Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index
Identifieur interne : 002E04 ( Pmc/Corpus ); précédent : 002E03; suivant : 002E05Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index
Auteurs : Elizabeth K. Speliotes ; Cristen J. Willer ; Sonja I. Berndt ; Keri L. Monda ; Gudmar Thorleifsson ; Anne U. Jackson ; Hana Lango Allen ; Cecilia M. Lindgren ; Jian N Luan ; Reedik M Gi ; Joshua C. Randall ; Sailaja Vedantam ; Thomas W. Winkler ; Lu Qi ; Tsegaselassie Workalemahu ; Iris M. Heid ; Valgerdur Steinthorsdottir ; Heather M. Stringham ; Michael N. Weedon ; Eleanor Wheeler ; Andrew R. Wood ; Teresa Ferreira ; Robert J. Weyant ; Ayellet V. Segré ; Karol Estrada ; Liming Liang ; James Nemesh ; Ju-Hyun Park ; Stefan Gustafsson ; Tuomas O. Kilpel Inen ; Jian Yang ; Nabila Bouatia-Naji ; T Nu Esko ; Mary F. Feitosa ; Zoltán Kutalik ; Massimo Mangino ; Soumya Raychaudhuri ; Andre Scherag ; Albert Vernon Smith ; Ryan Welch ; Jing Hua Zhao ; Katja K. Aben ; Devin M. Absher ; Najaf Amin ; Anna L. Dixon ; Eva Fisher ; Nicole L. Glazer ; Michael E. Goddard ; Nancy L. Heard-Costa ; Volker Hoesel ; Jouke-Jan Hottenga ; Sa Johansson ; Toby Johnson ; Shamika Ketkar ; Claudia Lamina ; Shengxu Li ; Miriam F. Moffatt ; Richard H. Myers ; Narisu Narisu ; John R. B. Perry ; Marjolein J. Peters ; Michael Preuss ; Samuli Ripatti ; Fernando Rivadeneira ; Camilla Sandholt ; Laura J. Scott ; Nicholas J. Timpson ; Jonathan P. Tyrer ; Sophie Van Wingerden ; Richard M. Watanabe ; Charles C. White ; Fredrik Wiklund ; Christina Barlassina ; Daniel I. Chasman ; Matthew N. Cooper ; John-Olov Jansson ; Robert W. Lawrence ; Niina Pellikka ; Inga Prokopenko ; Jianxin Shi ; Elisabeth Thiering ; Helene Alavere ; Maria T. S. Alibrandi ; Peter Almgren ; Alice M. Arnold ; Thor Aspelund ; Larry D. Atwood ; Beverley Balkau ; Anthony J. Balmforth ; Amanda J. Bennett ; Yoav Ben-Shlomo ; Richard N. Bergman ; Sven Bergmann ; Heike Biebermann ; Alexandra I. F. Blakemore ; Tanja Boes ; Lori L. Bonnycastle ; Stefan R. Bornstein ; Morris J. Brown ; Thomas A. Buchanan ; Fabio Busonero ; Harry Campbell ; Francesco P. Cappuccio ; Christine Cavalcanti-Proença ; Yii-Der Ida Chen ; Chih-Mei Chen ; Peter S. Chines ; Robert Clarke ; Lachlan Coin ; John Connell ; Ian N. M. Day ; Martin Den Heijer ; Jubao Duan ; Shah Ebrahim ; Paul Elliott ; Roberto Elosua ; Gudny Eiriksdottir ; Michael R. Erdos ; Johan G. Eriksson ; Maurizio F. Facheris ; Stephan B. Felix ; Pamela Fischer-Posovszky ; Aaron R. Folsom ; Nele Friedrich ; Nelson B. Freimer ; Mao Fu ; Stefan Gaget ; Pablo V. Gejman ; Eco J. C. Geus ; Christian Gieger ; Anette P. Gjesing ; Anuj Goel ; Philippe Goyette ; Harald Grallert ; Jürgen Gr Ler ; Danielle M. Greenawalt ; Christopher J. Groves ; Vilmundur Gudnason ; Candace Guiducci ; Anna-Liisa Hartikainen ; Neelam Hassanali ; Alistair S. Hall ; Aki S. Havulinna ; Caroline Hayward ; Andrew C. Heath ; Christian Hengstenberg ; Andrew A. Hicks ; Anke Hinney ; Albert Hofman ; Georg Homuth ; Jennie Hui ; Wilmar Igl ; Carlos Iribarren ; Bo Isomaa ; Kevin B. Jacobs ; Ivonne Jarick ; Elizabeth Jewell ; Ulrich John ; Torben J Rgensen ; Pekka Jousilahti ; Antti Jula ; Marika Kaakinen ; Eero Kajantie ; Lee M. Kaplan ; Sekar Kathiresan ; Johannes Kettunen ; Leena Kinnunen ; Joshua W. Knowles ; Ivana Kolcic ; Inke R. König ; Seppo Koskinen ; Peter Kovacs ; Johanna Kuusisto ; Peter Kraft ; Kirsti Kval Y ; Jaana Laitinen ; Olivier Lantieri ; Chiara Lanzani ; Lenore J. Launer ; Cecile Lecoeur ; Terho Lehtim Ki ; Guillaume Lettre ; Jianjun Liu ; Marja-Liisa Lokki ; Mattias Lorentzon ; Robert N. Luben ; Barbara Ludwig ; Paolo Manunta ; Diana Marek ; Michel Marre ; Nicholas G. Martin ; Wendy L. Mcardle ; Anne Mccarthy ; Barbara Mcknight ; Thomas Meitinger ; Olle Melander ; David Meyre ; Kristian Midthjell ; Grant W. Montgomery ; Mario A. Morken ; Andrew P. Morris ; Rosanda Mulic ; Julius S. Ngwa ; Mari Nelis ; Matt J. Neville ; Dale R. Nyholt ; Christopher J. O Onnell ; Stephen O Ahilly ; Ken K. Ong ; Ben Oostra ; Guillaume Paré ; Alex N. Parker ; Markus Perola ; Irene Pichler ; Kirsi H. Pietil Inen ; Carl G. P. Platou ; Ozren Polasek ; Anneli Pouta ; Suzanne Rafelt ; Olli Raitakari ; Nigel W. Rayner ; Martin Ridderstr Le ; Winfried Rief ; Aimo Ruokonen ; Neil R. Robertson ; Peter Rzehak ; Veikko Salomaa ; Alan R. Sanders ; Manjinder S. Sandhu ; Serena Sanna ; Jouko Saramies ; Markku J. Savolainen ; Susann Scherag ; Sabine Schipf ; Stefan Schreiber ; Heribert Schunkert ; Kaisa Silander ; Juha Sinisalo ; David S. Siscovick ; Jan H. Smit ; Nicole Soranzo ; Ulla Sovio ; Jonathan Stephens ; Ida Surakka ; Amy J. Swift ; Mari-Liis Tammesoo ; Jean-Claude Tardif ; Maris Teder-Laving ; Tanya M. Teslovich ; John R. Thompson ; Brian Thomson ; Anke Tönjes ; Tiinamaija Tuomi ; Joyce B. J. Van Meurs ; Gert-Jan Van Ommen ; Vincent Vatin ; Jorma Viikari ; Sophie Visvikis-Siest ; Veronique Vitart ; Carla I. G. Vogel ; Benjamin F. Voight ; Lindsay L. Waite ; Henri Wallaschofski ; G. Bragi Walters ; Elisabeth Widen ; Susanna Wiegand ; Sarah H. Wild ; Gonneke Willemsen ; Daniel R. Witte ; Jacqueline C. Witteman ; Jianfeng Xu ; Qunyuan Zhang ; Lina Zgaga ; Andreas Ziegler ; Paavo Zitting ; John P. Beilby ; I. Sadaf Farooqi ; Johannes Hebebrand ; Heikki V. Huikuri ; Alan L. James ; Mika K Hönen ; Douglas F. Levinson ; Fabio Macciardi ; Markku S. Nieminen ; Claes Ohlsson ; Lyle J. Palmer ; Paul M. Ridker ; Michael Stumvoll ; Jacques S. Beckmann ; Heiner Boeing ; Eric Boerwinkle ; Dorret I. Boomsma ; Mark J. Caulfield ; Stephen J. Chanock ; Francis S. Collins ; L. Adrienne Cupples ; George Davey Smith ; Jeanette Erdmann ; Philippe Froguel ; Henrik Grönberg ; Ulf Gyllensten ; Per Hall ; Torben Hansen ; Tamara B. Harris ; Andrew T. Hattersley ; Richard B. Hayes ; Joachim Heinrich ; Frank B. Hu ; Kristian Hveem ; Thomas Illig ; Marjo-Riitta Jarvelin ; Jaakko Kaprio ; Fredrik Karpe ; Kay-Tee Khaw ; Lambertus A. Kiemeney ; Heiko Krude ; Markku Laakso ; Debbie A. Lawlor ; Andres Metspalu ; Patricia B. Munroe ; Willem H. Ouwehand ; Oluf Pedersen ; Brenda W. Penninx ; Annette Peters ; Peter P. Pramstaller ; Thomas Quertermous ; Thomas Reinehr ; Aila Rissanen ; Igor Rudan ; Nilesh J. Samani ; Peter E. H. Schwarz ; Alan R. Shuldiner ; Timothy D. Spector ; Jaakko Tuomilehto ; Manuela Uda ; André Uitterlinden ; Timo T. Valle ; Martin Wabitsch ; Gérard Waeber ; Nicholas J. Wareham ; Hugh Watkins ; James F. Wilson ; Alan F. Wright ; M. Carola Zillikens ; Nilanjan Chatterjee ; Steven A. Mccarroll ; Shaun Purcell ; Eric E. Schadt ; Peter M. Visscher ; Themistocles L. Assimes ; Ingrid B. Borecki ; Panos Deloukas ; Caroline S. Fox ; Leif C. Groop ; Talin Haritunians ; David J. Hunter ; Robert C. Kaplan ; Karen L. Mohlke ; Jeffrey R. O Onnell ; Leena Peltonen ; David Schlessinger ; David P. Strachan ; Cornelia M. Van Duijn ; H.-Erich Wichmann ; Timothy M. Frayling ; Unnur Thorsteinsdottir ; Gonçalo R. Abecasis ; Inês Barroso ; Michael Boehnke ; Kari Stefansson ; Kari E. North ; Mark I. Mccarthy ; Joel N. Hirschhorn ; Erik Ingelsson ; Ruth J. F. LoosSource :
- Nature genetics [ 1061-4036 ] ; 2010.
Abstract
Obesity is globally prevalent and highly heritable, but the underlying
genetic factors remain largely elusive. To identify genetic loci for
obesity-susceptibility, we examined associations between body mass index (BMI)
and ~2.8 million SNPs in up to 123,865 individuals, with targeted follow-up of
42 SNPs in up to 125,931 additional individuals. We confirmed 14 known
obesity-susceptibility loci and identified 18 new loci associated with BMI
(
Url:
DOI: 10.1038/ng.686
PubMed: 20935630
PubMed Central: 3014648
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PMC:3014648Le document en format XML
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associated with body mass index</title><author><name sortKey="Speliotes, Elizabeth K" sort="Speliotes, Elizabeth K" uniqKey="Speliotes E" first="Elizabeth K." last="Speliotes">Elizabeth K. Speliotes</name><affiliation><nlm:aff id="A1"> Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation></author><author><name sortKey="Willer, Cristen J" sort="Willer, Cristen J" uniqKey="Willer C" first="Cristen J." last="Willer">Cristen J. Willer</name><affiliation><nlm:aff id="A3"> Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><affiliation><nlm:aff id="A4"> Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Monda, Keri L" sort="Monda, Keri L" uniqKey="Monda K" first="Keri L." last="Monda">Keri L. Monda</name><affiliation><nlm:aff id="A5"> Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, USA</nlm:aff></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation><nlm:aff id="A6"> deCODE Genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Jackson, Anne U" sort="Jackson, Anne U" uniqKey="Jackson A" first="Anne U." last="Jackson">Anne U. Jackson</name><affiliation><nlm:aff id="A3"> Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Allen, Hana Lango" sort="Allen, Hana Lango" uniqKey="Allen H" first="Hana Lango" last="Allen">Hana Lango Allen</name><affiliation><nlm:aff id="A7"> Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, EX1 2LU, UK</nlm:aff></affiliation></author><author><name sortKey="Lindgren, Cecilia M" sort="Lindgren, Cecilia M" uniqKey="Lindgren C" first="Cecilia M." last="Lindgren">Cecilia M. Lindgren</name><affiliation><nlm:aff id="A8"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A9"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Luan, Jian N" sort="Luan, Jian N" uniqKey="Luan J" first="Jian N" last="Luan">Jian N Luan</name><affiliation><nlm:aff id="A10"> MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><affiliation><nlm:aff id="A8"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Randall, Joshua C" sort="Randall, Joshua C" uniqKey="Randall J" first="Joshua C." last="Randall">Joshua C. Randall</name><affiliation><nlm:aff id="A8"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Vedantam, Sailaja" sort="Vedantam, Sailaja" uniqKey="Vedantam S" first="Sailaja" last="Vedantam">Sailaja Vedantam</name><affiliation><nlm:aff id="A1"> Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A11"> Divisions of Genetics and Endocrinology and Program in Genomics, Children’s Hospital, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Winkler, Thomas W" sort="Winkler, Thomas W" uniqKey="Winkler T" first="Thomas W." last="Winkler">Thomas W. Winkler</name><affiliation><nlm:aff id="A12"> Regensburg University Medical Center, Department of Epidemiology and Preventive Medicine, 93053 Regensburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Qi, Lu" sort="Qi, Lu" uniqKey="Qi L" first="Lu" last="Qi">Lu Qi</name><affiliation><nlm:aff id="A13"> Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A14"> Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Workalemahu, Tsegaselassie" sort="Workalemahu, Tsegaselassie" uniqKey="Workalemahu T" first="Tsegaselassie" last="Workalemahu">Tsegaselassie Workalemahu</name><affiliation><nlm:aff id="A13"> Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M." last="Heid">Iris M. Heid</name><affiliation><nlm:aff id="A12"> Regensburg University Medical Center, Department of Epidemiology and Preventive Medicine, 93053 Regensburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A15"> Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Steinthorsdottir, Valgerdur" sort="Steinthorsdottir, Valgerdur" uniqKey="Steinthorsdottir V" first="Valgerdur" last="Steinthorsdottir">Valgerdur Steinthorsdottir</name><affiliation><nlm:aff id="A6"> deCODE Genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Stringham, Heather M" sort="Stringham, Heather M" uniqKey="Stringham H" first="Heather M." last="Stringham">Heather M. Stringham</name><affiliation><nlm:aff id="A3"> Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Weedon, Michael N" sort="Weedon, Michael N" uniqKey="Weedon M" first="Michael N." last="Weedon">Michael N. Weedon</name><affiliation><nlm:aff id="A7"> Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, EX1 2LU, UK</nlm:aff></affiliation></author><author><name sortKey="Wheeler, Eleanor" sort="Wheeler, Eleanor" uniqKey="Wheeler E" first="Eleanor" last="Wheeler">Eleanor Wheeler</name><affiliation><nlm:aff id="A16"> Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Wood, Andrew R" sort="Wood, Andrew R" uniqKey="Wood A" first="Andrew R." last="Wood">Andrew R. Wood</name><affiliation><nlm:aff id="A7"> Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, EX1 2LU, UK</nlm:aff></affiliation></author><author><name sortKey="Ferreira, Teresa" sort="Ferreira, Teresa" uniqKey="Ferreira T" first="Teresa" last="Ferreira">Teresa Ferreira</name><affiliation><nlm:aff id="A8"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Weyant, Robert J" sort="Weyant, Robert J" uniqKey="Weyant R" first="Robert J." last="Weyant">Robert J. Weyant</name><affiliation><nlm:aff id="A3"> Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Segre, Ayellet V" sort="Segre, Ayellet V" uniqKey="Segre A" first="Ayellet V." last="Segré">Ayellet V. Segré</name><affiliation><nlm:aff id="A17"> Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A18"> Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A19"> Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation></author><author><name sortKey="Estrada, Karol" sort="Estrada, Karol" uniqKey="Estrada K" first="Karol" last="Estrada">Karol Estrada</name><affiliation><nlm:aff id="A20"> Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A21"> Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A22"> Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Liang, Liming" sort="Liang, Liming" uniqKey="Liang L" first="Liming" last="Liang">Liming Liang</name><affiliation><nlm:aff id="A23"> Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A24"> Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Nemesh, James" sort="Nemesh, James" uniqKey="Nemesh J" first="James" last="Nemesh">James Nemesh</name><affiliation><nlm:aff id="A18"> Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation></author><author><name sortKey="Park, Ju Hyun" sort="Park, Ju Hyun" uniqKey="Park J" first="Ju-Hyun" last="Park">Ju-Hyun Park</name><affiliation><nlm:aff id="A4"> Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Gustafsson, Stefan" sort="Gustafsson, Stefan" uniqKey="Gustafsson S" first="Stefan" last="Gustafsson">Stefan Gustafsson</name><affiliation><nlm:aff id="A25"> Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kilpel Inen, Tuomas O" sort="Kilpel Inen, Tuomas O" uniqKey="Kilpel Inen T" first="Tuomas O." last="Kilpel Inen">Tuomas O. Kilpel Inen</name><affiliation><nlm:aff id="A10"> MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Yang, Jian" sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name><affiliation><nlm:aff id="A26"> Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Queensland 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name><affiliation><nlm:aff id="A27"> CNRS UMR8199-IBL-Institut Pasteur de Lille, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A28"> University Lille Nord de France, 59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation><nlm:aff id="A29"> Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A30"> Estonian Biocenter, Tartu 51010, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A31"> Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Feitosa, Mary F" sort="Feitosa, Mary F" uniqKey="Feitosa M" first="Mary F." last="Feitosa">Mary F. Feitosa</name><affiliation><nlm:aff id="A32"> Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name><affiliation><nlm:aff id="A33"> Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A34"> Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation><nlm:aff id="A35"> Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Raychaudhuri, Soumya" sort="Raychaudhuri, Soumya" uniqKey="Raychaudhuri S" first="Soumya" last="Raychaudhuri">Soumya Raychaudhuri</name><affiliation><nlm:aff id="A18"> Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A36"> Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115 USA</nlm:aff></affiliation></author><author><name sortKey="Scherag, Andre" sort="Scherag, Andre" uniqKey="Scherag A" first="Andre" last="Scherag">Andre Scherag</name><affiliation><nlm:aff id="A37"> Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, 45122 Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name><affiliation><nlm:aff id="A38"> Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A39"> University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Welch, Ryan" sort="Welch, Ryan" uniqKey="Welch R" first="Ryan" last="Welch">Ryan Welch</name><affiliation><nlm:aff id="A3"> Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="A10"> MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Aben, Katja K" sort="Aben, Katja K" uniqKey="Aben K" first="Katja K." last="Aben">Katja K. Aben</name><affiliation><nlm:aff id="A40"> Comprehensive Cancer Center East, 6501 BG Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Absher, Devin M" sort="Absher, Devin M" uniqKey="Absher D" first="Devin M." last="Absher">Devin M. Absher</name><affiliation><nlm:aff id="A41"> Hudson Alpha Institute for Biotechnology, Huntsville, Alabama 35806, USA</nlm:aff></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation><nlm:aff id="A20"> Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Dixon, Anna L" sort="Dixon, Anna L" uniqKey="Dixon A" first="Anna L." last="Dixon">Anna L. Dixon</name><affiliation><nlm:aff id="A42"> Department of Pharmacy and Pharmacology, University of Bath, Bath, BA1 1RL, UK</nlm:aff></affiliation></author><author><name sortKey="Fisher, Eva" sort="Fisher, Eva" uniqKey="Fisher E" first="Eva" last="Fisher">Eva Fisher</name><affiliation><nlm:aff id="A43"> Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany</nlm:aff></affiliation></author><author><name sortKey="Glazer, Nicole L" sort="Glazer, Nicole L" uniqKey="Glazer N" first="Nicole L." last="Glazer">Nicole L. Glazer</name><affiliation><nlm:aff id="A44"> Department of Medicine, University of Washington, Seattle, Washington 98101, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A45"> Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA</nlm:aff></affiliation></author><author><name sortKey="Goddard, Michael E" sort="Goddard, Michael E" uniqKey="Goddard M" first="Michael E." last="Goddard">Michael E. Goddard</name><affiliation><nlm:aff id="A46"> University of Melbourne, Parkville 3010, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A47"> Department of Primary Industries, Melbourne, Victoria 3001, Australia</nlm:aff></affiliation></author><author><name sortKey="Heard Costa, Nancy L" sort="Heard Costa, Nancy L" uniqKey="Heard Costa N" first="Nancy L." last="Heard-Costa">Nancy L. Heard-Costa</name><affiliation><nlm:aff id="A48"> Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Hoesel, Volker" sort="Hoesel, Volker" uniqKey="Hoesel V" first="Volker" last="Hoesel">Volker Hoesel</name><affiliation><nlm:aff id="A49"> Technical University Munich, Chair of Biomathematics, Boltzmannstrasse 3, 85748 Garching</nlm:aff></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation><nlm:aff id="A50"> Department of Biological Psychology, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation><nlm:aff id="A51"> Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, SE-75185 Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A52"> Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, N-7489, Norway</nlm:aff></affiliation></author><author><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name><affiliation><nlm:aff id="A33"> Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A34"> Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A53"> Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A54"> Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK</nlm:aff></affiliation></author><author><name sortKey="Ketkar, Shamika" sort="Ketkar, Shamika" uniqKey="Ketkar S" first="Shamika" last="Ketkar">Shamika Ketkar</name><affiliation><nlm:aff id="A32"> Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Lamina, Claudia" sort="Lamina, Claudia" uniqKey="Lamina C" first="Claudia" last="Lamina">Claudia Lamina</name><affiliation><nlm:aff id="A15"> Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A55"> Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria</nlm:aff></affiliation></author><author><name sortKey="Li, Shengxu" sort="Li, Shengxu" uniqKey="Li S" first="Shengxu" last="Li">Shengxu Li</name><affiliation><nlm:aff id="A10"> MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Moffatt, Miriam F" sort="Moffatt, Miriam F" uniqKey="Moffatt M" first="Miriam F." last="Moffatt">Miriam F. Moffatt</name><affiliation><nlm:aff id="A56"> National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK</nlm:aff></affiliation></author><author><name sortKey="Myers, Richard H" sort="Myers, Richard H" uniqKey="Myers R" first="Richard H." last="Myers">Richard H. Myers</name><affiliation><nlm:aff id="A57"> Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Narisu, Narisu" sort="Narisu, Narisu" uniqKey="Narisu N" first="Narisu" last="Narisu">Narisu Narisu</name><affiliation><nlm:aff id="A58"> National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Perry, John R B" sort="Perry, John R B" uniqKey="Perry J" first="John R. B." last="Perry">John R. B. Perry</name><affiliation><nlm:aff id="A7"> Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, EX1 2LU, UK</nlm:aff></affiliation></author><author><name sortKey="Peters, Marjolein J" sort="Peters, Marjolein J" uniqKey="Peters M" first="Marjolein J." last="Peters">Marjolein J. Peters</name><affiliation><nlm:aff id="A21"> Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A22"> Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Preuss, Michael" sort="Preuss, Michael" uniqKey="Preuss M" first="Michael" last="Preuss">Michael Preuss</name><affiliation><nlm:aff id="A59"> Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Universitatsklinikum Schleswig-Holstein, Campus Lubeck, 23562 Lubeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Ripatti, Samuli" sort="Ripatti, Samuli" uniqKey="Ripatti S" first="Samuli" last="Ripatti">Samuli Ripatti</name><affiliation><nlm:aff id="A60"> Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A61"> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="A20"> Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A21"> Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A22"> Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Sandholt, Camilla" sort="Sandholt, Camilla" uniqKey="Sandholt C" first="Camilla" last="Sandholt">Camilla Sandholt</name><affiliation><nlm:aff id="A62"> Hagedorn Research Institute, 2820 Gentofte, Denmark</nlm:aff></affiliation></author><author><name sortKey="Scott, Laura J" sort="Scott, Laura J" uniqKey="Scott L" first="Laura J." last="Scott">Laura J. Scott</name><affiliation><nlm:aff id="A3"> Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J." last="Timpson">Nicholas J. Timpson</name><affiliation><nlm:aff id="A63"> MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, Oakfield House, Bristol, BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Tyrer, Jonathan P" sort="Tyrer, Jonathan P" uniqKey="Tyrer J" first="Jonathan P." last="Tyrer">Jonathan P. Tyrer</name><affiliation><nlm:aff id="A64"> Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Van Wingerden, Sophie" sort="Van Wingerden, Sophie" uniqKey="Van Wingerden S" first="Sophie" last="Van Wingerden">Sophie Van Wingerden</name><affiliation><nlm:aff id="A20"> Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Watanabe, Richard M" sort="Watanabe, Richard M" uniqKey="Watanabe R" first="Richard M." last="Watanabe">Richard M. Watanabe</name><affiliation><nlm:aff id="A65"> Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A66"> Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA</nlm:aff></affiliation></author><author><name sortKey="White, Charles C" sort="White, Charles C" uniqKey="White C" first="Charles C." last="White">Charles C. White</name><affiliation><nlm:aff id="A67"> Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name><affiliation><nlm:aff id="A25"> Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Barlassina, Christina" sort="Barlassina, Christina" uniqKey="Barlassina C" first="Christina" last="Barlassina">Christina Barlassina</name><affiliation><nlm:aff id="A68"> University of Milan, Department of Medicine, Surgery and Dentistry, 20139 Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name><affiliation><nlm:aff id="A69"> Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts 02215, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A70"> Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Cooper, Matthew N" sort="Cooper, Matthew N" uniqKey="Cooper M" first="Matthew N." last="Cooper">Matthew N. Cooper</name><affiliation><nlm:aff id="A71"> Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="Jansson, John Olov" sort="Jansson, John Olov" uniqKey="Jansson J" first="John-Olov" last="Jansson">John-Olov Jansson</name><affiliation><nlm:aff id="A72"> Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lawrence, Robert W" sort="Lawrence, Robert W" uniqKey="Lawrence R" first="Robert W." last="Lawrence">Robert W. Lawrence</name><affiliation><nlm:aff id="A71"> Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="Pellikka, Niina" sort="Pellikka, Niina" uniqKey="Pellikka N" first="Niina" last="Pellikka">Niina Pellikka</name><affiliation><nlm:aff id="A60"> Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A61"> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation><nlm:aff id="A8"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A9"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Shi, Jianxin" sort="Shi, Jianxin" uniqKey="Shi J" first="Jianxin" last="Shi">Jianxin Shi</name><affiliation><nlm:aff id="A4"> Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Thiering, Elisabeth" sort="Thiering, Elisabeth" uniqKey="Thiering E" first="Elisabeth" last="Thiering">Elisabeth Thiering</name><affiliation><nlm:aff id="A15"> Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Alavere, Helene" sort="Alavere, Helene" uniqKey="Alavere H" first="Helene" last="Alavere">Helene Alavere</name><affiliation><nlm:aff id="A29"> Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</nlm:aff></affiliation></author><author><name sortKey="Alibrandi, Maria T S" sort="Alibrandi, Maria T S" uniqKey="Alibrandi M" first="Maria T. S." last="Alibrandi">Maria T. S. Alibrandi</name><affiliation><nlm:aff id="A73"> University Vita-Salute San Raffaele, Division of Nephrology and Dialysis, 20132 Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Almgren, Peter" sort="Almgren, Peter" uniqKey="Almgren P" first="Peter" last="Almgren">Peter Almgren</name><affiliation><nlm:aff id="A74"> Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, 20502 Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Arnold, Alice M" sort="Arnold, Alice M" uniqKey="Arnold A" first="Alice M." last="Arnold">Alice M. Arnold</name><affiliation><nlm:aff id="A75"> Departments of Biostatistics, University of Washington, Seattle, Washington 98195, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A76"> Collaborative Health Studies Coordinating Center, Seattle, Washington 98115, USA</nlm:aff></affiliation></author><author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name><affiliation><nlm:aff id="A38"> Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A39"> University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Atwood, Larry D" sort="Atwood, Larry D" uniqKey="Atwood L" first="Larry D." last="Atwood">Larry D. Atwood</name><affiliation><nlm:aff id="A48"> Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><affiliation><nlm:aff id="A77"> INSERM CESP Centre for Research in Epidemiology and Public Health U1018, Epidemiology of diabetes, obesity and chronic kidney disease over the lifecourse, 94807 Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A78"> University Paris Sud 11, UMRS 1018, 94807 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Balmforth, Anthony J" sort="Balmforth, Anthony J" uniqKey="Balmforth A" first="Anthony J." last="Balmforth">Anthony J. Balmforth</name><affiliation><nlm:aff id="A79"> Multidisciplinary Cardiovascular Research Centre (MCRC), Leeds Institute of Genetics, Health and Therapeutics (LIGHT), University of Leeds, Leeds LS2 9JT, UK</nlm:aff></affiliation></author><author><name sortKey="Bennett, Amanda J" sort="Bennett, Amanda J" uniqKey="Bennett A" first="Amanda J." last="Bennett">Amanda J. Bennett</name><affiliation><nlm:aff id="A9"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name><affiliation><nlm:aff id="A80"> Department of Social Medicine, University of Bristol, Bristol, BS8 2PS, UK</nlm:aff></affiliation></author><author><name sortKey="Bergman, Richard N" sort="Bergman, Richard N" uniqKey="Bergman R" first="Richard N." last="Bergman">Richard N. Bergman</name><affiliation><nlm:aff id="A66"> Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA</nlm:aff></affiliation></author><author><name sortKey="Bergmann, Sven" sort="Bergmann, Sven" uniqKey="Bergmann S" first="Sven" last="Bergmann">Sven Bergmann</name><affiliation><nlm:aff id="A33"> Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A34"> Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Biebermann, Heike" sort="Biebermann, Heike" uniqKey="Biebermann H" first="Heike" last="Biebermann">Heike Biebermann</name><affiliation><nlm:aff id="A81"> Institute of Experimental Paediatric Endocrinology, Charite Universitatsmedizin Berlin, 13353 Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Blakemore, Alexandra I F" sort="Blakemore, Alexandra I F" uniqKey="Blakemore A" first="Alexandra I. F." last="Blakemore">Alexandra I. F. Blakemore</name><affiliation><nlm:aff id="A82"> Department of Genomics of Common Disease, School of Public Health, Imperial College London, W12 0NN, London, UK</nlm:aff></affiliation></author><author><name sortKey="Boes, Tanja" sort="Boes, Tanja" uniqKey="Boes T" first="Tanja" last="Boes">Tanja Boes</name><affiliation><nlm:aff id="A37"> Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, 45122 Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Bonnycastle, Lori L" sort="Bonnycastle, Lori L" uniqKey="Bonnycastle L" first="Lori L." last="Bonnycastle">Lori L. Bonnycastle</name><affiliation><nlm:aff id="A58"> National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Bornstein, Stefan R" sort="Bornstein, Stefan R" uniqKey="Bornstein S" first="Stefan R." last="Bornstein">Stefan R. Bornstein</name><affiliation><nlm:aff id="A83"> Department of Medicine III, University of Dresden, 01307 Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Brown, Morris J" sort="Brown, Morris J" uniqKey="Brown M" first="Morris J." last="Brown">Morris J. Brown</name><affiliation><nlm:aff id="A84"> Clinical Pharmacology Unit, University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Buchanan, Thomas A" sort="Buchanan, Thomas A" uniqKey="Buchanan T" first="Thomas A." last="Buchanan">Thomas A. Buchanan</name><affiliation><nlm:aff id="A66"> Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A85"> Division of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA</nlm:aff></affiliation></author><author><name sortKey="Busonero, Fabio" sort="Busonero, Fabio" uniqKey="Busonero F" first="Fabio" last="Busonero">Fabio Busonero</name><affiliation><nlm:aff id="A86"> Istituto di Neurogenetica e Neurofarmacologia del CNR, Monserrato, 09042, Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="A87"> Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</nlm:aff></affiliation></author><author><name sortKey="Cappuccio, Francesco P" sort="Cappuccio, Francesco P" uniqKey="Cappuccio F" first="Francesco P." last="Cappuccio">Francesco P. Cappuccio</name><affiliation><nlm:aff id="A88"> University of Warwick, Warwick Medical School, Coventry, CV2 2DX, UK</nlm:aff></affiliation></author><author><name sortKey="Cavalcanti Proenca, Christine" sort="Cavalcanti Proenca, Christine" uniqKey="Cavalcanti Proenca C" first="Christine" last="Cavalcanti-Proença">Christine Cavalcanti-Proença</name><affiliation><nlm:aff id="A27"> CNRS UMR8199-IBL-Institut Pasteur de Lille, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A28"> University Lille Nord de France, 59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Chen, Yii Der Ida" sort="Chen, Yii Der Ida" uniqKey="Chen Y" first="Yii-Der Ida" last="Chen">Yii-Der Ida Chen</name><affiliation><nlm:aff id="A89"> Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA</nlm:aff></affiliation></author><author><name sortKey="Chen, Chih Mei" sort="Chen, Chih Mei" uniqKey="Chen C" first="Chih-Mei" last="Chen">Chih-Mei Chen</name><affiliation><nlm:aff id="A15"> Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Chines, Peter S" sort="Chines, Peter S" uniqKey="Chines P" first="Peter S." last="Chines">Peter S. Chines</name><affiliation><nlm:aff id="A58"> National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name><affiliation><nlm:aff id="A90"> Clinical Trial Service Unit, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford, OX3 7LF, UK</nlm:aff></affiliation></author><author><name sortKey="Coin, Lachlan" sort="Coin, Lachlan" uniqKey="Coin L" first="Lachlan" last="Coin">Lachlan Coin</name><affiliation><nlm:aff id="A91"> Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Connell, John" sort="Connell, John" uniqKey="Connell J" first="John" last="Connell">John Connell</name><affiliation><nlm:aff id="A92"> University of Dundee, Ninewells Hospital & Medical School, Dundee, DD1 9SY, UK</nlm:aff></affiliation></author><author><name sortKey="Day, Ian N M" sort="Day, Ian N M" uniqKey="Day I" first="Ian N. M." last="Day">Ian N. M. Day</name><affiliation><nlm:aff id="A63"> MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, Oakfield House, Bristol, BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Den Heijer, Martin" sort="Den Heijer, Martin" uniqKey="Den Heijer M" first="Martin" last="Den Heijer">Martin Den Heijer</name><affiliation><nlm:aff id="A93"> Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A94"> Department of Endocrinology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Duan, Jubao" sort="Duan, Jubao" uniqKey="Duan J" first="Jubao" last="Duan">Jubao Duan</name><affiliation><nlm:aff id="A95"> Northshore University Healthsystem, Evanston, Ilinois 60201, USA</nlm:aff></affiliation></author><author><name sortKey="Ebrahim, Shah" sort="Ebrahim, Shah" uniqKey="Ebrahim S" first="Shah" last="Ebrahim">Shah Ebrahim</name><affiliation><nlm:aff id="A96"> The London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A97"> South Asia Network for Chronic Disease</nlm:aff></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation><nlm:aff id="A91"> Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, W2 1PG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A98"> MRC-HPA Centre for Environment and Health, London W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Elosua, Roberto" sort="Elosua, Roberto" uniqKey="Elosua R" first="Roberto" last="Elosua">Roberto Elosua</name><affiliation><nlm:aff id="A99"> Cardiovascular Epidemiology and Genetics, Institut Municipal D’investigacio Medica and CIBER Epidemiologia y Salud Publica, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation><nlm:aff id="A38"> Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation></author><author><name sortKey="Erdos, Michael R" sort="Erdos, Michael R" uniqKey="Erdos M" first="Michael R." last="Erdos">Michael R. Erdos</name><affiliation><nlm:aff id="A58"> National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G." last="Eriksson">Johan G. Eriksson</name><affiliation><nlm:aff id="A100"> Department of General Practice and Primary health Care, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A101"> National Institute for Health and Welfare, 00271 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A102"> Helsinki University Central Hospital, Unit of General Practice, 00280 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A103"> Folkhalsan Research Centre, 00250 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A104"> Vasa Central Hospital, 65130 Vasa, Finland</nlm:aff></affiliation></author><author><name sortKey="Facheris, Maurizio F" sort="Facheris, Maurizio F" uniqKey="Facheris M" first="Maurizio F." last="Facheris">Maurizio F. Facheris</name><affiliation><nlm:aff id="A105"> Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, 39100, Italy. Affiliated Institute of the University of Lubeck, Lubeck, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A106"> Department of Neurology, General Central Hospital, Bolzano, Italy</nlm:aff></affiliation></author><author><name sortKey="Felix, Stephan B" sort="Felix, Stephan B" uniqKey="Felix S" first="Stephan B." last="Felix">Stephan B. Felix</name><affiliation><nlm:aff id="A107"> Department of Internal Medicine B, Ernst-Moritz-Arndt University, 17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Fischer Posovszky, Pamela" sort="Fischer Posovszky, Pamela" uniqKey="Fischer Posovszky P" first="Pamela" last="Fischer-Posovszky">Pamela Fischer-Posovszky</name><affiliation><nlm:aff id="A108"> Pediatric Endocrinology, Diabetes and Obesity Unit, Department of Pediatrics and Adolescent Medicine, 89075 Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R." last="Folsom">Aaron R. Folsom</name><affiliation><nlm:aff id="A109"> Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis Minnesota 55454, USA</nlm:aff></affiliation></author><author><name sortKey="Friedrich, Nele" sort="Friedrich, Nele" uniqKey="Friedrich N" first="Nele" last="Friedrich">Nele Friedrich</name><affiliation><nlm:aff id="A110"> Institut fur Klinische Chemie und Laboratoriumsmedizin, Universitat Greifswald, 17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Freimer, Nelson B" sort="Freimer, Nelson B" uniqKey="Freimer N" first="Nelson B." last="Freimer">Nelson B. Freimer</name><affiliation><nlm:aff id="A111"> Center for Neurobehavioral Genetics, University of California, Los Angeles, California 90095, USA</nlm:aff></affiliation></author><author><name sortKey="Fu, Mao" sort="Fu, Mao" uniqKey="Fu M" first="Mao" last="Fu">Mao Fu</name><affiliation><nlm:aff id="A112"> Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</nlm:aff></affiliation></author><author><name sortKey="Gaget, Stefan" sort="Gaget, Stefan" uniqKey="Gaget S" first="Stefan" last="Gaget">Stefan Gaget</name><affiliation><nlm:aff id="A27"> CNRS UMR8199-IBL-Institut Pasteur de Lille, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A28"> University Lille Nord de France, 59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Gejman, Pablo V" sort="Gejman, Pablo V" uniqKey="Gejman P" first="Pablo V." last="Gejman">Pablo V. Gejman</name><affiliation><nlm:aff id="A95"> Northshore University Healthsystem, Evanston, Ilinois 60201, USA</nlm:aff></affiliation></author><author><name sortKey="Geus, Eco J C" sort="Geus, Eco J C" uniqKey="Geus E" first="Eco J. C." last="Geus">Eco J. C. Geus</name><affiliation><nlm:aff id="A50"> Department of Biological Psychology, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation><nlm:aff id="A15"> Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Gjesing, Anette P" sort="Gjesing, Anette P" uniqKey="Gjesing A" first="Anette P." last="Gjesing">Anette P. Gjesing</name><affiliation><nlm:aff id="A62"> Hagedorn Research Institute, 2820 Gentofte, Denmark</nlm:aff></affiliation></author><author><name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name><affiliation><nlm:aff id="A8"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A113"> Department of Cardiovascular Medicine, University of Oxford, Level 6 West Wing, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU</nlm:aff></affiliation></author><author><name sortKey="Goyette, Philippe" sort="Goyette, Philippe" uniqKey="Goyette P" first="Philippe" last="Goyette">Philippe Goyette</name><affiliation><nlm:aff id="A114"> Montreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada</nlm:aff></affiliation></author><author><name sortKey="Grallert, Harald" sort="Grallert, Harald" uniqKey="Grallert H" first="Harald" last="Grallert">Harald Grallert</name><affiliation><nlm:aff id="A15"> Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Gr Ler, Jurgen" sort="Gr Ler, Jurgen" uniqKey="Gr Ler J" first="Jürgen" last="Gr Ler">Jürgen Gr Ler</name><affiliation><nlm:aff id="A115"> Department of Medicine III, Pathobiochemistry, University of Dresden, 01307 Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Greenawalt, Danielle M" sort="Greenawalt, Danielle M" uniqKey="Greenawalt D" first="Danielle M." last="Greenawalt">Danielle M. Greenawalt</name><affiliation><nlm:aff id="A116"> Merck Research Laboratories, Merck & Co., Inc., Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Groves, Christopher J" sort="Groves, Christopher J" uniqKey="Groves C" first="Christopher J." last="Groves">Christopher J. Groves</name><affiliation><nlm:aff id="A9"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="A38"> Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A39"> University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Guiducci, Candace" sort="Guiducci, Candace" uniqKey="Guiducci C" first="Candace" last="Guiducci">Candace Guiducci</name><affiliation><nlm:aff id="A1"> Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation><nlm:aff id="A117"> Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Hassanali, Neelam" sort="Hassanali, Neelam" uniqKey="Hassanali N" first="Neelam" last="Hassanali">Neelam Hassanali</name><affiliation><nlm:aff id="A9"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Hall, Alistair S" sort="Hall, Alistair S" uniqKey="Hall A" first="Alistair S." last="Hall">Alistair S. Hall</name><affiliation><nlm:aff id="A79"> Multidisciplinary Cardiovascular Research Centre (MCRC), Leeds Institute of Genetics, Health and Therapeutics (LIGHT), University of Leeds, Leeds LS2 9JT, UK</nlm:aff></affiliation></author><author><name sortKey="Havulinna, Aki S" sort="Havulinna, Aki S" uniqKey="Havulinna A" first="Aki S." last="Havulinna">Aki S. Havulinna</name><affiliation><nlm:aff id="A118"> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="A119"> MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, Scotland, UK</nlm:aff></affiliation></author><author><name sortKey="Heath, Andrew C" sort="Heath, Andrew C" uniqKey="Heath A" first="Andrew C." last="Heath">Andrew C. Heath</name><affiliation><nlm:aff id="A120"> Department of Psychiatry and Midwest Alcoholism Research Center, Washington University School of Medicine, St Louis, Missouri 63108, USA</nlm:aff></affiliation></author><author><name sortKey="Hengstenberg, Christian" sort="Hengstenberg, Christian" uniqKey="Hengstenberg C" first="Christian" last="Hengstenberg">Christian Hengstenberg</name><affiliation><nlm:aff id="A121"> Klinik und Poliklinik fur Innere Medizin II, Universitat Regensburg, 93053 Regensburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A122"> Regensburg University Medical Center, Innere Medizin II, 93053 Regensburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A." last="Hicks">Andrew A. Hicks</name><affiliation><nlm:aff id="A105"> Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, 39100, Italy. Affiliated Institute of the University of Lubeck, Lubeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Hinney, Anke" sort="Hinney, Anke" uniqKey="Hinney A" first="Anke" last="Hinney">Anke Hinney</name><affiliation><nlm:aff id="A123"> Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, 45147 Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A20"> Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A22"> Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name><affiliation><nlm:aff id="A124"> Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, 17487 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Hui, Jennie" sort="Hui, Jennie" uniqKey="Hui J" first="Jennie" last="Hui">Jennie Hui</name><affiliation><nlm:aff id="A71"> Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A125"> PathWest Laboratory of Western Australia, Department of Molecular Genetics, J Block, QEII Medical Centre, Nedlands, Western Australia 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A126"> Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="Igl, Wilmar" sort="Igl, Wilmar" uniqKey="Igl W" first="Wilmar" last="Igl">Wilmar Igl</name><affiliation><nlm:aff id="A51"> Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, SE-75185 Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Iribarren, Carlos" sort="Iribarren, Carlos" uniqKey="Iribarren C" first="Carlos" last="Iribarren">Carlos Iribarren</name><affiliation><nlm:aff id="A127"> Division of Research, Kaiser Permanente Northern California, Oakland, California 94612, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A128"> Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107, USA</nlm:aff></affiliation></author><author><name sortKey="Isomaa, Bo" sort="Isomaa, Bo" uniqKey="Isomaa B" first="Bo" last="Isomaa">Bo Isomaa</name><affiliation><nlm:aff id="A103"> Folkhalsan Research Centre, 00250 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A129"> Department of Social Services and Health Care, 68601 Jakobstad, Finland</nlm:aff></affiliation></author><author><name sortKey="Jacobs, Kevin B" sort="Jacobs, Kevin B" uniqKey="Jacobs K" first="Kevin B." last="Jacobs">Kevin B. Jacobs</name><affiliation><nlm:aff id="A130"> Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA</nlm:aff></affiliation></author><author><name sortKey="Jarick, Ivonne" sort="Jarick, Ivonne" uniqKey="Jarick I" first="Ivonne" last="Jarick">Ivonne Jarick</name><affiliation><nlm:aff id="A131"> Institute of Medical Biometry and Epidemiology, University of Marburg, 35037 Marburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Jewell, Elizabeth" sort="Jewell, Elizabeth" uniqKey="Jewell E" first="Elizabeth" last="Jewell">Elizabeth Jewell</name><affiliation><nlm:aff id="A3"> Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="John, Ulrich" sort="John, Ulrich" uniqKey="John U" first="Ulrich" last="John">Ulrich John</name><affiliation><nlm:aff id="A132"> Institut fur Epidemiologie und Sozialmedizin, Universitat Greifswald, 17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="J Rgensen, Torben" sort="J Rgensen, Torben" uniqKey="J Rgensen T" first="Torben" last="J Rgensen">Torben J Rgensen</name><affiliation><nlm:aff id="A133"> Research Centre for Prevention and Health, Glostrup University Hospital, 2600 Glostrup, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A134"> Faculty of Health Science, University of Copenhagen, 2100 Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Jousilahti, Pekka" sort="Jousilahti, Pekka" uniqKey="Jousilahti P" first="Pekka" last="Jousilahti">Pekka Jousilahti</name><affiliation><nlm:aff id="A118"> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Jula, Antti" sort="Jula, Antti" uniqKey="Jula A" first="Antti" last="Jula">Antti Jula</name><affiliation><nlm:aff id="A135"> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Population Studies Unit, 20720 Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Kaakinen, Marika" sort="Kaakinen, Marika" uniqKey="Kaakinen M" first="Marika" last="Kaakinen">Marika Kaakinen</name><affiliation><nlm:aff id="A136"> Institute of Health Sciences, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A137"> Biocenter Oulu, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Kajantie, Eero" sort="Kajantie, Eero" uniqKey="Kajantie E" first="Eero" last="Kajantie">Eero Kajantie</name><affiliation><nlm:aff id="A101"> National Institute for Health and Welfare, 00271 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A138"> Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, 00029 HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Kaplan, Lee M" sort="Kaplan, Lee M" uniqKey="Kaplan L" first="Lee M." last="Kaplan">Lee M. Kaplan</name><affiliation><nlm:aff id="A2"> Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A70"> Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A139"> MGH Weight Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation></author><author><name sortKey="Kathiresan, Sekar" sort="Kathiresan, Sekar" uniqKey="Kathiresan S" first="Sekar" last="Kathiresan">Sekar Kathiresan</name><affiliation><nlm:aff id="A17"> Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A18"> Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A140"> Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A141"> Framingham Heart Study of the National, Heart, Lung, and Blood Institute and Boston University, Framingham, Massachusetts 01702, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A142"> Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Kettunen, Johannes" sort="Kettunen, Johannes" uniqKey="Kettunen J" first="Johannes" last="Kettunen">Johannes Kettunen</name><affiliation><nlm:aff id="A60"> Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A61"> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kinnunen, Leena" sort="Kinnunen, Leena" uniqKey="Kinnunen L" first="Leena" last="Kinnunen">Leena Kinnunen</name><affiliation><nlm:aff id="A143"> National Institute for Health and Welfare, Diabetes Prevention Unit, 00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Knowles, Joshua W" sort="Knowles, Joshua W" uniqKey="Knowles J" first="Joshua W." last="Knowles">Joshua W. Knowles</name><affiliation><nlm:aff id="A144"> Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA</nlm:aff></affiliation></author><author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name><affiliation><nlm:aff id="A145"> Andrija Stampar School of Public Health, Medical School, University of Zagreb, 10000 Zagreb, Croatia</nlm:aff></affiliation></author><author><name sortKey="Konig, Inke R" sort="Konig, Inke R" uniqKey="Konig I" first="Inke R." last="König">Inke R. König</name><affiliation><nlm:aff id="A59"> Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Universitatsklinikum Schleswig-Holstein, Campus Lubeck, 23562 Lubeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Koskinen, Seppo" sort="Koskinen, Seppo" uniqKey="Koskinen S" first="Seppo" last="Koskinen">Seppo Koskinen</name><affiliation><nlm:aff id="A118"> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kovacs, Peter" sort="Kovacs, Peter" uniqKey="Kovacs P" first="Peter" last="Kovacs">Peter Kovacs</name><affiliation><nlm:aff id="A146"> Interdisciplinary Centre for Clinical Research, University of Leipzig, 04103 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Kuusisto, Johanna" sort="Kuusisto, Johanna" uniqKey="Kuusisto J" first="Johanna" last="Kuusisto">Johanna Kuusisto</name><affiliation><nlm:aff id="A147"> Department of Medicine, University of Kuopio and Kuopio University Hospital, 70210 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="A23"> Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A24"> Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Kval Y, Kirsti" sort="Kval Y, Kirsti" uniqKey="Kval Y K" first="Kirsti" last="Kval Y">Kirsti Kval Y</name><affiliation><nlm:aff id="A148"> HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway</nlm:aff></affiliation></author><author><name sortKey="Laitinen, Jaana" sort="Laitinen, Jaana" uniqKey="Laitinen J" first="Jaana" last="Laitinen">Jaana Laitinen</name><affiliation><nlm:aff id="A149"> Finnish Institute of Occupational Health, 90220 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Lantieri, Olivier" sort="Lantieri, Olivier" uniqKey="Lantieri O" first="Olivier" last="Lantieri">Olivier Lantieri</name><affiliation><nlm:aff id="A150"> Institut inter-regional pour la sante (IRSA), F-37521 La Riche, France</nlm:aff></affiliation></author><author><name sortKey="Lanzani, Chiara" sort="Lanzani, Chiara" uniqKey="Lanzani C" first="Chiara" last="Lanzani">Chiara Lanzani</name><affiliation><nlm:aff id="A73"> University Vita-Salute San Raffaele, Division of Nephrology and Dialysis, 20132 Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><affiliation><nlm:aff id="A151"> Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Lecoeur, Cecile" sort="Lecoeur, Cecile" uniqKey="Lecoeur C" first="Cecile" last="Lecoeur">Cecile Lecoeur</name><affiliation><nlm:aff id="A27"> CNRS UMR8199-IBL-Institut Pasteur de Lille, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A28"> University Lille Nord de France, 59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:aff id="A152"> Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, 33520 Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Lettre, Guillaume" sort="Lettre, Guillaume" uniqKey="Lettre G" first="Guillaume" last="Lettre">Guillaume Lettre</name><affiliation><nlm:aff id="A114"> Montreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A153"> Department of Medicine, Universite de Montreal, Montreal, Quebec, H3T 1J4, Canada</nlm:aff></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:aff id="A154"> Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore</nlm:aff></affiliation></author><author><name sortKey="Lokki, Marja Liisa" sort="Lokki, Marja Liisa" uniqKey="Lokki M" first="Marja-Liisa" last="Lokki">Marja-Liisa Lokki</name><affiliation><nlm:aff id="A155"> Transplantation Laboratory, Haartman Institute, University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Lorentzon, Mattias" sort="Lorentzon, Mattias" uniqKey="Lorentzon M" first="Mattias" last="Lorentzon">Mattias Lorentzon</name><affiliation><nlm:aff id="A156"> Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Luben, Robert N" sort="Luben, Robert N" uniqKey="Luben R" first="Robert N." last="Luben">Robert N. Luben</name><affiliation><nlm:aff id="A157"> Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge CB2 2SR, UK</nlm:aff></affiliation></author><author><name sortKey="Ludwig, Barbara" sort="Ludwig, Barbara" uniqKey="Ludwig B" first="Barbara" last="Ludwig">Barbara Ludwig</name><affiliation><nlm:aff id="A83"> Department of Medicine III, University of Dresden, 01307 Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Manunta, Paolo" sort="Manunta, Paolo" uniqKey="Manunta P" first="Paolo" last="Manunta">Paolo Manunta</name><affiliation><nlm:aff id="A73"> University Vita-Salute San Raffaele, Division of Nephrology and Dialysis, 20132 Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Marek, Diana" sort="Marek, Diana" uniqKey="Marek D" first="Diana" last="Marek">Diana Marek</name><affiliation><nlm:aff id="A33"> Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A34"> Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Marre, Michel" sort="Marre, Michel" uniqKey="Marre M" first="Michel" last="Marre">Michel Marre</name><affiliation><nlm:aff id="A159"> Department of Endocrinology, Diabetology and Nutrition, Bichat-Claude Bernard University Hospital, Assistance Publique des Hopitaux de Paris, F-75018 Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A160"> Cardiovascular Genetics Research Unit, Universite Henri Poincare-Nancy 1, 54000, Nancy, France</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="A161"> Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Queensland 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L." last="Mcardle">Wendy L. Mcardle</name><affiliation><nlm:aff id="A162"> Avon Longitudinal Study of Parents and Children (ALSPAC) Laboratory, Department of Social Medicine, University of Bristol, Bristol, BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Anne" sort="Mccarthy, Anne" uniqKey="Mccarthy A" first="Anne" last="Mccarthy">Anne Mccarthy</name><affiliation><nlm:aff id="A163"> Division of Health, Research Board, An Bord Taighde Slainte, Dublin, 2, Ireland</nlm:aff></affiliation></author><author><name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name><affiliation><nlm:aff id="A75"> Departments of Biostatistics, University of Washington, Seattle, Washington 98195, USA</nlm:aff></affiliation></author><author><name sortKey="Meitinger, Thomas" sort="Meitinger, Thomas" uniqKey="Meitinger T" first="Thomas" last="Meitinger">Thomas Meitinger</name><affiliation><nlm:aff id="A164"> Institute of Human Genetics, Klinikum rechts der Isar der Technischen Universitat Munchen, 81675 Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A165"> Institute of Human Genetics, Helmholtz Zentrum Munchen - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name><affiliation><nlm:aff id="A166"> Department of Clinical Sciences, Lund University, 20502 Malmo, Sweden</nlm:aff></affiliation></author><author><name sortKey="Meyre, David" sort="Meyre, David" uniqKey="Meyre D" first="David" last="Meyre">David Meyre</name><affiliation><nlm:aff id="A27"> CNRS UMR8199-IBL-Institut Pasteur de Lille, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A28"> University Lille Nord de France, 59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Midthjell, Kristian" sort="Midthjell, Kristian" uniqKey="Midthjell K" first="Kristian" last="Midthjell">Kristian Midthjell</name><affiliation><nlm:aff id="A148"> HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway</nlm:aff></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation><nlm:aff id="A167"> Molecular Epidemiology Laboratory, Queensland Institute of Medical Research, Queensland 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Morken, Mario A" sort="Morken, Mario A" uniqKey="Morken M" first="Mario A." last="Morken">Mario A. Morken</name><affiliation><nlm:aff id="A58"> National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Morris, Andrew P" sort="Morris, Andrew P" uniqKey="Morris A" first="Andrew P." last="Morris">Andrew P. Morris</name><affiliation><nlm:aff id="A8"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Mulic, Rosanda" sort="Mulic, Rosanda" uniqKey="Mulic R" first="Rosanda" last="Mulic">Rosanda Mulic</name><affiliation><nlm:aff id="A168"> Croatian Centre for Global Health, School of Medicine, University of Split, Split 21000, Croatia</nlm:aff></affiliation></author><author><name sortKey="Ngwa, Julius S" sort="Ngwa, Julius S" uniqKey="Ngwa J" first="Julius S." last="Ngwa">Julius S. Ngwa</name><affiliation><nlm:aff id="A67"> Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Nelis, Mari" sort="Nelis, Mari" uniqKey="Nelis M" first="Mari" last="Nelis">Mari Nelis</name><affiliation><nlm:aff id="A29"> Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A30"> Estonian Biocenter, Tartu 51010, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A31"> Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Neville, Matt J" sort="Neville, Matt J" uniqKey="Neville M" first="Matt J." last="Neville">Matt J. Neville</name><affiliation><nlm:aff id="A9"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Nyholt, Dale R" sort="Nyholt, Dale R" uniqKey="Nyholt D" first="Dale R." last="Nyholt">Dale R. Nyholt</name><affiliation><nlm:aff id="A169"> Neurogenetics Laboratory, Queensland Institute of Medical Research, Queensland 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="O Onnell, Christopher J" sort="O Onnell, Christopher J" uniqKey="O Onnell C" first="Christopher J." last="O Onnell">Christopher J. O Onnell</name><affiliation><nlm:aff id="A141"> Framingham Heart Study of the National, Heart, Lung, and Blood Institute and Boston University, Framingham, Massachusetts 01702, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A170"> National, Lung, and Blood Institute, National Institutes of Health, Framingham, Massachusetts 01702, USA</nlm:aff></affiliation></author><author><name sortKey="O Ahilly, Stephen" sort="O Ahilly, Stephen" uniqKey="O Ahilly S" first="Stephen" last="O Ahilly">Stephen O Ahilly</name><affiliation><nlm:aff id="A171"> University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Ong, Ken K" sort="Ong, Ken K" uniqKey="Ong K" first="Ken K." last="Ong">Ken K. Ong</name><affiliation><nlm:aff id="A10"> MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Oostra, Ben" sort="Oostra, Ben" uniqKey="Oostra B" first="Ben" last="Oostra">Ben Oostra</name><affiliation><nlm:aff id="A172"> Department of Clinical Genetics, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Pare, Guillaume" sort="Pare, Guillaume" uniqKey="Pare G" first="Guillaume" last="Paré">Guillaume Paré</name><affiliation><nlm:aff id="A173"> Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N3Z5, Canada</nlm:aff></affiliation></author><author><name sortKey="Parker, Alex N" sort="Parker, Alex N" uniqKey="Parker A" first="Alex N." last="Parker">Alex N. Parker</name><affiliation><nlm:aff id="A174"> Amgen, Cambridge, Massachusetts 02139, USA</nlm:aff></affiliation></author><author><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name><affiliation><nlm:aff id="A60"> Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A61"> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Pichler, Irene" sort="Pichler, Irene" uniqKey="Pichler I" first="Irene" last="Pichler">Irene Pichler</name><affiliation><nlm:aff id="A105"> Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, 39100, Italy. Affiliated Institute of the University of Lubeck, Lubeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Pietil Inen, Kirsi H" sort="Pietil Inen, Kirsi H" uniqKey="Pietil Inen K" first="Kirsi H." last="Pietil Inen">Kirsi H. Pietil Inen</name><affiliation><nlm:aff id="A175"> Finnish Twin Cohort Study, Department of Public Health, University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A176"> Obesity Research unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Platou, Carl G P" sort="Platou, Carl G P" uniqKey="Platou C" first="Carl G. P." last="Platou">Carl G. P. Platou</name><affiliation><nlm:aff id="A148"> HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A177"> Department of Medicine, Levanger Hospital, The Nord-Trøndelag Health Trust, 7600 Levanger, Norway</nlm:aff></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation><nlm:aff id="A145"> Andrija Stampar School of Public Health, Medical School, University of Zagreb, 10000 Zagreb, Croatia</nlm:aff></affiliation><affiliation><nlm:aff id="A178"> Gen-Info Ltd, 10000 Zagreb, Croatia</nlm:aff></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation><nlm:aff id="A117"> Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A179"> National Institute for Health and Welfare, 90101 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Rafelt, Suzanne" sort="Rafelt, Suzanne" uniqKey="Rafelt S" first="Suzanne" last="Rafelt">Suzanne Rafelt</name><affiliation><nlm:aff id="A180"> Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, LE3 9QP, UK</nlm:aff></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation><nlm:aff id="A181"> Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520 Turku, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A182"> The Department of Clinical Physiology, Turku University Hospital, 20520 Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Rayner, Nigel W" sort="Rayner, Nigel W" uniqKey="Rayner N" first="Nigel W." last="Rayner">Nigel W. Rayner</name><affiliation><nlm:aff id="A8"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A9"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Ridderstr Le, Martin" sort="Ridderstr Le, Martin" uniqKey="Ridderstr Le M" first="Martin" last="Ridderstr Le">Martin Ridderstr Le</name><affiliation><nlm:aff id="A166"> Department of Clinical Sciences, Lund University, 20502 Malmo, Sweden</nlm:aff></affiliation></author><author><name sortKey="Rief, Winfried" sort="Rief, Winfried" uniqKey="Rief W" first="Winfried" last="Rief">Winfried Rief</name><affiliation><nlm:aff id="A183"> Clinical Psychology and Psychotherapy, University of Marburg, 35032 Marburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Ruokonen, Aimo" sort="Ruokonen, Aimo" uniqKey="Ruokonen A" first="Aimo" last="Ruokonen">Aimo Ruokonen</name><affiliation><nlm:aff id="A184"> Department of Clinical Sciences/Clinical Chemistry, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Robertson, Neil R" sort="Robertson, Neil R" uniqKey="Robertson N" first="Neil R." last="Robertson">Neil R. Robertson</name><affiliation><nlm:aff id="A8"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A9"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Rzehak, Peter" sort="Rzehak, Peter" uniqKey="Rzehak P" first="Peter" last="Rzehak">Peter Rzehak</name><affiliation><nlm:aff id="A15"> Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A185"> Ludwig-Maximilians-Universität, Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, 81377 Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation><nlm:aff id="A118"> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Sanders, Alan R" sort="Sanders, Alan R" uniqKey="Sanders A" first="Alan R." last="Sanders">Alan R. Sanders</name><affiliation><nlm:aff id="A95"> Northshore University Healthsystem, Evanston, Ilinois 60201, USA</nlm:aff></affiliation></author><author><name sortKey="Sandhu, Manjinder S" sort="Sandhu, Manjinder S" uniqKey="Sandhu M" first="Manjinder S." last="Sandhu">Manjinder S. Sandhu</name><affiliation><nlm:aff id="A10"> MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A16"> Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A157"> Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge CB2 2SR, UK</nlm:aff></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation><nlm:aff id="A86"> Istituto di Neurogenetica e Neurofarmacologia del CNR, Monserrato, 09042, Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Saramies, Jouko" sort="Saramies, Jouko" uniqKey="Saramies J" first="Jouko" last="Saramies">Jouko Saramies</name><affiliation><nlm:aff id="A186"> South Karelia Central Hospital, 53130 Lappeenranta, Finland</nlm:aff></affiliation></author><author><name sortKey="Savolainen, Markku J" sort="Savolainen, Markku J" uniqKey="Savolainen M" first="Markku J." last="Savolainen">Markku J. Savolainen</name><affiliation><nlm:aff id="A187"> Department of Clinical Sciences/Internal Medicine, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Scherag, Susann" sort="Scherag, Susann" uniqKey="Scherag S" first="Susann" last="Scherag">Susann Scherag</name><affiliation><nlm:aff id="A123"> Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, 45147 Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Schipf, Sabine" sort="Schipf, Sabine" uniqKey="Schipf S" first="Sabine" last="Schipf">Sabine Schipf</name><affiliation><nlm:aff id="A110"> Institut fur Klinische Chemie und Laboratoriumsmedizin, Universitat Greifswald, 17475 Greifswald, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A188"> Institut für Community Medicine, 17489 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Schreiber, Stefan" sort="Schreiber, Stefan" uniqKey="Schreiber S" first="Stefan" last="Schreiber">Stefan Schreiber</name><affiliation><nlm:aff id="A189"> Christian-Albrechts-University, University Hospital Schleswig-Holstein, Institute for Clinical Molecular Biology and Department of Internal Medicine I, 24105 Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Schunkert, Heribert" sort="Schunkert, Heribert" uniqKey="Schunkert H" first="Heribert" last="Schunkert">Heribert Schunkert</name><affiliation><nlm:aff id="A190"> Universität zu Lübeck, Medizinische Klinik II, 23562 Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Silander, Kaisa" sort="Silander, Kaisa" uniqKey="Silander K" first="Kaisa" last="Silander">Kaisa Silander</name><affiliation><nlm:aff id="A60"> Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A61"> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Sinisalo, Juha" sort="Sinisalo, Juha" uniqKey="Sinisalo J" first="Juha" last="Sinisalo">Juha Sinisalo</name><affiliation><nlm:aff id="A191"> Division of Cardiology, Cardiovascular Laboratory, Helsinki University Central Hospital, 00029 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S." last="Siscovick">David S. Siscovick</name><affiliation><nlm:aff id="A45"> Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A192"> Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington 98195, USA</nlm:aff></affiliation></author><author><name sortKey="Smit, Jan H" sort="Smit, Jan H" uniqKey="Smit J" first="Jan H." last="Smit">Jan H. Smit</name><affiliation><nlm:aff id="A193"> Department of Psychiatry/EMGO Institute, VU University Medical Center, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation><nlm:aff id="A16"> Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A35"> Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Sovio, Ulla" sort="Sovio, Ulla" uniqKey="Sovio U" first="Ulla" last="Sovio">Ulla Sovio</name><affiliation><nlm:aff id="A91"> Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Stephens, Jonathan" sort="Stephens, Jonathan" uniqKey="Stephens J" first="Jonathan" last="Stephens">Jonathan Stephens</name><affiliation><nlm:aff id="A194"> Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A195"> NHS Blood and Transplant, Cambridge Centre, Cambridge, CB2 0PT, UK</nlm:aff></affiliation></author><author><name sortKey="Surakka, Ida" sort="Surakka, Ida" uniqKey="Surakka I" first="Ida" last="Surakka">Ida Surakka</name><affiliation><nlm:aff id="A60"> Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A61"> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Swift, Amy J" sort="Swift, Amy J" uniqKey="Swift A" first="Amy J." last="Swift">Amy J. Swift</name><affiliation><nlm:aff id="A58"> National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Tammesoo, Mari Liis" sort="Tammesoo, Mari Liis" uniqKey="Tammesoo M" first="Mari-Liis" last="Tammesoo">Mari-Liis Tammesoo</name><affiliation><nlm:aff id="A29"> Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</nlm:aff></affiliation></author><author><name sortKey="Tardif, Jean Claude" sort="Tardif, Jean Claude" uniqKey="Tardif J" first="Jean-Claude" last="Tardif">Jean-Claude Tardif</name><affiliation><nlm:aff id="A114"> Montreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A153"> Department of Medicine, Universite de Montreal, Montreal, Quebec, H3T 1J4, Canada</nlm:aff></affiliation></author><author><name sortKey="Teder Laving, Maris" sort="Teder Laving, Maris" uniqKey="Teder Laving M" first="Maris" last="Teder-Laving">Maris Teder-Laving</name><affiliation><nlm:aff id="A30"> Estonian Biocenter, Tartu 51010, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A31"> Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Teslovich, Tanya M" sort="Teslovich, Tanya M" uniqKey="Teslovich T" first="Tanya M." last="Teslovich">Tanya M. Teslovich</name><affiliation><nlm:aff id="A3"> Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Thompson, John R" sort="Thompson, John R" uniqKey="Thompson J" first="John R." last="Thompson">John R. Thompson</name><affiliation><nlm:aff id="A196"> Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, LE3 9QP, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A197"> Department of Health Sciences, University of Leicester, University Road, Leicester, LE1 7RH, UK</nlm:aff></affiliation></author><author><name sortKey="Thomson, Brian" sort="Thomson, Brian" uniqKey="Thomson B" first="Brian" last="Thomson">Brian Thomson</name><affiliation><nlm:aff id="A1"> Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name><affiliation><nlm:aff id="A198"> Department of Medicine, University of Leipzig, 04103 Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A199"> Coordination Centre for Clinical Trials, University of Leipzig, Härtelstr. 16-18, 04103 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Tuomi, Tiinamaija" sort="Tuomi, Tiinamaija" uniqKey="Tuomi T" first="Tiinamaija" last="Tuomi">Tiinamaija Tuomi</name><affiliation><nlm:aff id="A103"> Folkhalsan Research Centre, 00250 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A200"> Department of Medicine, Helsinki University Central Hospital, 00290 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A201"> Research Program of Molecular Medicine, University of Helsinki, 00014 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Van Meurs, Joyce B J" sort="Van Meurs, Joyce B J" uniqKey="Van Meurs J" first="Joyce B. J." last="Van Meurs">Joyce B. J. Van Meurs</name><affiliation><nlm:aff id="A20"> Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A21"> Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A22"> Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Van Ommen, Gert Jan" sort="Van Ommen, Gert Jan" uniqKey="Van Ommen G" first="Gert-Jan" last="Van Ommen">Gert-Jan Van Ommen</name><affiliation><nlm:aff id="A202"> Department of Human Genetics, Leiden University Medical Center, 2333 ZC Leiden, the Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A203"> Center of Medical Systems Biology, Leiden University Medical Center, 2333 ZC Leiden, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Vatin, Vincent" sort="Vatin, Vincent" uniqKey="Vatin V" first="Vincent" last="Vatin">Vincent Vatin</name><affiliation><nlm:aff id="A27"> CNRS UMR8199-IBL-Institut Pasteur de Lille, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A28"> University Lille Nord de France, 59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Viikari, Jorma" sort="Viikari, Jorma" uniqKey="Viikari J" first="Jorma" last="Viikari">Jorma Viikari</name><affiliation><nlm:aff id="A204"> Department of Medicine, University of Turku and Turku University Hospital, 20520 Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Visvikis Siest, Sophie" sort="Visvikis Siest, Sophie" uniqKey="Visvikis Siest S" first="Sophie" last="Visvikis-Siest">Sophie Visvikis-Siest</name><affiliation><nlm:aff id="A205"> INSERM Cardiovascular Genetics team, CIC 9501, 54000 Nancy, France</nlm:aff></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation><nlm:aff id="A119"> MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, Scotland, UK</nlm:aff></affiliation></author><author><name sortKey="Vogel, Carla I G" sort="Vogel, Carla I G" uniqKey="Vogel C" first="Carla I. G." last="Vogel">Carla I. G. Vogel</name><affiliation><nlm:aff id="A123"> Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, 45147 Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Voight, Benjamin F" sort="Voight, Benjamin F" uniqKey="Voight B" first="Benjamin F." last="Voight">Benjamin F. Voight</name><affiliation><nlm:aff id="A17"> Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A18"> Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A19"> Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation></author><author><name sortKey="Waite, Lindsay L" sort="Waite, Lindsay L" uniqKey="Waite L" first="Lindsay L." last="Waite">Lindsay L. Waite</name><affiliation><nlm:aff id="A41"> Hudson Alpha Institute for Biotechnology, Huntsville, Alabama 35806, USA</nlm:aff></affiliation></author><author><name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name><affiliation><nlm:aff id="A110"> Institut fur Klinische Chemie und Laboratoriumsmedizin, Universitat Greifswald, 17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Walters, G Bragi" sort="Walters, G Bragi" uniqKey="Walters G" first="G. Bragi" last="Walters">G. Bragi Walters</name><affiliation><nlm:aff id="A6"> deCODE Genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name><affiliation><nlm:aff id="A60"> Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Wiegand, Susanna" sort="Wiegand, Susanna" uniqKey="Wiegand S" first="Susanna" last="Wiegand">Susanna Wiegand</name><affiliation><nlm:aff id="A81"> Institute of Experimental Paediatric Endocrinology, Charite Universitatsmedizin Berlin, 13353 Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name><affiliation><nlm:aff id="A87"> Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</nlm:aff></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation><nlm:aff id="A50"> Department of Biological Psychology, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Witte, Daniel R" sort="Witte, Daniel R" uniqKey="Witte D" first="Daniel R." last="Witte">Daniel R. Witte</name><affiliation><nlm:aff id="A206"> Steno Diabetes Center, 2820 Gentofte, Denmark</nlm:aff></affiliation></author><author><name sortKey="Witteman, Jacqueline C" sort="Witteman, Jacqueline C" uniqKey="Witteman J" first="Jacqueline C." last="Witteman">Jacqueline C. Witteman</name><affiliation><nlm:aff id="A20"> Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A22"> Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Xu, Jianfeng" sort="Xu, Jianfeng" uniqKey="Xu J" first="Jianfeng" last="Xu">Jianfeng Xu</name><affiliation><nlm:aff id="A207"> Center for Human Genomics, Wake Forest University, Winston-Salem, North Carolina 27157, USA</nlm:aff></affiliation></author><author><name sortKey="Zhang, Qunyuan" sort="Zhang, Qunyuan" uniqKey="Zhang Q" first="Qunyuan" last="Zhang">Qunyuan Zhang</name><affiliation><nlm:aff id="A32"> Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Zgaga, Lina" sort="Zgaga, Lina" uniqKey="Zgaga L" first="Lina" last="Zgaga">Lina Zgaga</name><affiliation><nlm:aff id="A145"> Andrija Stampar School of Public Health, Medical School, University of Zagreb, 10000 Zagreb, Croatia</nlm:aff></affiliation></author><author><name sortKey="Ziegler, Andreas" sort="Ziegler, Andreas" uniqKey="Ziegler A" first="Andreas" last="Ziegler">Andreas Ziegler</name><affiliation><nlm:aff id="A59"> Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Universitatsklinikum Schleswig-Holstein, Campus Lubeck, 23562 Lubeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Zitting, Paavo" sort="Zitting, Paavo" uniqKey="Zitting P" first="Paavo" last="Zitting">Paavo Zitting</name><affiliation><nlm:aff id="A208"> Department of Physiatrics, Lapland Central Hospital, 96101 Rovaniemi, Finland</nlm:aff></affiliation></author><author><name sortKey="Beilby, John P" sort="Beilby, John P" uniqKey="Beilby J" first="John P." last="Beilby">John P. Beilby</name><affiliation><nlm:aff id="A125"> PathWest Laboratory of Western Australia, Department of Molecular Genetics, J Block, QEII Medical Centre, Nedlands, Western Australia 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A126"> Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A209"> School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="Farooqi, I Sadaf" sort="Farooqi, I Sadaf" uniqKey="Farooqi I" first="I. Sadaf" last="Farooqi">I. Sadaf Farooqi</name><affiliation><nlm:aff id="A171"> University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Hebebrand, Johannes" sort="Hebebrand, Johannes" uniqKey="Hebebrand J" first="Johannes" last="Hebebrand">Johannes Hebebrand</name><affiliation><nlm:aff id="A123"> Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, 45147 Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Huikuri, Heikki V" sort="Huikuri, Heikki V" uniqKey="Huikuri H" first="Heikki V." last="Huikuri">Heikki V. Huikuri</name><affiliation><nlm:aff id="A210"> Department of Internal Medicine, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A210"> Department of Internal Medicine, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="James, Alan L" sort="James, Alan L" uniqKey="James A" first="Alan L." last="James">Alan L. James</name><affiliation><nlm:aff id="A126"> Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A211"> School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:aff id="A212"> Department of Clinical Physiology, University of Tampere and Tampere University Hospital, 33520 Tampere, Finland;</nlm:aff></affiliation></author><author><name sortKey="Levinson, Douglas F" sort="Levinson, Douglas F" uniqKey="Levinson D" first="Douglas F." last="Levinson">Douglas F. Levinson</name><affiliation><nlm:aff id="A213"> Stanford University School of Medicine, Stanford, California 93405, USA</nlm:aff></affiliation></author><author><name sortKey="Macciardi, Fabio" sort="Macciardi, Fabio" uniqKey="Macciardi F" first="Fabio" last="Macciardi">Fabio Macciardi</name><affiliation><nlm:aff id="A68"> University of Milan, Department of Medicine, Surgery and Dentistry, 20139 Milano, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A214"> Department of Psychiatry and Human Behavior, University of California, Irvine (UCI), Irvine, California 92617, USA</nlm:aff></affiliation></author><author><name sortKey="Nieminen, Markku S" sort="Nieminen, Markku S" uniqKey="Nieminen M" first="Markku S." last="Nieminen">Markku S. Nieminen</name><affiliation><nlm:aff id="A191"> Division of Cardiology, Cardiovascular Laboratory, Helsinki University Central Hospital, 00029 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A191"> Division of Cardiology, Cardiovascular Laboratory, Helsinki University Central Hospital, 00029 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Ohlsson, Claes" sort="Ohlsson, Claes" uniqKey="Ohlsson C" first="Claes" last="Ohlsson">Claes Ohlsson</name><affiliation><nlm:aff id="A156"> Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J." last="Palmer">Lyle J. Palmer</name><affiliation><nlm:aff id="A71"> Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A126"> Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name><affiliation><nlm:aff id="A69"> Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts 02215, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A70"> Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation><nlm:aff id="A198"> Department of Medicine, University of Leipzig, 04103 Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A215"> LIFE Study Centre, University of Leipzig, Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Jacques S" sort="Beckmann, Jacques S" uniqKey="Beckmann J" first="Jacques S." last="Beckmann">Jacques S. Beckmann</name><affiliation><nlm:aff id="A33"> Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A216"> Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, 1011 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation><nlm:aff id="A43"> Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany</nlm:aff></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation><nlm:aff id="A217"> Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:aff id="A50"> Department of Biological Psychology, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Caulfield, Mark J" sort="Caulfield, Mark J" uniqKey="Caulfield M" first="Mark J." last="Caulfield">Mark J. Caulfield</name><affiliation><nlm:aff id="A54"> Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="A4"> Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Collins, Francis S" sort="Collins, Francis S" uniqKey="Collins F" first="Francis S." last="Collins">Francis S. Collins</name><affiliation><nlm:aff id="A58"> National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Cupples, L Adrienne" sort="Cupples, L Adrienne" uniqKey="Cupples L" first="L. Adrienne" last="Cupples">L. Adrienne Cupples</name><affiliation><nlm:aff id="A67"> Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><affiliation><nlm:aff id="A63"> MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, Oakfield House, Bristol, BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Erdmann, Jeanette" sort="Erdmann, Jeanette" uniqKey="Erdmann J" first="Jeanette" last="Erdmann">Jeanette Erdmann</name><affiliation><nlm:aff id="A190"> Universität zu Lübeck, Medizinische Klinik II, 23562 Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="A27"> CNRS UMR8199-IBL-Institut Pasteur de Lille, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A28"> University Lille Nord de France, 59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A82"> Department of Genomics of Common Disease, School of Public Health, Imperial College London, W12 0NN, London, UK</nlm:aff></affiliation></author><author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name><affiliation><nlm:aff id="A25"> Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation><nlm:aff id="A51"> Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, SE-75185 Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="A25"> Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hansen, Torben" sort="Hansen, Torben" uniqKey="Hansen T" first="Torben" last="Hansen">Torben Hansen</name><affiliation><nlm:aff id="A62"> Hagedorn Research Institute, 2820 Gentofte, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A218"> Faculty of Health Science, University of Southern Denmark, 5000 Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="A151"> Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Hattersley, Andrew T" sort="Hattersley, Andrew T" uniqKey="Hattersley A" first="Andrew T." last="Hattersley">Andrew T. Hattersley</name><affiliation><nlm:aff id="A7"> Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, EX1 2LU, UK</nlm:aff></affiliation></author><author><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B." last="Hayes">Richard B. Hayes</name><affiliation><nlm:aff id="A219"> New York University Medical Center, New York, New York 10016, USA</nlm:aff></affiliation></author><author><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name><affiliation><nlm:aff id="A15"> Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B." last="Hu">Frank B. Hu</name><affiliation><nlm:aff id="A13"> Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A14"> Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A23"> Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Hveem, Kristian" sort="Hveem, Kristian" uniqKey="Hveem K" first="Kristian" last="Hveem">Kristian Hveem</name><affiliation><nlm:aff id="A148"> HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway</nlm:aff></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation><nlm:aff id="A15"> Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation><nlm:aff id="A91"> Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, W2 1PG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A136"> Institute of Health Sciences, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A137"> Biocenter Oulu, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A179"> National Institute for Health and Welfare, 90101 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation><nlm:aff id="A60"> Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A175"> Finnish Twin Cohort Study, Department of Public Health, University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A220"> National Institute for Health and Welfare, Department of Mental Health and Substance Abuse Services, Unit for Child and Adolescent Mental Health, 00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Karpe, Fredrik" sort="Karpe, Fredrik" uniqKey="Karpe F" first="Fredrik" last="Karpe">Fredrik Karpe</name><affiliation><nlm:aff id="A9"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A221"> NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:aff id="A157"> Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge CB2 2SR, UK</nlm:aff></affiliation></author><author><name sortKey="Kiemeney, Lambertus A" sort="Kiemeney, Lambertus A" uniqKey="Kiemeney L" first="Lambertus A." last="Kiemeney">Lambertus A. Kiemeney</name><affiliation><nlm:aff id="A40"> Comprehensive Cancer Center East, 6501 BG Nijmegen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A93"> Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A222"> Department of Urology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Krude, Heiko" sort="Krude, Heiko" uniqKey="Krude H" first="Heiko" last="Krude">Heiko Krude</name><affiliation><nlm:aff id="A81"> Institute of Experimental Paediatric Endocrinology, Charite Universitatsmedizin Berlin, 13353 Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Laakso, Markku" sort="Laakso, Markku" uniqKey="Laakso M" first="Markku" last="Laakso">Markku Laakso</name><affiliation><nlm:aff id="A147"> Department of Medicine, University of Kuopio and Kuopio University Hospital, 70210 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Lawlor, Debbie A" sort="Lawlor, Debbie A" uniqKey="Lawlor D" first="Debbie A." last="Lawlor">Debbie A. Lawlor</name><affiliation><nlm:aff id="A63"> MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, Oakfield House, Bristol, BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation><nlm:aff id="A29"> Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A30"> Estonian Biocenter, Tartu 51010, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A31"> Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Munroe, Patricia B" sort="Munroe, Patricia B" uniqKey="Munroe P" first="Patricia B." last="Munroe">Patricia B. Munroe</name><affiliation><nlm:aff id="A54"> Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK</nlm:aff></affiliation></author><author><name sortKey="Ouwehand, Willem H" sort="Ouwehand, Willem H" uniqKey="Ouwehand W" first="Willem H." last="Ouwehand">Willem H. Ouwehand</name><affiliation><nlm:aff id="A16"> Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A194"> Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A195"> NHS Blood and Transplant, Cambridge Centre, Cambridge, CB2 0PT, UK</nlm:aff></affiliation></author><author><name sortKey="Pedersen, Oluf" sort="Pedersen, Oluf" uniqKey="Pedersen O" first="Oluf" last="Pedersen">Oluf Pedersen</name><affiliation><nlm:aff id="A62"> Hagedorn Research Institute, 2820 Gentofte, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A223"> Institute of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A224"> Faculty of Health Science, University of Aarhus, 8000 Aarhus, Denmark</nlm:aff></affiliation></author><author><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W." last="Penninx">Brenda W. Penninx</name><affiliation><nlm:aff id="A193"> Department of Psychiatry/EMGO Institute, VU University Medical Center, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A225"> Department of Psychiatry, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A226"> Department of Psychiatry, University Medical Centre Groningen, 9713 GZ Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name><affiliation><nlm:aff id="A15"> Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><affiliation><nlm:aff id="A105"> Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, 39100, Italy. Affiliated Institute of the University of Lubeck, Lubeck, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A106"> Department of Neurology, General Central Hospital, Bolzano, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A227"> Department of Neurology, University of Lübeck, Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Quertermous, Thomas" sort="Quertermous, Thomas" uniqKey="Quertermous T" first="Thomas" last="Quertermous">Thomas Quertermous</name><affiliation><nlm:aff id="A144"> Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA</nlm:aff></affiliation></author><author><name sortKey="Reinehr, Thomas" sort="Reinehr, Thomas" uniqKey="Reinehr T" first="Thomas" last="Reinehr">Thomas Reinehr</name><affiliation><nlm:aff id="A228"> Institute for Paediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents, University of Witten-Herdecke, 45711 Datteln, Germany</nlm:aff></affiliation></author><author><name sortKey="Rissanen, Aila" sort="Rissanen, Aila" uniqKey="Rissanen A" first="Aila" last="Rissanen">Aila Rissanen</name><affiliation><nlm:aff id="A176"> Obesity Research unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="A87"> Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</nlm:aff></affiliation><affiliation><nlm:aff id="A168"> Croatian Centre for Global Health, School of Medicine, University of Split, Split 21000, Croatia</nlm:aff></affiliation></author><author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name><affiliation><nlm:aff id="A180"> Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, LE3 9QP, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A196"> Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, LE3 9QP, UK</nlm:aff></affiliation></author><author><name sortKey="Schwarz, Peter E H" sort="Schwarz, Peter E H" uniqKey="Schwarz P" first="Peter E. H." last="Schwarz">Peter E. H. Schwarz</name><affiliation><nlm:aff id="A229"> Department of Medicine III, Prevention and Care of Diabetes, University of Dresden, 01307 Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name><affiliation><nlm:aff id="A112"> Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A230"> Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, Maryland 21201, USA</nlm:aff></affiliation></author><author><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D." last="Spector">Timothy D. Spector</name><affiliation><nlm:aff id="A35"> Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Tuomilehto, Jaakko" sort="Tuomilehto, Jaakko" uniqKey="Tuomilehto J" first="Jaakko" last="Tuomilehto">Jaakko Tuomilehto</name><affiliation><nlm:aff id="A143"> National Institute for Health and Welfare, Diabetes Prevention Unit, 00271 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A231"> Hjelt Institute, Department of Public Health, University of Helsinki, 00014 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A232"> South Ostrobothnia Central Hospital, 60220 Seinajoki, Finland</nlm:aff></affiliation></author><author><name sortKey="Uda, Manuela" sort="Uda, Manuela" uniqKey="Uda M" first="Manuela" last="Uda">Manuela Uda</name><affiliation><nlm:aff id="A86"> Istituto di Neurogenetica e Neurofarmacologia del CNR, Monserrato, 09042, Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre" sort="Uitterlinden, Andre" uniqKey="Uitterlinden A" first="André" last="Uitterlinden">André Uitterlinden</name><affiliation><nlm:aff id="A20"> Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A21"> Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A22"> Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Valle, Timo T" sort="Valle, Timo T" uniqKey="Valle T" first="Timo T." last="Valle">Timo T. Valle</name><affiliation><nlm:aff id="A143"> National Institute for Health and Welfare, Diabetes Prevention Unit, 00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Wabitsch, Martin" sort="Wabitsch, Martin" uniqKey="Wabitsch M" first="Martin" last="Wabitsch">Martin Wabitsch</name><affiliation><nlm:aff id="A108"> Pediatric Endocrinology, Diabetes and Obesity Unit, Department of Pediatrics and Adolescent Medicine, 89075 Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Waeber, Gerard" sort="Waeber, Gerard" uniqKey="Waeber G" first="Gérard" last="Waeber">Gérard Waeber</name><affiliation><nlm:aff id="A233"> Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, 1011 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A10"> MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name><affiliation><nlm:aff id="A8"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A113"> Department of Cardiovascular Medicine, University of Oxford, Level 6 West Wing, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU</nlm:aff></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="A87"> Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</nlm:aff></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name><affiliation><nlm:aff id="A119"> MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, Scotland, UK</nlm:aff></affiliation></author><author><name sortKey="Zillikens, M Carola" sort="Zillikens, M Carola" uniqKey="Zillikens M" first="M. Carola" last="Zillikens">M. Carola Zillikens</name><affiliation><nlm:aff id="A21"> Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A22"> Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Chatterjee, Nilanjan" sort="Chatterjee, Nilanjan" uniqKey="Chatterjee N" first="Nilanjan" last="Chatterjee">Nilanjan Chatterjee</name><affiliation><nlm:aff id="A4"> Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Mccarroll, Steven A" sort="Mccarroll, Steven A" uniqKey="Mccarroll S" first="Steven A." last="Mccarroll">Steven A. Mccarroll</name><affiliation><nlm:aff id="A17"> Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A18"> Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A19"> Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation></author><author><name sortKey="Purcell, Shaun" sort="Purcell, Shaun" uniqKey="Purcell S" first="Shaun" last="Purcell">Shaun Purcell</name><affiliation><nlm:aff id="A17"> Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A234"> The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A235"> Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Schadt, Eric E" sort="Schadt, Eric E" uniqKey="Schadt E" first="Eric E." last="Schadt">Eric E. Schadt</name><affiliation><nlm:aff id="A236"> Pacific Biosciences, Menlo Park, California 94025, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A237"> Sage Bionetworks, Seattle, Washington 98109, USA</nlm:aff></affiliation></author><author><name sortKey="Visscher, Peter M" sort="Visscher, Peter M" uniqKey="Visscher P" first="Peter M." last="Visscher">Peter M. Visscher</name><affiliation><nlm:aff id="A26"> Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Queensland 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Assimes, Themistocles L" sort="Assimes, Themistocles L" uniqKey="Assimes T" first="Themistocles L." last="Assimes">Themistocles L. Assimes</name><affiliation><nlm:aff id="A144"> Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA</nlm:aff></affiliation></author><author><name sortKey="Borecki, Ingrid B" sort="Borecki, Ingrid B" uniqKey="Borecki I" first="Ingrid B." last="Borecki">Ingrid B. Borecki</name><affiliation><nlm:aff id="A32"> Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A238"> Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name><affiliation><nlm:aff id="A16"> Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S." last="Fox">Caroline S. Fox</name><affiliation><nlm:aff id="A239"> Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham Heart Study, Framingham, Massachusetts 01702, USA</nlm:aff></affiliation></author><author><name sortKey="Groop, Leif C" sort="Groop, Leif C" uniqKey="Groop L" first="Leif C." last="Groop">Leif C. Groop</name><affiliation><nlm:aff id="A74"> Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, 20502 Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Haritunians, Talin" sort="Haritunians, Talin" uniqKey="Haritunians T" first="Talin" last="Haritunians">Talin Haritunians</name><affiliation><nlm:aff id="A89"> Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA</nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="A13"> Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A14"> Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A23"> Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Kaplan, Robert C" sort="Kaplan, Robert C" uniqKey="Kaplan R" first="Robert C." last="Kaplan">Robert C. Kaplan</name><affiliation><nlm:aff id="A240"> Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA</nlm:aff></affiliation></author><author><name sortKey="Mohlke, Karen L" sort="Mohlke, Karen L" uniqKey="Mohlke K" first="Karen L." last="Mohlke">Karen L. Mohlke</name><affiliation><nlm:aff id="A241"> Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA</nlm:aff></affiliation></author><author><name sortKey="O Onnell, Jeffrey R" sort="O Onnell, Jeffrey R" uniqKey="O Onnell J" first="Jeffrey R." last="O Onnell">Jeffrey R. O Onnell</name><affiliation><nlm:aff id="A112"> Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</nlm:aff></affiliation></author><author><name sortKey="Peltonen, Leena" sort="Peltonen, Leena" uniqKey="Peltonen L" first="Leena" last="Peltonen">Leena Peltonen</name><affiliation><nlm:aff id="A16"> Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A60"> Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A61"> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A234"> The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A242"> Department of Medical Genetics, University of Helsinki, 00014 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Schlessinger, David" sort="Schlessinger, David" uniqKey="Schlessinger D" first="David" last="Schlessinger">David Schlessinger</name><affiliation><nlm:aff id="A243"> Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224, USA</nlm:aff></affiliation></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P." last="Strachan">David P. Strachan</name><affiliation><nlm:aff id="A244"> Division of Community Health Sciences, St George’s, University of London, London, SW17 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A20"> Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A22"> Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H.-Erich" last="Wichmann">H.-Erich Wichmann</name><affiliation><nlm:aff id="A15"> Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A185"> Ludwig-Maximilians-Universität, Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, 81377 Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A245"> Klinikum Grosshadern, 81377 Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Frayling, Timothy M" sort="Frayling, Timothy M" uniqKey="Frayling T" first="Timothy M." last="Frayling">Timothy M. Frayling</name><affiliation><nlm:aff id="A7"> Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, EX1 2LU, UK</nlm:aff></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation><nlm:aff id="A6"> deCODE Genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A246"> Faculty of Medicine, University of Iceland, 101 Reykjavík, Iceland</nlm:aff></affiliation></author><author><name sortKey="Abecasis, Goncalo R" sort="Abecasis, Goncalo R" uniqKey="Abecasis G" first="Gonçalo R." last="Abecasis">Gonçalo R. Abecasis</name><affiliation><nlm:aff id="A3"> Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Barroso, Ines" sort="Barroso, Ines" uniqKey="Barroso I" first="Inês" last="Barroso">Inês Barroso</name><affiliation><nlm:aff id="A16"> Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A247"> University of Cambridge Metabolic Research Labs, Institute of Metabolic Science Addenbrooke’s Hospital, CB2 OQQ, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Boehnke, Michael" sort="Boehnke, Michael" uniqKey="Boehnke M" first="Michael" last="Boehnke">Michael Boehnke</name><affiliation><nlm:aff id="A3"> Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><nlm:aff id="A6"> deCODE Genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A246"> Faculty of Medicine, University of Iceland, 101 Reykjavík, Iceland</nlm:aff></affiliation></author><author><name sortKey="North, Kari E" sort="North, Kari E" uniqKey="North K" first="Kari E." last="North">Kari E. North</name><affiliation><nlm:aff id="A5"> Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A248"> Carolina Center for Genome Sciences, School of Public Health, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27514, USA</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I." last="Mccarthy">Mark I. Mccarthy</name><affiliation><nlm:aff id="A8"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A9"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A221"> NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N." last="Hirschhorn">Joel N. Hirschhorn</name><affiliation><nlm:aff id="A1"> Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A11"> Divisions of Genetics and Endocrinology and Program in Genomics, Children’s Hospital, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A249"> Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation><nlm:aff id="A25"> Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J. F." last="Loos">Ruth J. F. Loos</name><affiliation><nlm:aff id="A10"> MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20935630</idno><idno type="pmc">3014648</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014648</idno><idno type="RBID">PMC:3014648</idno><idno type="doi">10.1038/ng.686</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">002E04</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E04</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association analyses of 249,796 individuals reveal eighteen new loci
associated with body mass index</title><author><name sortKey="Speliotes, Elizabeth K" sort="Speliotes, Elizabeth K" uniqKey="Speliotes E" first="Elizabeth K." last="Speliotes">Elizabeth K. Speliotes</name><affiliation><nlm:aff id="A1"> Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation></author><author><name sortKey="Willer, Cristen J" sort="Willer, Cristen J" uniqKey="Willer C" first="Cristen J." last="Willer">Cristen J. Willer</name><affiliation><nlm:aff id="A3"> Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><affiliation><nlm:aff id="A4"> Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Monda, Keri L" sort="Monda, Keri L" uniqKey="Monda K" first="Keri L." last="Monda">Keri L. Monda</name><affiliation><nlm:aff id="A5"> Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, USA</nlm:aff></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation><nlm:aff id="A6"> deCODE Genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Jackson, Anne U" sort="Jackson, Anne U" uniqKey="Jackson A" first="Anne U." last="Jackson">Anne U. Jackson</name><affiliation><nlm:aff id="A3"> Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Allen, Hana Lango" sort="Allen, Hana Lango" uniqKey="Allen H" first="Hana Lango" last="Allen">Hana Lango Allen</name><affiliation><nlm:aff id="A7"> Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, EX1 2LU, UK</nlm:aff></affiliation></author><author><name sortKey="Lindgren, Cecilia M" sort="Lindgren, Cecilia M" uniqKey="Lindgren C" first="Cecilia M." last="Lindgren">Cecilia M. Lindgren</name><affiliation><nlm:aff id="A8"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A9"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Luan, Jian N" sort="Luan, Jian N" uniqKey="Luan J" first="Jian N" last="Luan">Jian N Luan</name><affiliation><nlm:aff id="A10"> MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><affiliation><nlm:aff id="A8"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Randall, Joshua C" sort="Randall, Joshua C" uniqKey="Randall J" first="Joshua C." last="Randall">Joshua C. Randall</name><affiliation><nlm:aff id="A8"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Vedantam, Sailaja" sort="Vedantam, Sailaja" uniqKey="Vedantam S" first="Sailaja" last="Vedantam">Sailaja Vedantam</name><affiliation><nlm:aff id="A1"> Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A11"> Divisions of Genetics and Endocrinology and Program in Genomics, Children’s Hospital, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Winkler, Thomas W" sort="Winkler, Thomas W" uniqKey="Winkler T" first="Thomas W." last="Winkler">Thomas W. Winkler</name><affiliation><nlm:aff id="A12"> Regensburg University Medical Center, Department of Epidemiology and Preventive Medicine, 93053 Regensburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Qi, Lu" sort="Qi, Lu" uniqKey="Qi L" first="Lu" last="Qi">Lu Qi</name><affiliation><nlm:aff id="A13"> Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A14"> Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Workalemahu, Tsegaselassie" sort="Workalemahu, Tsegaselassie" uniqKey="Workalemahu T" first="Tsegaselassie" last="Workalemahu">Tsegaselassie Workalemahu</name><affiliation><nlm:aff id="A13"> Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M." last="Heid">Iris M. Heid</name><affiliation><nlm:aff id="A12"> Regensburg University Medical Center, Department of Epidemiology and Preventive Medicine, 93053 Regensburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A15"> Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Steinthorsdottir, Valgerdur" sort="Steinthorsdottir, Valgerdur" uniqKey="Steinthorsdottir V" first="Valgerdur" last="Steinthorsdottir">Valgerdur Steinthorsdottir</name><affiliation><nlm:aff id="A6"> deCODE Genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Stringham, Heather M" sort="Stringham, Heather M" uniqKey="Stringham H" first="Heather M." last="Stringham">Heather M. Stringham</name><affiliation><nlm:aff id="A3"> Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Weedon, Michael N" sort="Weedon, Michael N" uniqKey="Weedon M" first="Michael N." last="Weedon">Michael N. Weedon</name><affiliation><nlm:aff id="A7"> Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, EX1 2LU, UK</nlm:aff></affiliation></author><author><name sortKey="Wheeler, Eleanor" sort="Wheeler, Eleanor" uniqKey="Wheeler E" first="Eleanor" last="Wheeler">Eleanor Wheeler</name><affiliation><nlm:aff id="A16"> Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Wood, Andrew R" sort="Wood, Andrew R" uniqKey="Wood A" first="Andrew R." last="Wood">Andrew R. Wood</name><affiliation><nlm:aff id="A7"> Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, EX1 2LU, UK</nlm:aff></affiliation></author><author><name sortKey="Ferreira, Teresa" sort="Ferreira, Teresa" uniqKey="Ferreira T" first="Teresa" last="Ferreira">Teresa Ferreira</name><affiliation><nlm:aff id="A8"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Weyant, Robert J" sort="Weyant, Robert J" uniqKey="Weyant R" first="Robert J." last="Weyant">Robert J. Weyant</name><affiliation><nlm:aff id="A3"> Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Segre, Ayellet V" sort="Segre, Ayellet V" uniqKey="Segre A" first="Ayellet V." last="Segré">Ayellet V. Segré</name><affiliation><nlm:aff id="A17"> Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A18"> Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A19"> Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation></author><author><name sortKey="Estrada, Karol" sort="Estrada, Karol" uniqKey="Estrada K" first="Karol" last="Estrada">Karol Estrada</name><affiliation><nlm:aff id="A20"> Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A21"> Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A22"> Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Liang, Liming" sort="Liang, Liming" uniqKey="Liang L" first="Liming" last="Liang">Liming Liang</name><affiliation><nlm:aff id="A23"> Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A24"> Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Nemesh, James" sort="Nemesh, James" uniqKey="Nemesh J" first="James" last="Nemesh">James Nemesh</name><affiliation><nlm:aff id="A18"> Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation></author><author><name sortKey="Park, Ju Hyun" sort="Park, Ju Hyun" uniqKey="Park J" first="Ju-Hyun" last="Park">Ju-Hyun Park</name><affiliation><nlm:aff id="A4"> Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Gustafsson, Stefan" sort="Gustafsson, Stefan" uniqKey="Gustafsson S" first="Stefan" last="Gustafsson">Stefan Gustafsson</name><affiliation><nlm:aff id="A25"> Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kilpel Inen, Tuomas O" sort="Kilpel Inen, Tuomas O" uniqKey="Kilpel Inen T" first="Tuomas O." last="Kilpel Inen">Tuomas O. Kilpel Inen</name><affiliation><nlm:aff id="A10"> MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Yang, Jian" sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name><affiliation><nlm:aff id="A26"> Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Queensland 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name><affiliation><nlm:aff id="A27"> CNRS UMR8199-IBL-Institut Pasteur de Lille, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A28"> University Lille Nord de France, 59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation><nlm:aff id="A29"> Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A30"> Estonian Biocenter, Tartu 51010, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A31"> Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Feitosa, Mary F" sort="Feitosa, Mary F" uniqKey="Feitosa M" first="Mary F." last="Feitosa">Mary F. Feitosa</name><affiliation><nlm:aff id="A32"> Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name><affiliation><nlm:aff id="A33"> Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A34"> Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation><nlm:aff id="A35"> Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Raychaudhuri, Soumya" sort="Raychaudhuri, Soumya" uniqKey="Raychaudhuri S" first="Soumya" last="Raychaudhuri">Soumya Raychaudhuri</name><affiliation><nlm:aff id="A18"> Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A36"> Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115 USA</nlm:aff></affiliation></author><author><name sortKey="Scherag, Andre" sort="Scherag, Andre" uniqKey="Scherag A" first="Andre" last="Scherag">Andre Scherag</name><affiliation><nlm:aff id="A37"> Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, 45122 Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name><affiliation><nlm:aff id="A38"> Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A39"> University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Welch, Ryan" sort="Welch, Ryan" uniqKey="Welch R" first="Ryan" last="Welch">Ryan Welch</name><affiliation><nlm:aff id="A3"> Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="A10"> MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Aben, Katja K" sort="Aben, Katja K" uniqKey="Aben K" first="Katja K." last="Aben">Katja K. Aben</name><affiliation><nlm:aff id="A40"> Comprehensive Cancer Center East, 6501 BG Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Absher, Devin M" sort="Absher, Devin M" uniqKey="Absher D" first="Devin M." last="Absher">Devin M. Absher</name><affiliation><nlm:aff id="A41"> Hudson Alpha Institute for Biotechnology, Huntsville, Alabama 35806, USA</nlm:aff></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation><nlm:aff id="A20"> Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Dixon, Anna L" sort="Dixon, Anna L" uniqKey="Dixon A" first="Anna L." last="Dixon">Anna L. Dixon</name><affiliation><nlm:aff id="A42"> Department of Pharmacy and Pharmacology, University of Bath, Bath, BA1 1RL, UK</nlm:aff></affiliation></author><author><name sortKey="Fisher, Eva" sort="Fisher, Eva" uniqKey="Fisher E" first="Eva" last="Fisher">Eva Fisher</name><affiliation><nlm:aff id="A43"> Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany</nlm:aff></affiliation></author><author><name sortKey="Glazer, Nicole L" sort="Glazer, Nicole L" uniqKey="Glazer N" first="Nicole L." last="Glazer">Nicole L. Glazer</name><affiliation><nlm:aff id="A44"> Department of Medicine, University of Washington, Seattle, Washington 98101, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A45"> Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA</nlm:aff></affiliation></author><author><name sortKey="Goddard, Michael E" sort="Goddard, Michael E" uniqKey="Goddard M" first="Michael E." last="Goddard">Michael E. Goddard</name><affiliation><nlm:aff id="A46"> University of Melbourne, Parkville 3010, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A47"> Department of Primary Industries, Melbourne, Victoria 3001, Australia</nlm:aff></affiliation></author><author><name sortKey="Heard Costa, Nancy L" sort="Heard Costa, Nancy L" uniqKey="Heard Costa N" first="Nancy L." last="Heard-Costa">Nancy L. Heard-Costa</name><affiliation><nlm:aff id="A48"> Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Hoesel, Volker" sort="Hoesel, Volker" uniqKey="Hoesel V" first="Volker" last="Hoesel">Volker Hoesel</name><affiliation><nlm:aff id="A49"> Technical University Munich, Chair of Biomathematics, Boltzmannstrasse 3, 85748 Garching</nlm:aff></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation><nlm:aff id="A50"> Department of Biological Psychology, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation><nlm:aff id="A51"> Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, SE-75185 Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A52"> Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, N-7489, Norway</nlm:aff></affiliation></author><author><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name><affiliation><nlm:aff id="A33"> Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A34"> Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A53"> Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A54"> Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK</nlm:aff></affiliation></author><author><name sortKey="Ketkar, Shamika" sort="Ketkar, Shamika" uniqKey="Ketkar S" first="Shamika" last="Ketkar">Shamika Ketkar</name><affiliation><nlm:aff id="A32"> Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Lamina, Claudia" sort="Lamina, Claudia" uniqKey="Lamina C" first="Claudia" last="Lamina">Claudia Lamina</name><affiliation><nlm:aff id="A15"> Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A55"> Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria</nlm:aff></affiliation></author><author><name sortKey="Li, Shengxu" sort="Li, Shengxu" uniqKey="Li S" first="Shengxu" last="Li">Shengxu Li</name><affiliation><nlm:aff id="A10"> MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Moffatt, Miriam F" sort="Moffatt, Miriam F" uniqKey="Moffatt M" first="Miriam F." last="Moffatt">Miriam F. Moffatt</name><affiliation><nlm:aff id="A56"> National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK</nlm:aff></affiliation></author><author><name sortKey="Myers, Richard H" sort="Myers, Richard H" uniqKey="Myers R" first="Richard H." last="Myers">Richard H. Myers</name><affiliation><nlm:aff id="A57"> Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Narisu, Narisu" sort="Narisu, Narisu" uniqKey="Narisu N" first="Narisu" last="Narisu">Narisu Narisu</name><affiliation><nlm:aff id="A58"> National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Perry, John R B" sort="Perry, John R B" uniqKey="Perry J" first="John R. B." last="Perry">John R. B. Perry</name><affiliation><nlm:aff id="A7"> Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, EX1 2LU, UK</nlm:aff></affiliation></author><author><name sortKey="Peters, Marjolein J" sort="Peters, Marjolein J" uniqKey="Peters M" first="Marjolein J." last="Peters">Marjolein J. Peters</name><affiliation><nlm:aff id="A21"> Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A22"> Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Preuss, Michael" sort="Preuss, Michael" uniqKey="Preuss M" first="Michael" last="Preuss">Michael Preuss</name><affiliation><nlm:aff id="A59"> Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Universitatsklinikum Schleswig-Holstein, Campus Lubeck, 23562 Lubeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Ripatti, Samuli" sort="Ripatti, Samuli" uniqKey="Ripatti S" first="Samuli" last="Ripatti">Samuli Ripatti</name><affiliation><nlm:aff id="A60"> Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A61"> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="A20"> Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A21"> Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A22"> Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Sandholt, Camilla" sort="Sandholt, Camilla" uniqKey="Sandholt C" first="Camilla" last="Sandholt">Camilla Sandholt</name><affiliation><nlm:aff id="A62"> Hagedorn Research Institute, 2820 Gentofte, Denmark</nlm:aff></affiliation></author><author><name sortKey="Scott, Laura J" sort="Scott, Laura J" uniqKey="Scott L" first="Laura J." last="Scott">Laura J. Scott</name><affiliation><nlm:aff id="A3"> Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J." last="Timpson">Nicholas J. Timpson</name><affiliation><nlm:aff id="A63"> MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, Oakfield House, Bristol, BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Tyrer, Jonathan P" sort="Tyrer, Jonathan P" uniqKey="Tyrer J" first="Jonathan P." last="Tyrer">Jonathan P. Tyrer</name><affiliation><nlm:aff id="A64"> Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Van Wingerden, Sophie" sort="Van Wingerden, Sophie" uniqKey="Van Wingerden S" first="Sophie" last="Van Wingerden">Sophie Van Wingerden</name><affiliation><nlm:aff id="A20"> Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Watanabe, Richard M" sort="Watanabe, Richard M" uniqKey="Watanabe R" first="Richard M." last="Watanabe">Richard M. Watanabe</name><affiliation><nlm:aff id="A65"> Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A66"> Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA</nlm:aff></affiliation></author><author><name sortKey="White, Charles C" sort="White, Charles C" uniqKey="White C" first="Charles C." last="White">Charles C. White</name><affiliation><nlm:aff id="A67"> Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name><affiliation><nlm:aff id="A25"> Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Barlassina, Christina" sort="Barlassina, Christina" uniqKey="Barlassina C" first="Christina" last="Barlassina">Christina Barlassina</name><affiliation><nlm:aff id="A68"> University of Milan, Department of Medicine, Surgery and Dentistry, 20139 Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name><affiliation><nlm:aff id="A69"> Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts 02215, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A70"> Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Cooper, Matthew N" sort="Cooper, Matthew N" uniqKey="Cooper M" first="Matthew N." last="Cooper">Matthew N. Cooper</name><affiliation><nlm:aff id="A71"> Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="Jansson, John Olov" sort="Jansson, John Olov" uniqKey="Jansson J" first="John-Olov" last="Jansson">John-Olov Jansson</name><affiliation><nlm:aff id="A72"> Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lawrence, Robert W" sort="Lawrence, Robert W" uniqKey="Lawrence R" first="Robert W." last="Lawrence">Robert W. Lawrence</name><affiliation><nlm:aff id="A71"> Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="Pellikka, Niina" sort="Pellikka, Niina" uniqKey="Pellikka N" first="Niina" last="Pellikka">Niina Pellikka</name><affiliation><nlm:aff id="A60"> Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A61"> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation><nlm:aff id="A8"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A9"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Shi, Jianxin" sort="Shi, Jianxin" uniqKey="Shi J" first="Jianxin" last="Shi">Jianxin Shi</name><affiliation><nlm:aff id="A4"> Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Thiering, Elisabeth" sort="Thiering, Elisabeth" uniqKey="Thiering E" first="Elisabeth" last="Thiering">Elisabeth Thiering</name><affiliation><nlm:aff id="A15"> Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Alavere, Helene" sort="Alavere, Helene" uniqKey="Alavere H" first="Helene" last="Alavere">Helene Alavere</name><affiliation><nlm:aff id="A29"> Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</nlm:aff></affiliation></author><author><name sortKey="Alibrandi, Maria T S" sort="Alibrandi, Maria T S" uniqKey="Alibrandi M" first="Maria T. S." last="Alibrandi">Maria T. S. Alibrandi</name><affiliation><nlm:aff id="A73"> University Vita-Salute San Raffaele, Division of Nephrology and Dialysis, 20132 Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Almgren, Peter" sort="Almgren, Peter" uniqKey="Almgren P" first="Peter" last="Almgren">Peter Almgren</name><affiliation><nlm:aff id="A74"> Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, 20502 Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Arnold, Alice M" sort="Arnold, Alice M" uniqKey="Arnold A" first="Alice M." last="Arnold">Alice M. Arnold</name><affiliation><nlm:aff id="A75"> Departments of Biostatistics, University of Washington, Seattle, Washington 98195, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A76"> Collaborative Health Studies Coordinating Center, Seattle, Washington 98115, USA</nlm:aff></affiliation></author><author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name><affiliation><nlm:aff id="A38"> Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A39"> University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Atwood, Larry D" sort="Atwood, Larry D" uniqKey="Atwood L" first="Larry D." last="Atwood">Larry D. Atwood</name><affiliation><nlm:aff id="A48"> Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><affiliation><nlm:aff id="A77"> INSERM CESP Centre for Research in Epidemiology and Public Health U1018, Epidemiology of diabetes, obesity and chronic kidney disease over the lifecourse, 94807 Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A78"> University Paris Sud 11, UMRS 1018, 94807 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Balmforth, Anthony J" sort="Balmforth, Anthony J" uniqKey="Balmforth A" first="Anthony J." last="Balmforth">Anthony J. Balmforth</name><affiliation><nlm:aff id="A79"> Multidisciplinary Cardiovascular Research Centre (MCRC), Leeds Institute of Genetics, Health and Therapeutics (LIGHT), University of Leeds, Leeds LS2 9JT, UK</nlm:aff></affiliation></author><author><name sortKey="Bennett, Amanda J" sort="Bennett, Amanda J" uniqKey="Bennett A" first="Amanda J." last="Bennett">Amanda J. Bennett</name><affiliation><nlm:aff id="A9"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name><affiliation><nlm:aff id="A80"> Department of Social Medicine, University of Bristol, Bristol, BS8 2PS, UK</nlm:aff></affiliation></author><author><name sortKey="Bergman, Richard N" sort="Bergman, Richard N" uniqKey="Bergman R" first="Richard N." last="Bergman">Richard N. Bergman</name><affiliation><nlm:aff id="A66"> Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA</nlm:aff></affiliation></author><author><name sortKey="Bergmann, Sven" sort="Bergmann, Sven" uniqKey="Bergmann S" first="Sven" last="Bergmann">Sven Bergmann</name><affiliation><nlm:aff id="A33"> Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A34"> Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Biebermann, Heike" sort="Biebermann, Heike" uniqKey="Biebermann H" first="Heike" last="Biebermann">Heike Biebermann</name><affiliation><nlm:aff id="A81"> Institute of Experimental Paediatric Endocrinology, Charite Universitatsmedizin Berlin, 13353 Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Blakemore, Alexandra I F" sort="Blakemore, Alexandra I F" uniqKey="Blakemore A" first="Alexandra I. F." last="Blakemore">Alexandra I. F. Blakemore</name><affiliation><nlm:aff id="A82"> Department of Genomics of Common Disease, School of Public Health, Imperial College London, W12 0NN, London, UK</nlm:aff></affiliation></author><author><name sortKey="Boes, Tanja" sort="Boes, Tanja" uniqKey="Boes T" first="Tanja" last="Boes">Tanja Boes</name><affiliation><nlm:aff id="A37"> Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, 45122 Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Bonnycastle, Lori L" sort="Bonnycastle, Lori L" uniqKey="Bonnycastle L" first="Lori L." last="Bonnycastle">Lori L. Bonnycastle</name><affiliation><nlm:aff id="A58"> National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Bornstein, Stefan R" sort="Bornstein, Stefan R" uniqKey="Bornstein S" first="Stefan R." last="Bornstein">Stefan R. Bornstein</name><affiliation><nlm:aff id="A83"> Department of Medicine III, University of Dresden, 01307 Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Brown, Morris J" sort="Brown, Morris J" uniqKey="Brown M" first="Morris J." last="Brown">Morris J. Brown</name><affiliation><nlm:aff id="A84"> Clinical Pharmacology Unit, University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Buchanan, Thomas A" sort="Buchanan, Thomas A" uniqKey="Buchanan T" first="Thomas A." last="Buchanan">Thomas A. Buchanan</name><affiliation><nlm:aff id="A66"> Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A85"> Division of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA</nlm:aff></affiliation></author><author><name sortKey="Busonero, Fabio" sort="Busonero, Fabio" uniqKey="Busonero F" first="Fabio" last="Busonero">Fabio Busonero</name><affiliation><nlm:aff id="A86"> Istituto di Neurogenetica e Neurofarmacologia del CNR, Monserrato, 09042, Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="A87"> Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</nlm:aff></affiliation></author><author><name sortKey="Cappuccio, Francesco P" sort="Cappuccio, Francesco P" uniqKey="Cappuccio F" first="Francesco P." last="Cappuccio">Francesco P. Cappuccio</name><affiliation><nlm:aff id="A88"> University of Warwick, Warwick Medical School, Coventry, CV2 2DX, UK</nlm:aff></affiliation></author><author><name sortKey="Cavalcanti Proenca, Christine" sort="Cavalcanti Proenca, Christine" uniqKey="Cavalcanti Proenca C" first="Christine" last="Cavalcanti-Proença">Christine Cavalcanti-Proença</name><affiliation><nlm:aff id="A27"> CNRS UMR8199-IBL-Institut Pasteur de Lille, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A28"> University Lille Nord de France, 59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Chen, Yii Der Ida" sort="Chen, Yii Der Ida" uniqKey="Chen Y" first="Yii-Der Ida" last="Chen">Yii-Der Ida Chen</name><affiliation><nlm:aff id="A89"> Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA</nlm:aff></affiliation></author><author><name sortKey="Chen, Chih Mei" sort="Chen, Chih Mei" uniqKey="Chen C" first="Chih-Mei" last="Chen">Chih-Mei Chen</name><affiliation><nlm:aff id="A15"> Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Chines, Peter S" sort="Chines, Peter S" uniqKey="Chines P" first="Peter S." last="Chines">Peter S. Chines</name><affiliation><nlm:aff id="A58"> National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name><affiliation><nlm:aff id="A90"> Clinical Trial Service Unit, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford, OX3 7LF, UK</nlm:aff></affiliation></author><author><name sortKey="Coin, Lachlan" sort="Coin, Lachlan" uniqKey="Coin L" first="Lachlan" last="Coin">Lachlan Coin</name><affiliation><nlm:aff id="A91"> Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Connell, John" sort="Connell, John" uniqKey="Connell J" first="John" last="Connell">John Connell</name><affiliation><nlm:aff id="A92"> University of Dundee, Ninewells Hospital & Medical School, Dundee, DD1 9SY, UK</nlm:aff></affiliation></author><author><name sortKey="Day, Ian N M" sort="Day, Ian N M" uniqKey="Day I" first="Ian N. M." last="Day">Ian N. M. Day</name><affiliation><nlm:aff id="A63"> MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, Oakfield House, Bristol, BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Den Heijer, Martin" sort="Den Heijer, Martin" uniqKey="Den Heijer M" first="Martin" last="Den Heijer">Martin Den Heijer</name><affiliation><nlm:aff id="A93"> Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A94"> Department of Endocrinology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Duan, Jubao" sort="Duan, Jubao" uniqKey="Duan J" first="Jubao" last="Duan">Jubao Duan</name><affiliation><nlm:aff id="A95"> Northshore University Healthsystem, Evanston, Ilinois 60201, USA</nlm:aff></affiliation></author><author><name sortKey="Ebrahim, Shah" sort="Ebrahim, Shah" uniqKey="Ebrahim S" first="Shah" last="Ebrahim">Shah Ebrahim</name><affiliation><nlm:aff id="A96"> The London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A97"> South Asia Network for Chronic Disease</nlm:aff></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation><nlm:aff id="A91"> Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, W2 1PG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A98"> MRC-HPA Centre for Environment and Health, London W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Elosua, Roberto" sort="Elosua, Roberto" uniqKey="Elosua R" first="Roberto" last="Elosua">Roberto Elosua</name><affiliation><nlm:aff id="A99"> Cardiovascular Epidemiology and Genetics, Institut Municipal D’investigacio Medica and CIBER Epidemiologia y Salud Publica, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation><nlm:aff id="A38"> Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation></author><author><name sortKey="Erdos, Michael R" sort="Erdos, Michael R" uniqKey="Erdos M" first="Michael R." last="Erdos">Michael R. Erdos</name><affiliation><nlm:aff id="A58"> National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G." last="Eriksson">Johan G. Eriksson</name><affiliation><nlm:aff id="A100"> Department of General Practice and Primary health Care, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A101"> National Institute for Health and Welfare, 00271 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A102"> Helsinki University Central Hospital, Unit of General Practice, 00280 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A103"> Folkhalsan Research Centre, 00250 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A104"> Vasa Central Hospital, 65130 Vasa, Finland</nlm:aff></affiliation></author><author><name sortKey="Facheris, Maurizio F" sort="Facheris, Maurizio F" uniqKey="Facheris M" first="Maurizio F." last="Facheris">Maurizio F. Facheris</name><affiliation><nlm:aff id="A105"> Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, 39100, Italy. Affiliated Institute of the University of Lubeck, Lubeck, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A106"> Department of Neurology, General Central Hospital, Bolzano, Italy</nlm:aff></affiliation></author><author><name sortKey="Felix, Stephan B" sort="Felix, Stephan B" uniqKey="Felix S" first="Stephan B." last="Felix">Stephan B. Felix</name><affiliation><nlm:aff id="A107"> Department of Internal Medicine B, Ernst-Moritz-Arndt University, 17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Fischer Posovszky, Pamela" sort="Fischer Posovszky, Pamela" uniqKey="Fischer Posovszky P" first="Pamela" last="Fischer-Posovszky">Pamela Fischer-Posovszky</name><affiliation><nlm:aff id="A108"> Pediatric Endocrinology, Diabetes and Obesity Unit, Department of Pediatrics and Adolescent Medicine, 89075 Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R." last="Folsom">Aaron R. Folsom</name><affiliation><nlm:aff id="A109"> Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis Minnesota 55454, USA</nlm:aff></affiliation></author><author><name sortKey="Friedrich, Nele" sort="Friedrich, Nele" uniqKey="Friedrich N" first="Nele" last="Friedrich">Nele Friedrich</name><affiliation><nlm:aff id="A110"> Institut fur Klinische Chemie und Laboratoriumsmedizin, Universitat Greifswald, 17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Freimer, Nelson B" sort="Freimer, Nelson B" uniqKey="Freimer N" first="Nelson B." last="Freimer">Nelson B. Freimer</name><affiliation><nlm:aff id="A111"> Center for Neurobehavioral Genetics, University of California, Los Angeles, California 90095, USA</nlm:aff></affiliation></author><author><name sortKey="Fu, Mao" sort="Fu, Mao" uniqKey="Fu M" first="Mao" last="Fu">Mao Fu</name><affiliation><nlm:aff id="A112"> Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</nlm:aff></affiliation></author><author><name sortKey="Gaget, Stefan" sort="Gaget, Stefan" uniqKey="Gaget S" first="Stefan" last="Gaget">Stefan Gaget</name><affiliation><nlm:aff id="A27"> CNRS UMR8199-IBL-Institut Pasteur de Lille, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A28"> University Lille Nord de France, 59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Gejman, Pablo V" sort="Gejman, Pablo V" uniqKey="Gejman P" first="Pablo V." last="Gejman">Pablo V. Gejman</name><affiliation><nlm:aff id="A95"> Northshore University Healthsystem, Evanston, Ilinois 60201, USA</nlm:aff></affiliation></author><author><name sortKey="Geus, Eco J C" sort="Geus, Eco J C" uniqKey="Geus E" first="Eco J. C." last="Geus">Eco J. C. Geus</name><affiliation><nlm:aff id="A50"> Department of Biological Psychology, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation><nlm:aff id="A15"> Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Gjesing, Anette P" sort="Gjesing, Anette P" uniqKey="Gjesing A" first="Anette P." last="Gjesing">Anette P. Gjesing</name><affiliation><nlm:aff id="A62"> Hagedorn Research Institute, 2820 Gentofte, Denmark</nlm:aff></affiliation></author><author><name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name><affiliation><nlm:aff id="A8"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A113"> Department of Cardiovascular Medicine, University of Oxford, Level 6 West Wing, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU</nlm:aff></affiliation></author><author><name sortKey="Goyette, Philippe" sort="Goyette, Philippe" uniqKey="Goyette P" first="Philippe" last="Goyette">Philippe Goyette</name><affiliation><nlm:aff id="A114"> Montreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada</nlm:aff></affiliation></author><author><name sortKey="Grallert, Harald" sort="Grallert, Harald" uniqKey="Grallert H" first="Harald" last="Grallert">Harald Grallert</name><affiliation><nlm:aff id="A15"> Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Gr Ler, Jurgen" sort="Gr Ler, Jurgen" uniqKey="Gr Ler J" first="Jürgen" last="Gr Ler">Jürgen Gr Ler</name><affiliation><nlm:aff id="A115"> Department of Medicine III, Pathobiochemistry, University of Dresden, 01307 Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Greenawalt, Danielle M" sort="Greenawalt, Danielle M" uniqKey="Greenawalt D" first="Danielle M." last="Greenawalt">Danielle M. Greenawalt</name><affiliation><nlm:aff id="A116"> Merck Research Laboratories, Merck & Co., Inc., Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Groves, Christopher J" sort="Groves, Christopher J" uniqKey="Groves C" first="Christopher J." last="Groves">Christopher J. Groves</name><affiliation><nlm:aff id="A9"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="A38"> Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A39"> University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Guiducci, Candace" sort="Guiducci, Candace" uniqKey="Guiducci C" first="Candace" last="Guiducci">Candace Guiducci</name><affiliation><nlm:aff id="A1"> Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation><nlm:aff id="A117"> Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Hassanali, Neelam" sort="Hassanali, Neelam" uniqKey="Hassanali N" first="Neelam" last="Hassanali">Neelam Hassanali</name><affiliation><nlm:aff id="A9"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Hall, Alistair S" sort="Hall, Alistair S" uniqKey="Hall A" first="Alistair S." last="Hall">Alistair S. Hall</name><affiliation><nlm:aff id="A79"> Multidisciplinary Cardiovascular Research Centre (MCRC), Leeds Institute of Genetics, Health and Therapeutics (LIGHT), University of Leeds, Leeds LS2 9JT, UK</nlm:aff></affiliation></author><author><name sortKey="Havulinna, Aki S" sort="Havulinna, Aki S" uniqKey="Havulinna A" first="Aki S." last="Havulinna">Aki S. Havulinna</name><affiliation><nlm:aff id="A118"> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="A119"> MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, Scotland, UK</nlm:aff></affiliation></author><author><name sortKey="Heath, Andrew C" sort="Heath, Andrew C" uniqKey="Heath A" first="Andrew C." last="Heath">Andrew C. Heath</name><affiliation><nlm:aff id="A120"> Department of Psychiatry and Midwest Alcoholism Research Center, Washington University School of Medicine, St Louis, Missouri 63108, USA</nlm:aff></affiliation></author><author><name sortKey="Hengstenberg, Christian" sort="Hengstenberg, Christian" uniqKey="Hengstenberg C" first="Christian" last="Hengstenberg">Christian Hengstenberg</name><affiliation><nlm:aff id="A121"> Klinik und Poliklinik fur Innere Medizin II, Universitat Regensburg, 93053 Regensburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A122"> Regensburg University Medical Center, Innere Medizin II, 93053 Regensburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A." last="Hicks">Andrew A. Hicks</name><affiliation><nlm:aff id="A105"> Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, 39100, Italy. Affiliated Institute of the University of Lubeck, Lubeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Hinney, Anke" sort="Hinney, Anke" uniqKey="Hinney A" first="Anke" last="Hinney">Anke Hinney</name><affiliation><nlm:aff id="A123"> Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, 45147 Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A20"> Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A22"> Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name><affiliation><nlm:aff id="A124"> Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, 17487 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Hui, Jennie" sort="Hui, Jennie" uniqKey="Hui J" first="Jennie" last="Hui">Jennie Hui</name><affiliation><nlm:aff id="A71"> Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A125"> PathWest Laboratory of Western Australia, Department of Molecular Genetics, J Block, QEII Medical Centre, Nedlands, Western Australia 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A126"> Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="Igl, Wilmar" sort="Igl, Wilmar" uniqKey="Igl W" first="Wilmar" last="Igl">Wilmar Igl</name><affiliation><nlm:aff id="A51"> Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, SE-75185 Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Iribarren, Carlos" sort="Iribarren, Carlos" uniqKey="Iribarren C" first="Carlos" last="Iribarren">Carlos Iribarren</name><affiliation><nlm:aff id="A127"> Division of Research, Kaiser Permanente Northern California, Oakland, California 94612, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A128"> Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107, USA</nlm:aff></affiliation></author><author><name sortKey="Isomaa, Bo" sort="Isomaa, Bo" uniqKey="Isomaa B" first="Bo" last="Isomaa">Bo Isomaa</name><affiliation><nlm:aff id="A103"> Folkhalsan Research Centre, 00250 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A129"> Department of Social Services and Health Care, 68601 Jakobstad, Finland</nlm:aff></affiliation></author><author><name sortKey="Jacobs, Kevin B" sort="Jacobs, Kevin B" uniqKey="Jacobs K" first="Kevin B." last="Jacobs">Kevin B. Jacobs</name><affiliation><nlm:aff id="A130"> Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA</nlm:aff></affiliation></author><author><name sortKey="Jarick, Ivonne" sort="Jarick, Ivonne" uniqKey="Jarick I" first="Ivonne" last="Jarick">Ivonne Jarick</name><affiliation><nlm:aff id="A131"> Institute of Medical Biometry and Epidemiology, University of Marburg, 35037 Marburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Jewell, Elizabeth" sort="Jewell, Elizabeth" uniqKey="Jewell E" first="Elizabeth" last="Jewell">Elizabeth Jewell</name><affiliation><nlm:aff id="A3"> Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="John, Ulrich" sort="John, Ulrich" uniqKey="John U" first="Ulrich" last="John">Ulrich John</name><affiliation><nlm:aff id="A132"> Institut fur Epidemiologie und Sozialmedizin, Universitat Greifswald, 17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="J Rgensen, Torben" sort="J Rgensen, Torben" uniqKey="J Rgensen T" first="Torben" last="J Rgensen">Torben J Rgensen</name><affiliation><nlm:aff id="A133"> Research Centre for Prevention and Health, Glostrup University Hospital, 2600 Glostrup, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A134"> Faculty of Health Science, University of Copenhagen, 2100 Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Jousilahti, Pekka" sort="Jousilahti, Pekka" uniqKey="Jousilahti P" first="Pekka" last="Jousilahti">Pekka Jousilahti</name><affiliation><nlm:aff id="A118"> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Jula, Antti" sort="Jula, Antti" uniqKey="Jula A" first="Antti" last="Jula">Antti Jula</name><affiliation><nlm:aff id="A135"> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Population Studies Unit, 20720 Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Kaakinen, Marika" sort="Kaakinen, Marika" uniqKey="Kaakinen M" first="Marika" last="Kaakinen">Marika Kaakinen</name><affiliation><nlm:aff id="A136"> Institute of Health Sciences, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A137"> Biocenter Oulu, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Kajantie, Eero" sort="Kajantie, Eero" uniqKey="Kajantie E" first="Eero" last="Kajantie">Eero Kajantie</name><affiliation><nlm:aff id="A101"> National Institute for Health and Welfare, 00271 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A138"> Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, 00029 HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Kaplan, Lee M" sort="Kaplan, Lee M" uniqKey="Kaplan L" first="Lee M." last="Kaplan">Lee M. Kaplan</name><affiliation><nlm:aff id="A2"> Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A70"> Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A139"> MGH Weight Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation></author><author><name sortKey="Kathiresan, Sekar" sort="Kathiresan, Sekar" uniqKey="Kathiresan S" first="Sekar" last="Kathiresan">Sekar Kathiresan</name><affiliation><nlm:aff id="A17"> Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A18"> Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A140"> Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A141"> Framingham Heart Study of the National, Heart, Lung, and Blood Institute and Boston University, Framingham, Massachusetts 01702, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A142"> Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Kettunen, Johannes" sort="Kettunen, Johannes" uniqKey="Kettunen J" first="Johannes" last="Kettunen">Johannes Kettunen</name><affiliation><nlm:aff id="A60"> Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A61"> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kinnunen, Leena" sort="Kinnunen, Leena" uniqKey="Kinnunen L" first="Leena" last="Kinnunen">Leena Kinnunen</name><affiliation><nlm:aff id="A143"> National Institute for Health and Welfare, Diabetes Prevention Unit, 00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Knowles, Joshua W" sort="Knowles, Joshua W" uniqKey="Knowles J" first="Joshua W." last="Knowles">Joshua W. Knowles</name><affiliation><nlm:aff id="A144"> Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA</nlm:aff></affiliation></author><author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name><affiliation><nlm:aff id="A145"> Andrija Stampar School of Public Health, Medical School, University of Zagreb, 10000 Zagreb, Croatia</nlm:aff></affiliation></author><author><name sortKey="Konig, Inke R" sort="Konig, Inke R" uniqKey="Konig I" first="Inke R." last="König">Inke R. König</name><affiliation><nlm:aff id="A59"> Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Universitatsklinikum Schleswig-Holstein, Campus Lubeck, 23562 Lubeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Koskinen, Seppo" sort="Koskinen, Seppo" uniqKey="Koskinen S" first="Seppo" last="Koskinen">Seppo Koskinen</name><affiliation><nlm:aff id="A118"> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kovacs, Peter" sort="Kovacs, Peter" uniqKey="Kovacs P" first="Peter" last="Kovacs">Peter Kovacs</name><affiliation><nlm:aff id="A146"> Interdisciplinary Centre for Clinical Research, University of Leipzig, 04103 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Kuusisto, Johanna" sort="Kuusisto, Johanna" uniqKey="Kuusisto J" first="Johanna" last="Kuusisto">Johanna Kuusisto</name><affiliation><nlm:aff id="A147"> Department of Medicine, University of Kuopio and Kuopio University Hospital, 70210 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="A23"> Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A24"> Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Kval Y, Kirsti" sort="Kval Y, Kirsti" uniqKey="Kval Y K" first="Kirsti" last="Kval Y">Kirsti Kval Y</name><affiliation><nlm:aff id="A148"> HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway</nlm:aff></affiliation></author><author><name sortKey="Laitinen, Jaana" sort="Laitinen, Jaana" uniqKey="Laitinen J" first="Jaana" last="Laitinen">Jaana Laitinen</name><affiliation><nlm:aff id="A149"> Finnish Institute of Occupational Health, 90220 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Lantieri, Olivier" sort="Lantieri, Olivier" uniqKey="Lantieri O" first="Olivier" last="Lantieri">Olivier Lantieri</name><affiliation><nlm:aff id="A150"> Institut inter-regional pour la sante (IRSA), F-37521 La Riche, France</nlm:aff></affiliation></author><author><name sortKey="Lanzani, Chiara" sort="Lanzani, Chiara" uniqKey="Lanzani C" first="Chiara" last="Lanzani">Chiara Lanzani</name><affiliation><nlm:aff id="A73"> University Vita-Salute San Raffaele, Division of Nephrology and Dialysis, 20132 Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><affiliation><nlm:aff id="A151"> Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Lecoeur, Cecile" sort="Lecoeur, Cecile" uniqKey="Lecoeur C" first="Cecile" last="Lecoeur">Cecile Lecoeur</name><affiliation><nlm:aff id="A27"> CNRS UMR8199-IBL-Institut Pasteur de Lille, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A28"> University Lille Nord de France, 59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:aff id="A152"> Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, 33520 Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Lettre, Guillaume" sort="Lettre, Guillaume" uniqKey="Lettre G" first="Guillaume" last="Lettre">Guillaume Lettre</name><affiliation><nlm:aff id="A114"> Montreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A153"> Department of Medicine, Universite de Montreal, Montreal, Quebec, H3T 1J4, Canada</nlm:aff></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:aff id="A154"> Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore</nlm:aff></affiliation></author><author><name sortKey="Lokki, Marja Liisa" sort="Lokki, Marja Liisa" uniqKey="Lokki M" first="Marja-Liisa" last="Lokki">Marja-Liisa Lokki</name><affiliation><nlm:aff id="A155"> Transplantation Laboratory, Haartman Institute, University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Lorentzon, Mattias" sort="Lorentzon, Mattias" uniqKey="Lorentzon M" first="Mattias" last="Lorentzon">Mattias Lorentzon</name><affiliation><nlm:aff id="A156"> Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Luben, Robert N" sort="Luben, Robert N" uniqKey="Luben R" first="Robert N." last="Luben">Robert N. Luben</name><affiliation><nlm:aff id="A157"> Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge CB2 2SR, UK</nlm:aff></affiliation></author><author><name sortKey="Ludwig, Barbara" sort="Ludwig, Barbara" uniqKey="Ludwig B" first="Barbara" last="Ludwig">Barbara Ludwig</name><affiliation><nlm:aff id="A83"> Department of Medicine III, University of Dresden, 01307 Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Manunta, Paolo" sort="Manunta, Paolo" uniqKey="Manunta P" first="Paolo" last="Manunta">Paolo Manunta</name><affiliation><nlm:aff id="A73"> University Vita-Salute San Raffaele, Division of Nephrology and Dialysis, 20132 Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Marek, Diana" sort="Marek, Diana" uniqKey="Marek D" first="Diana" last="Marek">Diana Marek</name><affiliation><nlm:aff id="A33"> Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A34"> Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Marre, Michel" sort="Marre, Michel" uniqKey="Marre M" first="Michel" last="Marre">Michel Marre</name><affiliation><nlm:aff id="A159"> Department of Endocrinology, Diabetology and Nutrition, Bichat-Claude Bernard University Hospital, Assistance Publique des Hopitaux de Paris, F-75018 Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A160"> Cardiovascular Genetics Research Unit, Universite Henri Poincare-Nancy 1, 54000, Nancy, France</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="A161"> Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Queensland 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L." last="Mcardle">Wendy L. Mcardle</name><affiliation><nlm:aff id="A162"> Avon Longitudinal Study of Parents and Children (ALSPAC) Laboratory, Department of Social Medicine, University of Bristol, Bristol, BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Anne" sort="Mccarthy, Anne" uniqKey="Mccarthy A" first="Anne" last="Mccarthy">Anne Mccarthy</name><affiliation><nlm:aff id="A163"> Division of Health, Research Board, An Bord Taighde Slainte, Dublin, 2, Ireland</nlm:aff></affiliation></author><author><name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name><affiliation><nlm:aff id="A75"> Departments of Biostatistics, University of Washington, Seattle, Washington 98195, USA</nlm:aff></affiliation></author><author><name sortKey="Meitinger, Thomas" sort="Meitinger, Thomas" uniqKey="Meitinger T" first="Thomas" last="Meitinger">Thomas Meitinger</name><affiliation><nlm:aff id="A164"> Institute of Human Genetics, Klinikum rechts der Isar der Technischen Universitat Munchen, 81675 Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A165"> Institute of Human Genetics, Helmholtz Zentrum Munchen - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name><affiliation><nlm:aff id="A166"> Department of Clinical Sciences, Lund University, 20502 Malmo, Sweden</nlm:aff></affiliation></author><author><name sortKey="Meyre, David" sort="Meyre, David" uniqKey="Meyre D" first="David" last="Meyre">David Meyre</name><affiliation><nlm:aff id="A27"> CNRS UMR8199-IBL-Institut Pasteur de Lille, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A28"> University Lille Nord de France, 59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Midthjell, Kristian" sort="Midthjell, Kristian" uniqKey="Midthjell K" first="Kristian" last="Midthjell">Kristian Midthjell</name><affiliation><nlm:aff id="A148"> HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway</nlm:aff></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation><nlm:aff id="A167"> Molecular Epidemiology Laboratory, Queensland Institute of Medical Research, Queensland 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Morken, Mario A" sort="Morken, Mario A" uniqKey="Morken M" first="Mario A." last="Morken">Mario A. Morken</name><affiliation><nlm:aff id="A58"> National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Morris, Andrew P" sort="Morris, Andrew P" uniqKey="Morris A" first="Andrew P." last="Morris">Andrew P. Morris</name><affiliation><nlm:aff id="A8"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Mulic, Rosanda" sort="Mulic, Rosanda" uniqKey="Mulic R" first="Rosanda" last="Mulic">Rosanda Mulic</name><affiliation><nlm:aff id="A168"> Croatian Centre for Global Health, School of Medicine, University of Split, Split 21000, Croatia</nlm:aff></affiliation></author><author><name sortKey="Ngwa, Julius S" sort="Ngwa, Julius S" uniqKey="Ngwa J" first="Julius S." last="Ngwa">Julius S. Ngwa</name><affiliation><nlm:aff id="A67"> Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Nelis, Mari" sort="Nelis, Mari" uniqKey="Nelis M" first="Mari" last="Nelis">Mari Nelis</name><affiliation><nlm:aff id="A29"> Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A30"> Estonian Biocenter, Tartu 51010, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A31"> Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Neville, Matt J" sort="Neville, Matt J" uniqKey="Neville M" first="Matt J." last="Neville">Matt J. Neville</name><affiliation><nlm:aff id="A9"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Nyholt, Dale R" sort="Nyholt, Dale R" uniqKey="Nyholt D" first="Dale R." last="Nyholt">Dale R. Nyholt</name><affiliation><nlm:aff id="A169"> Neurogenetics Laboratory, Queensland Institute of Medical Research, Queensland 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="O Onnell, Christopher J" sort="O Onnell, Christopher J" uniqKey="O Onnell C" first="Christopher J." last="O Onnell">Christopher J. O Onnell</name><affiliation><nlm:aff id="A141"> Framingham Heart Study of the National, Heart, Lung, and Blood Institute and Boston University, Framingham, Massachusetts 01702, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A170"> National, Lung, and Blood Institute, National Institutes of Health, Framingham, Massachusetts 01702, USA</nlm:aff></affiliation></author><author><name sortKey="O Ahilly, Stephen" sort="O Ahilly, Stephen" uniqKey="O Ahilly S" first="Stephen" last="O Ahilly">Stephen O Ahilly</name><affiliation><nlm:aff id="A171"> University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Ong, Ken K" sort="Ong, Ken K" uniqKey="Ong K" first="Ken K." last="Ong">Ken K. Ong</name><affiliation><nlm:aff id="A10"> MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Oostra, Ben" sort="Oostra, Ben" uniqKey="Oostra B" first="Ben" last="Oostra">Ben Oostra</name><affiliation><nlm:aff id="A172"> Department of Clinical Genetics, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Pare, Guillaume" sort="Pare, Guillaume" uniqKey="Pare G" first="Guillaume" last="Paré">Guillaume Paré</name><affiliation><nlm:aff id="A173"> Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N3Z5, Canada</nlm:aff></affiliation></author><author><name sortKey="Parker, Alex N" sort="Parker, Alex N" uniqKey="Parker A" first="Alex N." last="Parker">Alex N. Parker</name><affiliation><nlm:aff id="A174"> Amgen, Cambridge, Massachusetts 02139, USA</nlm:aff></affiliation></author><author><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name><affiliation><nlm:aff id="A60"> Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A61"> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Pichler, Irene" sort="Pichler, Irene" uniqKey="Pichler I" first="Irene" last="Pichler">Irene Pichler</name><affiliation><nlm:aff id="A105"> Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, 39100, Italy. Affiliated Institute of the University of Lubeck, Lubeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Pietil Inen, Kirsi H" sort="Pietil Inen, Kirsi H" uniqKey="Pietil Inen K" first="Kirsi H." last="Pietil Inen">Kirsi H. Pietil Inen</name><affiliation><nlm:aff id="A175"> Finnish Twin Cohort Study, Department of Public Health, University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A176"> Obesity Research unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Platou, Carl G P" sort="Platou, Carl G P" uniqKey="Platou C" first="Carl G. P." last="Platou">Carl G. P. Platou</name><affiliation><nlm:aff id="A148"> HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A177"> Department of Medicine, Levanger Hospital, The Nord-Trøndelag Health Trust, 7600 Levanger, Norway</nlm:aff></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation><nlm:aff id="A145"> Andrija Stampar School of Public Health, Medical School, University of Zagreb, 10000 Zagreb, Croatia</nlm:aff></affiliation><affiliation><nlm:aff id="A178"> Gen-Info Ltd, 10000 Zagreb, Croatia</nlm:aff></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation><nlm:aff id="A117"> Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A179"> National Institute for Health and Welfare, 90101 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Rafelt, Suzanne" sort="Rafelt, Suzanne" uniqKey="Rafelt S" first="Suzanne" last="Rafelt">Suzanne Rafelt</name><affiliation><nlm:aff id="A180"> Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, LE3 9QP, UK</nlm:aff></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation><nlm:aff id="A181"> Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520 Turku, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A182"> The Department of Clinical Physiology, Turku University Hospital, 20520 Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Rayner, Nigel W" sort="Rayner, Nigel W" uniqKey="Rayner N" first="Nigel W." last="Rayner">Nigel W. Rayner</name><affiliation><nlm:aff id="A8"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A9"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Ridderstr Le, Martin" sort="Ridderstr Le, Martin" uniqKey="Ridderstr Le M" first="Martin" last="Ridderstr Le">Martin Ridderstr Le</name><affiliation><nlm:aff id="A166"> Department of Clinical Sciences, Lund University, 20502 Malmo, Sweden</nlm:aff></affiliation></author><author><name sortKey="Rief, Winfried" sort="Rief, Winfried" uniqKey="Rief W" first="Winfried" last="Rief">Winfried Rief</name><affiliation><nlm:aff id="A183"> Clinical Psychology and Psychotherapy, University of Marburg, 35032 Marburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Ruokonen, Aimo" sort="Ruokonen, Aimo" uniqKey="Ruokonen A" first="Aimo" last="Ruokonen">Aimo Ruokonen</name><affiliation><nlm:aff id="A184"> Department of Clinical Sciences/Clinical Chemistry, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Robertson, Neil R" sort="Robertson, Neil R" uniqKey="Robertson N" first="Neil R." last="Robertson">Neil R. Robertson</name><affiliation><nlm:aff id="A8"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A9"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Rzehak, Peter" sort="Rzehak, Peter" uniqKey="Rzehak P" first="Peter" last="Rzehak">Peter Rzehak</name><affiliation><nlm:aff id="A15"> Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A185"> Ludwig-Maximilians-Universität, Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, 81377 Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation><nlm:aff id="A118"> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Sanders, Alan R" sort="Sanders, Alan R" uniqKey="Sanders A" first="Alan R." last="Sanders">Alan R. Sanders</name><affiliation><nlm:aff id="A95"> Northshore University Healthsystem, Evanston, Ilinois 60201, USA</nlm:aff></affiliation></author><author><name sortKey="Sandhu, Manjinder S" sort="Sandhu, Manjinder S" uniqKey="Sandhu M" first="Manjinder S." last="Sandhu">Manjinder S. Sandhu</name><affiliation><nlm:aff id="A10"> MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A16"> Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A157"> Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge CB2 2SR, UK</nlm:aff></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation><nlm:aff id="A86"> Istituto di Neurogenetica e Neurofarmacologia del CNR, Monserrato, 09042, Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Saramies, Jouko" sort="Saramies, Jouko" uniqKey="Saramies J" first="Jouko" last="Saramies">Jouko Saramies</name><affiliation><nlm:aff id="A186"> South Karelia Central Hospital, 53130 Lappeenranta, Finland</nlm:aff></affiliation></author><author><name sortKey="Savolainen, Markku J" sort="Savolainen, Markku J" uniqKey="Savolainen M" first="Markku J." last="Savolainen">Markku J. Savolainen</name><affiliation><nlm:aff id="A187"> Department of Clinical Sciences/Internal Medicine, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Scherag, Susann" sort="Scherag, Susann" uniqKey="Scherag S" first="Susann" last="Scherag">Susann Scherag</name><affiliation><nlm:aff id="A123"> Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, 45147 Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Schipf, Sabine" sort="Schipf, Sabine" uniqKey="Schipf S" first="Sabine" last="Schipf">Sabine Schipf</name><affiliation><nlm:aff id="A110"> Institut fur Klinische Chemie und Laboratoriumsmedizin, Universitat Greifswald, 17475 Greifswald, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A188"> Institut für Community Medicine, 17489 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Schreiber, Stefan" sort="Schreiber, Stefan" uniqKey="Schreiber S" first="Stefan" last="Schreiber">Stefan Schreiber</name><affiliation><nlm:aff id="A189"> Christian-Albrechts-University, University Hospital Schleswig-Holstein, Institute for Clinical Molecular Biology and Department of Internal Medicine I, 24105 Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Schunkert, Heribert" sort="Schunkert, Heribert" uniqKey="Schunkert H" first="Heribert" last="Schunkert">Heribert Schunkert</name><affiliation><nlm:aff id="A190"> Universität zu Lübeck, Medizinische Klinik II, 23562 Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Silander, Kaisa" sort="Silander, Kaisa" uniqKey="Silander K" first="Kaisa" last="Silander">Kaisa Silander</name><affiliation><nlm:aff id="A60"> Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A61"> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Sinisalo, Juha" sort="Sinisalo, Juha" uniqKey="Sinisalo J" first="Juha" last="Sinisalo">Juha Sinisalo</name><affiliation><nlm:aff id="A191"> Division of Cardiology, Cardiovascular Laboratory, Helsinki University Central Hospital, 00029 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S." last="Siscovick">David S. Siscovick</name><affiliation><nlm:aff id="A45"> Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A192"> Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington 98195, USA</nlm:aff></affiliation></author><author><name sortKey="Smit, Jan H" sort="Smit, Jan H" uniqKey="Smit J" first="Jan H." last="Smit">Jan H. Smit</name><affiliation><nlm:aff id="A193"> Department of Psychiatry/EMGO Institute, VU University Medical Center, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation><nlm:aff id="A16"> Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A35"> Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Sovio, Ulla" sort="Sovio, Ulla" uniqKey="Sovio U" first="Ulla" last="Sovio">Ulla Sovio</name><affiliation><nlm:aff id="A91"> Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Stephens, Jonathan" sort="Stephens, Jonathan" uniqKey="Stephens J" first="Jonathan" last="Stephens">Jonathan Stephens</name><affiliation><nlm:aff id="A194"> Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A195"> NHS Blood and Transplant, Cambridge Centre, Cambridge, CB2 0PT, UK</nlm:aff></affiliation></author><author><name sortKey="Surakka, Ida" sort="Surakka, Ida" uniqKey="Surakka I" first="Ida" last="Surakka">Ida Surakka</name><affiliation><nlm:aff id="A60"> Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A61"> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Swift, Amy J" sort="Swift, Amy J" uniqKey="Swift A" first="Amy J." last="Swift">Amy J. Swift</name><affiliation><nlm:aff id="A58"> National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Tammesoo, Mari Liis" sort="Tammesoo, Mari Liis" uniqKey="Tammesoo M" first="Mari-Liis" last="Tammesoo">Mari-Liis Tammesoo</name><affiliation><nlm:aff id="A29"> Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</nlm:aff></affiliation></author><author><name sortKey="Tardif, Jean Claude" sort="Tardif, Jean Claude" uniqKey="Tardif J" first="Jean-Claude" last="Tardif">Jean-Claude Tardif</name><affiliation><nlm:aff id="A114"> Montreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A153"> Department of Medicine, Universite de Montreal, Montreal, Quebec, H3T 1J4, Canada</nlm:aff></affiliation></author><author><name sortKey="Teder Laving, Maris" sort="Teder Laving, Maris" uniqKey="Teder Laving M" first="Maris" last="Teder-Laving">Maris Teder-Laving</name><affiliation><nlm:aff id="A30"> Estonian Biocenter, Tartu 51010, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A31"> Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Teslovich, Tanya M" sort="Teslovich, Tanya M" uniqKey="Teslovich T" first="Tanya M." last="Teslovich">Tanya M. Teslovich</name><affiliation><nlm:aff id="A3"> Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Thompson, John R" sort="Thompson, John R" uniqKey="Thompson J" first="John R." last="Thompson">John R. Thompson</name><affiliation><nlm:aff id="A196"> Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, LE3 9QP, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A197"> Department of Health Sciences, University of Leicester, University Road, Leicester, LE1 7RH, UK</nlm:aff></affiliation></author><author><name sortKey="Thomson, Brian" sort="Thomson, Brian" uniqKey="Thomson B" first="Brian" last="Thomson">Brian Thomson</name><affiliation><nlm:aff id="A1"> Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name><affiliation><nlm:aff id="A198"> Department of Medicine, University of Leipzig, 04103 Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A199"> Coordination Centre for Clinical Trials, University of Leipzig, Härtelstr. 16-18, 04103 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Tuomi, Tiinamaija" sort="Tuomi, Tiinamaija" uniqKey="Tuomi T" first="Tiinamaija" last="Tuomi">Tiinamaija Tuomi</name><affiliation><nlm:aff id="A103"> Folkhalsan Research Centre, 00250 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A200"> Department of Medicine, Helsinki University Central Hospital, 00290 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A201"> Research Program of Molecular Medicine, University of Helsinki, 00014 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Van Meurs, Joyce B J" sort="Van Meurs, Joyce B J" uniqKey="Van Meurs J" first="Joyce B. J." last="Van Meurs">Joyce B. J. Van Meurs</name><affiliation><nlm:aff id="A20"> Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A21"> Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A22"> Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Van Ommen, Gert Jan" sort="Van Ommen, Gert Jan" uniqKey="Van Ommen G" first="Gert-Jan" last="Van Ommen">Gert-Jan Van Ommen</name><affiliation><nlm:aff id="A202"> Department of Human Genetics, Leiden University Medical Center, 2333 ZC Leiden, the Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A203"> Center of Medical Systems Biology, Leiden University Medical Center, 2333 ZC Leiden, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Vatin, Vincent" sort="Vatin, Vincent" uniqKey="Vatin V" first="Vincent" last="Vatin">Vincent Vatin</name><affiliation><nlm:aff id="A27"> CNRS UMR8199-IBL-Institut Pasteur de Lille, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A28"> University Lille Nord de France, 59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Viikari, Jorma" sort="Viikari, Jorma" uniqKey="Viikari J" first="Jorma" last="Viikari">Jorma Viikari</name><affiliation><nlm:aff id="A204"> Department of Medicine, University of Turku and Turku University Hospital, 20520 Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Visvikis Siest, Sophie" sort="Visvikis Siest, Sophie" uniqKey="Visvikis Siest S" first="Sophie" last="Visvikis-Siest">Sophie Visvikis-Siest</name><affiliation><nlm:aff id="A205"> INSERM Cardiovascular Genetics team, CIC 9501, 54000 Nancy, France</nlm:aff></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation><nlm:aff id="A119"> MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, Scotland, UK</nlm:aff></affiliation></author><author><name sortKey="Vogel, Carla I G" sort="Vogel, Carla I G" uniqKey="Vogel C" first="Carla I. G." last="Vogel">Carla I. G. Vogel</name><affiliation><nlm:aff id="A123"> Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, 45147 Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Voight, Benjamin F" sort="Voight, Benjamin F" uniqKey="Voight B" first="Benjamin F." last="Voight">Benjamin F. Voight</name><affiliation><nlm:aff id="A17"> Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A18"> Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A19"> Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation></author><author><name sortKey="Waite, Lindsay L" sort="Waite, Lindsay L" uniqKey="Waite L" first="Lindsay L." last="Waite">Lindsay L. Waite</name><affiliation><nlm:aff id="A41"> Hudson Alpha Institute for Biotechnology, Huntsville, Alabama 35806, USA</nlm:aff></affiliation></author><author><name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name><affiliation><nlm:aff id="A110"> Institut fur Klinische Chemie und Laboratoriumsmedizin, Universitat Greifswald, 17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Walters, G Bragi" sort="Walters, G Bragi" uniqKey="Walters G" first="G. Bragi" last="Walters">G. Bragi Walters</name><affiliation><nlm:aff id="A6"> deCODE Genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name><affiliation><nlm:aff id="A60"> Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Wiegand, Susanna" sort="Wiegand, Susanna" uniqKey="Wiegand S" first="Susanna" last="Wiegand">Susanna Wiegand</name><affiliation><nlm:aff id="A81"> Institute of Experimental Paediatric Endocrinology, Charite Universitatsmedizin Berlin, 13353 Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name><affiliation><nlm:aff id="A87"> Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</nlm:aff></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation><nlm:aff id="A50"> Department of Biological Psychology, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Witte, Daniel R" sort="Witte, Daniel R" uniqKey="Witte D" first="Daniel R." last="Witte">Daniel R. Witte</name><affiliation><nlm:aff id="A206"> Steno Diabetes Center, 2820 Gentofte, Denmark</nlm:aff></affiliation></author><author><name sortKey="Witteman, Jacqueline C" sort="Witteman, Jacqueline C" uniqKey="Witteman J" first="Jacqueline C." last="Witteman">Jacqueline C. Witteman</name><affiliation><nlm:aff id="A20"> Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A22"> Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Xu, Jianfeng" sort="Xu, Jianfeng" uniqKey="Xu J" first="Jianfeng" last="Xu">Jianfeng Xu</name><affiliation><nlm:aff id="A207"> Center for Human Genomics, Wake Forest University, Winston-Salem, North Carolina 27157, USA</nlm:aff></affiliation></author><author><name sortKey="Zhang, Qunyuan" sort="Zhang, Qunyuan" uniqKey="Zhang Q" first="Qunyuan" last="Zhang">Qunyuan Zhang</name><affiliation><nlm:aff id="A32"> Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Zgaga, Lina" sort="Zgaga, Lina" uniqKey="Zgaga L" first="Lina" last="Zgaga">Lina Zgaga</name><affiliation><nlm:aff id="A145"> Andrija Stampar School of Public Health, Medical School, University of Zagreb, 10000 Zagreb, Croatia</nlm:aff></affiliation></author><author><name sortKey="Ziegler, Andreas" sort="Ziegler, Andreas" uniqKey="Ziegler A" first="Andreas" last="Ziegler">Andreas Ziegler</name><affiliation><nlm:aff id="A59"> Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Universitatsklinikum Schleswig-Holstein, Campus Lubeck, 23562 Lubeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Zitting, Paavo" sort="Zitting, Paavo" uniqKey="Zitting P" first="Paavo" last="Zitting">Paavo Zitting</name><affiliation><nlm:aff id="A208"> Department of Physiatrics, Lapland Central Hospital, 96101 Rovaniemi, Finland</nlm:aff></affiliation></author><author><name sortKey="Beilby, John P" sort="Beilby, John P" uniqKey="Beilby J" first="John P." last="Beilby">John P. Beilby</name><affiliation><nlm:aff id="A125"> PathWest Laboratory of Western Australia, Department of Molecular Genetics, J Block, QEII Medical Centre, Nedlands, Western Australia 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A126"> Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A209"> School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="Farooqi, I Sadaf" sort="Farooqi, I Sadaf" uniqKey="Farooqi I" first="I. Sadaf" last="Farooqi">I. Sadaf Farooqi</name><affiliation><nlm:aff id="A171"> University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Hebebrand, Johannes" sort="Hebebrand, Johannes" uniqKey="Hebebrand J" first="Johannes" last="Hebebrand">Johannes Hebebrand</name><affiliation><nlm:aff id="A123"> Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, 45147 Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Huikuri, Heikki V" sort="Huikuri, Heikki V" uniqKey="Huikuri H" first="Heikki V." last="Huikuri">Heikki V. Huikuri</name><affiliation><nlm:aff id="A210"> Department of Internal Medicine, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A210"> Department of Internal Medicine, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="James, Alan L" sort="James, Alan L" uniqKey="James A" first="Alan L." last="James">Alan L. James</name><affiliation><nlm:aff id="A126"> Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A211"> School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:aff id="A212"> Department of Clinical Physiology, University of Tampere and Tampere University Hospital, 33520 Tampere, Finland;</nlm:aff></affiliation></author><author><name sortKey="Levinson, Douglas F" sort="Levinson, Douglas F" uniqKey="Levinson D" first="Douglas F." last="Levinson">Douglas F. Levinson</name><affiliation><nlm:aff id="A213"> Stanford University School of Medicine, Stanford, California 93405, USA</nlm:aff></affiliation></author><author><name sortKey="Macciardi, Fabio" sort="Macciardi, Fabio" uniqKey="Macciardi F" first="Fabio" last="Macciardi">Fabio Macciardi</name><affiliation><nlm:aff id="A68"> University of Milan, Department of Medicine, Surgery and Dentistry, 20139 Milano, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A214"> Department of Psychiatry and Human Behavior, University of California, Irvine (UCI), Irvine, California 92617, USA</nlm:aff></affiliation></author><author><name sortKey="Nieminen, Markku S" sort="Nieminen, Markku S" uniqKey="Nieminen M" first="Markku S." last="Nieminen">Markku S. Nieminen</name><affiliation><nlm:aff id="A191"> Division of Cardiology, Cardiovascular Laboratory, Helsinki University Central Hospital, 00029 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A191"> Division of Cardiology, Cardiovascular Laboratory, Helsinki University Central Hospital, 00029 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Ohlsson, Claes" sort="Ohlsson, Claes" uniqKey="Ohlsson C" first="Claes" last="Ohlsson">Claes Ohlsson</name><affiliation><nlm:aff id="A156"> Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J." last="Palmer">Lyle J. Palmer</name><affiliation><nlm:aff id="A71"> Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A126"> Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name><affiliation><nlm:aff id="A69"> Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts 02215, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A70"> Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation><nlm:aff id="A198"> Department of Medicine, University of Leipzig, 04103 Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A215"> LIFE Study Centre, University of Leipzig, Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Jacques S" sort="Beckmann, Jacques S" uniqKey="Beckmann J" first="Jacques S." last="Beckmann">Jacques S. Beckmann</name><affiliation><nlm:aff id="A33"> Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A216"> Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, 1011 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation><nlm:aff id="A43"> Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany</nlm:aff></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation><nlm:aff id="A217"> Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:aff id="A50"> Department of Biological Psychology, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Caulfield, Mark J" sort="Caulfield, Mark J" uniqKey="Caulfield M" first="Mark J." last="Caulfield">Mark J. Caulfield</name><affiliation><nlm:aff id="A54"> Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="A4"> Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Collins, Francis S" sort="Collins, Francis S" uniqKey="Collins F" first="Francis S." last="Collins">Francis S. Collins</name><affiliation><nlm:aff id="A58"> National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Cupples, L Adrienne" sort="Cupples, L Adrienne" uniqKey="Cupples L" first="L. Adrienne" last="Cupples">L. Adrienne Cupples</name><affiliation><nlm:aff id="A67"> Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><affiliation><nlm:aff id="A63"> MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, Oakfield House, Bristol, BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Erdmann, Jeanette" sort="Erdmann, Jeanette" uniqKey="Erdmann J" first="Jeanette" last="Erdmann">Jeanette Erdmann</name><affiliation><nlm:aff id="A190"> Universität zu Lübeck, Medizinische Klinik II, 23562 Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="A27"> CNRS UMR8199-IBL-Institut Pasteur de Lille, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A28"> University Lille Nord de France, 59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A82"> Department of Genomics of Common Disease, School of Public Health, Imperial College London, W12 0NN, London, UK</nlm:aff></affiliation></author><author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name><affiliation><nlm:aff id="A25"> Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation><nlm:aff id="A51"> Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, SE-75185 Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="A25"> Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hansen, Torben" sort="Hansen, Torben" uniqKey="Hansen T" first="Torben" last="Hansen">Torben Hansen</name><affiliation><nlm:aff id="A62"> Hagedorn Research Institute, 2820 Gentofte, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A218"> Faculty of Health Science, University of Southern Denmark, 5000 Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="A151"> Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Hattersley, Andrew T" sort="Hattersley, Andrew T" uniqKey="Hattersley A" first="Andrew T." last="Hattersley">Andrew T. Hattersley</name><affiliation><nlm:aff id="A7"> Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, EX1 2LU, UK</nlm:aff></affiliation></author><author><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B." last="Hayes">Richard B. Hayes</name><affiliation><nlm:aff id="A219"> New York University Medical Center, New York, New York 10016, USA</nlm:aff></affiliation></author><author><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name><affiliation><nlm:aff id="A15"> Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B." last="Hu">Frank B. Hu</name><affiliation><nlm:aff id="A13"> Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A14"> Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A23"> Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Hveem, Kristian" sort="Hveem, Kristian" uniqKey="Hveem K" first="Kristian" last="Hveem">Kristian Hveem</name><affiliation><nlm:aff id="A148"> HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway</nlm:aff></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation><nlm:aff id="A15"> Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation><nlm:aff id="A91"> Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, W2 1PG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A136"> Institute of Health Sciences, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A137"> Biocenter Oulu, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A179"> National Institute for Health and Welfare, 90101 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation><nlm:aff id="A60"> Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A175"> Finnish Twin Cohort Study, Department of Public Health, University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A220"> National Institute for Health and Welfare, Department of Mental Health and Substance Abuse Services, Unit for Child and Adolescent Mental Health, 00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Karpe, Fredrik" sort="Karpe, Fredrik" uniqKey="Karpe F" first="Fredrik" last="Karpe">Fredrik Karpe</name><affiliation><nlm:aff id="A9"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A221"> NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:aff id="A157"> Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge CB2 2SR, UK</nlm:aff></affiliation></author><author><name sortKey="Kiemeney, Lambertus A" sort="Kiemeney, Lambertus A" uniqKey="Kiemeney L" first="Lambertus A." last="Kiemeney">Lambertus A. Kiemeney</name><affiliation><nlm:aff id="A40"> Comprehensive Cancer Center East, 6501 BG Nijmegen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A93"> Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A222"> Department of Urology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Krude, Heiko" sort="Krude, Heiko" uniqKey="Krude H" first="Heiko" last="Krude">Heiko Krude</name><affiliation><nlm:aff id="A81"> Institute of Experimental Paediatric Endocrinology, Charite Universitatsmedizin Berlin, 13353 Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Laakso, Markku" sort="Laakso, Markku" uniqKey="Laakso M" first="Markku" last="Laakso">Markku Laakso</name><affiliation><nlm:aff id="A147"> Department of Medicine, University of Kuopio and Kuopio University Hospital, 70210 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Lawlor, Debbie A" sort="Lawlor, Debbie A" uniqKey="Lawlor D" first="Debbie A." last="Lawlor">Debbie A. Lawlor</name><affiliation><nlm:aff id="A63"> MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, Oakfield House, Bristol, BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation><nlm:aff id="A29"> Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A30"> Estonian Biocenter, Tartu 51010, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A31"> Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Munroe, Patricia B" sort="Munroe, Patricia B" uniqKey="Munroe P" first="Patricia B." last="Munroe">Patricia B. Munroe</name><affiliation><nlm:aff id="A54"> Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK</nlm:aff></affiliation></author><author><name sortKey="Ouwehand, Willem H" sort="Ouwehand, Willem H" uniqKey="Ouwehand W" first="Willem H." last="Ouwehand">Willem H. Ouwehand</name><affiliation><nlm:aff id="A16"> Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A194"> Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A195"> NHS Blood and Transplant, Cambridge Centre, Cambridge, CB2 0PT, UK</nlm:aff></affiliation></author><author><name sortKey="Pedersen, Oluf" sort="Pedersen, Oluf" uniqKey="Pedersen O" first="Oluf" last="Pedersen">Oluf Pedersen</name><affiliation><nlm:aff id="A62"> Hagedorn Research Institute, 2820 Gentofte, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A223"> Institute of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A224"> Faculty of Health Science, University of Aarhus, 8000 Aarhus, Denmark</nlm:aff></affiliation></author><author><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W." last="Penninx">Brenda W. Penninx</name><affiliation><nlm:aff id="A193"> Department of Psychiatry/EMGO Institute, VU University Medical Center, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A225"> Department of Psychiatry, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A226"> Department of Psychiatry, University Medical Centre Groningen, 9713 GZ Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name><affiliation><nlm:aff id="A15"> Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><affiliation><nlm:aff id="A105"> Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, 39100, Italy. Affiliated Institute of the University of Lubeck, Lubeck, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A106"> Department of Neurology, General Central Hospital, Bolzano, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A227"> Department of Neurology, University of Lübeck, Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Quertermous, Thomas" sort="Quertermous, Thomas" uniqKey="Quertermous T" first="Thomas" last="Quertermous">Thomas Quertermous</name><affiliation><nlm:aff id="A144"> Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA</nlm:aff></affiliation></author><author><name sortKey="Reinehr, Thomas" sort="Reinehr, Thomas" uniqKey="Reinehr T" first="Thomas" last="Reinehr">Thomas Reinehr</name><affiliation><nlm:aff id="A228"> Institute for Paediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents, University of Witten-Herdecke, 45711 Datteln, Germany</nlm:aff></affiliation></author><author><name sortKey="Rissanen, Aila" sort="Rissanen, Aila" uniqKey="Rissanen A" first="Aila" last="Rissanen">Aila Rissanen</name><affiliation><nlm:aff id="A176"> Obesity Research unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="A87"> Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</nlm:aff></affiliation><affiliation><nlm:aff id="A168"> Croatian Centre for Global Health, School of Medicine, University of Split, Split 21000, Croatia</nlm:aff></affiliation></author><author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name><affiliation><nlm:aff id="A180"> Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, LE3 9QP, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A196"> Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, LE3 9QP, UK</nlm:aff></affiliation></author><author><name sortKey="Schwarz, Peter E H" sort="Schwarz, Peter E H" uniqKey="Schwarz P" first="Peter E. H." last="Schwarz">Peter E. H. Schwarz</name><affiliation><nlm:aff id="A229"> Department of Medicine III, Prevention and Care of Diabetes, University of Dresden, 01307 Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name><affiliation><nlm:aff id="A112"> Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A230"> Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, Maryland 21201, USA</nlm:aff></affiliation></author><author><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D." last="Spector">Timothy D. Spector</name><affiliation><nlm:aff id="A35"> Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Tuomilehto, Jaakko" sort="Tuomilehto, Jaakko" uniqKey="Tuomilehto J" first="Jaakko" last="Tuomilehto">Jaakko Tuomilehto</name><affiliation><nlm:aff id="A143"> National Institute for Health and Welfare, Diabetes Prevention Unit, 00271 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A231"> Hjelt Institute, Department of Public Health, University of Helsinki, 00014 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A232"> South Ostrobothnia Central Hospital, 60220 Seinajoki, Finland</nlm:aff></affiliation></author><author><name sortKey="Uda, Manuela" sort="Uda, Manuela" uniqKey="Uda M" first="Manuela" last="Uda">Manuela Uda</name><affiliation><nlm:aff id="A86"> Istituto di Neurogenetica e Neurofarmacologia del CNR, Monserrato, 09042, Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre" sort="Uitterlinden, Andre" uniqKey="Uitterlinden A" first="André" last="Uitterlinden">André Uitterlinden</name><affiliation><nlm:aff id="A20"> Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A21"> Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A22"> Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Valle, Timo T" sort="Valle, Timo T" uniqKey="Valle T" first="Timo T." last="Valle">Timo T. Valle</name><affiliation><nlm:aff id="A143"> National Institute for Health and Welfare, Diabetes Prevention Unit, 00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Wabitsch, Martin" sort="Wabitsch, Martin" uniqKey="Wabitsch M" first="Martin" last="Wabitsch">Martin Wabitsch</name><affiliation><nlm:aff id="A108"> Pediatric Endocrinology, Diabetes and Obesity Unit, Department of Pediatrics and Adolescent Medicine, 89075 Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Waeber, Gerard" sort="Waeber, Gerard" uniqKey="Waeber G" first="Gérard" last="Waeber">Gérard Waeber</name><affiliation><nlm:aff id="A233"> Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, 1011 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A10"> MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name><affiliation><nlm:aff id="A8"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A113"> Department of Cardiovascular Medicine, University of Oxford, Level 6 West Wing, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU</nlm:aff></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="A87"> Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</nlm:aff></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name><affiliation><nlm:aff id="A119"> MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, Scotland, UK</nlm:aff></affiliation></author><author><name sortKey="Zillikens, M Carola" sort="Zillikens, M Carola" uniqKey="Zillikens M" first="M. Carola" last="Zillikens">M. Carola Zillikens</name><affiliation><nlm:aff id="A21"> Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A22"> Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Chatterjee, Nilanjan" sort="Chatterjee, Nilanjan" uniqKey="Chatterjee N" first="Nilanjan" last="Chatterjee">Nilanjan Chatterjee</name><affiliation><nlm:aff id="A4"> Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Mccarroll, Steven A" sort="Mccarroll, Steven A" uniqKey="Mccarroll S" first="Steven A." last="Mccarroll">Steven A. Mccarroll</name><affiliation><nlm:aff id="A17"> Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A18"> Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A19"> Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation></author><author><name sortKey="Purcell, Shaun" sort="Purcell, Shaun" uniqKey="Purcell S" first="Shaun" last="Purcell">Shaun Purcell</name><affiliation><nlm:aff id="A17"> Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A234"> The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A235"> Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Schadt, Eric E" sort="Schadt, Eric E" uniqKey="Schadt E" first="Eric E." last="Schadt">Eric E. Schadt</name><affiliation><nlm:aff id="A236"> Pacific Biosciences, Menlo Park, California 94025, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A237"> Sage Bionetworks, Seattle, Washington 98109, USA</nlm:aff></affiliation></author><author><name sortKey="Visscher, Peter M" sort="Visscher, Peter M" uniqKey="Visscher P" first="Peter M." last="Visscher">Peter M. Visscher</name><affiliation><nlm:aff id="A26"> Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Queensland 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Assimes, Themistocles L" sort="Assimes, Themistocles L" uniqKey="Assimes T" first="Themistocles L." last="Assimes">Themistocles L. Assimes</name><affiliation><nlm:aff id="A144"> Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA</nlm:aff></affiliation></author><author><name sortKey="Borecki, Ingrid B" sort="Borecki, Ingrid B" uniqKey="Borecki I" first="Ingrid B." last="Borecki">Ingrid B. Borecki</name><affiliation><nlm:aff id="A32"> Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A238"> Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name><affiliation><nlm:aff id="A16"> Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S." last="Fox">Caroline S. Fox</name><affiliation><nlm:aff id="A239"> Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham Heart Study, Framingham, Massachusetts 01702, USA</nlm:aff></affiliation></author><author><name sortKey="Groop, Leif C" sort="Groop, Leif C" uniqKey="Groop L" first="Leif C." last="Groop">Leif C. Groop</name><affiliation><nlm:aff id="A74"> Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, 20502 Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Haritunians, Talin" sort="Haritunians, Talin" uniqKey="Haritunians T" first="Talin" last="Haritunians">Talin Haritunians</name><affiliation><nlm:aff id="A89"> Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA</nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="A13"> Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A14"> Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A23"> Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Kaplan, Robert C" sort="Kaplan, Robert C" uniqKey="Kaplan R" first="Robert C." last="Kaplan">Robert C. Kaplan</name><affiliation><nlm:aff id="A240"> Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA</nlm:aff></affiliation></author><author><name sortKey="Mohlke, Karen L" sort="Mohlke, Karen L" uniqKey="Mohlke K" first="Karen L." last="Mohlke">Karen L. Mohlke</name><affiliation><nlm:aff id="A241"> Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA</nlm:aff></affiliation></author><author><name sortKey="O Onnell, Jeffrey R" sort="O Onnell, Jeffrey R" uniqKey="O Onnell J" first="Jeffrey R." last="O Onnell">Jeffrey R. O Onnell</name><affiliation><nlm:aff id="A112"> Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</nlm:aff></affiliation></author><author><name sortKey="Peltonen, Leena" sort="Peltonen, Leena" uniqKey="Peltonen L" first="Leena" last="Peltonen">Leena Peltonen</name><affiliation><nlm:aff id="A16"> Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A60"> Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A61"> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A234"> The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A242"> Department of Medical Genetics, University of Helsinki, 00014 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Schlessinger, David" sort="Schlessinger, David" uniqKey="Schlessinger D" first="David" last="Schlessinger">David Schlessinger</name><affiliation><nlm:aff id="A243"> Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224, USA</nlm:aff></affiliation></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P." last="Strachan">David P. Strachan</name><affiliation><nlm:aff id="A244"> Division of Community Health Sciences, St George’s, University of London, London, SW17 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A20"> Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A22"> Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</nlm:aff></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H.-Erich" last="Wichmann">H.-Erich Wichmann</name><affiliation><nlm:aff id="A15"> Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A185"> Ludwig-Maximilians-Universität, Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, 81377 Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A245"> Klinikum Grosshadern, 81377 Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Frayling, Timothy M" sort="Frayling, Timothy M" uniqKey="Frayling T" first="Timothy M." last="Frayling">Timothy M. Frayling</name><affiliation><nlm:aff id="A7"> Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, EX1 2LU, UK</nlm:aff></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation><nlm:aff id="A6"> deCODE Genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A246"> Faculty of Medicine, University of Iceland, 101 Reykjavík, Iceland</nlm:aff></affiliation></author><author><name sortKey="Abecasis, Goncalo R" sort="Abecasis, Goncalo R" uniqKey="Abecasis G" first="Gonçalo R." last="Abecasis">Gonçalo R. Abecasis</name><affiliation><nlm:aff id="A3"> Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Barroso, Ines" sort="Barroso, Ines" uniqKey="Barroso I" first="Inês" last="Barroso">Inês Barroso</name><affiliation><nlm:aff id="A16"> Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A247"> University of Cambridge Metabolic Research Labs, Institute of Metabolic Science Addenbrooke’s Hospital, CB2 OQQ, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Boehnke, Michael" sort="Boehnke, Michael" uniqKey="Boehnke M" first="Michael" last="Boehnke">Michael Boehnke</name><affiliation><nlm:aff id="A3"> Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><nlm:aff id="A6"> deCODE Genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A246"> Faculty of Medicine, University of Iceland, 101 Reykjavík, Iceland</nlm:aff></affiliation></author><author><name sortKey="North, Kari E" sort="North, Kari E" uniqKey="North K" first="Kari E." last="North">Kari E. North</name><affiliation><nlm:aff id="A5"> Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A248"> Carolina Center for Genome Sciences, School of Public Health, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27514, USA</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I." last="Mccarthy">Mark I. Mccarthy</name><affiliation><nlm:aff id="A8"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A9"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A221"> NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N." last="Hirschhorn">Joel N. Hirschhorn</name><affiliation><nlm:aff id="A1"> Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A11"> Divisions of Genetics and Endocrinology and Program in Genomics, Children’s Hospital, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A249"> Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation><nlm:aff id="A25"> Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J. F." last="Loos">Ruth J. F. Loos</name><affiliation><nlm:aff id="A10"> MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Obesity is globally prevalent and highly heritable, but the underlying
genetic factors remain largely elusive. To identify genetic loci for
obesity-susceptibility, we examined associations between body mass index (BMI)
and ~2.8 million SNPs in up to 123,865 individuals, with targeted follow-up of
42 SNPs in up to 125,931 additional individuals. We confirmed 14 known
obesity-susceptibility loci and identified 18 new loci associated with BMI
(<italic>P</italic><5×10<sup>−8</sup>), one of which
includes a copy number variant near <italic>GPRC5B.</italic> Some loci
(<italic>MC4R, POMC, SH2B1, BDNF</italic>) map near key hypothalamic
regulators of energy balance, and one is near <italic>GIPR</italic>, an incretin
receptor. Furthermore, genes in other newly-associated loci may provide novel
insights into human body weight regulation.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lewis, Ce" uniqKey="Lewis C">CE Lewis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stunkard, Aj" uniqKey="Stunkard A">AJ Stunkard</name></author><author><name sortKey="Foch, Tt" uniqKey="Foch T">TT Foch</name></author><author><name sortKey="Hrubec, Z" uniqKey="Hrubec Z">Z Hrubec</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maes, Hh" uniqKey="Maes H">HH Maes</name></author><author><name sortKey="Neale, Mc" uniqKey="Neale M">MC Neale</name></author><author><name sortKey="Eaves, Lj" uniqKey="Eaves L">LJ Eaves</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, Ae" uniqKey="Taylor A">AE Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frayling, Tm" 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<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id><journal-id journal-id-type="pubmed-jr-id">2419</journal-id><journal-id journal-id-type="nlm-ta">Nat Genet</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Genet.</journal-id><journal-title-group><journal-title>Nature genetics</journal-title></journal-title-group><issn pub-type="ppub">1061-4036</issn><issn pub-type="epub">1546-1718</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20935630</article-id><article-id pub-id-type="pmc">3014648</article-id><article-id pub-id-type="doi">10.1038/ng.686</article-id><article-id pub-id-type="manuscript">NIHMS237282</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Association analyses of 249,796 individuals reveal eighteen new loci
associated with body mass index</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Speliotes</surname><given-names>Elizabeth K.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Willer</surname><given-names>Cristen J.</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Berndt</surname><given-names>Sonja I.</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Monda</surname><given-names>Keri L.</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Thorleifsson</surname><given-names>Gudmar</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Jackson</surname><given-names>Anne U.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Allen</surname><given-names>Hana Lango</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Lindgren</surname><given-names>Cecilia M.</given-names></name><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Luan</surname><given-names>Jian’an</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Mägi</surname><given-names>Reedik</given-names></name><xref ref-type="aff" 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rid="A12">12</xref><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Steinthorsdottir</surname><given-names>Valgerdur</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Stringham</surname><given-names>Heather M.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Weedon</surname><given-names>Michael N.</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Wheeler</surname><given-names>Eleanor</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Wood</surname><given-names>Andrew R.</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Ferreira</surname><given-names>Teresa</given-names></name><xref ref-type="aff" 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contrib-type="author"><name><surname>Stefansson</surname><given-names>Kari</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A246">246</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>North</surname><given-names>Kari E.</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A248">248</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>McCarthy</surname><given-names>Mark I.</given-names></name><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A9">9</xref><xref ref-type="aff" rid="A221">221</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Hirschhorn</surname><given-names>Joel N.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A11">11</xref><xref ref-type="aff" rid="A249">249</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Ingelsson</surname><given-names>Erik</given-names></name><xref ref-type="aff" rid="A25">25</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Loos</surname><given-names>Ruth J.F.</given-names></name><xref ref-type="aff" rid="A10">10</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><on-behalf-of>on behalf of Procardis Consortium</on-behalf-of></contrib-group><aff id="A1"><label>1</label> Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA</aff><aff id="A2"><label>2</label> Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</aff><aff id="A3"><label>3</label> Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA</aff><aff id="A4"><label>4</label> Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA</aff><aff id="A5"><label>5</label> Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, USA</aff><aff id="A6"><label>6</label> deCODE Genetics, 101 Reykjavik, Iceland</aff><aff id="A7"><label>7</label> Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, EX1 2LU, UK</aff><aff id="A8"><label>8</label> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</aff><aff id="A9"><label>9</label> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK</aff><aff id="A10"><label>10</label> MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK</aff><aff id="A11"><label>11</label> Divisions of Genetics and Endocrinology and Program in Genomics, Children’s Hospital, Boston, Massachusetts 02115, USA</aff><aff id="A12"><label>12</label> Regensburg University Medical Center, Department of Epidemiology and Preventive Medicine, 93053 Regensburg, Germany</aff><aff id="A13"><label>13</label> Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA</aff><aff id="A14"><label>14</label> Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA</aff><aff id="A15"><label>15</label> Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany</aff><aff id="A16"><label>16</label> Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK</aff><aff id="A17"><label>17</label> Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</aff><aff id="A18"><label>18</label> Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA</aff><aff id="A19"><label>19</label> Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</aff><aff id="A20"><label>20</label> Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands</aff><aff id="A21"><label>21</label> Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands</aff><aff id="A22"><label>22</label> Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</aff><aff id="A23"><label>23</label> Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA</aff><aff id="A24"><label>24</label> Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA</aff><aff id="A25"><label>25</label> Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</aff><aff id="A26"><label>26</label> Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Queensland 4006, Australia</aff><aff id="A27"><label>27</label> CNRS UMR8199-IBL-Institut Pasteur de Lille, F-59019 Lille, France</aff><aff id="A28"><label>28</label> University Lille Nord de France, 59000 Lille, France</aff><aff id="A29"><label>29</label> Estonian Genome Center, University of Tartu, Tartu 50410, Estonia</aff><aff id="A30"><label>30</label> Estonian Biocenter, Tartu 51010, Estonia</aff><aff id="A31"><label>31</label> Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia</aff><aff id="A32"><label>32</label> Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA</aff><aff id="A33"><label>33</label> Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland</aff><aff id="A34"><label>34</label> Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland</aff><aff id="A35"><label>35</label> Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, UK</aff><aff id="A36"><label>36</label> Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115 USA</aff><aff id="A37"><label>37</label> Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, 45122 Essen, Germany</aff><aff id="A38"><label>38</label> Icelandic Heart Association, Kopavogur, Iceland</aff><aff id="A39"><label>39</label> University of Iceland, Reykjavik, Iceland</aff><aff id="A40"><label>40</label> Comprehensive Cancer Center East, 6501 BG Nijmegen, The Netherlands</aff><aff id="A41"><label>41</label> Hudson Alpha Institute for Biotechnology, Huntsville, Alabama 35806, USA</aff><aff id="A42"><label>42</label> Department of Pharmacy and Pharmacology, University of Bath, Bath, BA1 1RL, UK</aff><aff id="A43"><label>43</label> Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany</aff><aff id="A44"><label>44</label> Department of Medicine, University of Washington, Seattle, Washington 98101, USA</aff><aff id="A45"><label>45</label> Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA</aff><aff id="A46"><label>46</label> University of Melbourne, Parkville 3010, Australia</aff><aff id="A47"><label>47</label> Department of Primary Industries, Melbourne, Victoria 3001, Australia</aff><aff id="A48"><label>48</label> Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA</aff><aff id="A49"><label>49</label> Technical University Munich, Chair of Biomathematics, Boltzmannstrasse 3, 85748 Garching</aff><aff id="A50"><label>50</label> Department of Biological Psychology, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands</aff><aff id="A51"><label>51</label> Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, SE-75185 Uppsala, Sweden</aff><aff id="A52"><label>52</label> Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, N-7489, Norway</aff><aff id="A53"><label>53</label> Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK</aff><aff id="A54"><label>54</label> Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK</aff><aff id="A55"><label>55</label> Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria</aff><aff id="A56"><label>56</label> National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK</aff><aff id="A57"><label>57</label> Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA</aff><aff id="A58"><label>58</label> National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA</aff><aff id="A59"><label>59</label> Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Universitatsklinikum Schleswig-Holstein, Campus Lubeck, 23562 Lubeck, Germany</aff><aff id="A60"><label>60</label> Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland</aff><aff id="A61"><label>61</label> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland</aff><aff id="A62"><label>62</label> Hagedorn Research Institute, 2820 Gentofte, Denmark</aff><aff id="A63"><label>63</label> MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, Oakfield House, Bristol, BS8 2BN, UK</aff><aff id="A64"><label>64</label> Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK</aff><aff id="A65"><label>65</label> Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</aff><aff id="A66"><label>66</label> Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA</aff><aff id="A67"><label>67</label> Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA</aff><aff id="A68"><label>68</label> University of Milan, Department of Medicine, Surgery and Dentistry, 20139 Milano, Italy</aff><aff id="A69"><label>69</label> Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts 02215, USA</aff><aff id="A70"><label>70</label> Harvard Medical School, Boston, Massachusetts 02115, USA</aff><aff id="A71"><label>71</label> Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia 6009, Australia</aff><aff id="A72"><label>72</label> Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden</aff><aff id="A73"><label>73</label> University Vita-Salute San Raffaele, Division of Nephrology and Dialysis, 20132 Milan, Italy</aff><aff id="A74"><label>74</label> Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, 20502 Malmö, Sweden</aff><aff id="A75"><label>75</label> Departments of Biostatistics, University of Washington, Seattle, Washington 98195, USA</aff><aff id="A76"><label>76</label> Collaborative Health Studies Coordinating Center, Seattle, Washington 98115, USA</aff><aff id="A77"><label>77</label> INSERM CESP Centre for Research in Epidemiology and Public Health U1018, Epidemiology of diabetes, obesity and chronic kidney disease over the lifecourse, 94807 Villejuif, France</aff><aff id="A78"><label>78</label> University Paris Sud 11, UMRS 1018, 94807 Villejuif, France</aff><aff id="A79"><label>79</label> Multidisciplinary Cardiovascular Research Centre (MCRC), Leeds Institute of Genetics, Health and Therapeutics (LIGHT), University of Leeds, Leeds LS2 9JT, UK</aff><aff id="A80"><label>80</label> Department of Social Medicine, University of Bristol, Bristol, BS8 2PS, UK</aff><aff id="A81"><label>81</label> Institute of Experimental Paediatric Endocrinology, Charite Universitatsmedizin Berlin, 13353 Berlin, Germany</aff><aff id="A82"><label>82</label> Department of Genomics of Common Disease, School of Public Health, Imperial College London, W12 0NN, London, UK</aff><aff id="A83"><label>83</label> Department of Medicine III, University of Dresden, 01307 Dresden, Germany</aff><aff id="A84"><label>84</label> Clinical Pharmacology Unit, University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK</aff><aff id="A85"><label>85</label> Division of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA</aff><aff id="A86"><label>86</label> Istituto di Neurogenetica e Neurofarmacologia del CNR, Monserrato, 09042, Cagliari, Italy</aff><aff id="A87"><label>87</label> Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</aff><aff id="A88"><label>88</label> University of Warwick, Warwick Medical School, Coventry, CV2 2DX, UK</aff><aff id="A89"><label>89</label> Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA</aff><aff id="A90"><label>90</label> Clinical Trial Service Unit, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford, OX3 7LF, UK</aff><aff id="A91"><label>91</label> Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, W2 1PG, UK</aff><aff id="A92"><label>92</label> University of Dundee, Ninewells Hospital & Medical School, Dundee, DD1 9SY, UK</aff><aff id="A93"><label>93</label> Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands</aff><aff id="A94"><label>94</label> Department of Endocrinology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands</aff><aff id="A95"><label>95</label> Northshore University Healthsystem, Evanston, Ilinois 60201, USA</aff><aff id="A96"><label>96</label> The London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK</aff><aff id="A97"><label>97</label> South Asia Network for Chronic Disease</aff><aff id="A98"><label>98</label> MRC-HPA Centre for Environment and Health, London W2 1PG, UK</aff><aff id="A99"><label>99</label> Cardiovascular Epidemiology and Genetics, Institut Municipal D’investigacio Medica and CIBER Epidemiologia y Salud Publica, Barcelona, Spain</aff><aff id="A100"><label>100</label> Department of General Practice and Primary health Care, University of Helsinki, Helsinki, Finland</aff><aff id="A101"><label>101</label> National Institute for Health and Welfare, 00271 Helsinki, Finland</aff><aff id="A102"><label>102</label> Helsinki University Central Hospital, Unit of General Practice, 00280 Helsinki, Finland</aff><aff id="A103"><label>103</label> Folkhalsan Research Centre, 00250 Helsinki, Finland</aff><aff id="A104"><label>104</label> Vasa Central Hospital, 65130 Vasa, Finland</aff><aff id="A105"><label>105</label> Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, 39100, Italy. Affiliated Institute of the University of Lubeck, Lubeck, Germany</aff><aff id="A106"><label>106</label> Department of Neurology, General Central Hospital, Bolzano, Italy</aff><aff id="A107"><label>107</label> Department of Internal Medicine B, Ernst-Moritz-Arndt University, 17475 Greifswald, Germany</aff><aff id="A108"><label>108</label> Pediatric Endocrinology, Diabetes and Obesity Unit, Department of Pediatrics and Adolescent Medicine, 89075 Ulm, Germany</aff><aff id="A109"><label>109</label> Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis Minnesota 55454, USA</aff><aff id="A110"><label>110</label> Institut fur Klinische Chemie und Laboratoriumsmedizin, Universitat Greifswald, 17475 Greifswald, Germany</aff><aff id="A111"><label>111</label> Center for Neurobehavioral Genetics, University of California, Los Angeles, California 90095, USA</aff><aff id="A112"><label>112</label> Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</aff><aff id="A113"><label>113</label> Department of Cardiovascular Medicine, University of Oxford, Level 6 West Wing, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU</aff><aff id="A114"><label>114</label> Montreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada</aff><aff id="A115"><label>115</label> Department of Medicine III, Pathobiochemistry, University of Dresden, 01307 Dresden, Germany</aff><aff id="A116"><label>116</label> Merck Research Laboratories, Merck & Co., Inc., Boston, Massachusetts 02115, USA</aff><aff id="A117"><label>117</label> Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, 90014 Oulu, Finland</aff><aff id="A118"><label>118</label> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, 00014, Helsinki, Finland</aff><aff id="A119"><label>119</label> MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, Scotland, UK</aff><aff id="A120"><label>120</label> Department of Psychiatry and Midwest Alcoholism Research Center, Washington University School of Medicine, St Louis, Missouri 63108, USA</aff><aff id="A121"><label>121</label> Klinik und Poliklinik fur Innere Medizin II, Universitat Regensburg, 93053 Regensburg, Germany</aff><aff id="A122"><label>122</label> Regensburg University Medical Center, Innere Medizin II, 93053 Regensburg, Germany</aff><aff id="A123"><label>123</label> Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, 45147 Essen, Germany</aff><aff id="A124"><label>124</label> Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, 17487 Greifswald, Germany</aff><aff id="A125"><label>125</label> PathWest Laboratory of Western Australia, Department of Molecular Genetics, J Block, QEII Medical Centre, Nedlands, Western Australia 6009, Australia</aff><aff id="A126"><label>126</label> Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia</aff><aff id="A127"><label>127</label> Division of Research, Kaiser Permanente Northern California, Oakland, California 94612, USA</aff><aff id="A128"><label>128</label> Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107, USA</aff><aff id="A129"><label>129</label> Department of Social Services and Health Care, 68601 Jakobstad, Finland</aff><aff id="A130"><label>130</label> Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA</aff><aff id="A131"><label>131</label> Institute of Medical Biometry and Epidemiology, University of Marburg, 35037 Marburg, Germany</aff><aff id="A132"><label>132</label> Institut fur Epidemiologie und Sozialmedizin, Universitat Greifswald, 17475 Greifswald, Germany</aff><aff id="A133"><label>133</label> Research Centre for Prevention and Health, Glostrup University Hospital, 2600 Glostrup, Denmark</aff><aff id="A134"><label>134</label> Faculty of Health Science, University of Copenhagen, 2100 Copenhagen, Denmark</aff><aff id="A135"><label>135</label> National Institute for Health and Welfare, Department of Chronic Disease Prevention, Population Studies Unit, 20720 Turku, Finland</aff><aff id="A136"><label>136</label> Institute of Health Sciences, University of Oulu, 90014 Oulu, Finland</aff><aff id="A137"><label>137</label> Biocenter Oulu, University of Oulu, 90014 Oulu, Finland</aff><aff id="A138"><label>138</label> Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, 00029 HUS, Finland</aff><aff id="A139"><label>139</label> MGH Weight Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</aff><aff id="A140"><label>140</label> Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</aff><aff id="A141"><label>141</label> Framingham Heart Study of the National, Heart, Lung, and Blood Institute and Boston University, Framingham, Massachusetts 01702, USA</aff><aff id="A142"><label>142</label> Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA</aff><aff id="A143"><label>143</label> National Institute for Health and Welfare, Diabetes Prevention Unit, 00271 Helsinki, Finland</aff><aff id="A144"><label>144</label> Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA</aff><aff id="A145"><label>145</label> Andrija Stampar School of Public Health, Medical School, University of Zagreb, 10000 Zagreb, Croatia</aff><aff id="A146"><label>146</label> Interdisciplinary Centre for Clinical Research, University of Leipzig, 04103 Leipzig, Germany</aff><aff id="A147"><label>147</label> Department of Medicine, University of Kuopio and Kuopio University Hospital, 70210 Kuopio, Finland</aff><aff id="A148"><label>148</label> HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway</aff><aff id="A149"><label>149</label> Finnish Institute of Occupational Health, 90220 Oulu, Finland</aff><aff id="A150"><label>150</label> Institut inter-regional pour la sante (IRSA), F-37521 La Riche, France</aff><aff id="A151"><label>151</label> Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA</aff><aff id="A152"><label>152</label> Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, 33520 Tampere, Finland</aff><aff id="A153"><label>153</label> Department of Medicine, Universite de Montreal, Montreal, Quebec, H3T 1J4, Canada</aff><aff id="A154"><label>154</label> Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore</aff><aff id="A155"><label>155</label> Transplantation Laboratory, Haartman Institute, University of Helsinki, 00014, Helsinki, Finland</aff><aff id="A156"><label>156</label> Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden</aff><aff id="A157"><label>157</label> Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge CB2 2SR, UK</aff><aff id="A158"><label>158</label> On behalf of the MAGIC (Meta-Analyses of Glucose and Insulin-related traits Consortium) investigators</aff><aff id="A159"><label>159</label> Department of Endocrinology, Diabetology and Nutrition, Bichat-Claude Bernard University Hospital, Assistance Publique des Hopitaux de Paris, F-75018 Paris, France</aff><aff id="A160"><label>160</label> Cardiovascular Genetics Research Unit, Universite Henri Poincare-Nancy 1, 54000, Nancy, France</aff><aff id="A161"><label>161</label> Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Queensland 4006, Australia</aff><aff id="A162"><label>162</label> Avon Longitudinal Study of Parents and Children (ALSPAC) Laboratory, Department of Social Medicine, University of Bristol, Bristol, BS8 2BN, UK</aff><aff id="A163"><label>163</label> Division of Health, Research Board, An Bord Taighde Slainte, Dublin, 2, Ireland</aff><aff id="A164"><label>164</label> Institute of Human Genetics, Klinikum rechts der Isar der Technischen Universitat Munchen, 81675 Munich, Germany</aff><aff id="A165"><label>165</label> Institute of Human Genetics, Helmholtz Zentrum Munchen - German Research Center for Environmental Health, 85764 Neuherberg, Germany</aff><aff id="A166"><label>166</label> Department of Clinical Sciences, Lund University, 20502 Malmo, Sweden</aff><aff id="A167"><label>167</label> Molecular Epidemiology Laboratory, Queensland Institute of Medical Research, Queensland 4006, Australia</aff><aff id="A168"><label>168</label> Croatian Centre for Global Health, School of Medicine, University of Split, Split 21000, Croatia</aff><aff id="A169"><label>169</label> Neurogenetics Laboratory, Queensland Institute of Medical Research, Queensland 4006, Australia</aff><aff id="A170"><label>170</label> National, Lung, and Blood Institute, National Institutes of Health, Framingham, Massachusetts 01702, USA</aff><aff id="A171"><label>171</label> University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK</aff><aff id="A172"><label>172</label> Department of Clinical Genetics, Erasmus MC, Rotterdam, 3015GE, The Netherlands</aff><aff id="A173"><label>173</label> Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N3Z5, Canada</aff><aff id="A174"><label>174</label> Amgen, Cambridge, Massachusetts 02139, USA</aff><aff id="A175"><label>175</label> Finnish Twin Cohort Study, Department of Public Health, University of Helsinki, 00014, Helsinki, Finland</aff><aff id="A176"><label>176</label> Obesity Research unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A177"><label>177</label> Department of Medicine, Levanger Hospital, The Nord-Trøndelag Health Trust, 7600 Levanger, Norway</aff><aff id="A178"><label>178</label> Gen-Info Ltd, 10000 Zagreb, Croatia</aff><aff id="A179"><label>179</label> National Institute for Health and Welfare, 90101 Oulu, Finland</aff><aff id="A180"><label>180</label> Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, LE3 9QP, UK</aff><aff id="A181"><label>181</label> Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520 Turku, Finland</aff><aff id="A182"><label>182</label> The Department of Clinical Physiology, Turku University Hospital, 20520 Turku, Finland</aff><aff id="A183"><label>183</label> Clinical Psychology and Psychotherapy, University of Marburg, 35032 Marburg, Germany</aff><aff id="A184"><label>184</label> Department of Clinical Sciences/Clinical Chemistry, University of Oulu, 90014 Oulu, Finland</aff><aff id="A185"><label>185</label> Ludwig-Maximilians-Universität, Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, 81377 Munich, Germany</aff><aff id="A186"><label>186</label> South Karelia Central Hospital, 53130 Lappeenranta, Finland</aff><aff id="A187"><label>187</label> Department of Clinical Sciences/Internal Medicine, University of Oulu, 90014 Oulu, Finland</aff><aff id="A188"><label>188</label> Institut für Community Medicine, 17489 Greifswald, Germany</aff><aff id="A189"><label>189</label> Christian-Albrechts-University, University Hospital Schleswig-Holstein, Institute for Clinical Molecular Biology and Department of Internal Medicine I, 24105 Kiel, Germany</aff><aff id="A190"><label>190</label> Universität zu Lübeck, Medizinische Klinik II, 23562 Lübeck, Germany</aff><aff id="A191"><label>191</label> Division of Cardiology, Cardiovascular Laboratory, Helsinki University Central Hospital, 00029 Helsinki, Finland</aff><aff id="A192"><label>192</label> Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington 98195, USA</aff><aff id="A193"><label>193</label> Department of Psychiatry/EMGO Institute, VU University Medical Center, 1081 BT Amsterdam, The Netherlands</aff><aff id="A194"><label>194</label> Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK</aff><aff id="A195"><label>195</label> NHS Blood and Transplant, Cambridge Centre, Cambridge, CB2 0PT, UK</aff><aff id="A196"><label>196</label> Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, LE3 9QP, UK</aff><aff id="A197"><label>197</label> Department of Health Sciences, University of Leicester, University Road, Leicester, LE1 7RH, UK</aff><aff id="A198"><label>198</label> Department of Medicine, University of Leipzig, 04103 Leipzig, Germany</aff><aff id="A199"><label>199</label> Coordination Centre for Clinical Trials, University of Leipzig, Härtelstr. 16-18, 04103 Leipzig, Germany</aff><aff id="A200"><label>200</label> Department of Medicine, Helsinki University Central Hospital, 00290 Helsinki, Finland</aff><aff id="A201"><label>201</label> Research Program of Molecular Medicine, University of Helsinki, 00014 Helsinki, Finland</aff><aff id="A202"><label>202</label> Department of Human Genetics, Leiden University Medical Center, 2333 ZC Leiden, the Netherlands</aff><aff id="A203"><label>203</label> Center of Medical Systems Biology, Leiden University Medical Center, 2333 ZC Leiden, the Netherlands</aff><aff id="A204"><label>204</label> Department of Medicine, University of Turku and Turku University Hospital, 20520 Turku, Finland</aff><aff id="A205"><label>205</label> INSERM Cardiovascular Genetics team, CIC 9501, 54000 Nancy, France</aff><aff id="A206"><label>206</label> Steno Diabetes Center, 2820 Gentofte, Denmark</aff><aff id="A207"><label>207</label> Center for Human Genomics, Wake Forest University, Winston-Salem, North Carolina 27157, USA</aff><aff id="A208"><label>208</label> Department of Physiatrics, Lapland Central Hospital, 96101 Rovaniemi, Finland</aff><aff id="A209"><label>209</label> School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia 6009, Australia</aff><aff id="A210"><label>210</label> Department of Internal Medicine, University of Oulu, 90014 Oulu, Finland</aff><aff id="A211"><label>211</label> School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6009, Australia</aff><aff id="A212"><label>212</label> Department of Clinical Physiology, University of Tampere and Tampere University Hospital, 33520 Tampere, Finland;</aff><aff id="A213"><label>213</label> Stanford University School of Medicine, Stanford, California 93405, USA</aff><aff id="A214"><label>214</label> Department of Psychiatry and Human Behavior, University of California, Irvine (UCI), Irvine, California 92617, USA</aff><aff id="A215"><label>215</label> LIFE Study Centre, University of Leipzig, Leipzig, Germany</aff><aff id="A216"><label>216</label> Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, 1011 Lausanne, Switzerland</aff><aff id="A217"><label>217</label> Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas 77030, USA</aff><aff id="A218"><label>218</label> Faculty of Health Science, University of Southern Denmark, 5000 Odense, Denmark</aff><aff id="A219"><label>219</label> New York University Medical Center, New York, New York 10016, USA</aff><aff id="A220"><label>220</label> National Institute for Health and Welfare, Department of Mental Health and Substance Abuse Services, Unit for Child and Adolescent Mental Health, 00271 Helsinki, Finland</aff><aff id="A221"><label>221</label> NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, OX3 7LJ, UK</aff><aff id="A222"><label>222</label> Department of Urology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands</aff><aff id="A223"><label>223</label> Institute of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark</aff><aff id="A224"><label>224</label> Faculty of Health Science, University of Aarhus, 8000 Aarhus, Denmark</aff><aff id="A225"><label>225</label> Department of Psychiatry, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands</aff><aff id="A226"><label>226</label> Department of Psychiatry, University Medical Centre Groningen, 9713 GZ Groningen, The Netherlands</aff><aff id="A227"><label>227</label> Department of Neurology, University of Lübeck, Lübeck, Germany</aff><aff id="A228"><label>228</label> Institute for Paediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents, University of Witten-Herdecke, 45711 Datteln, Germany</aff><aff id="A229"><label>229</label> Department of Medicine III, Prevention and Care of Diabetes, University of Dresden, 01307 Dresden, Germany</aff><aff id="A230"><label>230</label> Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, Maryland 21201, USA</aff><aff id="A231"><label>231</label> Hjelt Institute, Department of Public Health, University of Helsinki, 00014 Helsinki, Finland</aff><aff id="A232"><label>232</label> South Ostrobothnia Central Hospital, 60220 Seinajoki, Finland</aff><aff id="A233"><label>233</label> Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, 1011 Lausanne, Switzerland</aff><aff id="A234"><label>234</label> The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA</aff><aff id="A235"><label>235</label> Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115, USA</aff><aff id="A236"><label>236</label> Pacific Biosciences, Menlo Park, California 94025, USA</aff><aff id="A237"><label>237</label> Sage Bionetworks, Seattle, Washington 98109, USA</aff><aff id="A238"><label>238</label> Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110, USA</aff><aff id="A239"><label>239</label> Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham Heart Study, Framingham, Massachusetts 01702, USA</aff><aff id="A240"><label>240</label> Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA</aff><aff id="A241"><label>241</label> Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA</aff><aff id="A242"><label>242</label> Department of Medical Genetics, University of Helsinki, 00014 Helsinki, Finland</aff><aff id="A243"><label>243</label> Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224, USA</aff><aff id="A244"><label>244</label> Division of Community Health Sciences, St George’s, University of London, London, SW17 0RE, UK</aff><aff id="A245"><label>245</label> Klinikum Grosshadern, 81377 Munich, Germany</aff><aff id="A246"><label>246</label> Faculty of Medicine, University of Iceland, 101 Reykjavík, Iceland</aff><aff id="A247"><label>247</label> University of Cambridge Metabolic Research Labs, Institute of Metabolic Science Addenbrooke’s Hospital, CB2 OQQ, Cambridge, UK</aff><aff id="A248"><label>248</label> Carolina Center for Genome Sciences, School of Public Health, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27514, USA</aff><aff id="A249"><label>249</label> Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA</aff><author-notes><corresp id="FN1">Correspondence should be addressed to Michael Boehnke
(<email>boehnke@umich.edu</email>), Kari Stefansson
(<email>kstefans@decode.is</email>), Kari North
(<email>kari_north@unc.edu</email>), Mark McCarthy
(<email>mark.mccarthy@drl.ox.ac.uk</email>), Joel Hirschhorn
(<email>joelh@broadinstitute.org</email>), Erik Ingelsson
(<email>erik.ingelsson@ki.se</email>), and Ruth Loos
(<email>ruth.loos@mrc-epid.cam.ac.uk</email>)</corresp><fn id="FN2" fn-type="equal"><label>*</label><p>These authors contributed equally to this work.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>3</day><month>12</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>10</day><month>10</month><year>2010</year></pub-date><pub-date pub-type="ppub"><month>11</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>5</month><year>2011</year></pub-date><volume>42</volume><issue>11</issue><fpage>937</fpage><lpage>948</lpage><pmc-comment>elocation-id from pubmed: 10.1038/ng.686</pmc-comment>
<permissions><license><license-p>Users may view, print, copy, download and text and data- mine the content in
such documents, for the purposes of academic research, subject always to the
full Conditions of use: <ext-link ext-link-type="uri" xlink:href="http://www.nature.com/authors/editorial_policies/license.html#terms">http://www.nature.com/authors/editorial_policies/license.html#terms</ext-link></license-p></license></permissions><abstract><p id="P1">Obesity is globally prevalent and highly heritable, but the underlying
genetic factors remain largely elusive. To identify genetic loci for
obesity-susceptibility, we examined associations between body mass index (BMI)
and ~2.8 million SNPs in up to 123,865 individuals, with targeted follow-up of
42 SNPs in up to 125,931 additional individuals. We confirmed 14 known
obesity-susceptibility loci and identified 18 new loci associated with BMI
(<italic>P</italic><5×10<sup>−8</sup>), one of which
includes a copy number variant near <italic>GPRC5B.</italic> Some loci
(<italic>MC4R, POMC, SH2B1, BDNF</italic>) map near key hypothalamic
regulators of energy balance, and one is near <italic>GIPR</italic>, an incretin
receptor. Furthermore, genes in other newly-associated loci may provide novel
insights into human body weight regulation.</p></abstract></article-meta></front><body><p id="P2">Obesity is a major and increasingly prevalent risk factor for multiple disorders,
including type 2 diabetes and cardiovascular disease<xref rid="R1" ref-type="bibr">1</xref>,<xref rid="R2" ref-type="bibr">2</xref>. While lifestyle changes have
driven its prevalence to epidemic proportions, heritability studies provide evidence for
a substantial genetic contribution (h<sup>2</sup>~40–70%) to obesity
risk<xref rid="R3" ref-type="bibr">3</xref>,<xref rid="R4" ref-type="bibr">4</xref>.
BMI is an inexpensive, non-invasive measure of obesity that predicts the risk of related
complications<xref rid="R5" ref-type="bibr">5</xref>. Identifying genetic
determinants of BMI could lead to a better understanding of the biological basis of
obesity.</p><p id="P3">Genome-wide association (GWA) studies of BMI have previously identified ten loci
with genome-wide significant (<italic>P</italic> < 5×10<sup>−8</sup>)
associations in or near <italic>FTO, MC4R, TMEM18, GNPDA2, BDNF, NEGR1, SH2B1, ETV5,
MTCH2, and KCTD15</italic><xref rid="R6" ref-type="bibr">6</xref>–<xref rid="R10" ref-type="bibr">10</xref>. Many of these genes are expressed or known to
act in the central nervous system, highlighting a likely neuronal component to the
predisposition to obesity<xref rid="R9" ref-type="bibr">9</xref>. This pattern is
consistent with results in animal models and studies of monogenic human obesity, where
neuronal genes, particularly those expressed in the hypothalamus and involved in
regulation of appetite or energy balance, are known to play a major role in
susceptibility to obesity<xref rid="R11" ref-type="bibr">11</xref>–<xref rid="R13" ref-type="bibr">13</xref>.</p><p id="P4">The ten previously identified loci account for only a small fraction of the
variation in BMI. Furthermore, power calculations based on the effect sizes of
established variants have suggested that increasing the sample size would likely lead to
the discovery of additional variants<xref rid="R9" ref-type="bibr">9</xref>. To identify
more loci associated with BMI, we expanded the GIANT (Genetic Investigation of
ANtropometric Traits) consortium GWA meta-analysis to include a total of 249,769
individuals of European ancestry.</p><sec sec-type="results" id="S1"><title>Results</title><sec id="S2"><title>Stage 1 GWA studies identify novel loci associated with BMI</title><p id="P5">We first conducted a meta-analysis of GWA studies of BMI and ~2.8 million
imputed or genotyped SNPs using data from 46 studies including up to 123,865
individuals (<xref rid="SD1" ref-type="supplementary-material">Online
Methods</xref>, <xref rid="SD1" ref-type="supplementary-material">Supplementary Fig. 1</xref> and <xref rid="SD1" ref-type="supplementary-material">Supplementary Note</xref>). This stage 1
analysis revealed 19 loci associated with BMI at <italic>P</italic> <
5×10<sup>−8</sup> (<xref rid="T1" ref-type="table">Table
1</xref>, <xref rid="F1" ref-type="fig">Fig. 1a</xref> and <xref rid="SD1" ref-type="supplementary-material">Supplementary Table 1</xref>). These 19
loci included all ten loci from previous GWA studies of BMI<xref rid="R6" ref-type="bibr">6</xref>–<xref rid="R10" ref-type="bibr">10</xref>,
two loci previously associated with body weight<xref rid="R10" ref-type="bibr">10</xref> (<italic>FAIM2 and SEC16B</italic>) and one locus previously
associated with waist circumference<xref rid="R14" ref-type="bibr">14</xref>(near <italic>TFAP2B</italic>). The remaining six loci, near <italic>GPRC5B,
MAP2K5/LBXCOR1, TNNI3K, LRRN6C, FLJ35779/HMGCR, and PRKD1,</italic> have not
previously been associated with BMI or other obesity-related traits.</p></sec><sec id="S3"><title>Stage 2 follow-up leads to additional novel loci for BMI</title><p id="P6">To identify additional BMI-associated loci and to validate the loci that
reached genome-wide significance in stage 1 analyses, we examined SNPs
representing 42 independent loci (including the 19 genome-wide significant loci)
with stage 1 <italic>P</italic> < 5×10<sup>−6</sup>. Variants
were considered to be independent if the pair-wise linkage disequilibrium (LD;
<italic>r</italic><sup>2</sup>) was less than 0.1 and if they were separated
by at least 1 Mb. In stage 2, we examined these 42 SNPs in up to 125,931
additional individuals (79,561 newly genotyped individuals from 16 different
studies and 46,370 individuals from 18 additional studies for which GWA data
were available; <xref rid="T1" ref-type="table">Table 1</xref>, <xref rid="SD1" ref-type="supplementary-material">Supplementary Note</xref>, and <xref rid="SD1" ref-type="supplementary-material">Online Methods</xref>). In a
joint analysis of stage 1 and stage 2 results, 32 of the 42 SNPs reached
<italic>P</italic> < 5×10<sup>−8</sup>. Even after
excluding SNPs within these 32 confirmed BMI loci, we still observed an excess
of small <italic>P</italic>-values compared to the distribution expected under
the null hypothesis (<xref rid="F1" ref-type="fig">Fig. 1b</xref>), suggesting
that more BMI loci remain to be uncovered.</p><p id="P7">The 32 confirmed associations included all 19 loci with
<italic>P</italic> < 5×10<sup>−8</sup> at stage 1, 12
additional novel loci near <italic>RBJ/ADCY3/POMC</italic>, <italic>QPCTL/GIPR,
SLC39A8, TMEM160, FANCL, CADM2, LRP1B, PTBP2, MTIF3/GTF3A, ZNF608,
RPL27A/TUB, NUDT3/HMGA1</italic>, and one locus (<italic>NRXN3</italic>)
previously associated with waist circumference<xref rid="R15" ref-type="bibr">15</xref> (<xref rid="T1" ref-type="table">Table 1</xref>, <xref rid="SD1" ref-type="supplementary-material">Supplementary Table 1</xref>, <xref rid="SD1" ref-type="supplementary-material">Supplementary Fig. 1 and
2</xref>). In all, our study increased the number of loci robustly
associated with BMI from 10 to 32. Four of the 22 new loci were previously
associated with body weight<xref rid="R10" ref-type="bibr">10</xref> or waist
circumference<xref rid="R14" ref-type="bibr">14</xref>,<xref rid="R15" ref-type="bibr">15</xref>, whereas 18 loci had not previously associated
with any obesity-related trait in the general population. Whilst we confirmed
all loci previously established by large-scale GWA studies for BMI<xref rid="R6" ref-type="bibr">6</xref>–<xref rid="R10" ref-type="bibr">10</xref>and waist circumference<xref rid="R14" ref-type="bibr">14</xref>,<xref rid="R15" ref-type="bibr">15</xref>, four loci identified by GWA studies for
early-onset or adult morbid obesity<xref rid="R16" ref-type="bibr">16</xref>,<xref rid="R17" ref-type="bibr">17</xref> [at
<italic>NPC1</italic> (rs1805081; <italic>P</italic> = 0.0025),
<italic>MAF</italic> (rs1424233; <italic>P</italic> = 0.25),
<italic>PTER</italic> (rs10508503; <italic>P</italic> = 0.64), and
<italic>TNKS/MSRA</italic> (rs473034; <italic>P</italic> =
0.23)] showed limited or no evidence of association with BMI in our
study.</p><p id="P8">As expected, the effect sizes of the 18 newly discovered loci are
slightly smaller, for a given minor allele frequency, than those of the
previously identified variants (<xref rid="T1" ref-type="table">Table 1</xref>and <xref rid="F1" ref-type="fig">Fig. 1c</xref>). The increased sample size
also brought out more signals with low minor allele frequency. The
BMI-increasing allele frequencies for the 18 newly identified variants ranged
from 4% to 87%, covering more of the allele frequency spectrum
than previous, smaller GWA studies of BMI (24%–83%)<xref rid="R9" ref-type="bibr">9</xref>,<xref rid="R10" ref-type="bibr">10</xref>(<xref rid="T1" ref-type="table">Table 1</xref> and <xref rid="F1" ref-type="fig">Fig. 1c</xref>).</p><p id="P9">We tested for evidence of non-additive (dominant or recessive) effects,
SNP×SNP interaction effects and heterogeneity by sex or study among the
32 BMI-associated SNPs (<xref rid="SD1" ref-type="supplementary-material">Online
Methods</xref>). We found no evidence for any such effects
(<italic>P</italic> > 0.001, no significant results after correcting for
multiple testing) (<xref rid="SD1" ref-type="supplementary-material">Supplementary Tables 1</xref> and <xref rid="SD1" ref-type="supplementary-material">Supplementary Note</xref>).</p></sec><sec id="S4" sec-type="discussion"><title>Impact of 32 confirmed loci on BMI, obesity, body size, and other metabolic
traits</title><p id="P10">Together, the 32 confirmed BMI loci explained 1.45% of the
inter-individual variation in BMI of the stage 2 samples, with the
<italic>FTO</italic> SNP accounting for the largest proportion of the
variance (0.34%) (<xref rid="T1" ref-type="table">Table 1</xref>). To
estimate the cumulative effect of the 32 variants on BMI, we constructed a
genetic-susceptibility score that sums the number of BMI-increasing alleles
weighted by the overall stage 2 effect sizes in the ARIC study (N =
8,120), one of our largest population-based studies (<xref rid="SD1" ref-type="supplementary-material">Online Methods</xref>). For each unit
increase in the genetic-susceptibility score, approximately equivalent to one
additional risk allele, BMI increased by 0.17 kg/m<sup>2</sup>, equivalent to a
435–551 g gain in body weight in adults of 160–180 cm in height.
The difference in average BMI between individuals with a high
genetic-susceptibility score (≥38 BMI-increasing alleles, 1.5%
(n=124) of the ARIC sample) and those with a low genetic-susceptibility
score (≤21 BMI-increasing alleles, 2.2% (n=175) of the
ARIC sample) was 2.73 kg/m<sup>2</sup>, equivalent to a 6.99 to 8.85 kg body
weight difference in adults 160–180 cm in height (<xref rid="F2" ref-type="fig">Fig. 2a</xref>). Still, we note that the predictive value for
obesity risk and BMI of the 32 variants combined was modest, although
statistically significant (<xref rid="F2" ref-type="fig">Fig. 2b</xref>, <xref rid="SD1" ref-type="supplementary-material">Supplementary Fig. 4</xref>).
The area under the receiver operating characteristic (ROC) curve for prediction
of risk of obesity (BMI ≥ 30 kg/m<sup>2</sup>) using age,
age<sup>2</sup> and sex only was 0.515 (<italic>P</italic> = 0.023
compared to AUC of 0.50), which increased to 0.575 (<italic>P</italic> <
10<sup>−5</sup>) when also the 32 confirmed SNPs were included in
the model (<xref rid="F2" ref-type="fig">Fig. 2b</xref>). The area under the ROC
for the 32 SNPs only was 0.574 (<italic>P</italic> <
10<sup>−5</sup>).</p><p id="P11">All 32 confirmed BMI-increasing alleles showed directionally consistent
effects on risk of being overweight (BMI ≥25 kg/m<sup>2</sup>) or obese
(≥30 kg/m<sup>2</sup>) in stage 2 samples, with 30 of 32 variants
achieving at least nominally significant associations. The BMI-increasing
alleles increased the odds of overweight by 1.013 to 1.138-fold, and the odds
for being obese by 1.016- to 1.203-fold (<xref rid="SD1" ref-type="supplementary-material">Supplementary Table 2</xref>). In
addition, 30 of the 32 loci also showed directionally consistent effects on the
risk of extreme and early-onset obesity in a meta-analysis of seven case-control
studies of adults and children (binomial sign test <italic>P</italic> =
1.3×10<sup>−7</sup>) (<xref rid="SD1" ref-type="supplementary-material">Supplementary Table 3</xref>). The
BMI-increasing allele observed in adults also increased the BMI in children and
adolescents with directionally consistent effects observed for 23 of the 32 SNPs
(binomial sign test <italic>P</italic> = 0.01). Furthermore, in
family-based studies, the BMI-increasing allele was over-transmitted to the
obese offspring for 24 of the 32 SNPs (binomial sign test <italic>P</italic>= 0.004) (<xref rid="SD1" ref-type="supplementary-material">Supplementary Table 3</xref>). As these studies in extreme obesity cases,
children and families were relatively small (N<sub>range</sub> = 354
− 15,251) compared to the overall meta-analyses, their power was likely
insufficient to confirm association for all 32 loci. Nevertheless, these results
show that the effects are unlikely to reflect population stratification and that
they extend to BMI differences throughout the life course.</p><p id="P12">All BMI-increasing alleles were associated with increased body weight,
as expected from the correlation between BMI and body weight (<xref rid="SD1" ref-type="supplementary-material">Supplementary Table 2</xref>). To confirm
an effect of the loci on adiposity rather than general body size, we tested
association with body fat percentage, which was available in a subset of the
stage 2 replication samples (n = 5,359–28,425) (<xref rid="SD1" ref-type="supplementary-material">Supplementary Table 2</xref>). The
BMI-increasing allele showed directionally consistent effects on body fat
percentage at 31 of the 32 confirmed loci (binomial sign test <italic>P</italic>= 1.54×10<sup>−8</sup>) (<xref rid="SD1" ref-type="supplementary-material">Supplementary Table 2</xref>).</p><p id="P13">We also examined the association of the BMI loci with metabolic traits
(type 2 diabetes<xref rid="R18" ref-type="bibr">18</xref>, fasting glucose,
fasting insulin, indices of beta-cell function (HOMA-B) and insulin resistance
(HOMA-IR)<xref rid="R19" ref-type="bibr">19</xref>, and blood lipid
levels<xref rid="R20" ref-type="bibr">20</xref>) and with height (<xref rid="SD1" ref-type="supplementary-material">Supplementary Tables 2 and
4</xref>). Although many nominal associations are expected because of known
correlations between BMI and most of these traits and because of overlap in
samples, several associations stand out as possible examples of pleiotropic
effects of the BMI-associated variants. Particularly interesting is the variant
in the <italic>GIPR</italic> locus where the BMI-increasing allele is also
associated with increased fasting glucose levels and lower 2-hour glucose levels
(<xref rid="SD1" ref-type="supplementary-material">Supplementary Table
4</xref>)<xref rid="R19" ref-type="bibr">19</xref>,<xref rid="R21" ref-type="bibr">21</xref>. The direction of the effect is opposite to what
would be expected due to the correlation between obesity and glucose
intolerance, but is consistent with the suggested roles of <italic>GIPR</italic>in glucose and energy metabolism (see below)<xref rid="R22" ref-type="bibr">22</xref>. Three loci show strong associations (<italic>P</italic> <
10<sup>−4</sup>) with height (<italic>MC4R</italic>,
<italic>RBJ/ADCY3/POMC</italic> and <italic>MTCH2/NDUFS3</italic>). Because
BMI is weakly correlated with height (and indeed, the BMI-associated variants as
a group show no consistent effect on height), these associations are also
suggestive of pleiotropy. Interestingly, analogous to the effects of severe
mutations in <italic>POMC</italic> and <italic>MC4R</italic> on height and
weight<xref rid="R23" ref-type="bibr">23</xref>,<xref rid="R24" ref-type="bibr">24</xref>, the BMI-increasing alleles of the variants near
these genes were associated with decreased (<italic>POMC</italic>) and increased
(<italic>MC4R</italic>) height, respectively (<xref rid="SD1" ref-type="supplementary-material">Supplementary Table 2</xref>).</p></sec><sec id="S5"><title>Potential functional roles and pathways analyses</title><p id="P14">Although associated variants typically implicate genomic regions rather
than individual genes, we note that some of the 32 loci include candidate genes
with established connections to obesity. Several of the 10 previously identified
loci are located in or near genes that encode neuronal regulators of appetite or
energy balance, including <italic>MC4R</italic><xref rid="R12" ref-type="bibr">12</xref>,<xref rid="R25" ref-type="bibr">25</xref>,
<italic>BDNF</italic><xref rid="R26" ref-type="bibr">26</xref>, and
<italic>SH2B1</italic><xref rid="R11" ref-type="bibr">11</xref>,<xref rid="R27" ref-type="bibr">27</xref>. Each of these genes has been tied to
obesity, not only in animal models, but also by rare human variants that disrupt
each of these genes and lead to severe obesity<xref rid="R24" ref-type="bibr">24</xref>,<xref rid="R28" ref-type="bibr">28</xref>,<xref rid="R29" ref-type="bibr">29</xref>. Using the automated literature search programme,
Snipper (<xref rid="SD1" ref-type="supplementary-material">Online
Methods</xref>), we identified various genes within the novel loci with
potential biological links to obesity-susceptibility (<xref rid="SD1" ref-type="supplementary-material">Supplementary Note</xref>). Among the
novel loci, the location of rs713586 near <italic>POMC</italic> provides further
support for a role of neuroendocrine circuits that regulate energy balance in
susceptibility to obesity. <italic>POMC</italic> encodes several polypeptides
including α-MSH, a ligand of the <italic>MC4R</italic> gene product<xref rid="R30" ref-type="bibr">30</xref>, and rare mutations in
<italic>POMC</italic> also cause human obesity<xref rid="R23" ref-type="bibr">23</xref>,<xref rid="R29" ref-type="bibr">29</xref>,<xref rid="R31" ref-type="bibr">31</xref>.</p><p id="P15">In contrast, the locus near <italic>GIPR,</italic> which encodes a
receptor of gastric inhibitory polypeptide (GIP), suggests a role for peripheral
biology in obesity. GIP, which is expressed in the K cell of the duodenum and
intestine, is an incretin hormone that mediates incremental insulin secretion in
response to oral intake of glucose. The variant associated with BMI is in strong
LD (<italic>r</italic><sup>2</sup> = 0.83) with a missense SNP in
<italic>GIPR</italic> (rs1800437, Glu354Gln) that has recently been shown to
influence the glucose and insulin response to an oral glucose challenge <xref rid="R21" ref-type="bibr">21</xref>. Although no human phenotype is known to
be caused by mutations in <italic>GIPR</italic>, mice with disruption of
<italic>Gipr</italic> are resistant to diet-induced obesity<xref rid="R32" ref-type="bibr">32</xref>. The association of a variant in
<italic>GIPR</italic> with BMI suggests that there may be a link between
incretins/insulin secretion and body weight regulation in humans as well.</p><p id="P16">To systematically identify biological connections among the genes
located near the 32 confirmed SNPs, and to potentially identify new pathways
associated with BMI, we performed pathway-based analyses using MAGENTA<xref rid="R33" ref-type="bibr">33</xref>. Specifically, we tested for enrichment
of BMI genetic associations in biological processes or molecular functions that
contain at least one gene from the 32 confirmed BMI loci (<xref rid="SD1" ref-type="supplementary-material">Online Methods</xref>). Using annotations
from the KEGG, Ingenuity, PANTHER, and Gene Ontology databases, we found
evidence of enrichment for pathways involved in the platelet-derived growth
factor (PDGF) signaling (PANTHER, P = 0.0008, FDR = 0.0061),
translation elongation (PANTHER, P = 0.0008, FDR = 0.0066),
hormone or nuclear hormone receptor binding (Gene Ontology, P < 0.0005, FDR
< 0.0085), homeobox transcription (PANTHER, P = 0.0001, FDR =
0.011), regulation of cellular metabolism (Gene Ontology, P = 0.0002,
FDR = 0.031), neurogenesis and neuron differentiation (Gene Ontology, P
< 0.0002, FDR < 0.034), protein phosphorylation (PANTHER, P =
0.0001, FDR = 0.045) and numerous other pathways related to growth,
metabolism, immune and neuronal processes (Gene Ontology, P < 0.002, FDR <
0.046) (<xref rid="SD1" ref-type="supplementary-material">Supplementary Table
5</xref>).</p></sec><sec id="S6"><title>Identifying possible functional variants</title><p id="P17">We used data from the 1000 Genomes Project and the HapMap Consortium to
explore whether the 32 confirmed BMI SNPs were in LD
(<italic>r</italic><sup>2</sup> ≥ 0.75) with common missense SNPs or
copy number variants (CNVs) (<xref rid="SD1" ref-type="supplementary-material">Online Methods</xref>). Non-synonymous variants in LD with our signals were
present in the <italic>BDNF, SLC39A8, FLJ35779/HMGCR, QPCTL/GIPR, MTCH2,
ADCY3,</italic> and <italic>LBXCOR1</italic> genes. In addition, the
rs7359397 signal was in LD with coding variants in several genes including
<italic>SH2B1, ATNX2L, APOB48R, SULT1A2,</italic> and
<italic>AC138894.2</italic> (<xref rid="T1" ref-type="table">Table 1</xref>,
<xref rid="F3" ref-type="fig">Fig. 3</xref>, <xref rid="SD1" ref-type="supplementary-material">Supplementary Table 6</xref> and <xref rid="SD1" ref-type="supplementary-material">Supplementary Fig. 2</xref>).
Furthermore, two SNPs tagged common CNVs. The first CNV was previously
identified and is a 45-kb deletion near <italic>NEGR1</italic><xref rid="R9" ref-type="bibr">9</xref>. The second CNV is a 21-kb deletion that lies 50kb
upstream of <italic>GPRC5B;</italic> the deletion allele is tagged by the
T-allele of rs12444979 (<italic>r</italic><sup>2</sup> = 1) (<xref rid="F3" ref-type="fig">Fig. 3</xref>). Although the correlations with
potentially functional variants does not prove that these variants are indeed
causal, these provide first clues as to which genes and variants at these loci
might be prioritized for fine-mapping and functional follow-up.</p><p id="P18">As many of the 32 BMI loci harbor multiple genes, we examined whether
gene expression (eQTL) analyses could also direct us to positional candidates.
Gene expression data were available for human brain, lymphocytes, blood,
subcutaneous and visceral adipose tissue, and liver<xref rid="R34" ref-type="bibr">34</xref>–<xref rid="R36" ref-type="bibr">36</xref>(<xref rid="SD1" ref-type="supplementary-material">Online Methods</xref>,
<xref rid="T1" ref-type="table">Table 1</xref> and <xref rid="SD1" ref-type="supplementary-material">Supplementary Table 7</xref>). Significant
<italic>cis</italic>-associations, defined at the tissue-specific level,
were observed between 14 BMI-associated alleles and expression levels (<xref rid="T1" ref-type="table">Table 1</xref> and <xref rid="SD1" ref-type="supplementary-material">Supplementary Table 7</xref>). In several
cases, the BMI-associated SNP was the most significant SNP or explained a
substantial proportion of the association with the most significant SNP for the
gene transcript in conditional analyses
(<italic>P</italic><sub>adj</sub>>0.05). These significant associations
included <italic>NEGR1, ZC3H4</italic>, <italic>TMEM160</italic>,
<italic>MTCH2</italic>, <italic>NDUFS3</italic>, <italic>GTF3A,
ADCY3</italic>, <italic>APOB48R</italic>, <italic>SH2B1</italic>,
<italic>TUFM</italic>, <italic>GPRC5B</italic>, <italic>IQCK</italic>,
<italic>SLC39A8</italic>, <italic>SULT1A1</italic>, and
<italic>SULT1A2</italic> (<xref rid="T1" ref-type="table">Table 1</xref> and
<xref rid="SD1" ref-type="supplementary-material">Supplementary Table
7</xref>), making these genes higher priority candidates within the
associated loci. However, we note that some BMI-associated variants were
correlated with the expression of multiple nearby genes, making it difficult to
determine the most relevant gene.</p></sec><sec id="S7"><title>Evidence for the existence of additional associated variants</title><p id="P19">Because the variants identified by this large study explain only
1.45% of the variance in BMI (2–4% of genetic variance
based on an estimated heritability of 40–70%), we considered how
much the explained phenotypic variance could be increased by including more SNPs
at various degrees of significance in a polygene model using an independent
validation set (<xref rid="SD1" ref-type="supplementary-material">Online
Methods</xref>)<xref rid="R37" ref-type="bibr">37</xref>. We found that
including SNPs associated with BMI at lower significance levels (up to
<italic>P</italic> > 0.05) increased the explained phenotypic variance in
BMI to 2.5%, or 4% to 6% of genetic variance (<xref rid="F4" ref-type="fig">Fig. 4a</xref>). In a separate analysis, we
estimated the total number of independent BMI-associated variants that are
likely to exist with similar effect sizes to the 32 confirmed here (<xref rid="SD1" ref-type="supplementary-material">Online Methods</xref>)<xref rid="R38" ref-type="bibr">38</xref>. Based on the effect size and allele
frequencies of the 32 replicated loci observed in stage 2 and the power to
detect association in the combined stage 1 and stage 2, we estimated that there
are 284 (95% CI: 132–510) loci with similar effect sizes as the
currently observed ones, which together would account for 4.5%
(95% CI: 3.1–6.8%) of the variation in BMI or
6–11% of the genetic variation (based on an estimated
heritability of 40–70%) (<xref rid="SD1" ref-type="supplementary-material">Supplementary Table 8</xref>). In order to
detect 95% of these loci, a sample size of approximately 730,000
subjects would be needed (<xref rid="F4" ref-type="fig">Fig. 4b</xref>). This
method does not account for the potential of loci of smaller effect than those
identified here to explain even more of the variance and thus provides an
estimated lower bound of explained variance. These two analyses strongly suggest
that larger GWA studies will continue to identify additional novel associated
loci, but also indicate that even extremely large studies focusing on variants
with allele frequencies above 5% will not account for a large fraction
of the genetic contribution to BMI.</p><p id="P20">We examined whether selecting only a single variant from each locus for
follow-up led us to underestimate the fraction of phenotypic variation explained
by the associated loci. To search for additional independent loci at each of the
32 associated BMI loci, we repeated our GWA meta-analysis, conditioning on the
32 confirmed SNPs. Using a significance threshold of 5 ×
10<sup>−6</sup> for SNPs at known loci, we identified one apparently
independent signal at the <italic>MC4R</italic> locus; rs7227255 was associated
with BMI (<italic>P</italic> = 6.56 × 10<sup>−7</sup>)
even after conditioning for the most strongly associated variant near
<italic>MC4R</italic> (rs571312) (<xref rid="F5" ref-type="fig">Fig.
5</xref>). Interestingly, rs7227255 is in perfect LD (r<sup>2</sup>= 1) with a relatively rare <italic>MC4R</italic> missense variant
(rs2229616, V103I, minor allele frequency = 1.7%) that has been
associated with BMI in two independent meta-analyses<xref rid="R39" ref-type="bibr">39</xref>,<xref rid="R40" ref-type="bibr">40</xref>.
Furthermore, mutations at the <italic>MC4R</italic> locus are known to influence
early-onset obesity<xref rid="R24" ref-type="bibr">24</xref>,<xref rid="R41" ref-type="bibr">41</xref>, supporting the notion that allelic heterogeneity
may be a frequent phenomenon in the genetic architecture of obesity.</p></sec></sec><sec sec-type="discussion" id="S8"><title>Discussion</title><p id="P21">Using a two-stage genome-wide association meta-analysis of up to 249,796
individuals of European descent, we have identified 18 additional loci that are
associated with BMI at genome-wide significance, bringing the total number of such
loci to 32. We estimate that more than 250 (i.e. 284 predicted loci – 32
confirmed loci) common variant loci with effects on BMI similar to those described
here remain to be discovered, and even larger numbers of loci with smaller effects.
A substantial proportion of these loci should be identifiable through larger GWA
studies and/or by targeted follow-up of top signals selected from our stage 1
analysis. The latter approach is already being implemented through large-scale
genotyping of samples informative for BMI using a custom array (the Metabochip)
designed to support follow-up of thousands of promising variants in hundreds of
thousands of individuals.</p><p id="P22">The combined effect on BMI of the associated variants at the 32 loci is
modest, and even when we try to account for as-yet-undiscovered variants with
similar properties, we estimate that these common variant signals account for only
6–11% of the genetic variation in BMI. There is a strong expectation
that additional variance and biology will be explained using complementary
approaches that capture variants not examined in the current study, such as lower
frequency variants and short insertion-deletion polymorphisms. There is good reason
to believe (based on our findings at <italic>MC4R</italic> and other loci
<italic>– POMC, BDNF, SH2B1 –</italic> which feature both common
and rare variant associations) that a proportion of such low-frequency and rare
causal variation will map to the loci already identified by GWA studies.</p><p id="P23">A primary goal of human genetic discovery is to improve understanding of the
biology of conditions such as obesity<xref rid="R42" ref-type="bibr">42</xref>. One
particularly interesting finding in this regard is the association between BMI and
common variants near <italic>GIPR</italic>, which may indicate a causal contribution
of variation in postprandial insulin secretion to the development of obesity. In
most cases, the loci identified by the present study harbor few, if any, annotated
genes with clear connections to the biology of weight regulation. This reflects our
still limited understanding of the biology of BMI and obesity-related traits and is
in striking contrast with the results from equivalent studies of certain other
traits (such as autoimmune diseases or lipid levels). Thus, these results suggest
that much novel biology remains to be uncovered, and that GWA studies may provide an
important entry point. In particular, further examination of the associated loci
through a combination of resequencing and fine-mapping to find causal variants, and
genomic and experimental studies designed to assign function, could uncover novel
insights into the biology of obesity.</p><p id="P24">In conclusion, we have performed GWA studies in large samples to identify
numerous genetic loci associated with variation in BMI, a common measure of obesity.
Because current lifestyle interventions are largely ineffective in addressing the
challenges of growing obesity<xref rid="R43" ref-type="bibr">43</xref>,<xref rid="R44" ref-type="bibr">44</xref>, new insights into biology are critically
needed to guide the development and application of future therapies and
interventions.</p></sec><sec sec-type="supplementary-material" id="S9"><title>Supplementary Material</title><supplementary-material content-type="local-data" id="SD1"><label>1</label><caption><p id="P25"><bold>Supplementary Figure 1 Study design.</bold> Stage 1 - Meta
analysis of genome-wide association data was performed in stage 1 across 46
studies of white European Ancestry. A total of 42 SNPs representing the best
associating (<italic>P</italic> < 10<sup>−6</sup>) loci (shown)
were taken forward for replication. Nineteen of these SNPs (loci in bold)
reached already genome-wide significance at stage 1. Stage 2 – The
42 SNPs were genotyped in 16 de novo replication studies and extracted from
18 <italic>in silico</italic> replication studies, all adults of European
ancestry and were tested for association with BMI. In a joint analyses of
stage 1 and stage 2 data, 32 SNPs (loci in bold) reached genome-wide
significance (<italic>P</italic> < 5×10<sup>−8</sup>).
Follow-up analyses – The 32 confirmed loci were taken forward for
additional analyses.</p><p id="P26"><bold>Supplementary Figure 2 Regional plots of the 32 confirmed BMI
loci with missense and CNV variants.</bold> SNPs are plotted by position
on chromosome against association with BMI (−log<sub>10</sub><italic>P</italic>-value). The SNP name shown on the plot was the most
significant SNP after stage 1 meta-analysis. Estimated recombination rates
(from HapMap) are plotted in cyan to reflect the local LD structure. The
SNPs surrounding the most significant SNP are color-coded to reflect their
LD with this SNP (taken from pairwise r<sup>2</sup> values from the HapMap
CEU database, <ext-link ext-link-type="uri" xlink:href="www.hapmap.org">www.hapmap.org</ext-link>). Genes, position of exons, and direction of
transcription from UCSC genome browser (genome.ucsc.edu) are noted.
Hash-marks represent SNP positions available in the meta-analysis. Plots
were generated using LocusZoom (<ext-link ext-link-type="uri" xlink:href="http://csg.sph.umich.edu/locuszoom">http://csg.sph.umich.edu/locuszoom</ext-link>).</p><p id="P27"><bold>Supplementary Figure 3</bold> Quantile-quantile plot of SNPs
at stage 1 GIANT meta-analysis (black) and after removing any SNPs within 1
Mb of the 10 previously reported genome-wide significant hits for BMI
(blue), after additionally excluding the four loci for waist/weight (green)
and after excluding all 32 confirmed loci (red).</p><p id="P28"><bold>Supplementary Figure 4</bold> Relationship between the
predicted BMI, based on the 32 confirmed BMI loci combined, and the actual
BMI in the ARIC Study (N=8,120). Panel (<bold>a</bold>) shows the
comparison of the predicted BMI (grey), with the actual BMI (green) and
quartile ranges (orange) in sets of 500 individuals, suggesting good average
predictions. Panel (<bold>b</bold>) shows the comparison of the individual
predicted and observed BMI values, suggesting poor individual
predictions.</p><p id="P29"><bold>Supplementary Table 1</bold> The 42 SNPs, associated with BMI
at <italic>P</italic> < 5.10<sup>−6</sup> at stage 1, that were
taken forward for replication in stage 2.</p><p id="P30"><bold>Supplementary Table 2</bold> Association of 32 replicated SNPs
with other anthropometric traits.</p><p id="P31"><bold>Supplementary Table 3</bold> Association between 32 replicated
SNPs with risk of extreme obesity in children and adults, and with BMI in
population-based childhood studies.</p><p id="P32"><bold>Supplementary Table 4</bold> Association of the 32 confirmed
BMI SNPs with metabolic traits.</p><p id="P33"><bold>Supplementary Table 5</bold> Gene set enrichment analysis
(MAGENTA) of biological pathways with one or more genes from the 32
confirmed BMI loci, using the BMI meta-analysis.</p><p id="P34"><bold>Supplementary Table 6</bold> Non-synonymous or splice-site
variants in linkage disequilibrium (r<sup>2</sup> > 0.75) with lead
SNPs.</p><p id="P35"><bold>Supplementary Table 7</bold> Significant associations between
BMI SNPs and <italic>cis</italic> gene expression
(<italic>cis</italic>-eQTLs) in lymphocyte, blood, adipose and brain
tissues.</p><p id="P36"><bold>Supplementary Table 8</bold> Estimated number of BMI loci for
each of the effect sizes observed in Stage 2 for the SNPs that reached a
genome-wide significance of 5×10<sup>−8</sup> in the joint
analysis of stage 1 and stage 2, given the power to detect the association
in the joint analysis of stage 1 and stage 2.</p></caption><media xlink:href="NIHMS237282-supplement-1.pdf" mimetype="application" mime-subtype="pdf" xlink:type="simple" id="d37e5439" position="anchor"></media></supplementary-material></sec></body><back><ack id="S11"><p>A full list of acknowledgments appears in the <xref rid="SD1" ref-type="supplementary-material">Supplementary Note</xref>.</p><p>Academy of Finland (10404, 77299, 104781, 114382, 117797, 120315, 121584, 124243,
126775, 126925, 127437, 129255, 129269, 129306, 129494, 129680, 130326, 209072,
210595, 213225, 213506, 216374); ADA Mentor-Based Postdoctoral Fellowship; Amgen;
Agency for Science, Technology and Research of Singapore (A*STAR); ALF/LUA
research grant in Gothenburg; Althingi (the Icelandic Parliament); AstraZeneca;
Augustinus Foundation; Australian National Health and Medical Research Council
(241944, 389875, 389891, 389892, 389938, 442915, 442981, 496739, 496688, 552485 and
613672); Australian Research Council (ARC grant DP0770096); Becket Foundation;
Biocenter (Finland); Biomedicum Helsinki Foundation, Boston Obesity Nutrition
Research Center; British Diabetes Association (1192); British Heart Foundation
(97020; PG/02/128); Busselton Population Medical Research Foundation; Cambridge
Institute for Medical Research; Cambridge NIHR Comprehensive Biomedical Research
Centre; CamStrad (UK); Cancer Research UK; Centre for Medical Systems Biology (The
Netherlands); Centre for Neurogenomics and Cognitive Research (The Netherlands);
Chief Scientist Office of the Scottish Government; Contrat Plan Etat Région
(France); Danish Centre for Health Technology Assessment; Danish Diabetes
Association; Danish Heart Foundation; Danish Pharmaceutical Association; Danish
Research Council; Deutsche Forschungsgemeinschaft (DFG; HE 1446/4-1); Department of
Health (UK); Diabetes UK; Diabetes & Inflammation Laboratory; Donald W. Reynolds
Foundation; Dresden University of Technology Funding Grant; Emil and Vera Cornell
Foundation; Erasmus Medical Center (Rotterdam); Erasmus University (Rotterdam);
European Commission (DG XII; QLG1-CT-2000-01643, QLG2-CT-2002-01254, LSHC-CT-2005,
LSHG-CT-2006-018947, LSHG-CT-2004-518153, LSH-2006-037593, LSHM-CT-2007-037273,
HEALTH-F2-2008-ENGAGE, HEALTH-F4-2007-201413, HEALTH-F4-2007-201550, FP7/2007-2013,
205419, 212111, 245536, SOC 95201408 05F02, WLRT-2001-01254); Federal Ministry of
Education and Research (Germany) (01AK803, 01EA9401, 01GI0823, 01GI0826, 01GP0209,
01GP0259, 01GS0820, 01GS0823, 01GS0824, 01GS0825, 01GS0830, 01GS0831, 01IG07015,
01KU0903, 01ZZ9603, 01ZZ0103, 01ZZ0403, 03ZIK012); Federal State of Mecklenburg-West
Pomerania; European Social Fund; Eve Appeal; Finnish Diabetes Research Foundation;
Finnish Foundation for Cardiovascular Research; Finnish Foundation for Pediatric
Research, Finnish Medical Society; Finska Läkaresällskapet,
Päivikki and Sakari Sohlberg Foundation, Folkhalsan Research Foundation;
Fond Européen pour le Développement Régional (France);
Fondation LeDucq (Paris, France); Foundation for Life and Health in Finland;
Foundation for Strategic Research (Sweden); Genetic Association Information Network;
German Research Council (KFO-152) German National Genome Research Net
‘NGFNplus’ (FKZ 01GS0823); German Research Center for Environmental
Health; Giorgi-Cavaglieri Foundation; GlaxoSmithKline; Göteborg Medical
Society; Great Wine Estates Auctions; Gyllenberg Foundation; Health Care Centers in
Vasa, Närpes and Korsholm; Healthway, Western Australia; Helmholtz Center
Munich; Helsinki University Central Hospital, Hjartavernd (the Icelandic Heart
Association); INSERM (France); Ib Henriksen Foundation; IZKF (B27); Jalmari and
Rauha Ahokas Foundation; Juho Vainio Foundation; Juvenile Diabetes Research
Foundation International (JDRF); Karolinska Institute; Knut and Alice Wallenberg
Foundation; Leenaards Foundation; Lundbeck Foundation Centre of Applied Medical
Genomics for Personalized Disease Prediction, Prevention and Care (LUCAMP); Lundberg
Foundation; Marie Curie Intra-European Fellowship; Medical Research Council (UK)
(G0000649, G0000934, G9521010D, G0500539, G0600331, G0601261, PrevMetSyn); Ministry
of Cultural Affairs and Social Ministry of the Federal State of Mecklenburg-West
Pomerania; Ministry for Health, Welfare and Sports (Netherlands); Ministry of
Education (Finland); Ministry of Education, Culture and Science (Netherlands);
Ministry of Internal Affairs and Health (Denmark); Ministry of Science, Education
and Sport of the Republic of Croatia (216-1080315-0302); Ministry of Science,
Research and the Arts Baden-Württemberg; Montreal Heart Institute
Foundation; Municipal Health Care Center and Hospital in Jakobstad; Municipality of
Rotterdam; Närpes Health Care Foundation; National Cancer Institute;
National Health and Medical Research Council of Australia; National Institute for
Health Research Cambridge Biomedical Research Centre; National Institute for Health
Research Oxford Biomedical Research Centre; National Institute for Health Research
comprehensive Biomedical Research Centre; National Institutes of Health
(263-MA-410953, AA07535, AA10248, AA014041, AA13320, AA13321, AA13326, CA047988,
CA65725, CA87969, CA49449, CA67262, CA50385, DA12854, DK58845, DK46200, DK062370,
DK063491, DK072193, HG002651, HL084729, HHSN268200625226C, HL71981, K23-DK080145,
K99-HL094535, M01-RR00425, MH084698, N01-AG12100, NO1-AG12109, N01-HC15103,
N01-HC25195, N01-HC35129, N01-HC45133, N01-HC55015, N01-HC55016, N01-HC55018,
N01-HC55019, N01-HC55020, N01-N01HC-55021, N01-HC55022, N01-HC55222, N01-HC75150,
N01-HC85079, N01-HC85080, N01-HG-65403, N01-HC85081, N01-HC85082; N01-HC85083;
N01-HC85084; N01-HC85085; N01-HC85086, N02-HL64278, P30-DK072488, R01-AG031890,
R01-DK073490, R01-DK075787, R01DK068336, R01DK075681, R01-HL59367, R01-HL086694,
R01-HL087641, R01-HL087647, R01-HL087652, R01-HL087676, R01-HL087679, R01-HL087700,
R01-HL088119, R01-MH59160, R01-MH59565, R01-MH59566, R01-MH59571, R01-MH59586,
R01-MH59587, R01-MH59588, R01-MH60870, R01-MH60879, R01-MH61675, R01-MH63706,
R01-MH67257, R01-MH79469, R01-MH79470, R01-MH81800, RL1-MH083268, UO1-CA098233,
U01-DK062418, U01-GM074518, U01-HG004402, U01-HG004399, U01-HL72515, U01-HL080295,
U01-HL084756, U54-RR020278, T32-HG00040, UL1-RR025005, Z01-HG000024); National
Alliance for Research on Schizophrenia and Depression (NARSAD); Netherlands Genomics
Initiative/Netherlands Consortium for Healthy Aging (050-060-810); Netherlands
Organisation for Scientific Research (NWO) (904-61-090, 904-61-193, 480-04-004,
400-05-717, SPI 56-464-1419, 175.010.2005.011, 911-03-012); Nord-Trøndelag
County Council; Nordic Center of Excellence in Disease Genetics; Novo Nordisk
Foundation; Norwegian Institute of Public Health; Ollqvist Foundation; Oxford NIHR
Biomedical Research Centre; Organization for the Health Research and Development
(10-000-1002); Paavo Nurmi Foundation; Paul Michael Donovan Charitable Foundation;
Perklén Foundation; Petrus and Augusta Hedlunds Foundation; Pew Scholar for
the Biomedical Sciences; Public Health and Risk Assessment, Health & Consumer
Protection (2004310); Research Foundation of Copenhagen County; Research Institute
for Diseases in the Elderly (014-93-015; RIDE2); Robert Dawson Evans Endowment;
Royal Society (UK); Royal Swedish Academy of Science; Sahlgrenska Center for
Cardiovascular and Metabolic Research (CMR, no. A305: 188); Siemens Healthcare,
Erlangen, Germany; Sigrid Juselius Foundation; Signe and Ane Gyllenberg Foundation;
Science Funding programme (UK); Social Insurance Institution of Finland;
Söderberg’s Foundation; South Tyrol Ministry of Health; South
Tyrolean Sparkasse Foundation; State of Bavaria; Stockholm County Council (560183);
Susan G. Komen Breast Cancer Foundation; Swedish Cancer Society; Swedish Cultural
Foundation in Finland; Swedish Foundation for Strategic Research; Swedish Heart-Lung
Foundation; Swedish Medical Research Council (8691, K2007-66X-20270-01-3,
K2010-54X-09894-19-3, K2010-54X-09894-19-3, 2006-3832); Swedish Research Council;
Swedish Society of Medicine; Swiss National Science Foundation (33CSCO-122661,
310000-112552, 3100AO-116323/1); Torsten and Ragnar Söderberg’s
Foundation; Université Henri Poincaré-Nancy 1, Région
Lorraine, Communauté Urbaine du Grand Nancy; University Hospital Medical
funds to Tampere; University Hospital Oulu; University of Oulu, Finland (75617);
Västra Götaland Foundation; Walter E. Nichols, M.D., and Eleanor
Nichols endowments; Wellcome Trust (068545, 072960, 075491, 076113, 077016, 079557,
079895, 081682, 083270, 085301, 086596); Western Australian DNA Bank; Western
Australian Genetic Epidemiology Resource; Yrjö Jahnsson Foundation.</p></ack><fn-group><fn id="FN3" fn-type="con"><p><bold>Author contributions</bold></p><p>A full list of author contributions appears in the <xref rid="SD1" ref-type="supplementary-material">Supplementary Note</xref>.</p></fn><fn id="FN4" fn-type="conflict"><p><bold>Competing interests statement</bold></p><p>The authors declare competing financial interests. A full list of competing
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population-based linkage analyses</article-title><source>Am J Hum Genet</source><volume>81</volume><fpage>559</fpage><lpage>75</lpage><year>2007</year><pub-id pub-id-type="pmid">17701901</pub-id></element-citation></ref><ref id="R52"><label>52</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhong</surname><given-names>H</given-names></name><name><surname>Yang</surname><given-names>X</given-names></name><name><surname>Kaplan</surname><given-names>LM</given-names></name><name><surname>Molony</surname><given-names>C</given-names></name><name><surname>Schadt</surname><given-names>EE</given-names></name></person-group><article-title>Integrating pathway analysis and genetics of gene expression for
genome-wide association studies</article-title><source>Am J Hum Genet</source><volume>86</volume><fpage>581</fpage><lpage>91</lpage><year>2010</year><pub-id pub-id-type="pmid">20346437</pub-id></element-citation></ref></ref-list></back><floats-group><fig id="F1" position="float"><label>Figure 1</label><caption><title>Genome-wide association results for the BMI meta-analysis</title><p>(<bold>a</bold>) Manhattan plot showing the significance of association
between all SNPs and BMI in the stage 1 meta-analysis, highlighting SNPs
previously reported to show genome-wide significant association with BMI
(blue), weight or waist circumference (green), and the 18 new regions
described here (red). The 19 SNPs that reached genome-wide significance at
Stage 1 (13 previously reported and 6 new) are listed in <xref rid="T1" ref-type="table">Table 1</xref>). (<bold>b</bold>) Quantile-quantile
(Q-Q) plot of SNPs in stage 1 meta-analysis (black) and after removing any
SNPs within 1 Mb of the 10 previously reported genome-wide significant hits
for BMI (blue), after additionally excluding SNPs from the four loci for
waist/weight (green) and after excluding SNPs from all 32 confirmed loci
(red). The plot was abridged at the Y-axis (at <italic>P</italic> <
10<sup>−20</sup>) to better visualise the excess of small
<italic>P</italic>-values after excluding the 32 confirmed loci (<xref rid="SD1" ref-type="supplementary-material">Supplementary Fig. 3</xref>shows full-scale Q-Q plot). The shaded region is the 95%
concentration band. (<bold>c</bold>) Plot of effect size (in inverse
normally transformed units (invBMI)) versus effect allele frequency of newly
identified and previously identified BMI variants after stage 1 +
stage 2 analysis; including the 10 previously identified BMI loci (blue),
the four previously identified waist and weight loci (green) and the 18
newly identified BMI loci (blue). The dotted lines represent the minimum
effect sizes that could be identified for a given effect-allele frequency
with 80% (upper line), 50% (middle line), and 10%
(lower line) power, assuming a sample size of 123,000 individuals and a
α-level of 5×10<sup>−8</sup>.</p></caption><graphic xlink:href="nihms237282f1"></graphic></fig><fig id="F2" position="float"><label>Figure 2</label><caption><title>Combined impact of risk alleles on BMI/obesity</title><p>(<bold>a</bold>) Combined effect of risk alleles on average BMI in the
population-based Atherosclerosis Risk in Communities (ARIC) study (n
= 8,120 individuals of European descent). For each individual, the
number of “best guess” replicated (n = 32) risk
alleles from imputed data (0,1,2) per SNP was weighted for their relative
effect sizes estimated from the stage 2 data. Weighted risk alleles were
summed for each individual and the overall individual sum was rounded to the
nearest integer to represent the individual’s risk allele score
(range 16–44). Along the x-axis, individuals in each risk allele
category are shown (grouped ≤21 and ≥38 at the extremes),
and the mean BMI (+/− SEM) is plotted (y axis on right),
with the line representing the regression of the mean BMI values across the
risk-allele scores. The histogram (y-axis on left) represents the number of
individuals in each risk-score category. (<bold>b</bold>) The area under the
ROC curve (AUC) of two different models predicting the risk of obesity (BMI
= ≥30 kg/m<sup>2</sup>) in the n = 8,120 genotyped
individuals of European descent in the ARIC Study. Model 1, represented by
the solid line, includes age, age<sup>2</sup>, and sex (AUC = 0.515,
<italic>P</italic> = 0.023 for difference from
AUC<sub>null</sub> = 0.50). Model 2, represented by the dashed
line, includes age, age<sup>2</sup>, sex, and the n = 32 confirmed
BMI SNPs (AUC = 0.0575, <italic>P</italic> <
10<sup>−5</sup> for difference from AUC<sub>null</sub> =
0.50). The difference between both AUCs is significant (<italic>P</italic>< 10<sup>−4</sup>).</p></caption><graphic xlink:href="nihms237282f2"></graphic></fig><fig id="F3" position="float"><label>Figure 3</label><caption><title>Regional plots of selected replicating BMI loci with missense and CNV
variants</title><p>SNPs are plotted by position on chromosome against association with BMI
(−log<sub>10</sub><italic>P-</italic>value). The SNP name shown on the plot was the most
significant SNP after stage 1 meta-analysis. Estimated recombination rates
(from HapMap) are plotted in cyan to reflect the local LD structure. The
SNPs surrounding the most significant SNP are color-coded to reflect their
LD with this SNP (taken from pairwise r<sup>2</sup> values from the HapMap
CEU database, <ext-link ext-link-type="uri" xlink:href="www.hapmap.org">www.hapmap.org</ext-link>). Genes, position of exons, and direction of
transcription from UCSC genome browser (<ext-link ext-link-type="uri" xlink:href="http://genome.ucsc.edu">http://genome.ucsc.edu</ext-link>)
are noted. Hashmarks represent SNP positions available in the meta-analysis.
(<bold>a, b, c</bold>) Missense variants noted with their amino acid
change for the gene noted above the plot. (<bold>d</bold>) Structural
haplotypes and BMI association signal in the <italic>GPRC5B</italic> region.
A 21 kb deletion polymorphism is associated with 4 SNPs
(r<sup>2</sup>=1.0) that comprise the best haplogroup associating
with BMI. Plots were generated using LocusZoom (<ext-link ext-link-type="uri" xlink:href="http://csg.sph.umich.edu/locuszoom">http://csg.sph.umich.edu/locuszoom</ext-link>).</p></caption><graphic xlink:href="nihms237282f3"></graphic></fig><fig id="F4" position="float"><label>Figure 4</label><caption><title>Phenotypic variance explained by common variants</title><p>(<bold>a</bold>) Variance explained is higher when SNPs not reaching
genome-wide significance are included in the prediction model. The y-axis
represents the proportion of variance explained at different
<italic>P-</italic>value thresholds from stage 1 meta-analysis. Results
are given for three studies (RSII, RSIII, QIMR), which were not included in
the meta-analysis, after exclusion of all samples from The Netherlands (for
RSII and RSIII) and the United Kingdom (for QIMR) from the discovery
analysis for this sub-analysis. The dotted line represents the weighted
average of the explained variance of three validation sets. (<bold>b</bold>)
Cumulative number of susceptibility loci expected to be discovered,
including those we have already identified and others that have yet to be
detected, by the expected percentage of phenotypic variation explained and
sample size required for a one-stage GWA study assuming a GC correction is
utilized. The projections are based on loci that achieved a significance
level of <italic>P</italic> < 5×10<sup>−8</sup> in the
joint analysis of stage 1 and stage 2 and the distribution of their effect
sizes in stage 2. The dotted red line corresponds to the expected phenotypic
variance explained by the 22 loci that are expected to be discovered in a
one-stage GWAS with the sample size of stage 1 of this study.</p></caption><graphic xlink:href="nihms237282f4"></graphic></fig><fig id="F5" position="float"><label>Figure 5</label><caption><title>Second signal at the MC4R locus contributing to BMI</title><p>SNPs are plotted by position in a 1 Mb window of chromosome 18 against
association with BMI ( log<sub>10</sub><italic>P-</italic>value). Panel (<bold>a</bold>) highlights the most
significant SNP in stage 1 meta-analysis, panel (<bold>b</bold>) the most
significant SNP after conditional analysis where the model included the most
strongly associated SNP from panel A as a covariate. Estimated recombination
rates (from HapMap) are plotted in cyan to reflect the local LD structure.
The SNPs surrounding the most significant SNP are color-coded to reflect
their LD with this SNP (taken from pairwise r<sup>2</sup> values from the
HapMap CEU database, <ext-link ext-link-type="uri" xlink:href="www.hapmap.org">www.hapmap.org</ext-link>). Genes, exons,
and direction of transcription from UCSC genome browser (genome.ucsc.edu)
are noted. Hashmarks at the top of the figure represent positions of SNPs in
the meta-analysis. Regional plots were generated using LocusZoom (<ext-link ext-link-type="uri" xlink:href="http://csg.sph.umich.edu/locuszoom">http://csg.sph.umich.edu/locuszoom</ext-link>).</p></caption><graphic xlink:href="nihms237282f5"></graphic></fig><table-wrap id="T1" position="float" orientation="landscape"><label>Table 1</label><caption><p>Stage 1 and stage 2 results of the 32 SNPs that were associated with BMI at
genome-wide significance (P < 5.10<sup>−8</sup>) levels.</p></caption><table frame="hsides" rules="groups"><thead><tr><th valign="top" rowspan="2" align="left" colspan="1">SNP</th><th valign="top" rowspan="2" align="left" colspan="1">Nearest gene</th><th valign="top" rowspan="2" align="left" colspan="1">Other nearby genes<xref rid="TFN1" ref-type="table-fn">*</xref></th><th valign="top" rowspan="2" align="center" colspan="1">Chr</th><th valign="top" rowspan="2" align="center" colspan="1">Position<xref rid="TFN2" ref-type="table-fn">**</xref> (bp)</th><th colspan="2" valign="bottom" align="center" rowspan="1">Alleles<xref rid="TFN2" ref-type="table-fn">**</xref></th><th valign="bottom" rowspan="2" align="center" colspan="1">Frequency effect allele
(%)</th><th valign="bottom" rowspan="2" align="center" colspan="1">Per allele change in BMI
beta (se)<xref rid="TFN3" ref-type="table-fn">***</xref></th><th valign="top" rowspan="2" align="center" colspan="1">Explained variance
(%)</th><th valign="top" rowspan="2" align="center" colspan="1">Stage 1
<italic>P</italic>-value</th><th valign="top" rowspan="2" align="center" colspan="1">Stage 2
<italic>P</italic>-value</th><th colspan="2" valign="bottom" align="center" rowspan="1">Stage 1 + 2</th></tr><tr><th valign="bottom" align="center" rowspan="1" colspan="1">Effect</th><th valign="bottom" align="center" rowspan="1" colspan="1">Other</th><th valign="bottom" align="center" rowspan="1" colspan="1">n</th><th valign="bottom" align="center" rowspan="1" colspan="1"><italic>P</italic>-value</th></tr></thead><tbody><tr><td colspan="14" align="left" valign="top" rowspan="1"><bold><underline>Previous BMI loci</underline></bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs1558902</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>FTO</italic></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">16</td><td align="center" valign="top" rowspan="1" colspan="1">52,361,075</td><td align="center" valign="top" rowspan="1" colspan="1">a</td><td align="center" valign="top" rowspan="1" colspan="1">t</td><td align="center" valign="top" rowspan="1" colspan="1">42%</td><td align="center" valign="top" rowspan="1" colspan="1">0.39 (0.02)</td><td align="center" valign="top" rowspan="1" colspan="1">0.34%</td><td align="center" valign="top" rowspan="1" colspan="1">2.05E-62</td><td align="center" valign="top" rowspan="1" colspan="1">1.007E-60</td><td align="center" valign="top" rowspan="1" colspan="1">192,344</td><td align="center" valign="top" rowspan="1" colspan="1">4.8E-120</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs2867125</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>TMEM18</italic></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">612,827</td><td align="center" valign="top" rowspan="1" colspan="1">c</td><td align="center" valign="top" rowspan="1" colspan="1">t</td><td align="center" valign="top" rowspan="1" colspan="1">83%</td><td align="center" valign="top" rowspan="1" colspan="1">0.31 (0.03)</td><td align="center" valign="top" rowspan="1" colspan="1">0.15%</td><td align="center" valign="top" rowspan="1" colspan="1">2.42E-22</td><td align="center" valign="top" rowspan="1" colspan="1">4.42E-30</td><td align="center" valign="top" rowspan="1" colspan="1">197,806</td><td align="center" valign="top" rowspan="1" colspan="1">2.77E-49</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs571312</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>MC4R</italic><xref rid="TFN5" ref-type="table-fn">B</xref></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">18</td><td align="center" valign="top" rowspan="1" colspan="1">55,990,749</td><td align="center" valign="top" rowspan="1" colspan="1">a</td><td align="center" valign="top" rowspan="1" colspan="1">c</td><td align="center" valign="top" rowspan="1" colspan="1">24%</td><td align="center" valign="top" rowspan="1" colspan="1">0.23 (0.03)</td><td align="center" valign="top" rowspan="1" colspan="1">0.10%</td><td align="center" valign="top" rowspan="1" colspan="1">1.82E-22</td><td align="center" valign="top" rowspan="1" colspan="1">3.19E-21</td><td align="center" valign="top" rowspan="1" colspan="1">203,600</td><td align="center" valign="top" rowspan="1" colspan="1">6.43E-42</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs10938397</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>GNPDA2</italic></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">4</td><td align="center" valign="top" rowspan="1" colspan="1">44,877,284</td><td align="center" valign="top" rowspan="1" colspan="1">g</td><td align="center" valign="top" rowspan="1" colspan="1">a</td><td align="center" valign="top" rowspan="1" colspan="1">43%</td><td align="center" valign="top" rowspan="1" colspan="1">0.18 (0.02)</td><td align="center" valign="top" rowspan="1" colspan="1">0.08%</td><td align="center" valign="top" rowspan="1" colspan="1">4.35E-17</td><td align="center" valign="top" rowspan="1" colspan="1">1.45E-15</td><td align="center" valign="top" rowspan="1" colspan="1">197,008</td><td align="center" valign="top" rowspan="1" colspan="1">3.78E-31</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs10767664</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>BDNF</italic><xref rid="TFN5" ref-type="table-fn">B</xref>,<xref rid="TFN6" ref-type="table-fn">M</xref></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">11</td><td align="center" valign="top" rowspan="1" colspan="1">27,682,562</td><td align="center" valign="top" rowspan="1" colspan="1">a</td><td align="center" valign="top" rowspan="1" colspan="1">t</td><td align="center" valign="top" rowspan="1" colspan="1">78%</td><td align="center" valign="top" rowspan="1" colspan="1">0.19 (0.03)</td><td align="center" valign="top" rowspan="1" colspan="1">0.07%</td><td align="center" valign="top" rowspan="1" colspan="1">5.53E-13</td><td align="center" valign="top" rowspan="1" colspan="1">1.17E-14</td><td align="center" valign="top" rowspan="1" colspan="1">204,158</td><td align="center" valign="top" rowspan="1" colspan="1">4.69E-26</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs2815752</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>NEGR1</italic><xref rid="TFN7" ref-type="table-fn">C</xref>,<xref rid="TFN4" ref-type="table-fn">Q</xref></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">72,585,028</td><td align="center" valign="top" rowspan="1" colspan="1">a</td><td align="center" valign="top" rowspan="1" colspan="1">g</td><td align="center" valign="top" rowspan="1" colspan="1">61%</td><td align="center" valign="top" rowspan="1" colspan="1">0.13 (0.02)</td><td align="center" valign="top" rowspan="1" colspan="1">0.04%</td><td align="center" valign="top" rowspan="1" colspan="1">1.17E-14</td><td align="center" valign="top" rowspan="1" colspan="1">2.29E-09</td><td align="center" valign="top" rowspan="1" colspan="1">198,380</td><td align="center" valign="top" rowspan="1" colspan="1">1.61E-22</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs7359397</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>SH2B1</italic><xref rid="TFN4" ref-type="table-fn">Q</xref>,<xref rid="TFN5" ref-type="table-fn">B</xref>,<xref rid="TFN6" ref-type="table-fn">M</xref></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>APOB48R</italic><xref rid="TFN4" ref-type="table-fn">Q</xref>,<xref rid="TFN6" ref-type="table-fn">M</xref><italic>, SULT1A2</italic><xref rid="TFN4" ref-type="table-fn">Q</xref>,<xref rid="TFN6" ref-type="table-fn">M</xref><italic>, AC138894.2</italic><xref rid="TFN6" ref-type="table-fn">M</xref><italic>,
ATXN2L</italic><xref rid="TFN6" ref-type="table-fn">M</xref><italic>, TUFM</italic><xref rid="TFN4" ref-type="table-fn">Q</xref></td><td align="center" valign="top" rowspan="1" colspan="1">16</td><td align="center" valign="top" rowspan="1" colspan="1">28,793,160</td><td align="center" valign="top" rowspan="1" colspan="1">t</td><td align="center" valign="top" rowspan="1" colspan="1">c</td><td align="center" valign="top" rowspan="1" colspan="1">40%</td><td align="center" valign="top" rowspan="1" colspan="1">0.15 (0.02)</td><td align="center" valign="top" rowspan="1" colspan="1">0.05%</td><td align="center" valign="top" rowspan="1" colspan="1">1.75E-10</td><td align="center" valign="top" rowspan="1" colspan="1">7.89E-12</td><td align="center" valign="top" rowspan="1" colspan="1">204,309</td><td align="center" valign="top" rowspan="1" colspan="1">1.88E-20</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs9816226</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>ETV5</italic></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">3</td><td align="center" valign="top" rowspan="1" colspan="1">187,317,193</td><td align="center" valign="top" rowspan="1" colspan="1">t</td><td align="center" valign="top" rowspan="1" colspan="1">a</td><td align="center" valign="top" rowspan="1" colspan="1">82%</td><td align="center" valign="top" rowspan="1" colspan="1">0.14 (0.03)</td><td align="center" valign="top" rowspan="1" colspan="1">0.03%</td><td align="center" valign="top" rowspan="1" colspan="1">7.61E-14</td><td align="center" valign="top" rowspan="1" colspan="1">1.15E-06</td><td align="center" valign="top" rowspan="1" colspan="1">196,221</td><td align="center" valign="top" rowspan="1" colspan="1">1.69E-18</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs3817334</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>MTCH2</italic><xref rid="TFN4" ref-type="table-fn">Q</xref>,<xref rid="TFN6" ref-type="table-fn">M</xref></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>NDUFS3</italic><xref rid="TFN4" ref-type="table-fn">Q</xref><italic>, CUGBP1</italic><xref rid="TFN4" ref-type="table-fn">Q</xref></td><td align="center" valign="top" rowspan="1" colspan="1">11</td><td align="center" valign="top" rowspan="1" colspan="1">47,607,569</td><td align="center" valign="top" rowspan="1" colspan="1">t</td><td align="center" valign="top" rowspan="1" colspan="1">c</td><td align="center" valign="top" rowspan="1" colspan="1">41%</td><td align="center" valign="top" rowspan="1" colspan="1">0.06 (0.02)</td><td align="center" valign="top" rowspan="1" colspan="1">0.01%</td><td align="center" valign="top" rowspan="1" colspan="1">4.79E-11</td><td align="center" valign="top" rowspan="1" colspan="1">1.10E-03</td><td align="center" valign="top" rowspan="1" colspan="1">191,943</td><td align="center" valign="top" rowspan="1" colspan="1">1.59E-12</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs29941</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>KCTD15</italic></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">19</td><td align="center" valign="top" rowspan="1" colspan="1">39,001,372</td><td align="center" valign="top" rowspan="1" colspan="1">g</td><td align="center" valign="top" rowspan="1" colspan="1">a</td><td align="center" valign="top" rowspan="1" colspan="1">67%</td><td align="center" valign="top" rowspan="1" colspan="1">0.06 (0.02)</td><td align="center" valign="top" rowspan="1" colspan="1">0.00%</td><td align="center" valign="top" rowspan="1" colspan="1">1.31E-09</td><td align="center" valign="top" rowspan="1" colspan="1">2.40E-02</td><td align="center" valign="top" rowspan="1" colspan="1">192,872</td><td align="center" valign="top" rowspan="1" colspan="1">3.01E-09</td></tr><tr><td colspan="14" align="left" valign="top" rowspan="1"><bold><underline>Previous waist & weight loci</underline></bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs543874</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>SEC16B</italic></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">176,156,103</td><td align="center" valign="top" rowspan="1" colspan="1">g</td><td align="center" valign="top" rowspan="1" colspan="1">a</td><td align="center" valign="top" rowspan="1" colspan="1">19%</td><td align="center" valign="top" rowspan="1" colspan="1">0.22 (0.03)</td><td align="center" valign="top" rowspan="1" colspan="1">0.07%</td><td align="center" valign="top" rowspan="1" colspan="1">1.66E-13</td><td align="center" valign="top" rowspan="1" colspan="1">2.41E-11</td><td align="center" valign="top" rowspan="1" colspan="1">179,414</td><td align="center" valign="top" rowspan="1" colspan="1">3.56E-23</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs987237</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>TFAP2B</italic></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">6</td><td align="center" valign="top" rowspan="1" colspan="1">50,911,009</td><td align="center" valign="top" rowspan="1" colspan="1">g</td><td align="center" valign="top" rowspan="1" colspan="1">a</td><td align="center" valign="top" rowspan="1" colspan="1">18%</td><td align="center" valign="top" rowspan="1" colspan="1">0.13 (0.03)</td><td align="center" valign="top" rowspan="1" colspan="1">0.03%</td><td align="center" valign="top" rowspan="1" colspan="1">5.97E-16</td><td align="center" valign="top" rowspan="1" colspan="1">2.40E-06</td><td align="center" valign="top" rowspan="1" colspan="1">195,776</td><td align="center" valign="top" rowspan="1" colspan="1">2.90E-20</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs7138803</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>FAIM2</italic></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">12</td><td align="center" valign="top" rowspan="1" colspan="1">48,533,735</td><td align="center" valign="top" rowspan="1" colspan="1">a</td><td align="center" valign="top" rowspan="1" colspan="1">g</td><td align="center" valign="top" rowspan="1" colspan="1">38%</td><td align="center" valign="top" rowspan="1" colspan="1">0.12 (0.02)</td><td align="center" valign="top" rowspan="1" colspan="1">0.04%</td><td align="center" valign="top" rowspan="1" colspan="1">3.96E-11</td><td align="center" valign="top" rowspan="1" colspan="1">7.82E-08</td><td align="center" valign="top" rowspan="1" colspan="1">200,064</td><td align="center" valign="top" rowspan="1" colspan="1">1.82E-17</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs10150332</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>NRXN3</italic></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">14</td><td align="center" valign="top" rowspan="1" colspan="1">79,006,717</td><td align="center" valign="top" rowspan="1" colspan="1">c</td><td align="center" valign="top" rowspan="1" colspan="1">t</td><td align="center" valign="top" rowspan="1" colspan="1">21%</td><td align="center" valign="top" rowspan="1" colspan="1">0.13 (0.03)</td><td align="center" valign="top" rowspan="1" colspan="1">0.02%</td><td align="center" valign="top" rowspan="1" colspan="1">2.03E-07</td><td align="center" valign="top" rowspan="1" colspan="1">2.86E-05</td><td align="center" valign="top" rowspan="1" colspan="1">183,022</td><td align="center" valign="top" rowspan="1" colspan="1">2.75E-11</td></tr><tr><td colspan="14" align="left" valign="top" rowspan="1"><bold><underline>Newly identified BMI loci</underline></bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs713586</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>RBJ</italic></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>ADCY3</italic><xref rid="TFN4" ref-type="table-fn">Q</xref>, <xref rid="TFN6" ref-type="table-fn">M</xref><italic>, POMC</italic><xref rid="TFN4" ref-type="table-fn">Q</xref>,<xref rid="TFN5" ref-type="table-fn">B</xref></td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">25,011,512</td><td align="center" valign="top" rowspan="1" colspan="1">c</td><td align="center" valign="top" rowspan="1" colspan="1">t</td><td align="center" valign="top" rowspan="1" colspan="1">47%</td><td align="center" valign="top" rowspan="1" colspan="1">0.14 (0.02)</td><td align="center" valign="top" rowspan="1" colspan="1">0.06%</td><td align="center" valign="top" rowspan="1" colspan="1">1.80E-07</td><td align="center" valign="top" rowspan="1" colspan="1">1.44E-16</td><td align="center" valign="top" rowspan="1" colspan="1">230,748</td><td align="center" valign="top" rowspan="1" colspan="1">6.17E-22</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs12444979</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>GPRC5B</italic><xref rid="TFN7" ref-type="table-fn">C</xref>,<xref rid="TFN4" ref-type="table-fn">Q</xref></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>IQCK</italic><xref rid="TFN4" ref-type="table-fn">Q</xref></td><td align="center" valign="top" rowspan="1" colspan="1">16</td><td align="center" valign="top" rowspan="1" colspan="1">19,841,101</td><td align="center" valign="top" rowspan="1" colspan="1">c</td><td align="center" valign="top" rowspan="1" colspan="1">t</td><td align="center" valign="top" rowspan="1" colspan="1">87%</td><td align="center" valign="top" rowspan="1" colspan="1">0.17 (0.03)</td><td align="center" valign="top" rowspan="1" colspan="1">0.04%</td><td align="center" valign="top" rowspan="1" colspan="1">4.20E-11</td><td align="center" valign="top" rowspan="1" colspan="1">8.13E-12</td><td align="center" valign="top" rowspan="1" colspan="1">239,715</td><td align="center" valign="top" rowspan="1" colspan="1">2.91E-21</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs2241423</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>MAP2K5</italic></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>LBXCOR1</italic><xref rid="TFN6" ref-type="table-fn">M</xref></td><td align="center" valign="top" rowspan="1" colspan="1">15</td><td align="center" valign="top" rowspan="1" colspan="1">65,873,892</td><td align="center" valign="top" rowspan="1" colspan="1">g</td><td align="center" valign="top" rowspan="1" colspan="1">a</td><td align="center" valign="top" rowspan="1" colspan="1">78%</td><td align="center" valign="top" rowspan="1" colspan="1">0.13 (0.02)</td><td align="center" valign="top" rowspan="1" colspan="1">0.03%</td><td align="center" valign="top" rowspan="1" colspan="1">1.15E-10</td><td align="center" valign="top" rowspan="1" colspan="1">1.59E-09</td><td align="center" valign="top" rowspan="1" colspan="1">227,950</td><td align="center" valign="top" rowspan="1" colspan="1">1.19E-18</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs2287019</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>QPCTL</italic></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>GIPR</italic><xref rid="TFN5" ref-type="table-fn">B</xref>,<xref rid="TFN6" ref-type="table-fn">M</xref></td><td align="center" valign="top" rowspan="1" colspan="1">19</td><td align="center" valign="top" rowspan="1" colspan="1">50,894,012</td><td align="center" valign="top" rowspan="1" colspan="1">c</td><td align="center" valign="top" rowspan="1" colspan="1">t</td><td align="center" valign="top" rowspan="1" colspan="1">80%</td><td align="center" valign="top" rowspan="1" colspan="1">0.15 (0.03)</td><td align="center" valign="top" rowspan="1" colspan="1">0.04%</td><td align="center" valign="top" rowspan="1" colspan="1">3.18E-07</td><td align="center" valign="top" rowspan="1" colspan="1">1.40E-10</td><td align="center" valign="top" rowspan="1" colspan="1">194,564</td><td align="center" valign="top" rowspan="1" colspan="1">1.88E-16</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs1514175</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>TNNI3K</italic></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">74,764,232</td><td align="center" valign="top" rowspan="1" colspan="1">a</td><td align="center" valign="top" rowspan="1" colspan="1">g</td><td align="center" valign="top" rowspan="1" colspan="1">43%</td><td align="center" valign="top" rowspan="1" colspan="1">0.07 (0.02)</td><td align="center" valign="top" rowspan="1" colspan="1">0.02%</td><td align="center" valign="top" rowspan="1" colspan="1">1.36E-09</td><td align="center" valign="top" rowspan="1" colspan="1">7.04E-06</td><td align="center" valign="top" rowspan="1" colspan="1">227,900</td><td align="center" valign="top" rowspan="1" colspan="1">8.16E-14</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs13107325</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>SLC39A8</italic><xref rid="TFN4" ref-type="table-fn">Q</xref>,<xref rid="TFN6" ref-type="table-fn">M</xref></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">4</td><td align="center" valign="top" rowspan="1" colspan="1">103,407,732</td><td align="center" valign="top" rowspan="1" colspan="1">t</td><td align="center" valign="top" rowspan="1" colspan="1">c</td><td align="center" valign="top" rowspan="1" colspan="1">7%</td><td align="center" valign="top" rowspan="1" colspan="1">0.19 (0.04)</td><td align="center" valign="top" rowspan="1" colspan="1">0.03%</td><td align="center" valign="top" rowspan="1" colspan="1">1.37E-07</td><td align="center" valign="top" rowspan="1" colspan="1">1.93E-07</td><td align="center" valign="top" rowspan="1" colspan="1">245,378</td><td align="center" valign="top" rowspan="1" colspan="1">1.50E-13</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs2112347</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>FLJ35779</italic><xref rid="TFN6" ref-type="table-fn">M</xref></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>HMGCR</italic><xref rid="TFN5" ref-type="table-fn">B</xref></td><td align="center" valign="top" rowspan="1" colspan="1">5</td><td align="center" valign="top" rowspan="1" colspan="1">75,050,998</td><td align="center" valign="top" rowspan="1" colspan="1">t</td><td align="center" valign="top" rowspan="1" colspan="1">g</td><td align="center" valign="top" rowspan="1" colspan="1">63%</td><td align="center" valign="top" rowspan="1" colspan="1">0.10 (0.02)</td><td align="center" valign="top" rowspan="1" colspan="1">0.02%</td><td align="center" valign="top" rowspan="1" colspan="1">4.76E-08</td><td align="center" valign="top" rowspan="1" colspan="1">8.29E-07</td><td align="center" valign="top" rowspan="1" colspan="1">231,729</td><td align="center" valign="top" rowspan="1" colspan="1">2.17E-13</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs10968576</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>LRRN6C</italic></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">9</td><td align="center" valign="top" rowspan="1" colspan="1">28,404,339</td><td align="center" valign="top" rowspan="1" colspan="1">g</td><td align="center" valign="top" rowspan="1" colspan="1">a</td><td align="center" valign="top" rowspan="1" colspan="1">31%</td><td align="center" valign="top" rowspan="1" colspan="1">0.11 (0.02)</td><td align="center" valign="top" rowspan="1" colspan="1">0.02%</td><td align="center" valign="top" rowspan="1" colspan="1">1.88E-08</td><td align="center" valign="top" rowspan="1" colspan="1">3.19E-06</td><td align="center" valign="top" rowspan="1" colspan="1">216,916</td><td align="center" valign="top" rowspan="1" colspan="1">2.65E-13</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs3810291</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>TMEM160</italic><xref rid="TFN4" ref-type="table-fn">Q</xref></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>ZC3H4</italic><xref rid="TFN4" ref-type="table-fn">Q</xref></td><td align="center" valign="top" rowspan="1" colspan="1">19</td><td align="center" valign="top" rowspan="1" colspan="1">52,260,843</td><td align="center" valign="top" rowspan="1" colspan="1">a</td><td align="center" valign="top" rowspan="1" colspan="1">g</td><td align="center" valign="top" rowspan="1" colspan="1">67%</td><td align="center" valign="top" rowspan="1" colspan="1">0.09 (0.02)</td><td align="center" valign="top" rowspan="1" colspan="1">0.02%</td><td align="center" valign="top" rowspan="1" colspan="1">1.04E-07</td><td align="center" valign="top" rowspan="1" colspan="1">1.59E-06</td><td align="center" valign="top" rowspan="1" colspan="1">233,512</td><td align="center" valign="top" rowspan="1" colspan="1">1.64E-12</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs887912</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>FANCL</italic></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">59,156,381</td><td align="center" valign="top" rowspan="1" colspan="1">t</td><td align="center" valign="top" rowspan="1" colspan="1">c</td><td align="center" valign="top" rowspan="1" colspan="1">29%</td><td align="center" valign="top" rowspan="1" colspan="1">0.10 (0.02)</td><td align="center" valign="top" rowspan="1" colspan="1">0.03%</td><td align="center" valign="top" rowspan="1" colspan="1">2.69E-06</td><td align="center" valign="top" rowspan="1" colspan="1">1.72E-07</td><td align="center" valign="top" rowspan="1" colspan="1">242,807</td><td align="center" valign="top" rowspan="1" colspan="1">1.79E-12</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs13078807</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>CADM2</italic></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">3</td><td align="center" valign="top" rowspan="1" colspan="1">85,966,840</td><td align="center" valign="top" rowspan="1" colspan="1">g</td><td align="center" valign="top" rowspan="1" colspan="1">a</td><td align="center" valign="top" rowspan="1" colspan="1">20%</td><td align="center" valign="top" rowspan="1" colspan="1">0.10 (0.02)</td><td align="center" valign="top" rowspan="1" colspan="1">0.02%</td><td align="center" valign="top" rowspan="1" colspan="1">9.81E-08</td><td align="center" valign="top" rowspan="1" colspan="1">5.32E-05</td><td align="center" valign="top" rowspan="1" colspan="1">237,404</td><td align="center" valign="top" rowspan="1" colspan="1">3.94E-11</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs11847697</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>PRKD1</italic></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">14</td><td align="center" valign="top" rowspan="1" colspan="1">29,584,863</td><td align="center" valign="top" rowspan="1" colspan="1">t</td><td align="center" valign="top" rowspan="1" colspan="1">c</td><td align="center" valign="top" rowspan="1" colspan="1">4%</td><td align="center" valign="top" rowspan="1" colspan="1">0.17 (0.05)</td><td align="center" valign="top" rowspan="1" colspan="1">0.01%</td><td align="center" valign="top" rowspan="1" colspan="1">1.11E-08</td><td align="center" valign="top" rowspan="1" colspan="1">2.25E-04</td><td align="center" valign="top" rowspan="1" colspan="1">241,667</td><td align="center" valign="top" rowspan="1" colspan="1">5.76E-11</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs2890652</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>LRP1B</italic></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">142,676,401</td><td align="center" valign="top" rowspan="1" colspan="1">c</td><td align="center" valign="top" rowspan="1" colspan="1">t</td><td align="center" valign="top" rowspan="1" colspan="1">18%</td><td align="center" valign="top" rowspan="1" colspan="1">0.09 (0.03)</td><td align="center" valign="top" rowspan="1" colspan="1">0.02%</td><td align="center" valign="top" rowspan="1" colspan="1">2.38E-07</td><td align="center" valign="top" rowspan="1" colspan="1">9.47E-05</td><td align="center" valign="top" rowspan="1" colspan="1">209,068</td><td align="center" valign="top" rowspan="1" colspan="1">1.35E-10</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs1555543</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>PTBP2</italic></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">96,717,385</td><td align="center" valign="top" rowspan="1" colspan="1">c</td><td align="center" valign="top" rowspan="1" colspan="1">a</td><td align="center" valign="top" rowspan="1" colspan="1">59%</td><td align="center" valign="top" rowspan="1" colspan="1">0.06 (0.02)</td><td align="center" valign="top" rowspan="1" colspan="1">0.01%</td><td align="center" valign="top" rowspan="1" colspan="1">7.65E-07</td><td align="center" valign="top" rowspan="1" colspan="1">4.48E-05</td><td align="center" valign="top" rowspan="1" colspan="1">243,013</td><td align="center" valign="top" rowspan="1" colspan="1">3.68E-10</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs4771122</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>MTIF3</italic></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>GTF3A</italic><xref rid="TFN4" ref-type="table-fn">Q</xref></td><td align="center" valign="top" rowspan="1" colspan="1">13</td><td align="center" valign="top" rowspan="1" colspan="1">26,918,180</td><td align="center" valign="top" rowspan="1" colspan="1">g</td><td align="center" valign="top" rowspan="1" colspan="1">a</td><td align="center" valign="top" rowspan="1" colspan="1">24%</td><td align="center" valign="top" rowspan="1" colspan="1">0.09 (0.03)</td><td align="center" valign="top" rowspan="1" colspan="1">0.02%</td><td align="center" valign="top" rowspan="1" colspan="1">1.20E-07</td><td align="center" valign="top" rowspan="1" colspan="1">8.24E-04</td><td align="center" valign="top" rowspan="1" colspan="1">198,577</td><td align="center" valign="top" rowspan="1" colspan="1">9.48E-10</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs4836133</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>ZNF608</italic></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">5</td><td align="center" valign="top" rowspan="1" colspan="1">124,360,002</td><td align="center" valign="top" rowspan="1" colspan="1">a</td><td align="center" valign="top" rowspan="1" colspan="1">c</td><td align="center" valign="top" rowspan="1" colspan="1">48%</td><td align="center" valign="top" rowspan="1" colspan="1">0.07 (0.02)</td><td align="center" valign="top" rowspan="1" colspan="1">0.01%</td><td align="center" valign="top" rowspan="1" colspan="1">7.04E-07</td><td align="center" valign="top" rowspan="1" colspan="1">1.88E-04</td><td align="center" valign="top" rowspan="1" colspan="1">241,999</td><td align="center" valign="top" rowspan="1" colspan="1">1.97E-09</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs4929949</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>RPL27A</italic></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>TUB</italic><xref rid="TFN5" ref-type="table-fn">B</xref></td><td align="center" valign="top" rowspan="1" colspan="1">11</td><td align="center" valign="top" rowspan="1" colspan="1">8,561,169</td><td align="center" valign="top" rowspan="1" colspan="1">c</td><td align="center" valign="top" rowspan="1" colspan="1">t</td><td align="center" valign="top" rowspan="1" colspan="1">52%</td><td align="center" valign="top" rowspan="1" colspan="1">0.06 (0.02)</td><td align="center" valign="top" rowspan="1" colspan="1">0.01%</td><td align="center" valign="top" rowspan="1" colspan="1">7.57E-08</td><td align="center" valign="top" rowspan="1" colspan="1">1.00E-03</td><td align="center" valign="top" rowspan="1" colspan="1">249,791</td><td align="center" valign="top" rowspan="1" colspan="1">2.80E-09</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs206936</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>NUDT3</italic></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>HMGA1</italic><xref rid="TFN5" ref-type="table-fn">B</xref></td><td align="center" valign="top" rowspan="1" colspan="1">6</td><td align="center" valign="top" rowspan="1" colspan="1">34,410,847</td><td align="center" valign="top" rowspan="1" colspan="1">g</td><td align="center" valign="top" rowspan="1" colspan="1">a</td><td align="center" valign="top" rowspan="1" colspan="1">21%</td><td align="center" valign="top" rowspan="1" colspan="1">0.06 (0.02)</td><td align="center" valign="top" rowspan="1" colspan="1">0.01%</td><td align="center" valign="top" rowspan="1" colspan="1">2.81E-06</td><td align="center" valign="top" rowspan="1" colspan="1">7.39E-04</td><td align="center" valign="top" rowspan="1" colspan="1">249,777</td><td align="center" valign="top" rowspan="1" colspan="1">3.02E-08</td></tr></tbody></table><table-wrap-foot><fn id="TFN1"><label>*</label><p>Genes within +/− 500 kb of the lead SNP</p></fn><fn id="TFN2"><label>**</label><p>Positions according to Build 36 and allele coding based on the positive
strand</p></fn><fn id="TFN3"><label>***</label><p>Effect sizes in kg/m2 obtained from Stage 2 cohorts only</p></fn><fn id="TFN4"><label>Q</label><p>Association and eQTL data converge to affect gene expression</p></fn><fn id="TFN5"><label>B</label><p>Biological candidate</p></fn><fn id="TFN6"><label>M</label><p>BMI-associated variant is in strong LD (r2 ≥ 0.75) with a
missense variant in the indicated gene</p></fn><fn id="TFN7"><label>C</label><p>CNV</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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