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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture</title><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Gustafsson, Stefan" sort="Gustafsson, Stefan" uniqKey="Gustafsson S" first="Stefan" last="Gustafsson">Stefan Gustafsson</name><affiliation><nlm:aff id="A2">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</nlm:aff></affiliation></author><author><name sortKey="Ganna, Andrea" sort="Ganna, Andrea" uniqKey="Ganna A" first="Andrea" last="Ganna">Andrea Ganna</name><affiliation><nlm:aff id="A3">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Wheeler, Eleanor" sort="Wheeler, Eleanor" uniqKey="Wheeler E" first="Eleanor" last="Wheeler">Eleanor Wheeler</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Feitosa, Mary F" sort="Feitosa, Mary F" uniqKey="Feitosa M" first="Mary F." last="Feitosa">Mary F. Feitosa</name><affiliation><nlm:aff id="A7">Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Justice, Anne E" sort="Justice, Anne E" uniqKey="Justice A" first="Anne E." last="Justice">Anne E. Justice</name><affiliation><nlm:aff id="A8">Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, USA</nlm:aff></affiliation></author><author><name sortKey="Monda, Keri L" sort="Monda, Keri L" uniqKey="Monda K" first="Keri L." last="Monda">Keri L. Monda</name><affiliation><nlm:aff id="A8">Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Center for Observational Research, Amgen, Thousands Oaks, CA, 91320</nlm:aff></affiliation></author><author><name sortKey="Croteau Chonka, Damien C" sort="Croteau Chonka, Damien C" uniqKey="Croteau Chonka D" first="Damien C." last="Croteau-Chonka">Damien C. Croteau-Chonka</name><affiliation><nlm:aff id="A10">Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA</nlm:aff></affiliation></author><author><name sortKey="Day, Felix R" sort="Day, Felix R" uniqKey="Day F" first="Felix R." last="Day">Felix R. Day</name><affiliation><nlm:aff id="A11">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Fall, Tove" sort="Fall, Tove" uniqKey="Fall T" first="Tove" last="Fall">Tove Fall</name><affiliation><nlm:aff id="A3">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Ferreira, Teresa" sort="Ferreira, Teresa" uniqKey="Ferreira T" first="Teresa" last="Ferreira">Teresa Ferreira</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Gentilini, Davide" sort="Gentilini, Davide" uniqKey="Gentilini D" first="Davide" last="Gentilini">Davide Gentilini</name><affiliation><nlm:aff id="A13">Molecular Biology Department, Istituto Auxologico Italiano, Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Jackson, Anne U" sort="Jackson, Anne U" uniqKey="Jackson A" first="Anne U." last="Jackson">Anne U. Jackson</name><affiliation><nlm:aff id="A14">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Luan, Jian N" sort="Luan, Jian N" uniqKey="Luan J" first="Jian N" last="Luan">Jian N Luan</name><affiliation><nlm:aff id="A11">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Randall, Joshua C" sort="Randall, Joshua C" uniqKey="Randall J" first="Joshua C." last="Randall">Joshua C. Randall</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Vedantam, Sailaja" sort="Vedantam, Sailaja" uniqKey="Vedantam S" first="Sailaja" last="Vedantam">Sailaja Vedantam</name><affiliation><nlm:aff id="A15">Divisions of Genetics and Endocrinology and Center for Basic and Translational Obesity Research, Children’s Hospital, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Willer, Cristen J" sort="Willer, Cristen J" uniqKey="Willer C" first="Cristen J." last="Willer">Cristen J. Willer</name><affiliation><nlm:aff id="A18">Department of Internal Medicine (Cardiovascular), University of Michigan, Ann Arbor, MI 48109, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Department of Computational Medicine and Bioinformatics, University of Michigan, MI 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Winkler, Thomas W" sort="Winkler, Thomas W" uniqKey="Winkler T" first="Thomas W." last="Winkler">Thomas W. Winkler</name><affiliation><nlm:aff id="A21">Public Health and Gender Studies, Institute of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Wood, Andrew R" sort="Wood, Andrew R" uniqKey="Wood A" first="Andrew R." last="Wood">Andrew R. Wood</name><affiliation><nlm:aff id="A22">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, EX1 2LU, UK</nlm:aff></affiliation></author><author><name sortKey="Workalemahu, Tsegaselassie" sort="Workalemahu, Tsegaselassie" uniqKey="Workalemahu T" first="Tsegaselassie" last="Workalemahu">Tsegaselassie Workalemahu</name><affiliation><nlm:aff id="A23">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Hu, Yi Juan" sort="Hu, Yi Juan" uniqKey="Hu Y" first="Yi-Juan" last="Hu">Yi-Juan Hu</name><affiliation><nlm:aff id="A25">Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia 30322, USA</nlm:aff></affiliation></author><author><name sortKey="Lee, Sang Hong" sort="Lee, Sang Hong" uniqKey="Lee S" first="Sang Hong" last="Lee">Sang Hong Lee</name><affiliation><nlm:aff id="A26">The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Liang, Liming" sort="Liang, Liming" uniqKey="Liang L" first="Liming" last="Liang">Liming Liang</name><affiliation><nlm:aff id="A27">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Lin, Dan Yu" sort="Lin, Dan Yu" uniqKey="Lin D" first="Dan-Yu" last="Lin">Dan-Yu Lin</name><affiliation><nlm:aff id="A29">Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff></affiliation></author><author><name sortKey="Min, Josine L" sort="Min, Josine L" uniqKey="Min J" first="Josine L." last="Min">Josine L. Min</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Neale, Benjamin M" sort="Neale, Benjamin M" uniqKey="Neale B" first="Benjamin M." last="Neale">Benjamin M. Neale</name><affiliation><nlm:aff id="A30">Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114</nlm:aff></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation><nlm:aff id="A31">deCODE Genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Yang, Jian" sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name><affiliation><nlm:aff id="A32">University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Queensland Institute of Medical Research, Brisbane 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Albrecht, Eva" sort="Albrecht, Eva" uniqKey="Albrecht E" first="Eva" last="Albrecht">Eva Albrecht</name><affiliation><nlm:aff id="A34">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation><nlm:aff id="A35">Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Bragg Gresham, Jennifer L" sort="Bragg Gresham, Jennifer L" uniqKey="Bragg Gresham J" first="Jennifer L." last="Bragg-Gresham">Jennifer L. Bragg-Gresham</name><affiliation><nlm:aff id="A14">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Cadby, Gemma" sort="Cadby, Gemma" uniqKey="Cadby G" first="Gemma" last="Cadby">Gemma Cadby</name><affiliation><nlm:aff id="A36">Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research. Toronto, Canada, M5G 1L7</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Toronto, Canada, M5G 1X5</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="Den Heijer, Martin" sort="Den Heijer, Martin" uniqKey="Den Heijer M" first="Martin" last="Den Heijer">Martin Den Heijer</name><affiliation><nlm:aff id="A39">Department of Internal Medicine, VU University Medical Centre, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Eklund, Niina" sort="Eklund, Niina" uniqKey="Eklund N" first="Niina" last="Eklund">Niina Eklund</name><affiliation><nlm:aff id="A40">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</nlm:aff></affiliation></author><author><name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name><affiliation><nlm:aff id="A41">Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Oxford, OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation><nlm:aff id="A42">Department of Biological Psychology, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Huffman, Jennifer E" sort="Huffman, Jennifer E" uniqKey="Huffman J" first="Jennifer E." last="Huffman">Jennifer E. Huffman</name><affiliation><nlm:aff id="A43">MRC Human Genetics Unit, MRC Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, UK</nlm:aff></affiliation></author><author><name sortKey="Jarick, Ivonne" sort="Jarick, Ivonne" uniqKey="Jarick I" first="Ivonne" last="Jarick">Ivonne Jarick</name><affiliation><nlm:aff id="A44">Institute of Medical Biometry and Epidemiology, University of Marburg, 35037 Marburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation><nlm:aff id="A45">Department of Immunology, Genetics and Pathology, Uppsala University, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A46">Uppsala Clinical Research Center, Uppsala university hospital, Sweden</nlm:aff></affiliation></author><author><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name><affiliation><nlm:aff id="A47">Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kanoni, Stavroula" sort="Kanoni, Stavroula" uniqKey="Kanoni S" first="Stavroula" last="Kanoni">Stavroula Kanoni</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E." last="Kleber">Marcus E. Kleber</name><affiliation><nlm:aff id="A49">LURIC Study nonprofit LLC, Freiburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A50">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Konig, Inke R" sort="Konig, Inke R" uniqKey="Konig I" first="Inke R." last="König">Inke R. König</name><affiliation><nlm:aff id="A51">Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, 23562 Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Kristiansson, Kati" sort="Kristiansson, Kati" uniqKey="Kristiansson K" first="Kati" last="Kristiansson">Kati Kristiansson</name><affiliation><nlm:aff id="A40">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name><affiliation><nlm:aff id="A52">Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A53">Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Lamina, Claudia" sort="Lamina, Claudia" uniqKey="Lamina C" first="Claudia" last="Lamina">Claudia Lamina</name><affiliation><nlm:aff id="A54">Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria</nlm:aff></affiliation></author><author><name sortKey="Lecoeur, Cecile" sort="Lecoeur, Cecile" uniqKey="Lecoeur C" first="Cecile" last="Lecoeur">Cecile Lecoeur</name><affiliation><nlm:aff id="A55">University Lille Nord de France, 59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A56">CNRS UMR8199-IBL-Institut Pasteur de Lille, F-59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name><affiliation><nlm:aff id="A57">Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA</nlm:aff></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation><nlm:aff id="A58">Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L." last="Mcardle">Wendy L. Mcardle</name><affiliation><nlm:aff id="A59">School of Social and Community Medicine, University of Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Medina Gomez, Carolina" sort="Medina Gomez, Carolina" uniqKey="Medina Gomez C" first="Carolina" last="Medina-Gomez">Carolina Medina-Gomez</name><affiliation><nlm:aff id="A35">Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A60">Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name><affiliation><nlm:aff id="A34">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A63">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology and Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Ngwa, Julius S" sort="Ngwa, Julius S" uniqKey="Ngwa J" first="Julius S." last="Ngwa">Julius S. Ngwa</name><affiliation><nlm:aff id="A64">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M." last="Nolte">Ilja M. Nolte</name><affiliation><nlm:aff id="A65">Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Paternoster, Lavinia" sort="Paternoster, Lavinia" uniqKey="Paternoster L" first="Lavinia" last="Paternoster">Lavinia Paternoster</name><affiliation><nlm:aff id="A66">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Pechlivanis, Sonali" sort="Pechlivanis, Sonali" uniqKey="Pechlivanis S" first="Sonali" last="Pechlivanis">Sonali Pechlivanis</name><affiliation><nlm:aff id="A67">Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital of Essen, University of Duisburg-Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A40">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Peters, Marjolein J" sort="Peters, Marjolein J" uniqKey="Peters M" first="Marjolein J." last="Peters">Marjolein J. Peters</name><affiliation><nlm:aff id="A35">Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A60">Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Preuss, Michael" sort="Preuss, Michael" uniqKey="Preuss M" first="Michael" last="Preuss">Michael Preuss</name><affiliation><nlm:aff id="A51">Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, 23562 Lübeck, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A69">Universität zu Lübeck, Medizinische Klinik II, 23538 Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Rose, Lynda M" sort="Rose, Lynda M" uniqKey="Rose L" first="Lynda M." last="Rose">Lynda M. Rose</name><affiliation><nlm:aff id="A70">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts 02215, USA</nlm:aff></affiliation></author><author><name sortKey="Shi, Jianxin" sort="Shi, Jianxin" uniqKey="Shi J" first="Jianxin" last="Shi">Jianxin Shi</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Shungin, Dmitry" sort="Shungin, Dmitry" uniqKey="Shungin D" first="Dmitry" last="Shungin">Dmitry Shungin</name><affiliation><nlm:aff id="A71">Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Lund University, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Department of Public Health & Clinical Medicine, Umeå University, Umeå, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Department of Odontology, Umeå University, Sweden</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name><affiliation><nlm:aff id="A74">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A75">Department of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Strawbridge, Rona J" sort="Strawbridge, Rona J" uniqKey="Strawbridge R" first="Rona J." last="Strawbridge">Rona J. Strawbridge</name><affiliation><nlm:aff id="A76">Atherosclerosis Research Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Surakka, Ida" sort="Surakka, Ida" uniqKey="Surakka I" first="Ida" last="Surakka">Ida Surakka</name><affiliation><nlm:aff id="A40">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:aff id="A77">Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, 17487 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Trip, Mieke D" sort="Trip, Mieke D" uniqKey="Trip M" first="Mieke D." last="Trip">Mieke D. Trip</name><affiliation><nlm:aff id="A78">Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A79">Heart Failure Research Centre, Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Tyrer, Jonathan" sort="Tyrer, Jonathan" uniqKey="Tyrer J" first="Jonathan" last="Tyrer">Jonathan Tyrer</name><affiliation><nlm:aff id="A80">Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Van Vliet Ostaptchouk, Jana V" sort="Van Vliet Ostaptchouk, Jana V" uniqKey="Van Vliet Ostaptchouk J" first="Jana V." last="Van Vliet-Ostaptchouk">Jana V. Van Vliet-Ostaptchouk</name><affiliation><nlm:aff id="A81">Department of Endocrinology, University Medical Center Groningen, University of Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A82">LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Vandenput, Liesbeth" sort="Vandenput, Liesbeth" uniqKey="Vandenput L" first="Liesbeth" last="Vandenput">Liesbeth Vandenput</name><affiliation><nlm:aff id="A83">Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Waite, Lindsay L" sort="Waite, Lindsay L" uniqKey="Waite L" first="Lindsay L." last="Waite">Lindsay L. Waite</name><affiliation><nlm:aff id="A84">Hudson Alpha Institute for Biotechnology, Huntsville, Alabama 35806, USA</nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="A11">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Absher, Devin" sort="Absher, Devin" uniqKey="Absher D" first="Devin" last="Absher">Devin Absher</name><affiliation><nlm:aff id="A84">Hudson Alpha Institute for Biotechnology, Huntsville, Alabama 35806, USA</nlm:aff></affiliation></author><author><name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W." last="Asselbergs">Folkert W. Asselbergs</name><affiliation><nlm:aff id="A85">Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Atalay, Mustafa" sort="Atalay, Mustafa" uniqKey="Atalay M" first="Mustafa" last="Atalay">Mustafa Atalay</name><affiliation><nlm:aff id="A86">Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Finland</nlm:aff></affiliation></author><author><name sortKey="Attwood, Antony P" sort="Attwood, Antony P" uniqKey="Attwood A" first="Antony P." last="Attwood">Antony P. Attwood</name><affiliation><nlm:aff id="A87">NIHR Cambridge Biomedical Research Centre, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Balmforth, Anthony J" sort="Balmforth, Anthony J" uniqKey="Balmforth A" first="Anthony J." last="Balmforth">Anthony J. Balmforth</name><affiliation><nlm:aff id="A88">Division of Epidemiology, Multidisciplinary Cardiovascular Research Centre (MCRC), Leeds Institute of Genetics, Health and Therapeutics (LIGHT), University of Leeds, Leeds LS2 9JT, UK</nlm:aff></affiliation></author><author><name sortKey="Basart, Hanneke" sort="Basart, Hanneke" uniqKey="Basart H" first="Hanneke" last="Basart">Hanneke Basart</name><affiliation><nlm:aff id="A78">Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Beilby, John" sort="Beilby, John" uniqKey="Beilby J" first="John" last="Beilby">John Beilby</name><affiliation><nlm:aff id="A89">PathWest Laboratory of Western Australia, Department of Molecular Genetics, J Block, QEII Medical Centre, Nedlands, Western Australia 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A90">Department of Surgery and Pathology, University of Western Australia, Nedlands, Australia, 6009</nlm:aff></affiliation></author><author><name sortKey="Bonnycastle, Lori L" sort="Bonnycastle, Lori L" uniqKey="Bonnycastle L" first="Lori L." last="Bonnycastle">Lori L. Bonnycastle</name><affiliation><nlm:aff id="A91">Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Brambilla, Paolo" sort="Brambilla, Paolo" uniqKey="Brambilla P" first="Paolo" last="Brambilla">Paolo Brambilla</name><affiliation><nlm:aff id="A92">Dipartimento di Medicina Sperimentale. Università degli Studi Milano-Bicocca, Monza, Italy</nlm:aff></affiliation></author><author><name sortKey="Bruinenberg, Marcel" sort="Bruinenberg, Marcel" uniqKey="Bruinenberg M" first="Marcel" last="Bruinenberg">Marcel Bruinenberg</name><affiliation><nlm:aff id="A82">LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="A93">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</nlm:aff></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name><affiliation><nlm:aff id="A70">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts 02215, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A94">Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Chines, Peter S" sort="Chines, Peter S" uniqKey="Chines P" first="Peter S." last="Chines">Peter S. Chines</name><affiliation><nlm:aff id="A91">Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Collins, Francis S" sort="Collins, Francis S" uniqKey="Collins F" first="Francis S." last="Collins">Francis S. Collins</name><affiliation><nlm:aff id="A91">Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Connell, John M" sort="Connell, John M" uniqKey="Connell J" first="John M." last="Connell">John M. Connell</name><affiliation><nlm:aff id="A95">British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, G12 8TA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A96">University of Dundee, Ninewells Hospital &Medical School, Dundee, DD1 9SY, UK</nlm:aff></affiliation></author><author><name sortKey="Cookson, William" sort="Cookson, William" uniqKey="Cookson W" first="William" last="Cookson">William Cookson</name><affiliation><nlm:aff id="A97">National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK</nlm:aff></affiliation></author><author><name sortKey="De Faire, Ulf" sort="De Faire, Ulf" uniqKey="De Faire U" first="Ulf" last="De Faire">Ulf De Faire</name><affiliation><nlm:aff id="A98">Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="De Vegt, Femmie" sort="De Vegt, Femmie" uniqKey="De Vegt F" first="Femmie" last="De Vegt">Femmie De Vegt</name><affiliation><nlm:aff id="A99">Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Dei, Mariano" sort="Dei, Mariano" uniqKey="Dei M" first="Mariano" last="Dei">Mariano Dei</name><affiliation><nlm:aff id="A100">Istituto di Ricerca Genetica e Biomedicadel del CNR, Monserrato, 09042, Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Dimitriou, Maria" sort="Dimitriou, Maria" uniqKey="Dimitriou M" first="Maria" last="Dimitriou">Maria Dimitriou</name><affiliation><nlm:aff id="A101">Department of Dietetics-Nutrition, Harokopio University, 70 El. Venizelou Str, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Edkins, Sarah" sort="Edkins, Sarah" uniqKey="Edkins S" first="Sarah" last="Edkins">Sarah Edkins</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Estrada, Karol" sort="Estrada, Karol" uniqKey="Estrada K" first="Karol" last="Estrada">Karol Estrada</name><affiliation><nlm:aff id="A35">Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A60">Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name><affiliation><nlm:aff id="A66">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Farrall, Martin" sort="Farrall, Martin" uniqKey="Farrall M" first="Martin" last="Farrall">Martin Farrall</name><affiliation><nlm:aff id="A41">Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Oxford, OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Ferrario, Marco M" sort="Ferrario, Marco M" uniqKey="Ferrario M" first="Marco M." last="Ferrario">Marco M. Ferrario</name><affiliation><nlm:aff id="A102">Epidemiology and Preventive Medicine Research Center, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy</nlm:aff></affiliation></author><author><name sortKey="Ferrieres, Jean" sort="Ferrieres, Jean" uniqKey="Ferrieres J" first="Jean" last="Ferrières">Jean Ferrières</name><affiliation><nlm:aff id="A103">Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, France</nlm:aff></affiliation></author><author><name sortKey="Franke, Lude" sort="Franke, Lude" uniqKey="Franke L" first="Lude" last="Franke">Lude Franke</name><affiliation><nlm:aff id="A82">LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A104">Department of Genetics, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Frau, Francesca" sort="Frau, Francesca" uniqKey="Frau F" first="Francesca" last="Frau">Francesca Frau</name><affiliation><nlm:aff id="A105">University of Milan, Department of Health Sciences, Ospedale San Paolo, 20139 Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Gejman, Pablo V" sort="Gejman, Pablo V" uniqKey="Gejman P" first="Pablo V." last="Gejman">Pablo V. Gejman</name><affiliation><nlm:aff id="A106">University of Chicago, Chicago, Illinois 60637, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A107">Northshore University HealthSystem, Evanston, Illinois 60201, USA</nlm:aff></affiliation></author><author><name sortKey="Grallert, Harald" sort="Grallert, Harald" uniqKey="Grallert H" first="Harald" last="Grallert">Harald Grallert</name><affiliation><nlm:aff id="A108">Research Unit for Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name><affiliation><nlm:aff id="A3">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="A74">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A75">Department of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Hall, Alistair S" sort="Hall, Alistair S" uniqKey="Hall A" first="Alistair S." last="Hall">Alistair S. Hall</name><affiliation><nlm:aff id="A109">Division of Cardiovascular and Neuronal Remodelling, Multidisciplinary Cardiovascular Research Centre, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, UK</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="A3">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation><nlm:aff id="A110">Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="A43">MRC Human Genetics Unit, MRC Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, UK</nlm:aff></affiliation></author><author><name sortKey="Heard Costa, Nancy L" sort="Heard Costa, Nancy L" uniqKey="Heard Costa N" first="Nancy L." last="Heard-Costa">Nancy L. Heard-Costa</name><affiliation><nlm:aff id="A111">Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Heath, Andrew C" sort="Heath, Andrew C" uniqKey="Heath A" first="Andrew C." last="Heath">Andrew C. Heath</name><affiliation><nlm:aff id="A112">Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63108, USA</nlm:aff></affiliation></author><author><name sortKey="Hebebrand, Johannes" sort="Hebebrand, Johannes" uniqKey="Hebebrand J" first="Johannes" last="Hebebrand">Johannes Hebebrand</name><affiliation><nlm:aff id="A113">Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, 45147 Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name><affiliation><nlm:aff id="A77">Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, 17487 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B." last="Hu">Frank B. Hu</name><affiliation><nlm:aff id="A23">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Hunt, Sarah E" sort="Hunt, Sarah E" uniqKey="Hunt S" first="Sarah E." last="Hunt">Sarah E. Hunt</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><affiliation><nlm:aff id="A114">Centre For Paediatric Epidemiolgy and Biostatistics/MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Iribarren, Carlos" sort="Iribarren, Carlos" uniqKey="Iribarren C" first="Carlos" last="Iribarren">Carlos Iribarren</name><affiliation><nlm:aff id="A115">Division of Research, Kaiser Permanente Northern California, Oakland, California 94612, USA</nlm:aff></affiliation></author><author><name sortKey="Jacobs, Kevin B" sort="Jacobs, Kevin B" uniqKey="Jacobs K" first="Kevin B." last="Jacobs">Kevin B. Jacobs</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A116">Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA</nlm:aff></affiliation></author><author><name sortKey="Jansson, John Olov" sort="Jansson, John Olov" uniqKey="Jansson J" first="John-Olov" last="Jansson">John-Olov Jansson</name><affiliation><nlm:aff id="A117">Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Jula, Antti" sort="Jula, Antti" uniqKey="Jula A" first="Antti" last="Jula">Antti Jula</name><affiliation><nlm:aff id="A118">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Population Studies Unit, 20720 Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:aff id="A119">Department of Clinical Physiology, University of Tampere and Tampere University Hospital, 33520 Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Kathiresan, Sekar" sort="Kathiresan, Sekar" uniqKey="Kathiresan S" first="Sekar" last="Kathiresan">Sekar Kathiresan</name><affiliation><nlm:aff id="A120">Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A121">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A122">Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation></author><author><name sortKey="Kee, Frank" sort="Kee, Frank" uniqKey="Kee F" first="Frank" last="Kee">Frank Kee</name><affiliation><nlm:aff id="A123">UKCRC Centre of Excellence for Public Health (NI) Queens University, Belfast</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:aff id="A124">Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge CB2 2SR, UK</nlm:aff></affiliation></author><author><name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name><affiliation><nlm:aff id="A125">Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, UK</nlm:aff></affiliation></author><author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name><affiliation><nlm:aff id="A126">Department of Internal Medicine II – Cardiology, University of Ulm Medical Center, Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Kraja, Aldi T" sort="Kraja, Aldi T" uniqKey="Kraja A" first="Aldi T." last="Kraja">Aldi T. Kraja</name><affiliation><nlm:aff id="A7">Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name><affiliation><nlm:aff id="A125">Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, UK</nlm:aff></affiliation></author><author><name sortKey="Kuulasmaa, Kari" sort="Kuulasmaa, Kari" uniqKey="Kuulasmaa K" first="Kari" last="Kuulasmaa">Kari Kuulasmaa</name><affiliation><nlm:aff id="A127">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, 00271, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kuusisto, Johanna" sort="Kuusisto, Johanna" uniqKey="Kuusisto J" first="Johanna" last="Kuusisto">Johanna Kuusisto</name><affiliation><nlm:aff id="A128">Department of Medicine, University of Eastern Finland, Kuopio Campus and Kuopio University Hospital, 70210 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Laitinen, Jaana H" sort="Laitinen, Jaana H" uniqKey="Laitinen J" first="Jaana H." last="Laitinen">Jaana H. Laitinen</name><affiliation><nlm:aff id="A129">Finnish Institute of Occupational Health, 90220 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Lakka, Timo A" sort="Lakka, Timo A" uniqKey="Lakka T" first="Timo A." last="Lakka">Timo A. Lakka</name><affiliation><nlm:aff id="A86">Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A130">Kuopio Research Institute of Exercise Medicine, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation><nlm:aff id="A11">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A125">Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, UK</nlm:aff></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><affiliation><nlm:aff id="A131">Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation><nlm:aff id="A132">Department of Medical Sciences, Uppsala University, Akademiska sjukhuset, 751 85 Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Jaana" sort="Lindstrom, Jaana" uniqKey="Lindstrom J" first="Jaana" last="Lindström">Jaana Lindström</name><affiliation><nlm:aff id="A133">National Institute for Health and Welfare, Diabetes Prevention Unit, 00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:aff id="A134">Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore</nlm:aff></affiliation></author><author><name sortKey="Liuzzi, Antonio" sort="Liuzzi, Antonio" uniqKey="Liuzzi A" first="Antonio" last="Liuzzi">Antonio Liuzzi</name><affiliation><nlm:aff id="A135">Department of Internal Medicine, Istituto Auxologico Italiano, Verbania, Italy</nlm:aff></affiliation></author><author><name sortKey="Lokki, Marja Liisa" sort="Lokki, Marja Liisa" uniqKey="Lokki M" first="Marja-Liisa" last="Lokki">Marja-Liisa Lokki</name><affiliation><nlm:aff id="A136">Transplantation Laboratory, Haartman Institute, University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Lorentzon, Mattias" sort="Lorentzon, Mattias" uniqKey="Lorentzon M" first="Mattias" last="Lorentzon">Mattias Lorentzon</name><affiliation><nlm:aff id="A83">Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Madden, Pamela A" sort="Madden, Pamela A" uniqKey="Madden P" first="Pamela A." last="Madden">Pamela A. Madden</name><affiliation><nlm:aff id="A112">Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63108, USA</nlm:aff></affiliation></author><author><name sortKey="Magnusson, Patrik K" sort="Magnusson, Patrik K" uniqKey="Magnusson P" first="Patrik K." last="Magnusson">Patrik K. Magnusson</name><affiliation><nlm:aff id="A3">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Manunta, Paolo" sort="Manunta, Paolo" uniqKey="Manunta P" first="Paolo" last="Manunta">Paolo Manunta</name><affiliation><nlm:aff id="A137">Università Vita-Salute San Raffaele, Chair of Nephrology San Raffaele Scientific Institute, OU Nephrology and Dialysis, 20132 Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Marek, Diana" sort="Marek, Diana" uniqKey="Marek D" first="Diana" last="Marek">Diana Marek</name><affiliation><nlm:aff id="A52">Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A53">Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="M Rz, Winfried" sort="M Rz, Winfried" uniqKey="M Rz W" first="Winfried" last="M Rz">Winfried M Rz</name><affiliation><nlm:aff id="A50">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A138">Synlab Academy, Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Mateo Leach, Irene" sort="Mateo Leach, Irene" uniqKey="Mateo Leach I" first="Irene" last="Mateo Leach">Irene Mateo Leach</name><affiliation><nlm:aff id="A139">Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name><affiliation><nlm:aff id="A140">Departments of Biostatistics, University of Washington, Seattle, Washington 98195, USA</nlm:aff></affiliation></author><author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name><affiliation><nlm:aff id="A33">Queensland Institute of Medical Research, Brisbane 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Mihailov, Evelin" sort="Mihailov, Evelin" uniqKey="Mihailov E" first="Evelin" last="Mihailov">Evelin Mihailov</name><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Milani, Lili" sort="Milani, Lili" uniqKey="Milani L" first="Lili" last="Milani">Lili Milani</name><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</nlm:aff></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation><nlm:aff id="A33">Queensland Institute of Medical Research, Brisbane 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Mooser, Vincent" sort="Mooser, Vincent" uniqKey="Mooser V" first="Vincent" last="Mooser">Vincent Mooser</name><affiliation><nlm:aff id="A141">Genetics Division, GlaxoSmithKline, King of Prussia, Pennsylvania 19406, USA</nlm:aff></affiliation></author><author><name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W." last="Mühleisen">Thomas W. Mühleisen</name><affiliation><nlm:aff id="A142">Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A143">Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Munroe, Patricia B" sort="Munroe, Patricia B" uniqKey="Munroe P" first="Patricia B." last="Munroe">Patricia B. Munroe</name><affiliation><nlm:aff id="A47">Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Musk, Arthur W" sort="Musk, Arthur W" uniqKey="Musk A" first="Arthur W." last="Musk">Arthur W. Musk</name><affiliation><nlm:aff id="A144">School of Population Health, The University of Western Australia, Nedlands WA 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A145">Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Australia, 6009</nlm:aff></affiliation><affiliation><nlm:aff id="A146">Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="Narisu, Narisu" sort="Narisu, Narisu" uniqKey="Narisu N" first="Narisu" last="Narisu">Narisu Narisu</name><affiliation><nlm:aff id="A91">Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name><affiliation><nlm:aff id="A147">Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen</nlm:aff></affiliation></author><author><name sortKey="Nicholson, George" sort="Nicholson, George" uniqKey="Nicholson G" first="George" last="Nicholson">George Nicholson</name><affiliation><nlm:aff id="A148">MRC Harwell, Harwell, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A149">Department of Statistics, University of Oxford, Oxford OX1 3TG, UK</nlm:aff></affiliation></author><author><name sortKey="Nohr, Ellen A" sort="Nohr, Ellen A" uniqKey="Nohr E" first="Ellen A." last="Nohr">Ellen A. Nohr</name><affiliation><nlm:aff id="A150">Department of Public Health, Section of Epidemiology, Aarhus University, Denmark</nlm:aff></affiliation></author><author><name sortKey="Ong, Ken K" sort="Ong, Ken K" uniqKey="Ong K" first="Ken K." last="Ong">Ken K. Ong</name><affiliation><nlm:aff id="A11">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A151">MRC Unit for Lifelong Health & Ageing, London, UK</nlm:aff></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name><affiliation><nlm:aff id="A61">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation><affiliation><nlm:aff id="A152">Department of Clinical Genetics, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A153">Centre for Medical Systems Biology & Netherlands Consortium on Healthy Aging, Leiden, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Palmer, Colin N A" sort="Palmer, Colin N A" uniqKey="Palmer C" first="Colin N. A." last="Palmer">Colin N. A. Palmer</name><affiliation><nlm:aff id="A154">Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School. Dundee, DD1 9SY</nlm:aff></affiliation></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Peden, John F" sort="Peden, John F" uniqKey="Peden J" first="John F." last="Peden">John F. Peden</name><affiliation><nlm:aff id="A155">Illumina Inc. Cambridge</nlm:aff></affiliation></author><author><name sortKey="Pedersen, Nancy" sort="Pedersen, Nancy" uniqKey="Pedersen N" first="Nancy" last="Pedersen">Nancy Pedersen</name><affiliation><nlm:aff id="A3">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name><affiliation><nlm:aff id="A108">Research Unit for Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A156">Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A157">Munich Heart Alliance, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation><nlm:aff id="A158">Faculty of Medicine, University of Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation><nlm:aff id="A110">Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A159">National Institute for Health and Welfare, 90101 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><affiliation><nlm:aff id="A160">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, 39100, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A161">Department of Neurology, General Central Hospital, Bolzano, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A162">Department of Neurology, University of Lübeck, Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A163">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Putter, Carolin" sort="Putter, Carolin" uniqKey="Putter C" first="Carolin" last="Pütter">Carolin Pütter</name><affiliation><nlm:aff id="A67">Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital of Essen, University of Duisburg-Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Radhakrishnan, Aparna" sort="Radhakrishnan, Aparna" uniqKey="Radhakrishnan A" first="Aparna" last="Radhakrishnan">Aparna Radhakrishnan</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A164">Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A165">NHS Blood and Transplant, Cambridge Centre, Cambridge, CB2 0PT, UK</nlm:aff></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation><nlm:aff id="A166">Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520 Turku, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A167">The Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, 20520 Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Rendon, Augusto" sort="Rendon, Augusto" uniqKey="Rendon A" first="Augusto" last="Rendon">Augusto Rendon</name><affiliation><nlm:aff id="A87">NIHR Cambridge Biomedical Research Centre, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A164">Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A165">NHS Blood and Transplant, Cambridge Centre, Cambridge, CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A168">MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="A35">Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A60">Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="A93">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</nlm:aff></affiliation></author><author><name sortKey="Saaristo, Timo E" sort="Saaristo, Timo E" uniqKey="Saaristo T" first="Timo E." last="Saaristo">Timo E. Saaristo</name><affiliation><nlm:aff id="A169">Finnish Diabetes Association, Kirjoniementie 15, 33680, Tampere, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A170">Pirkanmaa Hospital District, Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Sambrook, Jennifer G" sort="Sambrook, Jennifer G" uniqKey="Sambrook J" first="Jennifer G." last="Sambrook">Jennifer G. Sambrook</name><affiliation><nlm:aff id="A164">Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A165">NHS Blood and Transplant, Cambridge Centre, Cambridge, CB2 0PT, UK</nlm:aff></affiliation></author><author><name sortKey="Sanders, Alan R" sort="Sanders, Alan R" uniqKey="Sanders A" first="Alan R." last="Sanders">Alan R. Sanders</name><affiliation><nlm:aff id="A106">University of Chicago, Chicago, Illinois 60637, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A107">Northshore University HealthSystem, Evanston, Illinois 60201, USA</nlm:aff></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation><nlm:aff id="A100">Istituto di Ricerca Genetica e Biomedicadel del CNR, Monserrato, 09042, Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Saramies, Jouko" sort="Saramies, Jouko" uniqKey="Saramies J" first="Jouko" last="Saramies">Jouko Saramies</name><affiliation><nlm:aff id="A171">South Karelia Central Hospital, 53130 Lappeenranta, Finland</nlm:aff></affiliation></author><author><name sortKey="Schipf, Sabine" sort="Schipf, Sabine" uniqKey="Schipf S" first="Sabine" last="Schipf">Sabine Schipf</name><affiliation><nlm:aff id="A172">Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Schreiber, Stefan" sort="Schreiber, Stefan" uniqKey="Schreiber S" first="Stefan" last="Schreiber">Stefan Schreiber</name><affiliation><nlm:aff id="A173">Institute for Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Schunkert, Heribert" sort="Schunkert, Heribert" uniqKey="Schunkert H" first="Heribert" last="Schunkert">Heribert Schunkert</name><affiliation><nlm:aff id="A69">Universität zu Lübeck, Medizinische Klinik II, 23538 Lübeck, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A174">Deutsches Zentrum für Herz-Kreislaufforschung e. V. (DZHK), Universität zu Lübeck, 23538 Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Shin, So Youn" sort="Shin, So Youn" uniqKey="Shin S" first="So-Youn" last="Shin">So-Youn Shin</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Signorini, Stefano" sort="Signorini, Stefano" uniqKey="Signorini S" first="Stefano" last="Signorini">Stefano Signorini</name><affiliation><nlm:aff id="A175">Azienda ospedaliera di Desio e Vimercate, Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Sinisalo, Juha" sort="Sinisalo, Juha" uniqKey="Sinisalo J" first="Juha" last="Sinisalo">Juha Sinisalo</name><affiliation><nlm:aff id="A176">Division of Cardiology, Cardiovascular Laboratory, Helsinki University Central Hospital, 00029 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Skrobek, Boris" sort="Skrobek, Boris" uniqKey="Skrobek B" first="Boris" last="Skrobek">Boris Skrobek</name><affiliation><nlm:aff id="A55">University Lille Nord de France, 59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A56">CNRS UMR8199-IBL-Institut Pasteur de Lille, F-59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A58">Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Stan Kova, Alena" sort="Stan Kova, Alena" uniqKey="Stan Kova A" first="Alena" last="Stan Ková">Alena Stan Ková</name><affiliation><nlm:aff id="A177">University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Stark, Klaus" sort="Stark, Klaus" uniqKey="Stark K" first="Klaus" last="Stark">Klaus Stark</name><affiliation><nlm:aff id="A178">Klinik und Poliklinik für Innere Medizin II, Universitätklinikum Regensburg, 93053 Regensburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Stephens, Jonathan C" sort="Stephens, Jonathan C" uniqKey="Stephens J" first="Jonathan C." last="Stephens">Jonathan C. Stephens</name><affiliation><nlm:aff id="A164">Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A165">NHS Blood and Transplant, Cambridge Centre, Cambridge, CB2 0PT, UK</nlm:aff></affiliation></author><author><name sortKey="Stirrups, Kathleen" sort="Stirrups, Kathleen" uniqKey="Stirrups K" first="Kathleen" last="Stirrups">Kathleen Stirrups</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Stolk, Ronald P" sort="Stolk, Ronald P" uniqKey="Stolk R" first="Ronald P." last="Stolk">Ronald P. Stolk</name><affiliation><nlm:aff id="A65">Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A82">LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation><nlm:aff id="A179">Department of Medicine, University of Leipzig, 04103 Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A180">University of Leipzig, IFB Adiposity Diseases, Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Swift, Amy J" sort="Swift, Amy J" uniqKey="Swift A" first="Amy J." last="Swift">Amy J. Swift</name><affiliation><nlm:aff id="A91">Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Theodoraki, Eirini V" sort="Theodoraki, Eirini V" uniqKey="Theodoraki E" first="Eirini V." last="Theodoraki">Eirini V. Theodoraki</name><affiliation><nlm:aff id="A101">Department of Dietetics-Nutrition, Harokopio University, 70 El. Venizelou Str, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Thorand, Barbara" sort="Thorand, Barbara" uniqKey="Thorand B" first="Barbara" last="Thorand">Barbara Thorand</name><affiliation><nlm:aff id="A156">Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Tregouet, David Alexandre" sort="Tregouet, David Alexandre" uniqKey="Tregouet D" first="David-Alexandre" last="Tregouet">David-Alexandre Tregouet</name><affiliation><nlm:aff id="A181">INSERM UMR_S 937, ICAN Institute, Pierre et Marie Curie Medical School, Paris 75013, France</nlm:aff></affiliation></author><author><name sortKey="Tremoli, Elena" sort="Tremoli, Elena" uniqKey="Tremoli E" first="Elena" last="Tremoli">Elena Tremoli</name><affiliation><nlm:aff id="A182">Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Centro Cardiologico Monzino, IRCCS, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Van Der Klauw, Melanie M" sort="Van Der Klauw, Melanie M" uniqKey="Van Der Klauw M" first="Melanie M." last="Van Der Klauw">Melanie M. Van Der Klauw</name><affiliation><nlm:aff id="A81">Department of Endocrinology, University Medical Center Groningen, University of Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A82">LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Meurs, Joyce B J" sort="Van Meurs, Joyce B J" uniqKey="Van Meurs J" first="Joyce B. J." last="Van Meurs">Joyce B. J. Van Meurs</name><affiliation><nlm:aff id="A35">Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A60">Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Vermeulen, Sita H" sort="Vermeulen, Sita H" uniqKey="Vermeulen S" first="Sita H." last="Vermeulen">Sita H. Vermeulen</name><affiliation><nlm:aff id="A99">Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A183">Department of Human Genetics, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Viikari, Jorma" sort="Viikari, Jorma" uniqKey="Viikari J" first="Jorma" last="Viikari">Jorma Viikari</name><affiliation><nlm:aff id="A184">Department of Medicine, University of Turku and Turku University Hospital, 20520 Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation><nlm:aff id="A127">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, 00271, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation><nlm:aff id="A43">MRC Human Genetics Unit, MRC Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, UK</nlm:aff></affiliation></author><author><name sortKey="Waeber, Gerard" sort="Waeber, Gerard" uniqKey="Waeber G" first="Gérard" last="Waeber">Gérard Waeber</name><affiliation><nlm:aff id="A185">Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, 1011 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A116">Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA</nlm:aff></affiliation></author><author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widén">Elisabeth Widén</name><affiliation><nlm:aff id="A68">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name><affiliation><nlm:aff id="A93">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</nlm:aff></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation><nlm:aff id="A42">Department of Biological Psychology, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Winkelmann, Bernhard R" sort="Winkelmann, Bernhard R" uniqKey="Winkelmann B" first="Bernhard R." last="Winkelmann">Bernhard R. Winkelmann</name><affiliation><nlm:aff id="A186">Cardiology Group, Frankfurt-Sachsenhausen, Germany</nlm:aff></affiliation></author><author><name sortKey="Witteman, Jacqueline C M" sort="Witteman, Jacqueline C M" uniqKey="Witteman J" first="Jacqueline C. M." last="Witteman">Jacqueline C. M. Witteman</name><affiliation><nlm:aff id="A35">Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Wolffenbuttel, Bruce H R" sort="Wolffenbuttel, Bruce H R" uniqKey="Wolffenbuttel B" first="Bruce H. R." last="Wolffenbuttel">Bruce H. R. Wolffenbuttel</name><affiliation><nlm:aff id="A81">Department of Endocrinology, University Medical Center Groningen, University of Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A82">LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wong, Andrew" sort="Wong, Andrew" uniqKey="Wong A" first="Andrew" last="Wong">Andrew Wong</name><affiliation><nlm:aff id="A151">MRC Unit for Lifelong Health & Ageing, London, UK</nlm:aff></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name><affiliation><nlm:aff id="A43">MRC Human Genetics Unit, MRC Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, UK</nlm:aff></affiliation></author><author><name sortKey="Zillikens, M Carola" sort="Zillikens, M Carola" uniqKey="Zillikens M" first="M. Carola" last="Zillikens">M. Carola Zillikens</name><affiliation><nlm:aff id="A60">Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation><nlm:aff id="A187">Institut Pasteur de Lille, INSERM U744, Université Lille Nord de France, F-59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Boehm, Bernhard O" sort="Boehm, Bernhard O" uniqKey="Boehm B" first="Bernhard O." last="Boehm">Bernhard O. Boehm</name><affiliation><nlm:aff id="A188">Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation><nlm:aff id="A189">Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:aff id="A42">Department of Biological Psychology, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Caulfield, Mark J" sort="Caulfield, Mark J" uniqKey="Caulfield M" first="Mark J." last="Caulfield">Mark J. Caulfield</name><affiliation><nlm:aff id="A47">Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Cupples, L Adrienne" sort="Cupples, L Adrienne" uniqKey="Cupples L" first="L. Adrienne" last="Cupples">L. Adrienne Cupples</name><affiliation><nlm:aff id="A64">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Cusi, Daniele" sort="Cusi, Daniele" uniqKey="Cusi D" first="Daniele" last="Cusi">Daniele Cusi</name><affiliation><nlm:aff id="A105">University of Milan, Department of Health Sciences, Ospedale San Paolo, 20139 Milano, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A190">Fondazione Filarete, Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Dedoussis, George V" sort="Dedoussis, George V" uniqKey="Dedoussis G" first="George V." last="Dedoussis">George V. Dedoussis</name><affiliation><nlm:aff id="A101">Department of Dietetics-Nutrition, Harokopio University, 70 El. Venizelou Str, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Erdmann, Jeanette" sort="Erdmann, Jeanette" uniqKey="Erdmann J" first="Jeanette" last="Erdmann">Jeanette Erdmann</name><affiliation><nlm:aff id="A69">Universität zu Lübeck, Medizinische Klinik II, 23538 Lübeck, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A174">Deutsches Zentrum für Herz-Kreislaufforschung e. V. (DZHK), Universität zu Lübeck, 23538 Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G." last="Eriksson">Johan G. Eriksson</name><affiliation><nlm:aff id="A191">Department of General Practice and Primary health Care, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A192">National Institute for Health and Welfare, 00271 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A193">Helsinki University Central Hospital, Unit of General Practice, 00280 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Franks, Paul W" sort="Franks, Paul W" uniqKey="Franks P" first="Paul W." last="Franks">Paul W. Franks</name><affiliation><nlm:aff id="A71">Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Lund University, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Department of Public Health & Clinical Medicine, Umeå University, Umeå, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A194">Department of Nutrition, Harvard School of Public Health, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="A55">University Lille Nord de France, 59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A56">CNRS UMR8199-IBL-Institut Pasteur de Lille, F-59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A195">Department of Genomics of Common Disease, School of Public Health, Imperial College London, W12 0NN, London, UK</nlm:aff></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation><nlm:aff id="A34">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation><nlm:aff id="A45">Department of Immunology, Genetics and Pathology, Uppsala University, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name><affiliation><nlm:aff id="A76">Atherosclerosis Research Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="A131">Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Hengstenberg, Christian" sort="Hengstenberg, Christian" uniqKey="Hengstenberg C" first="Christian" last="Hengstenberg">Christian Hengstenberg</name><affiliation><nlm:aff id="A178">Klinik und Poliklinik für Innere Medizin II, Universitätklinikum Regensburg, 93053 Regensburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A." last="Hicks">Andrew A. Hicks</name><affiliation><nlm:aff id="A160">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, 39100, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Hingorani, Aroon" sort="Hingorani, Aroon" uniqKey="Hingorani A" first="Aroon" last="Hingorani">Aroon Hingorani</name><affiliation><nlm:aff id="A125">Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, UK</nlm:aff></affiliation></author><author><name sortKey="Hinney, Anke" sort="Hinney, Anke" uniqKey="Hinney A" first="Anke" last="Hinney">Anke Hinney</name><affiliation><nlm:aff id="A113">Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, 45147 Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A35">Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Hovingh, Kees G" sort="Hovingh, Kees G" uniqKey="Hovingh K" first="Kees G." last="Hovingh">Kees G. Hovingh</name><affiliation><nlm:aff id="A78">Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hveem, Kristian" sort="Hveem, Kristian" uniqKey="Hveem K" first="Kristian" last="Hveem">Kristian Hveem</name><affiliation><nlm:aff id="A196">HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway</nlm:aff></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation><nlm:aff id="A108">Research Unit for Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A197">Hannover Unified Biobank, Hannover Medical School, 30625 Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation><nlm:aff id="A159">National Institute for Health and Welfare, 90101 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A198">Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, W2 1PG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A199">Institute of Health Sciences, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A200">Biocenter Oulu, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Jockel, Karl Heinz" sort="Jockel, Karl Heinz" uniqKey="Jockel K" first="Karl-Heinz" last="Jöckel">Karl-Heinz Jöckel</name><affiliation><nlm:aff id="A67">Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital of Essen, University of Duisburg-Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Keinanen Kiukaanniemi, Sirkka M" sort="Keinanen Kiukaanniemi, Sirkka M" uniqKey="Keinanen Kiukaanniemi S" first="Sirkka M." last="Keinanen-Kiukaanniemi">Sirkka M. Keinanen-Kiukaanniemi</name><affiliation><nlm:aff id="A199">Institute of Health Sciences, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A201">Unit of General Practice, Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Kiemeney, Lambertus A" sort="Kiemeney, Lambertus A" uniqKey="Kiemeney L" first="Lambertus A." last="Kiemeney">Lambertus A. Kiemeney</name><affiliation><nlm:aff id="A99">Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A202">Department of Urology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A203">Comprehensive Cancer Center East, 6501 BG Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kuh, Diana" sort="Kuh, Diana" uniqKey="Kuh D" first="Diana" last="Kuh">Diana Kuh</name><affiliation><nlm:aff id="A151">MRC Unit for Lifelong Health & Ageing, London, UK</nlm:aff></affiliation></author><author><name sortKey="Laakso, Markku" sort="Laakso, Markku" uniqKey="Laakso M" first="Markku" last="Laakso">Markku Laakso</name><affiliation><nlm:aff id="A128">Department of Medicine, University of Eastern Finland, Kuopio Campus and Kuopio University Hospital, 70210 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:aff id="A204">Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere and Tampere University Hospital, 33520 Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Levinson, Douglas F" sort="Levinson, Douglas F" uniqKey="Levinson D" first="Douglas F." last="Levinson">Douglas F. Levinson</name><affiliation><nlm:aff id="A205">Stanford University School of Medicine, Stanford, California 93405, USA</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="A33">Queensland Institute of Medical Research, Brisbane 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Morris, Andrew D" sort="Morris, Andrew D" uniqKey="Morris A" first="Andrew D." last="Morris">Andrew D. Morris</name><affiliation><nlm:aff id="A154">Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School. Dundee, DD1 9SY</nlm:aff></affiliation></author><author><name sortKey="Nieminen, Markku S" sort="Nieminen, Markku S" uniqKey="Nieminen M" first="Markku S." last="Nieminen">Markku S. Nieminen</name><affiliation><nlm:aff id="A176">Division of Cardiology, Cardiovascular Laboratory, Helsinki University Central Hospital, 00029 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Nj Lstad, Inger" sort="Nj Lstad, Inger" uniqKey="Nj Lstad I" first="Inger" last="Nj Lstad">Inger Nj Lstad</name><affiliation><nlm:aff id="A206">Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A207">Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway</nlm:aff></affiliation></author><author><name sortKey="Ohlsson, Claes" sort="Ohlsson, Claes" uniqKey="Ohlsson C" first="Claes" last="Ohlsson">Claes Ohlsson</name><affiliation><nlm:aff id="A83">Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Oldehinkel, Albertine J" sort="Oldehinkel, Albertine J" uniqKey="Oldehinkel A" first="Albertine J." last="Oldehinkel">Albertine J. Oldehinkel</name><affiliation><nlm:aff id="A208">Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Ouwehand, Willem H" sort="Ouwehand, Willem H" uniqKey="Ouwehand W" first="Willem H." last="Ouwehand">Willem H. Ouwehand</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A87">NIHR Cambridge Biomedical Research Centre, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A164">Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A165">NHS Blood and Transplant, Cambridge Centre, Cambridge, CB2 0PT, UK</nlm:aff></affiliation></author><author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J." last="Palmer">Lyle J. Palmer</name><affiliation><nlm:aff id="A36">Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research. Toronto, Canada, M5G 1L7</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Toronto, Canada, M5G 1X5</nlm:aff></affiliation></author><author><name sortKey="Penninx, Brenda" sort="Penninx, Brenda" uniqKey="Penninx B" first="Brenda" last="Penninx">Brenda Penninx</name><affiliation><nlm:aff id="A209">Department of Psychiatry, University Medical Centre Groningen, 9713 GZ Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Power, Chris" sort="Power, Chris" uniqKey="Power C" first="Chris" last="Power">Chris Power</name><affiliation><nlm:aff id="A114">Centre For Paediatric Epidemiolgy and Biostatistics/MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Province, Michael A" sort="Province, Michael A" uniqKey="Province M" first="Michael A." last="Province">Michael A. Province</name><affiliation><nlm:aff id="A7">Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name><affiliation><nlm:aff id="A57">Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A210">Departments of Epidemiology, Medicine and Health Services, University of Washington, Seattle, Washington 98195, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A211">Group Health Research Institute, Group Health, Seattle, Washington 98101, USA</nlm:aff></affiliation></author><author><name sortKey="Qi, Lu" sort="Qi, Lu" uniqKey="Qi L" first="Lu" last="Qi">Lu Qi</name><affiliation><nlm:aff id="A23">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Rauramaa, Rainer" sort="Rauramaa, Rainer" uniqKey="Rauramaa R" first="Rainer" last="Rauramaa">Rainer Rauramaa</name><affiliation><nlm:aff id="A130">Kuopio Research Institute of Exercise Medicine, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A212">Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name><affiliation><nlm:aff id="A70">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts 02215, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A94">Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Ripatti, Samuli" sort="Ripatti, Samuli" uniqKey="Ripatti S" first="Samuli" last="Ripatti">Samuli Ripatti</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A40">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation><nlm:aff id="A127">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, 00271, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name><affiliation><nlm:aff id="A213">Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, LE3 9QP, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A214">Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, LE3 9QP, UK</nlm:aff></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation><nlm:aff id="A65">Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A82">LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="S Rensen, Thorkild I A" sort="S Rensen, Thorkild I A" uniqKey="S Rensen T" first="Thorkild I. A." last="S Rensen">Thorkild I. A. S Rensen</name><affiliation><nlm:aff id="A215">Institute of Preventive Medicine, Bispebjerg University Hospital, Copenhagen, and Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D." last="Spector">Timothy D. Spector</name><affiliation><nlm:aff id="A58">Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><nlm:aff id="A31">deCODE Genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A216">Faculty of Medicine, University of Iceland, 101 Reykjavík, Iceland</nlm:aff></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name><affiliation><nlm:aff id="A179">Department of Medicine, University of Leipzig, 04103 Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A180">University of Leipzig, IFB Adiposity Diseases, Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Tuomilehto, Jaakko" sort="Tuomilehto, Jaakko" uniqKey="Tuomilehto J" first="Jaakko" last="Tuomilehto">Jaakko Tuomilehto</name><affiliation><nlm:aff id="A133">National Institute for Health and Welfare, Diabetes Prevention Unit, 00271 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A217">Red RECAVA Grupo RD06/0014/0015, Hospital Universitario La Paz, 28046 Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A218">Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria</nlm:aff></affiliation><affiliation><nlm:aff id="A219">South Ostrobothnia Central Hospital, 60220 Seinajoki, Finland</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G." last="Uitterlinden">André G. Uitterlinden</name><affiliation><nlm:aff id="A35">Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A60">Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Uusitupa, Matti" sort="Uusitupa, Matti" uniqKey="Uusitupa M" first="Matti" last="Uusitupa">Matti Uusitupa</name><affiliation><nlm:aff id="A220">Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A221">Research Unit, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation><nlm:aff id="A104">Department of Genetics, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A139">Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:aff id="A185">Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, 1011 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name><affiliation><nlm:aff id="A222">Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A11">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name><affiliation><nlm:aff id="A41">Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Oxford, OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H.-Erich" last="Wichmann">H.-Erich Wichmann</name><affiliation><nlm:aff id="A223">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A224">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A225">Klinikum Grosshadern, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="A93">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</nlm:aff></affiliation></author><author><name sortKey="Abecasis, Goncalo R" sort="Abecasis, Goncalo R" uniqKey="Abecasis G" first="Goncalo R." last="Abecasis">Goncalo R. Abecasis</name><affiliation><nlm:aff id="A14">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Assimes, Themistocles L" sort="Assimes, Themistocles L" uniqKey="Assimes T" first="Themistocles L." last="Assimes">Themistocles L. Assimes</name><affiliation><nlm:aff id="A226">Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA</nlm:aff></affiliation></author><author><name sortKey="Barroso, Ines" sort="Barroso, Ines" uniqKey="Barroso I" first="Inês" last="Barroso">Inês Barroso</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A227">University of Cambridge Metabolic Research Labs, Institute of Metabolic Science Addenbrooke’s Hospital, CB2 OQQ, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Boehnke, Michael" sort="Boehnke, Michael" uniqKey="Boehnke M" first="Michael" last="Boehnke">Michael Boehnke</name><affiliation><nlm:aff id="A14">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Borecki, Ingrid B" sort="Borecki, Ingrid B" uniqKey="Borecki I" first="Ingrid B." last="Borecki">Ingrid B. Borecki</name><affiliation><nlm:aff id="A7">Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S." last="Fox">Caroline S. Fox</name><affiliation><nlm:aff id="A228">Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham Heart Study, Framingham, Massachusetts 01702, USA</nlm:aff></affiliation></author><author><name sortKey="Frayling, Timothy" sort="Frayling, Timothy" uniqKey="Frayling T" first="Timothy" last="Frayling">Timothy Frayling</name><affiliation><nlm:aff id="A22">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, EX1 2LU, UK</nlm:aff></affiliation></author><author><name sortKey="Groop, Leif C" sort="Groop, Leif C" uniqKey="Groop L" first="Leif C." last="Groop">Leif C. Groop</name><affiliation><nlm:aff id="A229">Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, 20502 Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Haritunian, Talin" sort="Haritunian, Talin" uniqKey="Haritunian T" first="Talin" last="Haritunian">Talin Haritunian</name><affiliation><nlm:aff id="A230">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA</nlm:aff></affiliation></author><author><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M." last="Heid">Iris M. Heid</name><affiliation><nlm:aff id="A21">Public Health and Gender Studies, Institute of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A223">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hunter, David" sort="Hunter, David" uniqKey="Hunter D" first="David" last="Hunter">David Hunter</name><affiliation><nlm:aff id="A23">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Kaplan, Robert C" sort="Kaplan, Robert C" uniqKey="Kaplan R" first="Robert C." last="Kaplan">Robert C. Kaplan</name><affiliation><nlm:aff id="A231">Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA</nlm:aff></affiliation></author><author><name sortKey="Karpe, Fredrik" sort="Karpe, Fredrik" uniqKey="Karpe F" first="Fredrik" last="Karpe">Fredrik Karpe</name><affiliation><nlm:aff id="A163">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A232">Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Old Road Headington, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Moffatt, Miriam" sort="Moffatt, Miriam" uniqKey="Moffatt M" first="Miriam" last="Moffatt">Miriam Moffatt</name><affiliation><nlm:aff id="A97">National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK</nlm:aff></affiliation></author><author><name sortKey="Mohlke, Karen L" sort="Mohlke, Karen L" uniqKey="Mohlke K" first="Karen L." last="Mohlke">Karen L. Mohlke</name><affiliation><nlm:aff id="A10">Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA</nlm:aff></affiliation></author><author><name sortKey="O Onnell, Jeffrey R" sort="O Onnell, Jeffrey R" uniqKey="O Onnell J" first="Jeffrey R." last="O Onnell">Jeffrey R. O Onnell</name><affiliation><nlm:aff id="A233">Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</nlm:aff></affiliation></author><author><name sortKey="Pawitan, Yudi" sort="Pawitan, Yudi" uniqKey="Pawitan Y" first="Yudi" last="Pawitan">Yudi Pawitan</name><affiliation><nlm:aff id="A3">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Schadt, Eric E" sort="Schadt, Eric E" uniqKey="Schadt E" first="Eric E." last="Schadt">Eric E. Schadt</name><affiliation><nlm:aff id="A234">Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1498, New York, NY 10029-6574 USA</nlm:aff></affiliation><affiliation><nlm:aff id="A235">Institute of Genomics and Multiscale Biology, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1498, New York, NY 10029-6574 USA</nlm:aff></affiliation></author><author><name sortKey="Schlessinger, David" sort="Schlessinger, David" uniqKey="Schlessinger D" first="David" last="Schlessinger">David Schlessinger</name><affiliation><nlm:aff id="A236">Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224, USA</nlm:aff></affiliation></author><author><name sortKey="Steinthorsdottir, Valgerdur" sort="Steinthorsdottir, Valgerdur" uniqKey="Steinthorsdottir V" first="Valgerdur" last="Steinthorsdottir">Valgerdur Steinthorsdottir</name><affiliation><nlm:aff id="A31">deCODE Genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P." last="Strachan">David P. Strachan</name><affiliation><nlm:aff id="A237">Division of Population Health Sciences and Education, St George’s, University of London, London, SW17 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation><nlm:aff id="A31">deCODE Genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A216">Faculty of Medicine, University of Iceland, 101 Reykjavík, Iceland</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A35">Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation><affiliation><nlm:aff id="A238">Center of Medical Systems Biology, Leiden University Medical Center, 2333 ZC Leiden, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Visscher, Peter M" sort="Visscher, Peter M" uniqKey="Visscher P" first="Peter M." last="Visscher">Peter M. Visscher</name><affiliation><nlm:aff id="A26">The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A32">University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia</nlm:aff></affiliation></author><author><name sortKey="Di Blasio, Anna Maria" sort="Di Blasio, Anna Maria" uniqKey="Di Blasio A" first="Anna Maria" last="Di Blasio">Anna Maria Di Blasio</name><affiliation><nlm:aff id="A13">Molecular Biology Department, Istituto Auxologico Italiano, Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N." last="Hirschhorn">Joel N. Hirschhorn</name><affiliation><nlm:aff id="A15">Divisions of Genetics and Endocrinology and Center for Basic and Translational Obesity Research, Children’s Hospital, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Lindgren, Cecilia M" sort="Lindgren, Cecilia M" uniqKey="Lindgren C" first="Cecilia M." last="Lindgren">Cecilia M. Lindgren</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Morris, Andrew P" sort="Morris, Andrew P" uniqKey="Morris A" first="Andrew P." last="Morris">Andrew P. Morris</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Meyre, David" sort="Meyre, David" uniqKey="Meyre D" first="David" last="Meyre">David Meyre</name><affiliation><nlm:aff id="A55">University Lille Nord de France, 59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A56">CNRS UMR8199-IBL-Institut Pasteur de Lille, F-59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A239">Department of Clinical Epidemiology and Biostatistics, McMasterUniversity, Hamilton, Ontario L8S 4L8, Canada</nlm:aff></affiliation></author><author><name sortKey="Scherag, Andre" sort="Scherag, Andre" uniqKey="Scherag A" first="André" last="Scherag">André Scherag</name><affiliation><nlm:aff id="A67">Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital of Essen, University of Duisburg-Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I." last="Mccarthy">Mark I. Mccarthy</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A163">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A232">Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Old Road Headington, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Speliotes, Elizabeth K" sort="Speliotes, Elizabeth K" uniqKey="Speliotes E" first="Elizabeth K." last="Speliotes">Elizabeth K. Speliotes</name><affiliation><nlm:aff id="A240">Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A241">Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="North, Kari E" sort="North, Kari E" uniqKey="North K" first="Kari E." last="North">Kari E. North</name><affiliation><nlm:aff id="A8">Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, USA</nlm:aff></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J. F." last="Loos">Ruth J. F. Loos</name><affiliation><nlm:aff id="A11">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A242">The Charles Bronfman Institute of Personalized Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A243">The Mindich Child Health and Development Institute, Mount Sinai School of Medicine, New York, NY 10029, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A244">Department of Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA</nlm:aff></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation><nlm:aff id="A2">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23563607</idno><idno type="pmc">3973018</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973018</idno><idno type="RBID">PMC:3973018</idno><idno type="doi">10.1038/ng.2606</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">002E23</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E23</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture</title><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Gustafsson, Stefan" sort="Gustafsson, Stefan" uniqKey="Gustafsson S" first="Stefan" last="Gustafsson">Stefan Gustafsson</name><affiliation><nlm:aff id="A2">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</nlm:aff></affiliation></author><author><name sortKey="Ganna, Andrea" sort="Ganna, Andrea" uniqKey="Ganna A" first="Andrea" last="Ganna">Andrea Ganna</name><affiliation><nlm:aff id="A3">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Wheeler, Eleanor" sort="Wheeler, Eleanor" uniqKey="Wheeler E" first="Eleanor" last="Wheeler">Eleanor Wheeler</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Feitosa, Mary F" sort="Feitosa, Mary F" uniqKey="Feitosa M" first="Mary F." last="Feitosa">Mary F. Feitosa</name><affiliation><nlm:aff id="A7">Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Justice, Anne E" sort="Justice, Anne E" uniqKey="Justice A" first="Anne E." last="Justice">Anne E. Justice</name><affiliation><nlm:aff id="A8">Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, USA</nlm:aff></affiliation></author><author><name sortKey="Monda, Keri L" sort="Monda, Keri L" uniqKey="Monda K" first="Keri L." last="Monda">Keri L. Monda</name><affiliation><nlm:aff id="A8">Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Center for Observational Research, Amgen, Thousands Oaks, CA, 91320</nlm:aff></affiliation></author><author><name sortKey="Croteau Chonka, Damien C" sort="Croteau Chonka, Damien C" uniqKey="Croteau Chonka D" first="Damien C." last="Croteau-Chonka">Damien C. Croteau-Chonka</name><affiliation><nlm:aff id="A10">Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA</nlm:aff></affiliation></author><author><name sortKey="Day, Felix R" sort="Day, Felix R" uniqKey="Day F" first="Felix R." last="Day">Felix R. Day</name><affiliation><nlm:aff id="A11">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Fall, Tove" sort="Fall, Tove" uniqKey="Fall T" first="Tove" last="Fall">Tove Fall</name><affiliation><nlm:aff id="A3">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Ferreira, Teresa" sort="Ferreira, Teresa" uniqKey="Ferreira T" first="Teresa" last="Ferreira">Teresa Ferreira</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Gentilini, Davide" sort="Gentilini, Davide" uniqKey="Gentilini D" first="Davide" last="Gentilini">Davide Gentilini</name><affiliation><nlm:aff id="A13">Molecular Biology Department, Istituto Auxologico Italiano, Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Jackson, Anne U" sort="Jackson, Anne U" uniqKey="Jackson A" first="Anne U." last="Jackson">Anne U. Jackson</name><affiliation><nlm:aff id="A14">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Luan, Jian N" sort="Luan, Jian N" uniqKey="Luan J" first="Jian N" last="Luan">Jian N Luan</name><affiliation><nlm:aff id="A11">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Randall, Joshua C" sort="Randall, Joshua C" uniqKey="Randall J" first="Joshua C." last="Randall">Joshua C. Randall</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Vedantam, Sailaja" sort="Vedantam, Sailaja" uniqKey="Vedantam S" first="Sailaja" last="Vedantam">Sailaja Vedantam</name><affiliation><nlm:aff id="A15">Divisions of Genetics and Endocrinology and Center for Basic and Translational Obesity Research, Children’s Hospital, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Willer, Cristen J" sort="Willer, Cristen J" uniqKey="Willer C" first="Cristen J." last="Willer">Cristen J. Willer</name><affiliation><nlm:aff id="A18">Department of Internal Medicine (Cardiovascular), University of Michigan, Ann Arbor, MI 48109, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Department of Computational Medicine and Bioinformatics, University of Michigan, MI 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Winkler, Thomas W" sort="Winkler, Thomas W" uniqKey="Winkler T" first="Thomas W." last="Winkler">Thomas W. Winkler</name><affiliation><nlm:aff id="A21">Public Health and Gender Studies, Institute of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Wood, Andrew R" sort="Wood, Andrew R" uniqKey="Wood A" first="Andrew R." last="Wood">Andrew R. Wood</name><affiliation><nlm:aff id="A22">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, EX1 2LU, UK</nlm:aff></affiliation></author><author><name sortKey="Workalemahu, Tsegaselassie" sort="Workalemahu, Tsegaselassie" uniqKey="Workalemahu T" first="Tsegaselassie" last="Workalemahu">Tsegaselassie Workalemahu</name><affiliation><nlm:aff id="A23">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Hu, Yi Juan" sort="Hu, Yi Juan" uniqKey="Hu Y" first="Yi-Juan" last="Hu">Yi-Juan Hu</name><affiliation><nlm:aff id="A25">Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia 30322, USA</nlm:aff></affiliation></author><author><name sortKey="Lee, Sang Hong" sort="Lee, Sang Hong" uniqKey="Lee S" first="Sang Hong" last="Lee">Sang Hong Lee</name><affiliation><nlm:aff id="A26">The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Liang, Liming" sort="Liang, Liming" uniqKey="Liang L" first="Liming" last="Liang">Liming Liang</name><affiliation><nlm:aff id="A27">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Lin, Dan Yu" sort="Lin, Dan Yu" uniqKey="Lin D" first="Dan-Yu" last="Lin">Dan-Yu Lin</name><affiliation><nlm:aff id="A29">Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff></affiliation></author><author><name sortKey="Min, Josine L" sort="Min, Josine L" uniqKey="Min J" first="Josine L." last="Min">Josine L. Min</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Neale, Benjamin M" sort="Neale, Benjamin M" uniqKey="Neale B" first="Benjamin M." last="Neale">Benjamin M. Neale</name><affiliation><nlm:aff id="A30">Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114</nlm:aff></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation><nlm:aff id="A31">deCODE Genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Yang, Jian" sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name><affiliation><nlm:aff id="A32">University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Queensland Institute of Medical Research, Brisbane 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Albrecht, Eva" sort="Albrecht, Eva" uniqKey="Albrecht E" first="Eva" last="Albrecht">Eva Albrecht</name><affiliation><nlm:aff id="A34">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation><nlm:aff id="A35">Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Bragg Gresham, Jennifer L" sort="Bragg Gresham, Jennifer L" uniqKey="Bragg Gresham J" first="Jennifer L." last="Bragg-Gresham">Jennifer L. Bragg-Gresham</name><affiliation><nlm:aff id="A14">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Cadby, Gemma" sort="Cadby, Gemma" uniqKey="Cadby G" first="Gemma" last="Cadby">Gemma Cadby</name><affiliation><nlm:aff id="A36">Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research. Toronto, Canada, M5G 1L7</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Toronto, Canada, M5G 1X5</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="Den Heijer, Martin" sort="Den Heijer, Martin" uniqKey="Den Heijer M" first="Martin" last="Den Heijer">Martin Den Heijer</name><affiliation><nlm:aff id="A39">Department of Internal Medicine, VU University Medical Centre, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Eklund, Niina" sort="Eklund, Niina" uniqKey="Eklund N" first="Niina" last="Eklund">Niina Eklund</name><affiliation><nlm:aff id="A40">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</nlm:aff></affiliation></author><author><name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name><affiliation><nlm:aff id="A41">Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Oxford, OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation><nlm:aff id="A42">Department of Biological Psychology, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Huffman, Jennifer E" sort="Huffman, Jennifer E" uniqKey="Huffman J" first="Jennifer E." last="Huffman">Jennifer E. Huffman</name><affiliation><nlm:aff id="A43">MRC Human Genetics Unit, MRC Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, UK</nlm:aff></affiliation></author><author><name sortKey="Jarick, Ivonne" sort="Jarick, Ivonne" uniqKey="Jarick I" first="Ivonne" last="Jarick">Ivonne Jarick</name><affiliation><nlm:aff id="A44">Institute of Medical Biometry and Epidemiology, University of Marburg, 35037 Marburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation><nlm:aff id="A45">Department of Immunology, Genetics and Pathology, Uppsala University, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A46">Uppsala Clinical Research Center, Uppsala university hospital, Sweden</nlm:aff></affiliation></author><author><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name><affiliation><nlm:aff id="A47">Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kanoni, Stavroula" sort="Kanoni, Stavroula" uniqKey="Kanoni S" first="Stavroula" last="Kanoni">Stavroula Kanoni</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E." last="Kleber">Marcus E. Kleber</name><affiliation><nlm:aff id="A49">LURIC Study nonprofit LLC, Freiburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A50">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Konig, Inke R" sort="Konig, Inke R" uniqKey="Konig I" first="Inke R." last="König">Inke R. König</name><affiliation><nlm:aff id="A51">Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, 23562 Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Kristiansson, Kati" sort="Kristiansson, Kati" uniqKey="Kristiansson K" first="Kati" last="Kristiansson">Kati Kristiansson</name><affiliation><nlm:aff id="A40">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name><affiliation><nlm:aff id="A52">Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A53">Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Lamina, Claudia" sort="Lamina, Claudia" uniqKey="Lamina C" first="Claudia" last="Lamina">Claudia Lamina</name><affiliation><nlm:aff id="A54">Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria</nlm:aff></affiliation></author><author><name sortKey="Lecoeur, Cecile" sort="Lecoeur, Cecile" uniqKey="Lecoeur C" first="Cecile" last="Lecoeur">Cecile Lecoeur</name><affiliation><nlm:aff id="A55">University Lille Nord de France, 59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A56">CNRS UMR8199-IBL-Institut Pasteur de Lille, F-59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name><affiliation><nlm:aff id="A57">Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA</nlm:aff></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation><nlm:aff id="A58">Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L." last="Mcardle">Wendy L. Mcardle</name><affiliation><nlm:aff id="A59">School of Social and Community Medicine, University of Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Medina Gomez, Carolina" sort="Medina Gomez, Carolina" uniqKey="Medina Gomez C" first="Carolina" last="Medina-Gomez">Carolina Medina-Gomez</name><affiliation><nlm:aff id="A35">Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A60">Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name><affiliation><nlm:aff id="A34">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A63">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology and Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Ngwa, Julius S" sort="Ngwa, Julius S" uniqKey="Ngwa J" first="Julius S." last="Ngwa">Julius S. Ngwa</name><affiliation><nlm:aff id="A64">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M." last="Nolte">Ilja M. Nolte</name><affiliation><nlm:aff id="A65">Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Paternoster, Lavinia" sort="Paternoster, Lavinia" uniqKey="Paternoster L" first="Lavinia" last="Paternoster">Lavinia Paternoster</name><affiliation><nlm:aff id="A66">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Pechlivanis, Sonali" sort="Pechlivanis, Sonali" uniqKey="Pechlivanis S" first="Sonali" last="Pechlivanis">Sonali Pechlivanis</name><affiliation><nlm:aff id="A67">Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital of Essen, University of Duisburg-Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A40">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Peters, Marjolein J" sort="Peters, Marjolein J" uniqKey="Peters M" first="Marjolein J." last="Peters">Marjolein J. Peters</name><affiliation><nlm:aff id="A35">Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A60">Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Preuss, Michael" sort="Preuss, Michael" uniqKey="Preuss M" first="Michael" last="Preuss">Michael Preuss</name><affiliation><nlm:aff id="A51">Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, 23562 Lübeck, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A69">Universität zu Lübeck, Medizinische Klinik II, 23538 Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Rose, Lynda M" sort="Rose, Lynda M" uniqKey="Rose L" first="Lynda M." last="Rose">Lynda M. Rose</name><affiliation><nlm:aff id="A70">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts 02215, USA</nlm:aff></affiliation></author><author><name sortKey="Shi, Jianxin" sort="Shi, Jianxin" uniqKey="Shi J" first="Jianxin" last="Shi">Jianxin Shi</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Shungin, Dmitry" sort="Shungin, Dmitry" uniqKey="Shungin D" first="Dmitry" last="Shungin">Dmitry Shungin</name><affiliation><nlm:aff id="A71">Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Lund University, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Department of Public Health & Clinical Medicine, Umeå University, Umeå, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Department of Odontology, Umeå University, Sweden</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name><affiliation><nlm:aff id="A74">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A75">Department of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Strawbridge, Rona J" sort="Strawbridge, Rona J" uniqKey="Strawbridge R" first="Rona J." last="Strawbridge">Rona J. Strawbridge</name><affiliation><nlm:aff id="A76">Atherosclerosis Research Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Surakka, Ida" sort="Surakka, Ida" uniqKey="Surakka I" first="Ida" last="Surakka">Ida Surakka</name><affiliation><nlm:aff id="A40">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:aff id="A77">Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, 17487 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Trip, Mieke D" sort="Trip, Mieke D" uniqKey="Trip M" first="Mieke D." last="Trip">Mieke D. Trip</name><affiliation><nlm:aff id="A78">Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A79">Heart Failure Research Centre, Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Tyrer, Jonathan" sort="Tyrer, Jonathan" uniqKey="Tyrer J" first="Jonathan" last="Tyrer">Jonathan Tyrer</name><affiliation><nlm:aff id="A80">Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Van Vliet Ostaptchouk, Jana V" sort="Van Vliet Ostaptchouk, Jana V" uniqKey="Van Vliet Ostaptchouk J" first="Jana V." last="Van Vliet-Ostaptchouk">Jana V. Van Vliet-Ostaptchouk</name><affiliation><nlm:aff id="A81">Department of Endocrinology, University Medical Center Groningen, University of Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A82">LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Vandenput, Liesbeth" sort="Vandenput, Liesbeth" uniqKey="Vandenput L" first="Liesbeth" last="Vandenput">Liesbeth Vandenput</name><affiliation><nlm:aff id="A83">Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Waite, Lindsay L" sort="Waite, Lindsay L" uniqKey="Waite L" first="Lindsay L." last="Waite">Lindsay L. Waite</name><affiliation><nlm:aff id="A84">Hudson Alpha Institute for Biotechnology, Huntsville, Alabama 35806, USA</nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="A11">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Absher, Devin" sort="Absher, Devin" uniqKey="Absher D" first="Devin" last="Absher">Devin Absher</name><affiliation><nlm:aff id="A84">Hudson Alpha Institute for Biotechnology, Huntsville, Alabama 35806, USA</nlm:aff></affiliation></author><author><name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W." last="Asselbergs">Folkert W. Asselbergs</name><affiliation><nlm:aff id="A85">Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Atalay, Mustafa" sort="Atalay, Mustafa" uniqKey="Atalay M" first="Mustafa" last="Atalay">Mustafa Atalay</name><affiliation><nlm:aff id="A86">Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Finland</nlm:aff></affiliation></author><author><name sortKey="Attwood, Antony P" sort="Attwood, Antony P" uniqKey="Attwood A" first="Antony P." last="Attwood">Antony P. Attwood</name><affiliation><nlm:aff id="A87">NIHR Cambridge Biomedical Research Centre, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Balmforth, Anthony J" sort="Balmforth, Anthony J" uniqKey="Balmforth A" first="Anthony J." last="Balmforth">Anthony J. Balmforth</name><affiliation><nlm:aff id="A88">Division of Epidemiology, Multidisciplinary Cardiovascular Research Centre (MCRC), Leeds Institute of Genetics, Health and Therapeutics (LIGHT), University of Leeds, Leeds LS2 9JT, UK</nlm:aff></affiliation></author><author><name sortKey="Basart, Hanneke" sort="Basart, Hanneke" uniqKey="Basart H" first="Hanneke" last="Basart">Hanneke Basart</name><affiliation><nlm:aff id="A78">Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Beilby, John" sort="Beilby, John" uniqKey="Beilby J" first="John" last="Beilby">John Beilby</name><affiliation><nlm:aff id="A89">PathWest Laboratory of Western Australia, Department of Molecular Genetics, J Block, QEII Medical Centre, Nedlands, Western Australia 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A90">Department of Surgery and Pathology, University of Western Australia, Nedlands, Australia, 6009</nlm:aff></affiliation></author><author><name sortKey="Bonnycastle, Lori L" sort="Bonnycastle, Lori L" uniqKey="Bonnycastle L" first="Lori L." last="Bonnycastle">Lori L. Bonnycastle</name><affiliation><nlm:aff id="A91">Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Brambilla, Paolo" sort="Brambilla, Paolo" uniqKey="Brambilla P" first="Paolo" last="Brambilla">Paolo Brambilla</name><affiliation><nlm:aff id="A92">Dipartimento di Medicina Sperimentale. Università degli Studi Milano-Bicocca, Monza, Italy</nlm:aff></affiliation></author><author><name sortKey="Bruinenberg, Marcel" sort="Bruinenberg, Marcel" uniqKey="Bruinenberg M" first="Marcel" last="Bruinenberg">Marcel Bruinenberg</name><affiliation><nlm:aff id="A82">LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="A93">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</nlm:aff></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name><affiliation><nlm:aff id="A70">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts 02215, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A94">Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Chines, Peter S" sort="Chines, Peter S" uniqKey="Chines P" first="Peter S." last="Chines">Peter S. Chines</name><affiliation><nlm:aff id="A91">Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Collins, Francis S" sort="Collins, Francis S" uniqKey="Collins F" first="Francis S." last="Collins">Francis S. Collins</name><affiliation><nlm:aff id="A91">Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Connell, John M" sort="Connell, John M" uniqKey="Connell J" first="John M." last="Connell">John M. Connell</name><affiliation><nlm:aff id="A95">British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, G12 8TA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A96">University of Dundee, Ninewells Hospital &Medical School, Dundee, DD1 9SY, UK</nlm:aff></affiliation></author><author><name sortKey="Cookson, William" sort="Cookson, William" uniqKey="Cookson W" first="William" last="Cookson">William Cookson</name><affiliation><nlm:aff id="A97">National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK</nlm:aff></affiliation></author><author><name sortKey="De Faire, Ulf" sort="De Faire, Ulf" uniqKey="De Faire U" first="Ulf" last="De Faire">Ulf De Faire</name><affiliation><nlm:aff id="A98">Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="De Vegt, Femmie" sort="De Vegt, Femmie" uniqKey="De Vegt F" first="Femmie" last="De Vegt">Femmie De Vegt</name><affiliation><nlm:aff id="A99">Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Dei, Mariano" sort="Dei, Mariano" uniqKey="Dei M" first="Mariano" last="Dei">Mariano Dei</name><affiliation><nlm:aff id="A100">Istituto di Ricerca Genetica e Biomedicadel del CNR, Monserrato, 09042, Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Dimitriou, Maria" sort="Dimitriou, Maria" uniqKey="Dimitriou M" first="Maria" last="Dimitriou">Maria Dimitriou</name><affiliation><nlm:aff id="A101">Department of Dietetics-Nutrition, Harokopio University, 70 El. Venizelou Str, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Edkins, Sarah" sort="Edkins, Sarah" uniqKey="Edkins S" first="Sarah" last="Edkins">Sarah Edkins</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Estrada, Karol" sort="Estrada, Karol" uniqKey="Estrada K" first="Karol" last="Estrada">Karol Estrada</name><affiliation><nlm:aff id="A35">Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A60">Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name><affiliation><nlm:aff id="A66">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Farrall, Martin" sort="Farrall, Martin" uniqKey="Farrall M" first="Martin" last="Farrall">Martin Farrall</name><affiliation><nlm:aff id="A41">Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Oxford, OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Ferrario, Marco M" sort="Ferrario, Marco M" uniqKey="Ferrario M" first="Marco M." last="Ferrario">Marco M. Ferrario</name><affiliation><nlm:aff id="A102">Epidemiology and Preventive Medicine Research Center, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy</nlm:aff></affiliation></author><author><name sortKey="Ferrieres, Jean" sort="Ferrieres, Jean" uniqKey="Ferrieres J" first="Jean" last="Ferrières">Jean Ferrières</name><affiliation><nlm:aff id="A103">Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, France</nlm:aff></affiliation></author><author><name sortKey="Franke, Lude" sort="Franke, Lude" uniqKey="Franke L" first="Lude" last="Franke">Lude Franke</name><affiliation><nlm:aff id="A82">LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A104">Department of Genetics, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Frau, Francesca" sort="Frau, Francesca" uniqKey="Frau F" first="Francesca" last="Frau">Francesca Frau</name><affiliation><nlm:aff id="A105">University of Milan, Department of Health Sciences, Ospedale San Paolo, 20139 Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Gejman, Pablo V" sort="Gejman, Pablo V" uniqKey="Gejman P" first="Pablo V." last="Gejman">Pablo V. Gejman</name><affiliation><nlm:aff id="A106">University of Chicago, Chicago, Illinois 60637, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A107">Northshore University HealthSystem, Evanston, Illinois 60201, USA</nlm:aff></affiliation></author><author><name sortKey="Grallert, Harald" sort="Grallert, Harald" uniqKey="Grallert H" first="Harald" last="Grallert">Harald Grallert</name><affiliation><nlm:aff id="A108">Research Unit for Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name><affiliation><nlm:aff id="A3">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="A74">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A75">Department of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Hall, Alistair S" sort="Hall, Alistair S" uniqKey="Hall A" first="Alistair S." last="Hall">Alistair S. Hall</name><affiliation><nlm:aff id="A109">Division of Cardiovascular and Neuronal Remodelling, Multidisciplinary Cardiovascular Research Centre, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, UK</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="A3">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation><nlm:aff id="A110">Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="A43">MRC Human Genetics Unit, MRC Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, UK</nlm:aff></affiliation></author><author><name sortKey="Heard Costa, Nancy L" sort="Heard Costa, Nancy L" uniqKey="Heard Costa N" first="Nancy L." last="Heard-Costa">Nancy L. Heard-Costa</name><affiliation><nlm:aff id="A111">Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Heath, Andrew C" sort="Heath, Andrew C" uniqKey="Heath A" first="Andrew C." last="Heath">Andrew C. Heath</name><affiliation><nlm:aff id="A112">Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63108, USA</nlm:aff></affiliation></author><author><name sortKey="Hebebrand, Johannes" sort="Hebebrand, Johannes" uniqKey="Hebebrand J" first="Johannes" last="Hebebrand">Johannes Hebebrand</name><affiliation><nlm:aff id="A113">Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, 45147 Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name><affiliation><nlm:aff id="A77">Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, 17487 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B." last="Hu">Frank B. Hu</name><affiliation><nlm:aff id="A23">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Hunt, Sarah E" sort="Hunt, Sarah E" uniqKey="Hunt S" first="Sarah E." last="Hunt">Sarah E. Hunt</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><affiliation><nlm:aff id="A114">Centre For Paediatric Epidemiolgy and Biostatistics/MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Iribarren, Carlos" sort="Iribarren, Carlos" uniqKey="Iribarren C" first="Carlos" last="Iribarren">Carlos Iribarren</name><affiliation><nlm:aff id="A115">Division of Research, Kaiser Permanente Northern California, Oakland, California 94612, USA</nlm:aff></affiliation></author><author><name sortKey="Jacobs, Kevin B" sort="Jacobs, Kevin B" uniqKey="Jacobs K" first="Kevin B." last="Jacobs">Kevin B. Jacobs</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A116">Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA</nlm:aff></affiliation></author><author><name sortKey="Jansson, John Olov" sort="Jansson, John Olov" uniqKey="Jansson J" first="John-Olov" last="Jansson">John-Olov Jansson</name><affiliation><nlm:aff id="A117">Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Jula, Antti" sort="Jula, Antti" uniqKey="Jula A" first="Antti" last="Jula">Antti Jula</name><affiliation><nlm:aff id="A118">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Population Studies Unit, 20720 Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:aff id="A119">Department of Clinical Physiology, University of Tampere and Tampere University Hospital, 33520 Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Kathiresan, Sekar" sort="Kathiresan, Sekar" uniqKey="Kathiresan S" first="Sekar" last="Kathiresan">Sekar Kathiresan</name><affiliation><nlm:aff id="A120">Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A121">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A122">Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation></author><author><name sortKey="Kee, Frank" sort="Kee, Frank" uniqKey="Kee F" first="Frank" last="Kee">Frank Kee</name><affiliation><nlm:aff id="A123">UKCRC Centre of Excellence for Public Health (NI) Queens University, Belfast</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:aff id="A124">Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge CB2 2SR, UK</nlm:aff></affiliation></author><author><name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name><affiliation><nlm:aff id="A125">Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, UK</nlm:aff></affiliation></author><author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name><affiliation><nlm:aff id="A126">Department of Internal Medicine II – Cardiology, University of Ulm Medical Center, Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Kraja, Aldi T" sort="Kraja, Aldi T" uniqKey="Kraja A" first="Aldi T." last="Kraja">Aldi T. Kraja</name><affiliation><nlm:aff id="A7">Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name><affiliation><nlm:aff id="A125">Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, UK</nlm:aff></affiliation></author><author><name sortKey="Kuulasmaa, Kari" sort="Kuulasmaa, Kari" uniqKey="Kuulasmaa K" first="Kari" last="Kuulasmaa">Kari Kuulasmaa</name><affiliation><nlm:aff id="A127">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, 00271, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kuusisto, Johanna" sort="Kuusisto, Johanna" uniqKey="Kuusisto J" first="Johanna" last="Kuusisto">Johanna Kuusisto</name><affiliation><nlm:aff id="A128">Department of Medicine, University of Eastern Finland, Kuopio Campus and Kuopio University Hospital, 70210 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Laitinen, Jaana H" sort="Laitinen, Jaana H" uniqKey="Laitinen J" first="Jaana H." last="Laitinen">Jaana H. Laitinen</name><affiliation><nlm:aff id="A129">Finnish Institute of Occupational Health, 90220 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Lakka, Timo A" sort="Lakka, Timo A" uniqKey="Lakka T" first="Timo A." last="Lakka">Timo A. Lakka</name><affiliation><nlm:aff id="A86">Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A130">Kuopio Research Institute of Exercise Medicine, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation><nlm:aff id="A11">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A125">Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, UK</nlm:aff></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><affiliation><nlm:aff id="A131">Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation><nlm:aff id="A132">Department of Medical Sciences, Uppsala University, Akademiska sjukhuset, 751 85 Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Jaana" sort="Lindstrom, Jaana" uniqKey="Lindstrom J" first="Jaana" last="Lindström">Jaana Lindström</name><affiliation><nlm:aff id="A133">National Institute for Health and Welfare, Diabetes Prevention Unit, 00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:aff id="A134">Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore</nlm:aff></affiliation></author><author><name sortKey="Liuzzi, Antonio" sort="Liuzzi, Antonio" uniqKey="Liuzzi A" first="Antonio" last="Liuzzi">Antonio Liuzzi</name><affiliation><nlm:aff id="A135">Department of Internal Medicine, Istituto Auxologico Italiano, Verbania, Italy</nlm:aff></affiliation></author><author><name sortKey="Lokki, Marja Liisa" sort="Lokki, Marja Liisa" uniqKey="Lokki M" first="Marja-Liisa" last="Lokki">Marja-Liisa Lokki</name><affiliation><nlm:aff id="A136">Transplantation Laboratory, Haartman Institute, University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Lorentzon, Mattias" sort="Lorentzon, Mattias" uniqKey="Lorentzon M" first="Mattias" last="Lorentzon">Mattias Lorentzon</name><affiliation><nlm:aff id="A83">Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Madden, Pamela A" sort="Madden, Pamela A" uniqKey="Madden P" first="Pamela A." last="Madden">Pamela A. Madden</name><affiliation><nlm:aff id="A112">Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63108, USA</nlm:aff></affiliation></author><author><name sortKey="Magnusson, Patrik K" sort="Magnusson, Patrik K" uniqKey="Magnusson P" first="Patrik K." last="Magnusson">Patrik K. Magnusson</name><affiliation><nlm:aff id="A3">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Manunta, Paolo" sort="Manunta, Paolo" uniqKey="Manunta P" first="Paolo" last="Manunta">Paolo Manunta</name><affiliation><nlm:aff id="A137">Università Vita-Salute San Raffaele, Chair of Nephrology San Raffaele Scientific Institute, OU Nephrology and Dialysis, 20132 Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Marek, Diana" sort="Marek, Diana" uniqKey="Marek D" first="Diana" last="Marek">Diana Marek</name><affiliation><nlm:aff id="A52">Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A53">Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="M Rz, Winfried" sort="M Rz, Winfried" uniqKey="M Rz W" first="Winfried" last="M Rz">Winfried M Rz</name><affiliation><nlm:aff id="A50">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A138">Synlab Academy, Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Mateo Leach, Irene" sort="Mateo Leach, Irene" uniqKey="Mateo Leach I" first="Irene" last="Mateo Leach">Irene Mateo Leach</name><affiliation><nlm:aff id="A139">Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name><affiliation><nlm:aff id="A140">Departments of Biostatistics, University of Washington, Seattle, Washington 98195, USA</nlm:aff></affiliation></author><author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name><affiliation><nlm:aff id="A33">Queensland Institute of Medical Research, Brisbane 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Mihailov, Evelin" sort="Mihailov, Evelin" uniqKey="Mihailov E" first="Evelin" last="Mihailov">Evelin Mihailov</name><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Milani, Lili" sort="Milani, Lili" uniqKey="Milani L" first="Lili" last="Milani">Lili Milani</name><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</nlm:aff></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation><nlm:aff id="A33">Queensland Institute of Medical Research, Brisbane 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Mooser, Vincent" sort="Mooser, Vincent" uniqKey="Mooser V" first="Vincent" last="Mooser">Vincent Mooser</name><affiliation><nlm:aff id="A141">Genetics Division, GlaxoSmithKline, King of Prussia, Pennsylvania 19406, USA</nlm:aff></affiliation></author><author><name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W." last="Mühleisen">Thomas W. Mühleisen</name><affiliation><nlm:aff id="A142">Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A143">Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Munroe, Patricia B" sort="Munroe, Patricia B" uniqKey="Munroe P" first="Patricia B." last="Munroe">Patricia B. Munroe</name><affiliation><nlm:aff id="A47">Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Musk, Arthur W" sort="Musk, Arthur W" uniqKey="Musk A" first="Arthur W." last="Musk">Arthur W. Musk</name><affiliation><nlm:aff id="A144">School of Population Health, The University of Western Australia, Nedlands WA 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A145">Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Australia, 6009</nlm:aff></affiliation><affiliation><nlm:aff id="A146">Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="Narisu, Narisu" sort="Narisu, Narisu" uniqKey="Narisu N" first="Narisu" last="Narisu">Narisu Narisu</name><affiliation><nlm:aff id="A91">Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name><affiliation><nlm:aff id="A147">Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen</nlm:aff></affiliation></author><author><name sortKey="Nicholson, George" sort="Nicholson, George" uniqKey="Nicholson G" first="George" last="Nicholson">George Nicholson</name><affiliation><nlm:aff id="A148">MRC Harwell, Harwell, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A149">Department of Statistics, University of Oxford, Oxford OX1 3TG, UK</nlm:aff></affiliation></author><author><name sortKey="Nohr, Ellen A" sort="Nohr, Ellen A" uniqKey="Nohr E" first="Ellen A." last="Nohr">Ellen A. Nohr</name><affiliation><nlm:aff id="A150">Department of Public Health, Section of Epidemiology, Aarhus University, Denmark</nlm:aff></affiliation></author><author><name sortKey="Ong, Ken K" sort="Ong, Ken K" uniqKey="Ong K" first="Ken K." last="Ong">Ken K. Ong</name><affiliation><nlm:aff id="A11">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A151">MRC Unit for Lifelong Health & Ageing, London, UK</nlm:aff></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name><affiliation><nlm:aff id="A61">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation><affiliation><nlm:aff id="A152">Department of Clinical Genetics, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A153">Centre for Medical Systems Biology & Netherlands Consortium on Healthy Aging, Leiden, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Palmer, Colin N A" sort="Palmer, Colin N A" uniqKey="Palmer C" first="Colin N. A." last="Palmer">Colin N. A. Palmer</name><affiliation><nlm:aff id="A154">Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School. Dundee, DD1 9SY</nlm:aff></affiliation></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Peden, John F" sort="Peden, John F" uniqKey="Peden J" first="John F." last="Peden">John F. Peden</name><affiliation><nlm:aff id="A155">Illumina Inc. Cambridge</nlm:aff></affiliation></author><author><name sortKey="Pedersen, Nancy" sort="Pedersen, Nancy" uniqKey="Pedersen N" first="Nancy" last="Pedersen">Nancy Pedersen</name><affiliation><nlm:aff id="A3">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name><affiliation><nlm:aff id="A108">Research Unit for Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A156">Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A157">Munich Heart Alliance, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation><nlm:aff id="A158">Faculty of Medicine, University of Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation><nlm:aff id="A110">Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A159">National Institute for Health and Welfare, 90101 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><affiliation><nlm:aff id="A160">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, 39100, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A161">Department of Neurology, General Central Hospital, Bolzano, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A162">Department of Neurology, University of Lübeck, Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A163">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Putter, Carolin" sort="Putter, Carolin" uniqKey="Putter C" first="Carolin" last="Pütter">Carolin Pütter</name><affiliation><nlm:aff id="A67">Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital of Essen, University of Duisburg-Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Radhakrishnan, Aparna" sort="Radhakrishnan, Aparna" uniqKey="Radhakrishnan A" first="Aparna" last="Radhakrishnan">Aparna Radhakrishnan</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A164">Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A165">NHS Blood and Transplant, Cambridge Centre, Cambridge, CB2 0PT, UK</nlm:aff></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation><nlm:aff id="A166">Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520 Turku, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A167">The Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, 20520 Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Rendon, Augusto" sort="Rendon, Augusto" uniqKey="Rendon A" first="Augusto" last="Rendon">Augusto Rendon</name><affiliation><nlm:aff id="A87">NIHR Cambridge Biomedical Research Centre, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A164">Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A165">NHS Blood and Transplant, Cambridge Centre, Cambridge, CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A168">MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="A35">Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A60">Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="A93">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</nlm:aff></affiliation></author><author><name sortKey="Saaristo, Timo E" sort="Saaristo, Timo E" uniqKey="Saaristo T" first="Timo E." last="Saaristo">Timo E. Saaristo</name><affiliation><nlm:aff id="A169">Finnish Diabetes Association, Kirjoniementie 15, 33680, Tampere, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A170">Pirkanmaa Hospital District, Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Sambrook, Jennifer G" sort="Sambrook, Jennifer G" uniqKey="Sambrook J" first="Jennifer G." last="Sambrook">Jennifer G. Sambrook</name><affiliation><nlm:aff id="A164">Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A165">NHS Blood and Transplant, Cambridge Centre, Cambridge, CB2 0PT, UK</nlm:aff></affiliation></author><author><name sortKey="Sanders, Alan R" sort="Sanders, Alan R" uniqKey="Sanders A" first="Alan R." last="Sanders">Alan R. Sanders</name><affiliation><nlm:aff id="A106">University of Chicago, Chicago, Illinois 60637, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A107">Northshore University HealthSystem, Evanston, Illinois 60201, USA</nlm:aff></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation><nlm:aff id="A100">Istituto di Ricerca Genetica e Biomedicadel del CNR, Monserrato, 09042, Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Saramies, Jouko" sort="Saramies, Jouko" uniqKey="Saramies J" first="Jouko" last="Saramies">Jouko Saramies</name><affiliation><nlm:aff id="A171">South Karelia Central Hospital, 53130 Lappeenranta, Finland</nlm:aff></affiliation></author><author><name sortKey="Schipf, Sabine" sort="Schipf, Sabine" uniqKey="Schipf S" first="Sabine" last="Schipf">Sabine Schipf</name><affiliation><nlm:aff id="A172">Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Schreiber, Stefan" sort="Schreiber, Stefan" uniqKey="Schreiber S" first="Stefan" last="Schreiber">Stefan Schreiber</name><affiliation><nlm:aff id="A173">Institute for Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Schunkert, Heribert" sort="Schunkert, Heribert" uniqKey="Schunkert H" first="Heribert" last="Schunkert">Heribert Schunkert</name><affiliation><nlm:aff id="A69">Universität zu Lübeck, Medizinische Klinik II, 23538 Lübeck, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A174">Deutsches Zentrum für Herz-Kreislaufforschung e. V. (DZHK), Universität zu Lübeck, 23538 Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Shin, So Youn" sort="Shin, So Youn" uniqKey="Shin S" first="So-Youn" last="Shin">So-Youn Shin</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Signorini, Stefano" sort="Signorini, Stefano" uniqKey="Signorini S" first="Stefano" last="Signorini">Stefano Signorini</name><affiliation><nlm:aff id="A175">Azienda ospedaliera di Desio e Vimercate, Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Sinisalo, Juha" sort="Sinisalo, Juha" uniqKey="Sinisalo J" first="Juha" last="Sinisalo">Juha Sinisalo</name><affiliation><nlm:aff id="A176">Division of Cardiology, Cardiovascular Laboratory, Helsinki University Central Hospital, 00029 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Skrobek, Boris" sort="Skrobek, Boris" uniqKey="Skrobek B" first="Boris" last="Skrobek">Boris Skrobek</name><affiliation><nlm:aff id="A55">University Lille Nord de France, 59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A56">CNRS UMR8199-IBL-Institut Pasteur de Lille, F-59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A58">Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Stan Kova, Alena" sort="Stan Kova, Alena" uniqKey="Stan Kova A" first="Alena" last="Stan Ková">Alena Stan Ková</name><affiliation><nlm:aff id="A177">University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Stark, Klaus" sort="Stark, Klaus" uniqKey="Stark K" first="Klaus" last="Stark">Klaus Stark</name><affiliation><nlm:aff id="A178">Klinik und Poliklinik für Innere Medizin II, Universitätklinikum Regensburg, 93053 Regensburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Stephens, Jonathan C" sort="Stephens, Jonathan C" uniqKey="Stephens J" first="Jonathan C." last="Stephens">Jonathan C. Stephens</name><affiliation><nlm:aff id="A164">Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A165">NHS Blood and Transplant, Cambridge Centre, Cambridge, CB2 0PT, UK</nlm:aff></affiliation></author><author><name sortKey="Stirrups, Kathleen" sort="Stirrups, Kathleen" uniqKey="Stirrups K" first="Kathleen" last="Stirrups">Kathleen Stirrups</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Stolk, Ronald P" sort="Stolk, Ronald P" uniqKey="Stolk R" first="Ronald P." last="Stolk">Ronald P. Stolk</name><affiliation><nlm:aff id="A65">Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A82">LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation><nlm:aff id="A179">Department of Medicine, University of Leipzig, 04103 Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A180">University of Leipzig, IFB Adiposity Diseases, Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Swift, Amy J" sort="Swift, Amy J" uniqKey="Swift A" first="Amy J." last="Swift">Amy J. Swift</name><affiliation><nlm:aff id="A91">Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Theodoraki, Eirini V" sort="Theodoraki, Eirini V" uniqKey="Theodoraki E" first="Eirini V." last="Theodoraki">Eirini V. Theodoraki</name><affiliation><nlm:aff id="A101">Department of Dietetics-Nutrition, Harokopio University, 70 El. Venizelou Str, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Thorand, Barbara" sort="Thorand, Barbara" uniqKey="Thorand B" first="Barbara" last="Thorand">Barbara Thorand</name><affiliation><nlm:aff id="A156">Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Tregouet, David Alexandre" sort="Tregouet, David Alexandre" uniqKey="Tregouet D" first="David-Alexandre" last="Tregouet">David-Alexandre Tregouet</name><affiliation><nlm:aff id="A181">INSERM UMR_S 937, ICAN Institute, Pierre et Marie Curie Medical School, Paris 75013, France</nlm:aff></affiliation></author><author><name sortKey="Tremoli, Elena" sort="Tremoli, Elena" uniqKey="Tremoli E" first="Elena" last="Tremoli">Elena Tremoli</name><affiliation><nlm:aff id="A182">Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Centro Cardiologico Monzino, IRCCS, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Van Der Klauw, Melanie M" sort="Van Der Klauw, Melanie M" uniqKey="Van Der Klauw M" first="Melanie M." last="Van Der Klauw">Melanie M. Van Der Klauw</name><affiliation><nlm:aff id="A81">Department of Endocrinology, University Medical Center Groningen, University of Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A82">LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Meurs, Joyce B J" sort="Van Meurs, Joyce B J" uniqKey="Van Meurs J" first="Joyce B. J." last="Van Meurs">Joyce B. J. Van Meurs</name><affiliation><nlm:aff id="A35">Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A60">Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Vermeulen, Sita H" sort="Vermeulen, Sita H" uniqKey="Vermeulen S" first="Sita H." last="Vermeulen">Sita H. Vermeulen</name><affiliation><nlm:aff id="A99">Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A183">Department of Human Genetics, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Viikari, Jorma" sort="Viikari, Jorma" uniqKey="Viikari J" first="Jorma" last="Viikari">Jorma Viikari</name><affiliation><nlm:aff id="A184">Department of Medicine, University of Turku and Turku University Hospital, 20520 Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation><nlm:aff id="A127">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, 00271, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation><nlm:aff id="A43">MRC Human Genetics Unit, MRC Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, UK</nlm:aff></affiliation></author><author><name sortKey="Waeber, Gerard" sort="Waeber, Gerard" uniqKey="Waeber G" first="Gérard" last="Waeber">Gérard Waeber</name><affiliation><nlm:aff id="A185">Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, 1011 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A116">Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA</nlm:aff></affiliation></author><author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widén">Elisabeth Widén</name><affiliation><nlm:aff id="A68">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name><affiliation><nlm:aff id="A93">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</nlm:aff></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation><nlm:aff id="A42">Department of Biological Psychology, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Winkelmann, Bernhard R" sort="Winkelmann, Bernhard R" uniqKey="Winkelmann B" first="Bernhard R." last="Winkelmann">Bernhard R. Winkelmann</name><affiliation><nlm:aff id="A186">Cardiology Group, Frankfurt-Sachsenhausen, Germany</nlm:aff></affiliation></author><author><name sortKey="Witteman, Jacqueline C M" sort="Witteman, Jacqueline C M" uniqKey="Witteman J" first="Jacqueline C. M." last="Witteman">Jacqueline C. M. Witteman</name><affiliation><nlm:aff id="A35">Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Wolffenbuttel, Bruce H R" sort="Wolffenbuttel, Bruce H R" uniqKey="Wolffenbuttel B" first="Bruce H. R." last="Wolffenbuttel">Bruce H. R. Wolffenbuttel</name><affiliation><nlm:aff id="A81">Department of Endocrinology, University Medical Center Groningen, University of Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A82">LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wong, Andrew" sort="Wong, Andrew" uniqKey="Wong A" first="Andrew" last="Wong">Andrew Wong</name><affiliation><nlm:aff id="A151">MRC Unit for Lifelong Health & Ageing, London, UK</nlm:aff></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name><affiliation><nlm:aff id="A43">MRC Human Genetics Unit, MRC Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, UK</nlm:aff></affiliation></author><author><name sortKey="Zillikens, M Carola" sort="Zillikens, M Carola" uniqKey="Zillikens M" first="M. Carola" last="Zillikens">M. Carola Zillikens</name><affiliation><nlm:aff id="A60">Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation><nlm:aff id="A187">Institut Pasteur de Lille, INSERM U744, Université Lille Nord de France, F-59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Boehm, Bernhard O" sort="Boehm, Bernhard O" uniqKey="Boehm B" first="Bernhard O." last="Boehm">Bernhard O. Boehm</name><affiliation><nlm:aff id="A188">Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation><nlm:aff id="A189">Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:aff id="A42">Department of Biological Psychology, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Caulfield, Mark J" sort="Caulfield, Mark J" uniqKey="Caulfield M" first="Mark J." last="Caulfield">Mark J. Caulfield</name><affiliation><nlm:aff id="A47">Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Cupples, L Adrienne" sort="Cupples, L Adrienne" uniqKey="Cupples L" first="L. Adrienne" last="Cupples">L. Adrienne Cupples</name><affiliation><nlm:aff id="A64">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Cusi, Daniele" sort="Cusi, Daniele" uniqKey="Cusi D" first="Daniele" last="Cusi">Daniele Cusi</name><affiliation><nlm:aff id="A105">University of Milan, Department of Health Sciences, Ospedale San Paolo, 20139 Milano, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A190">Fondazione Filarete, Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Dedoussis, George V" sort="Dedoussis, George V" uniqKey="Dedoussis G" first="George V." last="Dedoussis">George V. Dedoussis</name><affiliation><nlm:aff id="A101">Department of Dietetics-Nutrition, Harokopio University, 70 El. Venizelou Str, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Erdmann, Jeanette" sort="Erdmann, Jeanette" uniqKey="Erdmann J" first="Jeanette" last="Erdmann">Jeanette Erdmann</name><affiliation><nlm:aff id="A69">Universität zu Lübeck, Medizinische Klinik II, 23538 Lübeck, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A174">Deutsches Zentrum für Herz-Kreislaufforschung e. V. (DZHK), Universität zu Lübeck, 23538 Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G." last="Eriksson">Johan G. Eriksson</name><affiliation><nlm:aff id="A191">Department of General Practice and Primary health Care, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A192">National Institute for Health and Welfare, 00271 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A193">Helsinki University Central Hospital, Unit of General Practice, 00280 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Franks, Paul W" sort="Franks, Paul W" uniqKey="Franks P" first="Paul W." last="Franks">Paul W. Franks</name><affiliation><nlm:aff id="A71">Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Lund University, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Department of Public Health & Clinical Medicine, Umeå University, Umeå, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A194">Department of Nutrition, Harvard School of Public Health, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="A55">University Lille Nord de France, 59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A56">CNRS UMR8199-IBL-Institut Pasteur de Lille, F-59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A195">Department of Genomics of Common Disease, School of Public Health, Imperial College London, W12 0NN, London, UK</nlm:aff></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation><nlm:aff id="A34">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation><nlm:aff id="A45">Department of Immunology, Genetics and Pathology, Uppsala University, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name><affiliation><nlm:aff id="A76">Atherosclerosis Research Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="A131">Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Hengstenberg, Christian" sort="Hengstenberg, Christian" uniqKey="Hengstenberg C" first="Christian" last="Hengstenberg">Christian Hengstenberg</name><affiliation><nlm:aff id="A178">Klinik und Poliklinik für Innere Medizin II, Universitätklinikum Regensburg, 93053 Regensburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A." last="Hicks">Andrew A. Hicks</name><affiliation><nlm:aff id="A160">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, 39100, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Hingorani, Aroon" sort="Hingorani, Aroon" uniqKey="Hingorani A" first="Aroon" last="Hingorani">Aroon Hingorani</name><affiliation><nlm:aff id="A125">Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, UK</nlm:aff></affiliation></author><author><name sortKey="Hinney, Anke" sort="Hinney, Anke" uniqKey="Hinney A" first="Anke" last="Hinney">Anke Hinney</name><affiliation><nlm:aff id="A113">Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, 45147 Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A35">Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Hovingh, Kees G" sort="Hovingh, Kees G" uniqKey="Hovingh K" first="Kees G." last="Hovingh">Kees G. Hovingh</name><affiliation><nlm:aff id="A78">Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hveem, Kristian" sort="Hveem, Kristian" uniqKey="Hveem K" first="Kristian" last="Hveem">Kristian Hveem</name><affiliation><nlm:aff id="A196">HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway</nlm:aff></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation><nlm:aff id="A108">Research Unit for Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A197">Hannover Unified Biobank, Hannover Medical School, 30625 Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation><nlm:aff id="A159">National Institute for Health and Welfare, 90101 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A198">Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, W2 1PG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A199">Institute of Health Sciences, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A200">Biocenter Oulu, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Jockel, Karl Heinz" sort="Jockel, Karl Heinz" uniqKey="Jockel K" first="Karl-Heinz" last="Jöckel">Karl-Heinz Jöckel</name><affiliation><nlm:aff id="A67">Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital of Essen, University of Duisburg-Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Keinanen Kiukaanniemi, Sirkka M" sort="Keinanen Kiukaanniemi, Sirkka M" uniqKey="Keinanen Kiukaanniemi S" first="Sirkka M." last="Keinanen-Kiukaanniemi">Sirkka M. Keinanen-Kiukaanniemi</name><affiliation><nlm:aff id="A199">Institute of Health Sciences, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A201">Unit of General Practice, Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Kiemeney, Lambertus A" sort="Kiemeney, Lambertus A" uniqKey="Kiemeney L" first="Lambertus A." last="Kiemeney">Lambertus A. Kiemeney</name><affiliation><nlm:aff id="A99">Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A202">Department of Urology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A203">Comprehensive Cancer Center East, 6501 BG Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kuh, Diana" sort="Kuh, Diana" uniqKey="Kuh D" first="Diana" last="Kuh">Diana Kuh</name><affiliation><nlm:aff id="A151">MRC Unit for Lifelong Health & Ageing, London, UK</nlm:aff></affiliation></author><author><name sortKey="Laakso, Markku" sort="Laakso, Markku" uniqKey="Laakso M" first="Markku" last="Laakso">Markku Laakso</name><affiliation><nlm:aff id="A128">Department of Medicine, University of Eastern Finland, Kuopio Campus and Kuopio University Hospital, 70210 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:aff id="A204">Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere and Tampere University Hospital, 33520 Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Levinson, Douglas F" sort="Levinson, Douglas F" uniqKey="Levinson D" first="Douglas F." last="Levinson">Douglas F. Levinson</name><affiliation><nlm:aff id="A205">Stanford University School of Medicine, Stanford, California 93405, USA</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="A33">Queensland Institute of Medical Research, Brisbane 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Morris, Andrew D" sort="Morris, Andrew D" uniqKey="Morris A" first="Andrew D." last="Morris">Andrew D. Morris</name><affiliation><nlm:aff id="A154">Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School. Dundee, DD1 9SY</nlm:aff></affiliation></author><author><name sortKey="Nieminen, Markku S" sort="Nieminen, Markku S" uniqKey="Nieminen M" first="Markku S." last="Nieminen">Markku S. Nieminen</name><affiliation><nlm:aff id="A176">Division of Cardiology, Cardiovascular Laboratory, Helsinki University Central Hospital, 00029 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Nj Lstad, Inger" sort="Nj Lstad, Inger" uniqKey="Nj Lstad I" first="Inger" last="Nj Lstad">Inger Nj Lstad</name><affiliation><nlm:aff id="A206">Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A207">Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway</nlm:aff></affiliation></author><author><name sortKey="Ohlsson, Claes" sort="Ohlsson, Claes" uniqKey="Ohlsson C" first="Claes" last="Ohlsson">Claes Ohlsson</name><affiliation><nlm:aff id="A83">Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Oldehinkel, Albertine J" sort="Oldehinkel, Albertine J" uniqKey="Oldehinkel A" first="Albertine J." last="Oldehinkel">Albertine J. Oldehinkel</name><affiliation><nlm:aff id="A208">Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Ouwehand, Willem H" sort="Ouwehand, Willem H" uniqKey="Ouwehand W" first="Willem H." last="Ouwehand">Willem H. Ouwehand</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A87">NIHR Cambridge Biomedical Research Centre, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A164">Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A165">NHS Blood and Transplant, Cambridge Centre, Cambridge, CB2 0PT, UK</nlm:aff></affiliation></author><author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J." last="Palmer">Lyle J. Palmer</name><affiliation><nlm:aff id="A36">Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research. Toronto, Canada, M5G 1L7</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Toronto, Canada, M5G 1X5</nlm:aff></affiliation></author><author><name sortKey="Penninx, Brenda" sort="Penninx, Brenda" uniqKey="Penninx B" first="Brenda" last="Penninx">Brenda Penninx</name><affiliation><nlm:aff id="A209">Department of Psychiatry, University Medical Centre Groningen, 9713 GZ Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Power, Chris" sort="Power, Chris" uniqKey="Power C" first="Chris" last="Power">Chris Power</name><affiliation><nlm:aff id="A114">Centre For Paediatric Epidemiolgy and Biostatistics/MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Province, Michael A" sort="Province, Michael A" uniqKey="Province M" first="Michael A." last="Province">Michael A. Province</name><affiliation><nlm:aff id="A7">Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name><affiliation><nlm:aff id="A57">Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A210">Departments of Epidemiology, Medicine and Health Services, University of Washington, Seattle, Washington 98195, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A211">Group Health Research Institute, Group Health, Seattle, Washington 98101, USA</nlm:aff></affiliation></author><author><name sortKey="Qi, Lu" sort="Qi, Lu" uniqKey="Qi L" first="Lu" last="Qi">Lu Qi</name><affiliation><nlm:aff id="A23">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Rauramaa, Rainer" sort="Rauramaa, Rainer" uniqKey="Rauramaa R" first="Rainer" last="Rauramaa">Rainer Rauramaa</name><affiliation><nlm:aff id="A130">Kuopio Research Institute of Exercise Medicine, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A212">Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name><affiliation><nlm:aff id="A70">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts 02215, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A94">Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Ripatti, Samuli" sort="Ripatti, Samuli" uniqKey="Ripatti S" first="Samuli" last="Ripatti">Samuli Ripatti</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A40">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation><nlm:aff id="A127">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, 00271, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name><affiliation><nlm:aff id="A213">Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, LE3 9QP, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A214">Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, LE3 9QP, UK</nlm:aff></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation><nlm:aff id="A65">Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A82">LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="S Rensen, Thorkild I A" sort="S Rensen, Thorkild I A" uniqKey="S Rensen T" first="Thorkild I. A." last="S Rensen">Thorkild I. A. S Rensen</name><affiliation><nlm:aff id="A215">Institute of Preventive Medicine, Bispebjerg University Hospital, Copenhagen, and Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D." last="Spector">Timothy D. Spector</name><affiliation><nlm:aff id="A58">Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><nlm:aff id="A31">deCODE Genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A216">Faculty of Medicine, University of Iceland, 101 Reykjavík, Iceland</nlm:aff></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name><affiliation><nlm:aff id="A179">Department of Medicine, University of Leipzig, 04103 Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A180">University of Leipzig, IFB Adiposity Diseases, Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Tuomilehto, Jaakko" sort="Tuomilehto, Jaakko" uniqKey="Tuomilehto J" first="Jaakko" last="Tuomilehto">Jaakko Tuomilehto</name><affiliation><nlm:aff id="A133">National Institute for Health and Welfare, Diabetes Prevention Unit, 00271 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A217">Red RECAVA Grupo RD06/0014/0015, Hospital Universitario La Paz, 28046 Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A218">Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria</nlm:aff></affiliation><affiliation><nlm:aff id="A219">South Ostrobothnia Central Hospital, 60220 Seinajoki, Finland</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G." last="Uitterlinden">André G. Uitterlinden</name><affiliation><nlm:aff id="A35">Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A60">Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Uusitupa, Matti" sort="Uusitupa, Matti" uniqKey="Uusitupa M" first="Matti" last="Uusitupa">Matti Uusitupa</name><affiliation><nlm:aff id="A220">Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A221">Research Unit, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation><nlm:aff id="A104">Department of Genetics, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A139">Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:aff id="A185">Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, 1011 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name><affiliation><nlm:aff id="A222">Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A11">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name><affiliation><nlm:aff id="A41">Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Oxford, OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H.-Erich" last="Wichmann">H.-Erich Wichmann</name><affiliation><nlm:aff id="A223">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A224">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A225">Klinikum Grosshadern, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="A93">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</nlm:aff></affiliation></author><author><name sortKey="Abecasis, Goncalo R" sort="Abecasis, Goncalo R" uniqKey="Abecasis G" first="Goncalo R." last="Abecasis">Goncalo R. Abecasis</name><affiliation><nlm:aff id="A14">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Assimes, Themistocles L" sort="Assimes, Themistocles L" uniqKey="Assimes T" first="Themistocles L." last="Assimes">Themistocles L. Assimes</name><affiliation><nlm:aff id="A226">Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA</nlm:aff></affiliation></author><author><name sortKey="Barroso, Ines" sort="Barroso, Ines" uniqKey="Barroso I" first="Inês" last="Barroso">Inês Barroso</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A227">University of Cambridge Metabolic Research Labs, Institute of Metabolic Science Addenbrooke’s Hospital, CB2 OQQ, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Boehnke, Michael" sort="Boehnke, Michael" uniqKey="Boehnke M" first="Michael" last="Boehnke">Michael Boehnke</name><affiliation><nlm:aff id="A14">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Borecki, Ingrid B" sort="Borecki, Ingrid B" uniqKey="Borecki I" first="Ingrid B." last="Borecki">Ingrid B. Borecki</name><affiliation><nlm:aff id="A7">Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name><affiliation><nlm:aff id="A6">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S." last="Fox">Caroline S. Fox</name><affiliation><nlm:aff id="A228">Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham Heart Study, Framingham, Massachusetts 01702, USA</nlm:aff></affiliation></author><author><name sortKey="Frayling, Timothy" sort="Frayling, Timothy" uniqKey="Frayling T" first="Timothy" last="Frayling">Timothy Frayling</name><affiliation><nlm:aff id="A22">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, EX1 2LU, UK</nlm:aff></affiliation></author><author><name sortKey="Groop, Leif C" sort="Groop, Leif C" uniqKey="Groop L" first="Leif C." last="Groop">Leif C. Groop</name><affiliation><nlm:aff id="A229">Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, 20502 Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Haritunian, Talin" sort="Haritunian, Talin" uniqKey="Haritunian T" first="Talin" last="Haritunian">Talin Haritunian</name><affiliation><nlm:aff id="A230">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA</nlm:aff></affiliation></author><author><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M." last="Heid">Iris M. Heid</name><affiliation><nlm:aff id="A21">Public Health and Gender Studies, Institute of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A223">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hunter, David" sort="Hunter, David" uniqKey="Hunter D" first="David" last="Hunter">David Hunter</name><affiliation><nlm:aff id="A23">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Kaplan, Robert C" sort="Kaplan, Robert C" uniqKey="Kaplan R" first="Robert C." last="Kaplan">Robert C. Kaplan</name><affiliation><nlm:aff id="A231">Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA</nlm:aff></affiliation></author><author><name sortKey="Karpe, Fredrik" sort="Karpe, Fredrik" uniqKey="Karpe F" first="Fredrik" last="Karpe">Fredrik Karpe</name><affiliation><nlm:aff id="A163">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A232">Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Old Road Headington, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Moffatt, Miriam" sort="Moffatt, Miriam" uniqKey="Moffatt M" first="Miriam" last="Moffatt">Miriam Moffatt</name><affiliation><nlm:aff id="A97">National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK</nlm:aff></affiliation></author><author><name sortKey="Mohlke, Karen L" sort="Mohlke, Karen L" uniqKey="Mohlke K" first="Karen L." last="Mohlke">Karen L. Mohlke</name><affiliation><nlm:aff id="A10">Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA</nlm:aff></affiliation></author><author><name sortKey="O Onnell, Jeffrey R" sort="O Onnell, Jeffrey R" uniqKey="O Onnell J" first="Jeffrey R." last="O Onnell">Jeffrey R. O Onnell</name><affiliation><nlm:aff id="A233">Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</nlm:aff></affiliation></author><author><name sortKey="Pawitan, Yudi" sort="Pawitan, Yudi" uniqKey="Pawitan Y" first="Yudi" last="Pawitan">Yudi Pawitan</name><affiliation><nlm:aff id="A3">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Schadt, Eric E" sort="Schadt, Eric E" uniqKey="Schadt E" first="Eric E." last="Schadt">Eric E. Schadt</name><affiliation><nlm:aff id="A234">Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1498, New York, NY 10029-6574 USA</nlm:aff></affiliation><affiliation><nlm:aff id="A235">Institute of Genomics and Multiscale Biology, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1498, New York, NY 10029-6574 USA</nlm:aff></affiliation></author><author><name sortKey="Schlessinger, David" sort="Schlessinger, David" uniqKey="Schlessinger D" first="David" last="Schlessinger">David Schlessinger</name><affiliation><nlm:aff id="A236">Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224, USA</nlm:aff></affiliation></author><author><name sortKey="Steinthorsdottir, Valgerdur" sort="Steinthorsdottir, Valgerdur" uniqKey="Steinthorsdottir V" first="Valgerdur" last="Steinthorsdottir">Valgerdur Steinthorsdottir</name><affiliation><nlm:aff id="A31">deCODE Genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P." last="Strachan">David P. Strachan</name><affiliation><nlm:aff id="A237">Division of Population Health Sciences and Education, St George’s, University of London, London, SW17 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation><nlm:aff id="A31">deCODE Genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A216">Faculty of Medicine, University of Iceland, 101 Reykjavík, Iceland</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A35">Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation><affiliation><nlm:aff id="A238">Center of Medical Systems Biology, Leiden University Medical Center, 2333 ZC Leiden, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Visscher, Peter M" sort="Visscher, Peter M" uniqKey="Visscher P" first="Peter M." last="Visscher">Peter M. Visscher</name><affiliation><nlm:aff id="A26">The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A32">University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia</nlm:aff></affiliation></author><author><name sortKey="Di Blasio, Anna Maria" sort="Di Blasio, Anna Maria" uniqKey="Di Blasio A" first="Anna Maria" last="Di Blasio">Anna Maria Di Blasio</name><affiliation><nlm:aff id="A13">Molecular Biology Department, Istituto Auxologico Italiano, Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N." last="Hirschhorn">Joel N. Hirschhorn</name><affiliation><nlm:aff id="A15">Divisions of Genetics and Endocrinology and Center for Basic and Translational Obesity Research, Children’s Hospital, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Lindgren, Cecilia M" sort="Lindgren, Cecilia M" uniqKey="Lindgren C" first="Cecilia M." last="Lindgren">Cecilia M. Lindgren</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Morris, Andrew P" sort="Morris, Andrew P" uniqKey="Morris A" first="Andrew P." last="Morris">Andrew P. Morris</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Meyre, David" sort="Meyre, David" uniqKey="Meyre D" first="David" last="Meyre">David Meyre</name><affiliation><nlm:aff id="A55">University Lille Nord de France, 59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A56">CNRS UMR8199-IBL-Institut Pasteur de Lille, F-59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A239">Department of Clinical Epidemiology and Biostatistics, McMasterUniversity, Hamilton, Ontario L8S 4L8, Canada</nlm:aff></affiliation></author><author><name sortKey="Scherag, Andre" sort="Scherag, Andre" uniqKey="Scherag A" first="André" last="Scherag">André Scherag</name><affiliation><nlm:aff id="A67">Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital of Essen, University of Duisburg-Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I." last="Mccarthy">Mark I. Mccarthy</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A163">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A232">Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Old Road Headington, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Speliotes, Elizabeth K" sort="Speliotes, Elizabeth K" uniqKey="Speliotes E" first="Elizabeth K." last="Speliotes">Elizabeth K. Speliotes</name><affiliation><nlm:aff id="A240">Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A241">Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="North, Kari E" sort="North, Kari E" uniqKey="North K" first="Kari E." last="North">Kari E. North</name><affiliation><nlm:aff id="A8">Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, USA</nlm:aff></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J. F." last="Loos">Ruth J. F. Loos</name><affiliation><nlm:aff id="A11">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A242">The Charles Bronfman Institute of Personalized Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A243">The Mindich Child Health and Development Institute, Mount Sinai School of Medicine, New York, NY 10029, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A244">Department of Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA</nlm:aff></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation><nlm:aff id="A2">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Approaches exploiting extremes of the trait distribution may reveal novel loci for common traits, but it is unknown whether such loci are generalizable to the general population. In a genome-wide search for loci associated with upper vs. lower 5<sup>th</sup> percentiles of body mass index, height and waist-hip ratio, as well as clinical classes of obesity including up to 263,407 European individuals, we identified four new loci (<italic>IGFBP4, H6PD, RSRC1, PPP2R2A</italic>) influencing height detected in the tails and seven new loci (<italic>HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3, ZZZ3</italic>) for clinical classes of obesity. 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<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id><journal-id journal-id-type="pubmed-jr-id">2419</journal-id><journal-id journal-id-type="nlm-ta">Nat Genet</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Genet.</journal-id><journal-title-group><journal-title>Nature genetics</journal-title></journal-title-group><issn pub-type="ppub">1061-4036</issn><issn pub-type="epub">1546-1718</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23563607</article-id><article-id pub-id-type="pmc">3973018</article-id><article-id pub-id-type="doi">10.1038/ng.2606</article-id><article-id pub-id-type="manuscript">NIHMS536922</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Berndt</surname><given-names>Sonja I.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib 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contrib-type="author"><name><surname>Ferreira</surname><given-names>Teresa</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Gentilini</surname><given-names>Davide</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Jackson</surname><given-names>Anne U.</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Luan</surname><given-names>Jian’an</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Randall</surname><given-names>Joshua C.</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Vedantam</surname><given-names>Sailaja</given-names></name><xref ref-type="aff" rid="A15">15</xref><xref ref-type="aff" rid="A16">16</xref><xref ref-type="aff" 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contrib-type="author"><name><surname>Watkins</surname><given-names>Hugh</given-names></name><xref ref-type="aff" rid="A41">41</xref></contrib><contrib contrib-type="author"><name><surname>Wichmann</surname><given-names>H.-Erich</given-names></name><xref ref-type="aff" rid="A223">223</xref><xref ref-type="aff" rid="A224">224</xref><xref ref-type="aff" rid="A225">225</xref></contrib><contrib contrib-type="author"><name><surname>Wilson</surname><given-names>James F.</given-names></name><xref ref-type="aff" rid="A93">93</xref></contrib><contrib contrib-type="author"><name><surname>Abecasis</surname><given-names>Goncalo R.</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Assimes</surname><given-names>Themistocles L.</given-names></name><xref ref-type="aff" rid="A226">226</xref></contrib><contrib contrib-type="author"><name><surname>Barroso</surname><given-names>Inês</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A227">227</xref></contrib><contrib contrib-type="author"><name><surname>Boehnke</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Borecki</surname><given-names>Ingrid B.</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Deloukas</surname><given-names>Panos</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Fox</surname><given-names>Caroline S.</given-names></name><xref ref-type="aff" rid="A228">228</xref></contrib><contrib contrib-type="author"><name><surname>Frayling</surname><given-names>Timothy</given-names></name><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Groop</surname><given-names>Leif C.</given-names></name><xref ref-type="aff" rid="A229">229</xref></contrib><contrib contrib-type="author"><name><surname>Haritunian</surname><given-names>Talin</given-names></name><xref ref-type="aff" rid="A230">230</xref></contrib><contrib contrib-type="author"><name><surname>Heid</surname><given-names>Iris M.</given-names></name><xref ref-type="aff" rid="A21">21</xref><xref ref-type="aff" rid="A223">223</xref></contrib><contrib contrib-type="author"><name><surname>Hunter</surname><given-names>David</given-names></name><xref ref-type="aff" rid="A23">23</xref><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Kaplan</surname><given-names>Robert C.</given-names></name><xref ref-type="aff" rid="A231">231</xref></contrib><contrib contrib-type="author"><name><surname>Karpe</surname><given-names>Fredrik</given-names></name><xref ref-type="aff" rid="A163">163</xref><xref ref-type="aff" rid="A232">232</xref></contrib><contrib contrib-type="author"><name><surname>Moffatt</surname><given-names>Miriam</given-names></name><xref ref-type="aff" rid="A97">97</xref></contrib><contrib contrib-type="author"><name><surname>Mohlke</surname><given-names>Karen L.</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>O’Connell</surname><given-names>Jeffrey R.</given-names></name><xref ref-type="aff" rid="A233">233</xref></contrib><contrib contrib-type="author"><name><surname>Pawitan</surname><given-names>Yudi</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Schadt</surname><given-names>Eric E.</given-names></name><xref ref-type="aff" rid="A234">234</xref><xref ref-type="aff" rid="A235">235</xref></contrib><contrib contrib-type="author"><name><surname>Schlessinger</surname><given-names>David</given-names></name><xref ref-type="aff" rid="A236">236</xref></contrib><contrib contrib-type="author"><name><surname>Steinthorsdottir</surname><given-names>Valgerdur</given-names></name><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>Strachan</surname><given-names>David P.</given-names></name><xref ref-type="aff" rid="A237">237</xref></contrib><contrib contrib-type="author"><name><surname>Thorsteinsdottir</surname><given-names>Unnur</given-names></name><xref ref-type="aff" rid="A31">31</xref><xref ref-type="aff" rid="A216">216</xref></contrib><contrib contrib-type="author"><name><surname>van Duijn</surname><given-names>Cornelia M.</given-names></name><xref ref-type="aff" rid="A35">35</xref><xref ref-type="aff" rid="A61">61</xref><xref ref-type="aff" rid="A238">238</xref></contrib><contrib contrib-type="author"><name><surname>Visscher</surname><given-names>Peter M.</given-names></name><xref ref-type="aff" rid="A26">26</xref><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Di Blasio</surname><given-names>Anna Maria</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Hirschhorn</surname><given-names>Joel N.</given-names></name><xref ref-type="aff" rid="A15">15</xref><xref ref-type="aff" rid="A16">16</xref><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Lindgren</surname><given-names>Cecilia M.</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Morris</surname><given-names>Andrew P.</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Meyre</surname><given-names>David</given-names></name><xref ref-type="aff" rid="A55">55</xref><xref ref-type="aff" rid="A56">56</xref><xref ref-type="aff" rid="A239">239</xref></contrib><contrib contrib-type="author"><name><surname>Scherag</surname><given-names>André</given-names></name><xref ref-type="aff" rid="A67">67</xref></contrib><contrib contrib-type="author"><name><surname>McCarthy</surname><given-names>Mark I.</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A163">163</xref><xref ref-type="aff" rid="A232">232</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Speliotes</surname><given-names>Elizabeth K.</given-names></name><xref ref-type="aff" rid="A240">240</xref><xref ref-type="aff" rid="A241">241</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>North</surname><given-names>Kari E.</given-names></name><xref ref-type="aff" rid="A8">8</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Loos</surname><given-names>Ruth J.F.</given-names></name><xref ref-type="aff" rid="A11">11</xref><xref ref-type="aff" rid="A242">242</xref><xref ref-type="aff" rid="A243">243</xref><xref ref-type="aff" rid="A244">244</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Ingelsson</surname><given-names>Erik</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA</aff><aff id="A2"><label>2</label>Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden</aff><aff id="A3"><label>3</label>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</aff><aff id="A4"><label>4</label>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</aff><aff id="A5"><label>5</label>Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</aff><aff id="A6"><label>6</label>Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</aff><aff id="A7"><label>7</label>Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA</aff><aff id="A8"><label>8</label>Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, USA</aff><aff id="A9"><label>9</label>Center for Observational Research, Amgen, Thousands Oaks, CA, 91320</aff><aff id="A10"><label>10</label>Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA</aff><aff id="A11"><label>11</label>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</aff><aff id="A12"><label>12</label>Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia</aff><aff id="A13"><label>13</label>Molecular Biology Department, Istituto Auxologico Italiano, Milano, Italy</aff><aff id="A14"><label>14</label>Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</aff><aff id="A15"><label>15</label>Divisions of Genetics and Endocrinology and Center for Basic and Translational Obesity Research, Children’s Hospital, Boston, Massachusetts 02115, USA</aff><aff id="A16"><label>16</label>Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA</aff><aff id="A17"><label>17</label>Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA</aff><aff id="A18"><label>18</label>Department of Internal Medicine (Cardiovascular), University of Michigan, Ann Arbor, MI 48109, USA</aff><aff id="A19"><label>19</label>Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA</aff><aff id="A20"><label>20</label>Department of Computational Medicine and Bioinformatics, University of Michigan, MI 48109, USA</aff><aff id="A21"><label>21</label>Public Health and Gender Studies, Institute of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany</aff><aff id="A22"><label>22</label>Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, EX1 2LU, UK</aff><aff id="A23"><label>23</label>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA</aff><aff id="A24"><label>24</label>Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA</aff><aff id="A25"><label>25</label>Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia 30322, USA</aff><aff id="A26"><label>26</label>The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia</aff><aff id="A27"><label>27</label>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA</aff><aff id="A28"><label>28</label>Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA</aff><aff id="A29"><label>29</label>Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA</aff><aff id="A30"><label>30</label>Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114</aff><aff id="A31"><label>31</label>deCODE Genetics, 101 Reykjavik, Iceland</aff><aff id="A32"><label>32</label>University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia</aff><aff id="A33"><label>33</label>Queensland Institute of Medical Research, Brisbane 4029, Australia</aff><aff id="A34"><label>34</label>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</aff><aff id="A35"><label>35</label>Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</aff><aff id="A36"><label>36</label>Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research. Toronto, Canada, M5G 1L7</aff><aff id="A37"><label>37</label>Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Toronto, Canada, M5G 1X5</aff><aff id="A38"><label>38</label>Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia 6009, Australia</aff><aff id="A39"><label>39</label>Department of Internal Medicine, VU University Medical Centre, Amsterdam, The Netherlands</aff><aff id="A40"><label>40</label>National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</aff><aff id="A41"><label>41</label>Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Oxford, OX3 7BN, UK</aff><aff id="A42"><label>42</label>Department of Biological Psychology, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands</aff><aff id="A43"><label>43</label>MRC Human Genetics Unit, MRC Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, UK</aff><aff id="A44"><label>44</label>Institute of Medical Biometry and Epidemiology, University of Marburg, 35037 Marburg, Germany</aff><aff id="A45"><label>45</label>Department of Immunology, Genetics and Pathology, Uppsala University, Sweden</aff><aff id="A46"><label>46</label>Uppsala Clinical Research Center, Uppsala university hospital, Sweden</aff><aff id="A47"><label>47</label>Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK</aff><aff id="A48"><label>48</label>Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK</aff><aff id="A49"><label>49</label>LURIC Study nonprofit LLC, Freiburg, Germany</aff><aff id="A50"><label>50</label>Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany</aff><aff id="A51"><label>51</label>Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, 23562 Lübeck, Germany</aff><aff id="A52"><label>52</label>Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland</aff><aff id="A53"><label>53</label>Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland</aff><aff id="A54"><label>54</label>Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria</aff><aff id="A55"><label>55</label>University Lille Nord de France, 59000 Lille, France</aff><aff id="A56"><label>56</label>CNRS UMR8199-IBL-Institut Pasteur de Lille, F-59000 Lille, France</aff><aff id="A57"><label>57</label>Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA</aff><aff id="A58"><label>58</label>Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, UK</aff><aff id="A59"><label>59</label>School of Social and Community Medicine, University of Bristol, UK</aff><aff id="A60"><label>60</label>Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</aff><aff id="A61"><label>61</label>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</aff><aff id="A62"><label>62</label>Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany</aff><aff id="A63"><label>63</label>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology and Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</aff><aff id="A64"><label>64</label>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA</aff><aff id="A65"><label>65</label>Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands</aff><aff id="A66"><label>66</label>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, BS8 2BN, UK</aff><aff id="A67"><label>67</label>Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital of Essen, University of Duisburg-Essen, Essen, Germany</aff><aff id="A68"><label>68</label>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</aff><aff id="A69"><label>69</label>Universität zu Lübeck, Medizinische Klinik II, 23538 Lübeck, Germany</aff><aff id="A70"><label>70</label>Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts 02215, USA</aff><aff id="A71"><label>71</label>Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Lund University, Malmö, Sweden</aff><aff id="A72"><label>72</label>Department of Public Health & Clinical Medicine, Umeå University, Umeå, Sweden</aff><aff id="A73"><label>73</label>Department of Odontology, Umeå University, Sweden</aff><aff id="A74"><label>74</label>Icelandic Heart Association, Kopavogur, Iceland</aff><aff id="A75"><label>75</label>Department of Medicine, University of Iceland, Reykjavik, Iceland</aff><aff id="A76"><label>76</label>Atherosclerosis Research Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden</aff><aff id="A77"><label>77</label>Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, 17487 Greifswald, Germany</aff><aff id="A78"><label>78</label>Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands</aff><aff id="A79"><label>79</label>Heart Failure Research Centre, Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, the Netherlands</aff><aff id="A80"><label>80</label>Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK</aff><aff id="A81"><label>81</label>Department of Endocrinology, University Medical Center Groningen, University of Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands</aff><aff id="A82"><label>82</label>LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, The Netherlands</aff><aff id="A83"><label>83</label>Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden</aff><aff id="A84"><label>84</label>Hudson Alpha Institute for Biotechnology, Huntsville, Alabama 35806, USA</aff><aff id="A85"><label>85</label>Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, The Netherlands</aff><aff id="A86"><label>86</label>Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Finland</aff><aff id="A87"><label>87</label>NIHR Cambridge Biomedical Research Centre, Cambridge, UK</aff><aff id="A88"><label>88</label>Division of Epidemiology, Multidisciplinary Cardiovascular Research Centre (MCRC), Leeds Institute of Genetics, Health and Therapeutics (LIGHT), University of Leeds, Leeds LS2 9JT, UK</aff><aff id="A89"><label>89</label>PathWest Laboratory of Western Australia, Department of Molecular Genetics, J Block, QEII Medical Centre, Nedlands, Western Australia 6009, Australia</aff><aff id="A90"><label>90</label>Department of Surgery and Pathology, University of Western Australia, Nedlands, Australia, 6009</aff><aff id="A91"><label>91</label>Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</aff><aff id="A92"><label>92</label>Dipartimento di Medicina Sperimentale. Università degli Studi Milano-Bicocca, Monza, Italy</aff><aff id="A93"><label>93</label>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</aff><aff id="A94"><label>94</label>Harvard Medical School, Boston, Massachusetts 02115, USA</aff><aff id="A95"><label>95</label>British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, G12 8TA, UK</aff><aff id="A96"><label>96</label>University of Dundee, Ninewells Hospital &Medical School, Dundee, DD1 9SY, UK</aff><aff id="A97"><label>97</label>National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK</aff><aff id="A98"><label>98</label>Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A99"><label>99</label>Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands</aff><aff id="A100"><label>100</label>Istituto di Ricerca Genetica e Biomedicadel del CNR, Monserrato, 09042, Cagliari, Italy</aff><aff id="A101"><label>101</label>Department of Dietetics-Nutrition, Harokopio University, 70 El. Venizelou Str, Athens, Greece</aff><aff id="A102"><label>102</label>Epidemiology and Preventive Medicine Research Center, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy</aff><aff id="A103"><label>103</label>Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, France</aff><aff id="A104"><label>104</label>Department of Genetics, University Medical Center Groningen, University of Groningen, The Netherlands</aff><aff id="A105"><label>105</label>University of Milan, Department of Health Sciences, Ospedale San Paolo, 20139 Milano, Italy</aff><aff id="A106"><label>106</label>University of Chicago, Chicago, Illinois 60637, USA</aff><aff id="A107"><label>107</label>Northshore University HealthSystem, Evanston, Illinois 60201, USA</aff><aff id="A108"><label>108</label>Research Unit for Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="A109"><label>109</label>Division of Cardiovascular and Neuronal Remodelling, Multidisciplinary Cardiovascular Research Centre, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, UK</aff><aff id="A110"><label>110</label>Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, 90014 Oulu, Finland</aff><aff id="A111"><label>111</label>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA</aff><aff id="A112"><label>112</label>Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63108, USA</aff><aff id="A113"><label>113</label>Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, 45147 Essen, Germany</aff><aff id="A114"><label>114</label>Centre For Paediatric Epidemiolgy and Biostatistics/MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London, UK</aff><aff id="A115"><label>115</label>Division of Research, Kaiser Permanente Northern California, Oakland, California 94612, USA</aff><aff id="A116"><label>116</label>Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA</aff><aff id="A117"><label>117</label>Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden</aff><aff id="A118"><label>118</label>National Institute for Health and Welfare, Department of Chronic Disease Prevention, Population Studies Unit, 20720 Turku, Finland</aff><aff id="A119"><label>119</label>Department of Clinical Physiology, University of Tampere and Tampere University Hospital, 33520 Tampere, Finland</aff><aff id="A120"><label>120</label>Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</aff><aff id="A121"><label>121</label>Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</aff><aff id="A122"><label>122</label>Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA</aff><aff id="A123"><label>123</label>UKCRC Centre of Excellence for Public Health (NI) Queens University, Belfast</aff><aff id="A124"><label>124</label>Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge CB2 2SR, UK</aff><aff id="A125"><label>125</label>Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, UK</aff><aff id="A126"><label>126</label>Department of Internal Medicine II – Cardiology, University of Ulm Medical Center, Ulm, Germany</aff><aff id="A127"><label>127</label>National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, 00271, Helsinki, Finland</aff><aff id="A128"><label>128</label>Department of Medicine, University of Eastern Finland, Kuopio Campus and Kuopio University Hospital, 70210 Kuopio, Finland</aff><aff id="A129"><label>129</label>Finnish Institute of Occupational Health, 90220 Oulu, Finland</aff><aff id="A130"><label>130</label>Kuopio Research Institute of Exercise Medicine, Kuopio, Finland</aff><aff id="A131"><label>131</label>Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA</aff><aff id="A132"><label>132</label>Department of Medical Sciences, Uppsala University, Akademiska sjukhuset, 751 85 Uppsala, Sweden</aff><aff id="A133"><label>133</label>National Institute for Health and Welfare, Diabetes Prevention Unit, 00271 Helsinki, Finland</aff><aff id="A134"><label>134</label>Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore</aff><aff id="A135"><label>135</label>Department of Internal Medicine, Istituto Auxologico Italiano, Verbania, Italy</aff><aff id="A136"><label>136</label>Transplantation Laboratory, Haartman Institute, University of Helsinki, 00014, Helsinki, Finland</aff><aff id="A137"><label>137</label>Università Vita-Salute San Raffaele, Chair of Nephrology San Raffaele Scientific Institute, OU Nephrology and Dialysis, 20132 Milan, Italy</aff><aff id="A138"><label>138</label>Synlab Academy, Mannheim, Germany</aff><aff id="A139"><label>139</label>Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands</aff><aff id="A140"><label>140</label>Departments of Biostatistics, University of Washington, Seattle, Washington 98195, USA</aff><aff id="A141"><label>141</label>Genetics Division, GlaxoSmithKline, King of Prussia, Pennsylvania 19406, USA</aff><aff id="A142"><label>142</label>Institute of Human Genetics, University of Bonn, Bonn, Germany</aff><aff id="A143"><label>143</label>Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</aff><aff id="A144"><label>144</label>School of Population Health, The University of Western Australia, Nedlands WA 6009, Australia</aff><aff id="A145"><label>145</label>Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Australia, 6009</aff><aff id="A146"><label>146</label>Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia</aff><aff id="A147"><label>147</label>Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen</aff><aff id="A148"><label>148</label>MRC Harwell, Harwell, UK</aff><aff id="A149"><label>149</label>Department of Statistics, University of Oxford, Oxford OX1 3TG, UK</aff><aff id="A150"><label>150</label>Department of Public Health, Section of Epidemiology, Aarhus University, Denmark</aff><aff id="A151"><label>151</label>MRC Unit for Lifelong Health & Ageing, London, UK</aff><aff id="A152"><label>152</label>Department of Clinical Genetics, Erasmus MC, Rotterdam, 3015GE, The Netherlands</aff><aff id="A153"><label>153</label>Centre for Medical Systems Biology & Netherlands Consortium on Healthy Aging, Leiden, the Netherlands</aff><aff id="A154"><label>154</label>Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School. Dundee, DD1 9SY</aff><aff id="A155"><label>155</label>Illumina Inc. Cambridge</aff><aff id="A156"><label>156</label>Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="A157"><label>157</label>Munich Heart Alliance, Munich, Germany</aff><aff id="A158"><label>158</label>Faculty of Medicine, University of Split, Croatia</aff><aff id="A159"><label>159</label>National Institute for Health and Welfare, 90101 Oulu, Finland</aff><aff id="A160"><label>160</label>Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, 39100, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany</aff><aff id="A161"><label>161</label>Department of Neurology, General Central Hospital, Bolzano, Italy</aff><aff id="A162"><label>162</label>Department of Neurology, University of Lübeck, Lübeck, Germany</aff><aff id="A163"><label>163</label>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</aff><aff id="A164"><label>164</label>Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK</aff><aff id="A165"><label>165</label>NHS Blood and Transplant, Cambridge Centre, Cambridge, CB2 0PT, UK</aff><aff id="A166"><label>166</label>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520 Turku, Finland</aff><aff id="A167"><label>167</label>The Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, 20520 Turku, Finland</aff><aff id="A168"><label>168</label>MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK</aff><aff id="A169"><label>169</label>Finnish Diabetes Association, Kirjoniementie 15, 33680, Tampere, Finland</aff><aff id="A170"><label>170</label>Pirkanmaa Hospital District, Tampere, Finland</aff><aff id="A171"><label>171</label>South Karelia Central Hospital, 53130 Lappeenranta, Finland</aff><aff id="A172"><label>172</label>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany</aff><aff id="A173"><label>173</label>Institute for Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany</aff><aff id="A174"><label>174</label>Deutsches Zentrum für Herz-Kreislaufforschung e. V. (DZHK), Universität zu Lübeck, 23538 Lübeck, Germany</aff><aff id="A175"><label>175</label>Azienda ospedaliera di Desio e Vimercate, Milano, Italy</aff><aff id="A176"><label>176</label>Division of Cardiology, Cardiovascular Laboratory, Helsinki University Central Hospital, 00029 Helsinki, Finland</aff><aff id="A177"><label>177</label>University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland</aff><aff id="A178"><label>178</label>Klinik und Poliklinik für Innere Medizin II, Universitätklinikum Regensburg, 93053 Regensburg, Germany</aff><aff id="A179"><label>179</label>Department of Medicine, University of Leipzig, 04103 Leipzig, Germany</aff><aff id="A180"><label>180</label>University of Leipzig, IFB Adiposity Diseases, Leipzig, Germany</aff><aff id="A181"><label>181</label>INSERM UMR_S 937, ICAN Institute, Pierre et Marie Curie Medical School, Paris 75013, France</aff><aff id="A182"><label>182</label>Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Centro Cardiologico Monzino, IRCCS, Milan, Italy</aff><aff id="A183"><label>183</label>Department of Human Genetics, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands</aff><aff id="A184"><label>184</label>Department of Medicine, University of Turku and Turku University Hospital, 20520 Turku, Finland</aff><aff id="A185"><label>185</label>Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, 1011 Lausanne, Switzerland</aff><aff id="A186"><label>186</label>Cardiology Group, Frankfurt-Sachsenhausen, Germany</aff><aff id="A187"><label>187</label>Institut Pasteur de Lille, INSERM U744, Université Lille Nord de France, F-59000 Lille, France</aff><aff id="A188"><label>188</label>Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, Ulm, Germany</aff><aff id="A189"><label>189</label>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas 77030, USA</aff><aff id="A190"><label>190</label>Fondazione Filarete, Milano, Italy</aff><aff id="A191"><label>191</label>Department of General Practice and Primary health Care, University of Helsinki, Helsinki, Finland</aff><aff id="A192"><label>192</label>National Institute for Health and Welfare, 00271 Helsinki, Finland</aff><aff id="A193"><label>193</label>Helsinki University Central Hospital, Unit of General Practice, 00280 Helsinki, Finland</aff><aff id="A194"><label>194</label>Department of Nutrition, Harvard School of Public Health, Boston, MA</aff><aff id="A195"><label>195</label>Department of Genomics of Common Disease, School of Public Health, Imperial College London, W12 0NN, London, UK</aff><aff id="A196"><label>196</label>HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway</aff><aff id="A197"><label>197</label>Hannover Unified Biobank, Hannover Medical School, 30625 Hannover, Germany</aff><aff id="A198"><label>198</label>Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, W2 1PG, UK</aff><aff id="A199"><label>199</label>Institute of Health Sciences, University of Oulu, 90014 Oulu, Finland</aff><aff id="A200"><label>200</label>Biocenter Oulu, University of Oulu, 90014 Oulu, Finland</aff><aff id="A201"><label>201</label>Unit of General Practice, Oulu University Hospital, Oulu, Finland</aff><aff id="A202"><label>202</label>Department of Urology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands</aff><aff id="A203"><label>203</label>Comprehensive Cancer Center East, 6501 BG Nijmegen, The Netherlands</aff><aff id="A204"><label>204</label>Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere and Tampere University Hospital, 33520 Tampere, Finland</aff><aff id="A205"><label>205</label>Stanford University School of Medicine, Stanford, California 93405, USA</aff><aff id="A206"><label>206</label>Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway</aff><aff id="A207"><label>207</label>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway</aff><aff id="A208"><label>208</label>Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, The Netherlands</aff><aff id="A209"><label>209</label>Department of Psychiatry, University Medical Centre Groningen, 9713 GZ Groningen, The Netherlands</aff><aff id="A210"><label>210</label>Departments of Epidemiology, Medicine and Health Services, University of Washington, Seattle, Washington 98195, USA</aff><aff id="A211"><label>211</label>Group Health Research Institute, Group Health, Seattle, Washington 98101, USA</aff><aff id="A212"><label>212</label>Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland</aff><aff id="A213"><label>213</label>Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, LE3 9QP, UK</aff><aff id="A214"><label>214</label>Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, LE3 9QP, UK</aff><aff id="A215"><label>215</label>Institute of Preventive Medicine, Bispebjerg University Hospital, Copenhagen, and Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark</aff><aff id="A216"><label>216</label>Faculty of Medicine, University of Iceland, 101 Reykjavík, Iceland</aff><aff id="A217"><label>217</label>Red RECAVA Grupo RD06/0014/0015, Hospital Universitario La Paz, 28046 Madrid, Spain</aff><aff id="A218"><label>218</label>Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria</aff><aff id="A219"><label>219</label>South Ostrobothnia Central Hospital, 60220 Seinajoki, Finland</aff><aff id="A220"><label>220</label>Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Finland</aff><aff id="A221"><label>221</label>Research Unit, Kuopio University Hospital, Kuopio, Finland</aff><aff id="A222"><label>222</label>Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany</aff><aff id="A223"><label>223</label>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="A224"><label>224</label>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</aff><aff id="A225"><label>225</label>Klinikum Grosshadern, Munich, Germany</aff><aff id="A226"><label>226</label>Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA</aff><aff id="A227"><label>227</label>University of Cambridge Metabolic Research Labs, Institute of Metabolic Science Addenbrooke’s Hospital, CB2 OQQ, Cambridge, UK</aff><aff id="A228"><label>228</label>Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham Heart Study, Framingham, Massachusetts 01702, USA</aff><aff id="A229"><label>229</label>Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, 20502 Malmö, Sweden</aff><aff id="A230"><label>230</label>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA</aff><aff id="A231"><label>231</label>Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA</aff><aff id="A232"><label>232</label>Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Old Road Headington, Oxford, OX3 7LJ, UK</aff><aff id="A233"><label>233</label>Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</aff><aff id="A234"><label>234</label>Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1498, New York, NY 10029-6574 USA</aff><aff id="A235"><label>235</label>Institute of Genomics and Multiscale Biology, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1498, New York, NY 10029-6574 USA</aff><aff id="A236"><label>236</label>Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224, USA</aff><aff id="A237"><label>237</label>Division of Population Health Sciences and Education, St George’s, University of London, London, SW17 0RE, UK</aff><aff id="A238"><label>238</label>Center of Medical Systems Biology, Leiden University Medical Center, 2333 ZC Leiden, the Netherlands</aff><aff id="A239"><label>239</label>Department of Clinical Epidemiology and Biostatistics, McMasterUniversity, Hamilton, Ontario L8S 4L8, Canada</aff><aff id="A240"><label>240</label>Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA</aff><aff id="A241"><label>241</label>Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA</aff><aff id="A242"><label>242</label>The Charles Bronfman Institute of Personalized Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA</aff><aff id="A243"><label>243</label>The Mindich Child Health and Development Institute, Mount Sinai School of Medicine, New York, NY 10029, USA</aff><aff id="A244"><label>244</label>Department of Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA</aff><author-notes><corresp id="FN1">Correspondence should be addressed to: Erik Ingelsson, MD, PhD, FAHA, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, P.O Box 281, Solna, SE-171 77 Stockholm, SWEDEN, Phone: +46-8-52482334, fax: +46-8-314975, <email>erik.ingelsson@ki.se</email></corresp><fn id="FN2" fn-type="equal"><label>*</label><p>These authors contributed equally to this work</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>14</day><month>2</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>07</day><month>4</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>02</day><month>4</month><year>2014</year></pub-date><volume>45</volume><issue>5</issue><fpage>501</fpage><lpage>512</lpage><pmc-comment>elocation-id from pubmed: 10.1038/ng.2606</pmc-comment>
<permissions><license xlink:href="http://www.nature.com/authors/editorial_policies/license.html#terms"><license-p>Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:<ext-link ext-link-type="uri" xlink:href="http://www.nature.com/authors/editorial_policies/license.html#terms">http://www.nature.com/authors/editorial_policies/license.html#terms</ext-link></license-p></license></permissions><abstract><p id="P1">Approaches exploiting extremes of the trait distribution may reveal novel loci for common traits, but it is unknown whether such loci are generalizable to the general population. In a genome-wide search for loci associated with upper vs. lower 5<sup>th</sup> percentiles of body mass index, height and waist-hip ratio, as well as clinical classes of obesity including up to 263,407 European individuals, we identified four new loci (<italic>IGFBP4, H6PD, RSRC1, PPP2R2A</italic>) influencing height detected in the tails and seven new loci (<italic>HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3, ZZZ3</italic>) for clinical classes of obesity. Further, we show that there is large overlap in terms of genetic structure and distribution of variants between traits based on extremes and the general population and little etiologic heterogeneity between obesity subgroups.</p></abstract></article-meta></front><body><p id="P2">Twin studies have established a strong heritable component to body mass index (BMI; h<sup>2</sup>~40-70%),<sup><xref rid="R1" ref-type="bibr">1</xref>,<xref rid="R2" ref-type="bibr">2</xref></sup> and height (h<sup>2</sup>~70-90%).<sup><xref rid="R3" ref-type="bibr">3</xref></sup> Previous meta-analyses of genome-wide association studies (GWAS) have identified 36 genetic loci associated with BMI,<sup><xref rid="R4" ref-type="bibr">4</xref>-<xref rid="R6" ref-type="bibr">6</xref></sup> 14 loci with waist-hip ratio adjusted for BMI (WHR) reflecting fat distribution,<sup><xref rid="R7" ref-type="bibr">7</xref>,<xref rid="R8" ref-type="bibr">8</xref></sup> and 180 loci with height<sup><xref rid="R9" ref-type="bibr">9</xref></sup>, and contributed to our understanding of the genetic architecture of complex traits. However, established loci for complex traits only account for a small proportion of trait heritability, as discussed recently.<sup><xref rid="R10" ref-type="bibr">10</xref>,<xref rid="R11" ref-type="bibr">11</xref></sup> Some postulated explanations for this include undiscovered low frequency variants with larger effects, imperfect tagging of causal variants, epistasis, gene-environment interaction, and phenotype heterogeneity. This has led to increasing interest in approaches exploiting extremes of the trait distribution, where there may be less locus heterogeneity, greater genetic contribution, and enrichment for highly penetrant variants. Utilization of extremes has also been proposed to improve cost-efficiency, since effect sizes may be larger, fewer subjects may be needed for genotyping, and a smaller proportion of the variance may be attributable to environmental factors. Indeed, several prior studies have used extreme designs to discovery novel loci for various complex traits, such as obesity and lipid fractions using microarray genotyping<sup><xref rid="R12" ref-type="bibr">12</xref>-<xref rid="R16" ref-type="bibr">16</xref></sup> or sequencing methods.<sup><xref rid="R17" ref-type="bibr">17</xref>-<xref rid="R20" ref-type="bibr">20</xref></sup> However, the few previous studies that have systematically addressed differences between genetic architecture of the overall distribution with extremes for complex traits have been small,<sup><xref rid="R21" ref-type="bibr">21</xref>-<xref rid="R23" ref-type="bibr">23</xref></sup> and hence, it remains largely unknown whether genetic loci affecting the extremes are generalizable to the general population.</p><p id="P3">Studies of extremely obese individuals have reported thirteen loci at or near genome-wide significance (<italic>P</italic><5×10<sup>-7</sup>),<sup><xref rid="R14" ref-type="bibr">14</xref>-<xref rid="R16" ref-type="bibr">16</xref>,<xref rid="R22" ref-type="bibr">22</xref>-<xref rid="R26" ref-type="bibr">26</xref></sup> but not all have shown evidence of association with BMI in the general population.<sup><xref rid="R4" ref-type="bibr">4</xref>,<xref rid="R27" ref-type="bibr">27</xref></sup> For example, variants in <italic>PCSK1</italic> (rs6232) and <italic>PTER</italic> have been convincingly associated with severe obesity,<sup><xref rid="R14" ref-type="bibr">14</xref>,<xref rid="R25" ref-type="bibr">25</xref></sup> but have at best shown nominal evidence of association with BMI in large-scale meta-analyses.<sup><xref rid="R4" ref-type="bibr">4</xref>,<xref rid="R28" ref-type="bibr">28</xref></sup> Although it is possible that other genetic or environmental factors modify the manifestation of these variants producing an extreme phenotype only in selected individuals, it is also conceivable that the extremes are, at least in part, etiologically distinct. Within the extremes of the distribution, there may be etiologically discrete subgroups or enrichment for less common causal variants.<sup><xref rid="R19" ref-type="bibr">19</xref></sup> Although analyzing the full distribution is generally more powerful, in cases where there is heterogeneity, analyzing extremes by case-control design may offer superior power.<sup><xref rid="R29" ref-type="bibr">29</xref></sup></p><p id="P4">The extremes for anthropometric traits, particularly BMI, have been defined in numerous ways, including using tails of the full population distribution (e.g. >95<sup>th</sup> or >97<sup>th</sup> percentile) and absolute cutpoints (e.g. ≥40 kg/m<sup>2</sup>) based on clinical or standard references, and some studies have used a combination of definitions for their discovery and replication. The common denominator for studies addressing ’extremes’ (herein used as a more generic term) is that they have dichotomized the trait distribution and analyzed data using a case-control design. Studies suggest that the percentile cutpoint choice and ascertainment strategy utilized may impact the observed risk and subsequent power;<sup><xref rid="R30" ref-type="bibr">30</xref>,<xref rid="R31" ref-type="bibr">31</xref></sup> however, the consequences of these extreme definitions on discovery and characterization of loci for complex traits have not been systematically evaluated. In the present study, we have used the term ‘tails’ to describe analyses comparing the upper and lower 5<sup>th</sup> percentiles of the trait distributions; ‘clinical classes of obesity’ to describe analyses where controls were subjects with BMI <25 kg/m<sup>2</sup> and cases were defined as BMI ≥25 kg/m<sup>2</sup> for overweight, BMI ≥30 kg/m<sup>2</sup> for obesity class I, BMI ≥35 kg/m<sup>2</sup> for obesity class II, and BMI ≥40kg/m<sup>2</sup> for obesity class III<sup><xref rid="R32" ref-type="bibr">32</xref></sup>; and ‘extremely obese’ to describe studies using different sampling designs for selecting their extremely obese cases and controls.</p><p id="P5">The overall aim of the present study was to use and compare different distribution cutoffs for identification of genetic loci of anthropometric traits. The two specific aims were: 1) to systematically compare findings using these cutoffs with those from the full population distribution, as well as with studies utilizing a different ascertainment strategy; and 2) to draw inferences about the value of these different approaches for sampling within a population-based study. Our focus was primarily on BMI, which is a major risk factor for multiple chronic diseases and of important public health significance,<sup><xref rid="R33" ref-type="bibr">33</xref></sup> but we also examined height and waist-hip ratio adjusted for BMI (WHR; as a measure of body fat distribution) to verify if our findings could be generalized to other traits. To address these aims, we performed a genome-wide search for genetic determinants of the tails (defined as the upper vs. lower 5<sup>th</sup> percentile of the trait distribution) of BMI, height and WHR and for comparison, clinical classes of obesity drawn from populations within the GIANT (Genetic Investigation of ANthropometric Traits) consortium. Association analyses were conducted in a study base (or sampling frame) of up to 168,267 individuals with follow-up of the 273 most significantly associated loci in a study base of up to 109,703 additional individuals. Further, systematic comparisons were conducted to assess differences in genetic inheritance and distribution of risk variants between the extremes and general population for these anthropometric traits.</p><sec sec-type="results" id="S1"><title>Results</title><p id="P6">To first evaluate the contribution of common SNPs to the tails and clinical classes of obesity and discover new loci, we conducted meta-analyses of GWAS of six obesity-related traits (tails of BMI and WHR, overweight, obesity class I, II and III), as well as tails of height, utilizing results for ~2.8 million genotyped or imputed SNPs. Stage 1 analyses included 51 studies with study bases of 158,864 (BMI), 168,267 (height) and 100,605 (WHR) individuals of European ancestry (see <xref rid="SD2" ref-type="supplementary-material">Supplementary Table 1</xref> for number of cases and controls per phenotype; <xref rid="SD2" ref-type="supplementary-material">Supplementary 2-5</xref> for study characteristics). We observed an enrichment of SNPs with small P-values compared to the null distribution for all seven traits (Q-Q plots, <xref rid="SD2" ref-type="supplementary-material">Supplementary Fig. 1-2</xref>). The excess was diminished after exclusion of loci previously established for the overall distributions or extremes of these traits, but some enrichment remained, especially for tails of height and to a lesser extent for overweight, obesity class I and II. In total, 69 loci (defined as separated by at least 1 Mb) were associated at <italic>P</italic><5×10<sup>-8</sup> with at least one trait (<xref rid="SD2" ref-type="supplementary-material">Supplementary Fig. 3-4</xref>).</p><p id="P7">To identify and validate loci for these traits, SNPs for which associations reached <italic>P</italic><5×10<sup>-6</sup> in the stage 1 analyses were taken forward for follow-up (stage 2) in 12 studies with <italic>in silico</italic> GWAS data and 24 studies with Metabochip data with study bases of 109,703 (BMI), 107,740 (height) and 75,220 (WHR) (<xref rid="SD2" ref-type="supplementary-material">Supplementary Tables 1-5</xref>).</p><sec id="S2"><title>BMI-Related Traits</title><p id="P8">Seventeen SNPs were taken forward to stage 2 in up to 4,900 and 4,891 individuals from the upper and lower tails of BMI, respectively. Ten SNPs reached genome-wide significance (<italic>P</italic><5×10<sup>-8</sup>) in the joint meta-analysis of stage 1 and stage 2, but all had been previously identified as loci associated with BMI in the general population.<sup><xref rid="R4" ref-type="bibr">4</xref></sup> A total of 118 SNPs were included in stage 2 for clinical classes of obesity, which included up to 1,162 cases and 22,307 controls for obesity class III, and 65,332 cases and 39,294 controls for overweight. Of the 62 SNPs that showed <italic>P</italic><5×10<sup>-8</sup> in the joint meta-analyses for at least one obesity class (<xref rid="SD2" ref-type="supplementary-material">Supplementary Table 6</xref>), seven were novel, explaining an additional 0.09% of the variability in BMI (<xref rid="SD2" ref-type="supplementary-material">Supplementary Table 7</xref>). These included one locus for overweight (<italic>RPTOR</italic>), three loci for obesity class I (<italic>GNAT2, MRPS33P4, ADCY9</italic>), two loci for obesity class II (<italic>HS6ST3, ZZZ3</italic>), and one locus associated with both overweight and obesity class I (<italic>HNF4G</italic>) (<xref rid="T1" ref-type="table">Table 1</xref>, <xref rid="SD2" ref-type="supplementary-material">Supplementary Fig. 5-7</xref>). Although these loci were identified for specific clinical classes of obesity, all novel loci showed consistent effect direction across the tails of BMI and the other class of obesity, and most <italic>P</italic>-values were significant (<italic>P</italic><0.007, Bonferroni-corrected for 7 SNPs), except for obesity class III and the tails of BMI (presumably due to lower statistical power for these traits; <xref rid="T2" ref-type="table">Table 2</xref>).</p><p id="P9">Among the novel obesity loci, at least four are located near genes of high biological relevance. In particular, rs7503807 for overweight, is located within the regulatory associated protein of the MTOR, complex 1 gene (<italic>RPTOR</italic>), which regulates cell growth in response to nutrient and insulin levels,<sup><xref rid="R34" ref-type="bibr">34</xref></sup> and within 500 kb of the BAI1-associated protein 2 (<italic>BAIAP2</italic>), which encodes a brain-specific angiogenesis inhibitor (BAI1)-binding protein that regulates insulin uptake in the central nervous system. The overweight and obesity class I SNP rs4735692 is located downstream of the hepatocyte nuclear factor 4-gamma gene (<italic>HNF4G</italic>). Mutations in <italic>HNF4A</italic>, a closely related gene that forms a heterodimer with HNF4G to activate gene transcription,<sup><xref rid="R35" ref-type="bibr">35</xref></sup> cause maturity onset diabetes of the young type 1,<sup><xref rid="R36" ref-type="bibr">36</xref></sup> and a common variant near <italic>HNF4A</italic> was found to be associated with type 2 diabetes (T2D) in east Asians.<sup><xref rid="R37" ref-type="bibr">37</xref></sup> The obesity class I SNP rs2531995 is located within adenylate cyclase 9 (<italic>ADCY9</italic>), which catalyzes the formation of cyclic AMP from ATP. This SNP was found to be associated with <italic>ADCY9</italic> expression in several tissue types (<xref rid="SD2" ref-type="supplementary-material">Supplementary Table 8</xref>). Loci near other adenylate cyclase genes have been associated with several T2D-related traits, such as glucose homeostasis and susceptibility to T2D (<italic>ADCY5</italic>).<sup><xref rid="R38" ref-type="bibr">38</xref>,<xref rid="R39" ref-type="bibr">39</xref></sup> The obesity class II SNP rs17024258 is located 207kb from the lipid-related gene sortilin <italic>(SORT1)</italic>, which is expressed in multiple cell types and has been reported to be involved in insulin responsiveness in adipose cells.<sup><xref rid="R40" ref-type="bibr">40</xref></sup> Decreased levels of sortilin have been observed in adipose tissues of morbidly obese humans and mice, and in skeletal muscle of obese mice.<sup><xref rid="R41" ref-type="bibr">41</xref></sup> A more comprehensive summary of the biological relevance of the genes nearest to all novel loci is given in the <xref rid="SD2" ref-type="supplementary-material">Supplementary Note</xref>.</p></sec><sec id="S3"><title>Tails of Height</title><p id="P10">A total of 134 SNPs from stage 1 were taken forward to stage 2 in up to 4,872 and 4,831 individuals from the upper and lower tails of height, respectively. Of the 95 SNPs that reached <italic>P</italic><5×10<sup>-8</sup> in the joint meta-analysis of stage 1 and stage 2 (<xref rid="SD2" ref-type="supplementary-material">Supplementary Table 6</xref>), four novel loci (<italic>IGFBP4, H6PD, RSRC1, PPP2R2A</italic>) were identified for tails of height (<xref rid="T1" ref-type="table">Table 1</xref>, <xref rid="SD2" ref-type="supplementary-material">Supplementary Fig. 8</xref>). The contribution of the four loci to the overall height variability was ≤0.02% (<xref rid="SD2" ref-type="supplementary-material">Supplementary Table 7</xref>).</p><p id="P11">Two of the novel loci are located near genes that seem particularly relevant to height. rs584438 is located approximately 500 bp upstream of <italic>IGFBP4</italic>, which codes for insulin-like growth factor binding protein 4, and is in linkage disequilibrium (r<sup>2</sup>=0.87) with another SNP (rs598892) that results in a synonymous amino acid change in IGFBP4. IGFBP4 binds to IGF1 and IGF2,<sup><xref rid="R42" ref-type="bibr">42</xref></sup> which have an important role in childhood growth. In blood, this same SNP showed a significant association with the expression of <italic>TNS4</italic> (<xref rid="SD2" ref-type="supplementary-material">Supplementary Table 8</xref>), which interacts with beta-catenin,<sup><xref rid="R43" ref-type="bibr">43</xref></sup> a critical component of the canonical Wnt pathway related to bone formation.<sup><xref rid="R44" ref-type="bibr">44</xref></sup> The height SNP rs2362965 lies 285 kb from <italic>SHOX2</italic>, a homolog to the X-linked, pseudoautosomal <italic>SHOX</italic> (short stature homeobox) gene family, which plays a major role in skeletal limb development.</p></sec><sec id="S4"><title>Tails of Waist-Hip Ratio</title><p id="P12">Ten SNPs were taken forward to stage 2 in 3,351 and 3,352 individuals from the upper and lower tails of WHR, respectively. The four SNPs that reached genome-wide significance (<italic>P</italic><5×10<sup>-8</sup>; <xref rid="SD2" ref-type="supplementary-material">Supplementary Table 6</xref>) have been previously identified as WHR loci in the general population.<sup><xref rid="R7" ref-type="bibr">7</xref></sup></p></sec><sec id="S5"><title>Comparisons of novel and known loci on the tails, obesity classes, and full distribution</title><p id="P13">We assessed the impact of our novel loci on the full distribution of these anthropometric traits using data from studies included in stage 1 and stage 2. In the full distribution, evidence of association (<italic>P</italic><0.005, Bonferroni-corrected for 11 SNPs) with consistent effect direction was observed with BMI for all novel obesity-related trait loci and with height for all novel loci identified for tails of height (<xref rid="T2" ref-type="table">Table 2</xref>). None of the loci were associated with WHR, suggesting that these obesity loci are primarily associated with overall adiposity, rather than with fat distribution.</p><p id="P14">Within GIANT, we previously identified 32 loci associated with BMI.<sup><xref rid="R4" ref-type="bibr">4</xref></sup> There is considerable overlap of samples with the current study, so it is not unexpected that we observed that the effects of all established BMI loci were directionally consistent between the prior study of overall BMI and the obesity-related traits in the present study (<xref rid="SD2" ref-type="supplementary-material">Supplementary Table 9</xref>). Twenty-seven out of 32 SNPs were significantly associated with the tails of BMI (P<0.0016, Bonferroni-corrected). Although only half of the SNPs were significantly associated with obesity class 3, presumably due to the smaller sample size and reduced power, the majority of SNPs were significantly associated with obesity class 2 and all with obesity class 1 and overweight.</p></sec><sec id="S6" sec-type="discussion"><title>Impact of ascertainment strategy on discovered and known loci</title><sec id="S7"><title>Effect of our novel loci in other studies of extremely obese</title><p id="P15">Both empirical<sup><xref rid="R16" ref-type="bibr">16</xref></sup> and theoretical work<sup><xref rid="R29" ref-type="bibr">29</xref></sup> has shown that genetic architecture may differ, the more extreme the selection, suggesting that the ascertainment strategy may impact observed results.<sup><xref rid="R31" ref-type="bibr">31</xref></sup> To evaluate impact of ascertainment strategy, we also performed <italic>in silico</italic> look-ups of all SNPs we found to be associated with BMI-related traits in five studies that applied other ascertainment strategies for defining extremely obese (<xref rid="SD2" ref-type="supplementary-material">Supplementary Tables 2-5</xref>, <bold>bottom panel</bold>; total n<sub>cases</sub>=6,848; n<sub>controls</sub>=7,023). Four studies recruited participants from specialized clinics or hospitals based on absolute or percentile-derived cutoffs, and one study utilized liability-based (women) and standard-based (men) percentile cut-points. We performed a meta-analysis of these five studies and observed directionally consistent associations for all BMI-associated SNPs (<xref rid="SD2" ref-type="supplementary-material">Supplementary Table 10</xref>). The effect sizes in these extreme obesity studies were similar to those observed for tails of BMI in our analysis (<italic>P</italic><sub>heterogeneity</sub>>0.007 for all SNPs, Bonferroni-corrected). Four out of seven novel obesity-related loci displayed significance at <italic>P</italic><0.007 (Bonferroni-corrected) in these extremely obese studies.</p></sec><sec id="S8" sec-type="methods"><title>Effect of loci previously identified in extremely obese samples in our study</title><p id="P16">Previous studies of extreme childhood and/or adult obesity using different ascertainment strategies have reported genome-wide significant or near genome-wide significant associations (<italic>P</italic><5×10<sup>-7</sup>) with <italic>FTO, MC4R, TMEM18, FAIM2, TNKS, HOXB5, OLFM4, NPC1, MAF, PTER, SDCCAG8, PCSK1</italic> (rs6235 and rs6232) and <italic>KCNMA1</italic>.<sup><xref rid="R14" ref-type="bibr">14</xref>-<xref rid="R16" ref-type="bibr">16</xref>,<xref rid="R22" ref-type="bibr">22</xref>-<xref rid="R26" ref-type="bibr">26</xref></sup> With the exception of <italic>PCSK1</italic> (rs6232) for tails of BMI and <italic>MAF</italic> for tails of BMI and obesity class II, all associations showed consistent directions of effect across the BMI-related outcomes (<xref rid="SD2" ref-type="supplementary-material">Supplementary Table 11</xref>). Of the 13 loci, replication at a significance level of <italic>P</italic><0.004 (Bonferroni-corrected) was observed for four SNPs (<italic>FTO, MC4R, TMEM18, FAIM2</italic>) for the tails of BMI and all clinical classes of obesity Two loci, <italic>MAF</italic> and <italic>KCNMA1</italic>, which have thus far only been reported for extreme obesity, were not significantly associated with any of our traits at either a Bonferroni-corrected or nominal significance threshold (<italic>P</italic><0.05).</p></sec></sec><sec id="S9"><title>Empirical power comparison of the extremes and full distribution</title><p id="P17">If the extremes have different genetic inheritance or are etiologically more homogenous than the full distribution, analyzing extremes or tails of the distribution by case-control design may offer superior power. To test this empirically, we conducted meta-analyses of the full distributions of BMI and height with all studies included in stage 1 and stage 2. Only two (<italic>IGFBP4</italic> and <italic>H6PD</italic>) out of four novel loci for tails of height reached genome-wide significance (<italic>P</italic><5×10<sup>-8</sup>) using the full height distribution (<xref rid="T2" ref-type="table">Table 2</xref>). Four (<italic>GNAT2, ZZZ3, HNF4G</italic>, and <italic>RPTOR</italic>) out of seven novel loci identified for clinical classes of obesity achieved genome-wide significance for the full BMI distribution. The remaining loci had <italic>P</italic>-values <5×10<sup>-5</sup> in the full distribution and thus, would likely have been detected with a larger sample size.</p></sec><sec id="S10"><title>Systematic comparisons of the genetic inheritance and distribution of SNPs between the tails and full distribution</title><p id="P18">To investigate differences in genetic architecture between the tails and full distributions, we estimated whether the observed genetic effects in tails of BMI, height and WHR were different from what would be expected based on the full distributions of corresponding traits. To do this, we first estimated the expected effect for each SNP in the tails based on the full distribution in each study and then meta-analyzed the expected associations across studies. The Q-Q plots of <italic>P</italic>-values testing differences between the observed and expected (<xref rid="F1" ref-type="fig">Fig. 1</xref> and <xref rid="SD2" ref-type="supplementary-material">Supplementary Fig. 9</xref>) did not show any enrichment, indicating that effect sizes observed in tails and those expected based on the overall distribution were similar. Further, comparable results were observed for the 32 SNPs previously associated with BMI in Speliotes <italic>et al</italic><sup><xref rid="R4" ref-type="bibr">4</xref></sup>, as well as for previously published and novel extreme obesity loci (<xref rid="SD2" ref-type="supplementary-material">Supplementary Table 12</xref>).</p><p id="P19">To further compare genetic inheritance of the tails with the full distribution, we used a ‘polygene approach.’<sup><xref rid="R45" ref-type="bibr">45</xref></sup> The meta-analysis results of tails and full distribution were used to create two polygenetic scores (by summing the number of risk alleles at each SNP) in six studies (<xref rid="SD2" ref-type="supplementary-material">Supplementary Table 13</xref>). We found that the polygene score based on the full BMI distribution consistently explained more of the variance than the score based on the tails (e.g. 15.3% vs. 6.4% at <italic>P</italic><0.05) (<xref rid="F2" ref-type="fig">Fig. 2</xref>, <xref rid="SD2" ref-type="supplementary-material">Supplementary Table 14</xref>). Similar results were observed for height and WHR (<xref rid="SD2" ref-type="supplementary-material">Supplementary Fig. 10</xref>). On liability scale, the variance explained by the two polygene scores was similar for different BMI-related outcomes (<xref rid="SD2" ref-type="supplementary-material">Supplementary Fig. 11</xref>) and different percentile cutpoints used to define the tails (data not shown), suggesting that the fraction of the overall variance explained by SNPs is not influenced by the outcome categorization, but by the ability to accurately rank and estimate the beta coefficients of the association, which is better achieved by using the entire study population instead of the tails. Our results also indicate that genetic determinants for the tails are similar to those for the full distribution and that common variant loci contribute to extreme phenotypes. However, it should be noted that our analyses of the upper and lower 5 percentiles of the distribution (tails) does not necessarily extend to more extreme cut-offs, such as the top and bottom 1<sup>st</sup> percentiles.</p></sec><sec id="S11"><title>Allelic heterogeneity at known and discovered loci</title><p id="P20">To explore enrichment for allelic heterogeneity in the tails and clinical classes of obesity, we performed conditional analyses using a method recently described by Yang <italic>et al</italic>.<sup><xref rid="R46" ref-type="bibr">46</xref></sup> In these analyses, we found secondary signals that reached genome-wide significance (<italic>P</italic><5×10<sup>-8</sup>) at 17 loci, including one locus for tails of BMI (<italic>FTO</italic>), 13 loci for tails of height (<italic>PTCH1</italic> [two signals], <italic>GHSR, EDEM2, C6orf106, CRADD, EFEMP1, HHIP, FBXW11, NPR3, C2orf52, BCKDHB, EFR3B</italic>), one for tails of WHR (<italic>RSPO3</italic>), two for overweight (<italic>MC4R, FANCL</italic>), and one for obesity class I (<italic>FANCL</italic>; <xref rid="SD2" ref-type="supplementary-material">Supplementary Table 15</xref>). Whereas the secondary signals for tails of BMI (<italic>FTO</italic>) and WHR (<italic>RSPO3</italic>), and overweight and obesity class I (<italic>FANCL</italic>) have not been established previously, all 13 height loci identified here, as well as the <italic>MC4R</italic> locus have previously been shown to have allelic heterogeneity in the general population,<sup><xref rid="R7" ref-type="bibr">7</xref>,<xref rid="R9" ref-type="bibr">9</xref></sup> suggesting that there is no enrichment in the tails for secondary signals (<xref rid="SD2" ref-type="supplementary-material">Supplementary Fig. 12-14</xref>).</p><p id="P21">We also looked for evidence of enrichment of unobserved low-frequency variants by conducting haplotype analyses within known and novel loci, since haplotypes constructed from common SNPs may tag low-frequency variants that are enriched in the tails of the trait distributions, but are rarer in the general population. Using genotype data from the largest studies, three signals of association were observed for tails of height that exceeded conservative prior odds of association of one in 30,000: <italic>ID4</italic> (Bayes factor: 118,839), <italic>LIN28B</italic> (Bayes factor: 105,478) and <italic>DLEU7</italic> (Bayes factor: 66,599) (<xref rid="SD2" ref-type="supplementary-material">Supplementary Table 16</xref>). However, for all three loci, association signals were characterized by two clusters of haplotypes (both common and rare) and were not consistent with an enrichment of unobserved low-frequency causal variants in the distribution tails.</p></sec></sec><sec sec-type="discussion" id="S12"><title>Discussion</title><p id="P22">In our meta-analysis of genome-wide association studies of up to 263,407 individuals of European ancestry, we identified 165 loci associated with tails (upper vs. lower 5<sup>th</sup> percentile) of BMI, height, and WHR and/or clinical classes of obesity. Eleven of these loci have not previously been associated with anthropometric traits. Several of the novel loci were located near strong biological candidate genes, such as <italic>IGFBP4</italic> and <italic>SHOX2</italic> for tails of height, and <italic>HNF4G</italic> and <italic>ADCY9</italic> for overweight/obesity class I, suggesting future areas of research. Although by using different distribution cutoffs we discovered additional loci that would not have been identified as genome-wide significant using the full distribution of the same study samples, there is no evidence to suggest that the clinical classes of obesity are etiologically distinct, and the majority of evidence indicates that the extremes share many of the same loci with the general population.</p><p id="P23">To assess the impact of different distribution cutpoints on genetic variants associated with the extremes, we chose to evaluate the 5% tails of the distribution and clinical classes of obesity, specifically obesity classes II and III. Although others have ascertained extremes differently, all variants associated with obesity-related traits in our meta-analysis were found to have directionally consistent results in five independent studies of extremely obese samples. Of the 13 loci previously identified as associated with extreme obesity,<sup><xref rid="R14" ref-type="bibr">14</xref>-<xref rid="R16" ref-type="bibr">16</xref>,<xref rid="R22" ref-type="bibr">22</xref>-<xref rid="R26" ref-type="bibr">26</xref></sup> nearly all (except <italic>PCSK1</italic> rs6232 and <italic>MAF</italic>) showed a consistent direction of effect for the tails of BMI. Only two loci (<italic>MAF</italic> and <italic>KCNMA1</italic>), originally identified for early-onset and morbid adult obesity,<sup><xref rid="R14" ref-type="bibr">14</xref>,<xref rid="R26" ref-type="bibr">26</xref></sup> failed to replicate for any of our BMI-related outcomes. While it is possible that we had insufficient power if there was a substantial winner’s curse present in the initial publications, it is also conceivable that these susceptibility loci are population-specific, only contribute to risk at younger ages,<sup><xref rid="R47" ref-type="bibr">47</xref></sup> represent false positive findings, or tag rare causal variants that are difficult to detect in population-based samples.</p><p id="P24">Since our study was based on GWAS data, we were not well suited to address the role of rare variants in extreme traits. Although the haplotype-based analyses revealed strong associations of haplotypes in three genes with tails of height, which could suggest that they are tagged by rare variants, such putative variants could not be established using our approach. The suggestion that rare variants could be more important in extremes of complex traits needs to be addressed using other designs, such as resequencing projects or using the new Exome Chip microarrays that are currently being analyzed in many large study samples.</p><p id="P25">Our systematic comparisons between extremes and full distribution yielded several important insights that also may be informative for other complex traits. When comparing observed genetic effects in tails with expected effects extrapolated from overall distributions of corresponding traits, we did not observe any systematic differences. Further, we showed that the polygene score based on the full distribution explained a larger proportion of variance than the score based on the tails. Taken together with the finding that half of our novel loci were associated at genome-wide significant level in the overall distribution, this implies that there is limited etiologic heterogeneity in these anthropometric traits. Our analysis shows that while some common variants can have larger effects in the extremes, these effects as a whole are not larger than expected based on the effects in the overall distribution. Further, while rare variants specific to the extremes may still exist, the extremes share most of the common loci with the overall distribution.</p><p id="P26">Conclusions that can be drawn from these observations are that when having access to data for the full distribution, case-control analyses using extremes can be useful to find additional loci. Although the analyzing the full distribution is generally more powerful, small amounts of heterogeneity in the distribution may allow for the identification of additional loci by analyzing the data using different cut-points, such as the tails. Further, as in most cases when resources are limited, our results indicate that a strategy with selection of individuals from the extremes for genetic analyses could be a cost-effective approach and will likely yield loci that are relevant and largely generalizable to the full population. Compatible with those of recent, smaller studies,<sup><xref rid="R21" ref-type="bibr">21</xref>-<xref rid="R23" ref-type="bibr">23</xref></sup> our results show convincingly that this theoretically appealing approach also holds empirically.</p><p id="P27">In conclusion, in our large GWAS meta-analysis including up to 263,407 individuals, we identified four new loci influencing height detected at the tails, as well as seven new loci for clinical classes of obesity. Consistent with theoretical predictions and previous smaller studies, our results show that there is a large overlap in terms of genetic structure and distribution of variants between traits based on different distribution cutoffs with those from population-level studies, but additional insight may still be gained from evaluating the extremes. Our results are informative for designing future genetic studies of obesity as well as other complex traits.</p></sec><sec id="S13"><title>Online Methods</title><p id="P28">Detailed methods descriptions are available in the <xref rid="SD2" ref-type="supplementary-material">Supplementary Note</xref>.</p><sec id="S14"><title>Discovery and joint meta-analyses</title><sec id="S15"><title>Study design</title><p id="P29">We conducted a two-stage study for the tails of three anthropometric traits (BMI, WHR, and height) and four clinical classes of obesity (overweight and obesity classes I, II, and III), followed by a combined analysis of the two stages. Stage 1 consisted of a meta-analysis of GWAS utilizing data from a study base (or sampling frame) of up to 168,267 adult individuals of European ancestry from 51 studies participating in the Genetic Investigation of ANthropometric Traits (GIANT) consortium (<xref rid="SD2" ref-type="supplementary-material">Supplementary Tables 1-5</xref>). In stage 2, 273 SNPs with P-values < 5×10<sup>-6</sup> were followed up in up to 109,703 additional individuals of European descent, which included 67,243 individuals from 24 studies with data from the Metabochip (a custom-designed array of ~200,000 SNPs with prior evidence of suggestive association with metabolic traits), and 42,460 individuals from 12 studies with <italic>in silico</italic> replication GWAS data (<xref rid="SD2" ref-type="supplementary-material">Supplemental Tables 1-5</xref>). This gave us a study base of up to 276,007 individuals of European descent for the joint meta-analysis of stage 1 and stage 2. For full details about the discovery and replication stages, analysis of data, and meta-analyses, see <xref rid="SD2" ref-type="supplementary-material">Supplementary Note</xref>.</p></sec><sec id="S16"><title>Phenotype definitions</title><p id="P30">The tails of the three anthropometric traits (BMI, height, and WHR) were defined as the upper 5<sup>th</sup> percentile (cases) and lower 5<sup>th</sup> percentile (controls) of the distribution stratified by sex and disease status after controlling for the following covariates: age, age<sup>2</sup> and principal components for BMI; age and principal components for height; and age, age<sup>2</sup>, BMI and principal components for WHR. For the clinical obesity classes, cases were defined as BMI ≥25 kg/m<sup>2</sup> for overweight, BMI ≥30 kg/m<sup>2</sup> for obesity class I, BMI ≥35 kg/m<sup>2</sup> for obesity class II, and BMI ≥40 kg/m<sup>2</sup> for obesity class 3. Controls were subjects with BMI <25 kg/m<sup>2</sup>. A minimum of 30 cases and 30 controls for each study-specific stratum was required.</p></sec><sec id="S17"><title>Association analyses and meta-analyses</title><p id="P31">Each study conducted single marker association analyses assuming an additive genetic model taking genotype imputation uncertainty into account. Analyses were stratified by sex (except for studies with related individuals where analyses accounted for family structure) and disease status for studies that ascertained participants based on a relevant disease (e.g., diabetes). Before meta-analyzing data, results from each study were extensively reviewed using standardized quality control procedures to identify potential problems, such as strand issues, discrepancies between the reported standard errors and p-values, and allele frequency differences. SNPs with poor imputation quality scores or estimated minor allele count ≤ 20 (i.e. 2 × N × minor allele frequency) in each stratum (men/women or pooled for family-based studies) of each study were removed from analysis. For the discovery stage 1, each stratum- and study-specific GWAS was corrected for genomic control. Meta-analyses were performed for each phenotype in METAL<sup><xref rid="R48" ref-type="bibr">48</xref></sup> using the fixed effects inverse variance method based on the β estimates and standard errors from each study. The results of the discovery meta-analysis were followed by an additional genomic control correction. Similar methods were employed for the replication and joint discovery and replication analysis.</p></sec></sec><sec id="S18"><title>Association testing in extremely obese studies</title><p id="P32">We tested the association of all SNPs reaching <italic>P</italic><5×10<sup>-8</sup> in the joint analysis of stage 1 and stage 2 results for the BMI-related traits, in five studies of extremely obese individuals (<xref rid="SD2" ref-type="supplementary-material">Supplementary Tables 2-5</xref>). For the four case-control studies (French Extreme Obesity Study, Essen Case-Control GWAS, GEO and GOYA), a fixed effects inverse variance method was used to meta-analyze the results. A fifth study (Essen Obesity Trio GWAS) that has a nuclear family structure was meta-analyzed with the four case-control studies using a weighted z-score method that takes into account the direction but not the magnitude of the association.</p></sec><sec id="S19"><title>Systematic comparison of the genetic structure between tails and overall distribution</title><p id="P33">For these analyses, we included all GWAS studies that provided genome-wide results for both the full distribution and tails of BMI, height and WHR. First, we used the results for the full distribution to calculate, for each genotype, the expected number of individuals in the upper and lower 5% tails. We used these values to perform a logistic regression, comparing the upper and lower tails, and obtained the ‘expected beta’ and ‘expected standard error’. Second, we tested the differences between the ‘expected betas’ and the ‘observed betas’ obtained from the meta-analyses of the tails of the distributions. The standard error of the differences was estimated as: sqrt[expected standard error ˆ2 + observed standard error ˆ2 - 2*0.65*(expected standard error* observed standard error)], where 0.65 is the correlation between ‘expected betas’ and ‘observed betas’ obtained from TWINGENE by bootstrapping. Finally, differences between ‘expected betas’ and ‘observed betas’ were meta-analyzed using the inverse variance method in METAL.</p></sec><sec id="S20"><title>Polygene comparison of genetic determinants of the BMI tails and overall distribution</title><p id="P34">Within each trait (BMI, height and WHR), we aimed to compare variance explained in tails of the trait by two genetic scores (polygene scores) obtained from (1) the meta-analyses of the tails of the trait and (2) the meta-analyses of the full distribution. To make the scores comparable, we limited the polygene score construction to the studies that provided genome-wide meta-analysis results for both tails and overall distribution. After LD filtering (using r<sup>2</sup>≥0.05 and 1 Mb distance) and excluding SNPs present in <50% of samples, we created polygene scores, as weighted sum of risk alleles, using the method proposed by the International Schizophrenia Consortium.<sup><xref rid="R45" ref-type="bibr">45</xref></sup> For the BMI analysis, the association between the polygene scores and tails of BMI was investigated in four samples of extremely obese and two independent cohort studies using the same definition of tails (<xref rid="SD2" ref-type="supplementary-material">Supplementary Table 13</xref>). Only the two independent cohorts were used for the height and WHR analysis. To estimate the phenotypic variance explained, we fit logistic or linear regression models including age, sex, study-specific covariates and the polygene score as predictors, and tails of the trait or overall trait as outcomes, in separate models. The phenotypic variance explained by the polygene scores was defined as the difference in R<sup>2</sup> (linear regression) or Nagelkerke R<sup>2</sup> (logistic regression) between these models and a basic model including only age, sex and study-specific covariates as predictors.</p></sec><sec id="S21"><title>Secondary signals analysis</title><p id="P35">To identify potential secondary signals, we utilized the approximate conditional and joint analysis proposed by Yang et al,<sup><xref rid="R46" ref-type="bibr">46</xref></sup> which uses summary-level statistics and the LD structure from a reference sample to approximate conditional p-values. The meta-analysis results for each trait were analyzed separately with LD correction between SNPs estimated from 6,654 unrelated individuals from the ARIC cohort.</p></sec><sec id="S22"><title>Haplotype-based analyses</title><p id="P36">Using data from ten of the largest studies, we tested the association between the tails of height, BMI and WHR and haplotypes across each established and novel locus separately for males and females within each study, using GENEBPM.<sup><xref rid="R49" ref-type="bibr">49</xref></sup> The haplotypes were estimated from GWAS SNP data by means of an expectation-maximization algorithm and then clustered according to their allelic similarity. Within a logistic regression-modelling framework, haplotypes within the same cluster were assigned the same allelic effect, reducing the required number of parameters. Markov-chain Monte Carlo techniques were employed to sample over the space of haplotype clusters and regression model parameters. Evidence in favour of a haplotype association with the trait was assessed by summing log<sub>10</sub> Bayes factors across studies.</p></sec><sec id="S23"><title>eQTL analyses</title><p id="P37">We examined the <italic>cis</italic> associations between SNPs that reached genome-wide significance (P < 5 × 10<sup>-8</sup>) and expression of nearby genes in multiple tissues from 5 studies described previously: 1) subcutaneous adipose tissue (n=603) and whole blood (n=747) from deCode<sup><xref rid="R50" ref-type="bibr">50</xref></sup>; 2) lymphoblastoid cell lines (n=830) from a childhood asthma study<sup><xref rid="R51" ref-type="bibr">51</xref></sup>; 3) liver (n=707), subcutaneous fat (n=870) and omental fat (n=916) tissue from a bariatric surgery study<sup><xref rid="R52" ref-type="bibr">52</xref></sup>; 4) subcutaneous abdominal (N=52) and gluteal (N=62) adipose tissue and whole blood (n=65) from MolOBB<sup><xref rid="R53" ref-type="bibr">53</xref></sup>; and 5) cortical brain tissue (n=193) survey study.<sup><xref rid="R54" ref-type="bibr">54</xref></sup> SNPs were tested for <italic>cis</italic> associations with transcripts within 500 kb or 1 Mb, assuming an additive effect of the BMI allele or using an ANOVA test with study-specific p-value thresholds used to account for multiple testing. Conditional analyses were performed for all expression data, except for cortical tissue, by conditioning the trait-associated SNP on the most significant <italic>cis</italic>-associated SNP for that particular gene transcript and vice versa.</p></sec></sec><sec sec-type="supplementary-material" id="S24"><title>Supplementary Material</title><supplementary-material content-type="local-data" id="SD2"><label>1</label><media xlink:href="NIHMS536922-supplement-1.pdf" orientation="portrait" xlink:type="simple" id="d37e4964" position="anchor"></media></supplementary-material></sec></body><back><ack id="S25"><p>A full list of acknowledgments appears in the <xref rid="SD2" ref-type="supplementary-material">Supplementary Note</xref>.</p><p>Aarno Koskelo Foundation; Academy of Finland; Agency for Science, Technology and Research of Singapore; Australian National Health and Medical Research Council; Australian Research Council; BDA Research; BioSHaRE Consortium; British Heart Foundation; Cedars-Sinai Board of Governors’ Chair in Medical Genetics; Centre for Clinical Research at the University of Leipzig; Centre of Excellence in Genomics and University of Tartu; Chief Scientist Office of the Scottish Government; City of Kuopio and Social Insurance Institution of Finland; Department of Educational Assistance, University and Research of the Autonomous Province of Bolzano; Donald W. Reynolds Foundation; Dutch Ministry for Health, Welfare and Sports; Dutch Ministry of Education, Culture and Science; Dutch BBRMI-NL; Dutch Brain Foundation; Dutch Centre for Medical Systems Biology; Dutch Diabetes Research Foundation; Dutch Government Economic Structure Enhancing Fund; Dutch Inter University Cardiology Institute; Dutch Kidney Foundation; Dutch Ministry of Economic Affairs; Dutch Ministry of Justice; Dutch Research Institute for Diseases in the Elderly; Eleanor Nichols endowments; Emil Aaltonen Foundation; Erasmus Medical Center and Erasmus University; Estonian Government; European Commission; European Regional Development Fund; European Research Council; European Science Foundation; Faculty of Biology and Medicine of Lausanne; Finland’s Slot Machine Association; Finnish Cultural Foundation; Finnish Diabetes Research Foundation; Finnish Foundation for Cardiovascular Research; Finnish Funding Agency for Technology and Innovation; Finnish Heart Association; Finnish Medical Society; Finnish Ministry of Education and Culture; Finnish Ministry of Health and Social Affairs; Finnish National Institute for Health and Welfare; Finnish Social Insurance Institution; Finska Läkaresällskapet; Folkhälsan Research Foundation; Foundation for Life and Health in Finland; French Ministry of Research; French National Research Agency; Genetic Association Information Network; German Diabetes Association; German Federal Ministry of Education and Research; German Ministry of Cultural Affairs; German National Genome Research Network; German Research Foundation; GlaxoSmithKline; Göteborg Medical Society; Greek General Secretary of Research and Technology; Gyllenberg Foundation; Health Care Centers in Vasa, Närpes and Korsholm; Heinz Nixdorf Foundation; Helmholtz Zentrum München, German Research Center for Environmental Health; Icelandic Heart Association; Icelandic Parliament; Intramural Research Program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH; Italian Ministry of Education, Universities and Research; Italian Ministry of Health; Juho Vainio Foundation; Juvenile Diabetes Research Foundation International; Knut and Alice Wallenberg Foundation; Kuopio, Tampere and Turku University Hospital Medical Funds; Leducq Foundation; Lundberg Foundation; March of Dimes; Munich Center of Health Sciences as part of LMUinnovativ; Municipal Health Care Center and Hospital in Jakobstad; Municipality of Rotterdam; Närpes Health Care Foundation; National Alliance for Research on Schizophrenia and Depression Young Investigator Awards; Netherlands Genomics Initiative; Netherlands organization for health research and development; NHSBT; National Institute of Health; Nordic Center of Cardiovascular Research; Nordic Center of Excellence in Disease Genetics; Nordic Centre of Excellence on Systems biology in controlled dietary interventions and cohort studies; Northern Netherlands Collaboration of Provinces; Novo Nordisk Foundation; Ollqvist Foundation; Orion-Farmos Research Foundation; Paavo Nurmi Foundation; Päivikki and Sakari Sohlberg Foundation; Perklén Foundation; Petrus and Augusta Hedlunds Foundation; Province of Groningen; Republic of Croatia Ministry of Science, Education and Sport; Reynold’s Foundation; Royal Society; Samfundet Folkhälsan; Signe and Ane Gyllenberg foundation; Sigrid Juselius Foundation; Social Ministry of the Federal State of Mecklenburg-West Pomerania; Sophia Foundation for Medical Research; South Tyrolean Sparkasse Foundation; Southern California Diabetes Endocrinology Research Center; Stockholm County Council; Strategic Cardiovascular Program of Karolinska Institutet; Strategic support for epidemiological research at Karolinska Institutet; Susan G. Komen Breast Cancer Foundation; Swedish Ministry for Higher Education; Swedish Cancer Society; Swedish Cultural Foundation in Finland; Swedish Diabetes Association; Swedish Foundation for Strategic Research; Swedish Heart-Lung Foundation; Swedish Medical Research Council; Swedish Ministry of Education; Swedish Research Council; Swedish Royal Academy of Science; Swedish Society for Medical Research; Swedish Society of Medicine; Swiss National Science Foundation; Tampere Tuberculosis Foundation; The Great Wine Estates of the Margaret River region of Western Australia; The Paul Michael Donovan Charitable Foundation; Torsten and Ragnar Söderberg Foundation; UK Cancer Research; UK Diabetes Association; UK Heart Foundation; UK Medical Research Council; UK National Institute for Health Research, Biomedical Research Centre; UK West Anglia Primary and Community Care; University Medical Center Groningen and University of Groningen; Västra Götaland Foundation; VU University: Institute for Health and Care Research and Neuroscience Campus Amsterdam; Wellcome Trust; Yrjö Jahnsson Foundation.</p></ack><fn-group><fn id="FN3" fn-type="conflict"><p><bold><underline>Competing interest statements</underline></bold></p><p>Kari Stefansson, Valgerdur Steinthorsdottir, Gudmar Thorleifsson and Unnur Thorsteinsdottir are employed by deCODE Genetics with stock/stock options in the company. Inês Barroso and spouse own stock in Incyte Ltd and GlaxoSmithKline. Eric E. Schadt is Chief Scientific Officier, Pacific Biosciences. Thorkild IA Sørensen has collaborated with Nestlé Research Centre and DSM, The Netherlands, on metabolomics and genomics of obesity and related traits, respectively.</p></fn></fn-group><app-group><app id="APP1"><title>Appendix</title><sec id="S26" sec-type="appendix"><title>Author contributions</title><p id="P39"><bold><underline>Steering committee (oversaw the consortium)</underline></bold></p><p id="P40">Goncalo R Abecasis, Themistocles Assimes, Ines Barroso, Sonja Berndt, Michael Boehnke, Ingrid Borecki, Panos Deloukas, Caroline Fox, Tim Frayling, Leif Groop, Talin Haritunian, Iris Heid, David Hunter, Erik Ingelsson, Robert C Kaplan, Ruth JF Loos, Mark McCarthy, Karen Mohlke, Kari E North, Jeffrey R O’Connell, David Schlessinger, David Strachan, Unnur Thorsteinsdottir, Cornelia van Duijn</p><p id="P41"><bold><underline>Writing group (drafted and edited manuscript)</underline></bold></p><p id="P42">Sonja I Berndt, Mary F Feitosa, Andrea Ganna, Stefan Gustafsson, Erik Ingelsson, Anne E Justice, Cecilia M Lindgren, Ruth JF Loos, Reedik Mägi, Mark McCarthy, David Meyre, Keri L Monda, Andrew P Morris, Kari E North, André Scherag, Elizabeth K Speliotes, Eleanor Wheeler, Cristen J Willer</p><p id="P43"><bold><underline>Data cleaning and preparation</underline></bold></p><p id="P44">Sonja I Berndt, Damien C Croteau-Chonka, Felix R Day, Tõnu Esko, Tove Fall, Teresa Ferreira, Stefan Gustafsson, Iris Heid, Erik Ingelsson, Anne U Jackson, Hana Lango Allen, Cecilia M Lindgren, Jian’an Luan, Reedik Mägi, Joshua C Randall, André Scherag, Elizabeth K Speliotes, Gudmar Thorleifsson, Sailaja Vedantam, Thomas W Winkler, Andrew R Wood</p><p id="P45"><bold><underline>Statistical Advisors</underline></bold></p><p id="P46">Sang Hong Lee, Benjamin M Neale, Yudi Pawitan, Peter M Visscher, Jian Yang, Dan-Yu Lin, Yi-Juan Hu</p><p id="P47"><bold><underline>Gene-expression (eQTL) analyses</underline></bold></p><p id="P48">Liming Liang, William O Cookson, Miriam F Moffatt, Goncalo R Abecasis, Valgerdur Steinthorsdottir, Gudmar Thorleifsson, Josine L Min, George Nicholson, Fredrik Karpe, Mark I McCarthy, Eric E Schadt</p><p id="P49"><bold><underline>Project design, management and coordination of contributing studies</underline></bold></p><p id="P50"><bold><italic>Stage 1 – Genome-wide association studies</italic></bold></p><p id="P51">(ADVANCE) Themistocles L Assimes, Carlos Iribarren; (AGES) Vilmundur Gudnason, Tamara B Harris, Lenore J Launer; (ARIC) Eric Boerwinkle, Kari E North; (B58C) David P Strachan; (BRIGHT study) Mark J Caulfield, Patricia B Munroe; (CAPS) Erik Ingelsson; (CHS) Barbara McKnight, Bruce M Psaty; (CoLaus) Vincent Mooser, Peter Vollenweider, Gérard Waeber; (COROGENE) Markku S Nieminen, Juha Sinisalo; (deCODE) Kari Stefansson, Unnur Thorsteinsdottir; (DGI) Leif C Groop, Joel N Hirschhorn; (EGCUT) Andres Metspalu; (EPIC) Kay-Tee Khaw, Ruth JF Loos, Nicholas J Wareham; (ERF) Ben A Oostra, Cornelia M van Duijn; (FamHS) Ingrid B Borecki, Michael A Province; (Fenland) Ruth JF Loos, Nicholas J Wareham; (FRAM) L A Cupples, Caroline S Fox; (FUSION GWAS) Michael Boehnke, Karen L Mohlke; (Genmets) Antti Jula, Samuli Ripatti, Veikko Salomaa; (GerMIFS1) Jeanette Erdmann, Heribert Schunkert; (GerMIFS2) Christian Hengstenberg, Klaus Stark; (GOOD) Claes Ohlsson; (HBCS) Johan G Eriksson; (KORA S3) H.- E Wichmann; (KORA S4) Christian Gieger, Thomas Illig, Wolfgang Koenig, Annette Peters; (MGS) Pablo V Gejman, Douglas F Levinson; (MICROS (SOUTH TYROL)) Peter P Pramstaller; (MIGEN) Joel N Hirschhorn, Sekar Kathiresan; (NESDA) Brenda Penninx; (NFBC 1966) Marjo-Riitta Jarvelin; (NHS) Lu Qi; (Nijmegen Biomedical Study) Lambertus A Kiemeney; (NSPHS) Ulf Gyllensten; (NTR) Dorret I Boomsma; (ORCADES) James F Wilson, Alan F Wright; (PLCO) Stephen J Chanock, Sonja I Berndt; (PROCARDIS) Martin Farrall, Hugh Watkins; (RS-I) Fernando Rivadeneira, André G Uitterlinden; (RUNMC) Lambertus A. Kiemeney; (SardiNIA) David Schlessinger; (SASBAC) Erik Ingelsson; (SHIP) Henri Wallaschofski; (Sorbs) Michael Stumvoll, Anke Tönjes; (TwinsUK) Tim D Spector; (VIS) Igor Rudan; (WGHS) Paul M Ridker; (WTCC-T2D) Mark I McCarthy; (WTCCC-CAD) Anthony J Balmforth, Alistair S Hall, Nilesh J Samani; (YFS) Mika Kähönen, Terho Lehtimäki, Olli Raitakari, Jorma Viikari</p><p id="P52"><bold><italic>Stage 2 – Metabochip/in silico replication</italic></bold></p><p id="P53">(AMC-PAS) Kees G Hovingh; (B58C) Chris Power; (BHS) Lyle J Palmer; (DILGOM) Kari Kuulasmaa, Veikko Salomaa; (DPS) Matti Uusitupa; (DR’s EXTRA) Timo A Lakka, Rainer Rauramaa; (EPIC, Fenland and Ely) Claudia Langenberg, Ruth JF Loos, Nicholas J Wareham; (FIN-D2D 2007) Sirkka M Keinanen-Kiukaanniemi, Timo E Saaristo; (GLACIER) Paul W Franks; (Go-DARTS (Dundee)) Andrew D Morris, Colin NA Palmer; (HNR) Karl-Heinz Jöckel; (HUNT 2) Kristian Hveem; (Hypergenes) Daniele Cusi; (IMPROVE) Ulf de Faire, Anders Hamsten, Elena Tremoli; (KORA S3) Iris Heid; (LifeLines Cohort Study) Harold Snieder, Melanie M Van der Klauw, Bruce HR Wolffenbuttel; (LURIC) Bernhard O Boehm, Winfried März, Bernhard R Winkelmann; (METSIM) Johanna Kuusisto, Markku Laakso; (MORGAM) Philippe Amouyel, Paolo Brambilla, Marco M Ferrario, Jean Ferrières, Frank Kee, David-Alexandre Tregouet, Jarmo Virtamo; (NSHD) Diana Kuh; (PIVUS) Erik Ingelsson; (PLCO2) Sonja I Berndt, Stephen J Chanock; (PREVEND) Pim van der Harst; (QIMR) Nicholas G Martin, Grant W Montgomery, Andrew Heath, Pamela Madden; (RS-II) Albert Hofman, Joyce BJ van Meurs; (RS-III) Cornelia M Van Duijn, Jacqueline CM Witteman; (Swedish Twin Reg.) Erik Ingelsson; (THISEAS / AMCPAS / CARDIOGENICS) Panos Deloukas; (THISEAS) George V Dedoussis; (TRAILS) Albertine J Oldehinkel; (Tromsø 4) Inger Njølstad; (TWINGENE) Erik Ingelsson; (ULSAM) Erik Ingelsson; (Whitehall II) Aroon Hingorani, Mika Kivimäki; (WTCC-T2D) Mark I McCarthy, Cecilia M Lindgren</p><p id="P54"><bold><italic>Other contributing studies: clinically extremes</italic></bold></p><p id="P55">(French Extreme Obesity Study) David Meyre, Philippe Froguel; (GEO-IT) Anna Maria Di Blasio; (Essen Obesity Study, Essen Case-Control & Essen Obesity Trio GWAS) Johannes Hebebrand, Anke Hinney; (GOYA) Thorkild IA Sørensen, Ellen A Nohr</p><p id="P56"><bold><underline>Genotyping of contributing studies</underline></bold></p><p id="P57"><bold><italic>Stage 1 – Genome-wide association studies</italic></bold></p><p id="P58">(ADVANCE) Devin Absher; (ARIC) Eric Boerwinkle; (B58C) Wendy L McArdle; (CAPS) Henrik Grönberg; (CHS) Talin Haritunians; (CoLaus) Vincent Mooser; (COROGENE) Markus Perola; (EGCUT) Tõnu Esko, Lili Milani; (EPIC) Inês Barroso; (ERF) Ben A Oostra, Cornelia M van Duijn; (FamHS) Ingrid B Borecki, Michael A Province, Aldi T Kraja; (Fenland) Jian’an Luan; (Genmets) Samuli Ripatti; (GOOD) Claes Ohlsson, John-Olov Jansson, Mattias Lorentzon; (HBCS) Aarno Palotie, Elisabeh Widén; (MGS) Pablo V Gejman, Alan R Sanders; (MICROS (SOUTH TYROL)) Andrew A Hicks; (NHS) Frank B Hu, David Hunter; (NSPHS) Åsa Johansson; (NTR and NESDA) Jouke- Jan Hottenga; (ORCADES) James F Wilson; (PLCO) Stephen J Chanock, Kevin B Jacobs; (RS-I) Fernando Rivadeneira, André G Uitterlinden, Karol Estrada, Carolina Medina-Gomez; (SardiNIA) Mariano Dei; (SASBAC) Per Hall, Jianjun Liu; (SHIP) Georg Homuth; (TwinsUK) Massimo Mangino, So-Youn Shin, Nicole Soranzo; (VIS) Caroline Hayward, Veronique Vitart; (WGHS) Daniel I Chasman; (WTCC-T2D) Mark I McCarthy; (WTCCC-CAD) Anthony J Balmforth, Alistair S Hall, Nilesh J Samani; (YFS) Terho Lehtimäki</p><p id="P59"><bold><italic>Stage 2 – Metabochip/in silico replication</italic></bold></p><p id="P60">(BHS) Lyle J Palmer, John Beilby; (CARDIOGENICS) Sarah Edkins, Sarah E Hunt; (DPS) Amy J Swift; (DR’s EXTRA) Mustafa Atalay; (EPIC, Fenland and Ely) Jian’an Luan, Ken K Ong; (FIN-D2D 2007) Peter S Chines; (FUSION) Francis S Collins, Jouko Saramies, Jaakko Tuomilehto; (GLACIER) Inês Barroso, Sarah Edkins; (Go-DARTS (Dundee)) Colin NA Palmer; (HNR) Thomas W Mühleisen; (HUNT 2) Narisu Narisu; (Hypergenes) Francesca Frau; (KORA S3) Harald Grallert; (KORA S4) Thomas Illig; (LifeLines Cohort Study) Harold Snieder, Bruce HR Wolffenbuttel, Marcel Bruinenberg. Lude Franke; (NSHD) Diana Kuh, Ken K Ong, Andrew Wong; (PIVUS) Erik Ingelsson, Lars Lind; (PLCO2) Stephen J Chanock, Kevin B Jacobs, Zhaoming Wang; (PREVEND) Pim van der Harst, Folkert W Asselbergs; (QIMR) Nicholas G Martin, Grant W Montgomery, Andrew C Heath, Pamela A Madden; (RS-II) Marjolein Peters, Mariano Dei; (Swedish Twin Reg.) Erik Ingelsson, Patrik K Magnusson, Nancy Pedersen; (THISEAS / AMCPAS / CARDIOGENICS) Kathleen Stirrups; (TRAILS) Albertine J Oldehinkel, Ilja M Nolte, Jana V Van Vliet-Ostaptchouk; (Tromsø 4) Lori L Bonnycastle; (TWINGENE) Erik Ingelsson, Anders Hamsten, Nancy Pedersen; (ULSAM) Erik Ingelsson; (Whitehall II) Claudia Langenberg; (WTCC-T2D) Mark I McCarthy</p><p id="P61"><bold><italic>Other contributing studies: clinically extremes</italic></bold></p><p id="P62">(French Extreme Obesity Study) David Meyre, Philippe Froguel; (GEO-IT) Davide Gentilini; (GOYA) Lavinia Paternoster, David M Evans</p><p id="P63"><bold><underline>Phenotyping of contributing studies</underline></bold></p><p id="P64"><bold><italic>Stage 1 – Genome-wide association studies</italic></bold></p><p id="P65">(ARIC) Eric Boerwinkle; (B58C) David P Strachan; (BRIGHT study) John M Connell; (CAPS) Henrik Grönberg; (CHS) Bruce M Psaty; (CoLaus) Peter Vollenweider, Gérard Waeber; (COROGENE) Juha Sinisalo, Marja-Liisa Lokki; (EGCUT) Andres Metspalu, Krista Fischer; (EPIC) Ruth JF Loos; (ERF) Ben A Oostra, Cornelia M van Duijn; (FamHS) Ingrid B Borecki, Michael A Province, Mary F Feitosa; (Fenland) Ruth JF Loos; (FRAM) Caroline S Fox; (Genmets) Antti Jula, Veikko Salomaa; (GerMIFS1) Stefan Schreiber; (GerMIFS2) Annette Peters; (GOOD) Claes Ohlsson, John-Olov Jansson, Mattias Lorentzon, Liesbeth Vandenput; (MGS) Pablo V Gejman, Alan R Sanders, Douglas F Levinson; (NFBC 1966) Anna-Liisa Hartikainen, Jaana H Laitinen, Anneli Pouta; (NHS) Lu Qi; (Nijmegen Biomedical Study) Femmie de Vegt, Martin den Heijer, Sita H Vermeulen; (NSPHS) Åsa Johansson, Ulf Gyllensten; (NTR and NESDA) Gonneke Willemsen; (ORCADES) Harry Campbell, Sarah H Wild; (PLCO) Sonja I Berndt; (RS-I) Fernando Rivadeneira, André G Uitterlinden; (SASBAC) Per Hall; (SHIP) Sabine Schipf; (Sorbs) Anke Tönjes; (TwinsUK) Massimo Mangino, Tim D Spector; (VIS) Ozren Polasek; (WTCC-T2D) Mark I McCarthy; (WTCCC-CAD) Anthony J Balmforth, Alistair S Hall, Nilesh J Samani; (YFS) Mika Kähönen, Olli Raitakari, Jorma Viikari</p><p id="P66"><bold><italic>Stage 2 – Metabochip/in silico replication</italic></bold></p><p id="P67">(AMC-PAS) Hanneke Basart, Mieke D Trip; (B58C) Chris Power, Elina Hyppönen; (BHS) Lyle J Palmer, John Beilby, Arthur W Musk; (DPS) Jaana Lindström; (EPIC, Fenland and Ely) Ruth JF Loos; (GLACIER) Paul W Franks, Dmitry Shungin; (Go-DARTS (Dundee)) Colin NA Palmer, Andrew D Morris; (Hypergenes) Daniele Cusi, Paolo Manunta; (KORA S3) Barbara Thorand; (KORA S4) Annette Peters; (LifeLines Cohort Study) Bruce HR Wolffenbuttel, Melanie M Van der Klauw; (METSIM) Alena Stančáková, Pablo V Gejman; (NSHD) Diana Kuh; (PIVUS) Erik Ingelsson, Lars Lind; (PLCO2) Sonja I Berndt; (PREVEND) Gerjan Navis; (QIMR) Nicholas G Martin, Andrew Heath, Pamela Madden; (RS-II) M Carola Zillikens; (RS-III) Jacqueline CM Witteman; (Swedish Twin Reg.) Erik Ingelsson, Patrik K Magnusson, Nancy Pedersen; (THISEAS) Maria Dimitriou, Eirini V Theodoraki; (TRAILS) Ronald P Stolk; (TWINGENE) Erik Ingelsson, Nancy Pedersen; (ULSAM) Erik Ingelsson; (Whitehall II) Meena Kumari; (WTCC-T2D) Mark I McCarthy</p><p id="P68"><bold><italic>Other contributing studies: clinically extremes</italic></bold></p><p id="P69">(Essen Obesity Study, Essen Case-Control GWAS & Essen Obesity Trio GWAS) Johannes Hebebrand, Anke Hinney; (GEO-IT) Antonio Liuzzi, Stefano Signorini; (GOYA) Thorkild IA Sørensen, Ellen A Nohr</p><p id="P70"><bold><underline>Analyses of contributing studies</underline></bold></p><p id="P71"><bold><italic>Stage 1 – Genome-wide association studies</italic></bold></p><p id="P72">(ADVANCE) Lindsay L Waite; (AGES) Albert V Smith; (ARIC) Kari E North, Anne E Justice, Keri L Monda; (B58C) David P Strachan; (BRIGHT study) Toby Johnson; (CAPS) Erik Ingelsson, Reedik Mägi; (CHS) Barbara McKnight, Guo Li; (CoLaus) Diana Marek; (COROGENE) Markus Perola; (deCODE) Valgerdur Steinthorsdottir, Gudmar Thorleifsson; (DGI) Elizabeth K Speliotes, Sailaja Vedantam; (EGCUT) Krista Fischer, Tõnu Esko, Evelin Mihailov; (EPIC) Jing Hua Zhao; (ERF) Najaf Amin; (FamHS) Mary F Feitosa; (Fenland) Jian’an Luan; (FRAM) L A Cupples, Nancy L Heard-Costa, Julius S Ngwa; (Genmets) Ida Surakka; (GerMIFS1) Michael Preuss; (GerMIFS2) Inke R König; (GOOD) Claes Ohlsson, John-Olov Jansson, Mattias Lorentzon, Liesbeth Vandenput; (HBCS) Niina Eklund; (KORA S3) Claudia Lamina; (KORA S4) Eva Albrecht; (MGS) Douglas F Levinson, Jianxin Shi; (MICROS (SOUTH TYROL)) Jennifer E Huffman, Åsa Johansson; (MIGEN) Elizabeth K Speliotes, Sailaja Vedantam; (NFBC 1966) Anneli Pouta, Reedik Magi, Joshua C Randall; (NHS) Lu Qi, Tsegaselassie Workalemahu; (NSPHS) Åsa Johansson; (NTR and NESDA) Jouke- Jan Hottenga, Marleen H. de Moor; (ORCADES) Åsa Johansson; (PLCO) Kevin B Jacobs, Sonja I Berndt; (PROCARDIS) Martin Farrall, Anuj Goel, John F Peden; (RS-I) Fernando Rivadeneira, Karol Estrada, Carolina Medina-Gomez; (SardiNIA) Jennifer L Bragg-Gresham, Serena Sanna; (SASBAC) Erik Ingelsson, Reedik Mägi; (SEARCH) Jonathan Tyrer; (SHIP) Alexander Teumer; (Sorbs) Reedik Mägi, Inga Prokopenko; (TwinsUK) Massimo Mangino, Nicole Soranzo; (VIS) Åsa Johansson; (WGHS) Daniel I Chasman; (WTCC-T2D) Cecilia M Lindgren, Reedik Magi, Joshua C Randall; (WTCCC-CAD) Reedik Magi, Joshua C Randall; (WTCCC-NBS (UKBS-CC)) Antony P Attwood, Reedik Magi, Joshua C Randall, Jennifer G Sambrook, Jonathan C Stephens; (YFS) Olli Raitakari, Terho Lehtimäki</p><p id="P73"><bold><italic>Stage 2 – Metabochip/in silico replication</italic></bold></p><p id="P74">(B58C) Elina Hyppönen, Teresa Ferreira; (BHS) Gemma Cadby; (DILGOM) Kati Kristiansson; (DPS) Anne U Jackson; (DR’s EXTRA) Anne U Jackson; (EPIC, Fenland and Ely) Jian’an Luan, Ken K Ong; (FIN-D2D 2007) Anne U Jackson; (FUSION) Anne U Jackson; (GLACIER) Paul W Franks, Dmitry Shungin; (HNR) Sonali Pechlivanis, Carolin Pütter; (HUNT 2) Anne U Jackson; (Hypergenes) Francesca Frau, Zoltán Kutalik; (IMPROVE) Rona J Strawbridge; (KORA S3) Iris Heid, Thomas W Winkler; (KORA S4) Martina Müller-Nurasyid; (LifeLines Cohort Study) Marcel Bruinenberg, Lude Franke; (LURIC) Marcus E Kleber; (METSIM) Anne U Jackson; (NSHD) Andrew Wong, Jian’an Luan; (PIVUS) Erik Ingelsson, Stefan Gustafsson; (PLCO2) Sonja I Berndt, Zhaoming Wang; (PREVEND) Pim van der Harst, Irene Mateo Leach; (QIMR) Sarah E Medland, Jian Yang; (RS-II) Marjolein Peters; (Swedish Twin Reg.) 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The <italic>y-axis</italic> represents the proportion of variance explained (Nagelkerke R<sup>2</sup>) of extreme obesity in six studies not included in the discovery meta-analysis. In panel A, the prediction model was based on the results from the stage I meta-analysis of tails of BMI. The thicker lines represent the weighted average; 95% confidence intervals are reported as double-headed arrows. In panel B, the prediction model was based on BMI from the full distribution (modified version of the previous GIANT meta-analysis by Speliotes <italic>et al</italic><sup><xref rid="R4" ref-type="bibr">4</xref></sup>). * Essen Obesity Study was not adjusted by age.</p></caption><graphic xlink:href="nihms536922f2"></graphic></fig><table-wrap id="T1" position="float" orientation="portrait"><label>Table 1</label><caption><p>Novel loci reaching genome-wide significance (P < 5 × 10<sup>-8</sup>) for the tails of anthropometric traits and clinical classes of obesity</p></caption><table frame="below" rules="groups"><thead><tr><th align="center" colspan="7" rowspan="1"></th><th align="center" colspan="4" rowspan="1">Stage 1</th><th align="center" colspan="4" rowspan="1">Stage 2<xref rid="TFN1" ref-type="table-fn">*</xref></th><th align="center" colspan="4" rowspan="1">Stage 1 + Stage 2</th></tr><tr><th align="center" colspan="19" valign="bottom" rowspan="1"><hr></hr></th></tr><tr><th align="left" rowspan="1" colspan="1">SNP</th><th align="center" rowspan="1" colspan="1">Chr</th><th align="center" rowspan="1" colspan="1">Position</th><th align="center" rowspan="1" colspan="1">Nearby gene</th><th align="center" rowspan="1" colspan="1">Effect<break></break>allele</th><th align="center" rowspan="1" colspan="1">Other<break></break>allele</th><th align="center" rowspan="1" colspan="1">Effect<break></break>allele freq</th><th align="center" rowspan="1" colspan="1">No.<break></break>cases</th><th align="center" rowspan="1" colspan="1">No.<break></break>controls</th><th align="center" rowspan="1" colspan="1">OR</th><th align="center" rowspan="1" colspan="1">P</th><th align="center" rowspan="1" colspan="1">No.<break></break>cases</th><th align="center" rowspan="1" colspan="1">No.<break></break>controls</th><th align="center" rowspan="1" colspan="1">OR</th><th align="center" rowspan="1" colspan="1">P</th><th align="center" rowspan="1" colspan="1">No.<break></break>cases</th><th align="center" rowspan="1" colspan="1">No.<break></break>controls</th><th align="center" rowspan="1" colspan="1">OR</th><th align="center" rowspan="1" colspan="1">P</th></tr></thead><tbody><tr><td align="left" colspan="19" valign="bottom" rowspan="1"><bold><italic>Height tails</italic></bold><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">rs584438</td><td align="center" rowspan="1" colspan="1">17</td><td align="center" rowspan="1" colspan="1">35852698</td><td align="center" rowspan="1" colspan="1"><italic>IGFBP4</italic></td><td align="center" rowspan="1" colspan="1">c</td><td align="center" rowspan="1" colspan="1">a</td><td align="center" rowspan="1" colspan="1">0.617</td><td align="center" rowspan="1" colspan="1">7830</td><td align="center" rowspan="1" colspan="1">7850</td><td align="center" rowspan="1" colspan="1">1.18</td><td align="center" rowspan="1" colspan="1">1.11E-09</td><td align="center" rowspan="1" colspan="1">1814</td><td align="center" rowspan="1" colspan="1">1814</td><td align="center" rowspan="1" colspan="1">1.19</td><td align="center" rowspan="1" colspan="1">0.001</td><td align="center" rowspan="1" colspan="1">9644</td><td align="center" rowspan="1" colspan="1">9664</td><td align="center" rowspan="1" colspan="1">1.18</td><td align="center" rowspan="1" colspan="1">5.22E-12</td></tr><tr><td align="left" rowspan="1" colspan="1">rs6662509</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">9240191</td><td align="center" rowspan="1" colspan="1"><italic>H6PD</italic></td><td align="center" rowspan="1" colspan="1">t</td><td align="center" rowspan="1" colspan="1">c</td><td align="center" rowspan="1" colspan="1">0.1463</td><td align="center" rowspan="1" colspan="1">5462</td><td align="center" rowspan="1" colspan="1">5461</td><td align="center" rowspan="1" colspan="1">1.23</td><td align="center" rowspan="1" colspan="1">2.21E-06</td><td align="center" rowspan="1" colspan="1">3615</td><td align="center" rowspan="1" colspan="1">3566</td><td align="center" rowspan="1" colspan="1">1.23</td><td align="center" rowspan="1" colspan="1">3.37E-05</td><td align="center" rowspan="1" colspan="1">9077</td><td align="center" rowspan="1" colspan="1">9027</td><td align="center" rowspan="1" colspan="1">1.23</td><td align="center" rowspan="1" colspan="1">3.19E-10</td></tr><tr><td align="left" rowspan="1" colspan="1">rs2362965</td><td align="center" rowspan="1" colspan="1">3</td><td align="center" rowspan="1" colspan="1">159592073</td><td align="center" rowspan="1" colspan="1"><italic>RSRC1/SHOX2</italic></td><td align="center" rowspan="1" colspan="1">t</td><td align="center" rowspan="1" colspan="1">a</td><td align="center" rowspan="1" colspan="1">0.50</td><td align="center" rowspan="1" colspan="1">7989</td><td align="center" rowspan="1" colspan="1">7993</td><td align="center" rowspan="1" colspan="1">1.14</td><td align="center" rowspan="1" colspan="1">1.45E-07</td><td align="center" rowspan="1" colspan="1">4819</td><td align="center" rowspan="1" colspan="1">4775</td><td align="center" rowspan="1" colspan="1">1.10</td><td align="center" rowspan="1" colspan="1">0.002</td><td align="center" rowspan="1" colspan="1">12808</td><td align="center" rowspan="1" colspan="1">12768</td><td align="center" rowspan="1" colspan="1">1.12</td><td align="center" rowspan="1" colspan="1">2.14E-09</td></tr><tr><td align="left" rowspan="1" colspan="1">rs1594829</td><td align="center" rowspan="1" colspan="1">8</td><td align="center" rowspan="1" colspan="1">26261994</td><td align="center" rowspan="1" colspan="1"><italic>PPP2R2A</italic></td><td align="center" rowspan="1" colspan="1">c</td><td align="center" rowspan="1" colspan="1">t</td><td align="center" rowspan="1" colspan="1">0.7688</td><td align="center" rowspan="1" colspan="1">6693</td><td align="center" rowspan="1" colspan="1">6697</td><td align="center" rowspan="1" colspan="1">1.18</td><td align="center" rowspan="1" colspan="1">5.51E-07</td><td align="center" rowspan="1" colspan="1">4166</td><td align="center" rowspan="1" colspan="1">4115</td><td align="center" rowspan="1" colspan="1">1.11</td><td align="center" rowspan="1" colspan="1">0.01</td><td align="center" rowspan="1" colspan="1">10859</td><td align="center" rowspan="1" colspan="1">10812</td><td align="center" rowspan="1" colspan="1">1.15</td><td align="center" rowspan="1" colspan="1">3.88E-08</td></tr><tr><td align="center" colspan="19" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" colspan="19" valign="bottom" rowspan="1"><bold><italic>Obesity Class 2</italic></bold><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">rs7989336</td><td align="center" rowspan="1" colspan="1">13</td><td align="center" rowspan="1" colspan="1">95815549</td><td align="center" rowspan="1" colspan="1"><italic>HS6ST3</italic></td><td align="center" rowspan="1" colspan="1">a</td><td align="center" rowspan="1" colspan="1">g</td><td align="center" rowspan="1" colspan="1">0.4704</td><td align="center" rowspan="1" colspan="1">9825</td><td align="center" rowspan="1" colspan="1">62114</td><td align="center" rowspan="1" colspan="1">1.12</td><td align="center" rowspan="1" colspan="1">5.88E-09</td><td align="center" rowspan="1" colspan="1">1664</td><td align="center" rowspan="1" colspan="1">17113</td><td align="center" rowspan="1" colspan="1">1.04</td><td align="center" rowspan="1" colspan="1">0.25</td><td align="center" rowspan="1" colspan="1">11489</td><td align="center" rowspan="1" colspan="1">79226</td><td align="center" rowspan="1" colspan="1">1.10</td><td align="center" rowspan="1" colspan="1">1.06E-08</td></tr><tr><td align="left" rowspan="1" colspan="1">rs17381664</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">77820919</td><td align="center" rowspan="1" colspan="1"><italic>ZZZ3</italic></td><td align="center" rowspan="1" colspan="1">c</td><td align="center" rowspan="1" colspan="1">t</td><td align="center" rowspan="1" colspan="1">0.3923</td><td align="center" rowspan="1" colspan="1">9833</td><td align="center" rowspan="1" colspan="1">62114</td><td align="center" rowspan="1" colspan="1">1.11</td><td align="center" rowspan="1" colspan="1">7.61E-08</td><td align="center" rowspan="1" colspan="1">5351</td><td align="center" rowspan="1" colspan="1">33841</td><td align="center" rowspan="1" colspan="1">1.05</td><td align="center" rowspan="1" colspan="1">0.04</td><td align="center" rowspan="1" colspan="1">15184</td><td align="center" rowspan="1" colspan="1">95955</td><td align="center" rowspan="1" colspan="1">1.09</td><td align="center" rowspan="1" colspan="1">2.85E-08</td></tr><tr><td align="center" colspan="19" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" colspan="19" valign="bottom" rowspan="1"><bold><italic>Obesity Class 1</italic></bold><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">rs17024258</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">109948844</td><td align="center" rowspan="1" colspan="1"><italic>GNAT2</italic></td><td align="center" rowspan="1" colspan="1">t</td><td align="center" rowspan="1" colspan="1">c</td><td align="center" rowspan="1" colspan="1">0.0364</td><td align="center" rowspan="1" colspan="1">18662</td><td align="center" rowspan="1" colspan="1">38427</td><td align="center" rowspan="1" colspan="1">1.23</td><td align="center" rowspan="1" colspan="1">1.41E-06</td><td align="center" rowspan="1" colspan="1">8956</td><td align="center" rowspan="1" colspan="1">15471</td><td align="center" rowspan="1" colspan="1">1.28</td><td align="center" rowspan="1" colspan="1">1.12E-06</td><td align="center" rowspan="1" colspan="1">27618</td><td align="center" rowspan="1" colspan="1">53898</td><td align="center" rowspan="1" colspan="1">1.25</td><td align="center" rowspan="1" colspan="1">8.66E-12</td></tr><tr><td align="left" rowspan="1" colspan="1">rs4735692</td><td align="center" rowspan="1" colspan="1">8</td><td align="center" rowspan="1" colspan="1">76778218</td><td align="center" rowspan="1" colspan="1"><italic>HNF4G</italic></td><td align="center" rowspan="1" colspan="1">a</td><td align="center" rowspan="1" colspan="1">g</td><td align="center" rowspan="1" colspan="1">0.5834</td><td align="center" rowspan="1" colspan="1">32675</td><td align="center" rowspan="1" colspan="1">65697</td><td align="center" rowspan="1" colspan="1">1.07</td><td align="center" rowspan="1" colspan="1">5.03E-08</td><td align="center" rowspan="1" colspan="1">22086</td><td align="center" rowspan="1" colspan="1">38352</td><td align="center" rowspan="1" colspan="1">1.04</td><td align="center" rowspan="1" colspan="1">0.005</td><td align="center" rowspan="1" colspan="1">54761</td><td align="center" rowspan="1" colspan="1">104049</td><td align="center" rowspan="1" colspan="1">1.06</td><td align="center" rowspan="1" colspan="1">2.48E-09</td></tr><tr><td align="left" rowspan="1" colspan="1">rs13041126</td><td align="center" rowspan="1" colspan="1">20</td><td align="center" rowspan="1" colspan="1">50526403</td><td align="center" rowspan="1" colspan="1"><italic>MRPS33P4</italic></td><td align="center" rowspan="1" colspan="1">t</td><td align="center" rowspan="1" colspan="1">c</td><td align="center" rowspan="1" colspan="1">0.7179</td><td align="center" rowspan="1" colspan="1">32020</td><td align="center" rowspan="1" colspan="1">64015</td><td align="center" rowspan="1" colspan="1">1.07</td><td align="center" rowspan="1" colspan="1">3.05E-07</td><td align="center" rowspan="1" colspan="1">22088</td><td align="center" rowspan="1" colspan="1">37595</td><td align="center" rowspan="1" colspan="1">1.04</td><td align="center" rowspan="1" colspan="1">0.007</td><td align="center" rowspan="1" colspan="1">54108</td><td align="center" rowspan="1" colspan="1">101610</td><td align="center" rowspan="1" colspan="1">1.06</td><td align="center" rowspan="1" colspan="1">2.16E-08</td></tr><tr><td align="left" rowspan="1" colspan="1">rs2531995</td><td align="center" rowspan="1" colspan="1">16</td><td align="center" rowspan="1" colspan="1">3953468</td><td align="center" rowspan="1" colspan="1"><italic>ADCY9</italic></td><td align="center" rowspan="1" colspan="1">t</td><td align="center" rowspan="1" colspan="1">c</td><td align="center" rowspan="1" colspan="1">0.6146</td><td align="center" rowspan="1" colspan="1">32433</td><td align="center" rowspan="1" colspan="1">65542</td><td align="center" rowspan="1" colspan="1">1.06</td><td align="center" rowspan="1" colspan="1">3.17E-06</td><td align="center" rowspan="1" colspan="1">6680</td><td align="center" rowspan="1" colspan="1">16602</td><td align="center" rowspan="1" colspan="1">1.07</td><td align="center" rowspan="1" colspan="1">0.004</td><td align="center" rowspan="1" colspan="1">39113</td><td align="center" rowspan="1" colspan="1">82144</td><td align="center" rowspan="1" colspan="1">1.07</td><td align="center" rowspan="1" colspan="1">4.04E-08</td></tr><tr><td align="center" colspan="19" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" colspan="19" valign="bottom" rowspan="1"><bold><italic>Overweight</italic></bold><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">rs4735692</td><td align="center" rowspan="1" colspan="1">8</td><td align="center" rowspan="1" colspan="1">76778218</td><td align="center" rowspan="1" colspan="1"><italic>HNF4G</italic></td><td align="center" rowspan="1" colspan="1">a</td><td align="center" rowspan="1" colspan="1">g</td><td align="center" rowspan="1" colspan="1">0.5839</td><td align="center" rowspan="1" colspan="1">92703</td><td align="center" rowspan="1" colspan="1">65698</td><td align="center" rowspan="1" colspan="1">1.05</td><td align="center" rowspan="1" colspan="1">6.13E-09</td><td align="center" rowspan="1" colspan="1">65323</td><td align="center" rowspan="1" colspan="1">39290</td><td align="center" rowspan="1" colspan="1">1.03</td><td align="center" rowspan="1" colspan="1">0.003</td><td align="center" rowspan="1" colspan="1">158026</td><td align="center" rowspan="1" colspan="1">104988</td><td align="center" rowspan="1" colspan="1">1.04</td><td align="center" rowspan="1" colspan="1">3.51E-10</td></tr><tr><td align="left" rowspan="1" colspan="1">rs7503807</td><td align="center" rowspan="1" colspan="1">17</td><td align="center" rowspan="1" colspan="1">76205706</td><td align="center" rowspan="1" colspan="1"><italic>RPTOR</italic></td><td align="center" rowspan="1" colspan="1">a</td><td align="center" rowspan="1" colspan="1">c</td><td align="center" rowspan="1" colspan="1">0.5654</td><td align="center" rowspan="1" colspan="1">92855</td><td align="center" rowspan="1" colspan="1">65723</td><td align="center" rowspan="1" colspan="1">1.04</td><td align="center" rowspan="1" colspan="1">4.20E-06</td><td align="center" rowspan="1" colspan="1">64535</td><td align="center" rowspan="1" colspan="1">38813</td><td align="center" rowspan="1" colspan="1">1.03</td><td align="center" rowspan="1" colspan="1">0.0009</td><td align="center" rowspan="1" colspan="1">157390</td><td align="center" rowspan="1" colspan="1">104536</td><td align="center" rowspan="1" colspan="1">1.04</td><td align="center" rowspan="1" colspan="1">1.98E-08</td></tr></tbody></table><table-wrap-foot><fn id="TFN1"><label>*</label><p>Stage 2 consists of studies with either GWAS and Metabochip data. Not all SNPs were present on Metabochip.</p></fn></table-wrap-foot></table-wrap><table-wrap id="T2" position="float" orientation="portrait"><label>Table 2</label><caption><p>Association results for novel genome-wide significant (P < 5 × 10<sup>-8</sup>) SNPs with height and obesity-related traits</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="3" valign="bottom" colspan="1">SNP</th><th align="center" rowspan="3" valign="bottom" colspan="1">Gene</th><th align="center" rowspan="3" valign="bottom" colspan="1">Effect<break></break>allele</th><th align="center" rowspan="3" valign="bottom" colspan="1">Other<break></break>allele</th><th align="center" colspan="2" valign="bottom" rowspan="1">BMI tails</th><th align="center" colspan="2" valign="bottom" rowspan="1">Obesity class 3</th><th align="center" colspan="2" valign="bottom" rowspan="1">Obesity class 2</th><th align="center" colspan="2" valign="bottom" rowspan="1">Obesity class 1</th><th align="center" colspan="2" valign="bottom" rowspan="1">Overweight</th><th align="center" colspan="2" valign="bottom" rowspan="1">BMI<break></break>(continuous)<xref rid="TFN2" ref-type="table-fn">a</xref></th><th align="center" colspan="2" valign="bottom" rowspan="1">Height tails</th><th align="center" colspan="2" valign="bottom" rowspan="1">Height<break></break>(continuous)<xref rid="TFN2" ref-type="table-fn">a</xref></th></tr><tr><th align="center" colspan="16" valign="bottom" rowspan="1"><hr></hr></th></tr><tr><th align="center" valign="bottom" rowspan="1" colspan="1">OR</th><th align="center" valign="bottom" rowspan="1" colspan="1">P</th><th align="center" valign="bottom" rowspan="1" colspan="1">OR</th><th align="center" valign="bottom" rowspan="1" colspan="1">P</th><th align="center" valign="bottom" rowspan="1" colspan="1">OR</th><th align="center" valign="bottom" rowspan="1" colspan="1">P</th><th align="center" valign="bottom" rowspan="1" colspan="1">OR</th><th align="center" valign="bottom" rowspan="1" colspan="1">P</th><th align="center" valign="bottom" rowspan="1" colspan="1">OR</th><th align="center" valign="bottom" rowspan="1" colspan="1">P</th><th align="center" valign="bottom" rowspan="1" colspan="1">Effect</th><th align="center" valign="bottom" rowspan="1" colspan="1">P-value</th><th align="center" valign="bottom" rowspan="1" colspan="1">OR</th><th align="center" valign="bottom" rowspan="1" colspan="1">P</th><th align="center" valign="bottom" rowspan="1" colspan="1">Effect</th><th align="center" valign="bottom" rowspan="1" colspan="1">P-value</th></tr></thead><tbody><tr><td align="left" colspan="20" valign="bottom" rowspan="1"><bold>Height tails</bold><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">rs584438</td><td align="center" rowspan="1" colspan="1"><italic>IGFBP4</italic></td><td align="center" rowspan="1" colspan="1">c</td><td align="center" rowspan="1" colspan="1">a</td><td align="center" rowspan="1" colspan="1">0.98</td><td align="center" rowspan="1" colspan="1">0.52</td><td align="center" rowspan="1" colspan="1">1.02</td><td align="center" rowspan="1" colspan="1">0.64</td><td align="center" rowspan="1" colspan="1">1.01</td><td align="center" rowspan="1" colspan="1">0.47</td><td align="center" rowspan="1" colspan="1">1.00</td><td align="center" rowspan="1" colspan="1">0.75</td><td align="center" rowspan="1" colspan="1">1.00</td><td align="center" rowspan="1" colspan="1">0.59</td><td align="center" rowspan="1" colspan="1">0.005</td><td align="center" rowspan="1" colspan="1">0.22</td><td align="center" rowspan="1" colspan="1">1.18</td><td align="center" rowspan="1" colspan="1">5.22E-12</td><td align="center" rowspan="1" colspan="1">0.025</td><td align="center" rowspan="1" colspan="1">9.43E-11</td></tr><tr><td align="left" rowspan="1" colspan="1">rs6662509</td><td align="center" rowspan="1" colspan="1"><italic>H6PD</italic></td><td align="center" rowspan="1" colspan="1">t</td><td align="center" rowspan="1" colspan="1">c</td><td align="center" rowspan="1" colspan="1">1.00</td><td align="center" rowspan="1" colspan="1">0.95</td><td align="center" rowspan="1" colspan="1">1.11</td><td align="center" rowspan="1" colspan="1">0.07</td><td align="center" rowspan="1" colspan="1">1.01</td><td align="center" rowspan="1" colspan="1">0.83</td><td align="center" rowspan="1" colspan="1">0.99</td><td align="center" rowspan="1" colspan="1">0.34</td><td align="center" rowspan="1" colspan="1">0.99</td><td align="center" rowspan="1" colspan="1">0.35</td><td align="center" rowspan="1" colspan="1">-0.006</td><td align="center" rowspan="1" colspan="1">0.27</td><td align="center" rowspan="1" colspan="1">1.23</td><td align="center" rowspan="1" colspan="1">3.19E-10</td><td align="center" rowspan="1" colspan="1">0.031</td><td align="center" rowspan="1" colspan="1">7.76E-12</td></tr><tr><td align="left" rowspan="1" colspan="1">rs2362965</td><td align="center" rowspan="1" colspan="1"><italic>RSRC1/SHOX2</italic></td><td align="center" rowspan="1" colspan="1">t</td><td align="center" rowspan="1" colspan="1">a</td><td align="center" rowspan="1" colspan="1">0.95</td><td align="center" rowspan="1" colspan="1">0.02</td><td align="center" rowspan="1" colspan="1">0.97</td><td align="center" rowspan="1" colspan="1">0.25</td><td align="center" rowspan="1" colspan="1">0.98</td><td align="center" rowspan="1" colspan="1">0.20</td><td align="center" rowspan="1" colspan="1">0.99</td><td align="center" rowspan="1" colspan="1">0.37</td><td align="center" rowspan="1" colspan="1">0.99</td><td align="center" rowspan="1" colspan="1">0.21</td><td align="center" rowspan="1" colspan="1">-0.007</td><td align="center" rowspan="1" colspan="1">0.05</td><td align="center" rowspan="1" colspan="1">1.12</td><td align="center" rowspan="1" colspan="1">2.14E-09</td><td align="center" rowspan="1" colspan="1">0.017</td><td align="center" rowspan="1" colspan="1">7.07E-08</td></tr><tr><td align="left" rowspan="1" colspan="1">rs1594829</td><td align="center" rowspan="1" colspan="1"><italic>PPP2R2A</italic></td><td align="center" rowspan="1" colspan="1">c</td><td align="center" rowspan="1" colspan="1">t</td><td align="center" rowspan="1" colspan="1">1.03</td><td align="center" rowspan="1" colspan="1">0.33</td><td align="center" rowspan="1" colspan="1">1.06</td><td align="center" rowspan="1" colspan="1">0.11</td><td align="center" rowspan="1" colspan="1">1.01</td><td align="center" rowspan="1" colspan="1">0.58</td><td align="center" rowspan="1" colspan="1">1.00</td><td align="center" rowspan="1" colspan="1">0.82</td><td align="center" rowspan="1" colspan="1">1.01</td><td align="center" rowspan="1" colspan="1">0.32</td><td align="center" rowspan="1" colspan="1">0.004</td><td align="center" rowspan="1" colspan="1">0.33</td><td align="center" rowspan="1" colspan="1">1.15</td><td align="center" rowspan="1" colspan="1">3.88E-08</td><td align="center" rowspan="1" colspan="1">0.016</td><td align="center" rowspan="1" colspan="1">4.29E-05</td></tr><tr><td align="center" colspan="20" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" colspan="20" valign="bottom" rowspan="1"><bold>Obesity Class 2</bold><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">rs7989336</td><td align="center" rowspan="1" colspan="1"><italic>HS6ST3</italic></td><td align="center" rowspan="1" colspan="1">a</td><td align="center" rowspan="1" colspan="1">g</td><td align="center" rowspan="1" colspan="1">1.09</td><td align="center" rowspan="1" colspan="1">0.0001</td><td align="center" rowspan="1" colspan="1">1.11</td><td align="center" rowspan="1" colspan="1">0.0006</td><td align="center" rowspan="1" colspan="1">1.10</td><td align="center" rowspan="1" colspan="1">1.06E-08</td><td align="center" rowspan="1" colspan="1">1.04</td><td align="center" rowspan="1" colspan="1">9.38E-05</td><td align="center" rowspan="1" colspan="1">1.04</td><td align="center" rowspan="1" colspan="1">2.33E-06</td><td align="center" rowspan="1" colspan="1">0.016</td><td align="center" rowspan="1" colspan="1">8.80E-06</td><td align="center" rowspan="1" colspan="1">1.00</td><td align="center" rowspan="1" colspan="1">0.89</td><td align="center" rowspan="1" colspan="1">-0.001</td><td align="center" rowspan="1" colspan="1">0.71</td></tr><tr><td align="left" rowspan="1" colspan="1">rs17381664</td><td align="center" rowspan="1" colspan="1"><italic>ZZZ3</italic></td><td align="center" rowspan="1" colspan="1">c</td><td align="center" rowspan="1" colspan="1">t</td><td align="center" rowspan="1" colspan="1">1.08</td><td align="center" rowspan="1" colspan="1">0.0001</td><td align="center" rowspan="1" colspan="1">1.12</td><td align="center" rowspan="1" colspan="1">5.41E-05</td><td align="center" rowspan="1" colspan="1">1.09</td><td align="center" rowspan="1" colspan="1">2.85E-08</td><td align="center" rowspan="1" colspan="1">1.05</td><td align="center" rowspan="1" colspan="1">6.80E-08</td><td align="center" rowspan="1" colspan="1">1.04</td><td align="center" rowspan="1" colspan="1">2.23E-07</td><td align="center" rowspan="1" colspan="1">0.022</td><td align="center" rowspan="1" colspan="1">2.50E-11</td><td align="center" rowspan="1" colspan="1">1.06</td><td align="center" rowspan="1" colspan="1">0.005</td><td align="center" rowspan="1" colspan="1">0.010</td><td align="center" rowspan="1" colspan="1">0.004</td></tr><tr><td align="center" colspan="20" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" colspan="20" valign="bottom" rowspan="1"><bold>Obesity Class 1</bold><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">rs17024258</td><td align="center" rowspan="1" colspan="1"><italic>GNAT2</italic></td><td align="center" rowspan="1" colspan="1">t</td><td align="center" rowspan="1" colspan="1">c</td><td align="center" rowspan="1" colspan="1">1.27</td><td align="center" rowspan="1" colspan="1">0.02</td><td align="center" rowspan="1" colspan="1">1.45</td><td align="center" rowspan="1" colspan="1">0.002</td><td align="center" rowspan="1" colspan="1">1.26</td><td align="center" rowspan="1" colspan="1">7.73E-05</td><td align="center" rowspan="1" colspan="1">1.25</td><td align="center" rowspan="1" colspan="1">8.66E-12</td><td align="center" rowspan="1" colspan="1">1.13</td><td align="center" rowspan="1" colspan="1">1.41E-08</td><td align="center" rowspan="1" colspan="1">0.067</td><td align="center" rowspan="1" colspan="1">4.34E-14</td><td align="center" rowspan="1" colspan="1">1.21</td><td align="center" rowspan="1" colspan="1">0.08</td><td align="center" rowspan="1" colspan="1">0.010</td><td align="center" rowspan="1" colspan="1">0.36</td></tr><tr><td align="left" rowspan="1" colspan="1">rs4735692</td><td align="center" rowspan="1" colspan="1"><italic>HNF4G</italic></td><td align="center" rowspan="1" colspan="1">a</td><td align="center" rowspan="1" colspan="1">g</td><td align="center" rowspan="1" colspan="1">1.09</td><td align="center" rowspan="1" colspan="1">1.97E-05</td><td align="center" rowspan="1" colspan="1">1.08</td><td align="center" rowspan="1" colspan="1">0.006</td><td align="center" rowspan="1" colspan="1">1.05</td><td align="center" rowspan="1" colspan="1">0.0005</td><td align="center" rowspan="1" colspan="1">1.06</td><td align="center" rowspan="1" colspan="1">2.48E-09</td><td align="center" rowspan="1" colspan="1">1.04</td><td align="center" rowspan="1" colspan="1">3.51E-10</td><td align="center" rowspan="1" colspan="1">0.019</td><td align="center" rowspan="1" colspan="1">9.94E-10</td><td align="center" rowspan="1" colspan="1">1.02</td><td align="center" rowspan="1" colspan="1">0.50</td><td align="center" rowspan="1" colspan="1">0.006</td><td align="center" rowspan="1" colspan="1">0.10</td></tr><tr><td align="left" rowspan="1" colspan="1">rs13041126</td><td align="center" rowspan="1" colspan="1"><italic>MRPS33P4</italic></td><td align="center" rowspan="1" colspan="1">t</td><td align="center" rowspan="1" colspan="1">c</td><td align="center" rowspan="1" colspan="1">1.08</td><td align="center" rowspan="1" colspan="1">0.001</td><td align="center" rowspan="1" colspan="1">1.05</td><td align="center" rowspan="1" colspan="1">0.16</td><td align="center" rowspan="1" colspan="1">1.06</td><td align="center" rowspan="1" colspan="1">0.0002</td><td align="center" rowspan="1" colspan="1">1.06</td><td align="center" rowspan="1" colspan="1">2.16E-08</td><td align="center" rowspan="1" colspan="1">1.04</td><td align="center" rowspan="1" colspan="1">1.43E-06</td><td align="center" rowspan="1" colspan="1">0.017</td><td align="center" rowspan="1" colspan="1">8.52E-07</td><td align="center" rowspan="1" colspan="1">1.02</td><td align="center" rowspan="1" colspan="1">0.56</td><td align="center" rowspan="1" colspan="1">0.002</td><td align="center" rowspan="1" colspan="1">0.65</td></tr><tr><td align="left" rowspan="1" colspan="1">rs2531995</td><td align="center" rowspan="1" colspan="1"><italic>ADCY9</italic></td><td align="center" rowspan="1" colspan="1">t</td><td align="center" rowspan="1" colspan="1">c</td><td align="center" rowspan="1" colspan="1">1.06</td><td align="center" rowspan="1" colspan="1">0.01</td><td align="center" rowspan="1" colspan="1">1.09</td><td align="center" rowspan="1" colspan="1">0.006</td><td align="center" rowspan="1" colspan="1">1.06</td><td align="center" rowspan="1" colspan="1">0.001</td><td align="center" rowspan="1" colspan="1">1.07</td><td align="center" rowspan="1" colspan="1">4.04E-08</td><td align="center" rowspan="1" colspan="1">1.03</td><td align="center" rowspan="1" colspan="1">5.57E-05</td><td align="center" rowspan="1" colspan="1">0.021</td><td align="center" rowspan="1" colspan="1">6.58E-08</td><td align="center" rowspan="1" colspan="1">1.07</td><td align="center" rowspan="1" colspan="1">0.005</td><td align="center" rowspan="1" colspan="1">0.018</td><td align="center" rowspan="1" colspan="1">1.87E-06</td></tr><tr><td align="center" colspan="20" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" colspan="20" valign="bottom" rowspan="1"><bold>Overweight</bold><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">rs4735692</td><td align="center" rowspan="1" colspan="1"><italic>HNF4G</italic></td><td align="center" rowspan="1" colspan="1">a</td><td align="center" rowspan="1" colspan="1">g</td><td align="center" rowspan="1" colspan="1">1.09</td><td align="center" rowspan="1" colspan="1">1.97E-05</td><td align="center" rowspan="1" colspan="1">1.08</td><td align="center" rowspan="1" colspan="1">0.006</td><td align="center" rowspan="1" colspan="1">1.05</td><td align="center" rowspan="1" colspan="1">0.0005</td><td align="center" rowspan="1" colspan="1">1.06</td><td align="center" rowspan="1" colspan="1">2.48E-09</td><td align="center" rowspan="1" colspan="1">1.04</td><td align="center" rowspan="1" colspan="1">3.51E-10</td><td align="center" rowspan="1" colspan="1">0.019</td><td align="center" rowspan="1" colspan="1">9.94E-10</td><td align="center" rowspan="1" colspan="1">1.02</td><td align="center" rowspan="1" colspan="1">0.50</td><td align="center" rowspan="1" colspan="1">0.006</td><td align="center" rowspan="1" colspan="1">0.10</td></tr><tr><td align="left" rowspan="1" colspan="1">rs7503807</td><td align="center" rowspan="1" colspan="1"><italic>RPTOR</italic></td><td align="center" rowspan="1" colspan="1">a</td><td align="center" rowspan="1" colspan="1">c</td><td align="center" rowspan="1" colspan="1">1.08</td><td align="center" rowspan="1" colspan="1">7.07E-05</td><td align="center" rowspan="1" colspan="1">1.13</td><td align="center" rowspan="1" colspan="1">9.44E-06</td><td align="center" rowspan="1" colspan="1">1.07</td><td align="center" rowspan="1" colspan="1">2.46E-06</td><td align="center" rowspan="1" colspan="1">1.05</td><td align="center" rowspan="1" colspan="1">1.12E-07</td><td align="center" rowspan="1" colspan="1">1.04</td><td align="center" rowspan="1" colspan="1">1.98E-08</td><td align="center" rowspan="1" colspan="1">0.020</td><td align="center" rowspan="1" colspan="1">3.00E-10</td><td align="center" rowspan="1" colspan="1">0.99</td><td align="center" rowspan="1" colspan="1">0.55</td><td align="center" rowspan="1" colspan="1">-0.001</td><td align="center" rowspan="1" colspan="1">0.85</td></tr></tbody></table><table-wrap-foot><fn id="TFN2"><label>a</label><p>The beta represents the difference in standardized effects.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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