelorussian Institute for Oncology and Medical Radiology Aleksandrov N.N., Minsk, Belarus</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia" sort="Bogdanova, Natalia" uniqKey="Bogdanova N" first="Natalia" last="Bogdanova">Natalia Bogdanova</name><affiliation><nlm:aff id="A133">Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Leminen, Arto" sort="Leminen, Arto" uniqKey="Leminen A" first="Arto" last="Leminen">Arto Leminen</name><affiliation><nlm:aff id="A62">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Pelttari, Liisa M" sort="Pelttari, Liisa M" uniqKey="Pelttari L" first="Liisa M." last="Pelttari">Liisa M. Pelttari</name><affiliation><nlm:aff id="A62">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Butzow, Ralf" sort="Butzow, Ralf" uniqKey="Butzow R" first="Ralf" last="Butzow">Ralf Butzow</name><affiliation><nlm:aff id="A62">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A135">Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Modugno, Francesmary" sort="Modugno, Francesmary" uniqKey="Modugno F" first="Francesmary" last="Modugno">Francesmary Modugno</name><affiliation><nlm:aff id="A136">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A137">Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A138">Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A139">Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Kelley, Joseph L" sort="Kelley, Joseph L" uniqKey="Kelley J" first="Joseph L." last="Kelley">Joseph L. Kelley</name><affiliation><nlm:aff id="A137">Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Edwards, Robert P" sort="Edwards, Robert P" uniqKey="Edwards R" first="Robert P." last="Edwards">Robert P. Edwards</name><affiliation><nlm:aff id="A137">Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A138">Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Ness, Roberta B" sort="Ness, Roberta B" uniqKey="Ness R" first="Roberta B." last="Ness">Roberta B. Ness</name><affiliation><nlm:aff id="A140">The University of Texas School of Public Health, Houston, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Du Bois, Andreas" sort="Du Bois, Andreas" uniqKey="Du Bois A" first="Andreas" last="Du Bois">Andreas Du Bois</name><affiliation><nlm:aff id="A141">Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A142">Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Heitz, Florian" sort="Heitz, Florian" uniqKey="Heitz F" first="Florian" last="Heitz">Florian Heitz</name><affiliation><nlm:aff id="A141">Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A142">Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Schwaab, Ira" sort="Schwaab, Ira" uniqKey="Schwaab I" first="Ira" last="Schwaab">Ira Schwaab</name><affiliation><nlm:aff id="A143">Institut für Humangenetik Wiesbaden, Wiesbaden, Germany</nlm:aff></affiliation></author><author><name sortKey="Harter, Philipp" sort="Harter, Philipp" uniqKey="Harter P" first="Philipp" last="Harter">Philipp Harter</name><affiliation><nlm:aff id="A141">Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A142">Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name><affiliation><nlm:aff id="A144">Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Fukuoka, Japan</nlm:aff></affiliation></author><author><name sortKey="Hosono, Satoyo" sort="Hosono, Satoyo" uniqKey="Hosono S" first="Satoyo" last="Hosono">Satoyo Hosono</name><affiliation><nlm:aff id="A145">Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan</nlm:aff></affiliation></author><author><name sortKey="Orsulic, Sandra" sort="Orsulic, Sandra" uniqKey="Orsulic S" first="Sandra" last="Orsulic">Sandra Orsulic</name><affiliation><nlm:aff id="A114">Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Jensen, Allan" sort="Jensen, Allan" uniqKey="Jensen A" first="Allan" last="Jensen">Allan Jensen</name><affiliation><nlm:aff id="A146">Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Kjaer, Susanne Kruger" sort="Kjaer, Susanne Kruger" uniqKey="Kjaer S" first="Susanne Kruger" last="Kjaer">Susanne Kruger Kjaer</name><affiliation><nlm:aff id="A146">Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A147">Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Hogdall, Estrid" sort="Hogdall, Estrid" uniqKey="Hogdall E" first="Estrid" last="Hogdall">Estrid Hogdall</name><affiliation><nlm:aff id="A146">Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A148">Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Hasmad, Hanis Nazihah" sort="Hasmad, Hanis Nazihah" uniqKey="Hasmad H" first="Hanis Nazihah" last="Hasmad">Hanis Nazihah Hasmad</name><affiliation><nlm:aff id="A149">Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Noor Azmi, Mat Adenan" sort="Noor Azmi, Mat Adenan" uniqKey="Noor Azmi M" first="Mat Adenan" last="Noor Azmi">Mat Adenan Noor Azmi</name><affiliation><nlm:aff id="A150">Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo-Hwang" last="Teo">Soo-Hwang Teo</name><affiliation><nlm:aff id="A149">Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia</nlm:aff></affiliation><affiliation><nlm:aff id="A151">University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Woo, Yin Ling" sort="Woo, Yin Ling" uniqKey="Woo Y" first="Yin-Ling" last="Woo">Yin-Ling Woo</name><affiliation><nlm:aff id="A150">Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia</nlm:aff></affiliation><affiliation><nlm:aff id="A151">University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Fridley, Brooke L" sort="Fridley, Brooke L" uniqKey="Fridley B" first="Brooke L." last="Fridley">Brooke L. Fridley</name><affiliation><nlm:aff id="A152">Biostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, KS, USA</nlm:aff></affiliation></author><author><name sortKey="Goode, Ellen L" sort="Goode, Ellen L" uniqKey="Goode E" first="Ellen L." last="Goode">Ellen L. Goode</name><affiliation><nlm:aff id="A88">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Cunningham, Julie M" sort="Cunningham, Julie M" uniqKey="Cunningham J" first="Julie M." last="Cunningham">Julie M. Cunningham</name><affiliation><nlm:aff id="A89">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Vierkant, Robert A" sort="Vierkant, Robert A" uniqKey="Vierkant R" first="Robert A." last="Vierkant">Robert A. Vierkant</name><affiliation><nlm:aff id="A153">Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Bruinsma, Fiona" sort="Bruinsma, Fiona" uniqKey="Bruinsma F" first="Fiona" last="Bruinsma">Fiona Bruinsma</name><affiliation><nlm:aff id="A154">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="A154">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia</nlm:aff></affiliation></author><author><name sortKey="Liang, Dong" sort="Liang, Dong" uniqKey="Liang D" first="Dong" last="Liang">Dong Liang</name><affiliation><nlm:aff id="A155">College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Hildebrandt, Michelle A T" sort="Hildebrandt, Michelle A T" uniqKey="Hildebrandt M" first="Michelle A. T." last="Hildebrandt">Michelle A. T. Hildebrandt</name><affiliation><nlm:aff id="A156">Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Wu, Xifeng" sort="Wu, Xifeng" uniqKey="Wu X" first="Xifeng" last="Wu">Xifeng Wu</name><affiliation><nlm:aff id="A156">Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Levine, Douglas A" sort="Levine, Douglas A" uniqKey="Levine D" first="Douglas A." last="Levine">Douglas A. Levine</name><affiliation><nlm:aff id="A157">Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Bisogna, Maria" sort="Bisogna, Maria" uniqKey="Bisogna M" first="Maria" last="Bisogna">Maria Bisogna</name><affiliation><nlm:aff id="A157">Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Berchuck, Andrew" sort="Berchuck, Andrew" uniqKey="Berchuck A" first="Andrew" last="Berchuck">Andrew Berchuck</name><affiliation><nlm:aff id="A158">Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Iversen, Edwin S" sort="Iversen, Edwin S" uniqKey="Iversen E" first="Edwin S." last="Iversen">Edwin S. Iversen</name><affiliation><nlm:aff id="A159">Department of Statistical Science, Duke University, Durham, North Carolina, USA</nlm:aff></affiliation></author><author><name sortKey="Schildkraut, Joellen M" sort="Schildkraut, Joellen M" uniqKey="Schildkraut J" first="Joellen M." last="Schildkraut">Joellen M. Schildkraut</name><affiliation><nlm:aff id="A160">Cancer Control and Population Sciences, Duke Cancer Institute, Durham, North Carolina, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A161">Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Concannon, Patrick" sort="Concannon, Patrick" uniqKey="Concannon P" first="Patrick" last="Concannon">Patrick Concannon</name><affiliation><nlm:aff id="A162">Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Fl, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A163">Genetics Institute, University of Florida, Gainesville, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Weber, Rachel Palmieri" sort="Weber, Rachel Palmieri" uniqKey="Weber R" first="Rachel Palmieri" last="Weber">Rachel Palmieri Weber</name><affiliation><nlm:aff id="A161">Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Cramer, Daniel W" sort="Cramer, Daniel W" uniqKey="Cramer D" first="Daniel W." last="Cramer">Daniel W. Cramer</name><affiliation><nlm:aff id="A164">Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A165">Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Terry, Kathryn L" sort="Terry, Kathryn L" uniqKey="Terry K" first="Kathryn L." last="Terry">Kathryn L. Terry</name><affiliation><nlm:aff id="A164">Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A165">Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Poole, Elizabeth M" sort="Poole, Elizabeth M" uniqKey="Poole E" first="Elizabeth M." last="Poole">Elizabeth M. Poole</name><affiliation><nlm:aff id="A166">Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A167">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Tworoger, Shelley S" sort="Tworoger, Shelley S" uniqKey="Tworoger S" first="Shelley S." last="Tworoger">Shelley S. Tworoger</name><affiliation><nlm:aff id="A166">Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A167">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Bandera, Elisa V" sort="Bandera, Elisa V" uniqKey="Bandera E" first="Elisa V." last="Bandera">Elisa V. Bandera</name><affiliation><nlm:aff id="A168">Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA</nlm:aff></affiliation></author><author><name sortKey="Orlow, Irene" sort="Orlow, Irene" uniqKey="Orlow I" first="Irene" last="Orlow">Irene Orlow</name><affiliation><nlm:aff id="A169">Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, Epidemiology Service, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Olson, Sara H" sort="Olson, Sara H" uniqKey="Olson S" first="Sara H." last="Olson">Sara H. Olson</name><affiliation><nlm:aff id="A169">Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, Epidemiology Service, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Krakstad, Camilla" sort="Krakstad, Camilla" uniqKey="Krakstad C" first="Camilla" last="Krakstad">Camilla Krakstad</name><affiliation><nlm:aff id="A170">Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A171">Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway</nlm:aff></affiliation></author><author><name sortKey="Salvesen, Helga B" sort="Salvesen, Helga B" uniqKey="Salvesen H" first="Helga B." last="Salvesen">Helga B. Salvesen</name><affiliation><nlm:aff id="A170">Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A171">Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway</nlm:aff></affiliation></author><author><name sortKey="Tangen, Ingvild L" sort="Tangen, Ingvild L" uniqKey="Tangen I" first="Ingvild L." last="Tangen">Ingvild L. Tangen</name><affiliation><nlm:aff id="A170">Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A171">Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway</nlm:aff></affiliation></author><author><name sortKey="Bjorge, Line" sort="Bjorge, Line" uniqKey="Bjorge L" first="Line" last="Bjorge">Line Bjorge</name><affiliation><nlm:aff id="A170">Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A171">Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway</nlm:aff></affiliation></author><author><name sortKey="Van Altena, Anne M" sort="Van Altena, Anne M" uniqKey="Van Altena A" first="Anne M." last="Van Altena">Anne M. Van Altena</name><affiliation><nlm:aff id="A172">Department of Gynaecology, Radboud University Medical Centre, Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Aben, Katja K H" sort="Aben, Katja K H" uniqKey="Aben K" first="Katja K. H." last="Aben">Katja K. H. Aben</name><affiliation><nlm:aff id="A173">Comprehensive Cancer Center The Netherlands, Utrecht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A174">Department for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kiemeney, Lambertus A" sort="Kiemeney, Lambertus A" uniqKey="Kiemeney L" first="Lambertus A." last="Kiemeney">Lambertus A. Kiemeney</name><affiliation><nlm:aff id="A174">Department for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A175">Department of Urology, Radboud University Medical Centre, Nijmegen, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Massuger, Leon F A G" sort="Massuger, Leon F A G" uniqKey="Massuger L" first="Leon F. A. G." last="Massuger">Leon F. A. G. Massuger</name><affiliation><nlm:aff id="A172">Department of Gynaecology, Radboud University Medical Centre, Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kellar, Melissa" sort="Kellar, Melissa" uniqKey="Kellar M" first="Melissa" last="Kellar">Melissa Kellar</name><affiliation><nlm:aff id="A6">Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Knight Cancer Institute, Portland, OR, USA</nlm:aff></affiliation></author><author><name sortKey="Brooks Wilson, Angela" sort="Brooks Wilson, Angela" uniqKey="Brooks Wilson A" first="Angela" last="Brooks-Wilson">Angela Brooks-Wilson</name><affiliation><nlm:aff id="A176">Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A177">Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC Canada</nlm:aff></affiliation></author><author><name sortKey="Kelemen, Linda E" sort="Kelemen, Linda E" uniqKey="Kelemen L" first="Linda E." last="Kelemen">Linda E. Kelemen</name><affiliation><nlm:aff id="A178">Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, USA</nlm:aff></affiliation></author><author><name sortKey="Cook, Linda S" sort="Cook, Linda S" uniqKey="Cook L" first="Linda S." last="Cook">Linda S. Cook</name><affiliation><nlm:aff id="A179">Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA</nlm:aff></affiliation></author><author><name sortKey="Le, Nhu D" sort="Le, Nhu D" uniqKey="Le N" first="Nhu D." last="Le">Nhu D. Le</name><affiliation><nlm:aff id="A180">Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada</nlm:aff></affiliation></author><author><name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name><affiliation><nlm:aff id="A181">International Hereditary Cancer Center, Department of Genetics and Pathology, Clinic of Opthalmology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Yang, Hannah" sort="Yang, Hannah" uniqKey="Yang H" first="Hannah" last="Yang">Hannah Yang</name><affiliation><nlm:aff id="A182">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation><nlm:aff id="A183">Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Brinton, Louise A" sort="Brinton, Louise A" uniqKey="Brinton L" first="Louise A." last="Brinton">Louise A. Brinton</name><affiliation><nlm:aff id="A182">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Wentzensen, Nicolas" sort="Wentzensen, Nicolas" uniqKey="Wentzensen N" first="Nicolas" last="Wentzensen">Nicolas Wentzensen</name><affiliation><nlm:aff id="A182">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Hogdall, Claus" sort="Hogdall, Claus" uniqKey="Hogdall C" first="Claus" last="Hogdall">Claus Hogdall</name><affiliation><nlm:aff id="A147">Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Lundvall, Lene" sort="Lundvall, Lene" uniqKey="Lundvall L" first="Lene" last="Lundvall">Lene Lundvall</name><affiliation><nlm:aff id="A147">Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nedergaard, Lotte" sort="Nedergaard, Lotte" uniqKey="Nedergaard L" first="Lotte" last="Nedergaard">Lotte Nedergaard</name><affiliation><nlm:aff id="A184">Department of Pathology, Rigshospitalet, University of Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Baker, Helen" sort="Baker, Helen" uniqKey="Baker H" first="Helen" last="Baker">Helen Baker</name><affiliation><nlm:aff id="A3">Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Song, Honglin" sort="Song, Honglin" uniqKey="Song H" first="Honglin" last="Song">Honglin Song</name><affiliation><nlm:aff id="A3">Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Eccles, Diana" sort="Eccles, Diana" uniqKey="Eccles D" first="Diana" last="Eccles">Diana Eccles</name><affiliation><nlm:aff id="A185">Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Mcneish, Ian" sort="Mcneish, Ian" uniqKey="Mcneish I" first="Ian" last="Mcneish">Ian Mcneish</name><affiliation><nlm:aff id="A186">Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Paul, James" sort="Paul, James" uniqKey="Paul J" first="James" last="Paul">James Paul</name><affiliation><nlm:aff id="A187">Cancer Research UK Clinical Trials Unit, Glasgow, The Beatson West of Scotland Cancer Centre, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Carty, Karen" sort="Carty, Karen" uniqKey="Carty K" first="Karen" last="Carty">Karen Carty</name><affiliation><nlm:aff id="A187">Cancer Research UK Clinical Trials Unit, Glasgow, The Beatson West of Scotland Cancer Centre, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Siddiqui, Nadeem" sort="Siddiqui, Nadeem" uniqKey="Siddiqui N" first="Nadeem" last="Siddiqui">Nadeem Siddiqui</name><affiliation><nlm:aff id="A188">Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Glasspool, Rosalind" sort="Glasspool, Rosalind" uniqKey="Glasspool R" first="Rosalind" last="Glasspool">Rosalind Glasspool</name><affiliation><nlm:aff id="A187">Cancer Research UK Clinical Trials Unit, Glasgow, The Beatson West of Scotland Cancer Centre, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name><affiliation><nlm:aff id="A189">Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Rothstein, Joseph H" sort="Rothstein, Joseph H" uniqKey="Rothstein J" first="Joseph H." last="Rothstein">Joseph H. Rothstein</name><affiliation><nlm:aff id="A189">Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Mcguire, Valerie" sort="Mcguire, Valerie" uniqKey="Mcguire V" first="Valerie" last="Mcguire">Valerie Mcguire</name><affiliation><nlm:aff id="A189">Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Sieh, Weiva" sort="Sieh, Weiva" uniqKey="Sieh W" first="Weiva" last="Sieh">Weiva Sieh</name><affiliation><nlm:aff id="A189">Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Ji, Bu Tian" sort="Ji, Bu Tian" uniqKey="Ji B" first="Bu-Tian" last="Ji">Bu-Tian Ji</name><affiliation><nlm:aff id="A182">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="A190">Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation><nlm:aff id="A190">Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Gao, Yu Tang" sort="Gao, Yu Tang" uniqKey="Gao Y" first="Yu-Tang" last="Gao">Yu-Tang Gao</name><affiliation><nlm:aff id="A191">Shanghai Cancer Institute, Shanghai, China</nlm:aff></affiliation></author><author><name sortKey="Rosen, Barry" sort="Rosen, Barry" uniqKey="Rosen B" first="Barry" last="Rosen">Barry Rosen</name><affiliation><nlm:aff id="A192">Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A193">Department of Gynecologic-Oncology, Princess Margaret Hospital, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Risch, Harvey A" sort="Risch, Harvey A" uniqKey="Risch H" first="Harvey A." last="Risch">Harvey A. Risch</name><affiliation><nlm:aff id="A194">Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA</nlm:aff></affiliation></author><author><name sortKey="Mclaughlin, John R" sort="Mclaughlin, John R" uniqKey="Mclaughlin J" first="John R." last="Mclaughlin">John R. Mclaughlin</name><affiliation><nlm:aff id="A195">Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Narod, Steven A" sort="Narod, Steven A" uniqKey="Narod S" first="Steven A." last="Narod">Steven A. Narod</name><affiliation><nlm:aff id="A196">Women's College Research Institute, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Monteiro, Alvaro N" sort="Monteiro, Alvaro N" uniqKey="Monteiro A" first="Alvaro N." last="Monteiro">Alvaro N. Monteiro</name><affiliation><nlm:aff id="A93">Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Chen, Ann" sort="Chen, Ann" uniqKey="Chen A" first="Ann" last="Chen">Ann Chen</name><affiliation><nlm:aff id="A197">Department of Biostatistics, Moffitt Cancer Center, Tampa, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Lin, Hui Yi" sort="Lin, Hui Yi" uniqKey="Lin H" first="Hui-Yi" last="Lin">Hui-Yi Lin</name><affiliation><nlm:aff id="A197">Department of Biostatistics, Moffitt Cancer Center, Tampa, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Permuth Wey, Jenny" sort="Permuth Wey, Jenny" uniqKey="Permuth Wey J" first="Jenny" last="Permuth-Wey">Jenny Permuth-Wey</name><affiliation><nlm:aff id="A93">Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Sellers, Thomas A" sort="Sellers, Thomas A" uniqKey="Sellers T" first="Thomas A." last="Sellers">Thomas A. Sellers</name><affiliation><nlm:aff id="A93">Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Tsai, Ya Yu" sort="Tsai, Ya Yu" uniqKey="Tsai Y" first="Ya-Yu" last="Tsai">Ya-Yu Tsai</name><affiliation><nlm:aff id="A93">Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Chen, Zhihua" sort="Chen, Zhihua" uniqKey="Chen Z" first="Zhihua" last="Chen">Zhihua Chen</name><affiliation><nlm:aff id="A197">Department of Biostatistics, Moffitt Cancer Center, Tampa, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name><affiliation><nlm:aff id="A198">Department of Epidemiology, University of California Irvine, Irvine, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="A198">Department of Epidemiology, University of California Irvine, Irvine, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Gentry Maharaj, Aleksandra" sort="Gentry Maharaj, Aleksandra" uniqKey="Gentry Maharaj A" first="Aleksandra" last="Gentry-Maharaj">Aleksandra Gentry-Maharaj</name><affiliation><nlm:aff id="A199">Women's Cancer, UCL EGA Institute for Women's Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Menon, Usha" sort="Menon, Usha" uniqKey="Menon U" first="Usha" last="Menon">Usha Menon</name><affiliation><nlm:aff id="A199">Women's Cancer, UCL EGA Institute for Women's Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Harrington, Patricia" sort="Harrington, Patricia" uniqKey="Harrington P" first="Patricia" last="Harrington">Patricia Harrington</name><affiliation><nlm:aff id="A3">Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Lee, Alice W" sort="Lee, Alice W" uniqKey="Lee A" first="Alice W." last="Lee">Alice W. Lee</name><affiliation><nlm:aff id="A2">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H." last="Wu">Anna H. Wu</name><affiliation><nlm:aff id="A2">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Pearce, Celeste L" sort="Pearce, Celeste L" uniqKey="Pearce C" first="Celeste L." last="Pearce">Celeste L. Pearce</name><affiliation><nlm:aff id="A2">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Coetzee, Gerhard A" sort="Coetzee, Gerhard A" uniqKey="Coetzee G" first="Gerhard A." last="Coetzee">Gerhard A. Coetzee</name><affiliation><nlm:aff id="A12">Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Department of Urology, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Pike, Malcolm C" sort="Pike, Malcolm C" uniqKey="Pike M" first="Malcolm C." last="Pike">Malcolm C. Pike</name><affiliation><nlm:aff id="A2">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A200">Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Dansonka Mieszkowska, Agnieszka" sort="Dansonka Mieszkowska, Agnieszka" uniqKey="Dansonka Mieszkowska A" first="Agnieszka" last="Dansonka-Mieszkowska">Agnieszka Dansonka-Mieszkowska</name><affiliation><nlm:aff id="A201">Department of Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Timorek, Agnieszka" sort="Timorek, Agnieszka" uniqKey="Timorek A" first="Agnieszka" last="Timorek">Agnieszka Timorek</name><affiliation><nlm:aff id="A202">Department of Obstetrics, Gynecology and Oncology, IInd Faculty of Medicine, Warsaw Medical University and Brodnowski Hospital, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Rzepecka, Iwona K" sort="Rzepecka, Iwona K" uniqKey="Rzepecka I" first="Iwona K." last="Rzepecka">Iwona K. Rzepecka</name><affiliation><nlm:aff id="A201">Department of Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Kupryjanczyk, Jolanta" sort="Kupryjanczyk, Jolanta" uniqKey="Kupryjanczyk J" first="Jolanta" last="Kupryjanczyk">Jolanta Kupryjanczyk</name><affiliation><nlm:aff id="A201">Department of Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Freedman, Matt" sort="Freedman, Matt" uniqKey="Freedman M" first="Matt" last="Freedman">Matt Freedman</name><affiliation><nlm:aff id="A8">Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Noushmehr, Houtan" sort="Noushmehr, Houtan" uniqKey="Noushmehr H" first="Houtan" last="Noushmehr">Houtan Noushmehr</name><affiliation><nlm:aff id="A9">Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Brazil</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Center For Cell Based Therapy, Monte Alegre, Ribeirão Preto, SP, Brazil</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Center for Integrative Systems Biology, Monte Alegre, Ribeirão Preto, SP, Brazil</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><nlm:aff id="A91">Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A88">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A89">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Gayther, Simon" sort="Gayther, Simon" uniqKey="Gayther S" first="Simon" last="Gayther">Simon Gayther</name><affiliation><nlm:aff id="A2">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul P" sort="Pharoah, Paul P" uniqKey="Pharoah P" first="Paul P." last="Pharoah">Paul P. Pharoah</name><affiliation><nlm:aff id="A3">Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A4">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia</nlm:aff></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Auranen, A" uniqKey="Auranen A">A Auranen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stratton, Jf" uniqKey="Stratton J">JF Stratton</name></author><author><name sortKey="Pharoah, P" uniqKey="Pharoah P">P Pharoah</name></author><author><name sortKey="Smith, Sk" uniqKey="Smith S">SK Smith</name></author><author><name sortKey="Easton, D" uniqKey="Easton D">D Easton</name></author><author><name sortKey="Ponder, Ba" uniqKey="Ponder B">BA Ponder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jervis, S" uniqKey="Jervis S">S Jervis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bolton, Kl" uniqKey="Bolton K">KL Bolton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goode, El" uniqKey="Goode E">EL Goode</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, H" uniqKey="Song H">H Song</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pharoah, Pd" uniqKey="Pharoah P">PD Pharoah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Permuth Wey, J" uniqKey="Permuth Wey J">J Permuth-Wey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bojesen, Se" uniqKey="Bojesen S">SE Bojesen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Couch, Fj" uniqKey="Couch F">FJ Couch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramus, Sj" uniqKey="Ramus S">SJ Ramus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramus, Sj" uniqKey="Ramus S">SJ Ramus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Couch, Fj" uniqKey="Couch F">FJ Couch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bolton, Kl" uniqKey="Bolton K">KL Bolton</name></author><author><name sortKey="Ganda, C" uniqKey="Ganda C">C Ganda</name></author><author><name sortKey="Berchuck, A" uniqKey="Berchuck A">A Berchuck</name></author><author><name sortKey="Pharaoh, Pd" uniqKey="Pharaoh P">PD Pharaoh</name></author><author><name sortKey="Gayther, Sa" uniqKey="Gayther S">SA Gayther</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chenevix Trench, G" uniqKey="Chenevix Trench G">G Chenevix-Trench</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gaudet, Mm" uniqKey="Gaudet M">MM Gaudet</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Barnes, Dr" uniqKey="Barnes D">DR Barnes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bourguignon, Ly" uniqKey="Bourguignon L">LY Bourguignon</name></author><author><name sortKey="Gilad, E" uniqKey="Gilad E">E Gilad</name></author><author><name sortKey="Rothman, K" uniqKey="Rothman K">K Rothman</name></author><author><name sortKey="Peyrollier, K" uniqKey="Peyrollier K">K Peyrollier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zuo, Y" uniqKey="Zuo Y">Y Zuo</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y Wu</name></author><author><name sortKey="Chakraborty, C" uniqKey="Chakraborty C">C Chakraborty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pagliardini, L" uniqKey="Pagliardini L">L Pagliardini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pearce, Cl" uniqKey="Pearce C">CL Pearce</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tomaselli, S" uniqKey="Tomaselli S">S Tomaselli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parma, P" uniqKey="Parma P">P Parma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tomizuka, K" uniqKey="Tomizuka K">K Tomizuka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Ganck, A" uniqKey="De Ganck A">A De Ganck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jing, L" uniqKey="Jing L">L Jing</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, F" uniqKey="Lin F">F Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanchez Carbayo, M" uniqKey="Sanchez Carbayo M">M Sanchez-Carbayo</name></author><author><name sortKey="Schwarz, K" uniqKey="Schwarz K">K Schwarz</name></author><author><name sortKey="Charytonowicz, E" uniqKey="Charytonowicz E">E Charytonowicz</name></author><author><name sortKey="Cordon Cardo, C" uniqKey="Cordon Cardo C">C Cordon-Cardo</name></author><author><name sortKey="Mundel, P" uniqKey="Mundel P">P Mundel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, Yp" uniqKey="Yu Y">YP Yu</name></author><author><name sortKey="Luo, Jh" uniqKey="Luo J">JH Luo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amundadottir, L" uniqKey="Amundadottir L">L Amundadottir</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rummel, S" uniqKey="Rummel S">S Rummel</name></author><author><name sortKey="Shriver, Cd" uniqKey="Shriver C">CD Shriver</name></author><author><name sortKey="Ellsworth, Re" uniqKey="Ellsworth R">RE Ellsworth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poole, Em" uniqKey="Poole E">EM Poole</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sikdar, N" uniqKey="Sikdar N">N Sikdar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bell, Dw" uniqKey="Bell D">DW Bell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Ky" uniqKey="Lee K">KY Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wacholder, S" uniqKey="Wacholder S">S Wacholder</name></author><author><name sortKey="Han, Ss" uniqKey="Han S">SS Han</name></author><author><name sortKey="Weinberg, Cr" uniqKey="Weinberg C">CR Weinberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hnisz, D" uniqKey="Hnisz D">D Hnisz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Permuth Wey, J" uniqKey="Permuth Wey J">J Permuth-Wey</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Delaneau, O" uniqKey="Delaneau O">O Delaneau</name></author><author><name sortKey="Marchini, J" uniqKey="Marchini J">J Marchini</name></author><author><name sortKey="Zagury, Jf" uniqKey="Zagury J">JF Zagury</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Howie, Bn" uniqKey="Howie B">BN Howie</name></author><author><name sortKey="Donnelly, P" uniqKey="Donnelly P">P Donnelly</name></author><author><name sortKey="Marchini, J" uniqKey="Marchini J">J Marchini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Antoniou, Ac" uniqKey="Antoniou A">AC Antoniou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Antoniou, Ac" uniqKey="Antoniou A">AC Antoniou</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Udler, Ms" uniqKey="Udler M">MS Udler</name></author><author><name sortKey="Tyrer, J" uniqKey="Tyrer J">J Tyrer</name></author><author><name sortKey="Easton, Df" uniqKey="Easton D">DF Easton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reumers, J" uniqKey="Reumers J">J Reumers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Conde, L" uniqKey="Conde L">L Conde</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mavaddat, N" uniqKey="Mavaddat N">N Mavaddat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lakhani, Sr" uniqKey="Lakhani S">SR Lakhani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rubin, Sc" uniqKey="Rubin S">SC Rubin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maehle, L" uniqKey="Maehle L">L Maehle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shaw, Pa" uniqKey="Shaw P">PA Shaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Willer, Cj" uniqKey="Willer C">CJ Willer</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Abecasis, Gr" uniqKey="Abecasis G">GR Abecasis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Nf" uniqKey="Li N">NF Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fotheringham, S" uniqKey="Fotheringham S">S Fotheringham</name></author><author><name sortKey="Levanon, K" uniqKey="Levanon K">K Levanon</name></author><author><name sortKey="Drapkin, R" uniqKey="Drapkin R">R Drapkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Forbes, Sa" uniqKey="Forbes S">SA Forbes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, J" uniqKey="Gao J">J Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cerami, E" uniqKey="Cerami E">E Cerami</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lawrenson, K" uniqKey="Lawrenson K">K Lawrenson</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id><journal-id journal-id-type="pubmed-jr-id">2419</journal-id><journal-id journal-id-type="nlm-ta">Nat Genet</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Genet.</journal-id><journal-title-group><journal-title>Nature genetics</journal-title></journal-title-group><issn pub-type="ppub">1061-4036</issn><issn pub-type="epub">1546-1718</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25581431</article-id><article-id pub-id-type="pmc">4445140</article-id><article-id pub-id-type="doi">10.1038/ng.3185</article-id><article-id pub-id-type="manuscript">NIHMS647338</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Identification of six new susceptibility loci for invasive epithelial ovarian cancer</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Kuchenbaecker</surname><given-names>Karoline B.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Ramus</surname><given-names>Susan J.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Tyrer</surname><given-names>Jonathan</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Andrew</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Shen</surname><given-names>Howard C.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Beesley</surname><given-names>Jonathan</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Lawrenson</surname><given-names>Kate</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>McGuffog</surname><given-names>Lesley</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Healey</surname><given-names>Sue</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Janet M.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Spindler</surname><given-names>Tassja J.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Lin</surname><given-names>Yvonne G.</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Pejovic</surname><given-names>Tanja</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Bean</surname><given-names>Yukie</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Qiyuan</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Coetzee</surname><given-names>Simon</given-names></name><xref ref-type="aff" rid="A9">9</xref><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Hazelett</surname><given-names>Dennis</given-names></name><xref ref-type="aff" rid="A12">12</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Miron</surname><given-names>Alexander</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Southey</surname><given-names>Melissa</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Terry</surname><given-names>Mary Beth</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Goldgar</surname><given-names>David E.</given-names></name><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Buys</surname><given-names>Saundra S.</given-names></name><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Janavicius</surname><given-names>Ramunas</given-names></name><xref ref-type="aff" rid="A19">19</xref><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Dorfling</surname><given-names>Cecilia M.</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>van Rensburg</surname><given-names>Elizabeth J.</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Neuhausen</surname><given-names>Susan L.</given-names></name><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Ding</surname><given-names>Yuan Chun</given-names></name><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Hansen</surname><given-names>Thomas V. O.</given-names></name><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Jønson</surname><given-names>Lars</given-names></name><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Gerdes</surname><given-names>Anne-Marie</given-names></name><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Ejlertsen</surname><given-names>Bent</given-names></name><xref ref-type="aff" rid="A25">25</xref></contrib><contrib contrib-type="author"><name><surname>Barrowdale</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Dennis</surname><given-names>Joe</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Benitez</surname><given-names>Javier</given-names></name><xref ref-type="aff" rid="A26">26</xref><xref ref-type="aff" rid="A27">27</xref><xref ref-type="aff" rid="A28">28</xref></contrib><contrib contrib-type="author"><name><surname>Osorio</surname><given-names>Ana</given-names></name><xref ref-type="aff" rid="A26">26</xref><xref ref-type="aff" rid="A28">28</xref></contrib><contrib contrib-type="author"><name><surname>Garcia</surname><given-names>Maria Jose</given-names></name><xref ref-type="aff" rid="A26">26</xref><xref ref-type="aff" rid="A28">28</xref></contrib><contrib contrib-type="author"><name><surname>Komenaka</surname><given-names>Ian</given-names></name><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Weitzel</surname><given-names>Jeffrey N.</given-names></name><xref ref-type="aff" rid="A30">30</xref></contrib><contrib contrib-type="author"><name><surname>Ganschow</surname><given-names>Pamela</given-names></name><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>Peterlongo</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Bernard</surname><given-names>Loris</given-names></name><xref ref-type="aff" rid="A33">33</xref><xref ref-type="aff" rid="A34">34</xref></contrib><contrib contrib-type="author"><name><surname>Viel</surname><given-names>Alessandra</given-names></name><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Bonanni</surname><given-names>Bernardo</given-names></name><xref ref-type="aff" rid="A36">36</xref></contrib><contrib contrib-type="author"><name><surname>Peissel</surname><given-names>Bernard</given-names></name><xref ref-type="aff" rid="A37">37</xref></contrib><contrib contrib-type="author"><name><surname>Manoukian</surname><given-names>Siranoush</given-names></name><xref ref-type="aff" rid="A37">37</xref></contrib><contrib contrib-type="author"><name><surname>Radice</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Papi</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="A39">39</xref></contrib><contrib contrib-type="author"><name><surname>Ottini</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="A40">40</xref></contrib><contrib contrib-type="author"><name><surname>Fostira</surname><given-names>Florentia</given-names></name><xref ref-type="aff" rid="A41">41</xref></contrib><contrib contrib-type="author"><name><surname>Konstantopoulou</surname><given-names>Irene</given-names></name><xref ref-type="aff" rid="A41">41</xref></contrib><contrib contrib-type="author"><name><surname>Garber</surname><given-names>Judy</given-names></name><xref ref-type="aff" rid="A42">42</xref></contrib><contrib contrib-type="author"><name><surname>Frost</surname><given-names>Debra</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Perkins</surname><given-names>Jo</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Platte</surname><given-names>Radka</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ellis</surname><given-names>Steve</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><collab>EMBRACE</collab><xref ref-type="author-notes" rid="FN1">43</xref></contrib><contrib contrib-type="author"><name><surname>Godwin</surname><given-names>Andrew K.</given-names></name><xref ref-type="aff" rid="A43">44</xref></contrib><contrib contrib-type="author"><name><surname>Schmutzler</surname><given-names>Rita Katharina</given-names></name><xref ref-type="aff" rid="A44">45</xref><xref ref-type="aff" rid="A45">46</xref><xref ref-type="aff" rid="A46">47</xref><xref ref-type="author-notes" rid="FN2">48</xref></contrib><contrib contrib-type="author"><name><surname>Meindl</surname><given-names>Alfons</given-names></name><xref ref-type="aff" rid="A47">49</xref></contrib><contrib contrib-type="author"><name><surname>Engel</surname><given-names>Christoph</given-names></name><xref ref-type="aff" rid="A48">50</xref></contrib><contrib contrib-type="author"><name><surname>Sutter</surname><given-names>Christian</given-names></name><xref ref-type="aff" rid="A49">51</xref></contrib><contrib contrib-type="author"><name><surname>Sinilnikova</surname><given-names>Olga M.</given-names></name><xref ref-type="aff" rid="A50">52</xref><xref ref-type="aff" rid="A51">53</xref></contrib><contrib contrib-type="author"><collab>GEMO Study Collaborators</collab><xref ref-type="author-notes" rid="FN1">43</xref></contrib><contrib contrib-type="author"><name><surname>Damiola</surname><given-names>Francesca</given-names></name><xref ref-type="aff" rid="A50">52</xref></contrib><contrib contrib-type="author"><name><surname>Mazoyer</surname><given-names>Sylvie</given-names></name><xref ref-type="aff" rid="A50">52</xref></contrib><contrib contrib-type="author"><name><surname>Stoppa-Lyonnet</surname><given-names>Dominique</given-names></name><xref ref-type="aff" rid="A52">54</xref><xref ref-type="aff" rid="A53">55</xref><xref ref-type="aff" rid="A54">56</xref></contrib><contrib contrib-type="author"><name><surname>Claes</surname><given-names>Kathleen</given-names></name><xref ref-type="aff" rid="A55">57</xref></contrib><contrib contrib-type="author"><name><surname>De Leeneer</surname><given-names>Kim</given-names></name><xref ref-type="aff" rid="A55">57</xref></contrib><contrib contrib-type="author"><name><surname>Kirk</surname><given-names>Judy</given-names></name><xref ref-type="aff" rid="A56">58</xref></contrib><contrib contrib-type="author"><name><surname>Rodriguez</surname><given-names>Gustavo C.</given-names></name><xref ref-type="aff" rid="A57">59</xref></contrib><contrib contrib-type="author"><name><surname>Piedmonte</surname><given-names>Marion</given-names></name><xref ref-type="aff" rid="A58">60</xref></contrib><contrib contrib-type="author"><name><surname>O'Malley</surname><given-names>David M.</given-names></name><xref ref-type="aff" rid="A59">61</xref></contrib><contrib contrib-type="author"><name><surname>de la Hoya</surname><given-names>Miguel</given-names></name><xref ref-type="aff" rid="A60">62</xref></contrib><contrib contrib-type="author"><name><surname>Caldes</surname><given-names>Trinidad</given-names></name><xref ref-type="aff" rid="A60">62</xref></contrib><contrib contrib-type="author"><name><surname>Aittomäki</surname><given-names>Kristiina</given-names></name><xref ref-type="aff" rid="A61">63</xref></contrib><contrib contrib-type="author"><name><surname>Nevanlinna</surname><given-names>Heli</given-names></name><xref ref-type="aff" rid="A62">64</xref></contrib><contrib contrib-type="author"><name><surname>Collée</surname><given-names>J. Margriet</given-names></name><xref ref-type="aff" rid="A63">65</xref></contrib><contrib contrib-type="author"><name><surname>Rookus</surname><given-names>Matti A.</given-names></name><xref ref-type="aff" rid="A64">66</xref></contrib><contrib contrib-type="author"><name><surname>Oosterwijk</surname><given-names>Jan C.</given-names></name><xref ref-type="aff" rid="A65">67</xref></contrib><contrib contrib-type="author"><collab>Breast Cancer Family Registry</collab><xref ref-type="author-notes" rid="FN1">43</xref></contrib><contrib contrib-type="author"><name><surname>Tihomirova</surname><given-names>Laima</given-names></name><xref ref-type="aff" rid="A66">68</xref></contrib><contrib contrib-type="author"><name><surname>Tung</surname><given-names>Nadine</given-names></name><xref ref-type="aff" rid="A67">69</xref></contrib><contrib contrib-type="author"><name><surname>Hamann</surname><given-names>Ute</given-names></name><xref ref-type="aff" rid="A68">70</xref></contrib><contrib contrib-type="author"><name><surname>Isaacs</surname><given-names>Claudine</given-names></name><xref ref-type="aff" rid="A69">71</xref></contrib><contrib contrib-type="author"><name><surname>Tischkowitz</surname><given-names>Marc</given-names></name><xref ref-type="aff" rid="A70">72</xref></contrib><contrib contrib-type="author"><name><surname>Imyanitov</surname><given-names>Evgeny N.</given-names></name><xref ref-type="aff" rid="A71">73</xref></contrib><contrib contrib-type="author"><name><surname>Caligo</surname><given-names>Maria A.</given-names></name><xref ref-type="aff" rid="A72">74</xref></contrib><contrib contrib-type="author"><name><surname>Campbell</surname><given-names>Ian</given-names></name><xref ref-type="aff" rid="A73">75</xref></contrib><contrib contrib-type="author"><name><surname>Hogervorst</surname><given-names>Frans B.L.</given-names></name><xref ref-type="aff" rid="A74">76</xref></contrib><contrib contrib-type="author"><collab>HEBON</collab><xref ref-type="author-notes" rid="FN1">43</xref></contrib><contrib contrib-type="author"><name><surname>Olah</surname><given-names>Edith</given-names></name><xref ref-type="aff" rid="A75">77</xref></contrib><contrib contrib-type="author"><name><surname>Diez</surname><given-names>Orland</given-names></name><xref ref-type="aff" rid="A76">78</xref></contrib><contrib contrib-type="author"><name><surname>Blanco</surname><given-names>Ignacio</given-names></name><xref ref-type="aff" rid="A77">79</xref></contrib><contrib contrib-type="author"><name><surname>Brunet</surname><given-names>Joan</given-names></name><xref ref-type="aff" rid="A78">80</xref></contrib><contrib contrib-type="author"><name><surname>Lazaro</surname><given-names>Conxi</given-names></name><xref ref-type="aff" rid="A79">81</xref></contrib><contrib contrib-type="author"><name><surname>Pujana</surname><given-names>Miquel Angel</given-names></name><xref ref-type="aff" rid="A80">82</xref></contrib><contrib contrib-type="author"><name><surname>Jakubowska</surname><given-names>Anna</given-names></name><xref ref-type="aff" rid="A81">83</xref></contrib><contrib contrib-type="author"><name><surname>Gronwald</surname><given-names>Jacek</given-names></name><xref ref-type="aff" rid="A81">83</xref></contrib><contrib contrib-type="author"><name><surname>Lubinski</surname><given-names>Jan</given-names></name><xref ref-type="aff" rid="A81">83</xref></contrib><contrib contrib-type="author"><name><surname>Sukiennicki</surname><given-names>Grzegorz</given-names></name><xref ref-type="aff" rid="A81">83</xref></contrib><contrib contrib-type="author"><name><surname>Barkardottir</surname><given-names>Rosa B.</given-names></name><xref ref-type="aff" rid="A82">84</xref></contrib><contrib contrib-type="author"><name><surname>Plante</surname><given-names>Marie</given-names></name><xref ref-type="aff" rid="A83">85</xref></contrib><contrib contrib-type="author"><name><surname>Simard</surname><given-names>Jacques</given-names></name><xref ref-type="aff" rid="A84">86</xref></contrib><contrib contrib-type="author"><name><surname>Soucy</surname><given-names>Penny</given-names></name><xref ref-type="aff" rid="A84">86</xref></contrib><contrib contrib-type="author"><name><surname>Montagna</surname><given-names>Marco</given-names></name><xref ref-type="aff" rid="A85">87</xref></contrib><contrib contrib-type="author"><name><surname>Tognazzo</surname><given-names>Silvia</given-names></name><xref ref-type="aff" rid="A85">87</xref></contrib><contrib contrib-type="author"><name><surname>Teixeira</surname><given-names>Manuel R.</given-names></name><xref ref-type="aff" rid="A86">88</xref><xref ref-type="aff" rid="A87">89</xref></contrib><contrib contrib-type="author"><collab>KConFab Investigators</collab><xref ref-type="author-notes" rid="FN1">43</xref></contrib><contrib contrib-type="author"><name><surname>Pankratz</surname><given-names>Vernon S.</given-names></name><xref ref-type="aff" rid="A88">90</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Xianshu</given-names></name><xref ref-type="aff" rid="A89">91</xref></contrib><contrib contrib-type="author"><name><surname>Lindor</surname><given-names>Noralane</given-names></name><xref ref-type="aff" rid="A88">90</xref></contrib><contrib contrib-type="author"><name><surname>Szabo</surname><given-names>Csilla I.</given-names></name><xref ref-type="aff" rid="A90">92</xref></contrib><contrib contrib-type="author"><name><surname>Kauff</surname><given-names>Noah</given-names></name><xref ref-type="aff" rid="A91">93</xref></contrib><contrib contrib-type="author"><name><surname>Vijai</surname><given-names>Joseph</given-names></name><xref ref-type="aff" rid="A91">93</xref></contrib><contrib contrib-type="author"><name><surname>Aghajanian</surname><given-names>Carol A.</given-names></name><xref ref-type="aff" rid="A91">93</xref></contrib><contrib contrib-type="author"><name><surname>Pfeiler</surname><given-names>Georg</given-names></name><xref ref-type="aff" rid="A92">94</xref></contrib><contrib contrib-type="author"><name><surname>Berger</surname><given-names>Andreas</given-names></name><xref ref-type="aff" rid="A92">94</xref></contrib><contrib contrib-type="author"><name><surname>Singer</surname><given-names>Christian F.</given-names></name><xref ref-type="aff" rid="A92">94</xref></contrib><contrib contrib-type="author"><name><surname>Tea</surname><given-names>Muy-Kheng</given-names></name><xref ref-type="aff" rid="A92">94</xref></contrib><contrib contrib-type="author"><name><surname>Phelan</surname><given-names>Catherine M.</given-names></name><xref ref-type="aff" rid="A93">95</xref></contrib><contrib contrib-type="author"><name><surname>Greene</surname><given-names>Mark H.</given-names></name><xref ref-type="aff" rid="A94">96</xref></contrib><contrib contrib-type="author"><name><surname>Mai</surname><given-names>Phuong L.</given-names></name><xref ref-type="aff" rid="A94">96</xref></contrib><contrib contrib-type="author"><name><surname>Rennert</surname><given-names>Gad</given-names></name><xref ref-type="aff" rid="A95">97</xref></contrib><contrib contrib-type="author"><name><surname>Mulligan</surname><given-names>Anna Marie</given-names></name><xref ref-type="aff" rid="A96">98</xref><xref ref-type="aff" rid="A97">99</xref></contrib><contrib contrib-type="author"><name><surname>Tchatchou</surname><given-names>Sandrine</given-names></name><xref ref-type="aff" rid="A98">100</xref></contrib><contrib contrib-type="author"><name><surname>Andrulis</surname><given-names>Irene L.</given-names></name><xref ref-type="aff" rid="A96">98</xref><xref ref-type="aff" rid="A99">101</xref></contrib><contrib contrib-type="author"><name><surname>Glendon</surname><given-names>Gord</given-names></name><xref ref-type="aff" rid="A98">100</xref></contrib><contrib contrib-type="author"><name><surname>Toland</surname><given-names>Amanda Ewart</given-names></name><xref ref-type="aff" rid="A100">102</xref></contrib><contrib contrib-type="author"><name><surname>Jensen</surname><given-names>Uffe Birk</given-names></name><xref ref-type="aff" rid="A101">103</xref></contrib><contrib contrib-type="author"><name><surname>Kruse</surname><given-names>Torben A.</given-names></name><xref ref-type="aff" rid="A102">104</xref></contrib><contrib contrib-type="author"><name><surname>Thomassen</surname><given-names>Mads</given-names></name><xref ref-type="aff" rid="A102">104</xref></contrib><contrib contrib-type="author"><name><surname>Bojesen</surname><given-names>Anders</given-names></name><xref ref-type="aff" rid="A103">105</xref></contrib><contrib contrib-type="author"><name><surname>Zidan</surname><given-names>Jamal</given-names></name><xref ref-type="aff" rid="A104">106</xref></contrib><contrib contrib-type="author"><name><surname>Friedman</surname><given-names>Eitan</given-names></name><xref ref-type="aff" rid="A105">107</xref></contrib><contrib contrib-type="author"><name><surname>Laitman</surname><given-names>Yael</given-names></name><xref ref-type="aff" rid="A105">107</xref></contrib><contrib contrib-type="author"><name><surname>Soller</surname><given-names>Maria</given-names></name><xref ref-type="aff" rid="A106">108</xref></contrib><contrib contrib-type="author"><name><surname>Liljegren</surname><given-names>Annelie</given-names></name><xref ref-type="aff" rid="A107">109</xref></contrib><contrib contrib-type="author"><name><surname>Arver</surname><given-names>Brita</given-names></name><xref ref-type="aff" rid="A107">109</xref></contrib><contrib contrib-type="author"><name><surname>Einbeigi</surname><given-names>Zakaria</given-names></name><xref ref-type="aff" rid="A108">110</xref></contrib><contrib contrib-type="author"><name><surname>Stenmark-Askmalm</surname><given-names>Marie</given-names></name><xref ref-type="aff" rid="A109">111</xref></contrib><contrib contrib-type="author"><name><surname>Olopade</surname><given-names>Olufunmilayo I.</given-names></name><xref ref-type="aff" rid="A110">112</xref></contrib><contrib contrib-type="author"><name><surname>Nussbaum</surname><given-names>Robert L.</given-names></name><xref ref-type="aff" rid="A111">113</xref></contrib><contrib contrib-type="author"><name><surname>Rebbeck</surname><given-names>Timothy R.</given-names></name><xref ref-type="aff" rid="A112">114</xref></contrib><contrib contrib-type="author"><name><surname>Nathanson</surname><given-names>Katherine L.</given-names></name><xref ref-type="aff" rid="A112">114</xref></contrib><contrib contrib-type="author"><name><surname>Domchek</surname><given-names>Susan M.</given-names></name><xref ref-type="aff" rid="A112">114</xref></contrib><contrib contrib-type="author"><name><surname>Lu</surname><given-names>Karen H.</given-names></name><xref ref-type="aff" rid="A113">115</xref></contrib><contrib contrib-type="author"><name><surname>Karlan</surname><given-names>Beth Y.</given-names></name><xref ref-type="aff" rid="A114">116</xref></contrib><contrib contrib-type="author"><name><surname>Walsh</surname><given-names>Christine</given-names></name><xref ref-type="aff" rid="A114">116</xref></contrib><contrib contrib-type="author"><name><surname>Lester</surname><given-names>Jenny</given-names></name><xref ref-type="aff" rid="A114">116</xref></contrib><contrib contrib-type="author"><collab>Australian Cancer Study (Ovarian Cancer Investigators)</collab><xref ref-type="author-notes" rid="FN1">43</xref></contrib><contrib contrib-type="author"><collab>Australian Ovarian Cancer Study Group</collab><xref ref-type="author-notes" rid="FN1">43</xref></contrib><contrib contrib-type="author"><name><surname>Hein</surname><given-names>Alexander</given-names></name><xref ref-type="aff" rid="A115">117</xref></contrib><contrib contrib-type="author"><name><surname>Ekici</surname><given-names>Arif B.</given-names></name><xref ref-type="aff" rid="A116">118</xref></contrib><contrib contrib-type="author"><name><surname>Beckmann</surname><given-names>Matthias W.</given-names></name><xref ref-type="aff" rid="A115">117</xref></contrib><contrib contrib-type="author"><name><surname>Fasching</surname><given-names>Peter A.</given-names></name><xref ref-type="aff" rid="A115">117</xref><xref ref-type="aff" rid="A117">119</xref></contrib><contrib contrib-type="author"><name><surname>Lambrechts</surname><given-names>Diether</given-names></name><xref ref-type="aff" rid="A118">120</xref><xref ref-type="aff" rid="A119">121</xref></contrib><contrib contrib-type="author"><name><surname>Nieuwenhuysen</surname><given-names>Els Van</given-names></name><xref ref-type="aff" rid="A120">122</xref></contrib><contrib contrib-type="author"><name><surname>Vergote</surname><given-names>Ignace</given-names></name><xref ref-type="aff" rid="A120">122</xref></contrib><contrib contrib-type="author"><name><surname>Lambrechts</surname><given-names>Sandrina</given-names></name><xref ref-type="aff" rid="A120">122</xref></contrib><contrib contrib-type="author"><name><surname>Dicks</surname><given-names>Ed</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Doherty</surname><given-names>Jennifer A.</given-names></name><xref ref-type="aff" rid="A121">123</xref></contrib><contrib contrib-type="author"><name><surname>Wicklund</surname><given-names>Kristine G.</given-names></name><xref ref-type="aff" rid="A122">124</xref></contrib><contrib contrib-type="author"><name><surname>Rossing</surname><given-names>Mary Anne</given-names></name><xref ref-type="aff" rid="A122">124</xref><xref ref-type="aff" rid="A123">125</xref></contrib><contrib contrib-type="author"><name><surname>Rudolph</surname><given-names>Anja</given-names></name><xref ref-type="aff" rid="A124">126</xref></contrib><contrib contrib-type="author"><name><surname>Chang-Claude</surname><given-names>Jenny</given-names></name><xref ref-type="aff" rid="A124">126</xref></contrib><contrib contrib-type="author"><name><surname>Wang-Gohrke</surname><given-names>Shan</given-names></name><xref ref-type="aff" rid="A125">127</xref></contrib><contrib contrib-type="author"><name><surname>Eilber</surname><given-names>Ursula</given-names></name><xref ref-type="aff" rid="A124">126</xref></contrib><contrib contrib-type="author"><name><surname>Moysich</surname><given-names>Kirsten B.</given-names></name><xref ref-type="aff" rid="A126">128</xref></contrib><contrib contrib-type="author"><name><surname>Odunsi</surname><given-names>Kunle</given-names></name><xref ref-type="aff" rid="A127">129</xref></contrib><contrib contrib-type="author"><name><surname>Sucheston-Campbell</surname><given-names>Lara</given-names></name><xref ref-type="aff" rid="A126">128</xref></contrib><contrib contrib-type="author"><name><surname>Lele</surname><given-names>Shashi</given-names></name><xref ref-type="aff" rid="A126">128</xref></contrib><contrib contrib-type="author"><name><surname>Wilkens</surname><given-names>Lynne R.</given-names></name><xref ref-type="aff" rid="A128">130</xref></contrib><contrib contrib-type="author"><name><surname>Goodman</surname><given-names>Marc T.</given-names></name><xref ref-type="aff" rid="A129">131</xref><xref ref-type="aff" rid="A130">132</xref></contrib><contrib contrib-type="author"><name><surname>Thompson</surname><given-names>Pamela J.</given-names></name><xref ref-type="aff" rid="A129">131</xref><xref ref-type="aff" rid="A130">132</xref></contrib><contrib contrib-type="author"><name><surname>Shvetsov</surname><given-names>Yurii B.</given-names></name><xref ref-type="aff" rid="A128">130</xref></contrib><contrib contrib-type="author"><name><surname>Runnebaum</surname><given-names>Ingo B.</given-names></name><xref ref-type="aff" rid="A131">133</xref></contrib><contrib contrib-type="author"><name><surname>Dürst</surname><given-names>Matthias</given-names></name><xref ref-type="aff" rid="A131">133</xref></contrib><contrib contrib-type="author"><name><surname>Hillemanns</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="A132">134</xref></contrib><contrib contrib-type="author"><name><surname>Dörk</surname><given-names>Thilo</given-names></name><xref ref-type="aff" rid="A133">135</xref></contrib><contrib contrib-type="author"><name><surname>Antonenkova</surname><given-names>Natalia</given-names></name><xref ref-type="aff" rid="A134">136</xref></contrib><contrib contrib-type="author"><name><surname>Bogdanova</surname><given-names>Natalia</given-names></name><xref ref-type="aff" rid="A133">135</xref></contrib><contrib contrib-type="author"><name><surname>Leminen</surname><given-names>Arto</given-names></name><xref ref-type="aff" rid="A62">64</xref></contrib><contrib contrib-type="author"><name><surname>Pelttari</surname><given-names>Liisa M.</given-names></name><xref ref-type="aff" rid="A62">64</xref></contrib><contrib contrib-type="author"><name><surname>Butzow</surname><given-names>Ralf</given-names></name><xref ref-type="aff" rid="A62">64</xref><xref ref-type="aff" rid="A135">137</xref></contrib><contrib contrib-type="author"><name><surname>Modugno</surname><given-names>Francesmary</given-names></name><xref ref-type="aff" rid="A136">138</xref><xref ref-type="aff" rid="A137">139</xref><xref ref-type="aff" rid="A138">140</xref><xref ref-type="aff" rid="A139">141</xref></contrib><contrib contrib-type="author"><name><surname>Kelley</surname><given-names>Joseph L.</given-names></name><xref ref-type="aff" rid="A137">139</xref></contrib><contrib contrib-type="author"><name><surname>Edwards</surname><given-names>Robert P.</given-names></name><xref ref-type="aff" rid="A137">139</xref><xref ref-type="aff" rid="A138">140</xref></contrib><contrib contrib-type="author"><name><surname>Ness</surname><given-names>Roberta B.</given-names></name><xref ref-type="aff" rid="A140">142</xref></contrib><contrib contrib-type="author"><name><surname>du Bois</surname><given-names>Andreas</given-names></name><xref ref-type="aff" rid="A141">143</xref><xref ref-type="aff" rid="A142">144</xref></contrib><contrib contrib-type="author"><name><surname>Heitz</surname><given-names>Florian</given-names></name><xref ref-type="aff" rid="A141">143</xref><xref ref-type="aff" rid="A142">144</xref></contrib><contrib contrib-type="author"><name><surname>Schwaab</surname><given-names>Ira</given-names></name><xref ref-type="aff" rid="A143">145</xref></contrib><contrib contrib-type="author"><name><surname>Harter</surname><given-names>Philipp</given-names></name><xref ref-type="aff" rid="A141">143</xref><xref ref-type="aff" rid="A142">144</xref></contrib><contrib contrib-type="author"><name><surname>Matsuo</surname><given-names>Keitaro</given-names></name><xref ref-type="aff" rid="A144">146</xref></contrib><contrib contrib-type="author"><name><surname>Hosono</surname><given-names>Satoyo</given-names></name><xref ref-type="aff" rid="A145">147</xref></contrib><contrib contrib-type="author"><name><surname>Orsulic</surname><given-names>Sandra</given-names></name><xref ref-type="aff" rid="A114">116</xref></contrib><contrib contrib-type="author"><name><surname>Jensen</surname><given-names>Allan</given-names></name><xref ref-type="aff" rid="A146">148</xref></contrib><contrib contrib-type="author"><name><surname>Kjaer</surname><given-names>Susanne Kruger</given-names></name><xref ref-type="aff" rid="A146">148</xref><xref ref-type="aff" rid="A147">149</xref></contrib><contrib contrib-type="author"><name><surname>Hogdall</surname><given-names>Estrid</given-names></name><xref ref-type="aff" rid="A146">148</xref><xref ref-type="aff" rid="A148">150</xref></contrib><contrib contrib-type="author"><name><surname>Hasmad</surname><given-names>Hanis Nazihah</given-names></name><xref ref-type="aff" rid="A149">151</xref></contrib><contrib contrib-type="author"><name><surname>Noor Azmi</surname><given-names>Mat Adenan</given-names></name><xref ref-type="aff" rid="A150">152</xref></contrib><contrib contrib-type="author"><name><surname>Teo</surname><given-names>Soo-Hwang</given-names></name><xref ref-type="aff" rid="A149">151</xref><xref ref-type="aff" rid="A151">153</xref></contrib><contrib contrib-type="author"><name><surname>Woo</surname><given-names>Yin-Ling</given-names></name><xref ref-type="aff" rid="A150">152</xref><xref ref-type="aff" rid="A151">153</xref></contrib><contrib contrib-type="author"><name><surname>Fridley</surname><given-names>Brooke L.</given-names></name><xref ref-type="aff" rid="A152">154</xref></contrib><contrib contrib-type="author"><name><surname>Goode</surname><given-names>Ellen L.</given-names></name><xref ref-type="aff" rid="A88">90</xref></contrib><contrib contrib-type="author"><name><surname>Cunningham</surname><given-names>Julie M.</given-names></name><xref ref-type="aff" rid="A89">91</xref></contrib><contrib contrib-type="author"><name><surname>Vierkant</surname><given-names>Robert A.</given-names></name><xref ref-type="aff" rid="A153">155</xref></contrib><contrib contrib-type="author"><name><surname>Bruinsma</surname><given-names>Fiona</given-names></name><xref ref-type="aff" rid="A154">156</xref></contrib><contrib contrib-type="author"><name><surname>Giles</surname><given-names>Graham G.</given-names></name><xref ref-type="aff" rid="A154">156</xref></contrib><contrib contrib-type="author"><name><surname>Liang</surname><given-names>Dong</given-names></name><xref ref-type="aff" rid="A155">157</xref></contrib><contrib contrib-type="author"><name><surname>Hildebrandt</surname><given-names>Michelle A.T.</given-names></name><xref ref-type="aff" rid="A156">158</xref></contrib><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Xifeng</given-names></name><xref ref-type="aff" rid="A156">158</xref></contrib><contrib contrib-type="author"><name><surname>Levine</surname><given-names>Douglas A.</given-names></name><xref ref-type="aff" rid="A157">159</xref></contrib><contrib contrib-type="author"><name><surname>Bisogna</surname><given-names>Maria</given-names></name><xref ref-type="aff" rid="A157">159</xref></contrib><contrib contrib-type="author"><name><surname>Berchuck</surname><given-names>Andrew</given-names></name><xref ref-type="aff" rid="A158">160</xref></contrib><contrib contrib-type="author"><name><surname>Iversen</surname><given-names>Edwin S.</given-names></name><xref ref-type="aff" rid="A159">161</xref></contrib><contrib contrib-type="author"><name><surname>Schildkraut</surname><given-names>Joellen M.</given-names></name><xref ref-type="aff" rid="A160">162</xref><xref ref-type="aff" rid="A161">163</xref></contrib><contrib contrib-type="author"><name><surname>Concannon</surname><given-names>Patrick</given-names></name><xref ref-type="aff" rid="A162">164</xref><xref ref-type="aff" rid="A163">165</xref></contrib><contrib contrib-type="author"><name><surname>Weber</surname><given-names>Rachel Palmieri</given-names></name><xref ref-type="aff" rid="A161">163</xref></contrib><contrib contrib-type="author"><name><surname>Cramer</surname><given-names>Daniel W.</given-names></name><xref ref-type="aff" rid="A164">166</xref><xref ref-type="aff" rid="A165">167</xref></contrib><contrib contrib-type="author"><name><surname>Terry</surname><given-names>Kathryn L.</given-names></name><xref ref-type="aff" rid="A164">166</xref><xref ref-type="aff" rid="A165">167</xref></contrib><contrib contrib-type="author"><name><surname>Poole</surname><given-names>Elizabeth M.</given-names></name><xref ref-type="aff" rid="A166">168</xref><xref ref-type="aff" rid="A167">169</xref></contrib><contrib contrib-type="author"><name><surname>Tworoger</surname><given-names>Shelley S.</given-names></name><xref ref-type="aff" rid="A166">168</xref><xref ref-type="aff" rid="A167">169</xref></contrib><contrib contrib-type="author"><name><surname>Bandera</surname><given-names>Elisa V.</given-names></name><xref ref-type="aff" rid="A168">170</xref></contrib><contrib contrib-type="author"><name><surname>Orlow</surname><given-names>Irene</given-names></name><xref ref-type="aff" rid="A169">171</xref></contrib><contrib contrib-type="author"><name><surname>Olson</surname><given-names>Sara H.</given-names></name><xref ref-type="aff" rid="A169">171</xref></contrib><contrib contrib-type="author"><name><surname>Krakstad</surname><given-names>Camilla</given-names></name><xref ref-type="aff" rid="A170">172</xref><xref ref-type="aff" rid="A171">173</xref></contrib><contrib contrib-type="author"><name><surname>Salvesen</surname><given-names>Helga B.</given-names></name><xref ref-type="aff" rid="A170">172</xref><xref ref-type="aff" rid="A171">173</xref></contrib><contrib contrib-type="author"><name><surname>Tangen</surname><given-names>Ingvild L.</given-names></name><xref ref-type="aff" rid="A170">172</xref><xref ref-type="aff" rid="A171">173</xref></contrib><contrib contrib-type="author"><name><surname>Bjorge</surname><given-names>Line</given-names></name><xref ref-type="aff" rid="A170">172</xref><xref ref-type="aff" rid="A171">173</xref></contrib><contrib contrib-type="author"><name><surname>van Altena</surname><given-names>Anne M.</given-names></name><xref ref-type="aff" rid="A172">174</xref></contrib><contrib contrib-type="author"><name><surname>Aben</surname><given-names>Katja K.H.</given-names></name><xref ref-type="aff" rid="A173">175</xref><xref ref-type="aff" rid="A174">176</xref></contrib><contrib contrib-type="author"><name><surname>Kiemeney</surname><given-names>Lambertus A.</given-names></name><xref ref-type="aff" rid="A174">176</xref><xref ref-type="aff" rid="A175">177</xref></contrib><contrib contrib-type="author"><name><surname>Massuger</surname><given-names>Leon F.A.G.</given-names></name><xref ref-type="aff" rid="A172">174</xref></contrib><contrib contrib-type="author"><name><surname>Kellar</surname><given-names>Melissa</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Brooks-Wilson</surname><given-names>Angela</given-names></name><xref ref-type="aff" rid="A176">178</xref><xref ref-type="aff" rid="A177">179</xref></contrib><contrib contrib-type="author"><name><surname>Kelemen</surname><given-names>Linda E.</given-names></name><xref ref-type="aff" rid="A178">180</xref></contrib><contrib contrib-type="author"><name><surname>Cook</surname><given-names>Linda S.</given-names></name><xref ref-type="aff" rid="A179">181</xref></contrib><contrib contrib-type="author"><name><surname>Le</surname><given-names>Nhu D.</given-names></name><xref ref-type="aff" rid="A180">182</xref></contrib><contrib contrib-type="author"><name><surname>Cybulski</surname><given-names>Cezary</given-names></name><xref ref-type="aff" rid="A181">183</xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Hannah</given-names></name><xref ref-type="aff" rid="A182">184</xref></contrib><contrib contrib-type="author"><name><surname>Lissowska</surname><given-names>Jolanta</given-names></name><xref ref-type="aff" rid="A183">185</xref></contrib><contrib contrib-type="author"><name><surname>Brinton</surname><given-names>Louise A.</given-names></name><xref ref-type="aff" rid="A182">184</xref></contrib><contrib contrib-type="author"><name><surname>Wentzensen</surname><given-names>Nicolas</given-names></name><xref ref-type="aff" rid="A182">184</xref></contrib><contrib contrib-type="author"><name><surname>Hogdall</surname><given-names>Claus</given-names></name><xref ref-type="aff" rid="A147">149</xref></contrib><contrib contrib-type="author"><name><surname>Lundvall</surname><given-names>Lene</given-names></name><xref ref-type="aff" rid="A147">149</xref></contrib><contrib contrib-type="author"><name><surname>Nedergaard</surname><given-names>Lotte</given-names></name><xref ref-type="aff" rid="A184">186</xref></contrib><contrib contrib-type="author"><name><surname>Baker</surname><given-names>Helen</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Song</surname><given-names>Honglin</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Eccles</surname><given-names>Diana</given-names></name><xref ref-type="aff" rid="A185">187</xref></contrib><contrib contrib-type="author"><name><surname>McNeish</surname><given-names>Ian</given-names></name><xref ref-type="aff" rid="A186">188</xref></contrib><contrib contrib-type="author"><name><surname>Paul</surname><given-names>James</given-names></name><xref ref-type="aff" rid="A187">189</xref></contrib><contrib contrib-type="author"><name><surname>Carty</surname><given-names>Karen</given-names></name><xref ref-type="aff" rid="A187">189</xref></contrib><contrib contrib-type="author"><name><surname>Siddiqui</surname><given-names>Nadeem</given-names></name><xref ref-type="aff" rid="A188">190</xref></contrib><contrib contrib-type="author"><name><surname>Glasspool</surname><given-names>Rosalind</given-names></name><xref ref-type="aff" rid="A187">189</xref></contrib><contrib contrib-type="author"><name><surname>Whittemore</surname><given-names>Alice S.</given-names></name><xref ref-type="aff" rid="A189">191</xref></contrib><contrib contrib-type="author"><name><surname>Rothstein</surname><given-names>Joseph H.</given-names></name><xref ref-type="aff" rid="A189">191</xref></contrib><contrib contrib-type="author"><name><surname>McGuire</surname><given-names>Valerie</given-names></name><xref ref-type="aff" rid="A189">191</xref></contrib><contrib contrib-type="author"><name><surname>Sieh</surname><given-names>Weiva</given-names></name><xref ref-type="aff" rid="A189">191</xref></contrib><contrib contrib-type="author"><name><surname>Ji</surname><given-names>Bu-Tian</given-names></name><xref ref-type="aff" rid="A182">184</xref></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Wei</given-names></name><xref ref-type="aff" rid="A190">192</xref></contrib><contrib contrib-type="author"><name><surname>Shu</surname><given-names>Xiao-Ou</given-names></name><xref ref-type="aff" rid="A190">192</xref></contrib><contrib contrib-type="author"><name><surname>Gao</surname><given-names>Yu-Tang</given-names></name><xref ref-type="aff" rid="A191">193</xref></contrib><contrib contrib-type="author"><name><surname>Rosen</surname><given-names>Barry</given-names></name><xref ref-type="aff" rid="A192">194</xref><xref ref-type="aff" rid="A193">195</xref></contrib><contrib contrib-type="author"><name><surname>Risch</surname><given-names>Harvey A.</given-names></name><xref ref-type="aff" rid="A194">196</xref></contrib><contrib contrib-type="author"><name><surname>McLaughlin</surname><given-names>John R.</given-names></name><xref ref-type="aff" rid="A195">197</xref></contrib><contrib contrib-type="author"><name><surname>Narod</surname><given-names>Steven A.</given-names></name><xref ref-type="aff" rid="A196">198</xref></contrib><contrib contrib-type="author"><name><surname>Monteiro</surname><given-names>Alvaro N.</given-names></name><xref ref-type="aff" rid="A93">95</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Ann</given-names></name><xref ref-type="aff" rid="A197">199</xref></contrib><contrib contrib-type="author"><name><surname>Lin</surname><given-names>Hui-Yi</given-names></name><xref ref-type="aff" rid="A197">199</xref></contrib><contrib contrib-type="author"><name><surname>Permuth-Wey</surname><given-names>Jenny</given-names></name><xref ref-type="aff" rid="A93">95</xref></contrib><contrib contrib-type="author"><name><surname>Sellers</surname><given-names>Thomas A.</given-names></name><xref ref-type="aff" rid="A93">95</xref></contrib><contrib contrib-type="author"><name><surname>Tsai</surname><given-names>Ya-Yu</given-names></name><xref ref-type="aff" rid="A93">95</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Zhihua</given-names></name><xref ref-type="aff" rid="A197">199</xref></contrib><contrib contrib-type="author"><name><surname>Ziogas</surname><given-names>Argyrios</given-names></name><xref ref-type="aff" rid="A198">200</xref></contrib><contrib contrib-type="author"><name><surname>Anton-Culver</surname><given-names>Hoda</given-names></name><xref ref-type="aff" rid="A198">200</xref></contrib><contrib contrib-type="author"><name><surname>Gentry-Maharaj</surname><given-names>Aleksandra</given-names></name><xref ref-type="aff" rid="A199">201</xref></contrib><contrib contrib-type="author"><name><surname>Menon</surname><given-names>Usha</given-names></name><xref ref-type="aff" rid="A199">201</xref></contrib><contrib contrib-type="author"><name><surname>Harrington</surname><given-names>Patricia</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Alice W.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Anna H.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Pearce</surname><given-names>Celeste L.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Coetzee</surname><given-names>Gerhard A.</given-names></name><xref ref-type="aff" rid="A12">12</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Pike</surname><given-names>Malcolm C.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A200">202</xref></contrib><contrib contrib-type="author"><name><surname>Dansonka-Mieszkowska</surname><given-names>Agnieszka</given-names></name><xref ref-type="aff" rid="A201">203</xref></contrib><contrib contrib-type="author"><name><surname>Timorek</surname><given-names>Agnieszka</given-names></name><xref ref-type="aff" rid="A202">204</xref></contrib><contrib contrib-type="author"><name><surname>Rzepecka</surname><given-names>Iwona K.</given-names></name><xref ref-type="aff" rid="A201">203</xref></contrib><contrib contrib-type="author"><name><surname>Kupryjanczyk</surname><given-names>Jolanta</given-names></name><xref ref-type="aff" rid="A201">203</xref></contrib><contrib contrib-type="author"><name><surname>Freedman</surname><given-names>Matt</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Noushmehr</surname><given-names>Houtan</given-names></name><xref ref-type="aff" rid="A9">9</xref><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Offit</surname><given-names>Kenneth</given-names></name><xref ref-type="aff" rid="A91">93</xref></contrib><contrib contrib-type="author"><name><surname>Couch</surname><given-names>Fergus J.</given-names></name><xref ref-type="aff" rid="A88">90</xref><xref ref-type="aff" rid="A89">91</xref></contrib><contrib contrib-type="author"><name><surname>Gayther</surname><given-names>Simon</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Pharoah</surname><given-names>Paul P.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Antoniou</surname><given-names>Antonis C.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><collab>on behalf of the Consortium of Investigators of Modifiers of <italic>BRCA1</italic> and <italic>BRCA2</italic></collab></contrib></contrib-group><aff id="A1"><label>1</label>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</aff><aff id="A2"><label>2</label>Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA</aff><aff id="A3"><label>3</label>Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK</aff><aff id="A4"><label>4</label>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia</aff><aff id="A5"><label>5</label>Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA</aff><aff id="A6"><label>6</label>Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA</aff><aff id="A7"><label>7</label>Knight Cancer Institute, Portland, OR, USA</aff><aff id="A8"><label>8</label>Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA</aff><aff id="A9"><label>9</label>Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Brazil</aff><aff id="A10"><label>10</label>Center For Cell Based Therapy, Monte Alegre, Ribeirão Preto, SP, Brazil</aff><aff id="A11"><label>11</label>Center for Integrative Systems Biology, Monte Alegre, Ribeirão Preto, SP, Brazil</aff><aff id="A12"><label>12</label>Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA</aff><aff id="A13"><label>13</label>Department of Urology, University of Southern California, Los Angeles, CA, USA</aff><aff id="A14"><label>14</label>Department of Genomics and Genome Sciences, Case Western Reserve University Medical School, Cleveland, OH, USA</aff><aff id="A15"><label>15</label>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, VIC, Australia</aff><aff id="A16"><label>16</label>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</aff><aff id="A17"><label>17</label>Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA</aff><aff id="A18"><label>18</label>Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, USA</aff><aff id="A19"><label>19</label>Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius, Lithuania</aff><aff id="A20"><label>20</label>State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania</aff><aff id="A21"><label>21</label>Department of Genetics, University of Pretoria, Pretoria, South Africa</aff><aff id="A22"><label>22</label>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA</aff><aff id="A23"><label>23</label>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</aff><aff id="A24"><label>24</label>Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</aff><aff id="A25"><label>25</label>Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</aff><aff id="A26"><label>26</label>Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain</aff><aff id="A27"><label>27</label>Genotyping Unit (CeGen), Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain</aff><aff id="A28"><label>28</label>Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</aff><aff id="A29"><label>29</label>Maricopa Medical Center, care of City of Hope Clinical Cancer Genetics Community Research Network, Duarte, CA, USA</aff><aff id="A30"><label>30</label>Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network, Duarte, CA, USA</aff><aff id="A31"><label>31</label>Cook County Health and Hospital System, care of City of Hope Clinical Cancer Genetics Community Research Network, Duarte, CA, USA</aff><aff id="A32"><label>32</label>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</aff><aff id="A33"><label>33</label>Department of Experimental Oncology, Istituto Europeo di Oncologia, Milan, Italy</aff><aff id="A34"><label>34</label>Cogentech Cancer Genetic Test Laboratory, Milan, Italy</aff><aff id="A35"><label>35</label>Division of Experimental Oncology, CRO Aviano National Cancer Institute, Aviano (PN), Italy</aff><aff id="A36"><label>36</label>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy</aff><aff id="A37"><label>37</label>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</aff><aff id="A38"><label>38</label>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</aff><aff id="A39"><label>39</label>Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy</aff><aff id="A40"><label>40</label>Department of Molecular Medicine, University La Sapienza, Rome, Italy</aff><aff id="A41"><label>41</label>Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research "Demokritos", Aghia Paraskevi Attikis, Athens, Greece</aff><aff id="A42"><label>42</label>Cancer Risk and Prevention Clinic, Dana Farber Cancer Institute, Boston, MA, USA</aff><aff id="A43"><label>44</label>Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA</aff><aff id="A44"><label>45</label>Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Germany</aff><aff id="A45"><label>46</label>Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Germany</aff><aff id="A46"><label>47</label>Center for Molecular Medicine Cologne (CMMC), University of Cologne, Germany</aff><aff id="A47"><label>49</label>Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany</aff><aff id="A48"><label>50</label>Institute for Medical Informatics, Statistics and Epidemiology University of Leipzig, Leipzig, Germany</aff><aff id="A49"><label>51</label>University Heidelberg, Heidelberg, Germany</aff><aff id="A50"><label>52</label>INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France</aff><aff id="A51"><label>53</label>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon – Centre Léon Bérard, Lyon, France</aff><aff id="A52"><label>54</label>Institut Curie, Department of Tumour Biology, Paris, France</aff><aff id="A53"><label>55</label>Institut Curie, INSERM U830, Paris, France</aff><aff id="A54"><label>56</label>Université Paris Descartes, Sorbonne Paris Cité, France</aff><aff id="A55"><label>57</label>Center for Medical Genetics, Ghent University, Ghent, Belgium</aff><aff id="A56"><label>58</label>Australia New Zealand Gynecologic Oncology Group (ANZGOG) and Familial Cancer Service, Westmead Hosptial, Sydney, Australia</aff><aff id="A57"><label>59</label>Division of Gynecologic Oncology, NorthShore University HealthSystem, Evanston, IL, USA</aff><aff id="A58"><label>60</label>Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, NY, USA</aff><aff id="A59"><label>61</label>James Cancer Center, Ohio State University, Columbus, OH, USA</aff><aff id="A60"><label>62</label>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid, Spain</aff><aff id="A61"><label>63</label>Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A62"><label>64</label>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland</aff><aff id="A63"><label>65</label>Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A64"><label>66</label>Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</aff><aff id="A65"><label>67</label>Department of Genetics, University Medical Center, Groningen University, Groningen, The Netherlands</aff><aff id="A66"><label>68</label>Latvian Biomedical Research and Study Centre, Riga, Latvia</aff><aff id="A67"><label>69</label>Department of Medical Oncology, Beth Israel Deaconess Medical Center</aff><aff id="A68"><label>70</label>Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany</aff><aff id="A69"><label>71</label>Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, USA</aff><aff id="A70"><label>72</label>Program in Cancer Genetics, McGill University, Montreal, Quebec, Canada</aff><aff id="A71"><label>73</label>N.N. Petrov Institute of Oncology, St.Petersburg, Russia</aff><aff id="A72"><label>74</label>Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, Pisa, Italy</aff><aff id="A73"><label>75</label>VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Australia</aff><aff id="A74"><label>76</label>Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands</aff><aff id="A75"><label>77</label>Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary</aff><aff id="A76"><label>78</label>Oncogenetics Group, University Hospital Vall d’Hebron, Vall d’Hebron Institute of Oncology (VHIO) and Universitat Autònoma de Barcelona; Barcelona, Spain</aff><aff id="A77"><label>79</label>Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</aff><aff id="A78"><label>80</label>Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI-Catalan Institute of Oncology, Girona, Spain</aff><aff id="A79"><label>81</label>Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</aff><aff id="A80"><label>82</label>Breast Cancer and Systems Biology Unit, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</aff><aff id="A81"><label>83</label>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</aff><aff id="A82"><label>84</label>Department of Pathology, Landspitali University Hospital and BMC, Faculty of Medicine, University of Iceland, Reykjavik, Iceland</aff><aff id="A83"><label>85</label>Gynaecologic Oncology Service, Centre Hospitalier Universitaire de Québec (CHUQ), Québec, Canada</aff><aff id="A84"><label>86</label>Centre Hospitalier Universitaire de Québec Research Center, Laval University, Quebec City, Canada</aff><aff id="A85"><label>87</label>Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS, Padua, Italy</aff><aff id="A86"><label>88</label>Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal</aff><aff id="A87"><label>89</label>Department of Genetics, Portuguese Oncology Institute, Porto, Portugal</aff><aff id="A88"><label>90</label>Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</aff><aff id="A89"><label>91</label>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</aff><aff id="A90"><label>92</label>National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA</aff><aff id="A91"><label>93</label>Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, USA</aff><aff id="A92"><label>94</label>Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</aff><aff id="A93"><label>95</label>Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA</aff><aff id="A94"><label>96</label>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA</aff><aff id="A95"><label>97</label>Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel</aff><aff id="A96"><label>98</label>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada</aff><aff id="A97"><label>99</label>Laboratory Medicine Program, University Health Network, Toronto, ON, Canada</aff><aff id="A98"><label>100</label>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada</aff><aff id="A99"><label>101</label>Department of Molecular Genetics, University of Toronto, ON, Canada</aff><aff id="A100"><label>102</label>Department of Molecular Virology, Immunology and Medical Genetics, Columbus, OH, USA</aff><aff id="A101"><label>103</label>Department of Clinical Genetics, Aarhus University Hospital, Aarhus N, Denmark</aff><aff id="A102"><label>104</label>Department of Clinical Genetics, Odense University Hospital, Odense C, Denmark</aff><aff id="A103"><label>105</label>Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark</aff><aff id="A104"><label>106</label>Institute of Oncology, Rivka Ziv Medical Center, Zefat, Israel</aff><aff id="A105"><label>107</label>Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel Aviv, Israel</aff><aff id="A106"><label>108</label>Department of Clinical Genetics, Lund University Hospital, Lund, Sweden</aff><aff id="A107"><label>109</label>Department of Oncology, Karolinska University Hospital, Stockholm, Sweden</aff><aff id="A108"><label>110</label>Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden</aff><aff id="A109"><label>111</label>Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden</aff><aff id="A110"><label>112</label>Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, USA</aff><aff id="A111"><label>113</label>Department of Medicine and Genetics, University of California, San Francisco, USA</aff><aff id="A112"><label>114</label>Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, PA, USA</aff><aff id="A113"><label>115</label>Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA</aff><aff id="A114"><label>116</label>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</aff><aff id="A115"><label>117</label>Department of Obstetrics and Gynecology, Erlangen University Hospital, University of Erlangen-Nuremberg, Erlangen, Germany</aff><aff id="A116"><label>118</label>Institute of Human Genetics, University of Erlangen-Nuremberg, Erlangen, Germany</aff><aff id="A117"><label>119</label>University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, Los Angeles, CA, USA</aff><aff id="A118"><label>120</label>Vesalius Research Center, VIB, Leuven, Belgium</aff><aff id="A119"><label>121</label>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Belgium</aff><aff id="A120"><label>122</label>Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Belgium</aff><aff id="A121"><label>123</label>Department of Community and Family Medicine, Section of Biostatistics & Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA</aff><aff id="A122"><label>124</label>Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA</aff><aff id="A123"><label>125</label>Department of Epidemiology, University of Washington, Seattle, WA, USA</aff><aff id="A124"><label>126</label>German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany</aff><aff id="A125"><label>127</label>Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</aff><aff id="A126"><label>128</label>Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA</aff><aff id="A127"><label>129</label>Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA</aff><aff id="A128"><label>130</label>Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, USA</aff><aff id="A129"><label>131</label>Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</aff><aff id="A130"><label>132</label>Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA</aff><aff id="A131"><label>133</label>Department of Gynecology, Jena University Hospital - Friedrich Schiller University, Jena, Germany</aff><aff id="A132"><label>134</label>Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</aff><aff id="A133"><label>135</label>Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</aff><aff id="A134"><label>136</label>Byelorussian Institute for Oncology and Medical Radiology Aleksandrov N.N., Minsk, Belarus</aff><aff id="A135"><label>137</label>Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A136"><label>138</label>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA</aff><aff id="A137"><label>139</label>Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</aff><aff id="A138"><label>140</label>Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, PA, USA</aff><aff id="A139"><label>141</label>Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA</aff><aff id="A140"><label>142</label>The University of Texas School of Public Health, Houston, TX, USA</aff><aff id="A141"><label>143</label>Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany</aff><aff id="A142"><label>144</label>Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany</aff><aff id="A143"><label>145</label>Institut für Humangenetik Wiesbaden, Wiesbaden, Germany</aff><aff id="A144"><label>146</label>Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Fukuoka, Japan</aff><aff id="A145"><label>147</label>Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan</aff><aff id="A146"><label>148</label>Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark</aff><aff id="A147"><label>149</label>Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</aff><aff id="A148"><label>150</label>Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark</aff><aff id="A149"><label>151</label>Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia</aff><aff id="A150"><label>152</label>Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia</aff><aff id="A151"><label>153</label>University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia</aff><aff id="A152"><label>154</label>Biostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, KS, USA</aff><aff id="A153"><label>155</label>Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA</aff><aff id="A154"><label>156</label>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia</aff><aff id="A155"><label>157</label>College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas, USA</aff><aff id="A156"><label>158</label>Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA</aff><aff id="A157"><label>159</label>Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</aff><aff id="A158"><label>160</label>Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA</aff><aff id="A159"><label>161</label>Department of Statistical Science, Duke University, Durham, North Carolina, USA</aff><aff id="A160"><label>162</label>Cancer Control and Population Sciences, Duke Cancer Institute, Durham, North Carolina, USA</aff><aff id="A161"><label>163</label>Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA</aff><aff id="A162"><label>164</label>Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Fl, USA</aff><aff id="A163"><label>165</label>Genetics Institute, University of Florida, Gainesville, FL, USA</aff><aff id="A164"><label>166</label>Harvard School of Public Health, Boston, MA, USA</aff><aff id="A165"><label>167</label>Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA</aff><aff id="A166"><label>168</label>Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA</aff><aff id="A167"><label>169</label>Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</aff><aff id="A168"><label>170</label>Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA</aff><aff id="A169"><label>171</label>Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, Epidemiology Service, New York, NY, USA</aff><aff id="A170"><label>172</label>Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway</aff><aff id="A171"><label>173</label>Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway</aff><aff id="A172"><label>174</label>Department of Gynaecology, Radboud University Medical Centre, Nijmegen, The Netherlands</aff><aff id="A173"><label>175</label>Comprehensive Cancer Center The Netherlands, Utrecht, The Netherlands</aff><aff id="A174"><label>176</label>Department for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands</aff><aff id="A175"><label>177</label>Department of Urology, Radboud University Medical Centre, Nijmegen, Netherlands</aff><aff id="A176"><label>178</label>Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada</aff><aff id="A177"><label>179</label>Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC Canada</aff><aff id="A178"><label>180</label>Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, USA</aff><aff id="A179"><label>181</label>Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA</aff><aff id="A180"><label>182</label>Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada</aff><aff id="A181"><label>183</label>International Hereditary Cancer Center, Department of Genetics and Pathology, Clinic of Opthalmology, Pomeranian Medical University, Szczecin, Poland</aff><aff id="A182"><label>184</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA</aff><aff id="A183"><label>185</label>Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</aff><aff id="A184"><label>186</label>Department of Pathology, Rigshospitalet, University of Copenhagen, Denmark</aff><aff id="A185"><label>187</label>Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK</aff><aff id="A186"><label>188</label>Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow, UK</aff><aff id="A187"><label>189</label>Cancer Research UK Clinical Trials Unit, Glasgow, The Beatson West of Scotland Cancer Centre, Glasgow, UK</aff><aff id="A188"><label>190</label>Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, UK</aff><aff id="A189"><label>191</label>Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA, USA</aff><aff id="A190"><label>192</label>Vanderbilt University School of Medicine, Nashville, TN, USA</aff><aff id="A191"><label>193</label>Shanghai Cancer Institute, Shanghai, China</aff><aff id="A192"><label>194</label>Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada</aff><aff id="A193"><label>195</label>Department of Gynecologic-Oncology, Princess Margaret Hospital, Toronto, ON, Canada</aff><aff id="A194"><label>196</label>Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA</aff><aff id="A195"><label>197</label>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada</aff><aff id="A196"><label>198</label>Women's College Research Institute, University of Toronto, Toronto, ON, Canada</aff><aff id="A197"><label>199</label>Department of Biostatistics, Moffitt Cancer Center, Tampa, FL, USA</aff><aff id="A198"><label>200</label>Department of Epidemiology, University of California Irvine, Irvine, CA, USA</aff><aff id="A199"><label>201</label>Women's Cancer, UCL EGA Institute for Women's Health, London, UK</aff><aff id="A200"><label>202</label>Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</aff><aff id="A201"><label>203</label>Department of Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</aff><aff id="A202"><label>204</label>Department of Obstetrics, Gynecology and Oncology, IInd Faculty of Medicine, Warsaw Medical University and Brodnowski Hospital, Warsaw, Poland</aff><author-notes><fn id="FN1"><label>43</label><p id="P1">A full list of members appears in the <xref ref-type="supplementary-material" rid="SD1">supplementary notes</xref>.</p></fn><fn id="FN2"><label>48</label><p id="P2">on behalf of the German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC).</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>21</day><month>12</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>12</day><month>1</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>2</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>8</month><year>2015</year></pub-date><volume>47</volume><issue>2</issue><fpage>164</fpage><lpage>171</lpage><pmc-comment>elocation-id from pubmed: 10.1038/ng.3185</pmc-comment>
<permissions><license xlink:href="http://www.nature.com/authors/editorial_policies/license.html#terms"><license-p>Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:<ext-link ext-link-type="uri" xlink:href="http://www.nature.com/authors/editorial_policies/license.html#terms">http://www.nature.com/authors/editorial_policies/license.html#terms</ext-link></license-p></license></permissions></article-meta></front><body><p id="P3">Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is consistent in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers who are at high EOC risk. After imputation to the 1000 Genomes Project data, we assessed associations of 11 million genetic variants with EOC risk from 15,397 cases unselected for family history and 30,816 controls, 15,252 <italic>BRCA1</italic> mutation carriers and 8,211 <italic>BRCA2</italic> mutation carriers (3,096 with ovarian cancer), and combined the results in a meta-analysis. This new study design yielded increased statistical power, leading to the discovery of six new EOC susceptibility loci. Variants at 1p36 (nearest gene <italic>WNT4</italic>), 4q26 (<italic>SYNPO2</italic>), 9q34.2 (<italic>ABO</italic>) and 17q11.2 (<italic>ATAD5</italic>) were associated with EOC risk, and at 1p34.3 (<italic>RSPO1</italic>) and 6p22.1 (<italic>GPX6</italic>) specifically with the serous EOC subtype, at p<5×10<sup>−8</sup>. Incorporating these variants into risk assessment tools will improve clinical risk predictions for <italic>BRCA1/2</italic> mutation carriers.</p><p id="P4">The risk of developing invasive EOC is higher than the population average for relatives of women diagnosed with the disease<sup><xref rid="R1" ref-type="bibr">1</xref>,<xref rid="R2" ref-type="bibr">2</xref></sup>, indicating the importance of genetic factors in disease susceptibility. Approximately 25% of the familial aggregation of EOC is explained by rare, high-penetrance alleles of <italic>BRCA1</italic> and <italic>BRCA2</italic><sup><xref rid="R3" ref-type="bibr">3</xref></sup>. Furthermore, population-based GWAS have identified common variants associated with invasive EOC at 11 loci<sup><xref rid="R4" ref-type="bibr">4</xref>–<xref rid="R9" ref-type="bibr">9</xref></sup> but only six have also been evaluated in <italic>BRCA1</italic> and/or <italic>BRCA2</italic> mutation carriers. All loci displayed associations in mutation carriers that were consistent with the associations observed in the general population<sup><xref rid="R10" ref-type="bibr">10</xref>–<xref rid="R12" ref-type="bibr">12</xref></sup>. In addition, the 4q32.3 locus is associated with EOC risk for <italic>BRCA1</italic> mutation carriers only<sup><xref rid="R13" ref-type="bibr">13</xref></sup>. However, the common genetic variants explain less than 3.1% of the excess familial risk of EOC so additional susceptibility loci are likely to exist.</p><p id="P5">Women diagnosed with EOC and unaffected women from the general population ascertained through the Ovarian Cancer Association Consortium (OCAC)<sup><xref rid="R14" ref-type="bibr">14</xref></sup> and <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers from the Consortium of Investigators of Modifiers of <italic>BRCA1/2</italic> (CIMBA)<sup><xref rid="R15" ref-type="bibr">15</xref></sup> were genotyped as part of the Collaborative Oncological Gene-environment Study (COGS) using the iCOGS custom array. In addition, data were available for cases and controls from three EOC GWAS. We first evaluated whether the EOC susceptibility loci at 8q21.13, 10p12.31, 17q12, 5p15.33, and 17q21.31 recently identified by OCAC<sup><xref rid="R7" ref-type="bibr">7</xref>–<xref rid="R9" ref-type="bibr">9</xref></sup> also show evidence of association in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers. Using data from >200,000 genotyped SNPs<sup><xref rid="R7" ref-type="bibr">7</xref>,<xref rid="R13" ref-type="bibr">13</xref>,<xref rid="R16" ref-type="bibr">16</xref></sup>, we performed imputation of common variants from the 1000 Genomes Project data<sup><xref rid="R17" ref-type="bibr">17</xref></sup> and evaluated the associations of these SNPs with invasive EOC risk in OCAC and in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers from CIMBA. Given the strong evidence for a significant overlap in loci predisposing to EOC in the general population and those associated with risk in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers, we carried out a meta-analysis of the EOC risk associations in order to identify novel EOC susceptibility loci.</p><p id="P6">Genotype data were available for imputation on 15,252 <italic>BRCA1</italic> mutation carriers and 8,211 <italic>BRCA2</italic> mutation carriers, of whom 2,462 and 631, respectively, were affected with EOC<sup><xref rid="R13" ref-type="bibr">13</xref>,<xref rid="R16" ref-type="bibr">16</xref></sup>. From OCAC, genotyping data were available from 15,437 women with invasive EOC (including 9,627 with serous EOC) and 30,845 controls from the general population<sup><xref rid="R7" ref-type="bibr">7</xref></sup>. Imputation was performed separately for <italic>BRCA1</italic> carriers, <italic>BRCA2</italic> carriers, OCAC-COGS samples and the three OCAC GWAS (<xref ref-type="supplementary-material" rid="SD1">Supplementary Tables 1–2; Supplementary Fig. 1; Supplementary Fig. 2</xref>). The meta-analysis was based on 11,403,952 SNPs (<xref ref-type="supplementary-material" rid="SD1">Supplementary Fig. 3</xref>).</p><p id="P7">Of five EOC susceptibility loci that have not yet been evaluated in mutation carriers, two were associated with EOC risk for both <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers at p<0.05 (10p12.31 and 17q21.31) (<xref ref-type="supplementary-material" rid="SD1">Supplementary Table 3</xref>). Overall, seven of the twelve known EOC susceptibility loci provided evidence of association in <italic>BRCA1</italic> mutation carriers and six were associated in <italic>BRCA2</italic> mutation carriers. However, with the exception of 5p15.33 (<italic>TERT</italic>), all loci had hazard ratio (HR) estimates in <italic>BRCA1</italic> and <italic>BRCA2</italic> carriers that were in the same direction as the odds ratio (OR) estimates for serous subtype EOC from OCAC (<xref ref-type="fig" rid="F1">Fig. 1</xref>). Analysing the associations jointly in <italic>BRCA1</italic> and <italic>BRCA2</italic> carriers and serous EOC in OCAC provided stronger evidence of association, with smaller p-values for eight of the susceptibility variants compared to the analysis in OCAC alone.</p><p id="P8">Using the imputed genotypes, we observed no novel associations at p<5×10<sup>−8</sup> in the analysis of associations in <italic>BRCA1</italic> or <italic>BRCA2</italic> mutation carriers separately. However, we identified seven previously unreported associations (p-values<5×10<sup>−8</sup>) in either OCAC alone, the meta-analysis of EOC associations in <italic>BRCA1, BRCA2</italic> carriers and OCAC, or in the meta-analysis in <italic>BRCA1</italic> and <italic>BRCA2</italic> carriers and serous EOC in OCAC (<xref ref-type="supplementary-material" rid="SD1">Supplementary Fig. 4; Supplementary Tables 4–5</xref>). SNPs in six of these loci remained genome-wide statistically significant after re-imputing genotypes with imputation parameters set to maximise accuracy (<xref ref-type="table" rid="T1">Table 1</xref>; <xref ref-type="fig" rid="F1">Fig. 1</xref>). SNPs at 17q11.2 (near <italic>ATAD5</italic>) were found to be associated with invasive EOC in OCAC (p<5×10<sup>−8</sup>) (<xref ref-type="table" rid="T1">Table 1</xref>). For the lead SNP, chr17:29181220:I, the estimated HR estimate for <italic>BRCA1</italic> mutation carriers was significantly different from the estimate in OCAC (p=0.005); the association for <italic>BRCA2</italic> carriers was consistent with the OCAC OR estimate (<italic>BRCA2-OCAC</italic> meta-analysis p=2.6×10<sup>−9</sup>). SNPs at four loci were associated at p<5×10<sup>−8</sup> with risk of all invasive EOC in the meta-analysis (<xref ref-type="supplementary-material" rid="SD1">Supplementary Fig. 5</xref>): 1p36, 1p34.3, 4q26, and 9q34.2. At 1p34.3, the most strongly associated SNP, rs58722170, displayed stronger associations in the meta-analysis of serous EOC for OCAC (p=2.7×10<sup>−12</sup>). In addition, SNPs at 6p22.1 were associated at genome-wide significance level in the meta-analysis of associations with serous EOC (p=3.0×10<sup>−8</sup>), but not in the meta-analysis of all invasive EOC associations (p=6.8×10<sup>−6</sup>).</p><p id="P9">The most significantly associated SNP at each of the six novel loci had high imputation accuracy (r<sup>2</sup>≥0.83). At the 1p34.3, 1p36, and 6p22.1 loci, there was at least one genome-wide significant genotyped SNP correlated with the lead SNP (pairwise r<sup>2</sup>≥0.73) (<xref ref-type="supplementary-material" rid="SD1">Supplementary Table 6; Supplementary Fig. 5; Supplementary Note</xref>). We genotyped the leading (imputed) SNPs of the three other loci in a subset of the samples using iPLEX (<xref ref-type="supplementary-material" rid="SD1">Supplementary Note</xref>). The correlations between the expected allele dosages from the imputation and the observed genotypes for the variants at 4q26 and 9q34.2, (r<sup>2</sup>=0.90 and r<sup>2</sup>=0.84, respectively) were consistent with the estimated imputation accuracy (0.93 and 0.83 for CIMBA samples). The lead SNP at 17q11.2 failed iPLEX design. However, the risk allele is highly correlated with the <italic>AA</italic> haplotype of two genotyped variants on the iCOGS array (rs9910051 and rs3764419). This haplotype is strongly associated with ovarian cancer risk in the subset of samples genotyped using iCOGS (<italic>BRCA2-OCAC</italic> meta-analysis p=8.6×10<sup>−8</sup> for haplotype, and p=1.8×10<sup>−8</sup> for chr17:29181220:I) (<xref ref-type="supplementary-material" rid="SD1">Supplementary Table 7</xref>).</p><p id="P10">None of the regions contained additional SNPs that displayed EOC associations at p<10<sup>−4</sup> in OCAC, <italic>BRCA1</italic> carriers or <italic>BRCA2</italic> carriers in multi-variable analyses adjusted for the lead SNP in each region, indicating that they each contain only one independent set of correlated highly associated variants (iCHAV). Relative to the 1000 Genomes Project data, we had genotyped or imputed data covering 91% of the genetic variation at 1p36, 84% at 1p34.3 and 83% at 4q26. The other three novel loci had coverage of less than 80% (<xref ref-type="supplementary-material" rid="SD1">Supplementary Note</xref>). There was evidence for heterogeneity at p<0.05 in the associations with histological subtype in OCAC for the lead SNPs at 1p34.4 and 6p22.1, but not for at 1p36, 4q26, 9q34.2 and 17q11.2 (<xref ref-type="table" rid="T2">Table 2</xref>).</p><p id="P11">We carried out a competing risks association analysis in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers in order to investigate whether these loci are also associated with breast cancer risk for mutation carriers (<xref ref-type="supplementary-material" rid="SD1">Supplementary Note</xref>). We used the most strongly associated genotyped SNPs for this purpose because the statistical method requires actual genotypes<sup><xref rid="R18" ref-type="bibr">18</xref></sup>. The EOC HR estimates were consistent with the estimates from the main analysis for all SNPs (<xref ref-type="supplementary-material" rid="SD1">Supplementary Table 8</xref>). None of the SNPs displayed associations with breast cancer risk at p<0.05.</p><p id="P12">At each of the six loci, we identified a set of SNPs with odds of less than 100 to 1 against being the causal variant; most are in non-coding DNA regions (<xref ref-type="supplementary-material" rid="SD1">Supplementary Table 9</xref>). None were predicted to have likely deleterious functional effects although some lie in or near chromatin biofeatures in fallopian tube and ovarian epithelial cells which may represent the functional regulatory targets of the risk SNPs (<xref ref-type="table" rid="T3">Table 3</xref>; <xref ref-type="supplementary-material" rid="SD1">Supplementary Table 10</xref>). We also evaluated the protein coding genes in each region for their role in EOC development, and as candidate susceptibility gene targets. Molecular profiling data from 496 HGSOCs performed by The Cancer Genome Atlas (TCGA) indicated frequent loss/deletion at four risk loci (1p36, 4q26, 9q34.2 and 17q11.2) (<xref ref-type="supplementary-material" rid="SD1">Supplementary Table 11</xref>). Consistent with this, <italic>WNT4</italic> and <italic>ABO</italic> were significantly down-regulated in ovarian tumours while <italic>ATAD5</italic> was up-regulated. Somatic coding sequence mutations in the six genes nearest the index SNPs were rare. We performed expression quantitative trait locus (eQTL) analysis in a series of 59 normal ovarian tissues (<xref ref-type="supplementary-material" rid="SD1">Supplementary Table 12</xref>) to evaluate the gene nearest the top ranked SNP at each locus. For the five genes expressed in normal cells, we found no statistically significant eQTL associations for any of the putative causal SNPs at each locus; neither did we find any significant tumour-eQTL associations for these genes based on data from TCGA (<xref ref-type="supplementary-material" rid="SD1">Supplementary Table 12</xref>). At the 1p36 locus, the most strongly associated variant, rs56318008, is located in the promoter region of <italic>WNT4</italic> which encodes a ligand in the WNT signal transduction pathway, critical for cell proliferation and differentiation. Using a luciferase reporter assay we found no effect of these putatively causal SNPs on <italic>WNT4</italic> transcription in iOSE4 normal ovarian cells (<xref ref-type="fig" rid="F2">Fig. 2</xref>). Some of the putative causal SNPs at 1p36 are located in <italic>CDC42</italic> and <italic>LINC00339</italic>, and several are in putative regulatory domains in ovarian tissues (<xref ref-type="supplementary-material" rid="SD1">Supplementary Table 10</xref>; <xref ref-type="fig" rid="F2">Fig. 2</xref>). <italic>CDC42</italic> is known to play a role in migration and signalling in ovarian and breast cancer<sup><xref rid="R19" ref-type="bibr">19</xref>,<xref rid="R20" ref-type="bibr">20</xref></sup>. SNPs at 1p36 are also associated with increased risk of endometriosis and <italic>WNT4, CDC42</italic> and <italic>LINC00339</italic> have all been implicated in endometriosis<sup><xref rid="R21" ref-type="bibr">21</xref></sup>, a known risk factor for endometrioid and clear cell EOC<sup><xref rid="R22" ref-type="bibr">22</xref></sup>.</p><p id="P13">The strongest associated variant at 1q34, rs58722170, is located in <italic>RSPO1</italic>, which encodes R-spondin 1, a protein involved in cell proliferation (<xref ref-type="supplementary-material" rid="SD1">Supplementary Fig. 6</xref>). RSPO1 is important in tumorigenesis and early ovarian development<sup><xref rid="R23" ref-type="bibr">23</xref>,<xref rid="R24" ref-type="bibr">24</xref></sup>, and regulates <italic>WNT4</italic> expression in the ovaries<sup><xref rid="R25" ref-type="bibr">25</xref></sup>. <italic>SYNPO2</italic> at 4q26 encodes myopodin which is involved in cell motility and growth<sup><xref rid="R26" ref-type="bibr">26</xref></sup> and has a reported tumour suppressor role<sup><xref rid="R27" ref-type="bibr">27</xref>–<xref rid="R30" ref-type="bibr">30</xref></sup>. rs635634 is located upstream of the <italic>ABO</italic> gene (<xref ref-type="supplementary-material" rid="SD1">Supplementary Fig. 7</xref>). A moderately correlated variant (rs505922, r<sup>2</sup>=0.52) determines ABO blood group and is associated with increased risk of pancreatic cancer<sup><xref rid="R31" ref-type="bibr">31</xref>,<xref rid="R32" ref-type="bibr">32</xref></sup>. Previous studies in OCAC also showed a modestly increased risk of EOC for individuals with the A blood group<sup><xref rid="R33" ref-type="bibr">33</xref></sup>. The moderate correlation between rs635634 and rs505922 and considerably weaker EOC association of rs505922 (p=1.2×10<sup>−5</sup>) suggests that the association with blood group is probably not driving the association with risk. The indel, 17:29181220:I, at 17q11.2 is located in <italic>ATAD5</italic> which acts as a tumour suppressor gene<sup><xref rid="R34" ref-type="bibr">34</xref>–<xref rid="R36" ref-type="bibr">36</xref></sup> (<xref ref-type="supplementary-material" rid="SD1">Supplementary Fig. 8</xref>). ATAD5 modulates the interaction between RAD9A and BCL2 in order to induce DNA damage related apoptosis. Finally, rs116133110, at 6p22.1, lies in <italic>GPX6</italic> which has no known role in cancer.</p><p id="P14">The six novel loci reported in this study increase the number of genome-wide significant common variant loci so far identified for EOC to 18. Taken together, these explain approximately 3.9% of the excess familial relative risk of EOC in the general population, and account for approximately 5.2% of the EOC polygenic modifying variance in <italic>BRCA1</italic> mutation carriers and 9.3% in <italic>BRCA2</italic> mutation carriers. The similarity in the magnitude of associations between <italic>BRCA1</italic> and <italic>BRCA2</italic> carriers and population-based studies suggests a general model of susceptibility whereby <italic>BRCA1</italic> and <italic>BRCA2</italic> mutations and common alleles interact multiplicatively on the relative risk scale for EOC<sup><xref rid="R37" ref-type="bibr">37</xref></sup>. This model predicts large differences in absolute EOC risk between individuals carrying many alleles and individuals carrying few risk alleles of EOC susceptibility loci for <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers<sup><xref rid="R13" ref-type="bibr">13</xref>,<xref rid="R16" ref-type="bibr">16</xref></sup>. Incorporating EOC susceptibility variants into risk assessment tools will improve risk prediction and may be particularly useful for <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers.</p><sec sec-type="methods" id="S1"><title>METHODS</title><sec id="S2"><title>Study populations</title><p id="P15">We obtained data on <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers through CIMBA. Eligibility in CIMBA is restricted to females 18 years or older with pathogenic mutations in <italic>BRCA1</italic> or <italic>BRCA2</italic>. The majority of the participants were sampled through cancer genetics clinics<sup><xref rid="R15" ref-type="bibr">15</xref></sup>, including some related participants. Fifty-four studies from 27 countries contributed data. After quality control, data were available on 15,252 <italic>BRCA1</italic> mutation carriers and 8,211 <italic>BRCA2</italic> mutation carriers, of whom 2,462 and 631, respectively, were affected with EOC (<xref ref-type="supplementary-material" rid="SD1">Supplementary Table 1</xref>).</p><p id="P16">Data were available for the stage 1 of three population-based EOC GWAS. These included 2,165 cases and 2,564 controls from a GWAS from North America (“US GWAS”)<sup><xref rid="R39" ref-type="bibr">39</xref></sup>, 1,762 cases and 6,118 controls from a UK-based GWAS (“UK GWAS”)<sup><xref rid="R6" ref-type="bibr">6</xref></sup>, and 441 cases and 441 controls from the Mayo GWAS. Furthermore, 11,069 cases and 21,722 controls were genotyped using the iCOGS array (“OCAC-iCOGS” stage data). Overall, 43 studies from 11 countries provided data on 15,347 women diagnosed with invasive epithelial EOC, 9,627 of whom were diagnosed with serous EOC, and 30,845 controls from the general population.</p><p id="P17">All subjects included in this analysis were of European descent and provided written informed consent as well as data and blood samples under ethically approved protocols. Further details of the OCAC and CIMBA study populations as well as the genotyping, quality control and statistical analyses have been described elsewhere<sup><xref rid="R7" ref-type="bibr">7</xref>,<xref rid="R13" ref-type="bibr">13</xref>,<xref rid="R16" ref-type="bibr">16</xref></sup>.</p></sec><sec id="S3"><title>Genotype data</title><p id="P18">Genotyping and imputation details for each study are shown in <xref ref-type="supplementary-material" rid="SD1">Supplementary Table 1</xref>.</p></sec><sec id="S4"><title>Confirmatory genotyping of imputed SNPs</title><p id="P19">To evaluate the accuracy of the imputation of the SNPs we found to be associated with EOC risk, we genotyped rs17329882 (4q26) and rs635634 (9q34.2) in a subset of 3,541 subjects from CIMBA using Sequenon’s iPLEX technology. The lead SNP at 17q11.2, chr17:29181220:I failed iPLEX design. We performed quality control of the iPLEX data according to the CIMBA guidelines. After quality control, we used the imputation results to generate the expected allele dosage for each genotyped sample and computed the Pearson product-moment correlation coefficient between the expected allele dosage and the observed genotype. The squared correlation coefficient was compared to the imputation accuracy as estimated from the imputation.</p></sec><sec id="S5"><title>Quality control of GWAS and iCOGS genotyping data</title><p id="P20">We carried out quality control separately for <italic>BRCA1</italic> carriers, <italic>BRCA2</italic> carriers, the three OCAC GWAS, and OCAC-iCOGS samples, but quality criteria were mostly consistent across studies. We excluded samples if they were not of European ancestry, if they had a genotyping call rate < 95%, low or high heterozygosity, if they were not female or had ambiguous sex, or were duplicates (cryptic or intended). In OCAC studies, one individual was excluded from each pair of samples found to be first-degree relatives and duplicate samples between the iCOGS stage and any of the GWAS were excluded from the iCOGS data. SNPs were excluded if they were monomorphic, had call rate<95%, showed evidence of deviation from Hardy-Weinberg equilibrium or had low concordance between duplicate pairs. For the Mayo GWAS and the UK GWAS, we also excluded rare SNPs (MAF<1% or allele count <5, respectively). We visually inspected genotype cluster plots for all SNPs with P<10<sup>−5</sup> from each of the newly identified loci. We used the R GenABEL library version 1.6.7 for quality control<sup><xref rid="R40" ref-type="bibr">40</xref></sup>.</p><p id="P21">Genotype data were available for analysis from iCOGS for 199,526 SNPs in OCAC-iCOGS, 200,720 SNPs in <italic>BRCA1</italic> mutation carriers, and 200,908 SNPs in <italic>BRCA2</italic> mutation carriers. After QC, for the GWAS, data were available on 492,956 SNPs for the US GWAS, 543,529 SNPs for the UK GWAS and 1,587,051 SNPs for the Mayo GWAS (<xref ref-type="supplementary-material" rid="SD1">Supplementary Table 2</xref>).</p></sec><sec id="S6"><title>Imputation</title><p id="P22">We performed imputation separately for <italic>BRCA1</italic> carriers, <italic>BRCA2</italic> carriers, OCAC-iCOGS samples and each of the OCAC GWAS. We imputed variants from the 1000 Genomes Project data using the v3 April 2012 release<sup><xref rid="R17" ref-type="bibr">17</xref></sup> as the reference panel. For OCAC-iCOGS, the UK GWAS and the Mayo GWAS, imputation was based on the 1000 Genomes Project data with singleton sites removed. To improve computation efficiency we initially used a two-step procedure, which involved pre-phasing in the first step and imputation of the phased data in the second. We carried out pre-phasing using the SHAPEIT software<sup><xref rid="R41" ref-type="bibr">41</xref></sup>. We used the IMPUTE version 2 software for the subsequent imputation<sup><xref rid="R42" ref-type="bibr">42</xref></sup> for all studies with the exception of the US GWAS for which the MACH algorithm implemented in the minimac software version 2012.8.15, mach version 1.0.18 was used. To perform the imputation we divided the data into segments of approximately 5Mb each. We excluded SNPs from the association analysis if their imputation accuracy was r<sup>2</sup><0.3 or their minor allele frequency (MAF) was <0.005 in <italic>BRCA1</italic> or <italic>BRCA2</italic> carriers or if their accuracy was r<sup>2</sup><0.25 in OCAC-iCOGS, the UK GWAS, UK GWAS or Mayo GWAS.</p><p id="P23">We performed more accurate imputation for the regions around the novel EOC loci from the joint analysis of the data from <italic>BRCA1</italic> and <italic>BRCA2</italic> carriers and the general population (any SNP with P<5×10<sup>−8</sup>). The boundaries of these regions were set +/− 500kb from any significantly associated SNP in the region. As in the first run, the 1000 Genomes Project data v3 were used as the reference panel and the software IMPUTE2 was applied. However, for the second round of imputation, we imputed genotypes without pre-phasing in order to improve accuracy. To further increase the imputation accuracy we changed some of the default parameters in the imputation procedure. These included an increase of the MCMC iterations to 90 (out of which the first 15 were used as burn-in), an increase of the buffer region to 500kb and an increase of the number of haplotypes used as templates when phasing observed genotypes to 100. These changes were applied consistently for all data sets.</p></sec><sec id="S7"><title>Statistical analyses</title><sec id="S8"><title>Association analyses in the unselected ovarian cancer cases and controls from OCAC</title><p id="P24">We evaluated the association between genotype and disease using logistic regression by estimating the associations with each additional copy of the minor allele (log-additive models). The analysis was adjusted for study and for population substructure by including the eigenvectors of the first five ancestry specific principal components as covariates in the model. We used the same approach to evaluate the SNP associations with serous ovarian cancer after excluding all cases with any other or with unknown tumour subtype. For imputed SNPs we used expected dosages in the logistic regression model to estimate SNP effect sizes and p-values. We carried out analyses separately for OCAC-iCOGS and the three GWAS and pooled thereafter using a fixed effects meta-analysis. We carried out the analysis of re-imputed genotypes of putative novel susceptibility loci jointly for the OCAC-iCOGS and GWAS samples. All results are based on the combined data from iCOGS and the three GWAS. We used custom written software for the analysis.</p></sec><sec id="S9"><title>Associations in BRCA1 and BRCA2 mutation carriers from CIMBA</title><p id="P25">We carried out the ovarian cancer association analyses separately for <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers. The primary analysis was carried out within a survival analysis framework with time to ovarian cancer diagnosis as the endpoint. Mutation carriers were followed until the age of ovarian cancer diagnosis, or risk-reducing salpingo-oophorectomy (RRSO) or age at last observation. Breast cancer diagnosis was not considered as a censoring event. In order to account for the non-random sampling of <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers with respect to their disease status we conducted the analyses by modelling the retrospective likelihood of the observed genotypes conditional on the disease phenotype<sup><xref rid="R18" ref-type="bibr">18</xref></sup>. We assessed the associations between genotype and risk of ovarian cancer using the 1 degree of freedom score test statistic based on the retrospective likelihood<sup><xref rid="R18" ref-type="bibr">18</xref>,<xref rid="R43" ref-type="bibr">43</xref></sup>. To account for the non-independence among related individuals in the sample, we used an adjusted version of the score test statistic, which uses a kinship adjusted variance of the score<sup><xref rid="R44" ref-type="bibr">44</xref></sup>. We evaluated associations between imputed genotypes and ovarian cancer risk using a version of the score test as described above but with the posterior genotype probabilities replacing the genotypes. All analyses were stratified by the country of origin of the samples.</p><p id="P26">We carried out the retrospective likelihood analyses in CIMBA using custom written functions in Fortran and Python. The score test statistic was implemented in R version 3.0.1<sup><xref rid="R45" ref-type="bibr">45</xref></sup>.</p><p id="P27">We evaluated whether there is evidence for multiple independent association signals in the region around each newly identified locus by evaluating the associations of genetic variants in the region while adjusting for the SNP with the smallest meta-analysis p-value in the respective region. This was done separately for <italic>BRCA1</italic> carriers, <italic>BRCA2</italic> carriers and OCAC.</p><p id="P28">For one of the novel associations, it was not possible to confirm the imputation accuracy of the lead SNP chr17:29181220:I at 17q11.2 through genotyping. Therefore, we inferred two-allele haplotypes for rs9910051 and rs3764419, highly correlated with the lead SNP (r<sup>2</sup>=0.95), using an in-house program. These variants were genotyped on the iCOGS array and therefore this analysis was restricted to 14,733 ovarian cancer cases and 9,165 controls from OCAC-COGS, and 8,185 <italic>BRCA2</italic> mutation carriers that had available genotypes for both variants based on iCOGS. The association between the AA haplotype and risk was tested using logistic regression in OCAC and using Cox regression in <italic>BRCA2</italic> mutation carriers.</p></sec><sec id="S10"><title>Meta-analysis</title><p id="P29">We conducted a meta-analysis of the EOC associations in <italic>BRCA1, BRCA2</italic> carriers and the general population for genotyped and imputed SNPs using an inverse variance approach assuming fixed effects. We combined the logarithm of the per-allele hazard ratio estimate for the association with EOC risk in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers and the logarithm of the per-allele odds ratio estimate for the association with disease status in OCAC. For the associations in <italic>BRCA1</italic> and <italic>BRCA2</italic> carriers, we used the kinship adjusted variance estimator<sup><xref rid="R44" ref-type="bibr">44</xref></sup> which allows for inclusion of related individuals in the analysis. We only used SNPs with results in OCAC and in at least one of the <italic>BRCA1</italic> or the <italic>BRCA2</italic> analyses. We carried out two separate meta-analyses, one for the associations with EOC in <italic>BRCA1</italic> carriers, <italic>BRCA2</italic> carriers and EOC in OCAC, irrespective of tumour histological subtype, and a second using only the associations with serous EOC in OCAC. The number of <italic>BRCA1</italic> and <italic>BRCA2</italic> samples with tumour histology information was too small to allow for subgroup analyses. However, previous studies have demonstrated that the majority of EOCs in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers are high-grade serous<sup><xref rid="R49" ref-type="bibr">49</xref>–<xref rid="R53" ref-type="bibr">53</xref></sup>. Meta-analyses were carried out using the software “metal”, 2011-03-25 release<sup><xref rid="R54" ref-type="bibr">54</xref></sup>.</p></sec><sec id="S11"><title>Candidate causal SNPs in each susceptibility region</title><p id="P30">In order to identify a set of potentially causal variants we excluded SNPs with a likelihood of being causal of less than 1:100, by comparing the likelihood of each SNP from the association analysis with the one of the most strongly associated SNP<sup><xref rid="R46" ref-type="bibr">46</xref></sup>. The remaining variants were then analysed using pupasuite 3.1 to identify potentially functional variants (<xref ref-type="supplementary-material" rid="SD1">Supplementary Table 9</xref>).</p></sec></sec><sec id="S12"><title>Functional analysis</title><sec id="S13"><title>Expression quantitative trait locus (eQTL) analysis in normal OSE and FTSE cells</title><p id="P31">Early-passage primary normal ovarian surface epithelial cells (OSECs) and fallopian tube epithelial cells were harvested from disease-free ovaries and fallopian tubes. Normal ovarian epithelial cells were collected by brushing the surface of the ovary with a sterile cytobrush, and were cultured in NOSE-CM<sup><xref rid="R55" ref-type="bibr">55</xref></sup>. Fallopian tube epithelial cells were harvested by Pronase digestion as previously described<sup><xref rid="R56" ref-type="bibr">56</xref></sup>, plated onto collagen-coated plastics (Sigma) and cultured in DMEM/F12 (Sigma-Aldrich) supplemented with 2% Ultroser G (BioSepra) and 1× penicillin/streptomycin (Lonza). By the time of RNA harvesting, fallopian tube cultures tested consisted of PAX8 positive fallopian tube secretory epithelial cells (FTSECs), consistent with previous observations that ciliated epithelial cells from the fallopian tube do not proliferate <italic>in vitro</italic>.</p><p id="P32">For gene expression analysis, RNA was harvested from 59 early passage samples: 54 OSECs and 5 FTSECs from cell cultures harvested at ~80% confluency using the QIAgen miRNAeasy kit with on-column DNase 1 digestion. 500ng RNA was reverse transcribed using the Superscript III kit (Life Technologies). We preamplified 10ng cDNA using the TaqMan<sup>®</sup> Preamp Mastermix; the resulting product was diluted 1:60 and used to quantify gene expression using the following TaqMan<sup>®</sup> gene expression probes: WNT4, Hs01573504_m1; RSPO1, Hs00543475_m1; SYNPO2, Hs00326493_m1; ATAD5, Hs00227495_m1 and GPX6, Hs00699698_m1. Four control genes were also included: ACTB, Hs00357333_g1; GAPDH, Hs02758991_g1; HMBS, Hs00609293_g1 and HPRT1 Hs02800695_m1 (all Life Technologies). Assays were run on an ABI 7900HT Fast Real-Time PCR system (Life Technologies).</p><sec id="S14"><title>Data Analysis</title><p id="P33">Expression levels for each gene were normalized to the average of all four control genes. Relative expression levels were calculated using the δδCt method. Genotyping was performed on the iCOGs chips, as described above. Where genotyping data were not available for the most risk-associated SNP, the next most significant SNP was used: rs3820282 at 1p36, rs12023270 at 1p34.3, rs752097 at 4q26, rs445870 at 6p22.1, rs505922 at 9q34.2 and rs3764419 at 17q11.2. Correlations between genotype and gene expression were calculated in ‘R’. Genotype specific gene expression in the normal tissue cell lines (eQTL analysis) was compared using the Jonckheere-Terpstra test. IData were normalized to the four control genes and we tested for eQTL associations, grouping OSECs and FTSECs together. Secondly, OSECs were analysed alone. eQTL analyses were performed using 3 genotype groups, or two groups (with the rare homozygote samples grouped together with the heterozygote samples).</p></sec></sec><sec id="S15"><title>eQTL analysis in primary ovarian tumours</title><p id="P34">eQTL analysis in primary tumours was based on the publicly available data available from The Cancer Genome Atlas (TCGA) project, which includes 489 primary high grade serous ovarian cancers. The methods have been described elsewhere<sup><xref rid="R57" ref-type="bibr">57</xref></sup>. Briefly, we determined the ancestry for each case based on the germ line genotype data using EIGENSTRAT software with 415 HapMap genotype profiles as a control set. Only populations of Northern and Western European ancestries were included. We first performed a <italic>cis</italic>-eQTL analyses using a method we described previously, in which the association between 906,600 germline genotypes and the expression levels of mRNA or miRNA (located within 500Kb on either side of the variant) were evaluated using linear regression model with the effects of somatic copy number and CpG methylation being deducted (For miRNA expression, the effect of CpG methylation is not adjusted for since the data are not available). To adjust for multiple tests, we adjusted the test P values using Benjamini-Hochberg method. A significant association was defined by a false discovery rate (FDR) of less than 0.1.</p><p id="P35">Having established a genome-wide <italic>cis</italic>-eQTL associaitions in this series of tumours, we then evaluated <italic>cis</italic>-eQTL associations for the top risk associations between each of the six new loci and the gene in closest proximity to the risk SNP. For each risk locus, we retrieved the genotype of all SNPs in ovarian cancer cases based on the Affymetrix 6.0 array. Using these genotypes and the impute2 March 2012 1000 Genomes Phase I integrated variant cosmopolitan reference panel of 1,092 individuals (Haplotypes were phased via SHAPEIT), we imputed the genotypes of SNPs in the 1000 Genomes Project in the target regions for TCGA samples<sup><xref rid="R58" ref-type="bibr">58</xref></sup>. For each risk locus where data for the most risk-associated variant were not available, we retrieved the imputed variants tightly correlated with the most risk-associated variant. We then tested for association between imputed SNPs and gene expression using the linear regression algorithm described above, where each imputed SNP was coded as an expected allele count. Again, significant associations are defined by a false discovery rate (FDR) of less than 0.1.</p></sec><sec id="S16"><title>Regulatory profiling of normal ovarian cancer precursor tissues</title><p id="P36">We performed genome-wide formaldehyde assisted regulatory element (FAIRE) and ChIP seq with histone 3 lysine 27 acetylation (H3K27ac) and histone 3 lysine 4 monomethylation (H3K4me) for two normal OSECs, two normal FTSECs and two HGSOC cell lines (UWB1.289 and CAOV3) [Shen et al. in preparation]. These datasets annotate epigenetic signatures of open chromatin, and collectively indicate transcriptional enhancer regions. We analysed the FAIRE-seq and ChIP-seq datasets and publically available genomic data on promoter and UTR domains, intron/exon boundaries, and positions of non-coding RNA transcripts to identify SNPs from the 100:1 likely causal set that align with biofeatures that may provide evidence of SNP functionality.</p></sec><sec id="S17"><title>Candidate Gene Analysis Using Genome Wide Profiling of Primary Ovarian Cancers</title><sec id="S18"><title>Data Sets</title><p id="P37">The Cancer Genome Atlas (TCGA) Project and COSMIC Datasets</p><p id="P38">TCGA has performed extensive genomic analysis of tumours from a large number of tissue types including almost 500 high-grade serous ovarian tumours. These data include somatic mutations, DNA copy number, mRNA and miRNA expression and DNA methylation. COSMIC is the catalogue of somatic mutations in cancer that collates information on mutations in tumours from the published literature<sup><xref rid="R59" ref-type="bibr">59</xref></sup>. They have also identified The Cancer Gene Census, which is a list of genes known to be involved in cancer. Data are available on a large number of tissue types, including 2,809 epithelial ovarian tumours.</p></sec><sec id="S19"><title>Somatic coding sequence mutations</title><p id="P39">We analysed all genes for coding somatic sequence mutations generated from either whole exome or whole genome sequencing. In TCGA, whole exome sequencing data were available for 316 high-grade serous EOC cases. In addition, we determined whether mutations had been reported in COSMIC<sup><xref rid="R59" ref-type="bibr">59</xref></sup> and whether the gene was a known cancer gene in the Sanger Cancer Gene Census.</p></sec><sec id="S20"><title>mRNA expression in tumour and normal tissue</title><p id="P40">Normalized and gene expression values (Level 3) gene expression profiling data were obtain from the TCGA data portal for three different platforms (Agilent, Affymetrix HuEx and Affymetrix U133A). We analysed only the 489 primary serous ovarian tumour samples included in the final clustering analysis<sup><xref rid="R58" ref-type="bibr">58</xref></sup> and eight normal fallopian tube samples. The boxplot function in R was used to compare ovarian tumour samples to the fallopian tube for 91 coding genes with expression data on any platform within a 1MB region around the most significant SNP at the six loci. A difference in relative expression between EOC and normal tissue was carried out using the Wilcoxon rank-sum test.</p></sec><sec id="S21"><title>DNA copy number analysis</title><p id="P41">Serous EOC samples for 481 tumours with log2 copy number data were analysed using the cBio portal for analysis of TCGA data<sup><xref rid="R60" ref-type="bibr">60</xref>,<xref rid="R61" ref-type="bibr">61</xref></sup>. For each gene in a region the classes of copy number; homozygous deletion, heterozygous loss, diploid, gain, and amplification were queried individually using the advanced onco query language (OQL) option. The frequency of gain and amplification were combined as “gain”, and homozygous deletion and heterozygous loss were combined as “loss”.</p></sec><sec id="S22"><title>Analysis of copy number vs mRNA expression</title><p id="P42">Serous EOC samples for 316 complete tumours (those with CNA, mRNA and sequencing data) were analysed. Graphs were generated using the cBio portal for analysis of TCGA data and the setting were mRNA expression data Z-score (all genes) with the Z-score threshold of 2 (default setting) and putative copy number alterations (GISTIC). The Z-score is the number of standard deviations away from the mean of expression in the reference population. GISTIC is an algorithm that attempts to identify significantly altered regions of amplification or deletion across sets of patients.</p></sec></sec><sec id="S23"><title>Luciferase Reporter Assay</title><p id="P43">The putative causal SNPs at the 1p36 locus lie in the <italic>WNT4</italic> promoter and so we tested their effect on transcription in a luciferase reporter assay (<xref ref-type="fig" rid="F2">Fig. 2D</xref>). Wild-type and risk haplotype (comprising five correlated variants) sequences corresponding to the region bound by hg19 co-ordinates chr1:22469416-22470869 were generated by Custom Gene Synthesis (GenScript Corporation), and then sub-cloned into pGL3-basic (Promega). Equimolar amounts of luciferase constructs (800 ng) and pRL-TK Renilla (50 ng) were co-transfected into ~8 × 10<sup>4</sup> iOSE4<sup><xref rid="R62" ref-type="bibr">62</xref></sup> normal ovarian cells in triplicate wells of 24 well plates using LipoFectamine 2000 (Life Technologies). Independent transfections were repeated three times. The Dual-Glo Luciferase Assay kit (Promega) was used to assay luciferase activity 24 hours post transfection using a BioTek Synergy H4 plate reader. The iOSE-4 cell line (derived by K. Lawrenson) was maintained under standard conditions and routinely tested for <italic>Mycoplasma</italic> and short tandem repeat profiled.</p></sec></sec></sec><sec sec-type="supplementary-material" id="SM"><title>Supplementary Material</title><supplementary-material content-type="local-data" id="SD1"><label>1</label><media xlink:href="NIHMS647338-supplement-1.pdf" orientation="portrait" xlink:type="simple" id="d37e4377" position="anchor"></media></supplementary-material><supplementary-material content-type="local-data" id="SD2"><label>2</label><media xlink:href="NIHMS647338-supplement-2.docx" orientation="portrait" xlink:type="simple" id="d37e4381" position="anchor"></media></supplementary-material></sec></body><back><ack id="S24"><title>Acknowledgments</title><p id="P44">We thank all the individuals who took part in this study, and all the researchers, clinicians and technical and administrative staff who made possible the many studies contributing to this work (a full list is provided in the <xref ref-type="supplementary-material" rid="SD1">Supplementary Note</xref>), including Xiao Qing Chen for iPLEX genotyping. The COGS project is funded through a European Commission's Seventh Framework Programme grant (agreement number 223175 - HEALTH-F2-2009-223175). The CIMBA data management and data analysis were supported by Cancer Research–UK grants C12292/A11174 and C1287/A10118. The Ovarian Cancer Association Consortium is supported by a grant from the Ovarian Cancer Research Fund thanks to donations by the family and friends of Kathryn Sladek Smith (PPD/RPCI.07). The scientific development and funding for this project were in part supported by the US National Cancer Institute GAME-ON Post-GWAS Initiative (U19-CA148112). This study made use of data generated by the Wellcome Trust Case Control consortium. Funding for the project was provided by the Wellcome Trust under award 076113. The results published here are in part based upon data generated by The Cancer Genome Atlas Pilot Project established by the National Cancer Institute and National Human Genome Research Institute (dbGap accession number phs000178.v8.p7). The cBio portal is developed and maintained by the Computational Biology Center at Memorial Sloan-Kettering Cancer Center. SH is supported by an NHMRC Program Grant to GCT. Details of the funding of individual investigators and studies are provided in the <xref ref-type="supplementary-material" rid="SD1">Supplementary Note</xref>. This study made use of data generated by the Wellcome Trust Case Control consortium, funding for which was provided by the Wellcome Trust under award 076113. The results published here are, in part, based upon data generated by The Cancer Genome Atlas Pilot Project established by the National Cancer Institute and National Human Genome Research Institute (dbGap accession number phs000178.v8.p7). A full list of the investigators who contributed to the generation of the data is available on the website (see URL). The cBio portal was developed and is maintained by the Computational Biology Center at Memorial Sloan-Kettering Cancer Center.</p></ack><fn-group><fn id="FN3" fn-type="con"><p id="P45">Author Contributions</p><p id="P46">Writing group: K.B.K., A.C.A., G.C-T., S.J.R, J.Beesley, P.P.P., S.G. Performed statistical analyses for CIMBA: K.B.K. Performed statistical analyses for OCAC: J.T. Performed the meta-analyses: K.B.K. CIMBA database management: L.McG. and D.B. Supervised CIMBA statistical analyses and CIMBA data management: A.C.A. Supervised OCAC statistical analyses: P.P.P. Initiated and coordinated CIMBA: G.C-T. Coordinated OCAC: A.Berchuck and P.P.P. Conceived and coordinated the synthesis of the iCOGS array: D.F.E. Co-ordinated iCOGS genotyping : J.S., K.Offit, F.J.C. iCOGS genotyping, calling and quality control: J.M.Cunningham, J.D., A.Lee, P.S., D.F.E., G.C-T., Provided DNA samples and/or phenotypic data: S.J.R., J.T., A.Lee, H.C.S., K.L., S.Healey, J.M.L., T.J.S., Y.G.L., T.P., Y.B., Q.L., S.C., D.H., A.Miron, M.Southey, M.B.T., D.E.G., S.S.B., R.J., C.M.D., E.J.vanR., S.L.N., Y.C.D., T.V.O.H, L.J., A-M.G., B.E., J.D., J.Benitez, A.O., M.J.G., I.Komenka, J.N.W., P.G., P.P., L.Bernard, A.V., B.B., B.P., S.Manoukian, P.R., L.P., L.O., F.F., I.Konstantopolous, J.Garber, D.F., J.Perkins, R.P., S.E., EMBRACE, A.K.G., R.K.S., A.Meindl, C.E., C.S., O.M.S., GEMO, F.D., S.Mazoyer, D.S-L., K.Claes, K.D.L., J.Kirk, G.C.R., M.Piedmonte, D.M.O'M., M.de la H., T.C., K.A., H.Nevalinna, J.M.Collee, M.A.Rookus, J.C.O., F.B.L.H., HEBON, E.O., O.D., I.B., J.Brunet, C.L., M.A.P., A.Jakubowska, J.Gronwald, J.Lubinksi, G.S., R.B.B., M.Plante, J.S., P.S., M.M., S.Tognazzo, M.R.T., kConFab, V.S.P., X.Wang, N.L., C.I.S., N.K., J.V., C.A.A., G.P., A.Berger, C.F.S., M-K.T., C.M.P., M.H.G., P.L.M., G.R., A.M.M., S.Tchatchou, I.L.A., G.G., A.E.T., U.B.J., T.A.K., M.T., A.Bojesen, J.Z., E.F., Y.L., M.Soller, A.Liljegren, B.A., Z.E., M.S-A., O.I.O., R.L.N., T.R.R., K.L.N., S.M.D., K.H.L., B.Y.K., C.W., J.Lester, ACS, AOCS, P.W., A.H., A.B.E., M.W.B., P.A.F., D.Lambrechts, E.V.N., I.V., S.Lambrechts, E.D., J.A.D., K.G.W., M.A.Rossing, A.R., J.C-C., S.W-G., U.E., K.B.M., K.Odunsi, L.S., S.Lele, L.R.W., M.T.G., P.J.T., Y.B.S., I.B.R., M.D., P.Hillemans, T.D., N.A., N.B., A.Leminen, L.M.P., R.B., F.M., J.L.K., R.P.E., R.B.N., A.du B., F.H., I.S., P.Harter, K.M., S.Hosono, S.O., A.Jensen, S.K.K., E.H., H.N.H., M.A.N.A., S-H.T., Y-L.W., B.L.F., E.L.G., J.M.Cunningham, R.A.V., F.B., G.G.G., D.Liang, M.A.T.H., X.Wu, D.A.L., M.B., A. Berchuck, E.S.I., J.M.S., P.C., R.P.W., D.W.C., K.L.T., E.M.P., S.S.T., E.V.B., I.O., S.H.O., C.K., H.B.S., I.L.T., L.Bjorge, A.M.van A., K.K.H.A., L.A.K., L.F.A.G.M., M.K., A.B-W., L.E.K., L.S.C., N.D.L., C.C., H.Y., J.Lissowska, L.A.B., N.W., C.H., L.L., L.N., H.B., H.S., D.E., I.G.C., I.McN., J.Paul, K.Carty, N.S., R.G., A.S.W., J.H.R., V.McG., W.S., B-T.J., W.Z., X-O.S., Y-T.G., B.R., H.A.R., J.R.McL., S.A.N., A.N.M., A.C., H-Y.L., J.P-W., T.A.S., Y-Y.T., Z.C., A.Z., H.A-C., A.G-M., U.M., P.Harrington, A.W.L., A.H.W., C.L.P., G.C., M.C.P., A.D-M., A.T., I.K.R., J.Kupryjanczyk, M.F., H.Noushmehr, D.F.E., K.Offit, F.J.C., S.G., P.P.P., A.C.A., G.C-T. All authors read and approved the final manuscript.</p></fn><fn id="FN4"><p id="P47"><underline>Websites</underline></p><p id="P48">Nature Publishing Group. <italic>Nature Genetics - iCOGS</italic>, <ext-link ext-link-type="uri" xlink:href="http://www.nature.com/icogs/">http://www.nature.com/icogs/</ext-link></p><p id="P49">The Cancer Genome Atlas Project - <ext-link ext-link-type="uri" xlink:href="http://cancergenome.nih.gov/">http://cancergenome.nih.gov/</ext-link></p><p id="P50">The cBio Cancer Genomics Portal - <ext-link ext-link-type="uri" xlink:href="http://www.cbioportal.org/">http://www.cbioportal.org/</ext-link></p><p id="P51">Pupasuite 3.1 -<ext-link ext-link-type="uri" xlink:href="http://pupasuite.bioinfo.cipf.es">http://pupasuite.bioinfo.cipf.es</ext-link></p><p id="P52">CIMBA QC guidelines-<ext-link ext-link-type="uri" xlink:href="http://ccge.medschl.cam.ac.uk/consortia/cimba/members/data%20management/CIMBA%20and%20BCAC%20Quality%20Control%20November%202008%20v2.doc">http://ccge.medschl.cam.ac.uk/consortia/cimba/members/data%20management/CIMBA%20and%20BCAC%20Quality%20Control%20November%202008%20v2.doc</ext-link></p></fn></fn-group><ref-list><title>REFERENCES</title><ref id="R1"><label>1</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Auranen</surname><given-names>A</given-names></name><etal></etal></person-group><article-title>Cancer incidence in the first-degree relatives of ovarian cancer patients</article-title><source>Br J Cancer</source><year>1996</year><volume>74</volume><fpage>280</fpage><lpage>284</lpage><pub-id pub-id-type="pmid">8688336</pub-id></element-citation></ref><ref id="R2"><label>2</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Stratton</surname><given-names>JF</given-names></name><name><surname>Pharoah</surname><given-names>P</given-names></name><name><surname>Smith</surname><given-names>SK</given-names></name><name><surname>Easton</surname><given-names>D</given-names></name><name><surname>Ponder</surname><given-names>BA</given-names></name></person-group><article-title>A systematic review and meta-analysis of family history and risk of ovarian cancer</article-title><source>Br J Obstet Gynaecol</source><year>1998</year><volume>105</volume><fpage>493</fpage><lpage>499</lpage><pub-id pub-id-type="pmid">9637117</pub-id></element-citation></ref><ref id="R3"><label>3</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jervis</surname><given-names>S</given-names></name><etal></etal></person-group><article-title>Ovarian cancer familial relative risks by tumour subtypes and by known ovarian cancer genetic susceptibility variants</article-title><source>J Med Genet</source><year>2013</year></element-citation></ref><ref id="R4"><label>4</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bolton</surname><given-names>KL</given-names></name><etal></etal></person-group><article-title>Common variants at 19p13 are associated with susceptibility to ovarian cancer</article-title><source>Nat Genet</source><year>2010</year><volume>42</volume><fpage>880</fpage><lpage>884</lpage><pub-id pub-id-type="pmid">20852633</pub-id></element-citation></ref><ref id="R5"><label>5</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Goode</surname><given-names>EL</given-names></name><etal></etal></person-group><article-title>A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24</article-title><source>Nat Genet</source><year>2010</year><volume>42</volume><fpage>874</fpage><lpage>879</lpage><pub-id pub-id-type="pmid">20852632</pub-id></element-citation></ref><ref id="R6"><label>6</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Song</surname><given-names>H</given-names></name><etal></etal></person-group><article-title>A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2</article-title><source>Nat Genet</source><year>2009</year><volume>41</volume><fpage>996</fpage><lpage>1000</lpage><pub-id pub-id-type="pmid">19648919</pub-id></element-citation></ref><ref id="R7"><label>7</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pharoah</surname><given-names>PD</given-names></name><etal></etal></person-group><article-title>GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer</article-title><source>Nat Genet</source><year>2013</year><volume>45</volume><fpage>362</fpage><lpage>370</lpage><fpage>370e361</fpage><lpage>370e362</lpage><pub-id pub-id-type="pmid">23535730</pub-id></element-citation></ref><ref id="R8"><label>8</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Permuth-Wey</surname><given-names>J</given-names></name><etal></etal></person-group><article-title>Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31</article-title><source>Nat Commun</source><year>2013</year><volume>4</volume><fpage>1627</fpage><pub-id pub-id-type="pmid">23535648</pub-id></element-citation></ref><ref id="R9"><label>9</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bojesen</surname><given-names>SE</given-names></name><etal></etal></person-group><article-title>Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer</article-title><source>Nat Genet</source><year>2013</year><volume>45</volume><fpage>371</fpage><lpage>384</lpage><fpage>384e371</fpage><lpage>384e372</lpage><pub-id pub-id-type="pmid">23535731</pub-id></element-citation></ref><ref id="R10"><label>10</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Couch</surname><given-names>FJ</given-names></name><etal></etal></person-group><article-title>Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers</article-title><source>Cancer Epidemiol Biomarkers Prev</source><year>2012</year><volume>21</volume><fpage>645</fpage><lpage>657</lpage><pub-id pub-id-type="pmid">22351618</pub-id></element-citation></ref><ref id="R11"><label>11</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ramus</surname><given-names>SJ</given-names></name><etal></etal></person-group><article-title>Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers</article-title><source>Hum Mutat</source><year>2012</year><volume>33</volume><fpage>690</fpage><lpage>702</lpage><pub-id pub-id-type="pmid">22253144</pub-id></element-citation></ref><ref id="R12"><label>12</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ramus</surname><given-names>SJ</given-names></name><etal></etal></person-group><article-title>Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers</article-title><source>J Natl Cancer Inst</source><year>2011</year><volume>103</volume><fpage>105</fpage><lpage>116</lpage><pub-id pub-id-type="pmid">21169536</pub-id></element-citation></ref><ref id="R13"><label>13</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Couch</surname><given-names>FJ</given-names></name><etal></etal></person-group><article-title>Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk</article-title><source>PLoS Genet</source><year>2013</year><volume>9</volume><fpage>e1003212</fpage><pub-id pub-id-type="pmid">23544013</pub-id></element-citation></ref><ref id="R14"><label>14</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bolton</surname><given-names>KL</given-names></name><name><surname>Ganda</surname><given-names>C</given-names></name><name><surname>Berchuck</surname><given-names>A</given-names></name><name><surname>Pharaoh</surname><given-names>PD</given-names></name><name><surname>Gayther</surname><given-names>SA</given-names></name></person-group><article-title>Role of common genetic variants in ovarian cancer susceptibility and outcome: progress to date from the Ovarian Cancer Association Consortium (OCAC)</article-title><source>J Intern Med</source><year>2012</year><volume>271</volume><fpage>366</fpage><lpage>378</lpage><pub-id pub-id-type="pmid">22443200</pub-id></element-citation></ref><ref id="R15"><label>15</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chenevix-Trench</surname><given-names>G</given-names></name><etal></etal></person-group><article-title>An international initiative to identify genetic modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers: the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA)</article-title><source>Breast Cancer Res</source><year>2007</year><volume>9</volume><fpage>104</fpage><pub-id pub-id-type="pmid">17466083</pub-id></element-citation></ref><ref id="R16"><label>16</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gaudet</surname><given-names>MM</given-names></name><etal></etal></person-group><article-title>Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk</article-title><source>PLoS Genet</source><year>2013</year><volume>9</volume><fpage>e1003173</fpage><pub-id pub-id-type="pmid">23544012</pub-id></element-citation></ref><ref id="R17"><label>17</label><element-citation publication-type="journal"><collab>Genomes Project, C</collab><etal></etal><article-title>An integrated map of genetic variation from 1,092 human genomes</article-title><source>Nature</source><year>2012</year><volume>491</volume><fpage>56</fpage><lpage>65</lpage><pub-id pub-id-type="pmid">23128226</pub-id></element-citation></ref><ref id="R18"><label>18</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Barnes</surname><given-names>DR</given-names></name><etal></etal></person-group><article-title>Evaluation of association methods for analysing modifiers of disease risk in carriers of high-risk mutations</article-title><source>Genet Epidemiol</source><year>2012</year><volume>36</volume><fpage>274</fpage><lpage>291</lpage><pub-id pub-id-type="pmid">22714938</pub-id></element-citation></ref><ref id="R19"><label>19</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bourguignon</surname><given-names>LY</given-names></name><name><surname>Gilad</surname><given-names>E</given-names></name><name><surname>Rothman</surname><given-names>K</given-names></name><name><surname>Peyrollier</surname><given-names>K</given-names></name></person-group><article-title>Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression</article-title><source>J Biol Chem</source><year>2005</year><volume>280</volume><fpage>11961</fpage><lpage>11972</lpage><pub-id pub-id-type="pmid">15655247</pub-id></element-citation></ref><ref id="R20"><label>20</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zuo</surname><given-names>Y</given-names></name><name><surname>Wu</surname><given-names>Y</given-names></name><name><surname>Chakraborty</surname><given-names>C</given-names></name></person-group><article-title>Cdc42 negatively regulates intrinsic migration of highly aggressive breast cancer cells</article-title><source>J Cell Physiol</source><year>2012</year><volume>227</volume><fpage>1399</fpage><lpage>1407</lpage><pub-id pub-id-type="pmid">21618528</pub-id></element-citation></ref><ref id="R21"><label>21</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pagliardini</surname><given-names>L</given-names></name><etal></etal></person-group><article-title>An Italian association study and meta-analysis with previous GWAS confirm WNT4, CDKN2BAS and FN1 as the first identified susceptibility loci for endometriosis</article-title><source>J Med Genet</source><year>2013</year><volume>50</volume><fpage>43</fpage><lpage>46</lpage><pub-id pub-id-type="pmid">23142796</pub-id></element-citation></ref><ref id="R22"><label>22</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pearce</surname><given-names>CL</given-names></name><etal></etal></person-group><article-title>Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies</article-title><source>Lancet Oncol</source><year>2012</year><volume>13</volume><fpage>385</fpage><lpage>394</lpage><pub-id pub-id-type="pmid">22361336</pub-id></element-citation></ref><ref id="R23"><label>23</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tomaselli</surname><given-names>S</given-names></name><etal></etal></person-group><article-title>Human RSPO1/R-spondin1 is expressed during early ovary development and augments beta-catenin signaling</article-title><source>PLoS One</source><year>2011</year><volume>6</volume><fpage>e16366</fpage><pub-id pub-id-type="pmid">21297984</pub-id></element-citation></ref><ref id="R24"><label>24</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Parma</surname><given-names>P</given-names></name><etal></etal></person-group><article-title>R-spondin1 is essential in sex determination, skin differentiation and malignancy</article-title><source>Nat Genet</source><year>2006</year><volume>38</volume><fpage>1304</fpage><lpage>1309</lpage><pub-id pub-id-type="pmid">17041600</pub-id></element-citation></ref><ref id="R25"><label>25</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tomizuka</surname><given-names>K</given-names></name><etal></etal></person-group><article-title>R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling</article-title><source>Hum Mol Genet</source><year>2008</year><volume>17</volume><fpage>1278</fpage><lpage>1291</lpage><pub-id pub-id-type="pmid">18250097</pub-id></element-citation></ref><ref id="R26"><label>26</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>De Ganck</surname><given-names>A</given-names></name><etal></etal></person-group><article-title>Multiple isoforms of the tumor suppressor myopodin are simultaneously transcribed in cancer cells</article-title><source>Biochem Biophys Res Commun</source><year>2008</year><volume>370</volume><fpage>269</fpage><lpage>273</lpage><pub-id pub-id-type="pmid">18371299</pub-id></element-citation></ref><ref id="R27"><label>27</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jing</surname><given-names>L</given-names></name><etal></etal></person-group><article-title>Expression of myopodin induces suppression of tumor growth and metastasis</article-title><source>Am J Pathol</source><year>2004</year><volume>164</volume><fpage>1799</fpage><lpage>1806</lpage><pub-id pub-id-type="pmid">15111326</pub-id></element-citation></ref><ref id="R28"><label>28</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lin</surname><given-names>F</given-names></name><etal></etal></person-group><article-title>Myopodin, a synaptopodin homologue, is frequently deleted in invasive prostate cancers</article-title><source>Am J Pathol</source><year>2001</year><volume>159</volume><fpage>1603</fpage><lpage>1612</lpage><pub-id pub-id-type="pmid">11696420</pub-id></element-citation></ref><ref id="R29"><label>29</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sanchez-Carbayo</surname><given-names>M</given-names></name><name><surname>Schwarz</surname><given-names>K</given-names></name><name><surname>Charytonowicz</surname><given-names>E</given-names></name><name><surname>Cordon-Cardo</surname><given-names>C</given-names></name><name><surname>Mundel</surname><given-names>P</given-names></name></person-group><article-title>Tumor suppressor role for myopodin in bladder cancer: loss of nuclear expression of myopodin is cell-cycle dependent and predicts clinical outcome</article-title><source>Oncogene</source><year>2003</year><volume>22</volume><fpage>5298</fpage><lpage>5305</lpage><pub-id pub-id-type="pmid">12917631</pub-id></element-citation></ref><ref id="R30"><label>30</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yu</surname><given-names>YP</given-names></name><name><surname>Luo</surname><given-names>JH</given-names></name></person-group><article-title>Myopodin-mediated suppression of prostate cancer cell migration involves interaction with zyxin</article-title><source>Cancer Res</source><year>2006</year><volume>66</volume><fpage>7414</fpage><lpage>7419</lpage><pub-id pub-id-type="pmid">16885336</pub-id></element-citation></ref><ref id="R31"><label>31</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Amundadottir</surname><given-names>L</given-names></name><etal></etal></person-group><article-title>Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer</article-title><source>Nat Genet</source><year>2009</year><volume>41</volume><fpage>986</fpage><lpage>990</lpage><pub-id pub-id-type="pmid">19648918</pub-id></element-citation></ref><ref id="R32"><label>32</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rummel</surname><given-names>S</given-names></name><name><surname>Shriver</surname><given-names>CD</given-names></name><name><surname>Ellsworth</surname><given-names>RE</given-names></name></person-group><article-title>Relationships between the ABO blood group SNP rs505922 and breast cancer phenotypes: a genotype-phenotype correlation study</article-title><source>BMC Med Genet</source><year>2012</year><volume>13</volume><fpage>41</fpage><pub-id pub-id-type="pmid">22642827</pub-id></element-citation></ref><ref id="R33"><label>33</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Poole</surname><given-names>EM</given-names></name><etal></etal></person-group><article-title>ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium</article-title><source>Cancer Causes Control</source><year>2012</year><volume>23</volume><fpage>1805</fpage><lpage>1810</lpage><pub-id pub-id-type="pmid">22961099</pub-id></element-citation></ref><ref id="R34"><label>34</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sikdar</surname><given-names>N</given-names></name><etal></etal></person-group><article-title>DNA damage responses by human ELG1 in S phase are important to maintain genomic integrity</article-title><source>Cell Cycle</source><year>2009</year><volume>8</volume><fpage>3199</fpage><lpage>3207</lpage><pub-id pub-id-type="pmid">19755857</pub-id></element-citation></ref><ref id="R35"><label>35</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bell</surname><given-names>DW</given-names></name><etal></etal></person-group><article-title>Predisposition to cancer caused by genetic and functional defects of mammalian Atad5</article-title><source>PLoS Genet</source><year>2011</year><volume>7</volume><fpage>e1002245</fpage><pub-id pub-id-type="pmid">21901109</pub-id></element-citation></ref><ref id="R36"><label>36</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lee</surname><given-names>KY</given-names></name><etal></etal></person-group><article-title>Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1</article-title><source>J Biol Chem</source><year>2010</year><volume>285</volume><fpage>10362</fpage><lpage>10369</lpage><pub-id pub-id-type="pmid">20147293</pub-id></element-citation></ref><ref id="R37"><label>37</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wacholder</surname><given-names>S</given-names></name><name><surname>Han</surname><given-names>SS</given-names></name><name><surname>Weinberg</surname><given-names>CR</given-names></name></person-group><article-title>Inference from a multiplicative model of joint genetic effects for [corrected] ovarian cancer risk</article-title><source>J Natl Cancer Inst</source><year>2011</year><volume>103</volume><fpage>82</fpage><lpage>83</lpage><pub-id pub-id-type="pmid">21169538</pub-id></element-citation></ref><ref id="R38"><label>38</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hnisz</surname><given-names>D</given-names></name><etal></etal></person-group><article-title>Super-enhancers in the control of cell identity and disease</article-title><source>Cell</source><year>2013</year><volume>155</volume><fpage>934</fpage><lpage>947</lpage><pub-id pub-id-type="pmid">24119843</pub-id></element-citation></ref><ref id="R39"><label>39</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Permuth-Wey</surname><given-names>J</given-names></name><etal></etal></person-group><article-title>LIN28B polymorphisms influence susceptibility to epithelial ovarian cancer</article-title><source>Cancer Res</source><year>2011</year><volume>71</volume><fpage>3896</fpage><lpage>3903</lpage><pub-id pub-id-type="pmid">21482675</pub-id></element-citation></ref><ref id="R40"><label>40</label><element-citation publication-type="journal"><article-title>GenABEL: genome-wide SNP association analysis</article-title><year>2013</year></element-citation></ref><ref id="R41"><label>41</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Delaneau</surname><given-names>O</given-names></name><name><surname>Marchini</surname><given-names>J</given-names></name><name><surname>Zagury</surname><given-names>JF</given-names></name></person-group><article-title>A linear complexity phasing method for thousands of genomes</article-title><source>Nature Methods</source><year>2012</year><volume>9</volume><fpage>179</fpage><lpage>181</lpage><comment>doi:</comment><pub-id pub-id-type="pmid">22138821</pub-id></element-citation></ref><ref id="R42"><label>42</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Howie</surname><given-names>BN</given-names></name><name><surname>Donnelly</surname><given-names>P</given-names></name><name><surname>Marchini</surname><given-names>J</given-names></name></person-group><article-title>A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies</article-title><source>Plos Genetics</source><year>2009</year><volume>5</volume><comment>doi:ARTN e1000529</comment></element-citation></ref><ref id="R43"><label>43</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Antoniou</surname><given-names>AC</given-names></name><etal></etal></person-group><article-title>RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies</article-title><source>Am J Hum Genet</source><year>2007</year><volume>81</volume><fpage>1186</fpage><lpage>1200</lpage><pub-id pub-id-type="pmid">17999359</pub-id></element-citation></ref><ref id="R44"><label>44</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Antoniou</surname><given-names>AC</given-names></name><etal></etal></person-group><article-title>A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population</article-title><source>Nat Genet</source><year>2010</year><volume>42</volume><fpage>885</fpage><lpage>892</lpage><pub-id pub-id-type="pmid">20852631</pub-id></element-citation></ref><ref id="R45"><label>45</label><element-citation publication-type="book"><source>R: A Language and Environment for Statistical Computing v. 3.0.1</source><year>2013</year><publisher-loc>Vienna, Austria</publisher-loc><publisher-name>R Foundation for Statistical Computing</publisher-name></element-citation></ref><ref id="R46"><label>46</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Udler</surname><given-names>MS</given-names></name><name><surname>Tyrer</surname><given-names>J</given-names></name><name><surname>Easton</surname><given-names>DF</given-names></name></person-group><article-title>Evaluating the power to discriminate between highly correlated SNPs in genetic association studies</article-title><source>Genet Epidemiol</source><year>2010</year><volume>34</volume><fpage>463</fpage><lpage>468</lpage><pub-id pub-id-type="pmid">20583289</pub-id></element-citation></ref><ref id="R47"><label>47</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Reumers</surname><given-names>J</given-names></name><etal></etal></person-group><article-title>Joint annotation of coding and non-coding single nucleotide polymorphisms and mutations in the SNP effect and PupaSuite databases</article-title><source>Nucleic Acids Res</source><year>2008</year><volume>36</volume><fpage>D825</fpage><lpage>D829</lpage><pub-id pub-id-type="pmid">18086700</pub-id></element-citation></ref><ref id="R48"><label>48</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Conde</surname><given-names>L</given-names></name><etal></etal></person-group><article-title>PupaSuite: finding functional single nucleotide polymorphisms for large-scale genotyping purposes</article-title><source>Nucleic Acids Res</source><year>2006</year><volume>34</volume><fpage>W621</fpage><lpage>W625</lpage><pub-id pub-id-type="pmid">16845085</pub-id></element-citation></ref><ref id="R49"><label>49</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mavaddat</surname><given-names>N</given-names></name><etal></etal></person-group><article-title>Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)</article-title><source>Cancer Epidemiol Biomarkers Prev</source><year>2012</year><volume>21</volume><fpage>134</fpage><lpage>147</lpage><pub-id pub-id-type="pmid">22144499</pub-id></element-citation></ref><ref id="R50"><label>50</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lakhani</surname><given-names>SR</given-names></name><etal></etal></person-group><article-title>Pathology of ovarian cancers in BRCA1 and BRCA2 carriers</article-title><source>Clin Cancer Res</source><year>2004</year><volume>10</volume><fpage>2473</fpage><lpage>2481</lpage><pub-id pub-id-type="pmid">15073127</pub-id></element-citation></ref><ref id="R51"><label>51</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rubin</surname><given-names>SC</given-names></name><etal></etal></person-group><article-title>Clinical and pathological features of ovarian cancer in women with germ-line mutations of BRCA1</article-title><source>N Engl J Med</source><year>1996</year><volume>335</volume><fpage>1413</fpage><lpage>1416</lpage><pub-id pub-id-type="pmid">8875917</pub-id></element-citation></ref><ref id="R52"><label>52</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Maehle</surname><given-names>L</given-names></name><etal></etal></person-group><article-title>High risk for ovarian cancer in a prospective series is restricted to BRCA1/2 mutation carriers</article-title><source>Clin Cancer Res</source><year>2008</year><volume>14</volume><fpage>7569</fpage><lpage>7573</lpage><pub-id pub-id-type="pmid">19010876</pub-id></element-citation></ref><ref id="R53"><label>53</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shaw</surname><given-names>PA</given-names></name><etal></etal></person-group><article-title>Histopathologic features of genetically determined ovarian cancer</article-title><source>Int J Gynecol Pathol</source><year>2002</year><volume>21</volume><fpage>407</fpage><lpage>411</lpage><pub-id pub-id-type="pmid">12352190</pub-id></element-citation></ref><ref id="R54"><label>54</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Willer</surname><given-names>CJ</given-names></name><name><surname>Li</surname><given-names>Y</given-names></name><name><surname>Abecasis</surname><given-names>GR</given-names></name></person-group><article-title>METAL: fast and efficient meta-analysis of genomewide association scans</article-title><source>Bioinformatics</source><year>2010</year><volume>26</volume><fpage>2190</fpage><lpage>2191</lpage><pub-id pub-id-type="pmid">20616382</pub-id></element-citation></ref><ref id="R55"><label>55</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname><given-names>NF</given-names></name><etal></etal></person-group><article-title>A modified medium that significantly improves the growth of human normal ovarian surface epithelial (OSE) cells in vitro</article-title><source>Lab Invest</source><year>2004</year><volume>84</volume><fpage>923</fpage><lpage>931</lpage><pub-id pub-id-type="pmid">15077121</pub-id></element-citation></ref><ref id="R56"><label>56</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fotheringham</surname><given-names>S</given-names></name><name><surname>Levanon</surname><given-names>K</given-names></name><name><surname>Drapkin</surname><given-names>R</given-names></name></person-group><article-title>Ex vivo culture of primary human fallopian tube epithelial cells</article-title><source>J Vis Exp</source><year>2011</year></element-citation></ref><ref id="R57"><label>57</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname><given-names>Q</given-names></name><etal></etal></person-group><article-title>Expressopn QTL based analyses reveal candidate causal genes and loci across five tumor types</article-title><source>Hum Mol Genet</source><year>2014</year><comment><bold>(in press)</bold></comment></element-citation></ref><ref id="R58"><label>58</label><element-citation publication-type="journal"><collab>Cancer Genome Atlas Research, N</collab><article-title>Integrated genomic analyses of ovarian carcinoma</article-title><source>Nature</source><year>2011</year><volume>474</volume><fpage>609</fpage><lpage>615</lpage><pub-id pub-id-type="pmid">21720365</pub-id></element-citation></ref><ref id="R59"><label>59</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Forbes</surname><given-names>SA</given-names></name><etal></etal></person-group><article-title>The Catalogue of Somatic Mutations in Cancer (COSMIC)</article-title><source>Curr Protoc Hum Genet</source><year>2008</year><volume>Chapter 10</volume><issue>Unit 10</issue><fpage>11</fpage><pub-id pub-id-type="pmid">18428421</pub-id></element-citation></ref><ref id="R60"><label>60</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gao</surname><given-names>J</given-names></name><etal></etal></person-group><article-title>Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal</article-title><source>Sci Signal</source><year>2013</year><volume>6</volume><fpage>pl1</fpage><pub-id pub-id-type="pmid">23550210</pub-id></element-citation></ref><ref id="R61"><label>61</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cerami</surname><given-names>E</given-names></name><etal></etal></person-group><article-title>The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data</article-title><source>Cancer Discov</source><year>2012</year><volume>2</volume><fpage>401</fpage><lpage>404</lpage><pub-id pub-id-type="pmid">22588877</pub-id></element-citation></ref><ref id="R62"><label>62</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lawrenson</surname><given-names>K</given-names></name><etal></etal></person-group><article-title>Senescent fibroblasts promote neoplastic transformation of partially transformed ovarian epithelial cells in a three-dimensional model of early stage ovarian cancer</article-title><source>Neoplasia</source><year>2010</year><volume>12</volume><fpage>317</fpage><lpage>325</lpage><pub-id pub-id-type="pmid">20360942</pub-id></element-citation></ref></ref-list></back><floats-group><fig id="F1" orientation="portrait" position="float"><label>Figure 1</label><caption><p id="P53">Hazard ratios for the association with EOC of 12 previously reported epithelial ovarian cancer susceptibility variants and the six novel susceptibility variants for OCAC, <italic>BRCA1</italic> mutation carriers and <italic>BRCA2</italic> mutation carriers</p></caption><graphic xlink:href="nihms647338f1"></graphic></fig><fig id="F2" orientation="portrait" position="float"><label>Figure 2</label><caption><p id="P54">The 1p36 epithelial ovarian cancer susceptibility locus</p><p id="P55">A) The Manhattan plot depicts the strength of association between all imputed and genotyped SNPs across the region bound by hg19 co-ordinates chr1:21922893-22991643. The dotted line represents the genome-wide significance level 5×10<sup>−8</sup>. Additional tracks show genes and enhancers in ovary as described in Hnisz et al<sup><xref rid="R38" ref-type="bibr">38</xref></sup>. Positions of SNPs for which imputation r<sup>2</sup><0.3 and/or minor allele frequency <0.005 are shown in the bottom track as ‘untyped’ SNPs.</p><p id="P56">B) The shaded iCHAV from (A) is shown depicting the genes and the location of the <italic>WNT4</italic> promoter construct as a red box. Red ticks show the positions of the putative causal variants following likelihood ratio testing. Signals from FAIRE-seq data derived from ovarian cells are represented by black marks, and the locations of predicted <italic>CDC42</italic> enhancers<sup><xref rid="R38" ref-type="bibr">38</xref></sup> as blue boxes. The positions of genotyped SNPs, and those that were neither genotyped nor well imputed (‘untyped’), are shown.</p><p id="P57">C) Normalised luciferase reporter activity following triplicate transfections of wildtype and risk haplotype <italic>WNT4</italic> promoter constructs in iOSE4 cells. Error bars represent standard error from three independent experiments.</p></caption><graphic xlink:href="nihms647338f2"></graphic></fig><table-wrap id="T1" position="float" orientation="landscape"><label>Table 1</label><caption><p id="P58">Association test results for loci associated at p<5×10<sup>−8</sup> in the second imputation stage. Results reported for ovarian cancer in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers, ovarian cancer as well as serous subtype in OCAC, the meta-analysis for ovarian cancer, and for the meta-analysis for all tumour histologies in <italic>BRCA1</italic> and <italic>BRCA2</italic> and serous ovarian cancer in OCAC. SNP with smallest p-value reported for each locus</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1"></th><th align="left" rowspan="1" colspan="1"></th><th align="left" rowspan="1" colspan="1"></th><th align="left" rowspan="1" colspan="1"></th><th align="left" rowspan="1" colspan="1"></th><th align="left" rowspan="1" colspan="1"></th><th align="left" colspan="3" valign="top" rowspan="1">OCAC all histologies</th><th align="left" colspan="2" valign="top" rowspan="1">OCAC serous</th><th align="left" colspan="3" valign="top" rowspan="1"><italic>BRCA1</italic> carriers</th><th align="left" colspan="3" valign="top" rowspan="1"><italic>BRCA2</italic> carriers</th><th align="left" rowspan="1" colspan="1">MA all histologies<xref ref-type="table-fn" rid="TFN2">1</xref></th><th align="left" valign="top" rowspan="1" colspan="1">MA serous<xref ref-type="table-fn" rid="TFN3">2</xref></th></tr><tr><th align="left" valign="top" rowspan="1" colspan="1">Loc<underline>n</underline></th><th align="left" rowspan="1" colspan="1">Nearest<break></break>gene</th><th align="left" valign="top" rowspan="1" colspan="1">rs#</th><th align="left" valign="top" rowspan="1" colspan="1">Ref<xref ref-type="table-fn" rid="TFN7">6</xref></th><th align="left" valign="top" rowspan="1" colspan="1">Eff<xref ref-type="table-fn" rid="TFN7">6</xref></th><th align="left" valign="top" rowspan="1" colspan="1">EAF<xref ref-type="table-fn" rid="TFN8">7</xref></th><th align="left" valign="top" rowspan="1" colspan="1">r<sup>2</sup><xref ref-type="table-fn" rid="TFN1">*</xref></th><th align="left" valign="top" rowspan="1" colspan="1">OR (95%CI)</th><th align="left" valign="top" rowspan="1" colspan="1">P</th><th align="left" valign="top" rowspan="1" colspan="1">OR (95%CI)</th><th align="left" valign="top" rowspan="1" colspan="1">P</th><th align="left" valign="top" rowspan="1" colspan="1">r<sup>2</sup><xref ref-type="table-fn" rid="TFN1">*</xref></th><th align="left" valign="top" rowspan="1" colspan="1">HR (95%CI)</th><th align="left" valign="top" rowspan="1" colspan="1">P</th><th align="left" valign="top" rowspan="1" colspan="1">r<sup>2</sup><xref ref-type="table-fn" rid="TFN1">*</xref></th><th align="left" valign="top" rowspan="1" colspan="1">HR (95%CI)</th><th align="left" valign="top" rowspan="1" colspan="1">P</th><th align="left" valign="top" rowspan="1" colspan="1">P</th><th align="left" valign="top" rowspan="1" colspan="1">P</th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">1p36</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>WNT4</italic></td><td align="left" valign="top" rowspan="1" colspan="1">rs56318008</td><td align="left" valign="top" rowspan="1" colspan="1">C</td><td align="left" valign="top" rowspan="1" colspan="1">T</td><td align="left" valign="top" rowspan="1" colspan="1">0.15</td><td align="left" valign="top" rowspan="1" colspan="1">0.98</td><td align="left" valign="top" rowspan="1" colspan="1">1.11<break></break>(1.07–1.16)</td><td align="left" valign="top" rowspan="1" colspan="1">3.9×10<sup>−7</sup></td><td align="left" valign="top" rowspan="1" colspan="1">1.12<break></break>(1.07–1.18)</td><td align="left" valign="top" rowspan="1" colspan="1"><bold>3.1×10</bold><sup>−6</sup></td><td align="left" valign="top" rowspan="1" colspan="1">0.98</td><td align="left" valign="top" rowspan="1" colspan="1">1.15<break></break>(1.05–1.26)</td><td align="left" valign="top" rowspan="1" colspan="1">3.1×10<sup>−3</sup></td><td align="left" valign="top" rowspan="1" colspan="1">0.98</td><td align="left" valign="top" rowspan="1" colspan="1">1.03<break></break>(0.86–1.23)</td><td align="left" valign="top" rowspan="1" colspan="1">0.74</td><td align="left" valign="top" rowspan="1" colspan="1">7.6×10<sup>−9</sup></td><td align="left" valign="top" rowspan="1" colspan="1">5.7×10<sup>−8</sup></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">1p34.3</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>RSPO1</italic></td><td align="left" valign="top" rowspan="1" colspan="1">rs58722170</td><td align="left" valign="top" rowspan="1" colspan="1">G</td><td align="left" valign="top" rowspan="1" colspan="1">C</td><td align="left" valign="top" rowspan="1" colspan="1">0.23</td><td align="left" valign="top" rowspan="1" colspan="1">0.85</td><td align="left" valign="top" rowspan="1" colspan="1">1.08<break></break>(1.04–1.12)</td><td align="left" valign="top" rowspan="1" colspan="1">9.7×10<sup>−5</sup></td><td align="left" valign="top" rowspan="1" colspan="1">1.12<break></break>(1.08–1.18)</td><td align="left" valign="top" rowspan="1" colspan="1">1.1×10<sup>−7</sup></td><td align="left" valign="top" rowspan="1" colspan="1">0.83</td><td align="left" valign="top" rowspan="1" colspan="1">1.14<break></break>(1.05–1.23)</td><td align="left" valign="top" rowspan="1" colspan="1">1.5×10<sup>−3</sup></td><td align="left" valign="top" rowspan="1" colspan="1">0.83</td><td align="left" valign="top" rowspan="1" colspan="1">1.35<break></break>(1.17–1.57)</td><td align="left" valign="top" rowspan="1" colspan="1">5.2×10<sup>−5</sup></td><td align="left" valign="top" rowspan="1" colspan="1">1.6×10<sup>−8</sup></td><td align="left" valign="top" rowspan="1" colspan="1">2.7×10<sup>−12</sup></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">4q26</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>SYNPO2</italic></td><td align="left" valign="top" rowspan="1" colspan="1">rs17329882</td><td align="left" valign="top" rowspan="1" colspan="1">A</td><td align="left" valign="top" rowspan="1" colspan="1">C</td><td align="left" valign="top" rowspan="1" colspan="1">0.24</td><td align="left" valign="top" rowspan="1" colspan="1">0.95</td><td align="left" valign="top" rowspan="1" colspan="1">1.09<break></break>(1.06–1.13)</td><td align="left" valign="top" rowspan="1" colspan="1">5.9×10<sup>−7</sup></td><td align="left" valign="top" rowspan="1" colspan="1">1.11<break></break>(1.07–1.16)</td><td align="left" valign="top" rowspan="1" colspan="1">6.4×10<sup>−7</sup></td><td align="left" valign="top" rowspan="1" colspan="1">0.93</td><td align="left" valign="top" rowspan="1" colspan="1">1.08<break></break>(1.00–1.17)</td><td align="left" valign="top" rowspan="1" colspan="1">0.042</td><td align="left" valign="top" rowspan="1" colspan="1">0.93</td><td align="left" valign="top" rowspan="1" colspan="1">1.15<break></break>(1.00–1.33)</td><td align="left" valign="top" rowspan="1" colspan="1">0.06</td><td align="left" valign="top" rowspan="1" colspan="1">1.4×10<sup>−8</sup></td><td align="left" valign="top" rowspan="1" colspan="1">1.6×10<sup>−8</sup></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">6p22.1</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>GPX6</italic></td><td align="left" valign="top" rowspan="1" colspan="1">rs116133110<xref ref-type="table-fn" rid="TFN5">4</xref></td><td align="left" valign="top" rowspan="1" colspan="1">T</td><td align="left" valign="top" rowspan="1" colspan="1">C</td><td align="left" valign="top" rowspan="1" colspan="1">0.31</td><td align="left" valign="top" rowspan="1" colspan="1">0.99</td><td align="left" valign="top" rowspan="1" colspan="1">0.93<break></break>(0.91–0.97)</td><td align="left" valign="top" rowspan="1" colspan="1">9.0×10<sup>−5</sup></td><td align="left" valign="top" rowspan="1" colspan="1">0.91<break></break>(0.87–0.94)</td><td align="left" valign="top" rowspan="1" colspan="1">2.6×10<sup>−7</sup></td><td align="left" valign="top" rowspan="1" colspan="1">0.99</td><td align="left" valign="top" rowspan="1" colspan="1">0.92<break></break>(0.86–0.99)</td><td align="left" valign="top" rowspan="1" colspan="1">0.023</td><td align="left" valign="top" rowspan="1" colspan="1">0.99</td><td align="left" valign="top" rowspan="1" colspan="1">0.97<break></break>(0.85–1.10)</td><td align="left" valign="top" rowspan="1" colspan="1">0.64</td><td align="left" valign="top" rowspan="1" colspan="1">6.8×10<sup>−6</sup></td><td align="left" valign="top" rowspan="1" colspan="1">3.0×10<sup>−8</sup></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">9q34.2</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>ABO</italic></td><td align="left" valign="top" rowspan="1" colspan="1">rs635634</td><td align="left" valign="top" rowspan="1" colspan="1">C</td><td align="left" valign="top" rowspan="1" colspan="1">T</td><td align="left" valign="top" rowspan="1" colspan="1">0.19</td><td align="left" valign="top" rowspan="1" colspan="1">0.85</td><td align="left" valign="top" rowspan="1" colspan="1">1.11<break></break>(1.07–1.16)</td><td align="left" valign="top" rowspan="1" colspan="1">1.1×10<sup>−7</sup></td><td align="left" valign="top" rowspan="1" colspan="1">1.12<break></break>(1.08–1.18)</td><td align="left" valign="top" rowspan="1" colspan="1">1.0×10<sup>−6</sup></td><td align="left" valign="top" rowspan="1" colspan="1">0.83</td><td align="left" valign="top" rowspan="1" colspan="1">1.11<break></break>(1.02–1.21)</td><td align="left" valign="top" rowspan="1" colspan="1">0.012</td><td align="left" valign="top" rowspan="1" colspan="1">0.83</td><td align="left" valign="top" rowspan="1" colspan="1">1.05<break></break>(0.89–1.23)</td><td align="left" valign="top" rowspan="1" colspan="1">0.55</td><td align="left" valign="top" rowspan="1" colspan="1">4.4×10<sup>−9</sup></td><td align="left" valign="top" rowspan="1" colspan="1">4.2×10<sup>−8</sup></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">17q11.2</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>ATAD5</italic></td><td align="left" valign="top" rowspan="1" colspan="1">chr17:29181220:I<xref ref-type="table-fn" rid="TFN6">5</xref></td><td align="left" valign="top" rowspan="1" colspan="1">A</td><td align="left" valign="top" rowspan="1" colspan="1">AT</td><td align="left" valign="top" rowspan="1" colspan="1">0.28</td><td align="left" valign="top" rowspan="1" colspan="1">0.95</td><td align="left" valign="top" rowspan="1" colspan="1">0.91<break></break>(0.88–0.94)</td><td align="left" valign="top" rowspan="1" colspan="1">5.4×10<sup>−9</sup></td><td align="left" valign="top" rowspan="1" colspan="1">0.91<break></break>(0.87–0.94)</td><td align="left" valign="top" rowspan="1" colspan="1">8.1×10<sup>−7</sup></td><td align="left" valign="top" rowspan="1" colspan="1">0.94</td><td align="left" valign="top" rowspan="1" colspan="1">1.01<break></break>(0.94–1.08)</td><td align="left" valign="top" rowspan="1" colspan="1">0.88</td><td align="left" valign="top" rowspan="1" colspan="1">0.93</td><td align="left" valign="top" rowspan="1" colspan="1">0.92<break></break>(0.80–1.05)</td><td align="left" valign="top" rowspan="1" colspan="1">0.23</td><td align="left" valign="top" rowspan="1" colspan="1">2.6×10<sup>−9</sup><xref ref-type="table-fn" rid="TFN4">*3</xref></td><td align="left" valign="top" rowspan="1" colspan="1">3.9×10<sup>−7</sup><xref ref-type="table-fn" rid="TFN4">*3</xref></td></tr></tbody></table><table-wrap-foot><fn id="TFN1"><label>*</label><p id="P59">Imputation accuracy r<sup>2</sup> estimate</p></fn><fn id="TFN2"><label>1</label><p id="P60">P-value from the meta-analysis association test for ovarian cancer in OCAC and <italic>BRCA1</italic> and <italic>BRCA2</italic> carriers</p></fn><fn id="TFN3"><label>2</label><p id="P61">P-value from the meta-analysis association test for ovarian cancer in <italic>BRCA1</italic> and <italic>BRCA2</italic> carriers and serous ovarian cancer in OCAC</p></fn><fn id="TFN4"><label>*3</label><p id="P62">meta-analysis of ovarian cancer associations in <italic>BRCA2</italic> carriers and OCAC only</p></fn><fn id="TFN5"><label>4</label><p id="P63">rs116133110 listed as rs6456822 on dbSNP</p></fn><fn id="TFN6"><label>5</label><p id="P64">chr17:29181220:I listed as rs199661266 on dbSNP</p></fn><fn id="TFN7"><label>6</label><p id="P65">Reference and effect allele</p></fn><fn id="TFN8"><label>7</label><p id="P66">Effect allele frequency</p></fn></table-wrap-foot></table-wrap><table-wrap id="T2" position="float" orientation="landscape"><label>Table 2</label><caption><p id="P67">Associations with ovarian cancer subtypes in OCAC samples for loci associated with ovarian cancer at p<5×10<sup>−8</sup> in the meta-analysis</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1"></th><th align="left" rowspan="1" colspan="1"></th><th align="left" colspan="2" rowspan="1">All histologies</th><th align="left" colspan="2" rowspan="1">Serous</th><th align="left" colspan="2" rowspan="1">Endometrioid</th><th align="left" colspan="2" rowspan="1">Clear cell</th><th align="left" colspan="2" rowspan="1">Mucinous</th><th align="left" rowspan="1" colspan="1"></th></tr><tr><th align="left" rowspan="1" colspan="1">Locus</th><th align="left" rowspan="1" colspan="1">rs#</th><th align="left" rowspan="1" colspan="1">OR (95%CI)</th><th align="left" rowspan="1" colspan="1">P</th><th align="left" rowspan="1" colspan="1">OR (95%CI)</th><th align="left" rowspan="1" colspan="1">P</th><th align="left" rowspan="1" colspan="1">OR (95%CI)</th><th align="left" rowspan="1" colspan="1">P</th><th align="left" rowspan="1" colspan="1">OR (95%CI)</th><th align="left" rowspan="1" colspan="1">P</th><th align="left" rowspan="1" colspan="1">OR (95%CI)</th><th align="left" rowspan="1" colspan="1">P</th><th align="left" rowspan="1" colspan="1">p-het<xref ref-type="table-fn" rid="TFN9">*</xref></th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">1p36</td><td align="left" valign="top" rowspan="1" colspan="1">rs56318008</td><td align="left" valign="top" rowspan="1" colspan="1">1.11<break></break>(1.06–1.15)</td><td align="left" valign="top" rowspan="1" colspan="1">8×10<sup>−7</sup></td><td align="left" valign="top" rowspan="1" colspan="1">1.12<break></break>(1.06–1.17)</td><td align="left" valign="top" rowspan="1" colspan="1">6×10<sup>−6</sup></td><td align="left" valign="top" rowspan="1" colspan="1">1.09<break></break>(1.00–1.19)</td><td align="left" valign="top" rowspan="1" colspan="1">0.05</td><td align="left" valign="top" rowspan="1" colspan="1">1.24<break></break>(1.10–1.39</td><td align="left" valign="top" rowspan="1" colspan="1">5×10<sup>−4</sup></td><td align="left" valign="top" rowspan="1" colspan="1">1.03<break></break>(0.91–1.17)</td><td align="left" valign="top" rowspan="1" colspan="1">0.65</td><td align="left" valign="top" rowspan="1" colspan="1">0.22</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">1p34.3</td><td align="left" valign="top" rowspan="1" colspan="1">rs58722170</td><td align="left" valign="top" rowspan="1" colspan="1">1.07<break></break>(1.03–1.11)</td><td align="left" valign="top" rowspan="1" colspan="1">2×10<sup>−4</sup></td><td align="left" valign="top" rowspan="1" colspan="1">1.12<break></break>(1.07–1.17)</td><td align="left" valign="top" rowspan="1" colspan="1">4×10<sup>−7</sup></td><td align="left" valign="top" rowspan="1" colspan="1">0.94<break></break>(0.87–1.02)</td><td align="left" valign="top" rowspan="1" colspan="1">0.16</td><td align="left" valign="top" rowspan="1" colspan="1">1.00<break></break>(0.89–1.12)</td><td align="left" valign="top" rowspan="1" colspan="1">0.98</td><td align="left" valign="top" rowspan="1" colspan="1">1.08<break></break>(0.97–1.21)</td><td align="left" valign="top" rowspan="1" colspan="1">0.17</td><td align="left" valign="top" rowspan="1" colspan="1">0.001</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">4q26</td><td align="left" valign="top" rowspan="1" colspan="1">rs17329882</td><td align="left" valign="top" rowspan="1" colspan="1">1.09<break></break>(1.06–1.13)</td><td align="left" valign="top" rowspan="1" colspan="1">3×10<sup>−7</sup></td><td align="left" valign="top" rowspan="1" colspan="1">1.11<break></break>(1.07–1.16)</td><td align="left" valign="top" rowspan="1" colspan="1">3×10<sup>−7</sup></td><td align="left" valign="top" rowspan="1" colspan="1">1.09<break></break>(1.01–1.18)</td><td align="left" valign="top" rowspan="1" colspan="1">0.020</td><td align="left" valign="top" rowspan="1" colspan="1">1.06<break></break>(0.96–1.18)</td><td align="left" valign="top" rowspan="1" colspan="1">0.26</td><td align="left" valign="top" rowspan="1" colspan="1">1.11<break></break>(0.99–1.23)</td><td align="left" valign="top" rowspan="1" colspan="1">0.06</td><td align="left" valign="top" rowspan="1" colspan="1">0.88</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">6p22.1</td><td align="left" valign="top" rowspan="1" colspan="1">rs116133110</td><td align="left" valign="top" rowspan="1" colspan="1">0.94<break></break>(0.91–0.97)</td><td align="left" valign="top" rowspan="1" colspan="1">9×10<sup>−5</sup></td><td align="left" valign="top" rowspan="1" colspan="1">0.91<break></break>(0.87–0.94)</td><td align="left" valign="top" rowspan="1" colspan="1">3×10<sup>−7</sup></td><td align="left" valign="top" rowspan="1" colspan="1">0.95<break></break>(0.89–1.02)</td><td align="left" valign="top" rowspan="1" colspan="1">0.16</td><td align="left" valign="top" rowspan="1" colspan="1">1.05<break></break>(0.95–1.15)</td><td align="left" valign="top" rowspan="1" colspan="1">0.34</td><td align="left" valign="top" rowspan="1" colspan="1">1.03<break></break>(0.94–1.14)</td><td align="left" valign="top" rowspan="1" colspan="1">0.53</td><td align="left" valign="top" rowspan="1" colspan="1">0.008</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">9q34.2</td><td align="left" valign="top" rowspan="1" colspan="1">rs635634</td><td align="left" valign="top" rowspan="1" colspan="1">1.12<break></break>(1.08–1.16)</td><td align="left" valign="top" rowspan="1" colspan="1">9×10<sup>−9</sup></td><td align="left" valign="top" rowspan="1" colspan="1">1.13<break></break>(1.08–1.18)</td><td align="left" valign="top" rowspan="1" colspan="1">2×10<sup>−7</sup></td><td align="left" valign="top" rowspan="1" colspan="1">1.12<break></break>(1.03–1.21)</td><td align="left" valign="top" rowspan="1" colspan="1">0.007</td><td align="left" valign="top" rowspan="1" colspan="1">1.03<break></break>(0.92–1.16)</td><td align="left" valign="top" rowspan="1" colspan="1">0.58</td><td align="left" valign="top" rowspan="1" colspan="1">1.23<break></break>(1.10–1.38)</td><td align="left" valign="top" rowspan="1" colspan="1">3×10<sup>−4</sup></td><td align="left" valign="top" rowspan="1" colspan="1">0.23</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">17q11.2</td><td align="left" valign="top" rowspan="1" colspan="1">chr17:29181<break></break>220:I</td><td align="left" valign="top" rowspan="1" colspan="1">0.90<break></break>(0.87–0.93)</td><td align="left" valign="top" rowspan="1" colspan="1">1×10<sup>−9</sup></td><td align="left" valign="top" rowspan="1" colspan="1">0.90<break></break>(0.87–0.94)</td><td align="left" valign="top" rowspan="1" colspan="1">2×10<sup>−7</sup></td><td align="left" valign="top" rowspan="1" colspan="1">0.88<break></break>(0.82–0.95)</td><td align="left" valign="top" rowspan="1" colspan="1">5×10<sup>−4</sup></td><td align="left" valign="top" rowspan="1" colspan="1">0.88<break></break>(0.80–0.98)</td><td align="left" valign="top" rowspan="1" colspan="1">0.020</td><td align="left" valign="top" rowspan="1" colspan="1">1.01<break></break>(0.91–1.12)</td><td align="left" valign="top" rowspan="1" colspan="1">0.84</td><td align="left" valign="top" rowspan="1" colspan="1">0.18</td></tr></tbody></table><table-wrap-foot><fn id="TFN9"><label>*</label><p id="P68">p-value for the heterogeneity in associations with different tumour subtypes</p></fn></table-wrap-foot></table-wrap><table-wrap id="T3" position="float" orientation="landscape"><label>Table 3</label><caption><p id="P69">Summary of data on SNPs, closest gene and all genes in 1 MB region for each locus</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" valign="top" rowspan="1" colspan="1">Loci</th><th align="center" valign="top" rowspan="1" colspan="1">Position of<break></break>top SNP</th><th align="center" valign="top" rowspan="1" colspan="1">#<break></break>putatively<break></break>causal<break></break>SNPs</th><th align="center" valign="top" rowspan="1" colspan="1">Genes in window of<break></break>putatively causal SNPs</th><th align="center" valign="top" rowspan="1" colspan="1"># SNPs<break></break>aligned w/<break></break>biofeatures<xref ref-type="table-fn" rid="TFN11">♭</xref></th><th align="center" valign="top" rowspan="1" colspan="1">Normal<break></break>eQTL<break></break>closest<break></break>gene</th><th align="center" valign="top" rowspan="1" colspan="1">Tumour<break></break>DNA<break></break>copy<break></break>number</th><th align="center" rowspan="1" colspan="1">Significant<break></break>expression<break></break>difference<break></break>in tumour<break></break>vs normal</th><th align="center" rowspan="1" colspan="1">Known<break></break>role of<break></break>gene<break></break>in<break></break>cancer</th><th align="center" rowspan="1" colspan="1">#<break></break>Genes<break></break>in<break></break>1MB<break></break>region</th><th align="center" valign="top" rowspan="1" colspan="1">Other known<break></break>cancer genes in<break></break>1MB region</th></tr></thead><tbody><tr><td align="center" valign="bottom" rowspan="1" colspan="1">1p36</td><td align="center" valign="bottom" rowspan="1" colspan="1">promoter<break></break>region of<break></break><italic>WNT4</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">39</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>WNT4, CDC42</italic>,<break></break><italic>LINC00339</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">11</td><td align="center" valign="bottom" rowspan="1" colspan="1">NS</td><td align="center" valign="bottom" rowspan="1" colspan="1">loss</td><td align="center" valign="bottom" rowspan="1" colspan="1"></td><td align="center" valign="bottom" rowspan="1" colspan="1">Yes</td><td align="center" valign="bottom" rowspan="1" colspan="1">11</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>RAP1GAP, CDC42</italic></td></tr><tr><td align="center" valign="bottom" rowspan="1" colspan="1">1p34.3</td><td align="center" valign="bottom" rowspan="1" colspan="1">intron 3 of<break></break><italic>RSPO1</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">15</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>RSPO1</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">0</td><td align="center" valign="bottom" rowspan="1" colspan="1">NS</td><td align="center" valign="bottom" rowspan="1" colspan="1">gain</td><td align="center" valign="bottom" rowspan="1" colspan="1"></td><td align="center" valign="bottom" rowspan="1" colspan="1">Yes</td><td align="center" valign="bottom" rowspan="1" colspan="1">22</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>C1orf109, FHL3</italic></td></tr><tr><td align="center" valign="bottom" rowspan="1" colspan="1">4q26</td><td align="center" valign="bottom" rowspan="1" colspan="1">intron 3 of<break></break><italic>SYNPO2</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">4</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>SYNPO2</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">2</td><td align="center" valign="bottom" rowspan="1" colspan="1">NS<xref ref-type="table-fn" rid="TFN13">**</xref></td><td align="center" valign="bottom" rowspan="1" colspan="1">loss</td><td align="center" valign="bottom" rowspan="1" colspan="1">down</td><td align="center" valign="bottom" rowspan="1" colspan="1">Yes</td><td align="center" valign="bottom" rowspan="1" colspan="1">12</td><td align="center" valign="bottom" rowspan="1" colspan="1">none</td></tr><tr><td align="center" valign="bottom" rowspan="1" colspan="1">6p22.1</td><td align="center" valign="bottom" rowspan="1" colspan="1">intron 1 of<break></break><italic>GPX6</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">22</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>GPX6, GPX5</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">1</td><td align="center" valign="bottom" rowspan="1" colspan="1">N/A</td><td align="center" valign="bottom" rowspan="1" colspan="1">gain</td><td align="center" valign="bottom" rowspan="1" colspan="1"></td><td align="center" valign="bottom" rowspan="1" colspan="1"></td><td align="center" valign="bottom" rowspan="1" colspan="1">23</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>ZKSCAN3, TRIM27</italic></td></tr><tr><td align="center" valign="bottom" rowspan="1" colspan="1">9q34.2</td><td align="center" valign="bottom" rowspan="1" colspan="1">4.3kb<break></break>upstream of<break></break><italic>ABO</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">18</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>ABO, SLC2A6<xref ref-type="table-fn" rid="TFN12">*</xref></italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">1</td><td align="center" valign="bottom" rowspan="1" colspan="1">NS</td><td align="center" valign="bottom" rowspan="1" colspan="1">loss</td><td align="center" valign="bottom" rowspan="1" colspan="1">down</td><td align="center" valign="bottom" rowspan="1" colspan="1">Yes</td><td align="center" valign="bottom" rowspan="1" colspan="1">32</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>TSC1, RALGDS</italic>,<break></break><italic>RPL7A, VAV2</italic></td></tr><tr><td align="center" valign="bottom" rowspan="1" colspan="1">17q11.2</td><td align="center" valign="bottom" rowspan="1" colspan="1">intron 6 of<break></break><italic>ATAD5</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">16</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>ATAD5, TEFM, ADAP2</italic>,<break></break><italic>CRLF3, SUZ12P1</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">0</td><td align="center" valign="bottom" rowspan="1" colspan="1">NS</td><td align="center" valign="bottom" rowspan="1" colspan="1">loss</td><td align="center" valign="bottom" rowspan="1" colspan="1">up</td><td align="center" valign="bottom" rowspan="1" colspan="1">Yes</td><td align="center" valign="bottom" rowspan="1" colspan="1">17</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>NF1</italic></td></tr></tbody></table><table-wrap-foot><fn id="TFN10"><p id="P70">Proximal promoter regions were defined as 1kb upstream of the transcription start site</p><p id="P71">N/A indicated no expression of <italic>GPX6</italic> in normal tissues. NS, not significant.</p></fn><fn id="TFN11"><label>♭</label><p id="P72">Biofeatures defined as open chromatin, H3K4me3 or H3K27ac marks detected in normal ovarian and/or fallopian cells</p></fn><fn id="TFN12"><label>*</label><p id="P73">There are 16 genes in this region; <italic>ABO, SURF6, MED22, RPL7A, SNORD24, SNORD36B, SNORD36A, SNORD36C, SURF1, SURF2, SURF4, C9orf96, REXO4, ADAMTS13, CACFD1, SLC2A6,</italic> however all SNPs are within or upstream of <italic>ABO</italic> or upstream of <italic>SLC2A6</italic>.</p></fn><fn id="TFN13"><label>**</label><p id="P74">Trend p=0.067</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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