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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genome-wide association analysis identifies three new breast cancer susceptibility loci</title><author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="A2">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name><affiliation><nlm:aff id="A4">Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K" last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="A5">Department of Experimental Therapy, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Department of Epidemiology, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Dicks, Ed" sort="Dicks, Ed" uniqKey="Dicks E" first="Ed" last="Dicks">Ed Dicks</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Humphreys, Manjeet K" sort="Humphreys, Manjeet K" uniqKey="Humphreys M" first="Manjeet K" last="Humphreys">Manjeet K. Humphreys</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Luccarini, Craig" sort="Luccarini, Craig" uniqKey="Luccarini C" first="Craig" last="Luccarini">Craig Luccarini</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Baynes, Caroline" sort="Baynes, Caroline" uniqKey="Baynes C" first="Caroline" last="Baynes">Caroline Baynes</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Conroy, Don" sort="Conroy, Don" uniqKey="Conroy D" first="Don" last="Conroy">Don Conroy</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Maranian, Melanie" sort="Maranian, Melanie" uniqKey="Maranian M" first="Melanie" last="Maranian">Melanie Maranian</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Ahmed, Shahana" sort="Ahmed, Shahana" uniqKey="Ahmed S" first="Shahana" last="Ahmed">Shahana Ahmed</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Driver, Kristy" sort="Driver, Kristy" uniqKey="Driver K" first="Kristy" last="Driver">Kristy Driver</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="A2">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Orr, Nicholas" sort="Orr, Nicholas" uniqKey="Orr N" first="Nicholas" last="Orr">Nicholas Orr</name><affiliation><nlm:aff id="A2">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Silva, Isabel Dos Santos" sort="Silva, Isabel Dos Santos" uniqKey="Silva I" first="Isabel Dos Santos" last="Silva">Isabel Dos Santos Silva</name><affiliation><nlm:aff id="A7">Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Waisfisz, Quinten" sort="Waisfisz, Quinten" uniqKey="Waisfisz Q" first="Quinten" last="Waisfisz">Quinten Waisfisz</name><affiliation><nlm:aff id="A8">Department of Clinical Genetics, VU University Medical Center, section Oncogenetics, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Meijers Heijboer, Hanne" sort="Meijers Heijboer, Hanne" uniqKey="Meijers Heijboer H" first="Hanne" last="Meijers-Heijboer">Hanne Meijers-Heijboer</name><affiliation><nlm:aff id="A8">Department of Clinical Genetics, VU University Medical Center, section Oncogenetics, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation><nlm:aff id="A9">Department of Internal Medicine and Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="A9">Department of Internal Medicine and Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="A11">Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="A11">Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Irwanto, Astrid" sort="Irwanto, Astrid" uniqKey="Irwanto A" first="Astrid" last="Irwanto">Astrid Irwanto</name><affiliation><nlm:aff id="A13">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:aff id="A12">Human Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A13">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="A14">Department of Clinical Genetics, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="A15">Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A16">Clinic of Gynaecology and Obstetrics, Division for Gynaecological Tumor-Genetics, Technische Universität München, München, Germany</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K" last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A17">Department of Obstetrics and Gynaecology, Division of Molecular Gynaeco-Oncology, University of Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name><affiliation><nlm:aff id="A18">Max Planck Institute of Psychiatry, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Lichtner, Peter" sort="Lichtner, Peter" uniqKey="Lichtner P" first="Peter" last="Lichtner">Peter Lichtner</name><affiliation><nlm:aff id="A19">Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A20">Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name><affiliation><nlm:aff id="A20">Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A21">PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Nickels, Stefan" sort="Nickels, Stefan" uniqKey="Nickels S" first="Stefan" last="Nickels">Stefan Nickels</name><affiliation><nlm:aff id="A20">Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="A22">Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Tsimiklis, Helen" sort="Tsimiklis, Helen" uniqKey="Tsimiklis H" first="Helen" last="Tsimiklis">Helen Tsimiklis</name><affiliation><nlm:aff id="A24">Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><affiliation><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Daniel" sort="Schmidt, Daniel" uniqKey="Schmidt D" first="Daniel" last="Schmidt">Daniel Schmidt</name><affiliation><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Bui, Minh" sort="Bui, Minh" uniqKey="Bui M" first="Minh" last="Bui">Minh Bui</name><affiliation><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Park, Daniel J" sort="Park, Daniel J" uniqKey="Park D" first="Daniel J" last="Park">Daniel J. Park</name><affiliation><nlm:aff id="A24">Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa" sort="Southey, Melissa" uniqKey="Southey M" first="Melissa" last="Southey">Melissa Southey</name><affiliation><nlm:aff id="A24">Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="A26">Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="A27">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="A5">Department of Experimental Therapy, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Verhoef, Senno" sort="Verhoef, Senno" uniqKey="Verhoef S" first="Senno" last="Verhoef">Senno Verhoef</name><affiliation><nlm:aff id="A28">Department of Clinical Genetics, Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hogervorst, Frans Bl" sort="Hogervorst, Frans Bl" uniqKey="Hogervorst F" first="Frans Bl" last="Hogervorst">Frans Bl Hogervorst</name><affiliation><nlm:aff id="A29">Department of Molecular Pathology, Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="A30">University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Lux, Michael P" sort="Lux, Michael P" uniqKey="Lux M" first="Michael P." last="Lux">Michael P. Lux</name><affiliation><nlm:aff id="A30">University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="A30">University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="A31">Institute of Human Genetics, Friedrich-Alexander University Erlangen Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor" sort="Sawyer, Elinor" uniqKey="Sawyer E" first="Elinor" last="Sawyer">Elinor Sawyer</name><affiliation><nlm:aff id="A32">Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust in partnership with King’s College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="A33">Welcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Kerin, Michael" sort="Kerin, Michael" uniqKey="Kerin M" first="Michael" last="Kerin">Michael Kerin</name><affiliation><nlm:aff id="A34">Clinical Science Institute, University Hospital Galway, Galway, Ireland</nlm:aff></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation><nlm:aff id="A35">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A36">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name><affiliation><nlm:aff id="A35">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A36">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name><affiliation><nlm:aff id="A35">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="A35">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Molecular Epidemiology Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="A38">Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Université Paris-Sud, UMRS 1018, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="A38">Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Université Paris-Sud, UMRS 1018, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Cordina Duverger, Emilie" sort="Cordina Duverger, Emilie" uniqKey="Cordina Duverger E" first="Emilie" last="Cordina-Duverger">Emilie Cordina-Duverger</name><affiliation><nlm:aff id="A38">Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Université Paris-Sud, UMRS 1018, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name><affiliation><nlm:aff id="A38">Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Université Paris-Sud, UMRS 1018, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E" last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="A40">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A41">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G" last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="A40">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A41">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F" last="Nielsen">Sune F. Nielsen</name><affiliation><nlm:aff id="A40">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A41">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="A42">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="A43">Genetic & Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Alonso, M Rosario" sort="Alonso, M Rosario" uniqKey="Alonso M" first="M. Rosario" last="Alonso">M. Rosario Alonso</name><affiliation><nlm:aff id="A44">Human Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation><nlm:aff id="A44">Human Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name><affiliation><nlm:aff id="A45">Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="A46">Department of Epidemiology, University of California Irvine, Irvine, California, USA</nlm:aff></affiliation></author><author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name><affiliation><nlm:aff id="A46">Department of Epidemiology, University of California Irvine, Irvine, California, USA</nlm:aff></affiliation></author><author><name sortKey="Bernstein, Leslie" sort="Bernstein, Leslie" uniqKey="Bernstein L" first="Leslie" last="Bernstein">Leslie Bernstein</name><affiliation><nlm:aff id="A47">City of Hope Cancer Centre, Duarte, California, USA</nlm:aff></affiliation></author><author><name sortKey="Dur, Christina Clarke" sort="Dur, Christina Clarke" uniqKey="Dur C" first="Christina Clarke" last="Dur">Christina Clarke Dur</name><affiliation><nlm:aff id="A48">Cancer Prevention Institute of California, Fremont, California, USA</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="A49">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center [DKFZ], Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Muller, Heiko" sort="Muller, Heiko" uniqKey="Muller H" first="Heiko" last="Müller">Heiko Müller</name><affiliation><nlm:aff id="A49">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center [DKFZ], Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="A49">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center [DKFZ], Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation><nlm:aff id="A50">Saarland Cancer Registry, Saarbrücken, Germany</nlm:aff></affiliation></author><author><name sortKey="Justenhoven, Christina" sort="Justenhoven, Christina" uniqKey="Justenhoven C" first="Christina" last="Justenhoven">Christina Justenhoven</name><affiliation><nlm:aff id="A51">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart</nlm:aff></affiliation><affiliation><nlm:aff id="A52">University of Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="A51">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart</nlm:aff></affiliation><affiliation><nlm:aff id="A52">University of Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation><nlm:aff id="A53">Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum, Germany</nlm:aff></affiliation></author><author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name><affiliation><nlm:aff id="A56">Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Eilber, Ursula" sort="Eilber, Ursula" uniqKey="Eilber U" first="Ursula" last="Eilber">Ursula Eilber</name><affiliation><nlm:aff id="A20">Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="A57">Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Schurmann, Peter" sort="Schurmann, Peter" uniqKey="Schurmann P" first="Peter" last="Schürmann">Peter Schürmann</name><affiliation><nlm:aff id="A57">Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Bremer, Michael" sort="Bremer, Michael" uniqKey="Bremer M" first="Michael" last="Bremer">Michael Bremer</name><affiliation><nlm:aff id="A57">Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Hillemanns, Peter" sort="Hillemanns, Peter" uniqKey="Hillemanns P" first="Peter" last="Hillemanns">Peter Hillemanns</name><affiliation><nlm:aff id="A57">Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation><nlm:aff id="A58">Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Antonenkova, Natalia N" sort="Antonenkova, Natalia N" uniqKey="Antonenkova N" first="Natalia N." last="Antonenkova">Natalia N. Antonenkova</name><affiliation><nlm:aff id="A59">N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus</nlm:aff></affiliation></author><author><name sortKey="Rogov, Yuri I" sort="Rogov, Yuri I" uniqKey="Rogov Y" first="Yuri I." last="Rogov">Yuri I. Rogov</name><affiliation><nlm:aff id="A59">N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus</nlm:aff></affiliation></author><author><name sortKey="Karstens, Johann H" sort="Karstens, Johann H" uniqKey="Karstens J" first="Johann H." last="Karstens">Johann H. Karstens</name><affiliation><nlm:aff id="A58">Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Bermisheva, Marina" sort="Bermisheva, Marina" uniqKey="Bermisheva M" first="Marina" last="Bermisheva">Marina Bermisheva</name><affiliation><nlm:aff id="A60">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</nlm:aff></affiliation></author><author><name sortKey="Prokofieva, Darya" sort="Prokofieva, Darya" uniqKey="Prokofieva D" first="Darya" last="Prokofieva">Darya Prokofieva</name><affiliation><nlm:aff id="A60">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</nlm:aff></affiliation></author><author><name sortKey="Khusnutdinova, Elza" sort="Khusnutdinova, Elza" uniqKey="Khusnutdinova E" first="Elza" last="Khusnutdinova">Elza Khusnutdinova</name><affiliation><nlm:aff id="A60">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="A61">Department Molecular Medicine and Surgery, Karolinska Institutet, Stockholm</nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="A62">Department Onkologi-pathology, Karolinska Institutet, Stockholm</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="A63">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A64">Biocenter Kuopio, Kuopio Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation><nlm:aff id="A64">Biocenter Kuopio, Kuopio Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A66">School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Department of Oncology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="A63">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A64">Biocenter Kuopio, Kuopio Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M" last="Hartikainen">Jaana M. Hartikainen</name><affiliation><nlm:aff id="A63">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A64">Biocenter Kuopio, Kuopio Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="A68">Vesalius Research Center [VRC], VIB, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Yesilyurt, Betul T" sort="Yesilyurt, Betul T" uniqKey="Yesilyurt B" first="Betul T." last="Yesilyurt">Betul T. Yesilyurt</name><affiliation><nlm:aff id="A68">Vesalius Research Center [VRC], VIB, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Floris, Giuseppe" sort="Floris, Giuseppe" uniqKey="Floris G" first="Giuseppe" last="Floris">Giuseppe Floris</name><affiliation><nlm:aff id="A69">Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Leunen, Karin" sort="Leunen, Karin" uniqKey="Leunen K" first="Karin" last="Leunen">Karin Leunen</name><affiliation><nlm:aff id="A69">Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="A70">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name><affiliation><nlm:aff id="A71">Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Fortuzzi, Stefano" sort="Fortuzzi, Stefano" uniqKey="Fortuzzi S" first="Stefano" last="Fortuzzi">Stefano Fortuzzi</name><affiliation><nlm:aff id="A72">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A73">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy and IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J" last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A74">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A75">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff id="A74">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Stevens, Kristen" sort="Stevens, Kristen" uniqKey="Stevens K" first="Kristen" last="Stevens">Kristen Stevens</name><affiliation><nlm:aff id="A75">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Lee, Adam" sort="Lee, Adam" uniqKey="Lee A" first="Adam" last="Lee">Adam Lee</name><affiliation><nlm:aff id="A76">Department of Pharmacology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name><affiliation><nlm:aff id="A78">Department of Anatomical Pathology, Alfred Hospital, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Aln S, Grethe Grenaker" sort="Aln S, Grethe Grenaker" uniqKey="Aln S G" first="Grethe Grenaker" last="Aln S">Grethe Grenaker Aln S</name><affiliation><nlm:aff id="A79">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation><nlm:aff id="A79">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A80">Institute for Clinical Medicine, Faculty of Medicine, UiO, Norway</nlm:aff></affiliation></author><author><name sortKey="B Rrensen Dale, Anne Lise" sort="B Rrensen Dale, Anne Lise" uniqKey="B Rrensen Dale A" first="Anne-Lise" last="B Rrensen-Dale">Anne-Lise B Rrensen-Dale</name><affiliation><nlm:aff id="A79">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A80">Institute for Clinical Medicine, Faculty of Medicine, UiO, Norway</nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name><affiliation><nlm:aff id="A81">Cancer Prevention Institute of California, Fremont, California, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A82">Stanford University School of Medicine, Stanford, California, USA</nlm:aff></affiliation></author><author><name sortKey="Miron, Alexander" sort="Miron, Alexander" uniqKey="Miron A" first="Alexander" last="Miron">Alexander Miron</name><affiliation><nlm:aff id="A83">Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="A84">Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="A84">Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation><nlm:aff id="A85">Department of Oncology, University of Oulu, Oulu University Hospital, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Kauppila, Saila" sort="Kauppila, Saila" uniqKey="Kauppila S" first="Saila" last="Kauppila">Saila Kauppila</name><affiliation><nlm:aff id="A86">Department of Pathology, University of Oulu, Oulu University Hospital, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A87">Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital</nlm:aff></affiliation><affiliation><nlm:aff id="A88">Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="A89">Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="A90">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Department of Laboratory Medicine, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="A92">Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A93">Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Asperen, Christie J" sort="Van Asperen, Christie J" uniqKey="Van Asperen C" first="Christie J." last="Van Asperen">Christie J. Van Asperen</name><affiliation><nlm:aff id="A94">Department of Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Rob A E M" sort="Tollenaar, Rob A E M" uniqKey="Tollenaar R" first="Rob A. E. M." last="Tollenaar">Rob A. E. M. Tollenaar</name><affiliation><nlm:aff id="A95">Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation><nlm:aff id="A96">Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D" last="Figueroa">Jonine D. Figueroa</name><affiliation><nlm:aff id="A27">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><affiliation><nlm:aff id="A4">Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A97">Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Brinton, Louise" sort="Brinton, Louise" uniqKey="Brinton L" first="Louise" last="Brinton">Louise Brinton</name><affiliation><nlm:aff id="A27">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation><nlm:aff id="A98">Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name><affiliation><nlm:aff id="A99">Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam,The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation><nlm:aff id="A100">Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Oldenburg, Rogier A" sort="Oldenburg, Rogier A" uniqKey="Oldenburg R" first="Rogier A." last="Oldenburg">Rogier A. Oldenburg</name><affiliation><nlm:aff id="A101">Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam,The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Den Ouweland, Ans M W" sort="Van Den Ouweland, Ans M W" uniqKey="Van Den Ouweland A" first="Ans M. W." last="Van Den Ouweland">Ans M. W. Van Den Ouweland</name><affiliation><nlm:aff id="A101">Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam,The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="A102">Institute for Cancer Studies, Department of Oncology, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Reed, Malcolm Wr" sort="Reed, Malcolm Wr" uniqKey="Reed M" first="Malcolm Wr" last="Reed">Malcolm Wr Reed</name><affiliation><nlm:aff id="A103">Academic Unit of Surgical Oncology, Department of Oncology, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Ania" sort="Jakubowska, Ania" uniqKey="Jakubowska A" first="Ania" last="Jakubowska">Ania Jakubowska</name><affiliation><nlm:aff id="A104">International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="A104">International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jaworska, Katarzyna" sort="Jaworska, Katarzyna" uniqKey="Jaworska K" first="Katarzyna" last="Jaworska">Katarzyna Jaworska</name><affiliation><nlm:aff id="A104">International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="A104">International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jones, Michael" sort="Jones, Michael" uniqKey="Jones M" first="Michael" last="Jones">Michael Jones</name><affiliation><nlm:aff id="A97">Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Schoemaker, Minouk" sort="Schoemaker, Minouk" uniqKey="Schoemaker M" first="Minouk" last="Schoemaker">Minouk Schoemaker</name><affiliation><nlm:aff id="A97">Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation><nlm:aff id="A2">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="A97">Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="A105">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name><affiliation><nlm:aff id="A105">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth R" sort="Muir, Kenneth R" uniqKey="Muir K" first="Kenneth R" last="Muir">Kenneth R. Muir</name><affiliation><nlm:aff id="A107">Warwick Medical School, Warwick University, Coventry, UK</nlm:aff></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation><nlm:aff id="A107">Warwick Medical School, Warwick University, Coventry, UK</nlm:aff></affiliation></author><author><name sortKey="Rattanamongkongul, Suthee" sort="Rattanamongkongul, Suthee" uniqKey="Rattanamongkongul S" first="Suthee" last="Rattanamongkongul">Suthee Rattanamongkongul</name><affiliation><nlm:aff id="A108">Department of Preventive Medicine, Srinakhrainwirot University, Ongkharak, Nakhon Nayok,Thailand</nlm:aff></affiliation></author><author><name sortKey="Chaiwerawattana, Arkom" sort="Chaiwerawattana, Arkom" uniqKey="Chaiwerawattana A" first="Arkom" last="Chaiwerawattana">Arkom Chaiwerawattana</name><affiliation><nlm:aff id="A109">Department of Academic support, The National Cancer Institute of Thailand, Ministry of Public Health,Thailand</nlm:aff></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation><nlm:aff id="A110">Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Yoo, Keun Young" sort="Yoo, Keun Young" uniqKey="Yoo K" first="Keun-Young" last="Yoo">Keun-Young Yoo</name><affiliation><nlm:aff id="A110">Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Noh, Dong Young" sort="Noh, Dong Young" uniqKey="Noh D" first="Dong-Young" last="Noh">Dong-Young Noh</name><affiliation><nlm:aff id="A110">Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name><affiliation><nlm:aff id="A111">Institute of Biomedical Sciences, Academia Sinica, Taipei,Taiwan</nlm:aff></affiliation></author><author><name sortKey="Yu, Jyh Cherng" sort="Yu, Jyh Cherng" uniqKey="Yu J" first="Jyh-Cherng" last="Yu">Jyh-Cherng Yu</name><affiliation><nlm:aff id="A112">Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Wu, Pei Ei" sort="Wu, Pei Ei" uniqKey="Wu P" first="Pei-Ei" last="Wu">Pei-Ei Wu</name><affiliation><nlm:aff id="A111">Institute of Biomedical Sciences, Academia Sinica, Taipei,Taiwan</nlm:aff></affiliation></author><author><name sortKey="Hsiung, Chia Ni" sort="Hsiung, Chia Ni" uniqKey="Hsiung C" first="Chia-Ni" last="Hsiung">Chia-Ni Hsiung</name><affiliation><nlm:aff id="A111">Institute of Biomedical Sciences, Academia Sinica, Taipei,Taiwan</nlm:aff></affiliation></author><author><name sortKey="Perkins, Annie" sort="Perkins, Annie" uniqKey="Perkins A" first="Annie" last="Perkins">Annie Perkins</name><affiliation><nlm:aff id="A113">Against Breast Cancer Research Group, Department of Molecular and Applied Biosciences, University of Westminster, London, UK</nlm:aff></affiliation></author><author><name sortKey="Swann, Ruth" sort="Swann, Ruth" uniqKey="Swann R" first="Ruth" last="Swann">Ruth Swann</name><affiliation><nlm:aff id="A113">Against Breast Cancer Research Group, Department of Molecular and Applied Biosciences, University of Westminster, London, UK</nlm:aff></affiliation></author><author><name sortKey="Velentzis, Louiza" sort="Velentzis, Louiza" uniqKey="Velentzis L" first="Louiza" last="Velentzis">Louiza Velentzis</name><affiliation><nlm:aff id="A113">Against Breast Cancer Research Group, Department of Molecular and Applied Biosciences, University of Westminster, London, UK</nlm:aff></affiliation></author><author><name sortKey="Eccles, Diana M" sort="Eccles, Diana M" uniqKey="Eccles D" first="Diana M" last="Eccles">Diana M. Eccles</name><affiliation><nlm:aff id="A114">Faculty of Medicine, University of Southampton, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Tapper, Will J" sort="Tapper, Will J" uniqKey="Tapper W" first="Will J" last="Tapper">Will J. Tapper</name><affiliation><nlm:aff id="A114">Faculty of Medicine, University of Southampton, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Gerty, Susan M" sort="Gerty, Susan M" uniqKey="Gerty S" first="Susan M" last="Gerty">Susan M. Gerty</name><affiliation><nlm:aff id="A114">Faculty of Medicine, University of Southampton, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Graham, Nikki J" sort="Graham, Nikki J" uniqKey="Graham N" first="Nikki J" last="Graham">Nikki J. Graham</name><affiliation><nlm:aff id="A114">Faculty of Medicine, University of Southampton, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Ponder, Bruce A J" sort="Ponder, Bruce A J" uniqKey="Ponder B" first="Bruce A. J." last="Ponder">Bruce A. J. Ponder</name><affiliation><nlm:aff id="A115">Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A116">CRUK Cambridge Research Institute, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A105">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation><nlm:aff id="A117">Centre National de Genotypage, Evry, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A118">Fondation Jean Dausset – CEPH, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation><nlm:aff id="A4">Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="A7">Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22267197</idno><idno type="pmc">3653403</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653403</idno><idno type="RBID">PMC:3653403</idno><idno type="doi">10.1038/ng.1049</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002E10</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E10</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide association analysis identifies three new breast cancer susceptibility loci</title><author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="A2">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name><affiliation><nlm:aff id="A4">Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K" last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="A5">Department of Experimental Therapy, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Department of Epidemiology, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Dicks, Ed" sort="Dicks, Ed" uniqKey="Dicks E" first="Ed" last="Dicks">Ed Dicks</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Humphreys, Manjeet K" sort="Humphreys, Manjeet K" uniqKey="Humphreys M" first="Manjeet K" last="Humphreys">Manjeet K. Humphreys</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Luccarini, Craig" sort="Luccarini, Craig" uniqKey="Luccarini C" first="Craig" last="Luccarini">Craig Luccarini</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Baynes, Caroline" sort="Baynes, Caroline" uniqKey="Baynes C" first="Caroline" last="Baynes">Caroline Baynes</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Conroy, Don" sort="Conroy, Don" uniqKey="Conroy D" first="Don" last="Conroy">Don Conroy</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Maranian, Melanie" sort="Maranian, Melanie" uniqKey="Maranian M" first="Melanie" last="Maranian">Melanie Maranian</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Ahmed, Shahana" sort="Ahmed, Shahana" uniqKey="Ahmed S" first="Shahana" last="Ahmed">Shahana Ahmed</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Driver, Kristy" sort="Driver, Kristy" uniqKey="Driver K" first="Kristy" last="Driver">Kristy Driver</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="A2">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Orr, Nicholas" sort="Orr, Nicholas" uniqKey="Orr N" first="Nicholas" last="Orr">Nicholas Orr</name><affiliation><nlm:aff id="A2">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Silva, Isabel Dos Santos" sort="Silva, Isabel Dos Santos" uniqKey="Silva I" first="Isabel Dos Santos" last="Silva">Isabel Dos Santos Silva</name><affiliation><nlm:aff id="A7">Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Waisfisz, Quinten" sort="Waisfisz, Quinten" uniqKey="Waisfisz Q" first="Quinten" last="Waisfisz">Quinten Waisfisz</name><affiliation><nlm:aff id="A8">Department of Clinical Genetics, VU University Medical Center, section Oncogenetics, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Meijers Heijboer, Hanne" sort="Meijers Heijboer, Hanne" uniqKey="Meijers Heijboer H" first="Hanne" last="Meijers-Heijboer">Hanne Meijers-Heijboer</name><affiliation><nlm:aff id="A8">Department of Clinical Genetics, VU University Medical Center, section Oncogenetics, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation><nlm:aff id="A9">Department of Internal Medicine and Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="A9">Department of Internal Medicine and Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="A11">Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="A11">Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Irwanto, Astrid" sort="Irwanto, Astrid" uniqKey="Irwanto A" first="Astrid" last="Irwanto">Astrid Irwanto</name><affiliation><nlm:aff id="A13">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:aff id="A12">Human Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A13">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="A14">Department of Clinical Genetics, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="A15">Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A16">Clinic of Gynaecology and Obstetrics, Division for Gynaecological Tumor-Genetics, Technische Universität München, München, Germany</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K" last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A17">Department of Obstetrics and Gynaecology, Division of Molecular Gynaeco-Oncology, University of Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name><affiliation><nlm:aff id="A18">Max Planck Institute of Psychiatry, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Lichtner, Peter" sort="Lichtner, Peter" uniqKey="Lichtner P" first="Peter" last="Lichtner">Peter Lichtner</name><affiliation><nlm:aff id="A19">Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A20">Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name><affiliation><nlm:aff id="A20">Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A21">PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Nickels, Stefan" sort="Nickels, Stefan" uniqKey="Nickels S" first="Stefan" last="Nickels">Stefan Nickels</name><affiliation><nlm:aff id="A20">Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="A22">Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Tsimiklis, Helen" sort="Tsimiklis, Helen" uniqKey="Tsimiklis H" first="Helen" last="Tsimiklis">Helen Tsimiklis</name><affiliation><nlm:aff id="A24">Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><affiliation><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Daniel" sort="Schmidt, Daniel" uniqKey="Schmidt D" first="Daniel" last="Schmidt">Daniel Schmidt</name><affiliation><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Bui, Minh" sort="Bui, Minh" uniqKey="Bui M" first="Minh" last="Bui">Minh Bui</name><affiliation><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Park, Daniel J" sort="Park, Daniel J" uniqKey="Park D" first="Daniel J" last="Park">Daniel J. Park</name><affiliation><nlm:aff id="A24">Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa" sort="Southey, Melissa" uniqKey="Southey M" first="Melissa" last="Southey">Melissa Southey</name><affiliation><nlm:aff id="A24">Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="A26">Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="A27">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="A5">Department of Experimental Therapy, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Verhoef, Senno" sort="Verhoef, Senno" uniqKey="Verhoef S" first="Senno" last="Verhoef">Senno Verhoef</name><affiliation><nlm:aff id="A28">Department of Clinical Genetics, Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hogervorst, Frans Bl" sort="Hogervorst, Frans Bl" uniqKey="Hogervorst F" first="Frans Bl" last="Hogervorst">Frans Bl Hogervorst</name><affiliation><nlm:aff id="A29">Department of Molecular Pathology, Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="A30">University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Lux, Michael P" sort="Lux, Michael P" uniqKey="Lux M" first="Michael P." last="Lux">Michael P. Lux</name><affiliation><nlm:aff id="A30">University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="A30">University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="A31">Institute of Human Genetics, Friedrich-Alexander University Erlangen Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor" sort="Sawyer, Elinor" uniqKey="Sawyer E" first="Elinor" last="Sawyer">Elinor Sawyer</name><affiliation><nlm:aff id="A32">Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust in partnership with King’s College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="A33">Welcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Kerin, Michael" sort="Kerin, Michael" uniqKey="Kerin M" first="Michael" last="Kerin">Michael Kerin</name><affiliation><nlm:aff id="A34">Clinical Science Institute, University Hospital Galway, Galway, Ireland</nlm:aff></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation><nlm:aff id="A35">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A36">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name><affiliation><nlm:aff id="A35">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A36">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name><affiliation><nlm:aff id="A35">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="A35">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Molecular Epidemiology Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="A38">Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Université Paris-Sud, UMRS 1018, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="A38">Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Université Paris-Sud, UMRS 1018, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Cordina Duverger, Emilie" sort="Cordina Duverger, Emilie" uniqKey="Cordina Duverger E" first="Emilie" last="Cordina-Duverger">Emilie Cordina-Duverger</name><affiliation><nlm:aff id="A38">Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Université Paris-Sud, UMRS 1018, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name><affiliation><nlm:aff id="A38">Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Université Paris-Sud, UMRS 1018, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E" last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="A40">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A41">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G" last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="A40">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A41">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F" last="Nielsen">Sune F. Nielsen</name><affiliation><nlm:aff id="A40">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A41">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="A42">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="A43">Genetic & Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Alonso, M Rosario" sort="Alonso, M Rosario" uniqKey="Alonso M" first="M. Rosario" last="Alonso">M. Rosario Alonso</name><affiliation><nlm:aff id="A44">Human Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation><nlm:aff id="A44">Human Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name><affiliation><nlm:aff id="A45">Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="A46">Department of Epidemiology, University of California Irvine, Irvine, California, USA</nlm:aff></affiliation></author><author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name><affiliation><nlm:aff id="A46">Department of Epidemiology, University of California Irvine, Irvine, California, USA</nlm:aff></affiliation></author><author><name sortKey="Bernstein, Leslie" sort="Bernstein, Leslie" uniqKey="Bernstein L" first="Leslie" last="Bernstein">Leslie Bernstein</name><affiliation><nlm:aff id="A47">City of Hope Cancer Centre, Duarte, California, USA</nlm:aff></affiliation></author><author><name sortKey="Dur, Christina Clarke" sort="Dur, Christina Clarke" uniqKey="Dur C" first="Christina Clarke" last="Dur">Christina Clarke Dur</name><affiliation><nlm:aff id="A48">Cancer Prevention Institute of California, Fremont, California, USA</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="A49">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center [DKFZ], Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Muller, Heiko" sort="Muller, Heiko" uniqKey="Muller H" first="Heiko" last="Müller">Heiko Müller</name><affiliation><nlm:aff id="A49">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center [DKFZ], Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="A49">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center [DKFZ], Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation><nlm:aff id="A50">Saarland Cancer Registry, Saarbrücken, Germany</nlm:aff></affiliation></author><author><name sortKey="Justenhoven, Christina" sort="Justenhoven, Christina" uniqKey="Justenhoven C" first="Christina" last="Justenhoven">Christina Justenhoven</name><affiliation><nlm:aff id="A51">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart</nlm:aff></affiliation><affiliation><nlm:aff id="A52">University of Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="A51">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart</nlm:aff></affiliation><affiliation><nlm:aff id="A52">University of Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation><nlm:aff id="A53">Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum, Germany</nlm:aff></affiliation></author><author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name><affiliation><nlm:aff id="A56">Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Eilber, Ursula" sort="Eilber, Ursula" uniqKey="Eilber U" first="Ursula" last="Eilber">Ursula Eilber</name><affiliation><nlm:aff id="A20">Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="A57">Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Schurmann, Peter" sort="Schurmann, Peter" uniqKey="Schurmann P" first="Peter" last="Schürmann">Peter Schürmann</name><affiliation><nlm:aff id="A57">Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Bremer, Michael" sort="Bremer, Michael" uniqKey="Bremer M" first="Michael" last="Bremer">Michael Bremer</name><affiliation><nlm:aff id="A57">Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Hillemanns, Peter" sort="Hillemanns, Peter" uniqKey="Hillemanns P" first="Peter" last="Hillemanns">Peter Hillemanns</name><affiliation><nlm:aff id="A57">Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation><nlm:aff id="A58">Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Antonenkova, Natalia N" sort="Antonenkova, Natalia N" uniqKey="Antonenkova N" first="Natalia N." last="Antonenkova">Natalia N. Antonenkova</name><affiliation><nlm:aff id="A59">N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus</nlm:aff></affiliation></author><author><name sortKey="Rogov, Yuri I" sort="Rogov, Yuri I" uniqKey="Rogov Y" first="Yuri I." last="Rogov">Yuri I. Rogov</name><affiliation><nlm:aff id="A59">N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus</nlm:aff></affiliation></author><author><name sortKey="Karstens, Johann H" sort="Karstens, Johann H" uniqKey="Karstens J" first="Johann H." last="Karstens">Johann H. Karstens</name><affiliation><nlm:aff id="A58">Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Bermisheva, Marina" sort="Bermisheva, Marina" uniqKey="Bermisheva M" first="Marina" last="Bermisheva">Marina Bermisheva</name><affiliation><nlm:aff id="A60">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</nlm:aff></affiliation></author><author><name sortKey="Prokofieva, Darya" sort="Prokofieva, Darya" uniqKey="Prokofieva D" first="Darya" last="Prokofieva">Darya Prokofieva</name><affiliation><nlm:aff id="A60">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</nlm:aff></affiliation></author><author><name sortKey="Khusnutdinova, Elza" sort="Khusnutdinova, Elza" uniqKey="Khusnutdinova E" first="Elza" last="Khusnutdinova">Elza Khusnutdinova</name><affiliation><nlm:aff id="A60">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="A61">Department Molecular Medicine and Surgery, Karolinska Institutet, Stockholm</nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="A62">Department Onkologi-pathology, Karolinska Institutet, Stockholm</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="A63">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A64">Biocenter Kuopio, Kuopio Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation><nlm:aff id="A64">Biocenter Kuopio, Kuopio Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A66">School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Department of Oncology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="A63">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A64">Biocenter Kuopio, Kuopio Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M" last="Hartikainen">Jaana M. Hartikainen</name><affiliation><nlm:aff id="A63">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A64">Biocenter Kuopio, Kuopio Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="A68">Vesalius Research Center [VRC], VIB, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Yesilyurt, Betul T" sort="Yesilyurt, Betul T" uniqKey="Yesilyurt B" first="Betul T." last="Yesilyurt">Betul T. Yesilyurt</name><affiliation><nlm:aff id="A68">Vesalius Research Center [VRC], VIB, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Floris, Giuseppe" sort="Floris, Giuseppe" uniqKey="Floris G" first="Giuseppe" last="Floris">Giuseppe Floris</name><affiliation><nlm:aff id="A69">Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Leunen, Karin" sort="Leunen, Karin" uniqKey="Leunen K" first="Karin" last="Leunen">Karin Leunen</name><affiliation><nlm:aff id="A69">Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="A70">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name><affiliation><nlm:aff id="A71">Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Fortuzzi, Stefano" sort="Fortuzzi, Stefano" uniqKey="Fortuzzi S" first="Stefano" last="Fortuzzi">Stefano Fortuzzi</name><affiliation><nlm:aff id="A72">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A73">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy and IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J" last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A74">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A75">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff id="A74">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Stevens, Kristen" sort="Stevens, Kristen" uniqKey="Stevens K" first="Kristen" last="Stevens">Kristen Stevens</name><affiliation><nlm:aff id="A75">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Lee, Adam" sort="Lee, Adam" uniqKey="Lee A" first="Adam" last="Lee">Adam Lee</name><affiliation><nlm:aff id="A76">Department of Pharmacology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name><affiliation><nlm:aff id="A78">Department of Anatomical Pathology, Alfred Hospital, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Aln S, Grethe Grenaker" sort="Aln S, Grethe Grenaker" uniqKey="Aln S G" first="Grethe Grenaker" last="Aln S">Grethe Grenaker Aln S</name><affiliation><nlm:aff id="A79">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation><nlm:aff id="A79">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A80">Institute for Clinical Medicine, Faculty of Medicine, UiO, Norway</nlm:aff></affiliation></author><author><name sortKey="B Rrensen Dale, Anne Lise" sort="B Rrensen Dale, Anne Lise" uniqKey="B Rrensen Dale A" first="Anne-Lise" last="B Rrensen-Dale">Anne-Lise B Rrensen-Dale</name><affiliation><nlm:aff id="A79">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A80">Institute for Clinical Medicine, Faculty of Medicine, UiO, Norway</nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name><affiliation><nlm:aff id="A81">Cancer Prevention Institute of California, Fremont, California, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A82">Stanford University School of Medicine, Stanford, California, USA</nlm:aff></affiliation></author><author><name sortKey="Miron, Alexander" sort="Miron, Alexander" uniqKey="Miron A" first="Alexander" last="Miron">Alexander Miron</name><affiliation><nlm:aff id="A83">Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="A84">Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="A84">Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation><nlm:aff id="A85">Department of Oncology, University of Oulu, Oulu University Hospital, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Kauppila, Saila" sort="Kauppila, Saila" uniqKey="Kauppila S" first="Saila" last="Kauppila">Saila Kauppila</name><affiliation><nlm:aff id="A86">Department of Pathology, University of Oulu, Oulu University Hospital, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A87">Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital</nlm:aff></affiliation><affiliation><nlm:aff id="A88">Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="A89">Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="A90">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Department of Laboratory Medicine, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="A92">Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A93">Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Asperen, Christie J" sort="Van Asperen, Christie J" uniqKey="Van Asperen C" first="Christie J." last="Van Asperen">Christie J. Van Asperen</name><affiliation><nlm:aff id="A94">Department of Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Rob A E M" sort="Tollenaar, Rob A E M" uniqKey="Tollenaar R" first="Rob A. E. M." last="Tollenaar">Rob A. E. M. Tollenaar</name><affiliation><nlm:aff id="A95">Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation><nlm:aff id="A96">Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D" last="Figueroa">Jonine D. Figueroa</name><affiliation><nlm:aff id="A27">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><affiliation><nlm:aff id="A4">Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A97">Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Brinton, Louise" sort="Brinton, Louise" uniqKey="Brinton L" first="Louise" last="Brinton">Louise Brinton</name><affiliation><nlm:aff id="A27">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation><nlm:aff id="A98">Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name><affiliation><nlm:aff id="A99">Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam,The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation><nlm:aff id="A100">Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Oldenburg, Rogier A" sort="Oldenburg, Rogier A" uniqKey="Oldenburg R" first="Rogier A." last="Oldenburg">Rogier A. Oldenburg</name><affiliation><nlm:aff id="A101">Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam,The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Den Ouweland, Ans M W" sort="Van Den Ouweland, Ans M W" uniqKey="Van Den Ouweland A" first="Ans M. W." last="Van Den Ouweland">Ans M. W. Van Den Ouweland</name><affiliation><nlm:aff id="A101">Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam,The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="A102">Institute for Cancer Studies, Department of Oncology, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Reed, Malcolm Wr" sort="Reed, Malcolm Wr" uniqKey="Reed M" first="Malcolm Wr" last="Reed">Malcolm Wr Reed</name><affiliation><nlm:aff id="A103">Academic Unit of Surgical Oncology, Department of Oncology, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Ania" sort="Jakubowska, Ania" uniqKey="Jakubowska A" first="Ania" last="Jakubowska">Ania Jakubowska</name><affiliation><nlm:aff id="A104">International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="A104">International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jaworska, Katarzyna" sort="Jaworska, Katarzyna" uniqKey="Jaworska K" first="Katarzyna" last="Jaworska">Katarzyna Jaworska</name><affiliation><nlm:aff id="A104">International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="A104">International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jones, Michael" sort="Jones, Michael" uniqKey="Jones M" first="Michael" last="Jones">Michael Jones</name><affiliation><nlm:aff id="A97">Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Schoemaker, Minouk" sort="Schoemaker, Minouk" uniqKey="Schoemaker M" first="Minouk" last="Schoemaker">Minouk Schoemaker</name><affiliation><nlm:aff id="A97">Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation><nlm:aff id="A2">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="A97">Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="A105">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name><affiliation><nlm:aff id="A105">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth R" sort="Muir, Kenneth R" uniqKey="Muir K" first="Kenneth R" last="Muir">Kenneth R. Muir</name><affiliation><nlm:aff id="A107">Warwick Medical School, Warwick University, Coventry, UK</nlm:aff></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation><nlm:aff id="A107">Warwick Medical School, Warwick University, Coventry, UK</nlm:aff></affiliation></author><author><name sortKey="Rattanamongkongul, Suthee" sort="Rattanamongkongul, Suthee" uniqKey="Rattanamongkongul S" first="Suthee" last="Rattanamongkongul">Suthee Rattanamongkongul</name><affiliation><nlm:aff id="A108">Department of Preventive Medicine, Srinakhrainwirot University, Ongkharak, Nakhon Nayok,Thailand</nlm:aff></affiliation></author><author><name sortKey="Chaiwerawattana, Arkom" sort="Chaiwerawattana, Arkom" uniqKey="Chaiwerawattana A" first="Arkom" last="Chaiwerawattana">Arkom Chaiwerawattana</name><affiliation><nlm:aff id="A109">Department of Academic support, The National Cancer Institute of Thailand, Ministry of Public Health,Thailand</nlm:aff></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation><nlm:aff id="A110">Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Yoo, Keun Young" sort="Yoo, Keun Young" uniqKey="Yoo K" first="Keun-Young" last="Yoo">Keun-Young Yoo</name><affiliation><nlm:aff id="A110">Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Noh, Dong Young" sort="Noh, Dong Young" uniqKey="Noh D" first="Dong-Young" last="Noh">Dong-Young Noh</name><affiliation><nlm:aff id="A110">Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name><affiliation><nlm:aff id="A111">Institute of Biomedical Sciences, Academia Sinica, Taipei,Taiwan</nlm:aff></affiliation></author><author><name sortKey="Yu, Jyh Cherng" sort="Yu, Jyh Cherng" uniqKey="Yu J" first="Jyh-Cherng" last="Yu">Jyh-Cherng Yu</name><affiliation><nlm:aff id="A112">Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Wu, Pei Ei" sort="Wu, Pei Ei" uniqKey="Wu P" first="Pei-Ei" last="Wu">Pei-Ei Wu</name><affiliation><nlm:aff id="A111">Institute of Biomedical Sciences, Academia Sinica, Taipei,Taiwan</nlm:aff></affiliation></author><author><name sortKey="Hsiung, Chia Ni" sort="Hsiung, Chia Ni" uniqKey="Hsiung C" first="Chia-Ni" last="Hsiung">Chia-Ni Hsiung</name><affiliation><nlm:aff id="A111">Institute of Biomedical Sciences, Academia Sinica, Taipei,Taiwan</nlm:aff></affiliation></author><author><name sortKey="Perkins, Annie" sort="Perkins, Annie" uniqKey="Perkins A" first="Annie" last="Perkins">Annie Perkins</name><affiliation><nlm:aff id="A113">Against Breast Cancer Research Group, Department of Molecular and Applied Biosciences, University of Westminster, London, UK</nlm:aff></affiliation></author><author><name sortKey="Swann, Ruth" sort="Swann, Ruth" uniqKey="Swann R" first="Ruth" last="Swann">Ruth Swann</name><affiliation><nlm:aff id="A113">Against Breast Cancer Research Group, Department of Molecular and Applied Biosciences, University of Westminster, London, UK</nlm:aff></affiliation></author><author><name sortKey="Velentzis, Louiza" sort="Velentzis, Louiza" uniqKey="Velentzis L" first="Louiza" last="Velentzis">Louiza Velentzis</name><affiliation><nlm:aff id="A113">Against Breast Cancer Research Group, Department of Molecular and Applied Biosciences, University of Westminster, London, UK</nlm:aff></affiliation></author><author><name sortKey="Eccles, Diana M" sort="Eccles, Diana M" uniqKey="Eccles D" first="Diana M" last="Eccles">Diana M. Eccles</name><affiliation><nlm:aff id="A114">Faculty of Medicine, University of Southampton, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Tapper, Will J" sort="Tapper, Will J" uniqKey="Tapper W" first="Will J" last="Tapper">Will J. Tapper</name><affiliation><nlm:aff id="A114">Faculty of Medicine, University of Southampton, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Gerty, Susan M" sort="Gerty, Susan M" uniqKey="Gerty S" first="Susan M" last="Gerty">Susan M. Gerty</name><affiliation><nlm:aff id="A114">Faculty of Medicine, University of Southampton, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Graham, Nikki J" sort="Graham, Nikki J" uniqKey="Graham N" first="Nikki J" last="Graham">Nikki J. Graham</name><affiliation><nlm:aff id="A114">Faculty of Medicine, University of Southampton, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Ponder, Bruce A J" sort="Ponder, Bruce A J" uniqKey="Ponder B" first="Bruce A. J." last="Ponder">Bruce A. J. Ponder</name><affiliation><nlm:aff id="A115">Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A116">CRUK Cambridge Research Institute, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A105">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation><nlm:aff id="A117">Centre National de Genotypage, Evry, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A118">Fondation Jean Dausset – CEPH, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation><nlm:aff id="A4">Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="A7">Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Breast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility loci have been identified accounting for ~ 8% of the heritability of the disease. We followed up 72 promising associations from two independent Genome Wide Association Studies (GWAS) in ~70,000 cases and ~68,000 controls from 41 case-control studies and nine breast cancer GWAS. We identified three new breast cancer risk loci on 12p11 (rs10771399; <italic>P</italic>=2.7 × 10<sup>−35</sup>), 12q24 (rs1292011; <italic>P</italic>=4.3×10<sup>−19</sup>) and 21q21 (rs2823093; <italic>P</italic>=1.1×10<sup>−12</sup>). SNP rs10771399 was associated with similar relative risks for both estrogen receptor (ER)-negative and ER-positive breast cancer, whereas the other two loci were associated only with ER-positive disease. Two of the loci lie in regions that contain strong plausible candidate genes: <italic>PTHLH</italic> (12p11) plays a crucial role in mammary gland development and the establishment of bone metastasis in breast cancer, while <italic>NRIP1</italic> (21q21) encodes an ER co-factor and has a role in the regulation of breast cancer cell growth.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kamangar, F" uniqKey="Kamangar F">F Kamangar</name></author><author><name sortKey="Dores, Gm" uniqKey="Dores G">GM Dores</name></author><author><name sortKey="Anderson, Wf" uniqKey="Anderson W">WF Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lichtenstein, P" uniqKey="Lichtenstein P">P Lichtenstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peto, J" uniqKey="Peto J">J Peto</name></author><author><name sortKey="Mack, Tm" uniqKey="Mack T">TM 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<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id><journal-id journal-id-type="pubmed-jr-id">2419</journal-id><journal-id journal-id-type="nlm-ta">Nat Genet</journal-id><journal-id journal-id-type="iso-abbrev">Nat. 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rid="A102">102</xref></contrib><contrib contrib-type="author"><name><surname>Reed</surname><given-names>Malcolm WR</given-names></name><xref ref-type="aff" rid="A103">103</xref></contrib><contrib contrib-type="author"><name><surname>Shah</surname><given-names>Mitul</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Jakubowska</surname><given-names>Ania</given-names></name><xref ref-type="aff" rid="A104">104</xref></contrib><contrib contrib-type="author"><name><surname>Lubinski</surname><given-names>Jan</given-names></name><xref ref-type="aff" rid="A104">104</xref></contrib><contrib contrib-type="author"><name><surname>Jaworska</surname><given-names>Katarzyna</given-names></name><xref ref-type="aff" rid="A104">104</xref></contrib><contrib contrib-type="author"><name><surname>Durda</surname><given-names>Katarzyna</given-names></name><xref ref-type="aff" rid="A104">104</xref></contrib><contrib contrib-type="author"><name><surname>Jones</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="A97">97</xref></contrib><contrib contrib-type="author"><name><surname>Schoemaker</surname><given-names>Minouk</given-names></name><xref ref-type="aff" rid="A97">97</xref></contrib><contrib contrib-type="author"><name><surname>Ashworth</surname><given-names>Alan</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Swerdlow</surname><given-names>Anthony</given-names></name><xref ref-type="aff" rid="A97">97</xref></contrib><contrib contrib-type="author"><name><surname>Beesley</surname><given-names>Jonathan</given-names></name><xref ref-type="aff" rid="A105">105</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Xiaoqing</given-names></name><xref ref-type="aff" rid="A105">105</xref></contrib><contrib contrib-type="author"><collab>kConFab Investigators</collab><xref ref-type="aff" rid="A106">106</xref></contrib><contrib contrib-type="author"><collab>Australian Ovarian Cancer Study Group</collab><xref ref-type="aff" rid="A106">106</xref></contrib><contrib contrib-type="author"><name><surname>Muir</surname><given-names>Kenneth R</given-names></name><xref ref-type="aff" rid="A107">107</xref></contrib><contrib contrib-type="author"><name><surname>Lophatananon</surname><given-names>Artitaya</given-names></name><xref ref-type="aff" rid="A107">107</xref></contrib><contrib contrib-type="author"><name><surname>Rattanamongkongul</surname><given-names>Suthee</given-names></name><xref ref-type="aff" rid="A108">108</xref></contrib><contrib contrib-type="author"><name><surname>Chaiwerawattana</surname><given-names>Arkom</given-names></name><xref ref-type="aff" rid="A109">109</xref></contrib><contrib contrib-type="author"><name><surname>Kang</surname><given-names>Daehee</given-names></name><xref ref-type="aff" rid="A110">110</xref></contrib><contrib contrib-type="author"><name><surname>Yoo</surname><given-names>Keun-Young</given-names></name><xref ref-type="aff" rid="A110">110</xref></contrib><contrib contrib-type="author"><name><surname>Noh</surname><given-names>Dong-Young</given-names></name><xref ref-type="aff" rid="A110">110</xref></contrib><contrib contrib-type="author"><name><surname>Shen</surname><given-names>Chen-Yang</given-names></name><xref ref-type="aff" rid="A111">111</xref></contrib><contrib contrib-type="author"><name><surname>Yu</surname><given-names>Jyh-Cherng</given-names></name><xref ref-type="aff" rid="A112">112</xref></contrib><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Pei-Ei</given-names></name><xref ref-type="aff" rid="A111">111</xref></contrib><contrib contrib-type="author"><name><surname>Hsiung</surname><given-names>Chia-Ni</given-names></name><xref ref-type="aff" rid="A111">111</xref></contrib><contrib contrib-type="author"><name><surname>Perkins</surname><given-names>Annie</given-names></name><xref ref-type="aff" rid="A113">113</xref></contrib><contrib contrib-type="author"><name><surname>Swann</surname><given-names>Ruth</given-names></name><xref ref-type="aff" rid="A113">113</xref></contrib><contrib contrib-type="author"><name><surname>Velentzis</surname><given-names>Louiza</given-names></name><xref ref-type="aff" rid="A113">113</xref></contrib><contrib contrib-type="author"><name><surname>Eccles</surname><given-names>Diana M</given-names></name><xref ref-type="aff" rid="A114">114</xref></contrib><contrib contrib-type="author"><name><surname>Tapper</surname><given-names>Will J</given-names></name><xref ref-type="aff" rid="A114">114</xref></contrib><contrib contrib-type="author"><name><surname>Gerty</surname><given-names>Susan M</given-names></name><xref ref-type="aff" rid="A114">114</xref></contrib><contrib contrib-type="author"><name><surname>Graham</surname><given-names>Nikki J</given-names></name><xref ref-type="aff" rid="A114">114</xref></contrib><contrib contrib-type="author"><name><surname>Ponder</surname><given-names>Bruce A. J.</given-names></name><xref ref-type="aff" rid="A115">115</xref><xref ref-type="aff" rid="A116">116</xref></contrib><contrib contrib-type="author"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><xref ref-type="aff" rid="A105">105</xref></contrib><contrib contrib-type="author"><name><surname>Pharoah</surname><given-names>Paul D.P.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Lathrop</surname><given-names>Mark</given-names></name><xref ref-type="aff" rid="A117">117</xref><xref ref-type="aff" rid="A118">118</xref></contrib><contrib contrib-type="author"><name><surname>Dunning</surname><given-names>Alison M.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Rahman</surname><given-names>Nazneen</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Peto</surname><given-names>Julian</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</aff><aff id="A2"><label>2</label>Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</aff><aff id="A3"><label>3</label>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</aff><aff id="A4"><label>4</label>Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK</aff><aff id="A5"><label>5</label>Department of Experimental Therapy, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</aff><aff id="A6"><label>6</label>Department of Epidemiology, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</aff><aff id="A7"><label>7</label>Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.</aff><aff id="A8"><label>8</label>Department of Clinical Genetics, VU University Medical Center, section Oncogenetics, Amsterdam, The Netherlands</aff><aff id="A9"><label>9</label>Department of Internal Medicine and Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</aff><aff id="A10"><label>10</label>Netherlands Collaborative Group on Hereditary Breast and Ovarian Cancer</aff><aff id="A11"><label>11</label>Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</aff><aff id="A12"><label>12</label>Human Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore</aff><aff id="A13"><label>13</label>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A14"><label>14</label>Department of Clinical Genetics, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A15"><label>15</label>Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A16"><label>16</label>Clinic of Gynaecology and Obstetrics, Division for Gynaecological Tumor-Genetics, Technische Universität München, München, Germany</aff><aff id="A17"><label>17</label>Department of Obstetrics and Gynaecology, Division of Molecular Gynaeco-Oncology, University of Cologne, Germany</aff><aff id="A18"><label>18</label>Max Planck Institute of Psychiatry, Munich, Germany</aff><aff id="A19"><label>19</label>Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="A20"><label>20</label>Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany</aff><aff id="A21"><label>21</label>PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany</aff><aff id="A22"><label>22</label>Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany</aff><aff id="A23"><label>23</label>Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</aff><aff id="A24"><label>24</label>Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Australia</aff><aff id="A25"><label>25</label>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</aff><aff id="A26"><label>26</label>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</aff><aff id="A27"><label>27</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA</aff><aff id="A28"><label>28</label>Department of Clinical Genetics, Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</aff><aff id="A29"><label>29</label>Department of Molecular Pathology, Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</aff><aff id="A30"><label>30</label>University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany</aff><aff id="A31"><label>31</label>Institute of Human Genetics, Friedrich-Alexander University Erlangen Nuremberg, Erlangen, Germany</aff><aff id="A32"><label>32</label>Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust in partnership with King’s College London, London, UK</aff><aff id="A33"><label>33</label>Welcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, UK</aff><aff id="A34"><label>34</label>Clinical Science Institute, University Hospital Galway, Galway, Ireland</aff><aff id="A35"><label>35</label>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</aff><aff id="A36"><label>36</label>National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</aff><aff id="A37"><label>37</label>Molecular Epidemiology Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A38"><label>38</label>Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif, France</aff><aff id="A39"><label>39</label>Université Paris-Sud, UMRS 1018, Villejuif, France</aff><aff id="A40"><label>40</label>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</aff><aff id="A41"><label>41</label>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</aff><aff id="A42"><label>42</label>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</aff><aff id="A43"><label>43</label>Genetic & Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</aff><aff id="A44"><label>44</label>Human Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</aff><aff id="A45"><label>45</label>Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</aff><aff id="A46"><label>46</label>Department of Epidemiology, University of California Irvine, Irvine, California, USA</aff><aff id="A47"><label>47</label>City of Hope Cancer Centre, Duarte, California, USA</aff><aff id="A48"><label>48</label>Cancer Prevention Institute of California, Fremont, California, USA</aff><aff id="A49"><label>49</label>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center [DKFZ], Heidelberg, Germany</aff><aff id="A50"><label>50</label>Saarland Cancer Registry, Saarbrücken, Germany</aff><aff id="A51"><label>51</label>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart</aff><aff id="A52"><label>52</label>University of Tübingen, Germany</aff><aff id="A53"><label>53</label>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum, Germany</aff><aff id="A54"><label>54</label>Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany</aff><aff id="A55"><label>55</label>Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany</aff><aff id="A56"><label>56</label>Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</aff><aff id="A57"><label>57</label>Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</aff><aff id="A58"><label>58</label>Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</aff><aff id="A59"><label>59</label>N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus</aff><aff id="A60"><label>60</label>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</aff><aff id="A61"><label>61</label>Department Molecular Medicine and Surgery, Karolinska Institutet, Stockholm</aff><aff id="A62"><label>62</label>Department Onkologi-pathology, Karolinska Institutet, Stockholm</aff><aff id="A63"><label>63</label>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</aff><aff id="A64"><label>64</label>Biocenter Kuopio, Kuopio Finland</aff><aff id="A65"><label>65</label>Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</aff><aff id="A66"><label>66</label>School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, Kuopio, Finland</aff><aff id="A67"><label>67</label>Department of Oncology, Kuopio University Hospital, Kuopio, Finland</aff><aff id="A68"><label>68</label>Vesalius Research Center [VRC], VIB, Leuven, Belgium</aff><aff id="A69"><label>69</label>Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium</aff><aff id="A70"><label>70</label>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</aff><aff id="A71"><label>71</label>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy</aff><aff id="A72"><label>72</label>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</aff><aff id="A73"><label>73</label>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy and IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</aff><aff id="A74"><label>74</label>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</aff><aff id="A75"><label>75</label>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</aff><aff id="A76"><label>76</label>Department of Pharmacology, Mayo Clinic, Rochester, Minnesota, USA</aff><aff id="A77"><label>77</label>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</aff><aff id="A78"><label>78</label>Department of Anatomical Pathology, Alfred Hospital, Melbourne, Australia</aff><aff id="A79"><label>79</label>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</aff><aff id="A80"><label>80</label>Institute for Clinical Medicine, Faculty of Medicine, UiO, Norway</aff><aff id="A81"><label>81</label>Cancer Prevention Institute of California, Fremont, California, USA</aff><aff id="A82"><label>82</label>Stanford University School of Medicine, Stanford, California, USA</aff><aff id="A83"><label>83</label>Dana-Farber Cancer Institute, Boston, Massachusetts, USA</aff><aff id="A84"><label>84</label>Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland.</aff><aff id="A85"><label>85</label>Department of Oncology, University of Oulu, Oulu University Hospital, Oulu, Finland.</aff><aff id="A86"><label>86</label>Department of Pathology, University of Oulu, Oulu University Hospital, Oulu, Finland.</aff><aff id="A87"><label>87</label>Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital</aff><aff id="A88"><label>88</label>Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</aff><aff id="A89"><label>89</label>Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</aff><aff id="A90"><label>90</label>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada</aff><aff id="A91"><label>91</label>Department of Laboratory Medicine, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Ontario, Canada</aff><aff id="A92"><label>92</label>Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands</aff><aff id="A93"><label>93</label>Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands</aff><aff id="A94"><label>94</label>Department of Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands</aff><aff id="A95"><label>95</label>Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands</aff><aff id="A96"><label>96</label>Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</aff><aff id="A97"><label>97</label>Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom</aff><aff id="A98"><label>98</label>Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</aff><aff id="A99"><label>99</label>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam,The Netherlands</aff><aff id="A100"><label>100</label>Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A101"><label>101</label>Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam,The Netherlands</aff><aff id="A102"><label>102</label>Institute for Cancer Studies, Department of Oncology, University of Sheffield, Sheffield, UK</aff><aff id="A103"><label>103</label>Academic Unit of Surgical Oncology, Department of Oncology, University of Sheffield, Sheffield, UK</aff><aff id="A104"><label>104</label>International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</aff><aff id="A105"><label>105</label>Queensland Institute of Medical Research, Brisbane, Australia</aff><aff id="A106"><label>106</label>Peter MacCallum Cancer Center, Melbourne, Australia</aff><aff id="A107"><label>107</label>Warwick Medical School, Warwick University, Coventry, UK</aff><aff id="A108"><label>108</label>Department of Preventive Medicine, Srinakhrainwirot University, Ongkharak, Nakhon Nayok,Thailand</aff><aff id="A109"><label>109</label>Department of Academic support, The National Cancer Institute of Thailand, Ministry of Public Health,Thailand</aff><aff id="A110"><label>110</label>Seoul National University College of Medicine, Seoul, Korea</aff><aff id="A111"><label>111</label>Institute of Biomedical Sciences, Academia Sinica, Taipei,Taiwan</aff><aff id="A112"><label>112</label>Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan</aff><aff id="A113"><label>113</label>Against Breast Cancer Research Group, Department of Molecular and Applied Biosciences, University of Westminster, London, UK</aff><aff id="A114"><label>114</label>Faculty of Medicine, University of Southampton, Southampton, UK</aff><aff id="A115"><label>115</label>Department of Oncology, University of Cambridge, Cambridge, UK</aff><aff id="A116"><label>116</label>CRUK Cambridge Research Institute, Cambridge, UK</aff><aff id="A117"><label>117</label>Centre National de Genotypage, Evry, France.</aff><aff id="A118"><label>118</label>Fondation Jean Dausset – CEPH, Paris, France.</aff><pub-date pub-type="nihms-submitted"><day>6</day><month>2</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>22</day><month>1</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>14</day><month>5</month><year>2013</year></pub-date><volume>44</volume><issue>3</issue><fpage>312</fpage><lpage>318</lpage><permissions><license><license-p>Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:
<uri xlink:type="simple" xlink:href="http://www.nature.com/authors/editorial_policies/license.html#terms">http://www.nature.com/authors/editorial_policies/license.html#terms</uri></license-p></license></permissions><abstract><p id="P1">Breast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility loci have been identified accounting for ~ 8% of the heritability of the disease. We followed up 72 promising associations from two independent Genome Wide Association Studies (GWAS) in ~70,000 cases and ~68,000 controls from 41 case-control studies and nine breast cancer GWAS. We identified three new breast cancer risk loci on 12p11 (rs10771399; <italic>P</italic>=2.7 × 10<sup>−35</sup>), 12q24 (rs1292011; <italic>P</italic>=4.3×10<sup>−19</sup>) and 21q21 (rs2823093; <italic>P</italic>=1.1×10<sup>−12</sup>). SNP rs10771399 was associated with similar relative risks for both estrogen receptor (ER)-negative and ER-positive breast cancer, whereas the other two loci were associated only with ER-positive disease. Two of the loci lie in regions that contain strong plausible candidate genes: <italic>PTHLH</italic> (12p11) plays a crucial role in mammary gland development and the establishment of bone metastasis in breast cancer, while <italic>NRIP1</italic> (21q21) encodes an ER co-factor and has a role in the regulation of breast cancer cell growth.</p></abstract></article-meta></front><body><p id="P2">Breast cancer is one of the most commonly occurring epithelial malignancies in women with an estimated one million new cases and over 400,000 deaths annually worldwide<sup><xref ref-type="bibr" rid="R1">1</xref></sup>. Familial aggregation and twin studies have demonstrated the substantial contribution of inherited susceptibility to breast cancer <sup><xref ref-type="bibr" rid="R2">2</xref>, <xref ref-type="bibr" rid="R3">3</xref></sup>. Over the last four years, we and others have conducted several genome-wide association studies (GWAS) and reported breast cancer susceptibility variants at 21 loci <sup><xref ref-type="bibr" rid="R4">4</xref>-<xref ref-type="bibr" rid="R14">14</xref></sup> with an additional locus (<italic>CASP8</italic>) identified through a candidate gene approach 15. These variants are associated with modest risks of the disease (per-allele odds ratios <1.3), and explain ~ 8% of the excess familial risk of breast cancer, while other rarer high and moderate risk loci contribute less than 20%, suggesting that other loci remain to be identified <sup><xref ref-type="bibr" rid="R16">16</xref></sup>.</p><p id="P3">To identify further breast cancer susceptibility loci, we selected 72 SNPs that were genotyped and found to be significantly associated with breast cancer at <italic>P</italic><0.0001 in either of two breast cancer GWAS in the UK (UK2 and BBCS) <sup><xref ref-type="bibr" rid="R17">17</xref>, <xref ref-type="bibr" rid="R18">18</xref></sup>. We attempted to genotype these SNPs in up to 41 case-control studies through the Breast Cancer Association Consortium (BCAC). After quality control (QC) exclusions (see Methods), we analysed data on 54,588 cases of invasive breast cancer, 2401 cases of Ductal Carcinoma <italic>in Situ</italic> (DCIS) and 58,098 controls. In addition, we utilised data from 7 additional breast cancer GWAS from which summary results had been obtained based on imputation to Hapmap 2 CEU. Results from the GWAS and BCAC replication were then combined to derive the overall evidence of association for each SNP based on 69,564 cases and 68,150 controls.</p><p id="P4">Three SNPs showed strong evidence for association in European women, consistent with the effect seen in the original GWAS (<xref ref-type="table" rid="T1">Table 1</xref> and <xref ref-type="fig" rid="F1">Figure 1</xref>). In each case, the genotype-specific odds ratios (ORs) were consistent with an allele dose (log-additive) model (<xref ref-type="supplementary-material" rid="SD1">Supplementary Table 1</xref>). SNP rs2823093 showed some evidence of heterogeneity in the per-allele ORs among studies in the replication stage (<italic>P</italic>=0.002), with particularly marked associations in two studies (HMBCS, RBCS; <xref ref-type="fig" rid="F1">Figure 1</xref>). The association in the replication stage remained highly significant, however, even after excluding these two studies (<italic>P</italic>=7.1×10<sup>−7</sup>). The other two loci showed no evidence of heterogeneity among studies. Two additional SNPs on 17q21, rs2532348 and rs199523 (correlated at r<sup>2</sup>=0.80 in the UK2 GWAS), gave more limited evidence of replication (<italic>P</italic>=0.000078 and <italic>P</italic>=0.0063) and reached <italic>P</italic>=5.8×10<sup>−7</sup> and <italic>P</italic>=2.6×10<sup>−6</sup> respectively when combined with the GWAS data (<xref ref-type="supplementary-material" rid="SD1">Supplementary Table 2</xref>). These SNPs were only genotyped in the UK2 GWAS. They could not be imputed using HapMap, and were only successfully genotyped in 12 studies in the BCAC replication. Moreover, for SNP rs2532348 there was evidence of heterogeneity among studies in the per-allele ORs in BCAC (<italic>P</italic>=0.001). Further data will be required to determine whether this SNP is associated with breast cancer risk. Three other SNPs (rs10940235 on 5q11, rs4403040 on 4q21 and rs6027564 on 20q13) showed evidence of replication at P<0.01 but none reached genome-wide levels of statistical significance (<xref ref-type="supplementary-material" rid="SD1">Supplementary Table 2</xref>).</p><p id="P5">For women of Asian ancestry, SNP rs10771399 (12p11) was also associated with breast cancer risk, with the estimated OR being similar to that in women of European ancestry (<xref ref-type="supplementary-material" rid="SD1">Supplementary Table 3</xref>). There was no significant evidence of association for either SNPs rs1292011 (12q24) or rs2823093 (21q21) in women of Asian ancestry. For rs2823093, the estimated OR was in the opposite direction than that in women of European ancestry, but the estimates did not differ significantly (<xref ref-type="supplementary-material" rid="SD1">Supplementary Table 3</xref>).</p><p id="P6">SNP rs10771399 showed strong evidence of association with both estrogen receptor (ER)-positive and ER-negative breast cancer, with the estimated per-allele ORs being similar (based on 24,775 ER-positive and 7,122 ER-negative cases; <xref ref-type="supplementary-material" rid="SD1">Supplementary Table 4a</xref>). In contrast, for SNPs rs1292011 and rs2823093, the association was confined to ER-positive breast cancer, with no evidence of association for ER-negative disease (<xref ref-type="supplementary-material" rid="SD1">Supplementary Table 4a</xref>). These latter results conform to the general pattern of a preponderance of common susceptibility loci for ER-positive disease identified through GWAS based on cases unselected for disease subtype <sup><xref ref-type="bibr" rid="R19">19</xref>, <xref ref-type="bibr" rid="R20">20</xref></sup>. In terms of per-allele OR, SNP rs10771399 has one of the strongest effects identified to date for ER-negative breast cancer (OR 0.85, 95%CI 0.80-0.90). For all three SNPs, the per-allele OR for DCIS was similar to that for invasive disease (based on up to 2,148 DCIS cases; <xref ref-type="supplementary-material" rid="SD1">Supplementary Table 4b</xref>). For SNP rs10771399, the estimated OR was higher for 10 studies in which cases were selected for a positive family history and/or bilaterality, as would be expected under a polygenic model <sup><xref ref-type="bibr" rid="R21">21</xref></sup> (<italic>P</italic>=0.027, <xref ref-type="supplementary-material" rid="SD1">Supplementary Table 5</xref>); however, exclusion of data from these studies made little difference to the estimated OR. There was no evidence for difference in the per-allele OR by age at diagnosis for any SNP (<xref ref-type="supplementary-material" rid="SD1">Supplementary Table 4c</xref>).</p><p id="P7">SNP rs10771399 lies in a ~300kb linkage disequilibrium (LD) block on 12p11 that contains one known gene, <italic>PTHLH</italic> (Parathyroid Hormone like Hormone isoform 1), also called <italic>PTHrP</italic> (Parathyroid hormone–related protein; <xref ref-type="fig" rid="F2">Figure 2a</xref>). PTHrP is expressed in a wide variety of tissues and in many malignancies, including 60% of breast tumors and is required for normal mammary gland and bone development <sup><xref ref-type="bibr" rid="R22">22</xref>-<xref ref-type="bibr" rid="R25">25</xref></sup>. During lactation it is released by the mammary gland to regulate the transfer of calcium from the skeleton to the milk <sup><xref ref-type="bibr" rid="R26">26</xref>, <xref ref-type="bibr" rid="R27">27</xref></sup>. Tumor secreted PTHrP mimics the action of parathyroid hormone (PTH) by binding to its receptor PTH1R <sup><xref ref-type="bibr" rid="R28">28</xref></sup> promoting humoral hypercalcemia as well as metastasis of breast cancer cells to the bone <sup><xref ref-type="bibr" rid="R23">23</xref>, <xref ref-type="bibr" rid="R29">29</xref>-<xref ref-type="bibr" rid="R31">31</xref></sup>. It has been suggested that PTHrP enhances tumorigenesis through its pro-proliferative and anti-apoptotic activity by promoting survival in cells subjected to apoptosis <sup><xref ref-type="bibr" rid="R32">32</xref>, <xref ref-type="bibr" rid="R33">33</xref></sup>. However, conflicting data regarding the correlation of PTHrP expression level and breast cancer survival have been found <sup><xref ref-type="bibr" rid="R24">24</xref>, <xref ref-type="bibr" rid="R34">34</xref>-<xref ref-type="bibr" rid="R36">36</xref></sup>. Moreover, a recent study reported that loss of PTHrP accelerates tumor incidence in DCIS and is associated with monocyte infiltration <sup><xref ref-type="bibr" rid="R37">37</xref></sup>.</p><p id="P8">SNP rs1292011 on 12q24 lies in a ~ 100 kb LD block that contains no known genes (<xref ref-type="fig" rid="F2">Figure 2b</xref>). SNPs in this region have been found to be associated with squamous esophageal carcinoma, renal cell carcinoma, liver adenoma, heart disease and type 1 diabetes as well as blood pressure and PSA levels <sup><xref ref-type="bibr" rid="R38">38</xref>-<xref ref-type="bibr" rid="R47">47</xref></sup>. Two plausible cancer candidate genes, <italic>MAPKAPK5</italic> (mitogen-activated protein kinase-activated protein kinase 5, also called <italic>MK5/PRAK</italic>) and <italic>TBX3</italic> (T-box3), lie within 2 Mb of rs1292011. MAPKAPK5 is a member of the serine/threonine kinase family and is directly activated by <italic>Myc</italic><sup><xref ref-type="bibr" rid="R48">48</xref></sup>. TBX3 plays a role in mammary gland development<sup><xref ref-type="bibr" rid="R49">49</xref></sup> and its haplo-insufficiency is associated with Ulnar-Mammary disorder<sup><xref ref-type="bibr" rid="R50">50</xref></sup>. <italic>TBX3</italic> was found to be amplified and over-expressed in several cancers including breast cancer <sup><xref ref-type="bibr" rid="R51">51</xref>-<xref ref-type="bibr" rid="R54">54</xref></sup> and at high levels in plasma from breast and ovarian cancer patients <sup><xref ref-type="bibr" rid="R52">52</xref></sup>. Recently, it has been shown that estrogen regulates the expansion of breast cancer stem cells through the FGF/FGFR/TBX3 pathway <sup><xref ref-type="bibr" rid="R52">52</xref>, <xref ref-type="bibr" rid="R55">55</xref></sup> and that <italic>TBX3</italic> is a direct downstream target of the Wnt/beta-catenin pathway <sup><xref ref-type="bibr" rid="R56">56</xref></sup>. The expression of <italic>TBX3</italic> was found to be significantly higher (P<0.0001) in ER-positive than in ER-negative breast cancer tumors in two independent datasets containing 781 tumors (with HGU-133A Affymetrix expression data) <sup><xref ref-type="bibr" rid="R57">57</xref></sup> and 244 tumors (with 44k Agilent expression data) <sup><xref ref-type="bibr" rid="R58">58</xref></sup>. These data suggest that the association of rs1292011 with ER-positive breast cancer could be mediated through its effect on <italic>TBX3</italic>.</p><p id="P9">SNP rs2823093 lies in a ~ 130 Kb LD block containing no known genes. The nearest gene, ~900 Kb downstream, is <italic>NRIP1</italic> (Nuclear Receptor interacting protein 1) (<xref ref-type="fig" rid="F2">Figure 2 c</xref>) or also called <italic>RIP140 (</italic>Receptor-interacting protein 140). RIP140 acts as a strong transcriptional repressor for nuclear receptors <sup><xref ref-type="bibr" rid="R59">59</xref>, <xref ref-type="bibr" rid="R60">60</xref></sup>. It interacts with estrogen receptor α (ERα), represses the ER signalling and inhibits its mitogenic effects <sup><xref ref-type="bibr" rid="R61">61</xref></sup>. This repression is mediated through interaction with FHL1, a protein involved in suppressing cancer cell growth and migration <sup><xref ref-type="bibr" rid="R62">62</xref></sup>. Several lines of evidence suggest that RIP140 plays an important role in the regulation of breast cancer cell growth. Knockdown of <italic>RIP140</italic> was found to induce growth promotion in an ER-positive breast cancer cell line <sup><xref ref-type="bibr" rid="R61">61</xref></sup>. This protein was also highly induced following the treatment of human breast cancer cells with retinoids, known for their breast cancer growth suppression and their anti-estrogenic effects <sup><xref ref-type="bibr" rid="R63">63</xref>-<xref ref-type="bibr" rid="R66">66</xref></sup>. A Spanish case-control study, which genotyped SNPs in 91 breast cancer candidate genes in ~700 cases and ~700 controls, identified a relatively rare SNP at this locus (rs926184 - MAF~2%), located 175 Kb upstream of rs2823093, which showed a modest association with breast cancer <sup><xref ref-type="bibr" rid="R21">67</xref></sup>. These two SNPs are, however, not correlated (r<sup>2</sup>=0 in HapMap CEU). The expression of <italic>NRIP1</italic> has been shown to be significantly higher in ER-positive than ER-negative tumors (p<0.0001) <sup><xref ref-type="bibr" rid="R57">57</xref>, <xref ref-type="bibr" rid="R58">58</xref></sup> suggesting that the association of rs28323093 with ER-positive breast cancer could be mediated through its effect on <italic>NRIP1</italic> expression <sup><xref ref-type="bibr" rid="R57">57</xref>, <xref ref-type="bibr" rid="R58">58</xref></sup>.</p><p id="P10">The three novel susceptibility variants identified in this study are relatively common (MAF 0.11-0.41) and together explain ~0.7% of the familial risk of breast cancer, and bring the total contribution of common low-penetrance breast cancer susceptibility loci to ~9%. The relative risks associated with these variants are modest, with the per-allele ORs for the risk allele ranging from 1.07 to 1.22 fold, but the causal variants underlying some of these loci might confer more substantial risks. The present work highlights the importance of combining GWAS and large-scale replication studies with tumor subtyping in the identification and characterisation of breast cancer susceptibility loci.</p><p id="P11">The genes in these regions (if proven to be the causal genes) underscore that diverse mechanisms are likely to be relevant to breast cancer pathogenesis. Re-sequencing of these loci, combined with fine-scale mapping and functional analyses will provide more insights into the genetic architecture of breast cancer and the pathogenesis of the disease.</p><sec sec-type="methods" id="S1"><title>Methods</title><sec id="S2"><title>GWAS analysis</title><p id="P12">Primary genotype data were obtained for nine breast cancer GWAS in populations of European ancestry (<xref ref-type="supplementary-material" rid="SD1">Supplementary Table 6</xref>). Standard QC was performed on all scans, as follows. We excluded all individuals with low call rate (<95%), extreme high or low heterozygosity (P<10<sup>−5</sup>), and all individuals evaluated to be of non-European ancestry (>15% non-European component, by multidimensional scaling using the three Hapmap2 populations as a reference). We excluded SNPs with: call rate <95%; call rate <99% and MAF<5%, all SNPs with MAF<1%, and SNPs whose genotype frequencies departed from Hardy-Weinberg equilibrium at <italic>P</italic><10<sup>−6</sup> in controls or <italic>P</italic><10<sup>−12</sup> in cases. For highly significant SNPs the genotype intensity cluster plots were examined manually to judge reliability, either centrally or by contacting the original investigators.</p><p id="P13">Data were imputed for all scans for ~2.6M SNPs using HapMap version 2 CEU as a reference, using the program Mach v1.0. Estimated per-allele ORs and standard errors were generated from the imputed genotypes using Probabel<sup><xref ref-type="bibr" rid="R69">69</xref></sup>. For two studies (UK2 and HEBCS), estimates were adjusted by the first three principal components, since this was found to materially reduce the inflation. Residual inflation was then adjusted for by multiplying the variance by a genomic control adjustment factor, based on the ratio of the median chi-squared test statistic to its expected value. BBCS and UK2 used the same control data (WTCCC2) but different genotyping platforms. These studies were imputed separately. For the combined analysis, the control set was divided randomly between the two studies, in proportion to the size of case series, to provide disjoint strata. For a limited subset of SNPs that could not be imputed (including rs2532348 and rs199523 on 17q21), genotype data from the original scan(s) were used in the analysis.</p></sec><sec id="S3"><title>Replication stage</title><p id="P14">SNPs for replication were genotyped in 46 studies, of which 4 were case-only studies that did not contribute to the current analysis (<xref ref-type="supplementary-material" rid="SD1">Supplementary Table 7</xref>). Data from BBCS were excluded as the same cases were included in the GWAS. Seven studies (HABCS, HMBCS, HUBCS, KARBAC, RBCS, SEARCH and SEBCS) were analysed by Fluidigm for 72 SNPs (<xref ref-type="supplementary-material" rid="SD1">Supplementary Table 2</xref>). We selected 63 SNPs selected from UK2: one replaced by a better surrogate, and one failed, so only data were available for 61 SNPs. Ten SNPs were selected from BBCS and one SNP was selected from both scans (The original SNP, rs1975930, also referred to as rs56003999, did not work by Fluidigm and in some iPlex analyses and was replaced by a surrogate rs10771399, r<sup>2</sup>=0.95, which was typed in all studies). Samples from 27 studies were genotyped by iPlex for 29 SNPs that showed the strongest associations. Seven additional studies (ABCFS, CGPS, MCCS, NC-BCFR, OFBCR, PBCS, UKBGS) were genotyped by Taqman for up to 4 SNPs that showed association after the Fluidigm and iPlex genotyping, including all three 3 SNPs discussed in detail here. We restricted the analysis to individuals of European or East Asian ancestry, since the sample size for other ethnicities was too small to give meaningful results.</p><p id="P15">All studies complied with BCAC genotyping QC standards by including at least 2% of samples in duplicate and a common set of 93 CEPH DNAs used by the HapMap Consortium (HAPMAPPT01, Coriell Institute for Medical Research, Cambden, NJ). Genotype data were excluded for: any sample that consistently failed genotyping for >20% of the SNPs typed; all samples on any one plate that had a SNP call rate <90%; all genotype data for any SNP where overall call rate was <95%; and all genotype data for any SNP where duplicate concordance was <98% (based on 2% of samples genotyped in duplicate). In addition, for any SNP for which the <italic>P</italic>-value for departure from Hardy-Weinberg equilibrium for controls was <0.005, clustering of the intensity plots was reviewed manually and the data excluded if clustering was judged to be poor. After QC exclusions we analysed data on 54,588 cases of invasive breast cancer, 2,401 cases of DCIS and 58,098 controls.</p><p id="P16">Per-allele and genotype-specific odds ratios for the replication stage were estimated using logistic regression, adjusted for study. Women of European and Asian ancestry were analysed separately. NC-BCFR contributed cases and controls to both European and Asian analyses; for the remaining studies the subjects were either predominantly European or predominantly Asian, and subjects from other minority ethnicities were excluded.</p><p id="P17">Statistical significance levels from the GWAS and BCAC replication phases were obtained by combining the logOR estimates and standard errors as in a fixed effect meta-analysis. Heterogeneity in the OR association with each SNP by ER status was evaluated using a case-only analysis, by logistic regression. Heterogeneity by age was evaluated by fitting a linear age × genotype interaction term.</p></sec></sec><sec sec-type="supplementary-material" id="SM"><title>Supplementary Material</title><supplementary-material content-type="local-data" id="SD1"><label>1</label><media xlink:href="NIHMS40160-supplement-1.pdf" orientation="portrait" xlink:type="simple" id="d36e2576" position="anchor" mimetype="application" mime-subtype="pdf"></media></supplementary-material></sec></body><back><ack id="S4"><title>Acknowledgements</title><p>We would thank the following individuals for their contribution to this project (study in brackets): Sten Cornelissen, Richard van Hien, Linde Braaf , Laura Van’t Veer, Bas Bueno-de-Mesquita and Sander Canisius (ABCS); Niall McInerney, Gabrielle Colleran, Andrew Rowan and Nicola Miller (BIGGS); Anne Langheinz (BSUCH) ; José Ignacio Arias Pérez, Pilar Zamora, Primitiva Menendez, Tais Moreno and Guillermo Pita (CNIO-BCS); Muriel Adank, Margreet Ausems and Senno Verhoef (DFBBCS); Ute Hamann, Yon-Dschun Ko, Christian Baisch, Hans-Peter Fischer, Beate Pesch, Sylvia Rabstein and Volker Harth (GENICA); Kirsimari Aaltonen, Päivi Heikkilä, Tuomas Heikkinen, Dario Greco, RN Hanna Jäntti and Irja Erkkilä (HEBCS); Helena Kemiläinen, Eija Myöhänen and Aija Parkkinen (KBCP); Tracy Slanger, Elke Mutschelknauss, S. Behrens, R. Birr, M.Celik, U. Eilber, B. Kaspereit, N. Knese and K. Smit (MARIE); Paolo Radice, Bernard Peissel, Monica Barile, Marco A. Pierotti (MBCSG); Teresa Selander, Mona Gill, Lucine Collins and Nayana Weerasooriya (OFBCR); Mervi Grip, Kari Mononen and Meeri Otsukka (OBCS); E. Krol-Warmerdam, and J. Blom (ORIGO); Dr. Prat Boonyawongviroj and Dr. Pornthep Siriwanarungsan (ACP). For full acknowledgements including funding see <xref ref-type="supplementary-material" rid="SD1">Supplementary Note</xref>.</p></ack><fn-group><fn id="FN1"><p id="P18"><bold>URLs</bold> HapMap <ext-link ext-link-type="uri" xlink:href="http://hapmap.ncbi.nlm.nih.gov/">http://hapmap.ncbi.nlm.nih.gov/</ext-link></p></fn><fn id="FN2"><p id="P19"><bold>Conflicts of interest</bold> The authors have no conflict competing financial interests to disclose.</p></fn><fn id="FN3"><p id="P20"><bold>Authors contribution</bold> M.G. and D.F.E. wrote the manuscript. K.M., M.G. and D.F.E. performed the statistical analysis. O.F., N.J., N.O., I.dosS.S., M.L. and J.P. led the BBCS GWAS. D.F.E., P.D.P.P., A.M.D., C.T. and N.R. led the UK2 GWAS. Q.Waisfisz and H.M.-H. led the DFBBCS GWAS, with support from A.G.U. and F.R.. P.Hall, K.C., A.I. and J.Liu led the SASBAC GWAS. H.N., K.A. and C.Blomqvist led the HEBCS GWAS. AMeindl, R.K.S. and B.M.-M. led the GC-HBOC GWAS. J.C.-C., R.H., S.N. and D.F.-J. led the MARIE GWAS. J.L.H., M.Southey, H.T., E.M., D.S. and M.Bui led the ABCFS/kConFab GWAS. D.J.H. and S.J.C. led the CGEMS GWAS. E.D. and J.D. provided bioinformatics support. Q.Wang, M.K.H. and K.D. provided data management support for BCAC. C.Baynes, D.C., M.M. and S.A. managed centralised genotyping for BCAC samples. M.K.S. provided gene expression analysis. J.L.H., M.Southey, C.A. and D.J.P. co-ordinated the ABCFR study. M.K.S., A.B., S.V. and F.B.L.H. co-ordinated ABCS. P.A.F. co-ordinated the BBCC study. E.S., I.T. and M.K. co-ordinated BIGGS. F.Marme, ASchneeweiss, C.Sohn and B.Burwinkel co-ordinated the BSUCH study. P.G., T.T., E.C.-D. and F.Menegaux co-ordinated the CECILE study. S.E.B., B.G.M. and S.F.N. co-ordinated CGPS. R.L.M., R.A., A.G.-N. and J.Benítez co-ordinated CNIO-BCS. H.A.-C., A.Z., L.Bernstein and C.C.D. co-ordinated CTS. H.Brenner, H.M., V.A. and C.Stegmaier co-ordinated the ESTHER study. C.J., H.Brauch and B.P. co-ordinated the GENICA study. J.C.-C., S.W.-G. and U.E. co-ordinated the GESBC study. T.D., P.S., M.Bremer and P.Hillemanns co-ordinated HABCS. N.V.B., N.N.A., Y.I.R., J.H.K. and T.D. co-ordinated HMBCS. M.Bermisheva, D.P., N.V.B., T.D., and E.K. co-ordinated HUBCS. A.Lindblom and S.Margolin co-ordinated the KARBAC study. A.Mannermaa, V.Kataja, V.-M.K. and J.M.H. co-ordinated the KBCP study. D.L., B.T.Y., G.F. and K.L. co-ordinated the LMBC study. S.Manoukian, B.Bonanni, S.F. and P.P. co-ordinated the MBCSG study. F.J.C., X.W., K.S. and A.Lee co-ordinated the MCBCS study. M.Southey, G.G.G., L.Baglietto, G.S. and C.M. co-ordinated MCCS. G.G.A., V.Kristensen and A.-L.B.-D. co-ordinated NBCS. E.M.J. and A.Miron co-ordinated the NC-BCFR study. R.W., K.P., A.J.-V. and S.K. co-ordinated OBCS. I.L.A., G.G. and A.M.M. co-ordinated the OFBCR study. P.D. C.J.vanA., R.A.E.M.T. and C.Seynaeve co-ordinated the ORIGO study. J.D.F., M.G.-C., L.Brinton and J.Lissowska co-ordinated PBCS. M.J.H., A.H., R.A.O. and A.M.W.v.d.O. co-ordinated RBCS. A.Cox and M.W.R.R. co-ordinated SBCS. B.A.P. initiated SEARCH with P.D.P.P. and D.F.E.. M.Shah co-ordinated SEARCH. A.J., J.Lubinski, K.J. and K.Durda co-ordinated SZBCS. M.J., M.Schoemaker, A.A. and A.Swerdlow co-ordinated UKBGS. G.C.-T. led the contribution of kConFab cases and AOCS controls to BCAC, J.Beesley and X.C. performed iPLEX genotyping for several of the BCAC sites. K.R.M., A.Lophatananon, S.R. and A.Chaiwerawattana co-ordinated the ACP study. D.K., K.-Y.Y. and D.-Y.N. co-ordinated SEBCS. C.-Y.S. 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Squares represent the estimated per-allele odds ratio (OR) for individual studies. The area of square is inversely proportional to the precise of the estimate. Diamonds represent the summary OR estimates for the subgroups indicated. Horizontal lines represent 95% confidence limits.</p></caption><graphic xlink:href="emss-40160-f0001"></graphic></fig><fig id="F2" orientation="portrait" position="float"><label>Figures 2a, b and c</label><caption><p>Association plots for the three new breast cancer susceptibility loci at (a) 12p11 (b) 12q24 and (c) 21q21 drawn using the SNAP software35 <sup><xref ref-type="bibr" rid="R68">68</xref></sup>. Genotyped and imputed SNPs are plotted based on their chromosomal position in build 36 on the X axis and their overall <italic>P</italic> values (as −log10 values) from the UK2 and BBCS GWAS on the Y axis. For each region, the most strongly associated SNP is represented by a diamond. The intensity of the red shading reflects the strength of correlation (r<sup>2</sup>) between the best SNP and the other SNPs in the region. Genes present in the region (if any) are indicated in green.</p></caption><graphic xlink:href="emss-40160-f0002"></graphic><graphic xlink:href="emss-40160-f0003"></graphic><graphic xlink:href="emss-40160-f0004"></graphic></fig><table-wrap id="T1" position="float" orientation="portrait"><label>Table 1</label><table frame="box" rules="all"><thead><tr><th align="left" valign="top" rowspan="1" colspan="1">SNP</th><th align="left" valign="top" rowspan="1" colspan="1">Chromosome<break></break>Position<xref ref-type="table-fn" rid="TFN1">1</xref></th><th align="left" valign="top" rowspan="1" colspan="1">Alleles<xref ref-type="table-fn" rid="TFN2">2</xref></th><th align="left" valign="top" rowspan="1" colspan="1">MAF</th><th align="left" valign="top" rowspan="1" colspan="1">Stage</th><th align="left" valign="top" rowspan="1" colspan="1">Per-allele<break></break>OR<break></break>(95%CI)<xref ref-type="table-fn" rid="TFN3">3</xref></th><th align="left" valign="top" rowspan="1" colspan="1">P</th><th align="left" valign="top" rowspan="1" colspan="1">Combined P</th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">rs10771399</td><td align="left" valign="top" rowspan="1" colspan="1">12p11<break></break>28046347</td><td align="left" valign="top" rowspan="1" colspan="1">AG</td><td align="left" valign="top" rowspan="1" colspan="1">0.12</td><td align="left" valign="top" rowspan="1" colspan="1">UK2</td><td align="left" valign="top" rowspan="1" colspan="1">0.79<break></break>(0.71-0.87)</td><td align="left" valign="top" rowspan="1" colspan="1">3.1×10<sup>−6</sup></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">0.11</td><td align="left" valign="top" rowspan="1" colspan="1">BBCS</td><td align="left" valign="top" rowspan="1" colspan="1">0.84<break></break>(0.74-0.96)</td><td align="left" valign="top" rowspan="1" colspan="1">.008</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">0.10</td><td align="left" valign="top" rowspan="1" colspan="1">Other GWAS</td><td align="left" valign="top" rowspan="1" colspan="1">0.83<break></break>(0.75-0.91)</td><td align="left" valign="top" rowspan="1" colspan="1">5.7×10<sup>−5</sup></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">0.12</td><td align="left" valign="top" rowspan="1" colspan="1">BCAC<break></break>replication</td><td align="left" valign="top" rowspan="1" colspan="1">0.85<break></break>(0.83-0.88)</td><td align="left" valign="top" rowspan="1" colspan="1">3.3×10<sup>−27</sup></td><td align="left" valign="top" rowspan="1" colspan="1">2.7×10<sup>−35</sup></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs1292011</td><td align="left" valign="top" rowspan="1" colspan="1">12q24<break></break>114320905</td><td align="left" valign="top" rowspan="1" colspan="1">AG</td><td align="left" valign="top" rowspan="1" colspan="1">0.41</td><td align="left" valign="top" rowspan="1" colspan="1">UK2</td><td align="left" valign="top" rowspan="1" colspan="1">0.88<break></break>(0.83-0.94)</td><td align="left" valign="top" rowspan="1" colspan="1">5.8×10<sup>−5</sup></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">0.42</td><td align="left" valign="top" rowspan="1" colspan="1">BBCS</td><td align="left" valign="top" rowspan="1" colspan="1">0.95<break></break>(0.88-1.03)</td><td align="left" valign="top" rowspan="1" colspan="1">0.23</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">0.40</td><td align="left" valign="top" rowspan="1" colspan="1">Other GWAS</td><td align="left" valign="top" rowspan="1" colspan="1">0.91<break></break>(0.86-0.96)</td><td align="left" valign="top" rowspan="1" colspan="1">.0008</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">0.41</td><td align="left" valign="top" rowspan="1" colspan="1">BCAC<break></break>replication</td><td align="left" valign="top" rowspan="1" colspan="1">0.92<break></break>(0.91-0.94)</td><td align="left" valign="top" rowspan="1" colspan="1">6.2×10<sup>−14</sup></td><td align="left" valign="top" rowspan="1" colspan="1">4.3×10<sup>−19</sup></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs2823093</td><td align="left" valign="top" rowspan="1" colspan="1">21q21<break></break>15442703</td><td align="left" valign="top" rowspan="1" colspan="1">GA</td><td align="left" valign="top" rowspan="1" colspan="1">0.26</td><td align="left" valign="top" rowspan="1" colspan="1">UK2</td><td align="left" valign="top" rowspan="1" colspan="1">0.96<break></break>(0.89-1.03)</td><td align="left" valign="top" rowspan="1" colspan="1">0.21</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">0.26</td><td align="left" valign="top" rowspan="1" colspan="1">BBCS</td><td align="left" valign="top" rowspan="1" colspan="1">0.88<break></break>(0.76-0.92)</td><td align="left" valign="top" rowspan="1" colspan="1">.00013</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">0.26</td><td align="left" valign="top" rowspan="1" colspan="1">Other GWAS</td><td align="left" valign="top" rowspan="1" colspan="1">0.91<break></break>(0.85-0.97)</td><td align="left" valign="top" rowspan="1" colspan="1">.0032</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">0.27</td><td align="left" valign="top" rowspan="1" colspan="1">BCAC<break></break>replication</td><td align="left" valign="top" rowspan="1" colspan="1">0.94<break></break>(0.92-0.96)</td><td align="left" valign="top" rowspan="1" colspan="1">1.7×10<sup>−9</sup></td><td align="left" valign="top" rowspan="1" colspan="1">1.1×10<sup>−12</sup></td></tr></tbody></table><table-wrap-foot><fn id="TFN1"><label>1</label><p id="P21">Build 36</p></fn><fn id="TFN2"><label>2</label><p id="P22">Minor allele listed second</p></fn><fn id="TFN3"><label>3</label><p id="P23">Per copy of the minor allele</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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