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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Common variants associated with plasma triglycerides and risk for coronary artery disease</title><author><name sortKey="Do, Ron" sort="Do, Ron" uniqKey="Do R" first="Ron" last="Do">Ron Do</name><affiliation><nlm:aff id="A1">Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA</nlm:aff></affiliation></author><author><name sortKey="Willer, Cristen J" sort="Willer, Cristen J" uniqKey="Willer C" first="Cristen J." last="Willer">Cristen J. Willer</name><affiliation><nlm:aff id="A5">Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Ellen M" sort="Schmidt, Ellen M" uniqKey="Schmidt E" first="Ellen M." last="Schmidt">Ellen M. Schmidt</name><affiliation><nlm:aff id="A6">Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Sengupta, Sebanti" sort="Sengupta, Sebanti" uniqKey="Sengupta S" first="Sebanti" last="Sengupta">Sebanti Sengupta</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Gao, Chi" sort="Gao, Chi" uniqKey="Gao C" first="Chi" last="Gao">Chi Gao</name><affiliation><nlm:aff id="A1">Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA</nlm:aff></affiliation></author><author><name sortKey="Peloso, Gina M" sort="Peloso, Gina M" uniqKey="Peloso G" first="Gina M." last="Peloso">Gina M. Peloso</name><affiliation><nlm:aff id="A2">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Gustafsson, Stefan" sort="Gustafsson, Stefan" uniqKey="Gustafsson S" first="Stefan" last="Gustafsson">Stefan Gustafsson</name><affiliation><nlm:aff id="A10">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Science for Life Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kanoni, Stavroula" sort="Kanoni, Stavroula" uniqKey="Kanoni S" first="Stavroula" last="Kanoni">Stavroula Kanoni</name><affiliation><nlm:aff id="A12">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Ganna, Andrea" sort="Ganna, Andrea" uniqKey="Ganna A" first="Andrea" last="Ganna">Andrea Ganna</name><affiliation><nlm:aff id="A10">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Science for Life Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Chen, Jin" sort="Chen, Jin" uniqKey="Chen J" first="Jin" last="Chen">Jin Chen</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Buchkovich, Martin L" sort="Buchkovich, Martin L" uniqKey="Buchkovich M" first="Martin L." last="Buchkovich">Martin L. Buchkovich</name><affiliation><nlm:aff id="A14">Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 USA</nlm:aff></affiliation></author><author><name sortKey="Mora, Samia" sort="Mora, Samia" uniqKey="Mora S" first="Samia" last="Mora">Samia Mora</name><affiliation><nlm:aff id="A15">Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave., Boston MA 02215, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Harvard Medical School, Boston MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Jacques S" sort="Beckmann, Jacques S" uniqKey="Beckmann J" first="Jacques S." last="Beckmann">Jacques S. Beckmann</name><affiliation><nlm:aff id="A17">Service of Medical Genetics, Lausanne University Hospital, Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Bragg Gresham, Jennifer L" sort="Bragg Gresham, Jennifer L" uniqKey="Bragg Gresham J" first="Jennifer L." last="Bragg-Gresham">Jennifer L. Bragg-Gresham</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Chang, Hsing Yi" sort="Chang, Hsing Yi" uniqKey="Chang H" first="Hsing-Yi" last="Chang">Hsing-Yi Chang</name><affiliation><nlm:aff id="A19">Division of Preventive Medicine and Health Services Research, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Demirkan, Ay E" sort="Demirkan, Ay E" uniqKey="Demirkan A" first="Ay E" last="Demirkan">Ay E Demirkan</name><affiliation><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Den Hertog, Heleen M" sort="Den Hertog, Heleen M" uniqKey="Den Hertog H" first="Heleen M." last="Den Hertog">Heleen M. Den Hertog</name><affiliation><nlm:aff id="A21">Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Donnelly, Louise A" sort="Donnelly, Louise A" uniqKey="Donnelly L" first="Louise A." last="Donnelly">Louise A. Donnelly</name><affiliation><nlm:aff id="A22">Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School. Dundee, DD1 9SY, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Ehret, Georg B" sort="Ehret, Georg B" uniqKey="Ehret G" first="Georg B." last="Ehret">Georg B. Ehret</name><affiliation><nlm:aff id="A23">Cardiology, Department of Specialities of Medicine, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA</nlm:aff></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation><nlm:aff id="A4">Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A25">Estonian Genome Center of the University of Tartu, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Feitosa, Mary F" sort="Feitosa, Mary F" uniqKey="Feitosa M" first="Mary F." last="Feitosa">Mary F. Feitosa</name><affiliation><nlm:aff id="A27">Department of Genetics, Washington University School of Medicine, USA</nlm:aff></affiliation></author><author><name sortKey="Ferreira, Teresa" sort="Ferreira, Teresa" uniqKey="Ferreira T" first="Teresa" last="Ferreira">Teresa Ferreira</name><affiliation><nlm:aff id="A28">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name><affiliation><nlm:aff id="A25">Estonian Genome Center of the University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Fontanillas, Pierre" sort="Fontanillas, Pierre" uniqKey="Fontanillas P" first="Pierre" last="Fontanillas">Pierre Fontanillas</name><affiliation><nlm:aff id="A4">Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA</nlm:aff></affiliation></author><author><name sortKey="Fraser, Ross M" sort="Fraser, Ross M" uniqKey="Fraser R" first="Ross M." last="Fraser">Ross M. Fraser</name><affiliation><nlm:aff id="A29">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Freitag, Daniel F" sort="Freitag, Daniel F" uniqKey="Freitag D" first="Daniel F." last="Freitag">Daniel F. Freitag</name><affiliation><nlm:aff id="A30">Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Gurdasani, Deepti" sort="Gurdasani, Deepti" uniqKey="Gurdasani D" first="Deepti" last="Gurdasani">Deepti Gurdasani</name><affiliation><nlm:aff id="A12">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Heikkil, Kauko" sort="Heikkil, Kauko" uniqKey="Heikkil K" first="Kauko" last="Heikkil">Kauko Heikkil</name><affiliation><nlm:aff id="A31">Hjelt Institute, Department of Public Health, University of Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><affiliation><nlm:aff id="A32">Centre For Paediatric Epidemiology and Biostatistics/MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name><affiliation><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Centre for Medical Systems Biology, Leiden, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Jackson, Anne U" sort="Jackson, Anne U" uniqKey="Jackson A" first="Anne U." last="Jackson">Anne U. Jackson</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation><nlm:aff id="A34">Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A35">Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name><affiliation><nlm:aff id="A36">Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Clinical Pharmacology, NIHR Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kaakinen, Marika" sort="Kaakinen, Marika" uniqKey="Kaakinen M" first="Marika" last="Kaakinen">Marika Kaakinen</name><affiliation><nlm:aff id="A38">Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Institute of Health Sciences, University of Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Kettunen, Johannes" sort="Kettunen, Johannes" uniqKey="Kettunen J" first="Johannes" last="Kettunen">Johannes Kettunen</name><affiliation><nlm:aff id="A40">Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A41">Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E." last="Kleber">Marcus E. Kleber</name><affiliation><nlm:aff id="A42">Department of Internal Medicine II – Cardiology, University of Ulm Medical Centre, Ulm, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, Ludolf-Krehl-Strasse 7-11, 68167 Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Li, Xiaohui" sort="Li, Xiaohui" uniqKey="Li X" first="Xiaohui" last="Li">Xiaohui Li</name><affiliation><nlm:aff id="A44">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA</nlm:aff></affiliation></author><author><name sortKey="Luan, Jian An" sort="Luan, Jian An" uniqKey="Luan J" first="Jian'An" last="Luan">Jian'An Luan</name><affiliation><nlm:aff id="A45">MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name><affiliation><nlm:aff id="A46">Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A47">Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33014, Finland</nlm:aff></affiliation></author><author><name sortKey="Magnusson, Patrik K E" sort="Magnusson, Patrik K E" uniqKey="Magnusson P" first="Patrik K. E." last="Magnusson">Patrik K. E. Magnusson</name><affiliation><nlm:aff id="A13">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation><nlm:aff id="A48">Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Mihailov, Evelin" sort="Mihailov, Evelin" uniqKey="Mihailov E" first="Evelin" last="Mihailov">Evelin Mihailov</name><affiliation><nlm:aff id="A25">Estonian Genome Center of the University of Tartu, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Montasser, May E" sort="Montasser, May E" uniqKey="Montasser M" first="May E." last="Montasser">May E. Montasser</name><affiliation><nlm:aff id="A49">Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland</nlm:aff></affiliation></author><author><name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name><affiliation><nlm:aff id="A50">Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A51">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians University, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University of Munich, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M." last="Nolte">Ilja M. Nolte</name><affiliation><nlm:aff id="A53">Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="O Connell, Jeffrey R" sort="O Connell, Jeffrey R" uniqKey="O Connell J" first="Jeffrey R." last="O'Connell">Jeffrey R. O'Connell</name><affiliation><nlm:aff id="A49">Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland</nlm:aff></affiliation></author><author><name sortKey="Palmer, Cameron D" sort="Palmer, Cameron D" uniqKey="Palmer C" first="Cameron D." last="Palmer">Cameron D. Palmer</name><affiliation><nlm:aff id="A4">Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Division of Endocrinology, Children's Hospital Boston, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Division of Genetics, Program in Genomics, Children's Hospital Boston, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name><affiliation><nlm:aff id="A25">Estonian Genome Center of the University of Tartu, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A41">Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Petersen, Ann Kristin" sort="Petersen, Ann Kristin" uniqKey="Petersen A" first="Ann-Kristin" last="Petersen">Ann-Kristin Petersen</name><affiliation><nlm:aff id="A50">Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany</nlm:aff></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation><nlm:aff id="A56">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, 09042, Italy</nlm:aff></affiliation></author><author><name sortKey="Saxena, Richa" sort="Saxena, Richa" uniqKey="Saxena R" first="Richa" last="Saxena">Richa Saxena</name><affiliation><nlm:aff id="A2">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation></author><author><name sortKey="Service, Susan K" sort="Service, Susan K" uniqKey="Service S" first="Susan K." last="Service">Susan K. Service</name><affiliation><nlm:aff id="A57">Center for Neurobehavioral Genetics, The Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, USA</nlm:aff></affiliation></author><author><name sortKey="Shah, Sonia" sort="Shah, Sonia" uniqKey="Shah S" first="Sonia" last="Shah">Sonia Shah</name><affiliation><nlm:aff id="A58">Genetic Epidemiology Group, Deparment of Epidemiology and Public Health, UCL, London WC1E 6BT, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Shungin, Dmitry" sort="Shungin, Dmitry" uniqKey="Shungin D" first="Dmitry" last="Shungin">Dmitry Shungin</name><affiliation><nlm:aff id="A59">Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Scania University Hosptial, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A60">Department of Odontology, Umeå University, Umeå, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Department of Public Health and Primary Care, Unit of Medicine, Umeå University, Umeå, Sweden</nlm:aff></affiliation></author><author><name sortKey="Sidore, Carlo" sort="Sidore, Carlo" uniqKey="Sidore C" first="Carlo" last="Sidore">Carlo Sidore</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, 09042, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Dipartimento di Scienze Biomediche, Universita di Sassari, 07100 SS, Italy</nlm:aff></affiliation></author><author><name sortKey="Song, Ci" sort="Song, Ci" uniqKey="Song C" first="Ci" last="Song">Ci Song</name><affiliation><nlm:aff id="A10">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Science for Life Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Strawbridge, Rona J" sort="Strawbridge, Rona J" uniqKey="Strawbridge R" first="Rona J." last="Strawbridge">Rona J. Strawbridge</name><affiliation><nlm:aff id="A63">Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A64">Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Surakka, Ida" sort="Surakka, Ida" uniqKey="Surakka I" first="Ida" last="Surakka">Ida Surakka</name><affiliation><nlm:aff id="A40">Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A41">Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation><nlm:aff id="A65">Clinical Research Branch, National Institute Health, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Teslovich, Tanya M" sort="Teslovich, Tanya M" uniqKey="Teslovich T" first="Tanya M." last="Teslovich">Tanya M. Teslovich</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation><nlm:aff id="A66">deCODE Genetics/Amgen, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Van Den Herik, Evita G" sort="Van Den Herik, Evita G" uniqKey="Van Den Herik E" first="Evita G." last="Van Den Herik">Evita G. Van Den Herik</name><affiliation><nlm:aff id="A21">Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Voight, Benjamin F" sort="Voight, Benjamin F" uniqKey="Voight B" first="Benjamin F." last="Voight">Benjamin F. Voight</name><affiliation><nlm:aff id="A67">Department of Genetics, University of Pennsylvania - School of Medicine, Philadelphia PA, 19104, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania - School of Medicine, Philadelphia PA, 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Volcik, Kelly A" sort="Volcik, Kelly A" uniqKey="Volcik K" first="Kelly A." last="Volcik">Kelly A. Volcik</name><affiliation><nlm:aff id="A69">Human Genetics Center, University of Texas Health Science Center - School of Public Health, Houston, TX 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Waite, Lindsay L" sort="Waite, Lindsay L" uniqKey="Waite L" first="Lindsay L." last="Waite">Lindsay L. Waite</name><affiliation><nlm:aff id="A70">HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA</nlm:aff></affiliation></author><author><name sortKey="Wong, Andrew" sort="Wong, Andrew" uniqKey="Wong A" first="Andrew" last="Wong">Andrew Wong</name><affiliation><nlm:aff id="A71">MRC Unit for Lifelong Health and Ageing, 33 Bedford Place, London, WC1B 5JU, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Wu, Ying" sort="Wu, Ying" uniqKey="Wu Y" first="Ying" last="Wu">Ying Wu</name><affiliation><nlm:aff id="A14">Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 USA</nlm:aff></affiliation></author><author><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><affiliation><nlm:aff id="A72">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Ealing Hospital, Southall, Middlesex UB1 3HW, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Absher, Devin" sort="Absher, Devin" uniqKey="Absher D" first="Devin" last="Absher">Devin Absher</name><affiliation><nlm:aff id="A70">HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA</nlm:aff></affiliation></author><author><name sortKey="Asiki, Gershim" sort="Asiki, Gershim" uniqKey="Asiki G" first="Gershim" last="Asiki">Gershim Asiki</name><affiliation><nlm:aff id="A74">MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda</nlm:aff></affiliation></author><author><name sortKey="Barroso, Ines" sort="Barroso, Ines" uniqKey="Barroso I" first="Inês" last="Barroso">Inês Barroso</name><affiliation><nlm:aff id="A12">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A75">University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Level 4, Institute of Metabolic Science Box 289 Addenbrooke's Hospital Cambridge CB2 OQQ, UK</nlm:aff></affiliation></author><author><name sortKey="Been, Latonya F" sort="Been, Latonya F" uniqKey="Been L" first="Latonya F." last="Been">Latonya F. Been</name><affiliation><nlm:aff id="A76">Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Bolton, Jennifer L" sort="Bolton, Jennifer L" uniqKey="Bolton J" first="Jennifer L." last="Bolton">Jennifer L. Bolton</name><affiliation><nlm:aff id="A29">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Bonnycastle, Lori L" sort="Bonnycastle, Lori L" uniqKey="Bonnycastle L" first="Lori L" last="Bonnycastle">Lori L. Bonnycastle</name><affiliation><nlm:aff id="A77">Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Brambilla, Paolo" sort="Brambilla, Paolo" uniqKey="Brambilla P" first="Paolo" last="Brambilla">Paolo Brambilla</name><affiliation><nlm:aff id="A78">Department of Experimental Medicine, University of Milano Bicocca, Italy</nlm:aff></affiliation></author><author><name sortKey="Burnett, Mary S" sort="Burnett, Mary S" uniqKey="Burnett M" first="Mary S." last="Burnett">Mary S. Burnett</name><affiliation><nlm:aff id="A79">MedStar Health Research Institute, 6525 Belcrest Road, Suite 700, Hyattsville, MD 20782, USA</nlm:aff></affiliation></author><author><name sortKey="Cesana, Giancarlo" sort="Cesana, Giancarlo" uniqKey="Cesana G" first="Giancarlo" last="Cesana">Giancarlo Cesana</name><affiliation><nlm:aff id="A80">Research Centre on Public Health, University of Milano Bicocca, Italy</nlm:aff></affiliation></author><author><name sortKey="Dimitriou, Maria" sort="Dimitriou, Maria" uniqKey="Dimitriou M" first="Maria" last="Dimitriou">Maria Dimitriou</name><affiliation><nlm:aff id="A81">Department of Dietetics-Nutrition, Harokopio University, 70 El. Venizelou Str, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Doney, Alex S F" sort="Doney, Alex S F" uniqKey="Doney A" first="Alex S. F." last="Doney">Alex S. F. Doney</name><affiliation><nlm:aff id="A22">Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School. Dundee, DD1 9SY, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Doring, Angela" sort="Doring, Angela" uniqKey="Doring A" first="Angela" last="Döring">Angela Döring</name><affiliation><nlm:aff id="A82">Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg 85764, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A83">Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg 85764, Germany</nlm:aff></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation><nlm:aff id="A39">Institute of Health Sciences, University of Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A84">MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, UK</nlm:aff></affiliation></author><author><name sortKey="Epstein, Stephen E" sort="Epstein, Stephen E" uniqKey="Epstein S" first="Stephen E." last="Epstein">Stephen E. Epstein</name><affiliation><nlm:aff id="A79">MedStar Health Research Institute, 6525 Belcrest Road, Suite 700, Hyattsville, MD 20782, USA</nlm:aff></affiliation></author><author><name sortKey="Eyjolfsson, Gudmundur Ingi" sort="Eyjolfsson, Gudmundur Ingi" uniqKey="Eyjolfsson G" first="Gudmundur Ingi" last="Eyjolfsson">Gudmundur Ingi Eyjolfsson</name><affiliation><nlm:aff id="A85">The Laboratory in Mjodd, 108 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Gigante, Bruna" sort="Gigante, Bruna" uniqKey="Gigante B" first="Bruna" last="Gigante">Bruna Gigante</name><affiliation><nlm:aff id="A86">Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Goodarzi, Mark O" sort="Goodarzi, Mark O" uniqKey="Goodarzi M" first="Mark O." last="Goodarzi">Mark O. Goodarzi</name><affiliation><nlm:aff id="A87">Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA</nlm:aff></affiliation></author><author><name sortKey="Grallert, Harald" sort="Grallert, Harald" uniqKey="Grallert H" first="Harald" last="Grallert">Harald Grallert</name><affiliation><nlm:aff id="A88">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany</nlm:aff></affiliation></author><author><name sortKey="Gravito, Martha L" sort="Gravito, Martha L" uniqKey="Gravito M" first="Martha L." last="Gravito">Martha L. Gravito</name><affiliation><nlm:aff id="A76">Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Groves, Christopher J" sort="Groves, Christopher J" uniqKey="Groves C" first="Christopher J." last="Groves">Christopher J. Groves</name><affiliation><nlm:aff id="A89">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, OX3 7LJ, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Hallmans, Goran" sort="Hallmans, Goran" uniqKey="Hallmans G" first="Göran" last="Hallmans">Göran Hallmans</name><affiliation><nlm:aff id="A90">Department of Public Health and Clinical Medicine, Nutritional research, Umeå University, Umeå, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation><nlm:aff id="A91">Department of Clinical Sciences/Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="A92">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Hernandez, Dena" sort="Hernandez, Dena" uniqKey="Hernandez D" first="Dena" last="Hernandez">Dena Hernandez</name><affiliation><nlm:aff id="A93">Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A." last="Hicks">Andrew A. Hicks</name><affiliation><nlm:aff id="A94">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Holm, Hilma" sort="Holm, Hilma" uniqKey="Holm H" first="Hilma" last="Holm">Hilma Holm</name><affiliation><nlm:aff id="A66">deCODE Genetics/Amgen, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Hung, Yi Jen" sort="Hung, Yi Jen" uniqKey="Hung Y" first="Yi-Jen" last="Hung">Yi-Jen Hung</name><affiliation><nlm:aff id="A95">Division of Endocrinology & Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation><nlm:aff id="A88">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A96">Hannover Unified Biobank, Hannover Medical School, Hannover 30625, Germany</nlm:aff></affiliation></author><author><name sortKey="Jones, Michelle R" sort="Jones, Michelle R" uniqKey="Jones M" first="Michelle R." last="Jones">Michelle R. Jones</name><affiliation><nlm:aff id="A87">Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA</nlm:aff></affiliation></author><author><name sortKey="Kaleebu, Pontiano" sort="Kaleebu, Pontiano" uniqKey="Kaleebu P" first="Pontiano" last="Kaleebu">Pontiano Kaleebu</name><affiliation><nlm:aff id="A74">MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda</nlm:aff></affiliation></author><author><name sortKey="Kastelein, John J P" sort="Kastelein, John J P" uniqKey="Kastelein J" first="John J. P." last="Kastelein">John J. P. Kastelein</name><affiliation><nlm:aff id="A97">Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:aff id="A98">Clinical Gerontology Unit, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Kim, Eric" sort="Kim, Eric" uniqKey="Kim E" first="Eric" last="Kim">Eric Kim</name><affiliation><nlm:aff id="A44">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA</nlm:aff></affiliation></author><author><name sortKey="Klopp, Norman" sort="Klopp, Norman" uniqKey="Klopp N" first="Norman" last="Klopp">Norman Klopp</name><affiliation><nlm:aff id="A88">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A96">Hannover Unified Biobank, Hannover Medical School, Hannover 30625, Germany</nlm:aff></affiliation></author><author><name sortKey="Komulainen, Pirjo" sort="Komulainen, Pirjo" uniqKey="Komulainen P" first="Pirjo" last="Komulainen">Pirjo Komulainen</name><affiliation><nlm:aff id="A99">Kuopio Research Institute of Exercise Medicine, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name><affiliation><nlm:aff id="A58">Genetic Epidemiology Group, Deparment of Epidemiology and Public Health, UCL, London WC1E 6BT, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation><nlm:aff id="A45">MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:aff id="A46">Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A47">Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33014, Finland</nlm:aff></affiliation></author><author><name sortKey="Lin, Shih Yi" sort="Lin, Shih Yi" uniqKey="Lin S" first="Shih-Yi" last="Lin">Shih-Yi Lin</name><affiliation><nlm:aff id="A100">Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, School of Medicine, National Yang-Ming University, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Jaana" sort="Lindstrom, Jaana" uniqKey="Lindstrom J" first="Jaana" last="Lindström">Jaana Lindström</name><affiliation><nlm:aff id="A101">Diabetes Prevention Unit, National Institute for Health and Welfare, 00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J. F." last="Loos">Ruth J. F. Loos</name><affiliation><nlm:aff id="A45">MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A102">The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A103">The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A104">The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York</nlm:aff></affiliation></author><author><name sortKey="Mach, Francois" sort="Mach, Francois" uniqKey="Mach F" first="François" last="Mach">François Mach</name><affiliation><nlm:aff id="A23">Cardiology, Department of Specialities of Medicine, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L" last="Mcardle">Wendy L. Mcardle</name><affiliation><nlm:aff id="A105">School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Meisinger, Christa" sort="Meisinger, Christa" uniqKey="Meisinger C" first="Christa" last="Meisinger">Christa Meisinger</name><affiliation><nlm:aff id="A82">Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg 85764, Germany</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><affiliation><nlm:aff id="A49">Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland</nlm:aff></affiliation></author><author><name sortKey="Muller, Gabrielle" sort="Muller, Gabrielle" uniqKey="Muller G" first="Gabrielle" last="Müller">Gabrielle Müller</name><affiliation><nlm:aff id="A106">Institute for Medical Informatics and Biometrics, University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Nagaraja, Ramaiah" sort="Nagaraja, Ramaiah" uniqKey="Nagaraja R" first="Ramaiah" last="Nagaraja">Ramaiah Nagaraja</name><affiliation><nlm:aff id="A107">Laboratory of Genetics, National Institute on Aging, Baltimore, MD21224, USA</nlm:aff></affiliation></author><author><name sortKey="Narisu, Narisu" sort="Narisu, Narisu" uniqKey="Narisu N" first="Narisu" last="Narisu">Narisu Narisu</name><affiliation><nlm:aff id="A77">Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Nieminen, Tuomo V M" sort="Nieminen, Tuomo V M" uniqKey="Nieminen T" first="Tuomo V. M." last="Nieminen">Tuomo V. M. Nieminen</name><affiliation><nlm:aff id="A108">Department of Clinical Pharmacology, University of Tampere School of Medicine, Tampere 33014, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A109">Department of Internal Medicine, Päijät-Häme Central Hospital, Lahti, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A110">Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Nsubuga, Rebecca N" sort="Nsubuga, Rebecca N" uniqKey="Nsubuga R" first="Rebecca N." last="Nsubuga">Rebecca N. Nsubuga</name><affiliation><nlm:aff id="A74">MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda</nlm:aff></affiliation></author><author><name sortKey="Olafsson, Isleifur" sort="Olafsson, Isleifur" uniqKey="Olafsson I" first="Isleifur" last="Olafsson">Isleifur Olafsson</name><affiliation><nlm:aff id="A111">Department of Clinical Biochemistry, Landspitali University Hospital, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Ong, Ken K" sort="Ong, Ken K" uniqKey="Ong K" first="Ken K." last="Ong">Ken K. Ong</name><affiliation><nlm:aff id="A45">MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A71">MRC Unit for Lifelong Health and Ageing, 33 Bedford Place, London, WC1B 5JU, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation><nlm:aff id="A40">Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A112">Department of Medical Genetics, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A113">Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Papamarkou, Theodore" sort="Papamarkou, Theodore" uniqKey="Papamarkou T" first="Theodore" last="Papamarkou">Theodore Papamarkou</name><affiliation><nlm:aff id="A12">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A114">Department of Statistical Sciences, University College of London, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Pomilla, Cristina" sort="Pomilla, Cristina" uniqKey="Pomilla C" first="Cristina" last="Pomilla">Cristina Pomilla</name><affiliation><nlm:aff id="A12">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation><nlm:aff id="A91">Department of Clinical Sciences/Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A115">National Institute for Health and Welfare, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Rader, Daniel J" sort="Rader, Daniel J" uniqKey="Rader D" first="Daniel J." last="Rader">Daniel J. Rader</name><affiliation><nlm:aff id="A116">Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Building 421, Translational Research Center, Philadelphia, PA 19104-5158, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A117">Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Building 421, Translational Research Center, Philadelphia, PA 19104-5158, USA</nlm:aff></affiliation></author><author><name sortKey="Reilly, Muredach P" sort="Reilly, Muredach P" uniqKey="Reilly M" first="Muredach P." last="Reilly">Muredach P. Reilly</name><affiliation><nlm:aff id="A116">Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Building 421, Translational Research Center, Philadelphia, PA 19104-5158, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A117">Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Building 421, Translational Research Center, Philadelphia, PA 19104-5158, USA</nlm:aff></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name><affiliation><nlm:aff id="A15">Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave., Boston MA 02215, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Harvard Medical School, Boston MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="A118">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A119">Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A120">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="A29">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Ruokonen, Aimo" sort="Ruokonen, Aimo" uniqKey="Ruokonen A" first="Aimo" last="Ruokonen">Aimo Ruokonen</name><affiliation><nlm:aff id="A121">Department of Clinical Sciences/Clinical Chemistry, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Samani, Nilesh" sort="Samani, Nilesh" uniqKey="Samani N" first="Nilesh" last="Samani">Nilesh Samani</name><affiliation><nlm:aff id="A122">National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A123">Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, LE3 9QP, UK</nlm:aff></affiliation></author><author><name sortKey="Scharnagl, Hubert" sort="Scharnagl, Hubert" uniqKey="Scharnagl H" first="Hubert" last="Scharnagl">Hubert Scharnagl</name><affiliation><nlm:aff id="A124">Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Seeley, Janet" sort="Seeley, Janet" uniqKey="Seeley J" first="Janet" last="Seeley">Janet Seeley</name><affiliation><nlm:aff id="A74">MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda</nlm:aff></affiliation><affiliation><nlm:aff id="A125">School of International Development, University of East Anglia, Norwich NR4 7TJ, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Silander, Kaisa" sort="Silander, Kaisa" uniqKey="Silander K" first="Kaisa" last="Silander">Kaisa Silander</name><affiliation><nlm:aff id="A40">Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A41">Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Stan Kova, Alena" sort="Stan Kova, Alena" uniqKey="Stan Kova A" first="Alena" last="Stan Ková">Alena Stan Ková</name><affiliation><nlm:aff id="A126">University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Stirrups, Kathleen" sort="Stirrups, Kathleen" uniqKey="Stirrups K" first="Kathleen" last="Stirrups">Kathleen Stirrups</name><affiliation><nlm:aff id="A12">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Swift, Amy J" sort="Swift, Amy J" uniqKey="Swift A" first="Amy J." last="Swift">Amy J. Swift</name><affiliation><nlm:aff id="A77">Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Tiret, Laurence" sort="Tiret, Laurence" uniqKey="Tiret L" first="Laurence" last="Tiret">Laurence Tiret</name><affiliation><nlm:aff id="A127">INSERM UMRS 937, Pierre and Marie Curie University, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation><nlm:aff id="A118">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A119">Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A120">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Pelt, L Joost" sort="Van Pelt, L Joost" uniqKey="Van Pelt L" first="L. Joost" last="Van Pelt">L. Joost Van Pelt</name><affiliation><nlm:aff id="A128">Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A129">LifeLines Cohort Study, University of Groningen, University Medical Center Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Vedantam, Sailaja" sort="Vedantam, Sailaja" uniqKey="Vedantam S" first="Sailaja" last="Vedantam">Sailaja Vedantam</name><affiliation><nlm:aff id="A4">Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Division of Endocrinology, Children's Hospital Boston, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Division of Genetics, Program in Genomics, Children's Hospital Boston, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Wainwright, Nicholas" sort="Wainwright, Nicholas" uniqKey="Wainwright N" first="Nicholas" last="Wainwright">Nicholas Wainwright</name><affiliation><nlm:aff id="A12">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Wijmenga, Cisca" sort="Wijmenga, Cisca" uniqKey="Wijmenga C" first="Cisca" last="Wijmenga">Cisca Wijmenga</name><affiliation><nlm:aff id="A129">LifeLines Cohort Study, University of Groningen, University Medical Center Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A130">Department of Genetics, University of Groningen, University Medical Center Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name><affiliation><nlm:aff id="A29">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation><nlm:aff id="A131">Department of Biological Psychology, VU Univ, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wilsgaard, Tom" sort="Wilsgaard, Tom" uniqKey="Wilsgaard T" first="Tom" last="Wilsgaard">Tom Wilsgaard</name><affiliation><nlm:aff id="A132">Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway</nlm:aff></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="A29">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Young, Elizabeth H" sort="Young, Elizabeth H" uniqKey="Young E" first="Elizabeth H." last="Young">Elizabeth H. Young</name><affiliation><nlm:aff id="A12">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="A45">MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Adair, Linda S" sort="Adair, Linda S" uniqKey="Adair L" first="Linda S." last="Adair">Linda S. Adair</name><affiliation><nlm:aff id="A133">Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Arveiler, Dominique" sort="Arveiler, Dominique" uniqKey="Arveiler D" first="Dominique" last="Arveiler">Dominique Arveiler</name><affiliation><nlm:aff id="A134">Department of Epidemiology and Public Health, EA 3430, University of Strasbourg, Faculty of Medicine, Strasbourg, France</nlm:aff></affiliation></author><author><name sortKey="Assimes, Themistocles L" sort="Assimes, Themistocles L" uniqKey="Assimes T" first="Themistocles L." last="Assimes">Themistocles L. Assimes</name><affiliation><nlm:aff id="A135">Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name><affiliation><nlm:aff id="A136">Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Bennett, Franklyn" sort="Bennett, Franklyn" uniqKey="Bennett F" first="Franklyn" last="Bennett">Franklyn Bennett</name><affiliation><nlm:aff id="A137">Chemical Pathology, Department of Pathology, University of the West Indies, Mona, Kingston 7, Jamaica</nlm:aff></affiliation></author><author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name><affiliation><nlm:aff id="A138">Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Route de la Corniche 10, 1010 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Boehm, Bernhard O" sort="Boehm, Bernhard O" uniqKey="Boehm B" first="Bernhard O." last="Boehm">Bernhard O. Boehm</name><affiliation><nlm:aff id="A139">Division of Endocrinology and Diabetes, Department of Internal Medicine, Ulm University Medical Centre, Ulm, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A140">Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore</nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:aff id="A131">Department of Biological Psychology, VU Univ, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Borecki, Ingrid B" sort="Borecki, Ingrid B" uniqKey="Borecki I" first="Ingrid B." last="Borecki">Ingrid B. Borecki</name><affiliation><nlm:aff id="A27">Department of Genetics, Washington University School of Medicine, USA</nlm:aff></affiliation></author><author><name sortKey="Bornstein, Stefan R" sort="Bornstein, Stefan R" uniqKey="Bornstein S" first="Stefan R." last="Bornstein">Stefan R. Bornstein</name><affiliation><nlm:aff id="A141">Department of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Bovet, Pascal" sort="Bovet, Pascal" uniqKey="Bovet P" first="Pascal" last="Bovet">Pascal Bovet</name><affiliation><nlm:aff id="A138">Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Route de la Corniche 10, 1010 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A142">Ministry of Health, Victoria, Republic of Seychelles</nlm:aff></affiliation></author><author><name sortKey="Burnier, Michel" sort="Burnier, Michel" uniqKey="Burnier M" first="Michel" last="Burnier">Michel Burnier</name><affiliation><nlm:aff id="A143">Service of Nephrology, Lausanne University Hospital, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="A29">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Chakravarti, Aravinda" sort="Chakravarti, Aravinda" uniqKey="Chakravarti A" first="Aravinda" last="Chakravarti">Aravinda Chakravarti</name><affiliation><nlm:aff id="A24">Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA</nlm:aff></affiliation></author><author><name sortKey="Chambers, John C" sort="Chambers, John C" uniqKey="Chambers J" first="John C." last="Chambers">John C. Chambers</name><affiliation><nlm:aff id="A72">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Ealing Hospital, Southall, Middlesex UB1 3HW, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A144">Imperial College Healthcare NHS Trust, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Chen, Yii Der Ida" sort="Chen, Yii Der Ida" uniqKey="Chen Y" first="Yii-Der Ida" last="Chen">Yii-Der Ida Chen</name><affiliation><nlm:aff id="A145">Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A146">Department of Medicine, University of California Los Angeles, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Collins, Francis S" sort="Collins, Francis S" uniqKey="Collins F" first="Francis S." last="Collins">Francis S. Collins</name><affiliation><nlm:aff id="A77">Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Cooper, Richard S" sort="Cooper, Richard S" uniqKey="Cooper R" first="Richard S." last="Cooper">Richard S. Cooper</name><affiliation><nlm:aff id="A147">Department of Preventive Medicine and Epidemiology, Loyola University Medical School, Maywood, Illinois 60153, USA</nlm:aff></affiliation></author><author><name sortKey="Danesh, John" sort="Danesh, John" uniqKey="Danesh J" first="John" last="Danesh">John Danesh</name><affiliation><nlm:aff id="A30">Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Dedoussis, George" sort="Dedoussis, George" uniqKey="Dedoussis G" first="George" last="Dedoussis">George Dedoussis</name><affiliation><nlm:aff id="A81">Department of Dietetics-Nutrition, Harokopio University, 70 El. Venizelou Str, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="De Faire, Ulf" sort="De Faire, Ulf" uniqKey="De Faire U" first="Ulf" last="De Faire">Ulf De Faire</name><affiliation><nlm:aff id="A86">Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Feranil, Alan B" sort="Feranil, Alan B" uniqKey="Feranil A" first="Alan B." last="Feranil">Alan B. Feranil</name><affiliation><nlm:aff id="A148">Office of Population Studies Foundation, University of San Carlos, Talamban, Cebu City, Philippines</nlm:aff></affiliation></author><author><name sortKey="Ferrieres, Jean" sort="Ferrieres, Jean" uniqKey="Ferrieres J" first="Jean" last="Ferrières">Jean Ferrières</name><affiliation><nlm:aff id="A149">Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, France</nlm:aff></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation><nlm:aff id="A65">Clinical Research Branch, National Institute Health, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Freimer, Nelson B" sort="Freimer, Nelson B" uniqKey="Freimer N" first="Nelson B." last="Freimer">Nelson B. Freimer</name><affiliation><nlm:aff id="A57">Center for Neurobehavioral Genetics, The Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A150">Department of Psychiatry, University of California, Los Angeles, USA</nlm:aff></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation><nlm:aff id="A50">Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany</nlm:aff></affiliation></author><author><name sortKey="Groop, Leif C" sort="Groop, Leif C" uniqKey="Groop L" first="Leif C." last="Groop">Leif C. Groop</name><affiliation><nlm:aff id="A151">Department of Clinical Sciences, Lund University, SE-20502, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A152">Department of Medicine, Helsinki University Hospital, FI-00029 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="A153">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation><nlm:aff id="A34">Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name><affiliation><nlm:aff id="A63">Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A64">Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A154">Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="A155">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Ageing, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Hingorani, Aroon" sort="Hingorani, Aroon" uniqKey="Hingorani A" first="Aroon" last="Hingorani">Aroon Hingorani</name><affiliation><nlm:aff id="A58">Genetic Epidemiology Group, Deparment of Epidemiology and Public Health, UCL, London WC1E 6BT, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N." last="Hirschhorn">Joel N. Hirschhorn</name><affiliation><nlm:aff id="A4">Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Division of Endocrinology, Children's Hospital Boston, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Division of Genetics, Program in Genomics, Children's Hospital Boston, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A118">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A120">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hovingh, G Kees" sort="Hovingh, G Kees" uniqKey="Hovingh G" first="G. Kees" last="Hovingh">G. Kees Hovingh</name><affiliation><nlm:aff id="A97">Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hsiung, Chao Agnes" sort="Hsiung, Chao Agnes" uniqKey="Hsiung C" first="Chao Agnes" last="Hsiung">Chao Agnes Hsiung</name><affiliation><nlm:aff id="A156">Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Humphries, Steve E" sort="Humphries, Steve E" uniqKey="Humphries S" first="Steve E." last="Humphries">Steve E. Humphries</name><affiliation><nlm:aff id="A157">Cardiovascular Genetics, BHF Laboratories, Institute Cardiovascular Science, University College London, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Hunt, Steven C" sort="Hunt, Steven C" uniqKey="Hunt S" first="Steven C." last="Hunt">Steven C. Hunt</name><affiliation><nlm:aff id="A158">Cardiovascular Genetics, University of Utah School of Medicine, Salt Lake City, UT, USA</nlm:aff></affiliation></author><author><name sortKey="Hveem, Kristian" sort="Hveem, Kristian" uniqKey="Hveem K" first="Kristian" last="Hveem">Kristian Hveem</name><affiliation><nlm:aff id="A159">HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway</nlm:aff></affiliation></author><author><name sortKey="Iribarren, Carlos" sort="Iribarren, Carlos" uniqKey="Iribarren C" first="Carlos" last="Iribarren">Carlos Iribarren</name><affiliation><nlm:aff id="A160">Kaiser Permanente, Division of Research, Oakland, CA, USA</nlm:aff></affiliation></author><author><name sortKey="J Rvelin, Marjo Riitta" sort="J Rvelin, Marjo Riitta" uniqKey="J Rvelin M" first="Marjo-Riitta" last="J Rvelin">Marjo-Riitta J Rvelin</name><affiliation><nlm:aff id="A38">Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Institute of Health Sciences, University of Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A84">MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A115">National Institute for Health and Welfare, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A161">Unit of Primary Care, Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Jula, Antti" sort="Jula, Antti" uniqKey="Jula A" first="Antti" last="Jula">Antti Jula</name><affiliation><nlm:aff id="A162">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:aff id="A163">Department of Clinical Physiology, University of Tampere School of Medicine, Tampere 33014, Finland</nlm:aff></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation><nlm:aff id="A31">Hjelt Institute, Department of Public Health, University of Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A164">Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kes Niemi, Antero" sort="Kes Niemi, Antero" uniqKey="Kes Niemi A" first="Antero" last="Kes Niemi">Antero Kes Niemi</name><affiliation><nlm:aff id="A165">Institute of Clinical Medicine, Department of Medicine, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name><affiliation><nlm:aff id="A58">Genetic Epidemiology Group, Deparment of Epidemiology and Public Health, UCL, London WC1E 6BT, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S." last="Kooner">Jaspal S. Kooner</name><affiliation><nlm:aff id="A73">Ealing Hospital, Southall, Middlesex UB1 3HW, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A144">Imperial College Healthcare NHS Trust, London, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A166">National Heart & Lung Institute, Imperial College London, Hammersmith Hospital, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Koudstaal, Peter J" sort="Koudstaal, Peter J" uniqKey="Koudstaal P" first="Peter J." last="Koudstaal">Peter J. Koudstaal</name><affiliation><nlm:aff id="A21">Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Krauss, Ronald M" sort="Krauss, Ronald M" uniqKey="Krauss R" first="Ronald M." last="Krauss">Ronald M. Krauss</name><affiliation><nlm:aff id="A167">Children's Hospital Oakland Research Institute, 5700 Martin Luther King Junior Way, Oakland, CA 94609, USA</nlm:aff></affiliation></author><author><name sortKey="Kuh, Diana" sort="Kuh, Diana" uniqKey="Kuh D" first="Diana" last="Kuh">Diana Kuh</name><affiliation><nlm:aff id="A71">MRC Unit for Lifelong Health and Ageing, 33 Bedford Place, London, WC1B 5JU, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Kuusisto, Johanna" sort="Kuusisto, Johanna" uniqKey="Kuusisto J" first="Johanna" last="Kuusisto">Johanna Kuusisto</name><affiliation><nlm:aff id="A168">Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kyvik, Kirsten O" sort="Kyvik, Kirsten O" uniqKey="Kyvik K" first="Kirsten O." last="Kyvik">Kirsten O. Kyvik</name><affiliation><nlm:aff id="A169">Institute of Regional Health Services Research, University of Southern Denmark, Odense, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A170">Odense Patient data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Laakso, Markku" sort="Laakso, Markku" uniqKey="Laakso M" first="Markku" last="Laakso">Markku Laakso</name><affiliation><nlm:aff id="A168">Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Lakka, Timo A" sort="Lakka, Timo A" uniqKey="Lakka T" first="Timo A." last="Lakka">Timo A. Lakka</name><affiliation><nlm:aff id="A99">Kuopio Research Institute of Exercise Medicine, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A171">Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Finland</nlm:aff></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation><nlm:aff id="A172">Department of Medical Sciences, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lindgren, Cecilia M" sort="Lindgren, Cecilia M" uniqKey="Lindgren C" first="Cecilia M." last="Lindgren">Cecilia M. Lindgren</name><affiliation><nlm:aff id="A28">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="A173">Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Queensland 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="M Rz, Winfried" sort="M Rz, Winfried" uniqKey="M Rz W" first="Winfried" last="M Rz">Winfried M Rz</name><affiliation><nlm:aff id="A43">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, Ludolf-Krehl-Strasse 7-11, 68167 Mannheim, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A124">Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria</nlm:aff></affiliation><affiliation><nlm:aff id="A174">Synlab Academy, Synlab Services GmbH, Gottlieb-Daimler-Straβe 25, 68165 Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I." last="Mccarthy">Mark I. Mccarthy</name><affiliation><nlm:aff id="A28">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A89">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, OX3 7LJ, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Mckenzie, Colin A" sort="Mckenzie, Colin A" uniqKey="Mckenzie C" first="Colin A." last="Mckenzie">Colin A. Mckenzie</name><affiliation><nlm:aff id="A175">Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston 7, Jamaica</nlm:aff></affiliation></author><author><name sortKey="Meneton, Pierre" sort="Meneton, Pierre" uniqKey="Meneton P" first="Pierre" last="Meneton">Pierre Meneton</name><affiliation><nlm:aff id="A176">U872 Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, 75006 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation><nlm:aff id="A25">Estonian Genome Center of the University of Tartu, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Moilanen, Leena" sort="Moilanen, Leena" uniqKey="Moilanen L" first="Leena" last="Moilanen">Leena Moilanen</name><affiliation><nlm:aff id="A177">Department of Medicine, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Morris, Andrew D" sort="Morris, Andrew D" uniqKey="Morris A" first="Andrew D." last="Morris">Andrew D. Morris</name><affiliation><nlm:aff id="A22">Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School. Dundee, DD1 9SY, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Munroe, Patricia B" sort="Munroe, Patricia B" uniqKey="Munroe P" first="Patricia B." last="Munroe">Patricia B. Munroe</name><affiliation><nlm:aff id="A36">Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Clinical Pharmacology, NIHR Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Nj Lstad, Inger" sort="Nj Lstad, Inger" uniqKey="Nj Lstad I" first="Inger" last="Nj Lstad">Inger Nj Lstad</name><affiliation><nlm:aff id="A132">Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway</nlm:aff></affiliation></author><author><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L." last="Pedersen">Nancy L. Pedersen</name><affiliation><nlm:aff id="A13">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Power, Chris" sort="Power, Chris" uniqKey="Power C" first="Chris" last="Power">Chris Power</name><affiliation><nlm:aff id="A32">Centre For Paediatric Epidemiology and Biostatistics/MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><affiliation><nlm:aff id="A94">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A178">Department of Neurology, General Central Hospital, Bolzano, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A179">Department of Neurology, University of Lübeck, Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Price, Jackie F" sort="Price, Jackie F" uniqKey="Price J" first="Jackie F." last="Price">Jackie F. Price</name><affiliation><nlm:aff id="A29">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name><affiliation><nlm:aff id="A180">Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A181">Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Quertermous, Thomas" sort="Quertermous, Thomas" uniqKey="Quertermous T" first="Thomas" last="Quertermous">Thomas Quertermous</name><affiliation><nlm:aff id="A135">Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Rauramaa, Rainer" sort="Rauramaa, Rainer" uniqKey="Rauramaa R" first="Rainer" last="Rauramaa">Rainer Rauramaa</name><affiliation><nlm:aff id="A99">Kuopio Research Institute of Exercise Medicine, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A182">Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Saleheen, Danish" sort="Saleheen, Danish" uniqKey="Saleheen D" first="Danish" last="Saleheen">Danish Saleheen</name><affiliation><nlm:aff id="A30">Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A183">Center for Non-Communicable Diseases, Karachi, Pakistan</nlm:aff></affiliation><affiliation><nlm:aff id="A184">Department of Medicine, University of Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation><nlm:aff id="A185">Unit of Chronic Disease Epidemiology and Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Sanghera, Dharambir K" sort="Sanghera, Dharambir K" uniqKey="Sanghera D" first="Dharambir K." last="Sanghera">Dharambir K. Sanghera</name><affiliation><nlm:aff id="A76">Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Saramies, Jouko" sort="Saramies, Jouko" uniqKey="Saramies J" first="Jouko" last="Saramies">Jouko Saramies</name><affiliation><nlm:aff id="A186">South Karelia Central Hospital, Lappeenranta, Finland</nlm:aff></affiliation></author><author><name sortKey="Schwarz, Peter E H" sort="Schwarz, Peter E H" uniqKey="Schwarz P" first="Peter E. H." last="Schwarz">Peter E. H. Schwarz</name><affiliation><nlm:aff id="A141">Department of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A187">Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD), Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Sheu, Wayne H H" sort="Sheu, Wayne H H" uniqKey="Sheu W" first="Wayne H-H" last="Sheu">Wayne H-H Sheu</name><affiliation><nlm:aff id="A188">Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name><affiliation><nlm:aff id="A49">Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland</nlm:aff></affiliation><affiliation><nlm:aff id="A189">Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland</nlm:aff></affiliation></author><author><name sortKey="Siegbahn, Agneta" sort="Siegbahn, Agneta" uniqKey="Siegbahn A" first="Agneta" last="Siegbahn">Agneta Siegbahn</name><affiliation><nlm:aff id="A10">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A35">Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A172">Department of Medical Sciences, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><affiliation><nlm:aff id="A48">Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><nlm:aff id="A66">deCODE Genetics/Amgen, 101 Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A190">Faculty of Medicine, University of Iceland, 101 Reykjavík, Iceland</nlm:aff></affiliation></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P." last="Strachan">David P. Strachan</name><affiliation><nlm:aff id="A191">Division of Population Health Sciences and Education, St George's, University of London, Cranmer Terrace, London SW17 0RE, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Tayo, Bamidele O" sort="Tayo, Bamidele O" uniqKey="Tayo B" first="Bamidele O." last="Tayo">Bamidele O. Tayo</name><affiliation><nlm:aff id="A147">Department of Preventive Medicine and Epidemiology, Loyola University Medical School, Maywood, Illinois 60153, USA</nlm:aff></affiliation></author><author><name sortKey="Tremoli, Elena" sort="Tremoli, Elena" uniqKey="Tremoli E" first="Elena" last="Tremoli">Elena Tremoli</name><affiliation><nlm:aff id="A192">Department of Pharmacological Sciences, University of Milan, Monzino Cardiology Center, IRCCS, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Tuomilehto, Jaakko" sort="Tuomilehto, Jaakko" uniqKey="Tuomilehto J" first="Jaakko" last="Tuomilehto">Jaakko Tuomilehto</name><affiliation><nlm:aff id="A101">Diabetes Prevention Unit, National Institute for Health and Welfare, 00271 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A193">Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria</nlm:aff></affiliation><affiliation><nlm:aff id="A194">King Abdulaziz University, Faculty of Medicine, Jeddah 21589, Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="A195">Red RECAVA Grupo RD06/0014/0015, Hospital Universitario La Paz, 28046</nlm:aff></affiliation></author><author><name sortKey="Uusitupa, Matti" sort="Uusitupa, Matti" uniqKey="Uusitupa M" first="Matti" last="Uusitupa">Matti Uusitupa</name><affiliation><nlm:aff id="A196">Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A197">Research Unit, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Centre for Medical Systems Biology, Leiden, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:aff id="A198">Department of Medicine, Lausanne University Hospital, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Wallentin, Lars" sort="Wallentin, Lars" uniqKey="Wallentin L" first="Lars" last="Wallentin">Lars Wallentin</name><affiliation><nlm:aff id="A35">Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A172">Department of Medical Sciences, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A45">MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B." last="Whitfield">John B. Whitfield</name><affiliation><nlm:aff id="A173">Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Queensland 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Wolffenbuttel, Bruce H R" sort="Wolffenbuttel, Bruce H R" uniqKey="Wolffenbuttel B" first="Bruce H. R." last="Wolffenbuttel">Bruce H. R. Wolffenbuttel</name><affiliation><nlm:aff id="A129">LifeLines Cohort Study, University of Groningen, University Medical Center Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A199">Department of Endocrinology, University of Groningen, University Medical Center Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Altshuler, David" sort="Altshuler, David" uniqKey="Altshuler D" first="David" last="Altshuler">David Altshuler</name><affiliation><nlm:aff id="A2">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA</nlm:aff></affiliation></author><author><name sortKey="Ordovas, Jose M" sort="Ordovas, Jose M" uniqKey="Ordovas J" first="Jose M." last="Ordovas">Jose M. Ordovas</name><affiliation><nlm:aff id="A200">Department of Cardiovascular Epidemiology and Population Genetics, National Center for Cardiovascular Investigation, Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A201">IMDEA-Alimentacion, Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A202">Nutrition and Genomics Laboratory, Jean Mayer-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation><nlm:aff id="A69">Human Genetics Center, University of Texas Health Science Center - School of Public Health, Houston, TX 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Palmer, Colin N A" sort="Palmer, Colin N A" uniqKey="Palmer C" first="Colin N. A." last="Palmer">Colin N. A. Palmer</name><affiliation><nlm:aff id="A22">Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School. Dundee, DD1 9SY, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation><nlm:aff id="A66">deCODE Genetics/Amgen, 101 Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A190">Faculty of Medicine, University of Iceland, 101 Reykjavík, Iceland</nlm:aff></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name><affiliation><nlm:aff id="A15">Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave., Boston MA 02215, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Harvard Medical School, Boston MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name><affiliation><nlm:aff id="A44">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA</nlm:aff></affiliation></author><author><name sortKey="Franks, Paul W" sort="Franks, Paul W" uniqKey="Franks P" first="Paul W." last="Franks">Paul W. Franks</name><affiliation><nlm:aff id="A59">Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Scania University Hosptial, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Department of Public Health and Primary Care, Unit of Medicine, Umeå University, Umeå, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A203">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Ripatti, Samuli" sort="Ripatti, Samuli" uniqKey="Ripatti S" first="Samuli" last="Ripatti">Samuli Ripatti</name><affiliation><nlm:aff id="A12">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A41">Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Cupples, L Adrienne" sort="Cupples, L Adrienne" uniqKey="Cupples L" first="L. Adrienne" last="Cupples">L. Adrienne Cupples</name><affiliation><nlm:aff id="A9">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A204">Framingham Heart Study, Framingham, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Sandhu, Manjinder S" sort="Sandhu, Manjinder S" uniqKey="Sandhu M" first="Manjinder S." last="Sandhu">Manjinder S. Sandhu</name><affiliation><nlm:aff id="A12">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Rich, Stephen S" sort="Rich, Stephen S" uniqKey="Rich S" first="Stephen S." last="Rich">Stephen S. Rich</name><affiliation><nlm:aff id="A205">Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA</nlm:aff></affiliation></author><author><name sortKey="Boehnke, Michael" sort="Boehnke, Michael" uniqKey="Boehnke M" first="Michael" last="Boehnke">Michael Boehnke</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name><affiliation><nlm:aff id="A12">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Mohlke, Karen L" sort="Mohlke, Karen L" uniqKey="Mohlke K" first="Karen L." last="Mohlke">Karen L. Mohlke</name><affiliation><nlm:aff id="A14">Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 USA</nlm:aff></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation><nlm:aff id="A10">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Science for Life Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Abecasis, Goncalo R" sort="Abecasis, Goncalo R" uniqKey="Abecasis G" first="Goncalo R." last="Abecasis">Goncalo R. Abecasis</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Daly, Mark J" sort="Daly, Mark J" uniqKey="Daly M" first="Mark J." last="Daly">Mark J. Daly</name><affiliation><nlm:aff id="A2">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A206">Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02138, USA</nlm:aff></affiliation></author><author><name sortKey="Neale, Benjamin M" sort="Neale, Benjamin M" uniqKey="Neale B" first="Benjamin M." last="Neale">Benjamin M. Neale</name><affiliation><nlm:aff id="A2">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A206">Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02138, USA</nlm:aff></affiliation></author><author><name sortKey="Kathiresan, Sekar" sort="Kathiresan, Sekar" uniqKey="Kathiresan S" first="Sekar" last="Kathiresan">Sekar Kathiresan</name><affiliation><nlm:aff id="A1">Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24097064</idno><idno type="pmc">3904346</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904346</idno><idno type="RBID">PMC:3904346</idno><idno type="doi">10.1038/ng.2795</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">002E30</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E30</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Common variants associated with plasma triglycerides and risk for coronary artery disease</title><author><name sortKey="Do, Ron" sort="Do, Ron" uniqKey="Do R" first="Ron" last="Do">Ron Do</name><affiliation><nlm:aff id="A1">Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA</nlm:aff></affiliation></author><author><name sortKey="Willer, Cristen J" sort="Willer, Cristen J" uniqKey="Willer C" first="Cristen J." last="Willer">Cristen J. Willer</name><affiliation><nlm:aff id="A5">Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Ellen M" sort="Schmidt, Ellen M" uniqKey="Schmidt E" first="Ellen M." last="Schmidt">Ellen M. Schmidt</name><affiliation><nlm:aff id="A6">Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Sengupta, Sebanti" sort="Sengupta, Sebanti" uniqKey="Sengupta S" first="Sebanti" last="Sengupta">Sebanti Sengupta</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Gao, Chi" sort="Gao, Chi" uniqKey="Gao C" first="Chi" last="Gao">Chi Gao</name><affiliation><nlm:aff id="A1">Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA</nlm:aff></affiliation></author><author><name sortKey="Peloso, Gina M" sort="Peloso, Gina M" uniqKey="Peloso G" first="Gina M." last="Peloso">Gina M. Peloso</name><affiliation><nlm:aff id="A2">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Gustafsson, Stefan" sort="Gustafsson, Stefan" uniqKey="Gustafsson S" first="Stefan" last="Gustafsson">Stefan Gustafsson</name><affiliation><nlm:aff id="A10">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Science for Life Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kanoni, Stavroula" sort="Kanoni, Stavroula" uniqKey="Kanoni S" first="Stavroula" last="Kanoni">Stavroula Kanoni</name><affiliation><nlm:aff id="A12">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Ganna, Andrea" sort="Ganna, Andrea" uniqKey="Ganna A" first="Andrea" last="Ganna">Andrea Ganna</name><affiliation><nlm:aff id="A10">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Science for Life Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Chen, Jin" sort="Chen, Jin" uniqKey="Chen J" first="Jin" last="Chen">Jin Chen</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Buchkovich, Martin L" sort="Buchkovich, Martin L" uniqKey="Buchkovich M" first="Martin L." last="Buchkovich">Martin L. Buchkovich</name><affiliation><nlm:aff id="A14">Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 USA</nlm:aff></affiliation></author><author><name sortKey="Mora, Samia" sort="Mora, Samia" uniqKey="Mora S" first="Samia" last="Mora">Samia Mora</name><affiliation><nlm:aff id="A15">Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave., Boston MA 02215, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Harvard Medical School, Boston MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Jacques S" sort="Beckmann, Jacques S" uniqKey="Beckmann J" first="Jacques S." last="Beckmann">Jacques S. Beckmann</name><affiliation><nlm:aff id="A17">Service of Medical Genetics, Lausanne University Hospital, Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Bragg Gresham, Jennifer L" sort="Bragg Gresham, Jennifer L" uniqKey="Bragg Gresham J" first="Jennifer L." last="Bragg-Gresham">Jennifer L. Bragg-Gresham</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Chang, Hsing Yi" sort="Chang, Hsing Yi" uniqKey="Chang H" first="Hsing-Yi" last="Chang">Hsing-Yi Chang</name><affiliation><nlm:aff id="A19">Division of Preventive Medicine and Health Services Research, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Demirkan, Ay E" sort="Demirkan, Ay E" uniqKey="Demirkan A" first="Ay E" last="Demirkan">Ay E Demirkan</name><affiliation><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Den Hertog, Heleen M" sort="Den Hertog, Heleen M" uniqKey="Den Hertog H" first="Heleen M." last="Den Hertog">Heleen M. Den Hertog</name><affiliation><nlm:aff id="A21">Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Donnelly, Louise A" sort="Donnelly, Louise A" uniqKey="Donnelly L" first="Louise A." last="Donnelly">Louise A. Donnelly</name><affiliation><nlm:aff id="A22">Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School. Dundee, DD1 9SY, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Ehret, Georg B" sort="Ehret, Georg B" uniqKey="Ehret G" first="Georg B." last="Ehret">Georg B. Ehret</name><affiliation><nlm:aff id="A23">Cardiology, Department of Specialities of Medicine, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA</nlm:aff></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation><nlm:aff id="A4">Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A25">Estonian Genome Center of the University of Tartu, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Feitosa, Mary F" sort="Feitosa, Mary F" uniqKey="Feitosa M" first="Mary F." last="Feitosa">Mary F. Feitosa</name><affiliation><nlm:aff id="A27">Department of Genetics, Washington University School of Medicine, USA</nlm:aff></affiliation></author><author><name sortKey="Ferreira, Teresa" sort="Ferreira, Teresa" uniqKey="Ferreira T" first="Teresa" last="Ferreira">Teresa Ferreira</name><affiliation><nlm:aff id="A28">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name><affiliation><nlm:aff id="A25">Estonian Genome Center of the University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Fontanillas, Pierre" sort="Fontanillas, Pierre" uniqKey="Fontanillas P" first="Pierre" last="Fontanillas">Pierre Fontanillas</name><affiliation><nlm:aff id="A4">Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA</nlm:aff></affiliation></author><author><name sortKey="Fraser, Ross M" sort="Fraser, Ross M" uniqKey="Fraser R" first="Ross M." last="Fraser">Ross M. Fraser</name><affiliation><nlm:aff id="A29">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Freitag, Daniel F" sort="Freitag, Daniel F" uniqKey="Freitag D" first="Daniel F." last="Freitag">Daniel F. Freitag</name><affiliation><nlm:aff id="A30">Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Gurdasani, Deepti" sort="Gurdasani, Deepti" uniqKey="Gurdasani D" first="Deepti" last="Gurdasani">Deepti Gurdasani</name><affiliation><nlm:aff id="A12">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Heikkil, Kauko" sort="Heikkil, Kauko" uniqKey="Heikkil K" first="Kauko" last="Heikkil">Kauko Heikkil</name><affiliation><nlm:aff id="A31">Hjelt Institute, Department of Public Health, University of Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><affiliation><nlm:aff id="A32">Centre For Paediatric Epidemiology and Biostatistics/MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name><affiliation><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Centre for Medical Systems Biology, Leiden, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Jackson, Anne U" sort="Jackson, Anne U" uniqKey="Jackson A" first="Anne U." last="Jackson">Anne U. Jackson</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation><nlm:aff id="A34">Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A35">Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name><affiliation><nlm:aff id="A36">Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Clinical Pharmacology, NIHR Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kaakinen, Marika" sort="Kaakinen, Marika" uniqKey="Kaakinen M" first="Marika" last="Kaakinen">Marika Kaakinen</name><affiliation><nlm:aff id="A38">Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Institute of Health Sciences, University of Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Kettunen, Johannes" sort="Kettunen, Johannes" uniqKey="Kettunen J" first="Johannes" last="Kettunen">Johannes Kettunen</name><affiliation><nlm:aff id="A40">Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A41">Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E." last="Kleber">Marcus E. Kleber</name><affiliation><nlm:aff id="A42">Department of Internal Medicine II – Cardiology, University of Ulm Medical Centre, Ulm, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, Ludolf-Krehl-Strasse 7-11, 68167 Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Li, Xiaohui" sort="Li, Xiaohui" uniqKey="Li X" first="Xiaohui" last="Li">Xiaohui Li</name><affiliation><nlm:aff id="A44">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA</nlm:aff></affiliation></author><author><name sortKey="Luan, Jian An" sort="Luan, Jian An" uniqKey="Luan J" first="Jian'An" last="Luan">Jian'An Luan</name><affiliation><nlm:aff id="A45">MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name><affiliation><nlm:aff id="A46">Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A47">Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33014, Finland</nlm:aff></affiliation></author><author><name sortKey="Magnusson, Patrik K E" sort="Magnusson, Patrik K E" uniqKey="Magnusson P" first="Patrik K. E." last="Magnusson">Patrik K. E. Magnusson</name><affiliation><nlm:aff id="A13">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation><nlm:aff id="A48">Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Mihailov, Evelin" sort="Mihailov, Evelin" uniqKey="Mihailov E" first="Evelin" last="Mihailov">Evelin Mihailov</name><affiliation><nlm:aff id="A25">Estonian Genome Center of the University of Tartu, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Montasser, May E" sort="Montasser, May E" uniqKey="Montasser M" first="May E." last="Montasser">May E. Montasser</name><affiliation><nlm:aff id="A49">Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland</nlm:aff></affiliation></author><author><name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name><affiliation><nlm:aff id="A50">Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A51">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians University, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University of Munich, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M." last="Nolte">Ilja M. Nolte</name><affiliation><nlm:aff id="A53">Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="O Connell, Jeffrey R" sort="O Connell, Jeffrey R" uniqKey="O Connell J" first="Jeffrey R." last="O'Connell">Jeffrey R. O'Connell</name><affiliation><nlm:aff id="A49">Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland</nlm:aff></affiliation></author><author><name sortKey="Palmer, Cameron D" sort="Palmer, Cameron D" uniqKey="Palmer C" first="Cameron D." last="Palmer">Cameron D. Palmer</name><affiliation><nlm:aff id="A4">Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Division of Endocrinology, Children's Hospital Boston, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Division of Genetics, Program in Genomics, Children's Hospital Boston, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name><affiliation><nlm:aff id="A25">Estonian Genome Center of the University of Tartu, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A41">Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Petersen, Ann Kristin" sort="Petersen, Ann Kristin" uniqKey="Petersen A" first="Ann-Kristin" last="Petersen">Ann-Kristin Petersen</name><affiliation><nlm:aff id="A50">Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany</nlm:aff></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation><nlm:aff id="A56">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, 09042, Italy</nlm:aff></affiliation></author><author><name sortKey="Saxena, Richa" sort="Saxena, Richa" uniqKey="Saxena R" first="Richa" last="Saxena">Richa Saxena</name><affiliation><nlm:aff id="A2">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation></author><author><name sortKey="Service, Susan K" sort="Service, Susan K" uniqKey="Service S" first="Susan K." last="Service">Susan K. Service</name><affiliation><nlm:aff id="A57">Center for Neurobehavioral Genetics, The Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, USA</nlm:aff></affiliation></author><author><name sortKey="Shah, Sonia" sort="Shah, Sonia" uniqKey="Shah S" first="Sonia" last="Shah">Sonia Shah</name><affiliation><nlm:aff id="A58">Genetic Epidemiology Group, Deparment of Epidemiology and Public Health, UCL, London WC1E 6BT, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Shungin, Dmitry" sort="Shungin, Dmitry" uniqKey="Shungin D" first="Dmitry" last="Shungin">Dmitry Shungin</name><affiliation><nlm:aff id="A59">Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Scania University Hosptial, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A60">Department of Odontology, Umeå University, Umeå, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Department of Public Health and Primary Care, Unit of Medicine, Umeå University, Umeå, Sweden</nlm:aff></affiliation></author><author><name sortKey="Sidore, Carlo" sort="Sidore, Carlo" uniqKey="Sidore C" first="Carlo" last="Sidore">Carlo Sidore</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, 09042, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Dipartimento di Scienze Biomediche, Universita di Sassari, 07100 SS, Italy</nlm:aff></affiliation></author><author><name sortKey="Song, Ci" sort="Song, Ci" uniqKey="Song C" first="Ci" last="Song">Ci Song</name><affiliation><nlm:aff id="A10">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Science for Life Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Strawbridge, Rona J" sort="Strawbridge, Rona J" uniqKey="Strawbridge R" first="Rona J." last="Strawbridge">Rona J. Strawbridge</name><affiliation><nlm:aff id="A63">Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A64">Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Surakka, Ida" sort="Surakka, Ida" uniqKey="Surakka I" first="Ida" last="Surakka">Ida Surakka</name><affiliation><nlm:aff id="A40">Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A41">Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation><nlm:aff id="A65">Clinical Research Branch, National Institute Health, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Teslovich, Tanya M" sort="Teslovich, Tanya M" uniqKey="Teslovich T" first="Tanya M." last="Teslovich">Tanya M. Teslovich</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation><nlm:aff id="A66">deCODE Genetics/Amgen, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Van Den Herik, Evita G" sort="Van Den Herik, Evita G" uniqKey="Van Den Herik E" first="Evita G." last="Van Den Herik">Evita G. Van Den Herik</name><affiliation><nlm:aff id="A21">Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Voight, Benjamin F" sort="Voight, Benjamin F" uniqKey="Voight B" first="Benjamin F." last="Voight">Benjamin F. Voight</name><affiliation><nlm:aff id="A67">Department of Genetics, University of Pennsylvania - School of Medicine, Philadelphia PA, 19104, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania - School of Medicine, Philadelphia PA, 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Volcik, Kelly A" sort="Volcik, Kelly A" uniqKey="Volcik K" first="Kelly A." last="Volcik">Kelly A. Volcik</name><affiliation><nlm:aff id="A69">Human Genetics Center, University of Texas Health Science Center - School of Public Health, Houston, TX 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Waite, Lindsay L" sort="Waite, Lindsay L" uniqKey="Waite L" first="Lindsay L." last="Waite">Lindsay L. Waite</name><affiliation><nlm:aff id="A70">HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA</nlm:aff></affiliation></author><author><name sortKey="Wong, Andrew" sort="Wong, Andrew" uniqKey="Wong A" first="Andrew" last="Wong">Andrew Wong</name><affiliation><nlm:aff id="A71">MRC Unit for Lifelong Health and Ageing, 33 Bedford Place, London, WC1B 5JU, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Wu, Ying" sort="Wu, Ying" uniqKey="Wu Y" first="Ying" last="Wu">Ying Wu</name><affiliation><nlm:aff id="A14">Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 USA</nlm:aff></affiliation></author><author><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><affiliation><nlm:aff id="A72">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Ealing Hospital, Southall, Middlesex UB1 3HW, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Absher, Devin" sort="Absher, Devin" uniqKey="Absher D" first="Devin" last="Absher">Devin Absher</name><affiliation><nlm:aff id="A70">HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA</nlm:aff></affiliation></author><author><name sortKey="Asiki, Gershim" sort="Asiki, Gershim" uniqKey="Asiki G" first="Gershim" last="Asiki">Gershim Asiki</name><affiliation><nlm:aff id="A74">MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda</nlm:aff></affiliation></author><author><name sortKey="Barroso, Ines" sort="Barroso, Ines" uniqKey="Barroso I" first="Inês" last="Barroso">Inês Barroso</name><affiliation><nlm:aff id="A12">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A75">University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Level 4, Institute of Metabolic Science Box 289 Addenbrooke's Hospital Cambridge CB2 OQQ, UK</nlm:aff></affiliation></author><author><name sortKey="Been, Latonya F" sort="Been, Latonya F" uniqKey="Been L" first="Latonya F." last="Been">Latonya F. Been</name><affiliation><nlm:aff id="A76">Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Bolton, Jennifer L" sort="Bolton, Jennifer L" uniqKey="Bolton J" first="Jennifer L." last="Bolton">Jennifer L. Bolton</name><affiliation><nlm:aff id="A29">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Bonnycastle, Lori L" sort="Bonnycastle, Lori L" uniqKey="Bonnycastle L" first="Lori L" last="Bonnycastle">Lori L. Bonnycastle</name><affiliation><nlm:aff id="A77">Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Brambilla, Paolo" sort="Brambilla, Paolo" uniqKey="Brambilla P" first="Paolo" last="Brambilla">Paolo Brambilla</name><affiliation><nlm:aff id="A78">Department of Experimental Medicine, University of Milano Bicocca, Italy</nlm:aff></affiliation></author><author><name sortKey="Burnett, Mary S" sort="Burnett, Mary S" uniqKey="Burnett M" first="Mary S." last="Burnett">Mary S. Burnett</name><affiliation><nlm:aff id="A79">MedStar Health Research Institute, 6525 Belcrest Road, Suite 700, Hyattsville, MD 20782, USA</nlm:aff></affiliation></author><author><name sortKey="Cesana, Giancarlo" sort="Cesana, Giancarlo" uniqKey="Cesana G" first="Giancarlo" last="Cesana">Giancarlo Cesana</name><affiliation><nlm:aff id="A80">Research Centre on Public Health, University of Milano Bicocca, Italy</nlm:aff></affiliation></author><author><name sortKey="Dimitriou, Maria" sort="Dimitriou, Maria" uniqKey="Dimitriou M" first="Maria" last="Dimitriou">Maria Dimitriou</name><affiliation><nlm:aff id="A81">Department of Dietetics-Nutrition, Harokopio University, 70 El. Venizelou Str, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Doney, Alex S F" sort="Doney, Alex S F" uniqKey="Doney A" first="Alex S. F." last="Doney">Alex S. F. Doney</name><affiliation><nlm:aff id="A22">Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School. Dundee, DD1 9SY, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Doring, Angela" sort="Doring, Angela" uniqKey="Doring A" first="Angela" last="Döring">Angela Döring</name><affiliation><nlm:aff id="A82">Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg 85764, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A83">Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg 85764, Germany</nlm:aff></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation><nlm:aff id="A39">Institute of Health Sciences, University of Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A84">MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, UK</nlm:aff></affiliation></author><author><name sortKey="Epstein, Stephen E" sort="Epstein, Stephen E" uniqKey="Epstein S" first="Stephen E." last="Epstein">Stephen E. Epstein</name><affiliation><nlm:aff id="A79">MedStar Health Research Institute, 6525 Belcrest Road, Suite 700, Hyattsville, MD 20782, USA</nlm:aff></affiliation></author><author><name sortKey="Eyjolfsson, Gudmundur Ingi" sort="Eyjolfsson, Gudmundur Ingi" uniqKey="Eyjolfsson G" first="Gudmundur Ingi" last="Eyjolfsson">Gudmundur Ingi Eyjolfsson</name><affiliation><nlm:aff id="A85">The Laboratory in Mjodd, 108 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Gigante, Bruna" sort="Gigante, Bruna" uniqKey="Gigante B" first="Bruna" last="Gigante">Bruna Gigante</name><affiliation><nlm:aff id="A86">Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Goodarzi, Mark O" sort="Goodarzi, Mark O" uniqKey="Goodarzi M" first="Mark O." last="Goodarzi">Mark O. Goodarzi</name><affiliation><nlm:aff id="A87">Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA</nlm:aff></affiliation></author><author><name sortKey="Grallert, Harald" sort="Grallert, Harald" uniqKey="Grallert H" first="Harald" last="Grallert">Harald Grallert</name><affiliation><nlm:aff id="A88">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany</nlm:aff></affiliation></author><author><name sortKey="Gravito, Martha L" sort="Gravito, Martha L" uniqKey="Gravito M" first="Martha L." last="Gravito">Martha L. Gravito</name><affiliation><nlm:aff id="A76">Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Groves, Christopher J" sort="Groves, Christopher J" uniqKey="Groves C" first="Christopher J." last="Groves">Christopher J. Groves</name><affiliation><nlm:aff id="A89">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, OX3 7LJ, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Hallmans, Goran" sort="Hallmans, Goran" uniqKey="Hallmans G" first="Göran" last="Hallmans">Göran Hallmans</name><affiliation><nlm:aff id="A90">Department of Public Health and Clinical Medicine, Nutritional research, Umeå University, Umeå, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation><nlm:aff id="A91">Department of Clinical Sciences/Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="A92">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Hernandez, Dena" sort="Hernandez, Dena" uniqKey="Hernandez D" first="Dena" last="Hernandez">Dena Hernandez</name><affiliation><nlm:aff id="A93">Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A." last="Hicks">Andrew A. Hicks</name><affiliation><nlm:aff id="A94">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Holm, Hilma" sort="Holm, Hilma" uniqKey="Holm H" first="Hilma" last="Holm">Hilma Holm</name><affiliation><nlm:aff id="A66">deCODE Genetics/Amgen, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Hung, Yi Jen" sort="Hung, Yi Jen" uniqKey="Hung Y" first="Yi-Jen" last="Hung">Yi-Jen Hung</name><affiliation><nlm:aff id="A95">Division of Endocrinology & Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation><nlm:aff id="A88">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A96">Hannover Unified Biobank, Hannover Medical School, Hannover 30625, Germany</nlm:aff></affiliation></author><author><name sortKey="Jones, Michelle R" sort="Jones, Michelle R" uniqKey="Jones M" first="Michelle R." last="Jones">Michelle R. Jones</name><affiliation><nlm:aff id="A87">Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA</nlm:aff></affiliation></author><author><name sortKey="Kaleebu, Pontiano" sort="Kaleebu, Pontiano" uniqKey="Kaleebu P" first="Pontiano" last="Kaleebu">Pontiano Kaleebu</name><affiliation><nlm:aff id="A74">MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda</nlm:aff></affiliation></author><author><name sortKey="Kastelein, John J P" sort="Kastelein, John J P" uniqKey="Kastelein J" first="John J. P." last="Kastelein">John J. P. Kastelein</name><affiliation><nlm:aff id="A97">Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:aff id="A98">Clinical Gerontology Unit, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Kim, Eric" sort="Kim, Eric" uniqKey="Kim E" first="Eric" last="Kim">Eric Kim</name><affiliation><nlm:aff id="A44">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA</nlm:aff></affiliation></author><author><name sortKey="Klopp, Norman" sort="Klopp, Norman" uniqKey="Klopp N" first="Norman" last="Klopp">Norman Klopp</name><affiliation><nlm:aff id="A88">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A96">Hannover Unified Biobank, Hannover Medical School, Hannover 30625, Germany</nlm:aff></affiliation></author><author><name sortKey="Komulainen, Pirjo" sort="Komulainen, Pirjo" uniqKey="Komulainen P" first="Pirjo" last="Komulainen">Pirjo Komulainen</name><affiliation><nlm:aff id="A99">Kuopio Research Institute of Exercise Medicine, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name><affiliation><nlm:aff id="A58">Genetic Epidemiology Group, Deparment of Epidemiology and Public Health, UCL, London WC1E 6BT, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation><nlm:aff id="A45">MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:aff id="A46">Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A47">Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33014, Finland</nlm:aff></affiliation></author><author><name sortKey="Lin, Shih Yi" sort="Lin, Shih Yi" uniqKey="Lin S" first="Shih-Yi" last="Lin">Shih-Yi Lin</name><affiliation><nlm:aff id="A100">Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, School of Medicine, National Yang-Ming University, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Jaana" sort="Lindstrom, Jaana" uniqKey="Lindstrom J" first="Jaana" last="Lindström">Jaana Lindström</name><affiliation><nlm:aff id="A101">Diabetes Prevention Unit, National Institute for Health and Welfare, 00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J. F." last="Loos">Ruth J. F. Loos</name><affiliation><nlm:aff id="A45">MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A102">The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A103">The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A104">The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York</nlm:aff></affiliation></author><author><name sortKey="Mach, Francois" sort="Mach, Francois" uniqKey="Mach F" first="François" last="Mach">François Mach</name><affiliation><nlm:aff id="A23">Cardiology, Department of Specialities of Medicine, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L" last="Mcardle">Wendy L. Mcardle</name><affiliation><nlm:aff id="A105">School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Meisinger, Christa" sort="Meisinger, Christa" uniqKey="Meisinger C" first="Christa" last="Meisinger">Christa Meisinger</name><affiliation><nlm:aff id="A82">Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg 85764, Germany</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><affiliation><nlm:aff id="A49">Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland</nlm:aff></affiliation></author><author><name sortKey="Muller, Gabrielle" sort="Muller, Gabrielle" uniqKey="Muller G" first="Gabrielle" last="Müller">Gabrielle Müller</name><affiliation><nlm:aff id="A106">Institute for Medical Informatics and Biometrics, University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Nagaraja, Ramaiah" sort="Nagaraja, Ramaiah" uniqKey="Nagaraja R" first="Ramaiah" last="Nagaraja">Ramaiah Nagaraja</name><affiliation><nlm:aff id="A107">Laboratory of Genetics, National Institute on Aging, Baltimore, MD21224, USA</nlm:aff></affiliation></author><author><name sortKey="Narisu, Narisu" sort="Narisu, Narisu" uniqKey="Narisu N" first="Narisu" last="Narisu">Narisu Narisu</name><affiliation><nlm:aff id="A77">Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Nieminen, Tuomo V M" sort="Nieminen, Tuomo V M" uniqKey="Nieminen T" first="Tuomo V. M." last="Nieminen">Tuomo V. M. Nieminen</name><affiliation><nlm:aff id="A108">Department of Clinical Pharmacology, University of Tampere School of Medicine, Tampere 33014, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A109">Department of Internal Medicine, Päijät-Häme Central Hospital, Lahti, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A110">Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Nsubuga, Rebecca N" sort="Nsubuga, Rebecca N" uniqKey="Nsubuga R" first="Rebecca N." last="Nsubuga">Rebecca N. Nsubuga</name><affiliation><nlm:aff id="A74">MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda</nlm:aff></affiliation></author><author><name sortKey="Olafsson, Isleifur" sort="Olafsson, Isleifur" uniqKey="Olafsson I" first="Isleifur" last="Olafsson">Isleifur Olafsson</name><affiliation><nlm:aff id="A111">Department of Clinical Biochemistry, Landspitali University Hospital, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Ong, Ken K" sort="Ong, Ken K" uniqKey="Ong K" first="Ken K." last="Ong">Ken K. Ong</name><affiliation><nlm:aff id="A45">MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A71">MRC Unit for Lifelong Health and Ageing, 33 Bedford Place, London, WC1B 5JU, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation><nlm:aff id="A40">Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A112">Department of Medical Genetics, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A113">Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Papamarkou, Theodore" sort="Papamarkou, Theodore" uniqKey="Papamarkou T" first="Theodore" last="Papamarkou">Theodore Papamarkou</name><affiliation><nlm:aff id="A12">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A114">Department of Statistical Sciences, University College of London, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Pomilla, Cristina" sort="Pomilla, Cristina" uniqKey="Pomilla C" first="Cristina" last="Pomilla">Cristina Pomilla</name><affiliation><nlm:aff id="A12">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation><nlm:aff id="A91">Department of Clinical Sciences/Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A115">National Institute for Health and Welfare, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Rader, Daniel J" sort="Rader, Daniel J" uniqKey="Rader D" first="Daniel J." last="Rader">Daniel J. Rader</name><affiliation><nlm:aff id="A116">Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Building 421, Translational Research Center, Philadelphia, PA 19104-5158, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A117">Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Building 421, Translational Research Center, Philadelphia, PA 19104-5158, USA</nlm:aff></affiliation></author><author><name sortKey="Reilly, Muredach P" sort="Reilly, Muredach P" uniqKey="Reilly M" first="Muredach P." last="Reilly">Muredach P. Reilly</name><affiliation><nlm:aff id="A116">Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Building 421, Translational Research Center, Philadelphia, PA 19104-5158, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A117">Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Building 421, Translational Research Center, Philadelphia, PA 19104-5158, USA</nlm:aff></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name><affiliation><nlm:aff id="A15">Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave., Boston MA 02215, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Harvard Medical School, Boston MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="A118">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A119">Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A120">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="A29">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Ruokonen, Aimo" sort="Ruokonen, Aimo" uniqKey="Ruokonen A" first="Aimo" last="Ruokonen">Aimo Ruokonen</name><affiliation><nlm:aff id="A121">Department of Clinical Sciences/Clinical Chemistry, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Samani, Nilesh" sort="Samani, Nilesh" uniqKey="Samani N" first="Nilesh" last="Samani">Nilesh Samani</name><affiliation><nlm:aff id="A122">National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A123">Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, LE3 9QP, UK</nlm:aff></affiliation></author><author><name sortKey="Scharnagl, Hubert" sort="Scharnagl, Hubert" uniqKey="Scharnagl H" first="Hubert" last="Scharnagl">Hubert Scharnagl</name><affiliation><nlm:aff id="A124">Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Seeley, Janet" sort="Seeley, Janet" uniqKey="Seeley J" first="Janet" last="Seeley">Janet Seeley</name><affiliation><nlm:aff id="A74">MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda</nlm:aff></affiliation><affiliation><nlm:aff id="A125">School of International Development, University of East Anglia, Norwich NR4 7TJ, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Silander, Kaisa" sort="Silander, Kaisa" uniqKey="Silander K" first="Kaisa" last="Silander">Kaisa Silander</name><affiliation><nlm:aff id="A40">Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A41">Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Stan Kova, Alena" sort="Stan Kova, Alena" uniqKey="Stan Kova A" first="Alena" last="Stan Ková">Alena Stan Ková</name><affiliation><nlm:aff id="A126">University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Stirrups, Kathleen" sort="Stirrups, Kathleen" uniqKey="Stirrups K" first="Kathleen" last="Stirrups">Kathleen Stirrups</name><affiliation><nlm:aff id="A12">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Swift, Amy J" sort="Swift, Amy J" uniqKey="Swift A" first="Amy J." last="Swift">Amy J. Swift</name><affiliation><nlm:aff id="A77">Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Tiret, Laurence" sort="Tiret, Laurence" uniqKey="Tiret L" first="Laurence" last="Tiret">Laurence Tiret</name><affiliation><nlm:aff id="A127">INSERM UMRS 937, Pierre and Marie Curie University, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation><nlm:aff id="A118">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A119">Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A120">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Pelt, L Joost" sort="Van Pelt, L Joost" uniqKey="Van Pelt L" first="L. Joost" last="Van Pelt">L. Joost Van Pelt</name><affiliation><nlm:aff id="A128">Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A129">LifeLines Cohort Study, University of Groningen, University Medical Center Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Vedantam, Sailaja" sort="Vedantam, Sailaja" uniqKey="Vedantam S" first="Sailaja" last="Vedantam">Sailaja Vedantam</name><affiliation><nlm:aff id="A4">Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Division of Endocrinology, Children's Hospital Boston, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Division of Genetics, Program in Genomics, Children's Hospital Boston, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Wainwright, Nicholas" sort="Wainwright, Nicholas" uniqKey="Wainwright N" first="Nicholas" last="Wainwright">Nicholas Wainwright</name><affiliation><nlm:aff id="A12">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Wijmenga, Cisca" sort="Wijmenga, Cisca" uniqKey="Wijmenga C" first="Cisca" last="Wijmenga">Cisca Wijmenga</name><affiliation><nlm:aff id="A129">LifeLines Cohort Study, University of Groningen, University Medical Center Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A130">Department of Genetics, University of Groningen, University Medical Center Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name><affiliation><nlm:aff id="A29">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation><nlm:aff id="A131">Department of Biological Psychology, VU Univ, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wilsgaard, Tom" sort="Wilsgaard, Tom" uniqKey="Wilsgaard T" first="Tom" last="Wilsgaard">Tom Wilsgaard</name><affiliation><nlm:aff id="A132">Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway</nlm:aff></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="A29">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Young, Elizabeth H" sort="Young, Elizabeth H" uniqKey="Young E" first="Elizabeth H." last="Young">Elizabeth H. Young</name><affiliation><nlm:aff id="A12">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="A45">MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Adair, Linda S" sort="Adair, Linda S" uniqKey="Adair L" first="Linda S." last="Adair">Linda S. Adair</name><affiliation><nlm:aff id="A133">Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Arveiler, Dominique" sort="Arveiler, Dominique" uniqKey="Arveiler D" first="Dominique" last="Arveiler">Dominique Arveiler</name><affiliation><nlm:aff id="A134">Department of Epidemiology and Public Health, EA 3430, University of Strasbourg, Faculty of Medicine, Strasbourg, France</nlm:aff></affiliation></author><author><name sortKey="Assimes, Themistocles L" sort="Assimes, Themistocles L" uniqKey="Assimes T" first="Themistocles L." last="Assimes">Themistocles L. Assimes</name><affiliation><nlm:aff id="A135">Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name><affiliation><nlm:aff id="A136">Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Bennett, Franklyn" sort="Bennett, Franklyn" uniqKey="Bennett F" first="Franklyn" last="Bennett">Franklyn Bennett</name><affiliation><nlm:aff id="A137">Chemical Pathology, Department of Pathology, University of the West Indies, Mona, Kingston 7, Jamaica</nlm:aff></affiliation></author><author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name><affiliation><nlm:aff id="A138">Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Route de la Corniche 10, 1010 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Boehm, Bernhard O" sort="Boehm, Bernhard O" uniqKey="Boehm B" first="Bernhard O." last="Boehm">Bernhard O. Boehm</name><affiliation><nlm:aff id="A139">Division of Endocrinology and Diabetes, Department of Internal Medicine, Ulm University Medical Centre, Ulm, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A140">Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore</nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:aff id="A131">Department of Biological Psychology, VU Univ, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Borecki, Ingrid B" sort="Borecki, Ingrid B" uniqKey="Borecki I" first="Ingrid B." last="Borecki">Ingrid B. Borecki</name><affiliation><nlm:aff id="A27">Department of Genetics, Washington University School of Medicine, USA</nlm:aff></affiliation></author><author><name sortKey="Bornstein, Stefan R" sort="Bornstein, Stefan R" uniqKey="Bornstein S" first="Stefan R." last="Bornstein">Stefan R. Bornstein</name><affiliation><nlm:aff id="A141">Department of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Bovet, Pascal" sort="Bovet, Pascal" uniqKey="Bovet P" first="Pascal" last="Bovet">Pascal Bovet</name><affiliation><nlm:aff id="A138">Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Route de la Corniche 10, 1010 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A142">Ministry of Health, Victoria, Republic of Seychelles</nlm:aff></affiliation></author><author><name sortKey="Burnier, Michel" sort="Burnier, Michel" uniqKey="Burnier M" first="Michel" last="Burnier">Michel Burnier</name><affiliation><nlm:aff id="A143">Service of Nephrology, Lausanne University Hospital, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="A29">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Chakravarti, Aravinda" sort="Chakravarti, Aravinda" uniqKey="Chakravarti A" first="Aravinda" last="Chakravarti">Aravinda Chakravarti</name><affiliation><nlm:aff id="A24">Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA</nlm:aff></affiliation></author><author><name sortKey="Chambers, John C" sort="Chambers, John C" uniqKey="Chambers J" first="John C." last="Chambers">John C. Chambers</name><affiliation><nlm:aff id="A72">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Ealing Hospital, Southall, Middlesex UB1 3HW, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A144">Imperial College Healthcare NHS Trust, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Chen, Yii Der Ida" sort="Chen, Yii Der Ida" uniqKey="Chen Y" first="Yii-Der Ida" last="Chen">Yii-Der Ida Chen</name><affiliation><nlm:aff id="A145">Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A146">Department of Medicine, University of California Los Angeles, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Collins, Francis S" sort="Collins, Francis S" uniqKey="Collins F" first="Francis S." last="Collins">Francis S. Collins</name><affiliation><nlm:aff id="A77">Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Cooper, Richard S" sort="Cooper, Richard S" uniqKey="Cooper R" first="Richard S." last="Cooper">Richard S. Cooper</name><affiliation><nlm:aff id="A147">Department of Preventive Medicine and Epidemiology, Loyola University Medical School, Maywood, Illinois 60153, USA</nlm:aff></affiliation></author><author><name sortKey="Danesh, John" sort="Danesh, John" uniqKey="Danesh J" first="John" last="Danesh">John Danesh</name><affiliation><nlm:aff id="A30">Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Dedoussis, George" sort="Dedoussis, George" uniqKey="Dedoussis G" first="George" last="Dedoussis">George Dedoussis</name><affiliation><nlm:aff id="A81">Department of Dietetics-Nutrition, Harokopio University, 70 El. Venizelou Str, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="De Faire, Ulf" sort="De Faire, Ulf" uniqKey="De Faire U" first="Ulf" last="De Faire">Ulf De Faire</name><affiliation><nlm:aff id="A86">Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Feranil, Alan B" sort="Feranil, Alan B" uniqKey="Feranil A" first="Alan B." last="Feranil">Alan B. Feranil</name><affiliation><nlm:aff id="A148">Office of Population Studies Foundation, University of San Carlos, Talamban, Cebu City, Philippines</nlm:aff></affiliation></author><author><name sortKey="Ferrieres, Jean" sort="Ferrieres, Jean" uniqKey="Ferrieres J" first="Jean" last="Ferrières">Jean Ferrières</name><affiliation><nlm:aff id="A149">Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, France</nlm:aff></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation><nlm:aff id="A65">Clinical Research Branch, National Institute Health, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Freimer, Nelson B" sort="Freimer, Nelson B" uniqKey="Freimer N" first="Nelson B." last="Freimer">Nelson B. Freimer</name><affiliation><nlm:aff id="A57">Center for Neurobehavioral Genetics, The Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A150">Department of Psychiatry, University of California, Los Angeles, USA</nlm:aff></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation><nlm:aff id="A50">Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany</nlm:aff></affiliation></author><author><name sortKey="Groop, Leif C" sort="Groop, Leif C" uniqKey="Groop L" first="Leif C." last="Groop">Leif C. Groop</name><affiliation><nlm:aff id="A151">Department of Clinical Sciences, Lund University, SE-20502, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A152">Department of Medicine, Helsinki University Hospital, FI-00029 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="A153">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation><nlm:aff id="A34">Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name><affiliation><nlm:aff id="A63">Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A64">Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A154">Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="A155">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Ageing, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Hingorani, Aroon" sort="Hingorani, Aroon" uniqKey="Hingorani A" first="Aroon" last="Hingorani">Aroon Hingorani</name><affiliation><nlm:aff id="A58">Genetic Epidemiology Group, Deparment of Epidemiology and Public Health, UCL, London WC1E 6BT, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N." last="Hirschhorn">Joel N. Hirschhorn</name><affiliation><nlm:aff id="A4">Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Division of Endocrinology, Children's Hospital Boston, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Division of Genetics, Program in Genomics, Children's Hospital Boston, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A118">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A120">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hovingh, G Kees" sort="Hovingh, G Kees" uniqKey="Hovingh G" first="G. Kees" last="Hovingh">G. Kees Hovingh</name><affiliation><nlm:aff id="A97">Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hsiung, Chao Agnes" sort="Hsiung, Chao Agnes" uniqKey="Hsiung C" first="Chao Agnes" last="Hsiung">Chao Agnes Hsiung</name><affiliation><nlm:aff id="A156">Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Humphries, Steve E" sort="Humphries, Steve E" uniqKey="Humphries S" first="Steve E." last="Humphries">Steve E. Humphries</name><affiliation><nlm:aff id="A157">Cardiovascular Genetics, BHF Laboratories, Institute Cardiovascular Science, University College London, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Hunt, Steven C" sort="Hunt, Steven C" uniqKey="Hunt S" first="Steven C." last="Hunt">Steven C. Hunt</name><affiliation><nlm:aff id="A158">Cardiovascular Genetics, University of Utah School of Medicine, Salt Lake City, UT, USA</nlm:aff></affiliation></author><author><name sortKey="Hveem, Kristian" sort="Hveem, Kristian" uniqKey="Hveem K" first="Kristian" last="Hveem">Kristian Hveem</name><affiliation><nlm:aff id="A159">HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway</nlm:aff></affiliation></author><author><name sortKey="Iribarren, Carlos" sort="Iribarren, Carlos" uniqKey="Iribarren C" first="Carlos" last="Iribarren">Carlos Iribarren</name><affiliation><nlm:aff id="A160">Kaiser Permanente, Division of Research, Oakland, CA, USA</nlm:aff></affiliation></author><author><name sortKey="J Rvelin, Marjo Riitta" sort="J Rvelin, Marjo Riitta" uniqKey="J Rvelin M" first="Marjo-Riitta" last="J Rvelin">Marjo-Riitta J Rvelin</name><affiliation><nlm:aff id="A38">Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Institute of Health Sciences, University of Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A84">MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A115">National Institute for Health and Welfare, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A161">Unit of Primary Care, Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Jula, Antti" sort="Jula, Antti" uniqKey="Jula A" first="Antti" last="Jula">Antti Jula</name><affiliation><nlm:aff id="A162">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:aff id="A163">Department of Clinical Physiology, University of Tampere School of Medicine, Tampere 33014, Finland</nlm:aff></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation><nlm:aff id="A31">Hjelt Institute, Department of Public Health, University of Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A164">Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kes Niemi, Antero" sort="Kes Niemi, Antero" uniqKey="Kes Niemi A" first="Antero" last="Kes Niemi">Antero Kes Niemi</name><affiliation><nlm:aff id="A165">Institute of Clinical Medicine, Department of Medicine, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name><affiliation><nlm:aff id="A58">Genetic Epidemiology Group, Deparment of Epidemiology and Public Health, UCL, London WC1E 6BT, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S." last="Kooner">Jaspal S. Kooner</name><affiliation><nlm:aff id="A73">Ealing Hospital, Southall, Middlesex UB1 3HW, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A144">Imperial College Healthcare NHS Trust, London, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A166">National Heart & Lung Institute, Imperial College London, Hammersmith Hospital, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Koudstaal, Peter J" sort="Koudstaal, Peter J" uniqKey="Koudstaal P" first="Peter J." last="Koudstaal">Peter J. Koudstaal</name><affiliation><nlm:aff id="A21">Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Krauss, Ronald M" sort="Krauss, Ronald M" uniqKey="Krauss R" first="Ronald M." last="Krauss">Ronald M. Krauss</name><affiliation><nlm:aff id="A167">Children's Hospital Oakland Research Institute, 5700 Martin Luther King Junior Way, Oakland, CA 94609, USA</nlm:aff></affiliation></author><author><name sortKey="Kuh, Diana" sort="Kuh, Diana" uniqKey="Kuh D" first="Diana" last="Kuh">Diana Kuh</name><affiliation><nlm:aff id="A71">MRC Unit for Lifelong Health and Ageing, 33 Bedford Place, London, WC1B 5JU, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Kuusisto, Johanna" sort="Kuusisto, Johanna" uniqKey="Kuusisto J" first="Johanna" last="Kuusisto">Johanna Kuusisto</name><affiliation><nlm:aff id="A168">Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kyvik, Kirsten O" sort="Kyvik, Kirsten O" uniqKey="Kyvik K" first="Kirsten O." last="Kyvik">Kirsten O. Kyvik</name><affiliation><nlm:aff id="A169">Institute of Regional Health Services Research, University of Southern Denmark, Odense, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A170">Odense Patient data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Laakso, Markku" sort="Laakso, Markku" uniqKey="Laakso M" first="Markku" last="Laakso">Markku Laakso</name><affiliation><nlm:aff id="A168">Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Lakka, Timo A" sort="Lakka, Timo A" uniqKey="Lakka T" first="Timo A." last="Lakka">Timo A. Lakka</name><affiliation><nlm:aff id="A99">Kuopio Research Institute of Exercise Medicine, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A171">Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Finland</nlm:aff></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation><nlm:aff id="A172">Department of Medical Sciences, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lindgren, Cecilia M" sort="Lindgren, Cecilia M" uniqKey="Lindgren C" first="Cecilia M." last="Lindgren">Cecilia M. Lindgren</name><affiliation><nlm:aff id="A28">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="A173">Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Queensland 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="M Rz, Winfried" sort="M Rz, Winfried" uniqKey="M Rz W" first="Winfried" last="M Rz">Winfried M Rz</name><affiliation><nlm:aff id="A43">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, Ludolf-Krehl-Strasse 7-11, 68167 Mannheim, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A124">Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria</nlm:aff></affiliation><affiliation><nlm:aff id="A174">Synlab Academy, Synlab Services GmbH, Gottlieb-Daimler-Straβe 25, 68165 Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I." last="Mccarthy">Mark I. Mccarthy</name><affiliation><nlm:aff id="A28">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A89">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, OX3 7LJ, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Mckenzie, Colin A" sort="Mckenzie, Colin A" uniqKey="Mckenzie C" first="Colin A." last="Mckenzie">Colin A. Mckenzie</name><affiliation><nlm:aff id="A175">Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston 7, Jamaica</nlm:aff></affiliation></author><author><name sortKey="Meneton, Pierre" sort="Meneton, Pierre" uniqKey="Meneton P" first="Pierre" last="Meneton">Pierre Meneton</name><affiliation><nlm:aff id="A176">U872 Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, 75006 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation><nlm:aff id="A25">Estonian Genome Center of the University of Tartu, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Moilanen, Leena" sort="Moilanen, Leena" uniqKey="Moilanen L" first="Leena" last="Moilanen">Leena Moilanen</name><affiliation><nlm:aff id="A177">Department of Medicine, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Morris, Andrew D" sort="Morris, Andrew D" uniqKey="Morris A" first="Andrew D." last="Morris">Andrew D. Morris</name><affiliation><nlm:aff id="A22">Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School. Dundee, DD1 9SY, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Munroe, Patricia B" sort="Munroe, Patricia B" uniqKey="Munroe P" first="Patricia B." last="Munroe">Patricia B. Munroe</name><affiliation><nlm:aff id="A36">Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Clinical Pharmacology, NIHR Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Nj Lstad, Inger" sort="Nj Lstad, Inger" uniqKey="Nj Lstad I" first="Inger" last="Nj Lstad">Inger Nj Lstad</name><affiliation><nlm:aff id="A132">Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway</nlm:aff></affiliation></author><author><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L." last="Pedersen">Nancy L. Pedersen</name><affiliation><nlm:aff id="A13">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Power, Chris" sort="Power, Chris" uniqKey="Power C" first="Chris" last="Power">Chris Power</name><affiliation><nlm:aff id="A32">Centre For Paediatric Epidemiology and Biostatistics/MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><affiliation><nlm:aff id="A94">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A178">Department of Neurology, General Central Hospital, Bolzano, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A179">Department of Neurology, University of Lübeck, Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Price, Jackie F" sort="Price, Jackie F" uniqKey="Price J" first="Jackie F." last="Price">Jackie F. Price</name><affiliation><nlm:aff id="A29">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name><affiliation><nlm:aff id="A180">Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A181">Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Quertermous, Thomas" sort="Quertermous, Thomas" uniqKey="Quertermous T" first="Thomas" last="Quertermous">Thomas Quertermous</name><affiliation><nlm:aff id="A135">Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Rauramaa, Rainer" sort="Rauramaa, Rainer" uniqKey="Rauramaa R" first="Rainer" last="Rauramaa">Rainer Rauramaa</name><affiliation><nlm:aff id="A99">Kuopio Research Institute of Exercise Medicine, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A182">Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Saleheen, Danish" sort="Saleheen, Danish" uniqKey="Saleheen D" first="Danish" last="Saleheen">Danish Saleheen</name><affiliation><nlm:aff id="A30">Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A183">Center for Non-Communicable Diseases, Karachi, Pakistan</nlm:aff></affiliation><affiliation><nlm:aff id="A184">Department of Medicine, University of Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation><nlm:aff id="A185">Unit of Chronic Disease Epidemiology and Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Sanghera, Dharambir K" sort="Sanghera, Dharambir K" uniqKey="Sanghera D" first="Dharambir K." last="Sanghera">Dharambir K. Sanghera</name><affiliation><nlm:aff id="A76">Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Saramies, Jouko" sort="Saramies, Jouko" uniqKey="Saramies J" first="Jouko" last="Saramies">Jouko Saramies</name><affiliation><nlm:aff id="A186">South Karelia Central Hospital, Lappeenranta, Finland</nlm:aff></affiliation></author><author><name sortKey="Schwarz, Peter E H" sort="Schwarz, Peter E H" uniqKey="Schwarz P" first="Peter E. H." last="Schwarz">Peter E. H. Schwarz</name><affiliation><nlm:aff id="A141">Department of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A187">Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD), Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Sheu, Wayne H H" sort="Sheu, Wayne H H" uniqKey="Sheu W" first="Wayne H-H" last="Sheu">Wayne H-H Sheu</name><affiliation><nlm:aff id="A188">Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name><affiliation><nlm:aff id="A49">Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland</nlm:aff></affiliation><affiliation><nlm:aff id="A189">Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland</nlm:aff></affiliation></author><author><name sortKey="Siegbahn, Agneta" sort="Siegbahn, Agneta" uniqKey="Siegbahn A" first="Agneta" last="Siegbahn">Agneta Siegbahn</name><affiliation><nlm:aff id="A10">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A35">Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A172">Department of Medical Sciences, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><affiliation><nlm:aff id="A48">Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><nlm:aff id="A66">deCODE Genetics/Amgen, 101 Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A190">Faculty of Medicine, University of Iceland, 101 Reykjavík, Iceland</nlm:aff></affiliation></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P." last="Strachan">David P. Strachan</name><affiliation><nlm:aff id="A191">Division of Population Health Sciences and Education, St George's, University of London, Cranmer Terrace, London SW17 0RE, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Tayo, Bamidele O" sort="Tayo, Bamidele O" uniqKey="Tayo B" first="Bamidele O." last="Tayo">Bamidele O. Tayo</name><affiliation><nlm:aff id="A147">Department of Preventive Medicine and Epidemiology, Loyola University Medical School, Maywood, Illinois 60153, USA</nlm:aff></affiliation></author><author><name sortKey="Tremoli, Elena" sort="Tremoli, Elena" uniqKey="Tremoli E" first="Elena" last="Tremoli">Elena Tremoli</name><affiliation><nlm:aff id="A192">Department of Pharmacological Sciences, University of Milan, Monzino Cardiology Center, IRCCS, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Tuomilehto, Jaakko" sort="Tuomilehto, Jaakko" uniqKey="Tuomilehto J" first="Jaakko" last="Tuomilehto">Jaakko Tuomilehto</name><affiliation><nlm:aff id="A101">Diabetes Prevention Unit, National Institute for Health and Welfare, 00271 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A193">Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria</nlm:aff></affiliation><affiliation><nlm:aff id="A194">King Abdulaziz University, Faculty of Medicine, Jeddah 21589, Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="A195">Red RECAVA Grupo RD06/0014/0015, Hospital Universitario La Paz, 28046</nlm:aff></affiliation></author><author><name sortKey="Uusitupa, Matti" sort="Uusitupa, Matti" uniqKey="Uusitupa M" first="Matti" last="Uusitupa">Matti Uusitupa</name><affiliation><nlm:aff id="A196">Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A197">Research Unit, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Centre for Medical Systems Biology, Leiden, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:aff id="A198">Department of Medicine, Lausanne University Hospital, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Wallentin, Lars" sort="Wallentin, Lars" uniqKey="Wallentin L" first="Lars" last="Wallentin">Lars Wallentin</name><affiliation><nlm:aff id="A35">Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A172">Department of Medical Sciences, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A45">MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B." last="Whitfield">John B. Whitfield</name><affiliation><nlm:aff id="A173">Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Queensland 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Wolffenbuttel, Bruce H R" sort="Wolffenbuttel, Bruce H R" uniqKey="Wolffenbuttel B" first="Bruce H. R." last="Wolffenbuttel">Bruce H. R. Wolffenbuttel</name><affiliation><nlm:aff id="A129">LifeLines Cohort Study, University of Groningen, University Medical Center Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A199">Department of Endocrinology, University of Groningen, University Medical Center Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Altshuler, David" sort="Altshuler, David" uniqKey="Altshuler D" first="David" last="Altshuler">David Altshuler</name><affiliation><nlm:aff id="A2">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA</nlm:aff></affiliation></author><author><name sortKey="Ordovas, Jose M" sort="Ordovas, Jose M" uniqKey="Ordovas J" first="Jose M." last="Ordovas">Jose M. Ordovas</name><affiliation><nlm:aff id="A200">Department of Cardiovascular Epidemiology and Population Genetics, National Center for Cardiovascular Investigation, Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A201">IMDEA-Alimentacion, Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A202">Nutrition and Genomics Laboratory, Jean Mayer-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation><nlm:aff id="A69">Human Genetics Center, University of Texas Health Science Center - School of Public Health, Houston, TX 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Palmer, Colin N A" sort="Palmer, Colin N A" uniqKey="Palmer C" first="Colin N. A." last="Palmer">Colin N. A. Palmer</name><affiliation><nlm:aff id="A22">Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School. Dundee, DD1 9SY, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation><nlm:aff id="A66">deCODE Genetics/Amgen, 101 Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A190">Faculty of Medicine, University of Iceland, 101 Reykjavík, Iceland</nlm:aff></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name><affiliation><nlm:aff id="A15">Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave., Boston MA 02215, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Harvard Medical School, Boston MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name><affiliation><nlm:aff id="A44">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA</nlm:aff></affiliation></author><author><name sortKey="Franks, Paul W" sort="Franks, Paul W" uniqKey="Franks P" first="Paul W." last="Franks">Paul W. Franks</name><affiliation><nlm:aff id="A59">Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Scania University Hosptial, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Department of Public Health and Primary Care, Unit of Medicine, Umeå University, Umeå, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A203">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Ripatti, Samuli" sort="Ripatti, Samuli" uniqKey="Ripatti S" first="Samuli" last="Ripatti">Samuli Ripatti</name><affiliation><nlm:aff id="A12">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A41">Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Cupples, L Adrienne" sort="Cupples, L Adrienne" uniqKey="Cupples L" first="L. Adrienne" last="Cupples">L. Adrienne Cupples</name><affiliation><nlm:aff id="A9">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A204">Framingham Heart Study, Framingham, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Sandhu, Manjinder S" sort="Sandhu, Manjinder S" uniqKey="Sandhu M" first="Manjinder S." last="Sandhu">Manjinder S. Sandhu</name><affiliation><nlm:aff id="A12">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Rich, Stephen S" sort="Rich, Stephen S" uniqKey="Rich S" first="Stephen S." last="Rich">Stephen S. Rich</name><affiliation><nlm:aff id="A205">Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA</nlm:aff></affiliation></author><author><name sortKey="Boehnke, Michael" sort="Boehnke, Michael" uniqKey="Boehnke M" first="Michael" last="Boehnke">Michael Boehnke</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name><affiliation><nlm:aff id="A12">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Mohlke, Karen L" sort="Mohlke, Karen L" uniqKey="Mohlke K" first="Karen L." last="Mohlke">Karen L. Mohlke</name><affiliation><nlm:aff id="A14">Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 USA</nlm:aff></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation><nlm:aff id="A10">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Science for Life Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Abecasis, Goncalo R" sort="Abecasis, Goncalo R" uniqKey="Abecasis G" first="Goncalo R." last="Abecasis">Goncalo R. Abecasis</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Daly, Mark J" sort="Daly, Mark J" uniqKey="Daly M" first="Mark J." last="Daly">Mark J. Daly</name><affiliation><nlm:aff id="A2">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A206">Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02138, USA</nlm:aff></affiliation></author><author><name sortKey="Neale, Benjamin M" sort="Neale, Benjamin M" uniqKey="Neale B" first="Benjamin M." last="Neale">Benjamin M. Neale</name><affiliation><nlm:aff id="A2">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A206">Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02138, USA</nlm:aff></affiliation></author><author><name sortKey="Kathiresan, Sekar" sort="Kathiresan, Sekar" uniqKey="Kathiresan S" first="Sekar" last="Kathiresan">Sekar Kathiresan</name><affiliation><nlm:aff id="A1">Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiologic studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (<italic>P</italic><5×10<sup>−8</sup> for each) to examine the role of triglycerides on risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglycerides, and show that the direction and magnitude of both are factors in determining CAD risk. Second, we consider loci with only a strong magnitude of association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol, a polymorphism's strength of effect on triglycerides is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Murray, Cj" uniqKey="Murray C">CJ Murray</name></author><author><name sortKey="Lopez, Ad" uniqKey="Lopez A">AD Lopez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Di Angelantonio, E" uniqKey="Di Angelantonio E">E Di Angelantonio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sarwar, N" uniqKey="Sarwar N">N Sarwar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sheehan, Na" uniqKey="Sheehan N">NA Sheehan</name></author><author><name sortKey="Didelez, V" uniqKey="Didelez V">V Didelez</name></author><author><name sortKey="Burton, Pr" uniqKey="Burton P">PR Burton</name></author><author><name sortKey="Tobin, Md" uniqKey="Tobin M">MD Tobin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davey Smith, G" uniqKey="Davey Smith G">G Davey Smith</name></author><author><name sortKey="Ebrahim, S" uniqKey="Ebrahim S">S Ebrahim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ebrahim, S" uniqKey="Ebrahim S">S Ebrahim</name></author><author><name sortKey="Davey Smith, G" uniqKey="Davey Smith G">G Davey Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Gd" uniqKey="Smith G">GD Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Gd" uniqKey="Smith G">GD Smith</name></author><author><name sortKey="Ebrahim, S" uniqKey="Ebrahim S">S Ebrahim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cohen, Jc" uniqKey="Cohen J">JC Cohen</name></author><author><name sortKey="Boerwinkle, E" uniqKey="Boerwinkle E">E Boerwinkle</name></author><author><name sortKey="Mosley, Th" uniqKey="Mosley T">TH Mosley</name></author><author><name sortKey="Hobbs, Hh" uniqKey="Hobbs H">HH Hobbs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Willer, Cj" uniqKey="Willer C">CJ Willer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Voight, Bf" uniqKey="Voight B">BF Voight</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haase, Cl" uniqKey="Haase C">CL Haase</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haase, Cl" uniqKey="Haase C">CL Haase</name></author><author><name sortKey="Tybjaerg Hansen, A" uniqKey="Tybjaerg Hansen A">A Tybjaerg-Hansen</name></author><author><name sortKey="Grande, P" uniqKey="Grande P">P Grande</name></author><author><name sortKey="Frikke Schmidt, R" uniqKey="Frikke Schmidt R">R Frikke-Schmidt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frikke Schmidt, R" uniqKey="Frikke Schmidt R">R Frikke-Schmidt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johannsen, Th" uniqKey="Johannsen T">TH Johannsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kathiresan, S" uniqKey="Kathiresan S">S Kathiresan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teslovich, Tm" uniqKey="Teslovich T">TM Teslovich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sarwar, N" uniqKey="Sarwar N">N Sarwar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lewis, Sj" uniqKey="Lewis S">SJ Lewis</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Schunkert, H" uniqKey="Schunkert H">H Schunkert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pennacchio, La" uniqKey="Pennacchio L">LA Pennacchio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kathiresan, S" uniqKey="Kathiresan S">S Kathiresan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pollin, Ti" uniqKey="Pollin T">TI Pollin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deloukas, P" uniqKey="Deloukas P">P Deloukas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, M" uniqKey="Miller M">M Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Varbo, A" uniqKey="Varbo A">A Varbo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilson, Pw" uniqKey="Wilson P">PW Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bosch, J" uniqKey="Bosch J">J Bosch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rubins, Hb" uniqKey="Rubins H">HB Rubins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keech, A" uniqKey="Keech A">A Keech</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ginsberg, Hn" uniqKey="Ginsberg H">HN Ginsberg</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Cook, Rd" uniqKey="Cook R">RD Cook</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id><journal-id journal-id-type="pubmed-jr-id">2419</journal-id><journal-id journal-id-type="nlm-ta">Nat Genet</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Genet.</journal-id><journal-title-group><journal-title>Nature genetics</journal-title></journal-title-group><issn pub-type="ppub">1061-4036</issn><issn pub-type="epub">1546-1718</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24097064</article-id><article-id pub-id-type="pmc">3904346</article-id><article-id pub-id-type="doi">10.1038/ng.2795</article-id><article-id pub-id-type="manuscript">NIHMS524704</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Common variants associated with plasma triglycerides and risk for coronary artery disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Do</surname><given-names>Ron</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib 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contrib-type="author"><name><surname>Ingelsson</surname><given-names>Erik</given-names></name><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A11">11</xref><xref ref-type="aff" rid="A28">28</xref></contrib><contrib contrib-type="author"><name><surname>Abecasis</surname><given-names>Goncalo R.</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Daly</surname><given-names>Mark J.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A206">206</xref><xref rid="FN2" ref-type="author-notes">*</xref><xref rid="FN1" ref-type="author-notes">†</xref></contrib><contrib contrib-type="author"><name><surname>Neale</surname><given-names>Benjamin M.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A206">206</xref><xref rid="FN2" ref-type="author-notes">*</xref><xref rid="FN1" ref-type="author-notes">†</xref></contrib><contrib contrib-type="author"><name><surname>Kathiresan</surname><given-names>Sekar</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref><xref rid="FN2" ref-type="author-notes">*</xref><xref rid="FN1" ref-type="author-notes">†</xref></contrib></contrib-group><aff id="A1"><label>1</label>Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</aff><aff id="A2"><label>2</label>Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</aff><aff id="A3"><label>3</label>Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA</aff><aff id="A4"><label>4</label>Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA</aff><aff id="A5"><label>5</label>Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA</aff><aff id="A6"><label>6</label>Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA</aff><aff id="A7"><label>7</label>Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</aff><aff id="A8"><label>8</label>Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA</aff><aff id="A9"><label>9</label>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA</aff><aff id="A10"><label>10</label>Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden</aff><aff id="A11"><label>11</label>Science for Life Laboratory, Uppsala University, Uppsala, Sweden</aff><aff id="A12"><label>12</label>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom</aff><aff id="A13"><label>13</label>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A14"><label>14</label>Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 USA</aff><aff id="A15"><label>15</label>Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave., Boston MA 02215, USA</aff><aff id="A16"><label>16</label>Harvard Medical School, Boston MA 02115, USA</aff><aff id="A17"><label>17</label>Service of Medical Genetics, Lausanne University Hospital, Lausanne, Switzerland</aff><aff id="A18"><label>18</label>Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland</aff><aff id="A19"><label>19</label>Division of Preventive Medicine and Health Services Research, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan</aff><aff id="A20"><label>20</label>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A21"><label>21</label>Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands</aff><aff id="A22"><label>22</label>Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School. Dundee, DD1 9SY, United Kingdom</aff><aff id="A23"><label>23</label>Cardiology, Department of Specialities of Medicine, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland</aff><aff id="A24"><label>24</label>Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA</aff><aff id="A25"><label>25</label>Estonian Genome Center of the University of Tartu, Tartu, Estonia</aff><aff id="A26"><label>26</label>Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</aff><aff id="A27"><label>27</label>Department of Genetics, Washington University School of Medicine, USA</aff><aff id="A28"><label>28</label>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom</aff><aff id="A29"><label>29</label>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom</aff><aff id="A30"><label>30</label>Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</aff><aff id="A31"><label>31</label>Hjelt Institute, Department of Public Health, University of Helsinki, Finland</aff><aff id="A32"><label>32</label>Centre For Paediatric Epidemiology and Biostatistics/MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London, United Kingdom</aff><aff id="A33"><label>33</label>Centre for Medical Systems Biology, Leiden, the Netherlands</aff><aff id="A34"><label>34</label>Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</aff><aff id="A35"><label>35</label>Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden</aff><aff id="A36"><label>36</label>Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</aff><aff id="A37"><label>37</label>Clinical Pharmacology, NIHR Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry Queen Mary University of London, London, UK</aff><aff id="A38"><label>38</label>Biocenter Oulu, University of Oulu, Oulu, Finland</aff><aff id="A39"><label>39</label>Institute of Health Sciences, University of Oulu, Finland</aff><aff id="A40"><label>40</label>Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland</aff><aff id="A41"><label>41</label>Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland</aff><aff id="A42"><label>42</label>Department of Internal Medicine II – Cardiology, University of Ulm Medical Centre, Ulm, Germany</aff><aff id="A43"><label>43</label>Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, Ludolf-Krehl-Strasse 7-11, 68167 Mannheim, Germany</aff><aff id="A44"><label>44</label>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA</aff><aff id="A45"><label>45</label>MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom</aff><aff id="A46"><label>46</label>Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland</aff><aff id="A47"><label>47</label>Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33014, Finland</aff><aff id="A48"><label>48</label>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</aff><aff id="A49"><label>49</label>Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland</aff><aff id="A50"><label>50</label>Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany</aff><aff id="A51"><label>51</label>Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians University, Munich, Germany</aff><aff id="A52"><label>52</label>Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University of Munich, Munich, Germany</aff><aff id="A53"><label>53</label>Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands</aff><aff id="A54"><label>54</label>Division of Endocrinology, Children's Hospital Boston, Boston, Massachusetts 02115, USA</aff><aff id="A55"><label>55</label>Division of Genetics, Program in Genomics, Children's Hospital Boston, Boston, Massachusetts 02115, USA</aff><aff id="A56"><label>56</label>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, 09042, Italy</aff><aff id="A57"><label>57</label>Center for Neurobehavioral Genetics, The Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, USA</aff><aff id="A58"><label>58</label>Genetic Epidemiology Group, Deparment of Epidemiology and Public Health, UCL, London WC1E 6BT, United Kingdom</aff><aff id="A59"><label>59</label>Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Scania University Hosptial, Malmö, Sweden</aff><aff id="A60"><label>60</label>Department of Odontology, Umeå University, Umeå, Sweden</aff><aff id="A61"><label>61</label>Department of Public Health and Primary Care, Unit of Medicine, Umeå University, Umeå, Sweden</aff><aff id="A62"><label>62</label>Dipartimento di Scienze Biomediche, Universita di Sassari, 07100 SS, Italy</aff><aff id="A63"><label>63</label>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A64"><label>64</label>Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden</aff><aff id="A65"><label>65</label>Clinical Research Branch, National Institute Health, Baltimore, MD, USA</aff><aff id="A66"><label>66</label>deCODE Genetics/Amgen, 101 Reykjavik, Iceland</aff><aff id="A67"><label>67</label>Department of Genetics, University of Pennsylvania - School of Medicine, Philadelphia PA, 19104, USA</aff><aff id="A68"><label>68</label>Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania - School of Medicine, Philadelphia PA, 19104, USA</aff><aff id="A69"><label>69</label>Human Genetics Center, University of Texas Health Science Center - School of Public Health, Houston, TX 77030, USA</aff><aff id="A70"><label>70</label>HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA</aff><aff id="A71"><label>71</label>MRC Unit for Lifelong Health and Ageing, 33 Bedford Place, London, WC1B 5JU, United Kingdom</aff><aff id="A72"><label>72</label>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</aff><aff id="A73"><label>73</label>Ealing Hospital, Southall, Middlesex UB1 3HW, United Kingdom</aff><aff id="A74"><label>74</label>MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda</aff><aff id="A75"><label>75</label>University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Level 4, Institute of Metabolic Science Box 289 Addenbrooke's Hospital Cambridge CB2 OQQ, UK</aff><aff id="A76"><label>76</label>Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</aff><aff id="A77"><label>77</label>Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</aff><aff id="A78"><label>78</label>Department of Experimental Medicine, University of Milano Bicocca, Italy</aff><aff id="A79"><label>79</label>MedStar Health Research Institute, 6525 Belcrest Road, Suite 700, Hyattsville, MD 20782, USA</aff><aff id="A80"><label>80</label>Research Centre on Public Health, University of Milano Bicocca, Italy</aff><aff id="A81"><label>81</label>Department of Dietetics-Nutrition, Harokopio University, 70 El. Venizelou Str, Athens, Greece</aff><aff id="A82"><label>82</label>Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg 85764, Germany</aff><aff id="A83"><label>83</label>Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg 85764, Germany</aff><aff id="A84"><label>84</label>MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, UK</aff><aff id="A85"><label>85</label>The Laboratory in Mjodd, 108 Reykjavik, Iceland</aff><aff id="A86"><label>86</label>Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A87"><label>87</label>Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA</aff><aff id="A88"><label>88</label>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany</aff><aff id="A89"><label>89</label>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, OX3 7LJ, United Kingdom</aff><aff id="A90"><label>90</label>Department of Public Health and Clinical Medicine, Nutritional research, Umeå University, Umeå, Sweden</aff><aff id="A91"><label>91</label>Department of Clinical Sciences/Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland</aff><aff id="A92"><label>92</label>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, United Kingdom</aff><aff id="A93"><label>93</label>Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA</aff><aff id="A94"><label>94</label>Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany</aff><aff id="A95"><label>95</label>Division of Endocrinology & Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan</aff><aff id="A96"><label>96</label>Hannover Unified Biobank, Hannover Medical School, Hannover 30625, Germany</aff><aff id="A97"><label>97</label>Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands</aff><aff id="A98"><label>98</label>Clinical Gerontology Unit, University of Cambridge, Cambridge, United Kingdom</aff><aff id="A99"><label>99</label>Kuopio Research Institute of Exercise Medicine, Kuopio, Finland</aff><aff id="A100"><label>100</label>Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, School of Medicine, National Yang-Ming University, Taipei, Taiwan</aff><aff id="A101"><label>101</label>Diabetes Prevention Unit, National Institute for Health and Welfare, 00271 Helsinki, Finland</aff><aff id="A102"><label>102</label>The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, USA</aff><aff id="A103"><label>103</label>The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, USA</aff><aff id="A104"><label>104</label>The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York</aff><aff id="A105"><label>105</label>School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, United Kingdom</aff><aff id="A106"><label>106</label>Institute for Medical Informatics and Biometrics, University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany</aff><aff id="A107"><label>107</label>Laboratory of Genetics, National Institute on Aging, Baltimore, MD21224, USA</aff><aff id="A108"><label>108</label>Department of Clinical Pharmacology, University of Tampere School of Medicine, Tampere 33014, Finland</aff><aff id="A109"><label>109</label>Department of Internal Medicine, Päijät-Häme Central Hospital, Lahti, Finland</aff><aff id="A110"><label>110</label>Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A111"><label>111</label>Department of Clinical Biochemistry, Landspitali University Hospital, 101 Reykjavik, Iceland</aff><aff id="A112"><label>112</label>Department of Medical Genetics, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A113"><label>113</label>Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom</aff><aff id="A114"><label>114</label>Department of Statistical Sciences, University College of London, London, United Kingdom</aff><aff id="A115"><label>115</label>National Institute for Health and Welfare, Oulu, Finland</aff><aff id="A116"><label>116</label>Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Building 421, Translational Research Center, Philadelphia, PA 19104-5158, USA</aff><aff id="A117"><label>117</label>Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Building 421, Translational Research Center, Philadelphia, PA 19104-5158, USA</aff><aff id="A118"><label>118</label>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands</aff><aff id="A119"><label>119</label>Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands</aff><aff id="A120"><label>120</label>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands</aff><aff id="A121"><label>121</label>Department of Clinical Sciences/Clinical Chemistry, University of Oulu, Oulu, Finland</aff><aff id="A122"><label>122</label>National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK</aff><aff id="A123"><label>123</label>Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, LE3 9QP, UK</aff><aff id="A124"><label>124</label>Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria</aff><aff id="A125"><label>125</label>School of International Development, University of East Anglia, Norwich NR4 7TJ, United Kingdom</aff><aff id="A126"><label>126</label>University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland</aff><aff id="A127"><label>127</label>INSERM UMRS 937, Pierre and Marie Curie University, Paris, France</aff><aff id="A128"><label>128</label>Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, The Netherlands</aff><aff id="A129"><label>129</label>LifeLines Cohort Study, University of Groningen, University Medical Center Groningen, The Netherlands</aff><aff id="A130"><label>130</label>Department of Genetics, University of Groningen, University Medical Center Groningen, The Netherlands</aff><aff id="A131"><label>131</label>Department of Biological Psychology, VU Univ, Amsterdam, The Netherlands</aff><aff id="A132"><label>132</label>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway</aff><aff id="A133"><label>133</label>Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA</aff><aff id="A134"><label>134</label>Department of Epidemiology and Public Health, EA 3430, University of Strasbourg, Faculty of Medicine, Strasbourg, France</aff><aff id="A135"><label>135</label>Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA</aff><aff id="A136"><label>136</label>Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</aff><aff id="A137"><label>137</label>Chemical Pathology, Department of Pathology, University of the West Indies, Mona, Kingston 7, Jamaica</aff><aff id="A138"><label>138</label>Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Route de la Corniche 10, 1010 Lausanne, Switzerland</aff><aff id="A139"><label>139</label>Division of Endocrinology and Diabetes, Department of Internal Medicine, Ulm University Medical Centre, Ulm, Germany</aff><aff id="A140"><label>140</label>Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore</aff><aff id="A141"><label>141</label>Department of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany</aff><aff id="A142"><label>142</label>Ministry of Health, Victoria, Republic of Seychelles</aff><aff id="A143"><label>143</label>Service of Nephrology, Lausanne University Hospital, Lausanne, Switzerland</aff><aff id="A144"><label>144</label>Imperial College Healthcare NHS Trust, London, United Kingdom</aff><aff id="A145"><label>145</label>Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California, USA</aff><aff id="A146"><label>146</label>Department of Medicine, University of California Los Angeles, Los Angeles, California, USA</aff><aff id="A147"><label>147</label>Department of Preventive Medicine and Epidemiology, Loyola University Medical School, Maywood, Illinois 60153, USA</aff><aff id="A148"><label>148</label>Office of Population Studies Foundation, University of San Carlos, Talamban, Cebu City, Philippines</aff><aff id="A149"><label>149</label>Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, France</aff><aff id="A150"><label>150</label>Department of Psychiatry, University of California, Los Angeles, USA</aff><aff id="A151"><label>151</label>Department of Clinical Sciences, Lund University, SE-20502, Malmö, Sweden</aff><aff id="A152"><label>152</label>Department of Medicine, Helsinki University Hospital, FI-00029 Helsinki, Finland</aff><aff id="A153"><label>153</label>Icelandic Heart Association, Kopavogur, Iceland</aff><aff id="A154"><label>154</label>Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden</aff><aff id="A155"><label>155</label>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Ageing, Bethesda, MD, USA</aff><aff id="A156"><label>156</label>Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan</aff><aff id="A157"><label>157</label>Cardiovascular Genetics, BHF Laboratories, Institute Cardiovascular Science, University College London, London, United Kingdom</aff><aff id="A158"><label>158</label>Cardiovascular Genetics, University of Utah School of Medicine, Salt Lake City, UT, USA</aff><aff id="A159"><label>159</label>HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway</aff><aff id="A160"><label>160</label>Kaiser Permanente, Division of Research, Oakland, CA, USA</aff><aff id="A161"><label>161</label>Unit of Primary Care, Oulu University Hospital, Oulu, Finland</aff><aff id="A162"><label>162</label>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland</aff><aff id="A163"><label>163</label>Department of Clinical Physiology, University of Tampere School of Medicine, Tampere 33014, Finland</aff><aff id="A164"><label>164</label>Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland</aff><aff id="A165"><label>165</label>Institute of Clinical Medicine, Department of Medicine, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, Finland</aff><aff id="A166"><label>166</label>National Heart & Lung Institute, Imperial College London, Hammersmith Hospital, London, United Kingdom</aff><aff id="A167"><label>167</label>Children's Hospital Oakland Research Institute, 5700 Martin Luther King Junior Way, Oakland, CA 94609, USA</aff><aff id="A168"><label>168</label>Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland</aff><aff id="A169"><label>169</label>Institute of Regional Health Services Research, University of Southern Denmark, Odense, Denmark</aff><aff id="A170"><label>170</label>Odense Patient data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark</aff><aff id="A171"><label>171</label>Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Finland</aff><aff id="A172"><label>172</label>Department of Medical Sciences, Uppsala University, Uppsala, Sweden</aff><aff id="A173"><label>173</label>Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Queensland 4029, Australia</aff><aff id="A174"><label>174</label>Synlab Academy, Synlab Services GmbH, Gottlieb-Daimler-Straβe 25, 68165 Mannheim, Germany</aff><aff id="A175"><label>175</label>Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston 7, Jamaica</aff><aff id="A176"><label>176</label>U872 Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, 75006 Paris, France</aff><aff id="A177"><label>177</label>Department of Medicine, Kuopio University Hospital, Kuopio, Finland</aff><aff id="A178"><label>178</label>Department of Neurology, General Central Hospital, Bolzano, Italy</aff><aff id="A179"><label>179</label>Department of Neurology, University of Lübeck, Lübeck, Germany</aff><aff id="A180"><label>180</label>Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA</aff><aff id="A181"><label>181</label>Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA</aff><aff id="A182"><label>182</label>Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland</aff><aff id="A183"><label>183</label>Center for Non-Communicable Diseases, Karachi, Pakistan</aff><aff id="A184"><label>184</label>Department of Medicine, University of Pennsylvania, USA</aff><aff id="A185"><label>185</label>Unit of Chronic Disease Epidemiology and Prevention, National Institute for Health and Welfare, Helsinki, Finland</aff><aff id="A186"><label>186</label>South Karelia Central Hospital, Lappeenranta, Finland</aff><aff id="A187"><label>187</label>Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD), Dresden, Germany</aff><aff id="A188"><label>188</label>Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan</aff><aff id="A189"><label>189</label>Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland</aff><aff id="A190"><label>190</label>Faculty of Medicine, University of Iceland, 101 Reykjavík, Iceland</aff><aff id="A191"><label>191</label>Division of Population Health Sciences and Education, St George's, University of London, Cranmer Terrace, London SW17 0RE, United Kingdom</aff><aff id="A192"><label>192</label>Department of Pharmacological Sciences, University of Milan, Monzino Cardiology Center, IRCCS, Milan, Italy</aff><aff id="A193"><label>193</label>Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria</aff><aff id="A194"><label>194</label>King Abdulaziz University, Faculty of Medicine, Jeddah 21589, Saudi Arabia</aff><aff id="A195"><label>195</label>Red RECAVA Grupo RD06/0014/0015, Hospital Universitario La Paz, 28046</aff><aff id="A196"><label>196</label>Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Finland</aff><aff id="A197"><label>197</label>Research Unit, Kuopio University Hospital, Kuopio, Finland</aff><aff id="A198"><label>198</label>Department of Medicine, Lausanne University Hospital, Switzerland</aff><aff id="A199"><label>199</label>Department of Endocrinology, University of Groningen, University Medical Center Groningen, The Netherlands</aff><aff id="A200"><label>200</label>Department of Cardiovascular Epidemiology and Population Genetics, National Center for Cardiovascular Investigation, Madrid, Spain</aff><aff id="A201"><label>201</label>IMDEA-Alimentacion, Madrid, Spain</aff><aff id="A202"><label>202</label>Nutrition and Genomics Laboratory, Jean Mayer-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA</aff><aff id="A203"><label>203</label>Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</aff><aff id="A204"><label>204</label>Framingham Heart Study, Framingham, MA, USA</aff><aff id="A205"><label>205</label>Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA</aff><aff id="A206"><label>206</label>Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02138, USA</aff><author-notes><corresp id="FN1"><label>†</label>Correspondence to: Sekar Kathiresan, M.D. <email>skathiresan@partners.org</email> or Benjamin M. Neale, Ph.D. <email>bneale@broadinstitute.org</email> or Mark J. Daly, Ph.D. <email>mjdaly@atgu.mgh.harvard.edu</email></corresp><fn id="FN2" fn-type="equal"><label>*</label><p>Denotes equal contribution</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>3</day><month>12</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>06</day><month>10</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>11</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>5</month><year>2014</year></pub-date><volume>45</volume><issue>11</issue><fpage>1345</fpage><lpage>1352</lpage><pmc-comment>elocation-id from pubmed: 10.1038/ng.2795</pmc-comment>
<permissions><license><license-p>Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: <ext-link ext-link-type="uri" xlink:href="http://www.nature.com/authors/editorial_policies/license.html#terms">http://www.nature.com/authors/editorial_policies/license.html#terms</ext-link></license-p></license></permissions><abstract><p id="P1">Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiologic studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (<italic>P</italic><5×10<sup>−8</sup> for each) to examine the role of triglycerides on risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglycerides, and show that the direction and magnitude of both are factors in determining CAD risk. Second, we consider loci with only a strong magnitude of association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol, a polymorphism's strength of effect on triglycerides is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.</p></abstract></article-meta></front><body><p id="P2">Coronary artery disease (CAD) is one of the leading causes of death and infirmity worldwide<sup><xref rid="R1" ref-type="bibr">1</xref></sup>. Plasma lipids such as cholesterol and triglycerides are associated with risk for CAD. Cholesterol is mostly carried in either low-density lipoproteins (LDL) or high-density lipoproteins (HDL) whereas triglycerides are mostly transported in very low-density lipoproteins (VLDL), chylomicrons, and remnants of their metabolism.</p><p id="P3">In observational epidemiologic studies, plasma concentrations of increased triglycerides, increased LDL cholesterol (LDL-C), and decreased HDL cholesterol (HDL-C) are associated with increased risk for CAD<sup><xref rid="R2" ref-type="bibr">2</xref>,<xref rid="R3" ref-type="bibr">3</xref></sup>. However, it is difficult to establish causal inference from observational epidemiology<sup><xref rid="R4" ref-type="bibr">4</xref></sup>, especially given the correlations among triglycerides, LDL-C, and HDL-C<sup><xref rid="R3" ref-type="bibr">3</xref></sup>.</p><p id="P4">Single nucleotide polymorphisms (SNPs) can be used as instruments to test whether a biomarker causally relates to disease risk<sup><xref rid="R5" ref-type="bibr">5</xref>,<xref rid="R6" ref-type="bibr">6</xref></sup>. Because genotypes are randomly assigned at meiosis and fixed throughout lifetime, a genetic association may overcome some limitations of observational epidemiology such as confounding and reverse causation<sup><xref rid="R7" ref-type="bibr">7</xref>,<xref rid="R8" ref-type="bibr">8</xref></sup>. Using gene variants that exclusively affect a biomarker of interest (i.e., no pleiotropic effects on other factors), investigators have confirmed LDL-C as a causal risk factor for CAD<sup><xref rid="R9" ref-type="bibr">9</xref></sup> and have cast doubt on whether HDL-C directly influences risk for CAD<sup><xref rid="R10" ref-type="bibr">10</xref>-<xref rid="R15" ref-type="bibr">15</xref></sup>.</p><p id="P5">However, to date, it has been challenging to utilize a similar approach to define if plasma triglycerides reflect processes causal for CAD. In contrast to LDL-C and HDL-C, nearly all SNPs identified to date for plasma triglycerides have additional effects on either plasma LDL-C or HDL-C<sup><xref rid="R16" ref-type="bibr">16</xref>-<xref rid="R18" ref-type="bibr">18</xref></sup>, violating the “no pleiotropy” assumption of instrumental variable analysis<sup><xref rid="R8" ref-type="bibr">8</xref>,<xref rid="R19" ref-type="bibr">19</xref></sup>.</p><p id="P6">Here, we utilize common variants and develop a statistical framework to dissect causal influences among a set of correlated biomarkers. As this approach requires a large set of SNPs where precise measurements of effect on triglycerides, LDL-C, HDL-C, and CAD risk are simultaneously available, we leveraged: 1) 185 common SNPs all representing independent loci that are associated with at least one lipid trait at genome-wide levels of significance; 2) estimates of effect of each SNP on plasma triglycerides, LDL-C, and HDL-C in a sample exceeding 180,000 individuals; and 3) estimates of effect of each SNP on CAD in a sample exceeding 86,000 individuals (22,233 cases and 64,762 controls).</p><p id="P7">We studied 185 SNPs at 157 one megabase pair intervals with association <italic>P</italic><5×10<sup>−8</sup> for triglycerides, LDL-C, or HDL-C in a meta-analysis involving 188,578 genotyped individuals (see companion manuscript<sup><xref rid="R20" ref-type="bibr">20</xref></sup>). For each SNP, we obtained effect estimates for triglycerides (β<sub>TRIGLYCERIDES</sub>), LDL-C (β<sub>LDL-C</sub>), and HDL-C (β<sub>HDL-C</sub>) (in standard deviation units and estimated using inverse normal transformed residuals of lipid levels after adjusting for covariates; see <xref rid="SD1" ref-type="supplementary-material">Supplementary Figure 1</xref> for study design). We also estimated the effect of each SNP on CAD (β<sub>CAD</sub>) from a recently published genome-wide association study (GWAS) involving 86,995 individuals (the CARDIoGRAM study)<sup><xref rid="R21" ref-type="bibr">21</xref></sup>. For the 185 SNPs, effect sizes (β) and <italic>P</italic>-values for triglycerides, LDL-C, HDL-C, and CAD are shown in <xref rid="SD1" ref-type="supplementary-material">Supplementary Table 1</xref>.</p><p id="P8">We considered several analytic approaches to investigate whether plasma triglycerides reflect processes causal for CAD. First, we evaluated the direction and magnitude of β<sub>LDL-C</sub> and β<sub>TRIGLYCERIDES</sub> in combination, and then compared these to β<sub>CAD</sub> (<xref rid="F1" ref-type="fig">Figure 1</xref> and <xref rid="SD1" ref-type="supplementary-material">Supplementary Figure 2</xref>). Second, to isolate the effect of triglycerides, from the 185 SNPs, we restricted analysis to loci that have moderate to strong effect on triglycerides (large β<sub>TRIGLYCERIDES</sub>) but minimal effect on LDL-C (small β<sub>LDL-C</sub>). Finally, across the 185 SNPs, we formally developed and applied a statistical framework to test if the effect size of a SNP on triglycerides is linearly related to its effect size on CAD, before and after accounting for the same SNP's potential effect on plasma LDL-C and/or HDL-C.</p><p id="P9">For each of the 185 independent lipid SNPs, we evaluated joint patterns of associations for triglycerides and LDL-C by examining SNPs that have strong association to both triglycerides and LDL-C (<italic>P</italic><5×10<sup>−8</sup>for each). Among these, we examined SNPs with the same direction and a similar magnitude of association for both lipid traits (within a factor of 5). We observed 11 loci with this pattern of association. Five loci confer risk for CAD (<italic>P</italic><0.05) and ten of the eleven loci show a direction of effect consistent between the lipid traits and CAD (<xref rid="T1" ref-type="table">Table 1</xref>). For example, the A allele at rs2954022 in the <italic>TRIB1</italic> gene was associated strongly with lower triglycerides (β<sub>TRIGLYCERIDES</sub>=−0.078, <italic>P</italic>=2×10<sup>−124</sup>) and lower LDL-C (β<sub>LDL-C</sub>=−0.055, <italic>P</italic>=4×10<sup>−51</sup>) and showed the expected association with lower CAD risk (β<sub>CAD</sub>=−0.056, <italic>P</italic>=6×10<sup>−5</sup>).</p><p id="P10">Next, we identified SNPs that had strong association with both triglycerides and LDL-C (<italic>P</italic><5×10<sup>−8</sup> for each) but had opposite directions for β<sub>TRIGLYCERIDES</sub> and β<sub>LDL-C</sub> (within a factor of 5, <xref rid="T2" ref-type="table">Table 2</xref>). Four SNPs displayed this pattern and none showed significant association with CAD (all <italic>P</italic>>0.05). For example, the A allele at rs2255141 in the <italic>GPAM</italic> gene was associated with lower triglycerides (β<sub>TRIGLYCERIDES</sub>=−0.021, <italic>P</italic>=1×10<sup>−8</sup>) and higher LDL-C (β<sub>LDL-C</sub>=0.030, <italic>P</italic>=<italic>7</italic>×10<sup>−14</sup>) but had no discernible effect on CAD risk (β<sub>CAD</sub> =−0.0076, <italic>P</italic>=0.63).</p><p id="P11">Secondly, we considered a subset of the 185 SNPs that have moderate to strong effects on triglycerides but minimal effect on LDL-C [n=44 SNPs, all SNPs have large <italic>β</italic><sub>TRIGLYCERIDES</sub> (>0.01 or <−0.01) but small <italic>β</italic><sub>LDL-C</sub> (between −0.01 and 0.01)]. In regression analysis, we confirmed that <italic>β</italic><sub>LDL-C</sub> was not associated with <italic>β</italic><sub>CAD</sub> for this set of SNPs (<italic>P</italic>=0.68; see <xref rid="SD1" ref-type="supplementary-material">Supplementary Table 2</xref>). However, we observed a significant association of <italic>β</italic><sub>TRIGLYCERIDES</sub> and <italic>β</italic><sub>CAD</sub> (<italic>P</italic>=3×10<sup>−5</sup>; see <xref rid="SD1" ref-type="supplementary-material">Supplementary Table 3</xref>). These observations suggest that the direction and magnitude of effect of a SNP on both triglycerides and LDL-C impact risk for CAD.</p><p id="P12">To formally investigate whether the strength of a SNP's association with triglycerides predicts CAD risk, we devised a statistical framework that controls for pleiotropic effects on secondary lipid traits. This approach is particularly important because SNP association signals with triglycerides, LDL-C, and/or HDL-C (β<sub>TRIGLYCERIDES,</sub> β<sub>LDL-C</sub>, and β<sub>HDL-C</sub>) are correlated (<xref rid="SD1" ref-type="supplementary-material">Supplementary Figure 3</xref> and <xref rid="SD1" ref-type="supplementary-material">Supplementary Table 4</xref>).</p><p id="P13">We tested the role of triglycerides on CAD by first calculating residuals of β<sub>CAD</sub> after including as covariates β<sub>LDL-C</sub> and β<sub>HDL-C</sub> in our regression model (<xref rid="SD1" ref-type="supplementary-material">Supplementary Figure 1</xref>). We then tested the association of β<sub>TRIGLYCERIDES</sub> with β<sub>CAD</sub> residuals. Similar models were created to assess the independent roles of LDL-C and HDL-C.</p><p id="P14">We observed that across the 185 SNPs, β<sub>LDL-C</sub> was strongly associated with β<sub>CAD</sub>, after adjusting for either β<sub>TRIGLYCERIDES</sub> individually, β<sub>HDL-C</sub> individually, or both β<sub>TRIGLYCERIDES</sub> and β<sub>HDL-C</sub> (all <italic>P</italic> < 1×10<sup>−18</sup>, <xref rid="T3" ref-type="table">Table 3</xref>). The pattern for β<sub>HDL-C</sub> was different. Across the 185 SNPs, β<sub>HDL-C</sub> was associated with β<sub>CAD</sub>, after adjusting for β<sub>LDL-C</sub> (<italic>P</italic>=0.005); however, this association was greatly attenuated after adjusting for β<sub>TRIGLYCERIDES</sub> individually (<italic>P</italic>=0.057) and rendered non-significant after accounting for both β<sub>TRIGLYCERIDES</sub> and β<sub>LDL-C</sub> (<italic>P</italic>=0.35, <xref rid="T3" ref-type="table">Table 3</xref>).</p><p id="P15">The results for triglycerides were similar to those observed for LDL-C. Across the 185 SNPs, β<sub>TRIGLYCERIDES</sub> was strongly associated with β<sub>CAD</sub>, after adjusting for both β<sub>LDL-C</sub> and β<sub>HDL-C</sub> (<italic>P</italic> =1×10<sup>−9</sup>, <xref rid="T3" ref-type="table">Table 3</xref>).</p><p id="P16">As an alternative to this approach using residuals, we also tested a single model with the outcome variable of β<sub>CAD</sub> and predictor variables of β<sub>TRIGLYCERIDES</sub>, β<sub>LDL-C</sub> and β<sub>HDL-C</sub> considered jointly (<xref rid="SD1" ref-type="supplementary-material">Supplementary Table 5</xref>). Results were similar with β<sub>TRIGLYCERIDES</sub> and β<sub>LDL-C</sub> showing association with β<sub>CAD</sub> (<italic>P</italic>=2×10<sup>−10</sup> and <italic>P</italic>=1×10<sup>−22</sup>, respectively) but β<sub>HDL-C</sub> failing to show association (P=0.32).</p><p id="P17">In summary, we have demonstrated that: 1) SNPs with the same direction and a similar magnitude of association for both triglycerides and LDL-C tend to associate with CAD risk; 2) loci that have an exclusive effect on triglycerides are also associated with CAD; and 3) the strength of a SNP's effect on triglycerides is correlated with the magnitude of its effect on CAD risk, even after accounting for the same SNP's effect on LDL-C and/or HDL-C.</p><p id="P18">Using an analytical approach that accounts for the potential pleiotropic effects of a SNP on triglycerides, LDL-C, and/or HDL-C, we provide evidence that plasma triglycerides likely reflects processes causal for CAD. This finding based on 185 common SNPs is in line with recent reports of specific genes predominantly related to triglycerides also affecting risk for CAD. A promoter SNP in the <italic>APOA5</italic> gene<sup><xref rid="R22" ref-type="bibr">22</xref></sup>, a common SNP upstream of the <italic>TRIB1</italic> gene<sup><xref rid="R23" ref-type="bibr">23</xref></sup>, and a nonsense polymorphism at the <italic>APOC3</italic> gene<sup><xref rid="R24" ref-type="bibr">24</xref></sup> all predominantly associate with plasma triglycerides and each SNP has been convincingly related to clinical CAD<sup><xref rid="R11" ref-type="bibr">11</xref>,<xref rid="R25" ref-type="bibr">25</xref></sup> or subclinical atherosclerosis<sup><xref rid="R24" ref-type="bibr">24</xref></sup>.</p><p id="P19">Our results raise several questions. First, if plasma triglycerides reflect causal processes, what are the specific mechanistic direct links to atherosclerosis? Triglycerides are carried in plasma mostly in VLDL, chylomicrons and remnants of their metabolism and as such, triglycerides capture several physiologic processes that may promote atherosclerosis. One potential link is post-prandial cholesterol metabolism. Plasma triglycerides are highly correlated with the amount of cholesterol in remnant lipoproteins (i.e., VLDL and chylomicron particles after interaction with lipoprotein lipase) and a variety of evidence ranging from the human Mendelian disorder of Type III hyperlipoproteinemia to experimental evidence in cell culture and animal models suggests that cholesterol-rich remnant particles have pro-atherogenic properties similar to LDL (reviewed in <sup><xref rid="R26" ref-type="bibr">26</xref></sup>). Another process reflected by plasma triglycerides is the activity of lipoprotein lipase, a key enzyme that hydrolyzes triglycerides within triglyceride-rich lipoproteins. Higher enzymatic activity of lipoprotein lipase in the circulation leads to lower plasma triglycerides; a gain-of-function nonsense polymorphism in the <italic>LPL</italic> gene has been shown to not only reduce plasma triglyceride levels but also lower risk for CAD<sup><xref rid="R27" ref-type="bibr">27</xref></sup>.</p><p id="P20">Second, why are plasma triglycerides not significantly associated with CAD in observational epidemiologic studies when multiple risk factors are considered jointly to predict risk for future CAD<sup><xref rid="R2" ref-type="bibr">2</xref></sup>? Multivariable models have known limitations for assessing the etiological relevance for a given exposure. For example, an exposure may be rendered non-significant after multivariable adjustment because of less precise measurement or greater biologic variability when compared with other factors. Plasma triglyceride measurements are more variable than other plasma lipids such as HDL-C<sup><xref rid="R26" ref-type="bibr">26</xref></sup>. Alternatively, downstream effects of an exposure may more completely capture the risk conferred. For example, body mass index does not predict CAD risk in the Framingham model after accounting for blood pressure and type 2 diabetes despite the accepted causal influence of weight on blood pressure and type 2 diabetes<sup><xref rid="R28" ref-type="bibr">28</xref></sup>. Our approach using SNPs as proxies overcomes these limitations of observational epidemiology.</p><p id="P21">Finally, what are the implications of these data for the development of drugs aimed at lowering plasma triglycerides with the hope of reducing CAD risk? Several recent randomized controlled trials have tested whether the lowering of plasma triglycerides with fish oils<sup><xref rid="R29" ref-type="bibr">29</xref></sup> or with fibrates<sup><xref rid="R30" ref-type="bibr">30</xref>-<xref rid="R32" ref-type="bibr">32</xref></sup> will decrease risk for CAD and in many cases, treatment did not reduce risk<sup><xref rid="R29" ref-type="bibr">29</xref>,<xref rid="R31" ref-type="bibr">31</xref>,<xref rid="R32" ref-type="bibr">32</xref></sup>. Possible explanations for failed trials are wrong study population, wrong mechanism of lowering triglycerides, insufficient degree of triglyceride-lowering, and limited statistical power.</p><p id="P22">Our study has several limitations. SNPs associated with triglycerides also relate to other lipid traits and thus, are not ideal instruments for Mendelian randomization analysis. Given that the plasma triglycerides measured in the blood is the end product of several metabolic processes, it is not surprising that triglyceride-related SNPs affect at least one other lipid trait. We have attempted to address this complexity through our statistical approach.</p><p id="P23">We are unable to distinguish if only specific mechanisms of altering triglycerides affect risk for CAD. Of note, there is strong evidence that at least three mechanisms that robustly influence triglycerides – loss of APOA5 function, loss of TRIB1 function, and gain of APOC3 function –increase risk for CAD.</p><p id="P24">In summary, we utilize common polymorphisms and employ a statistical framework to dissect causal influences among a set of correlated biomarkers. By applying this framework to a correlated set of plasma lipid measures and CAD risk, we suggest a causal role of triglyceride-rich lipoproteins in the development of CAD.</p><sec id="S1" specific-use="web-only"><title>Online Methods</title><p id="P25">For the association of a given SNP with a plasma lipid trait, we obtained estimates of the effect size (β<sub>TRIGLYCERIDES,</sub> β<sub>LDL-C</sub> and β<sub>HDL-C</sub>) and strength of association (<italic>P</italic>-value) from a meta-analysis of association results from genome-wide and custom-array genotyping – the Global Lipids Genetics Consortium (GLGC) Metabochip study (described in companion manuscript, Willer et al.<sup><xref rid="R20" ref-type="bibr">20</xref></sup>). All effect sizes are in standard deviation units from inverse normal transformed residuals of lipids after adjusting for covariates. This analysis included up to 188,578 individuals from 60 studies. For the association of a given SNP with coronary artery disease (CAD), we obtained estimates of the effect size (β<sub>CAD</sub>) and strength of association (<italic>P</italic>-value) from a published GWAS study for CAD, the CARDIoGRAM study<sup><xref rid="R21" ref-type="bibr">21</xref></sup>. This study included 22,233 cases and 63,762 controls.</p><p id="P26">We selected independent SNPs associated with plasma lipids using the following criteria. First, we restricted to SNPs with association with at least one of the three lipid traits (triglycerides, LDL-C or HDL-C) at a genome-wide significance level of <italic>P</italic><5×10<sup>−8</sup>. For each lipid locus – defined as a region of the genome that has a cluster of associated SNPs within one megabase from each other – we selected the strongest associated SNP (‘lead’ SNP). For loci with multiple associated SNPs, we calculated pairwise linkage disequilibrium (LD) estimates (r<sup><xref rid="R2" ref-type="bibr">2</xref></sup>) of these SNPs using whole genome sequencing data from 85 Utah residents with ancestryfrom northern and western Europe (CEU) samples from the 1000 Genomes project<sup><xref rid="R33" ref-type="bibr">33</xref></sup>, and selected a second SNP if there was very low LD (r<sup><xref rid="R2" ref-type="bibr">2</xref></sup><0.05) with the lead SNP. In total, we selected 185 SNPs that met these criteria. These criteria yield a conservative estimate of the number of independent lipid SNPs. A list of effect sizes and <italic>P</italic>-values for triglycerides, LDL-C, HDL-C and CAD for the 185 selected SNPs is shown in <xref rid="SD1" ref-type="supplementary-material">Supplementary Table 1</xref>.</p><p id="P27">To formally investigate whether the strength of a SNP's association with triglycerides predicts CAD risk, we performed linear regression on the effect sizes of each SNP for triglycerides (β<sub>TRIGLYCERIDES</sub>), LDL-C (β<sub>LDL-C</sub>), HDL-C (β<sub>HDL-C</sub>) as predictor variables, and the effect sizes of CAD (β<sub>CAD</sub>) as the outcome variable. To control for pleiotropic effects, we first calculated the residuals of β<sub>CAD</sub> after adjusting for covariates of β<sub>TRIGLYCERIDES,</sub> β<sub>LDL-C</sub> and/or β<sub>HDL-C</sub>. We then performed linear regression analysis in a second model on the effect size of the primary lipid trait (β<sub>TRIGLYCERIDES,</sub> β<sub>LDL-C</sub> or β<sub>HDL-C</sub>) with the residuals of β<sub>CAD</sub>. For example, to test for the role of LDL-C on CAD, we first calculated residuals of β<sub>CAD</sub> after including as covariates β<sub>TRIGLYCERIDES</sub> and β<sub>HDL-C</sub> in our regression model. In a second regression model, we then performed association of residual β<sub>CAD</sub> with β<sub>LDL-C.</sub> All possible combinations of linear regression analysis was performed between β<sub>TRIGLYCERIDES</sub>, β<sub>LDL-C</sub> or β<sub>HDL-C</sub> on β<sub>CAD</sub> (see <xref rid="T3" ref-type="table">Table 3</xref>).</p><p id="P28">As an alternative to this residuals approach, we also tested a single model where the outcome variable of β<sub>CAD</sub> was tested with the predictor variables of β<sub>TRIGLYCERIDES</sub>, β<sub>LDL-C</sub> and β<sub>HDL-C</sub> jointly considered (<xref rid="SD1" ref-type="supplementary-material">Supplementary Table 5</xref>). We also performed several sensitivity analyses to test for the effect of using different thresholds on β<sub>TRIGLYCERIDES</sub> and β<sub>LDL-C</sub> when highlighting loci with associations for both triglycerides and LDL-C (<xref rid="SD1" ref-type="supplementary-material">Supplementary Table 6, 7 and 8</xref>). We used thresholds that yielded the highest number of SNPs for each statistical analysis (factor threshold of 5 in <xref rid="T1" ref-type="table">Table 1</xref> and <xref rid="T2" ref-type="table">Table 2</xref>, and <italic>β</italic> cutoff value of 0.01 in <xref rid="SD1" ref-type="supplementary-material">Supplementary Table 2 and 3</xref>). Furthermore, we assessed the effect of extreme influential outliers using Cook's D statistic<sup><xref rid="R34" ref-type="bibr">34</xref></sup> (<xref rid="SD1" ref-type="supplementary-material">Supplementary Figure 4</xref> and <xref rid="SD1" ref-type="supplementary-material">Supplementary Table 9</xref>) on our conditional regression models (<xref rid="T3" ref-type="table">Table 3</xref>). A list of the number of SNPs included in each of the different analyses are shown in <xref rid="SD1" ref-type="supplementary-material">Supplementary Table 10</xref>.</p></sec><sec sec-type="supplementary-material" id="S2"><title>Supplementary Material</title><supplementary-material content-type="local-data" id="SD1"><label>1</label><media xlink:href="NIHMS524704-supplement-1.pdf" mimetype="application" mime-subtype="pdf" orientation="portrait" xlink:type="simple" id="d37e4100" position="anchor"></media></supplementary-material></sec></body><back><ack id="S3"><p>We thank the Global Lipids Genetics Consortium for early access to the association results of the Metabochip study. S.Kathiresan is supported by a Research Scholar award from the Massachusetts General Hospital (MGH), the Howard Goodman Fellowship from MGH, the Donovan Family Foundation, R01HL107816, and a grant from Fondation Leducq. R.D. is supported by a Banting Fellowship from the Canadian Institutes of Health Research. G.P. is supported by Award Number T32HL007208 from the National Heart, Lung, and Blood Institute. 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Kathiresan serves on scientific advisory boards for Merck, Celera, American Genomics and Catabasis. He has received unrestricted research grants from Merck and Pfizer.</p></sec></app><app id="APP3"><title>Author Contributions</title><sec id="S8"><title></title><p id="P35">R.D. carried out primary data analyses and prepared the <xref rid="SD1" ref-type="supplementary-material">supplementary information</xref>. R.D. and C.G. prepared figures and tables. C.W., E.M.S., S.Sebanti, G.R.A. contributed meta-analysis results. R.D., M.J.D, B.M.N., S.Kathiresan contributed to the design and conduct of the study. 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Altshuler, S.Kathiresan; (METSIM) J.Kuusisto, M.L.; (MICROS) P.P.P.; (MORGAM) D.Arveiler, J.F.; (MRC/UVRI GPC GWAS) P.Kaleebu, G.A., J.Seeley, E.H.Y.; (MRC National Survey of Health & Development) D.K.; (NFBC1986) M-R.J.; (NSPHS) U.G.; (ORCADES) H.Campbell; (PARC) Y.I.C., R.M.K., J.I.R.; (PIVUS) E.I., L.Lind; (PROMIS) J.D., P.D., D.Saleheen; (Rotterdam Study) A.Hofman, A.G.U.; (SardiNIA) G.R.A.; (SCARFSHEEP) A.Hamsten, U.D.; (SEYCHELLES) M.Burnier, M.Bochud; P.Bovet; (SUVIMAX) P.M.; (Swedish Twin Reg.) E.I., N.L.P.; (TAICHI) T.L.A., Y.I.C., C.A.H., T.Q., J.I.R., W.H.S.; (THISEAS) G.D., P.D.; (Tromsø) I.N.; (TWINGENE) U.D., E.I.; (ULSAM) E.I.; (Whitehall II) A.Hingorani, M.Kivimaki</p></sec><sec id="S10"><title>Genotyping of contributing cohorts</title><p id="P38">(ADVANCE) D.Absher; (AIDHS/SDS) L.F.B., M.L.G.; (AMC-PAS) P.D., G.K.H.; (B58C-WTCCC & B58C-T1DGC) W.L.M.; (B58C-Metabochip) M.I.M.; (BLSA) D.H.; (BRIGHT) P.B.M.; (CHS) J.I.R.; (DIAGEN) N.N., G.M.; (DILGOM) A. Palotie; (DR's EXTRA) T.A.L.; (EAS) J.F.W.; (EGCUT (Estonian Genome Center of University of Tartu)) T.E.; (EPIC) P.D.; (EPIC_N_SUBCOH GWAS) I.B.; (ERF) C.M.V.; (ESS (Erasmus Stroke Study)) C.M.V.; (FBPP) A.C., G.B.E.; (FENLAND) M.S.S.; (FIN-D2D 2007) A.J.S.; (FINCAVAS) T.L.; (Framingham) J.M.O.; (FUSION stage 2) L.L.B.; (GLACIER) I.B.; (Go-DARTS) C.Groves, C.N.P., M.I.M.; (IMPROVE) A.Hamsten; (KORAF3) H.G., T.I.; (KORAF4) N.K.; (LifeLines) C.W.; (LOLIPOP) J.S.K., J.C.C.; (LURIC) M.E.K.; (MDC) B.F.V., R.D.; (MICROS) A.A.H.; (MORGAM) L.T., P.Brambilla; (MRC/UVRI GPC GWAS) M.S.S.; (MRC National Survey of Health & Development) A.W., D.K., K.K.O.; (NFBC1986) A-L.H., M.J, M.McCarthy, P.E., S.V.; (NSPHS and FRISCII) Å.J.; (ORCADES) H.Campbell; (PARC) M.O.G., M.R.J., J.I.R.; (PIVUS) E.I., L.Lind; (PROMIS) P.D., K.Stirrups; (Rotterdam Study) A.G.U., F.R.; (SardiNIA) R.N.; (SCARFSHEEP) B.G., R.J.S.; (SEYCHELLES) F.M., G.B.E.; (Swedish Twin Reg.) E.I., N.L.P.; (TAICHI) D.Absher, T.L.A., E.K., T.Q., L.L.W.; (THISEAS) P.D.; (TWINGENE) A.Hamsten, E.I.; (ULSAM) E.I.; (WGHS) D.I.C., P.M.R.; (Whitehall II) A.Hingorani, C.L., M.Kumari, M.Kivimaki</p></sec><sec id="S11"><title>Phenotype definition of contributing cohorts</title><p id="P39">(ADVANCE) C.I.; (AGES Reykjavik study) T.B.H., V.G.; (AIDHS/SDS) L.F.B.; (AMC-PAS) J.J.K.; (Amish GLGC) A.R.S., B.D.M.; (B58C-WTCCC & B58C-T1DGC) D.P.S.; (B58C-Metabochip) C.Power; E.H.; (BRIGHT) P.B.M.; (CHS) B.M.P.; (CoLaus) P.V.; (deCODE) G.I.E., H.H., I.O.; (DIAGEN) G.M.; (DILGOM) K.Silander; (DPS) J.Lindström; (DR's EXTRA) P.Komulainen; (EAS) J.L.Bolton; (EGCUT (Estonian Genome Center of University of Tartu)) A.M.; (EGCUT (Estonian Genome Center of University of Tartu)) K.F.; (ERF and Rotterdam Study) A.Hofman; (ERF) C.M.V; (ESS (Erasmus Stroke Study)) E.G.V., H.M.D., P.J.K.; (FBPP) A.C., R.S.C., S.C.H.; (FINCAVAS) T.V.N.; (Framingham) S.Kathiresan, J.M.O.; (GenomEUTwin: MZGWA) J.B.W.; (GenomEUTwin-FINRISK) V.S.; (GenomEUTwin-FINTWIN) J.Kaprio, K.Heikkilä; (GenomEUTwin-GENMETS) A.Jula; (GenomEUTwin-NLDTWIN) G.W.; (Go-DARTS) A.S.D., A.D.M., C.N.P., L.A.D.; (GxE/Spanish Town) C.A.M., F.B.; (IMPROVE) U.D.; A.Hamsten, E.T.; (KORAF3) C.M.; (KORAF4) A.Döring; (LifeLines) L.J.; (LOLIPOP) J.S.K., J.C.C.; (LURIC) H.S.; (MDC) L.C.G.; (METSIM) A.Stančáková; (MORGAM) G.C.; (MRC/UVRI GPC GWAS) R.N.N.; (MRC National Survey of Health & Development) D.K.; (NFBC1986) A.R., A-L.H., A.Pouta, M-R.J.; (NSPHS and FRISCII) Å.J.; (NSPHS) U.G.; (ORCADES) S.H.W.; (PARC) Y.I.C., R.M.K.; (PIVUS) E.I., L.Lind; (PROMIS) D.F.F.; (Rotterdam Study) A.Hofman; (SCARFSHEEP) U.D., B.G.; (SEYCHELLES) M.Burnier, M.Bochud, P.Bovet; (Swedish Twin Reg.) E.I., N.L.P.; (TAICHI) H.Chang, C.A.H., Y.H., E.K., S.L., W.H.S.; (THISEAS) G.D., M.D.; (Tromsø) T.W.; (TWINGENE) U.D., E.I.; (ULSAM) E.I.; (WGHS) P.M.R.; (Whitehall II) M.Kumari</p></sec><sec id="S12"><title>Primary analysis from contributing cohorts</title><p id="P40">(ADVANCE) L.L.W.; (AIDHS/SDS) R.S.; (AMC-PAS) S.Kanoni; (Amish GLGC) J.R.O., M.E.M.; (ARIC) K.A.V.; (B58C-Metabochip) C.M.L., E.H., T.F.; (B58C-WTCCC & B58C-T1DGC) D.P.S.; (BLSA) T.T.; (BRIGHT) T.J.; (CLHNS) Y.W.; (CoLaus) J.S.B.; (deCODE) G.T.; (DIAGEN) A.U.J.; (DILGOM) M.P.; (EAS) R.M.F.; (DPS) A.U.J.; (DR'S EXTRA) A.U.J.; (EGCUT (Estonian Genome Center of University of Tartu)) E.M., K.F., T.E.; (ELY) D.G.; (EPIC) K.Stirrups, D.G.; (EPIC_N_OBSET GWAS) E.Y., C.L.; (EPIC_N_SUBCOH GWAS) N.W.; (ERF) A.I.; (ESS (Erasmus Stroke Study)) C.M.V., E.G.V.; (EUROSPAN) A.Demirkan; (Family Heart Study FHS) I.B.B., M.F.F.; (FBPP) A.C., G.B.E.; (FENLAND) T.P., C.Pomilla; (FENLAND GWAS) J.H.Z., J.Luan; (FIN-D2D 2007) A.U.J.; (FINCAVAS) L.Lyytikäinen; (Framingham) L.A.C., G.M.P.; (FRISCII and NSPHS) Å.J.; (FUSION stage 2) T.M.T.; (GenomEUTwin-FINRISK) J.Kettunen; (GenomEUTwin-FINTWIN) K.Heikkilä; (GenomEUTwin-GENMETS) I.S.; (GenomEUTwin-SWETWIN) P.K.M.; (GenomEUTwin-UK-TWINS) M.Mangino; (GLACIER) D.Shungin; (GLACIER) P.W.F.; (Go-DARTS) C.N.P., L.A.D.; (GxE/Spanish Town) C.D.P.; (HUNT) A.U.J.; (IMPROVE) R.J.S.; (InCHIANTI) T.T.; (KORAF3) M.Müller-Nurasyid; (KORAF4) A.Petersen; (LifeLines) I.M.N.; (LOLIPOP) W.Z.; (LURIC) M.E.K.; (MDC) B.F.V.; (MDC) P.F., R.D.; (METSIM) A.U.J.; (MRC/UVRI GPC GWAS) R.N.N.; (MRC National Survey of Health & Development) A.W., J.Luan; (NFBC1986) M.Kaakinen, I.S., S.K.S.; (NSPHS and FRISCII) Å.J.; (PARC) X.L.; (PIVUS) C.Song, E.I.; (PROMIS) J.D., D.F.F., K.Stirrups; (Rotterdam Study) A.I.; (SardiNIA) C.Sidore, J.L.Bragg-Gresham, S.Sanna; (SCARFSHEEP) R.J.S.; (SEYCHELLES) G.B.E., M.Bochud; (SUVIMAX) T.J.; (Swedish Twin Reg.) C.Song, E.I.; (TAICHI) D.Absher, T.L.A., H.Chang, M.G., C.A.H., T.Q., L.L.W; (THISEAS) S.Kanoni; (Tromsø) A.U.J.; (TWINGENE) A.G., E.I.; (ULSAM) C.Song, E.I., S.G.; (WGHS) D.I.C.; (Whitehall II) S.Shah</p></sec></app></app-group></back><floats-group><fig id="F1" orientation="portrait" position="float"><label>Figure 1</label><caption><title>Effect of a single nucleotide polymorphism on triglycerides, low-density lipoprotein cholesterol, and risk for coronary artery disease</title><p>Black dots represent SNPs with CAD <italic>P</italic><0.001; B. Red dots represent SNPs with 0.01 < CAD <italic>P</italic> <0.001; C. Grey dots represent CAD <italic>P</italic>>0.10). Loci strongly associated with CAD tend to have consistent directions for both triglycerides and LDL-C (bottom left and top right quadrants). In contrast to the grey points, the black and red points are concentrated in the bottom left and top right quadrants. Betas are in standard deviation units. SNPs with −0.10<β<sub>LDL-C</sub><0.10 and −0.10<β<sub>TRIGLYCERIDES</sub><0.10 are shown.</p></caption><graphic xlink:href="nihms524704f1"></graphic></fig><table-wrap id="T1" orientation="landscape" position="float"><label>Table 1</label><caption><p>SNPs with consistent direction of genetic effects on LDL-C and triglycerides and their subsequent relationship to risk for CAD.</p></caption><table frame="hsides" rules="groups"><thead><tr><th valign="top" align="center" rowspan="1" colspan="1"></th><th valign="top" align="center" rowspan="1" colspan="1"></th><th valign="top" align="center" rowspan="1" colspan="1"></th><th colspan="2" valign="top" align="center" rowspan="1">LDL-C</th><th colspan="2" valign="top" align="center" rowspan="1">TRIGLYCERIDES</th><th colspan="2" valign="top" align="center" rowspan="1">CAD</th></tr><tr><th valign="top" align="center" rowspan="1" colspan="1">Locus</th><th valign="top" align="center" rowspan="1" colspan="1">rs ID</th><th valign="top" align="center" rowspan="1" colspan="1">A1</th><th valign="top" align="center" rowspan="1" colspan="1">β<sub>LDL-C</sub></th><th valign="top" align="center" rowspan="1" colspan="1"><italic>P</italic></th><th valign="top" align="center" rowspan="1" colspan="1">β<sub>TRIGLYCERIDES</sub></th><th valign="top" align="center" rowspan="1" colspan="1"><italic>P</italic></th><th valign="top" align="center" rowspan="1" colspan="1">β<sub>CAD</sub></th><th valign="top" align="center" rowspan="1" colspan="1"><italic>P</italic></th></tr></thead><tbody><tr><td align="center" valign="top" rowspan="1" colspan="1"><italic>ANGPTL3</italic></td><td align="center" valign="top" rowspan="1" colspan="1">rs4587594</td><td align="center" valign="top" rowspan="1" colspan="1">A</td><td align="center" valign="top" rowspan="1" colspan="1">−0.049</td><td align="center" valign="top" rowspan="1" colspan="1">3×10<sup>−37</sup></td><td align="center" valign="top" rowspan="1" colspan="1">−0.069</td><td align="center" valign="top" rowspan="1" colspan="1">3×10<sup>−87</sup></td><td align="center" valign="top" rowspan="1" colspan="1">0.017</td><td align="center" valign="top" rowspan="1" colspan="1">0.26</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><italic>APOB</italic></td><td align="center" valign="top" rowspan="1" colspan="1">rs1367117</td><td align="center" valign="top" rowspan="1" colspan="1">A</td><td align="center" valign="top" rowspan="1" colspan="1">0.12</td><td align="center" valign="top" rowspan="1" colspan="1">2×10<sup>−196</sup></td><td align="center" valign="top" rowspan="1" colspan="1">0.025</td><td align="center" valign="top" rowspan="1" colspan="1">3×10<sup>−12</sup></td><td align="center" valign="top" rowspan="1" colspan="1">0.035</td><td align="center" valign="top" rowspan="1" colspan="1">0.02</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><italic>GCKR</italic></td><td align="center" valign="top" rowspan="1" colspan="1">rs3817588</td><td align="center" valign="top" rowspan="1" colspan="1">T</td><td align="center" valign="top" rowspan="1" colspan="1">0.026</td><td align="center" valign="top" rowspan="1" colspan="1">3×10<sup>−8</sup></td><td align="center" valign="top" rowspan="1" colspan="1">0.067</td><td align="center" valign="top" rowspan="1" colspan="1">7×10<sup>−58</sup></td><td align="center" valign="top" rowspan="1" colspan="1">0.034</td><td align="center" valign="top" rowspan="1" colspan="1">0.08</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><italic>TIMD4</italic></td><td align="center" valign="top" rowspan="1" colspan="1">rs6882076</td><td align="center" valign="top" rowspan="1" colspan="1">T</td><td align="center" valign="top" rowspan="1" colspan="1">−0.046</td><td align="center" valign="top" rowspan="1" colspan="1">5×10<sup>−33</sup></td><td align="center" valign="top" rowspan="1" colspan="1">−0.029</td><td align="center" valign="top" rowspan="1" colspan="1">1×10<sup>−16</sup></td><td align="center" valign="top" rowspan="1" colspan="1">−0.021</td><td align="center" valign="top" rowspan="1" colspan="1">0.15</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><italic>HLA-B</italic></td><td align="center" valign="top" rowspan="1" colspan="1">rs2247056</td><td align="center" valign="top" rowspan="1" colspan="1">T</td><td align="center" valign="top" rowspan="1" colspan="1">−0.025</td><td align="center" valign="top" rowspan="1" colspan="1">6×10<sup>−9</sup></td><td align="center" valign="top" rowspan="1" colspan="1">−0.038</td><td align="center" valign="top" rowspan="1" colspan="1">2×10<sup>−22</sup></td><td align="center" valign="top" rowspan="1" colspan="1">−0.030</td><td align="center" valign="top" rowspan="1" colspan="1">0.06</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><italic>TRIB1</italic></td><td align="center" valign="top" rowspan="1" colspan="1">rs2980885</td><td align="center" valign="top" rowspan="1" colspan="1">A</td><td align="center" valign="top" rowspan="1" colspan="1">−0.031</td><td align="center" valign="top" rowspan="1" colspan="1">4×10<sup>−12</sup></td><td align="center" valign="top" rowspan="1" colspan="1">−0.058</td><td align="center" valign="top" rowspan="1" colspan="1">5×10<sup>−45</sup></td><td align="center" valign="top" rowspan="1" colspan="1">−0.041</td><td align="center" valign="top" rowspan="1" colspan="1">0.02</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><italic>TRIB1</italic></td><td align="center" valign="top" rowspan="1" colspan="1">rs2954022</td><td align="center" valign="top" rowspan="1" colspan="1">A</td><td align="center" valign="top" rowspan="1" colspan="1">−0.055</td><td align="center" valign="top" rowspan="1" colspan="1">4×10<sup>−51</sup></td><td align="center" valign="top" rowspan="1" colspan="1">−0.078</td><td align="center" valign="top" rowspan="1" colspan="1">2×10<sup>−124</sup></td><td align="center" valign="top" rowspan="1" colspan="1">−0.056</td><td align="center" valign="top" rowspan="1" colspan="1">6×10<sup>−5</sup></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><italic>ABCA1</italic></td><td align="center" valign="top" rowspan="1" colspan="1">rs1883025</td><td align="center" valign="top" rowspan="1" colspan="1">T</td><td align="center" valign="top" rowspan="1" colspan="1">−0.030</td><td align="center" valign="top" rowspan="1" colspan="1">1×10<sup>−11</sup></td><td align="center" valign="top" rowspan="1" colspan="1">−0.022</td><td align="center" valign="top" rowspan="1" colspan="1">3×10<sup>−8</sup></td><td align="center" valign="top" rowspan="1" colspan="1">−0.014</td><td align="center" valign="top" rowspan="1" colspan="1">0.41</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><italic>APOA1</italic></td><td align="center" valign="top" rowspan="1" colspan="1">rs10790162</td><td align="center" valign="top" rowspan="1" colspan="1">A</td><td align="center" valign="top" rowspan="1" colspan="1">0.076</td><td align="center" valign="top" rowspan="1" colspan="1">3×10<sup>−26</sup></td><td align="center" valign="top" rowspan="1" colspan="1">0.23</td><td align="center" valign="top" rowspan="1" colspan="1">1×10<sup>−276</sup></td><td align="center" valign="top" rowspan="1" colspan="1">0.13</td><td align="center" valign="top" rowspan="1" colspan="1">2×10<sup>−6</sup></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><italic>CETP</italic></td><td align="center" valign="top" rowspan="1" colspan="1">rs9989419</td><td align="center" valign="top" rowspan="1" colspan="1">A</td><td align="center" valign="top" rowspan="1" colspan="1">0.028</td><td align="center" valign="top" rowspan="1" colspan="1">8×10<sup>−13</sup></td><td align="center" valign="top" rowspan="1" colspan="1">0.024</td><td align="center" valign="top" rowspan="1" colspan="1">3×10<sup>−12</sup></td><td align="center" valign="top" rowspan="1" colspan="1">0.010</td><td align="center" valign="top" rowspan="1" colspan="1">0.61</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><italic>CILP2</italic></td><td align="center" valign="top" rowspan="1" colspan="1">rs10401969</td><td align="center" valign="top" rowspan="1" colspan="1">T</td><td align="center" valign="top" rowspan="1" colspan="1">0.12</td><td align="center" valign="top" rowspan="1" colspan="1">2×10<sup>−60</sup></td><td align="center" valign="top" rowspan="1" colspan="1">0.12</td><td align="center" valign="top" rowspan="1" colspan="1">3×10<sup>−76</sup></td><td align="center" valign="top" rowspan="1" colspan="1">0.11</td><td align="center" valign="top" rowspan="1" colspan="1">2×10<sup>−4</sup></td></tr></tbody></table><table-wrap-foot><fn id="TFN1"><p>Shown are SNPs that have strong association with both LDL-C and triglycerides (<italic>P</italic><5×10<sup>−8</sup> for each), have consistent direction of effect size for LDL-C and triglycerides, and have a ratio of magnitude of effect size of LDL-C to triglycerides within a factor of 5.Five loci confer risk for CAD (<italic>P</italic><0.05) and ten of the eleven loci show consistent direction of effect size for both lipid traits with the effect size of CAD.</p><p>A1: All beta estimates were calculated with respect to this allele.</p></fn></table-wrap-foot></table-wrap><table-wrap id="T2" orientation="landscape" position="float"><label>Table 2</label><caption><p>SNPs with opposite direction of genetic effects on LDL-C and triglycerides and their subsequent relationship to risk for CAD.</p></caption><table frame="hsides" rules="groups"><thead><tr><th valign="top" align="center" rowspan="1" colspan="1"></th><th valign="top" align="center" rowspan="1" colspan="1"></th><th valign="top" align="center" rowspan="1" colspan="1"></th><th colspan="2" valign="top" align="center" rowspan="1">LDL-C</th><th colspan="2" valign="top" align="center" rowspan="1">TRIGLYCERIDES</th><th colspan="2" valign="top" align="center" rowspan="1">CAD</th></tr><tr><th valign="top" align="center" rowspan="1" colspan="1">Locus</th><th valign="top" align="center" rowspan="1" colspan="1">rs ID</th><th valign="top" align="center" rowspan="1" colspan="1">A1</th><th valign="top" align="center" rowspan="1" colspan="1">β<sub>LDL-C</sub></th><th valign="top" align="center" rowspan="1" colspan="1"><italic>P</italic></th><th valign="top" align="center" rowspan="1" colspan="1">β<sub>TRIGLYCERIDES</sub></th><th valign="top" align="center" rowspan="1" colspan="1"><italic>P</italic></th><th valign="top" align="center" rowspan="1" colspan="1">β<sub>CAD</sub></th><th valign="top" align="center" rowspan="1" colspan="1"><italic>P</italic></th></tr></thead><tbody><tr><td align="center" valign="top" rowspan="1" colspan="1"><italic>MIR148A</italic></td><td align="center" valign="top" rowspan="1" colspan="1">rs4722551</td><td align="center" valign="top" rowspan="1" colspan="1">T</td><td align="center" valign="top" rowspan="1" colspan="1">−0.039</td><td align="center" valign="top" rowspan="1" colspan="1">7×10<sup>−16</sup></td><td align="center" valign="top" rowspan="1" colspan="1">0.027</td><td align="center" valign="top" rowspan="1" colspan="1">2×10<sup>−9</sup></td><td align="center" valign="top" rowspan="1" colspan="1">−0.033</td><td align="center" valign="top" rowspan="1" colspan="1">0.23</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><italic>GPAM</italic></td><td align="center" valign="top" rowspan="1" colspan="1">rs2255141</td><td align="center" valign="top" rowspan="1" colspan="1">A</td><td align="center" valign="top" rowspan="1" colspan="1">0.030</td><td align="center" valign="top" rowspan="1" colspan="1">7×10<sup>−14</sup></td><td align="center" valign="top" rowspan="1" colspan="1">−0.021</td><td align="center" valign="top" rowspan="1" colspan="1">1×10<sup>−8</sup></td><td align="center" valign="top" rowspan="1" colspan="1">−0.0076</td><td align="center" valign="top" rowspan="1" colspan="1">0.63</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><italic>FADS1-2-3</italic></td><td align="center" valign="top" rowspan="1" colspan="1">rs1535</td><td align="center" valign="top" rowspan="1" colspan="1">A</td><td align="center" valign="top" rowspan="1" colspan="1">0.053</td><td align="center" valign="top" rowspan="1" colspan="1">3×10<sup>−43</sup></td><td align="center" valign="top" rowspan="1" colspan="1">−0.046</td><td align="center" valign="top" rowspan="1" colspan="1">1×10<sup>−40</sup></td><td align="center" valign="top" rowspan="1" colspan="1">0.0019</td><td align="center" valign="top" rowspan="1" colspan="1">0.90</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><italic>APOE</italic></td><td align="center" valign="top" rowspan="1" colspan="1">rs7254892</td><td align="center" valign="top" rowspan="1" colspan="1">A</td><td align="center" valign="top" rowspan="1" colspan="1">−0.49</td><td align="center" valign="top" rowspan="1" colspan="1">8×10<sup>−365</sup></td><td align="center" valign="top" rowspan="1" colspan="1">0.12</td><td align="center" valign="top" rowspan="1" colspan="1">4×10<sup>−31</sup></td><td align="center" valign="top" rowspan="1" colspan="1">−0.14</td><td align="center" valign="top" rowspan="1" colspan="1">0.09</td></tr></tbody></table><table-wrap-foot><fn id="TFN2"><p>Shown are SNPs that have strong association with both LDL-C and triglycerides (P<5×10<sup>−8</sup> for each), but have opposite direction of effect size for LDL-C and triglycerides, and have a ratio of magnitude of effect size of LDL-C to triglycerides within a factor of 5. Four SNPs displayed this pattern and none showed significant association with CAD (all <italic>P</italic>>0.05).</p><p>A1: All beta estimates were calculated with respect to this allele.</p></fn></table-wrap-foot></table-wrap><table-wrap id="T3" orientation="landscape" position="float"><label>Table 3</label><caption><p>Association of the strength of a SNP's effect on plasma lipids with its strength of effect on CAD risk.</p></caption><table frame="hsides" rules="groups"><thead><tr><th valign="top" align="center" rowspan="1" colspan="1">Outcome</th><th valign="top" align="center" rowspan="1" colspan="1">Predictor</th><th valign="top" align="center" rowspan="1" colspan="1">Covariate</th><th valign="top" align="center" rowspan="1" colspan="1">Beta</th><th valign="top" align="center" rowspan="1" colspan="1">SE</th><th valign="top" align="center" rowspan="1" colspan="1">P</th></tr></thead><tbody><tr><td align="center" valign="top" rowspan="1" colspan="1">β<sub>CAD</sub></td><td align="center" valign="top" rowspan="1" colspan="1">β<sub>LDL-C</sub></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">0.41</td><td align="center" valign="top" rowspan="1" colspan="1">0.039</td><td align="center" valign="top" rowspan="1" colspan="1">4×10<sup>−20</sup></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">β<sub>CAD</sub></td><td align="center" valign="top" rowspan="1" colspan="1">β<sub>LDL-C</sub></td><td align="center" valign="top" rowspan="1" colspan="1">β<sub>HDL-C</sub></td><td align="center" valign="top" rowspan="1" colspan="1">0.38</td><td align="center" valign="top" rowspan="1" colspan="1">0.039</td><td align="center" valign="top" rowspan="1" colspan="1">9×10<sup>−19</sup></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">β<sub>CAD</sub></td><td align="center" valign="top" rowspan="1" colspan="1">β<sub>LDL-C</sub></td><td align="center" valign="top" rowspan="1" colspan="1">β<sub>TRIGLYCERIDES</sub></td><td align="center" valign="top" rowspan="1" colspan="1">0.40</td><td align="center" valign="top" rowspan="1" colspan="1">0.034</td><td align="center" valign="top" rowspan="1" colspan="1">1×10<sup>−23</sup></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">β<sub>CAD</sub></td><td align="center" valign="top" rowspan="1" colspan="1">β<sub>LDL-C</sub></td><td align="center" valign="top" rowspan="1" colspan="1">β<sub>HDL-C</sub>, β<sub>TRIGLYCERIDES</sub></td><td align="center" valign="top" rowspan="1" colspan="1">0.38</td><td align="center" valign="top" rowspan="1" colspan="1">0.034</td><td align="center" valign="top" rowspan="1" colspan="1">2×10<sup>−22</sup></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">β<sub>CAD</sub></td><td align="center" valign="top" rowspan="1" colspan="1">β<sub>HDL-C</sub></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">−0.18</td><td align="center" valign="top" rowspan="1" colspan="1">0.052</td><td align="center" valign="top" rowspan="1" colspan="1">0.0006</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">β<sub>CAD</sub></td><td align="center" valign="top" rowspan="1" colspan="1">β<sub>HDL-C</sub></td><td align="center" valign="top" rowspan="1" colspan="1">β<sub>LDL-C</sub></td><td align="center" valign="top" rowspan="1" colspan="1">−0.12</td><td align="center" valign="top" rowspan="1" colspan="1">0.041</td><td align="center" valign="top" rowspan="1" colspan="1">0.005</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">β<sub>CAD</sub></td><td align="center" valign="top" rowspan="1" colspan="1">β<sub>HDL-C</sub></td><td align="center" valign="top" rowspan="1" colspan="1">β<sub>TRIGLYCERIDES</sub></td><td align="center" valign="top" rowspan="1" colspan="1">−0.09</td><td align="center" valign="top" rowspan="1" colspan="1">0.048</td><td align="center" valign="top" rowspan="1" colspan="1">0.057</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">β<sub>CAD</sub></td><td align="center" valign="top" rowspan="1" colspan="1">β<sub>HDL-C</sub></td><td align="center" valign="top" rowspan="1" colspan="1">β<sub>LDL-C</sub>, β<sub>TRIGLYCERIDES</sub></td><td align="center" valign="top" rowspan="1" colspan="1">−0.04</td><td align="center" valign="top" rowspan="1" colspan="1">0.037</td><td align="center" valign="top" rowspan="1" colspan="1">0.35</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">β<sub>CAD</sub></td><td align="center" valign="top" rowspan="1" colspan="1">β<sub>TRIGLYCERIDES</sub></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">0.44</td><td align="center" valign="top" rowspan="1" colspan="1">0.074</td><td align="center" valign="top" rowspan="1" colspan="1">2×10<sup>−8</sup></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">β<sub>CAD</sub></td><td align="center" valign="top" rowspan="1" colspan="1">β<sub>TRIGLYCERIDES</sub></td><td align="center" valign="top" rowspan="1" colspan="1">β<sub>LDL-C</sub></td><td align="center" valign="top" rowspan="1" colspan="1">0.42</td><td align="center" valign="top" rowspan="1" colspan="1">0.057</td><td align="center" valign="top" rowspan="1" colspan="1">5×10<sup>−12</sup></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">β<sub>CAD</sub></td><td align="center" valign="top" rowspan="1" colspan="1">β<sub>TRIGLYCERIDES</sub></td><td align="center" valign="top" rowspan="1" colspan="1">β<sub>HDL-C</sub></td><td align="center" valign="top" rowspan="1" colspan="1">0.36</td><td align="center" valign="top" rowspan="1" colspan="1">0.074</td><td align="center" valign="top" rowspan="1" colspan="1">3×10<sup>−6</sup></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">β<sub>CAD</sub></td><td align="center" valign="top" rowspan="1" colspan="1">β<sub>TRIGLYCERIDES</sub></td><td align="center" valign="top" rowspan="1" colspan="1">β<sub>LDL-C</sub>, β<sub>HDL-C</sub></td><td align="center" valign="top" rowspan="1" colspan="1">0.36</td><td align="center" valign="top" rowspan="1" colspan="1">0.057</td><td align="center" valign="top" rowspan="1" colspan="1">1×10<sup>−9</sup></td></tr></tbody></table><table-wrap-foot><fn id="TFN3"><p>Residuals for β<sub>CAD</sub> were calculated after adjustment of a SNP's effect on the denoted lipid trait. A total of 185 SNPs identified from GWAS for LDL-C, HDL-C and triglycerides were included in regression analysis. β<sub>LDL-C</sub>, β<sub>HDL-C</sub>, and β<sub>TRIGLYCERIDES</sub> represent the effect sizes for a SNP on LDL-C, HDL-C and triglycerides in the GWAS meta-analysis for lipids. Regression was performed with the predictor variable of the effect size on lipid traits (β from predictor column) and the outcome variable of residual CAD effect size after adjusting for covariates. SE: standard error.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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