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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">New genetic loci link adipose and insulin biology to body fat distribution</title><author><name sortKey="Shungin, Dmitry" sort="Shungin, Dmitry" uniqKey="Shungin D" first="Dmitry" last="Shungin">Dmitry Shungin</name><affiliation><nlm:aff id="A1">Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå 901 87, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Odontology, Umeå University, Umeå 901 85, Sweden</nlm:aff></affiliation></author><author><name sortKey="Winkler, Thomas W" sort="Winkler, Thomas W" uniqKey="Winkler T" first="Thomas W" last="Winkler">Thomas W. Winkler</name><affiliation><nlm:aff id="A4">Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Croteau Chonka, Damien C" sort="Croteau Chonka, Damien C" uniqKey="Croteau Chonka D" first="Damien C" last="Croteau-Chonka">Damien C. Croteau-Chonka</name><affiliation><nlm:aff id="A5">Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Ferreira, Teresa" sort="Ferreira, Teresa" uniqKey="Ferreira T" first="Teresa" last="Ferreira">Teresa Ferreira</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Locke, Adam E" sort="Locke, Adam E" uniqKey="Locke A" first="Adam E" last="Locke">Adam E. Locke</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA</nlm:aff></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Estonian Genome Center, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Strawbridge, Rona J" sort="Strawbridge, Rona J" uniqKey="Strawbridge R" first="Rona J" last="Strawbridge">Rona J. Strawbridge</name><affiliation><nlm:aff id="A10">Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden</nlm:aff></affiliation></author><author><name sortKey="Pers, Tune H" sort="Pers, Tune H" uniqKey="Pers T" first="Tune H" last="Pers">Tune H. Pers</name><affiliation><nlm:aff id="A11">Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Department of Genetics, Harvard Medical School, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby 2800, Denmark</nlm:aff></affiliation></author><author><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name><affiliation><nlm:aff id="A9">Estonian Genome Center, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Justice, Anne E" sort="Justice, Anne E" uniqKey="Justice A" first="Anne E" last="Justice">Anne E. Justice</name><affiliation><nlm:aff id="A15">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA</nlm:aff></affiliation></author><author><name sortKey="Workalemahu, Tsegaselassie" sort="Workalemahu, Tsegaselassie" uniqKey="Workalemahu T" first="Tsegaselassie" last="Workalemahu">Tsegaselassie Workalemahu</name><affiliation><nlm:aff id="A16">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Wu, Joseph M W" sort="Wu, Joseph M W" uniqKey="Wu J" first="Joseph M. W." last="Wu">Joseph M. W. Wu</name><affiliation><nlm:aff id="A17">Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Buchkovich, Martin L" sort="Buchkovich, Martin L" uniqKey="Buchkovich M" first="Martin L" last="Buchkovich">Martin L. Buchkovich</name><affiliation><nlm:aff id="A5">Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff></affiliation></author><author><name sortKey="Heard Costa, Nancy L" sort="Heard Costa, Nancy L" uniqKey="Heard Costa N" first="Nancy L" last="Heard-Costa">Nancy L. Heard-Costa</name><affiliation><nlm:aff id="A18">National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham MA 01702, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Roman, Tamara S" sort="Roman, Tamara S" uniqKey="Roman T" first="Tamara S" last="Roman">Tamara S. Roman</name><affiliation><nlm:aff id="A5">Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff></affiliation></author><author><name sortKey="Drong, Alexander W" sort="Drong, Alexander W" uniqKey="Drong A" first="Alexander W" last="Drong">Alexander W. Drong</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Song, Ci" sort="Song, Ci" uniqKey="Song C" first="Ci" last="Song">Ci Song</name><affiliation><nlm:aff id="A20">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation></author><author><name sortKey="Gustafsson, Stefan" sort="Gustafsson, Stefan" uniqKey="Gustafsson S" first="Stefan" last="Gustafsson">Stefan Gustafsson</name><affiliation><nlm:aff id="A21">Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation></author><author><name sortKey="Day, Felix R" sort="Day, Felix R" uniqKey="Day F" first="Felix R" last="Day">Felix R. Day</name><affiliation><nlm:aff id="A23">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Esko, Tonu" sort="Esko, Tonu" uniqKey="Esko T" first="Tonu" last="Esko">Tonu Esko</name><affiliation><nlm:aff id="A9">Estonian Genome Center, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Department of Genetics, Harvard Medical School, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Fall, Tove" sort="Fall, Tove" uniqKey="Fall T" first="Tove" last="Fall">Tove Fall</name><affiliation><nlm:aff id="A20">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name><affiliation><nlm:aff id="A24">Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne 1010, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A25">Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Department of Medical Genetics, University of Lausanne, Lausanne 1005, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Luan, Jian N" sort="Luan, Jian N" uniqKey="Luan J" first="Jian N" last="Luan">Jian N Luan</name><affiliation><nlm:aff id="A23">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Randall, Joshua C" sort="Randall, Joshua C" uniqKey="Randall J" first="Joshua C" last="Randall">Joshua C. Randall</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Scherag, Andre" sort="Scherag, Andre" uniqKey="Scherag A" first="André" last="Scherag">André Scherag</name><affiliation><nlm:aff id="A28">Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A29">Clinical Epidemiology, Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Vedantam, Sailaja" sort="Vedantam, Sailaja" uniqKey="Vedantam S" first="Sailaja" last="Vedantam">Sailaja Vedantam</name><affiliation><nlm:aff id="A11">Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Wood, Andrew R" sort="Wood, Andrew R" uniqKey="Wood A" first="Andrew R" last="Wood">Andrew R. Wood</name><affiliation><nlm:aff id="A30">Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK</nlm:aff></affiliation></author><author><name sortKey="Chen, Jin" sort="Chen, Jin" uniqKey="Chen J" first="Jin" last="Chen">Jin Chen</name><affiliation><nlm:aff id="A31">Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA</nlm:aff></affiliation></author><author><name sortKey="Fehrmann, Rudolf" sort="Fehrmann, Rudolf" uniqKey="Fehrmann R" first="Rudolf" last="Fehrmann">Rudolf Fehrmann</name><affiliation><nlm:aff id="A32">Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Karjalainen, Juha" sort="Karjalainen, Juha" uniqKey="Karjalainen J" first="Juha" last="Karjalainen">Juha Karjalainen</name><affiliation><nlm:aff id="A32">Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kahali, Bratati" sort="Kahali, Bratati" uniqKey="Kahali B" first="Bratati" last="Kahali">Bratati Kahali</name><affiliation><nlm:aff id="A33">Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109</nlm:aff></affiliation></author><author><name sortKey="Liu, Ching Ti" sort="Liu, Ching Ti" uniqKey="Liu C" first="Ching-Ti" last="Liu">Ching-Ti Liu</name><affiliation><nlm:aff id="A17">Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Ellen M" sort="Schmidt, Ellen M" uniqKey="Schmidt E" first="Ellen M" last="Schmidt">Ellen M. Schmidt</name><affiliation><nlm:aff id="A34">Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA</nlm:aff></affiliation></author><author><name sortKey="Absher, Devin" sort="Absher, Devin" uniqKey="Absher D" first="Devin" last="Absher">Devin Absher</name><affiliation><nlm:aff id="A35">HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA</nlm:aff></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation><nlm:aff id="A36">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Anderson, Denise" sort="Anderson, Denise" uniqKey="Anderson D" first="Denise" last="Anderson">Denise Anderson</name><affiliation><nlm:aff id="A37">Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Western Australia 6008, Australia</nlm:aff></affiliation></author><author><name sortKey="Beekman, Marian" sort="Beekman, Marian" uniqKey="Beekman M" first="Marian" last="Beekman">Marian Beekman</name><affiliation><nlm:aff id="A38">Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Bragg Gresham, Jennifer L" sort="Bragg Gresham, Jennifer L" uniqKey="Bragg Gresham J" first="Jennifer L" last="Bragg-Gresham">Jennifer L. Bragg-Gresham</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Kidney Epidemiology and Cost Center, University of Michigan, Ann Arbor, MI 48109</nlm:aff></affiliation></author><author><name sortKey="Buyske, Steven" sort="Buyske, Steven" uniqKey="Buyske S" first="Steven" last="Buyske">Steven Buyske</name><affiliation><nlm:aff id="A41">Department of Statistics & Biostatistics, Rutgers University, Piscataway, NJ USA</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Department of Genetics, Rutgers University, Piscataway, NJ USA</nlm:aff></affiliation></author><author><name sortKey="Demirkan, Ayse" sort="Demirkan, Ayse" uniqKey="Demirkan A" first="Ayse" last="Demirkan">Ayse Demirkan</name><affiliation><nlm:aff id="A36">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Department of Human Genetics, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Ehret, Georg B" sort="Ehret, Georg B" uniqKey="Ehret G" first="Georg B" last="Ehret">Georg B. Ehret</name><affiliation><nlm:aff id="A44">Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A45">Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva 1211, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Feitosa, Mary F" sort="Feitosa, Mary F" uniqKey="Feitosa M" first="Mary F" last="Feitosa">Mary F. Feitosa</name><affiliation><nlm:aff id="A46">Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A47">Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK</nlm:aff></affiliation></author><author><name sortKey="Jackson, Anne U" sort="Jackson, Anne U" uniqKey="Jackson A" first="Anne U" last="Jackson">Anne U. Jackson</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name><affiliation><nlm:aff id="A25">Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Department of Medical Genetics, University of Lausanne, Lausanne 1005, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A48">University Institute for Social and Preventative Medecine, Centre Hospitalier Universitaire Vaudois (CHUV), University of Lausanne, Lausanne 1005, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E" last="Kleber">Marcus E. Kleber</name><affiliation><nlm:aff id="A49">Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A50">Department of Internal Medicine II, Ulm University Medical Centre, D-89081 Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Kristiansson, Kati" sort="Kristiansson, Kati" uniqKey="Kristiansson K" first="Kati" last="Kristiansson">Kati Kristiansson</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation><nlm:aff id="A52">Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Leach, Irene Mateo" sort="Leach, Irene Mateo" uniqKey="Leach I" first="Irene Mateo" last="Leach">Irene Mateo Leach</name><affiliation><nlm:aff id="A53">Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Medina Gomez, Carolina" sort="Medina Gomez, Carolina" uniqKey="Medina Gomez C" first="Carolina" last="Medina-Gomez">Carolina Medina-Gomez</name><affiliation><nlm:aff id="A54">Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Palmer, Cameron D" sort="Palmer, Cameron D" uniqKey="Palmer C" first="Cameron D" last="Palmer">Cameron D. Palmer</name><affiliation><nlm:aff id="A11">Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Pasko, Dorota" sort="Pasko, Dorota" uniqKey="Pasko D" first="Dorota" last="Pasko">Dorota Pasko</name><affiliation><nlm:aff id="A30">Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK</nlm:aff></affiliation></author><author><name sortKey="Pechlivanis, Sonali" sort="Pechlivanis, Sonali" uniqKey="Pechlivanis S" first="Sonali" last="Pechlivanis">Sonali Pechlivanis</name><affiliation><nlm:aff id="A28">Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Peters, Marjolein J" sort="Peters, Marjolein J" uniqKey="Peters M" first="Marjolein J" last="Peters">Marjolein J. Peters</name><affiliation><nlm:aff id="A54">Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A58">Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Stan Kova, Alena" sort="Stan Kova, Alena" uniqKey="Stan Kova A" first="Alena" last="Stan Ková">Alena Stan Ková</name><affiliation><nlm:aff id="A59">University of Eastern Finland, FI-70210 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Sung, Yun Ju" sort="Sung, Yun Ju" uniqKey="Sung Y" first="Yun Ju" last="Sung">Yun Ju Sung</name><affiliation><nlm:aff id="A60">Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation><nlm:aff id="A61">Translational Gerontology Branch, National Institute on Aging, Baltimore MD 21225, USA</nlm:aff></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:aff id="A62">Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Van Vliet Ostaptchouk, Jana V" sort="Van Vliet Ostaptchouk, Jana V" uniqKey="Van Vliet Ostaptchouk J" first="Jana V" last="Van Vliet-Ostaptchouk">Jana V. Van Vliet-Ostaptchouk</name><affiliation><nlm:aff id="A63">Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Yengo, Loic" sort="Yengo, Loic" uniqKey="Yengo L" first="Loïc" last="Yengo">Loïc Yengo</name><affiliation><nlm:aff id="A64">CNRS UMR 8199, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A65">European Genomic Institute for Diabetes, F-59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Université de Lille 2, F-59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><affiliation><nlm:aff id="A67">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Albrecht, Eva" sort="Albrecht, Eva" uniqKey="Albrecht E" first="Eva" last="Albrecht">Eva Albrecht</name><affiliation><nlm:aff id="A69">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey=" Rnlov, Johan" sort=" Rnlov, Johan" uniqKey=" Rnlov J" first="Johan" last=" Rnlöv">Johan Rnlöv</name><affiliation><nlm:aff id="A21">Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A70">School of Health and Social Studies, Dalarna University, Falun, Sweden</nlm:aff></affiliation></author><author><name sortKey="Arscott, Gillian M" sort="Arscott, Gillian M" uniqKey="Arscott G" first="Gillian M" last="Arscott">Gillian M. Arscott</name><affiliation><nlm:aff id="A71">PathWest Laboratory Medicine of Western Australia, NEDLANDS, Western Australia 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name><affiliation><nlm:aff id="A72">Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Barrett, Amy" sort="Barrett, Amy" uniqKey="Barrett A" first="Amy" last="Barrett">Amy Barrett</name><affiliation><nlm:aff id="A57">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Bellis, Claire" sort="Bellis, Claire" uniqKey="Bellis C" first="Claire" last="Bellis">Claire Bellis</name><affiliation><nlm:aff id="A73">Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A74">Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Bennett, Amanda J" sort="Bennett, Amanda J" uniqKey="Bennett A" first="Amanda J" last="Bennett">Amanda J. Bennett</name><affiliation><nlm:aff id="A57">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Berne, Christian" sort="Berne, Christian" uniqKey="Berne C" first="Christian" last="Berne">Christian Berne</name><affiliation><nlm:aff id="A75">Department of Medical Sciences, Endocrinology, Diabetes and Metabolism, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation></author><author><name sortKey="Bluher, Matthias" sort="Bluher, Matthias" uniqKey="Bluher M" first="Matthias" last="Blüher">Matthias Blüher</name><affiliation><nlm:aff id="A76">Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Bohringer, Stefan" sort="Bohringer, Stefan" uniqKey="Bohringer S" first="Stefan" last="Böhringer">Stefan Böhringer</name><affiliation><nlm:aff id="A38">Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A78">Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Bonnet, Fabrice" sort="Bonnet, Fabrice" uniqKey="Bonnet F" first="Fabrice" last="Bonnet">Fabrice Bonnet</name><affiliation><nlm:aff id="A79">Inserm UMR991, Department of Endocrinology, University of Rennes, F-35000 Rennes, France</nlm:aff></affiliation></author><author><name sortKey="Bottcher, Yvonne" sort="Bottcher, Yvonne" uniqKey="Bottcher Y" first="Yvonne" last="Böttcher">Yvonne Böttcher</name><affiliation><nlm:aff id="A76">Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Bruinenberg, Marcel" sort="Bruinenberg, Marcel" uniqKey="Bruinenberg M" first="Marcel" last="Bruinenberg">Marcel Bruinenberg</name><affiliation><nlm:aff id="A80">LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Carba, Delia B" sort="Carba, Delia B" uniqKey="Carba D" first="Delia B" last="Carba">Delia B. Carba</name><affiliation><nlm:aff id="A81">USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines</nlm:aff></affiliation></author><author><name sortKey="Caspersen, Ida H" sort="Caspersen, Ida H" uniqKey="Caspersen I" first="Ida H" last="Caspersen">Ida H. Caspersen</name><affiliation><nlm:aff id="A82">Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway</nlm:aff></affiliation></author><author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name><affiliation><nlm:aff id="A83">Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK</nlm:aff></affiliation></author><author><name sortKey="Daw, E Warwick" sort="Daw, E Warwick" uniqKey="Daw E" first="E Warwick" last="Daw">E Warwick Daw</name><affiliation><nlm:aff id="A46">Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Deelen, Joris" sort="Deelen, Joris" uniqKey="Deelen J" first="Joris" last="Deelen">Joris Deelen</name><affiliation><nlm:aff id="A38">Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Deelman, Ewa" sort="Deelman, Ewa" uniqKey="Deelman E" first="Ewa" last="Deelman">Ewa Deelman</name><affiliation><nlm:aff id="A84">Information Sciences Institute, University of Southern California, Marina del Rey, California, USA</nlm:aff></affiliation></author><author><name sortKey="Delgado, Graciela" sort="Delgado, Graciela" uniqKey="Delgado G" first="Graciela" last="Delgado">Graciela Delgado</name><affiliation><nlm:aff id="A49">Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Doney, Alex Sf" sort="Doney, Alex Sf" uniqKey="Doney A" first="Alex Sf" last="Doney">Alex Sf Doney</name><affiliation><nlm:aff id="A85">Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK</nlm:aff></affiliation></author><author><name sortKey="Eklund, Niina" sort="Eklund, Niina" uniqKey="Eklund N" first="Niina" last="Eklund">Niina Eklund</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A86">Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Erdos, Michael R" sort="Erdos, Michael R" uniqKey="Erdos M" first="Michael R" last="Erdos">Michael R. Erdos</name><affiliation><nlm:aff id="A87">Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Estrada, Karol" sort="Estrada, Karol" uniqKey="Estrada K" first="Karol" last="Estrada">Karol Estrada</name><affiliation><nlm:aff id="A12">Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A88">Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Eury, Elodie" sort="Eury, Elodie" uniqKey="Eury E" first="Elodie" last="Eury">Elodie Eury</name><affiliation><nlm:aff id="A64">CNRS UMR 8199, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A65">European Genomic Institute for Diabetes, F-59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Université de Lille 2, F-59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Friedrich, Nele" sort="Friedrich, Nele" uniqKey="Friedrich N" first="Nele" last="Friedrich">Nele Friedrich</name><affiliation><nlm:aff id="A89">Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Garcia, Melissa E" sort="Garcia, Melissa E" uniqKey="Garcia M" first="Melissa E" last="Garcia">Melissa E. Garcia</name><affiliation><nlm:aff id="A90">Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Giedraitis, Vilmantas" sort="Giedraitis, Vilmantas" uniqKey="Giedraitis V" first="Vilmantas" last="Giedraitis">Vilmantas Giedraitis</name><affiliation><nlm:aff id="A91">Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation></author><author><name sortKey="Gigante, Bruna" sort="Gigante, Bruna" uniqKey="Gigante B" first="Bruna" last="Gigante">Bruna Gigante</name><affiliation><nlm:aff id="A92">Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Go, Alan S" sort="Go, Alan S" uniqKey="Go A" first="Alan S" last="Go">Alan S. Go</name><affiliation><nlm:aff id="A93">Kaiser Permanente, Division of Research, Oakland, CA 94612, USA</nlm:aff></affiliation></author><author><name sortKey="Golay, Alain" sort="Golay, Alain" uniqKey="Golay A" first="Alain" last="Golay">Alain Golay</name><affiliation><nlm:aff id="A94">Service of Therapeutic Education for Diabetes, Obesity and Chronic Diseases, Geneva University Hospital, Geneva CH-1211, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Grallert, Harald" sort="Grallert, Harald" uniqKey="Grallert H" first="Harald" last="Grallert">Harald Grallert</name><affiliation><nlm:aff id="A69">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A95">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A96">German Center for Diabetes Research (DZD), Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Grammer, Tanja B" sort="Grammer, Tanja B" uniqKey="Grammer T" first="Tanja B" last="Grammer">Tanja B. Grammer</name><affiliation><nlm:aff id="A49">Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Gr Ler, Jurgen" sort="Gr Ler, Jurgen" uniqKey="Gr Ler J" first="Jürgen" last="Gr Ler">Jürgen Gr Ler</name><affiliation><nlm:aff id="A97">Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Grewal, Jagvir" sort="Grewal, Jagvir" uniqKey="Grewal J" first="Jagvir" last="Grewal">Jagvir Grewal</name><affiliation><nlm:aff id="A67">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Groves, Christopher J" sort="Groves, Christopher J" uniqKey="Groves C" first="Christopher J" last="Groves">Christopher J. Groves</name><affiliation><nlm:aff id="A57">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Haller, Toomas" sort="Haller, Toomas" uniqKey="Haller T" first="Toomas" last="Haller">Toomas Haller</name><affiliation><nlm:aff id="A9">Estonian Genome Center, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Hallmans, Goran" sort="Hallmans, Goran" uniqKey="Hallmans G" first="Goran" last="Hallmans">Goran Hallmans</name><affiliation><nlm:aff id="A98">Department of Public Health and Clinical Medicine, Unit of Nutritional Research, Umeå University, Umeå 90187, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hartman, Catharina A" sort="Hartman, Catharina A" uniqKey="Hartman C" first="Catharina A" last="Hartman">Catharina A. Hartman</name><affiliation><nlm:aff id="A99">Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hassinen, Maija" sort="Hassinen, Maija" uniqKey="Hassinen M" first="Maija" last="Hassinen">Maija Hassinen</name><affiliation><nlm:aff id="A100">Kuopio Research Institute of Exercise Medicine, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="A101">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, Scotland, UK</nlm:aff></affiliation></author><author><name sortKey="Heikkil, Kauko" sort="Heikkil, Kauko" uniqKey="Heikkil K" first="Kauko" last="Heikkil">Kauko Heikkil</name><affiliation><nlm:aff id="A102">Hjelt Institute Department of Public Health, University of Helsinki, FI-00014 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Herzig, Karl Heinz" sort="Herzig, Karl Heinz" uniqKey="Herzig K" first="Karl-Heinz" last="Herzig">Karl-Heinz Herzig</name><affiliation><nlm:aff id="A103">Institute of Biomedicine, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A104">Medical Research Center Oulu and Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A105">Biocenter Oulu, University of Oulu, FI-90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Helmer, Quinta" sort="Helmer, Quinta" uniqKey="Helmer Q" first="Quinta" last="Helmer">Quinta Helmer</name><affiliation><nlm:aff id="A38">Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A78">Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A106">Faculty of Psychology and Education, VU University Amsterdam, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hillege, Hans L" sort="Hillege, Hans L" uniqKey="Hillege H" first="Hans L" last="Hillege">Hans L. Hillege</name><affiliation><nlm:aff id="A53">Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A107">Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Holmen, Oddgeir" sort="Holmen, Oddgeir" uniqKey="Holmen O" first="Oddgeir" last="Holmen">Oddgeir Holmen</name><affiliation><nlm:aff id="A108">Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim 7489, Norway</nlm:aff></affiliation></author><author><name sortKey="Hunt, Steven C" sort="Hunt, Steven C" uniqKey="Hunt S" first="Steven C" last="Hunt">Steven C. Hunt</name><affiliation><nlm:aff id="A109">Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84108, USA</nlm:aff></affiliation></author><author><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name><affiliation><nlm:aff id="A36">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A110">Center for Medical Sytems Biology, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Ittermann, Till" sort="Ittermann, Till" uniqKey="Ittermann T" first="Till" last="Ittermann">Till Ittermann</name><affiliation><nlm:aff id="A111">Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="James, Alan L" sort="James, Alan L" uniqKey="James A" first="Alan L" last="James">Alan L. James</name><affiliation><nlm:aff id="A112">Department of Pulmonary Physiology and Sleep Medicine, Nedlands, Western Australia 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A113">School of Medicine and Pharmacology, University of Western Australia, Crawley 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="Johansson, Ingegerd" sort="Johansson, Ingegerd" uniqKey="Johansson I" first="Ingegerd" last="Johansson">Ingegerd Johansson</name><affiliation><nlm:aff id="A3">Department of Odontology, Umeå University, Umeå 901 85, Sweden</nlm:aff></affiliation></author><author><name sortKey="Juliusdottir, Thorhildur" sort="Juliusdottir, Thorhildur" uniqKey="Juliusdottir T" first="Thorhildur" last="Juliusdottir">Thorhildur Juliusdottir</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Kalafati, Ioanna Panagiota" sort="Kalafati, Ioanna Panagiota" uniqKey="Kalafati I" first="Ioanna-Panagiota" last="Kalafati">Ioanna-Panagiota Kalafati</name><affiliation><nlm:aff id="A114">Department of Dietetics-Nutrition, Harokopio University, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Kinnunen, Leena" sort="Kinnunen, Leena" uniqKey="Kinnunen L" first="Leena" last="Kinnunen">Leena Kinnunen</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name><affiliation><nlm:aff id="A50">Department of Internal Medicine II, Ulm University Medical Centre, D-89081 Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Kooner, Ishminder K" sort="Kooner, Ishminder K" uniqKey="Kooner I" first="Ishminder K" last="Kooner">Ishminder K. Kooner</name><affiliation><nlm:aff id="A67">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff></affiliation></author><author><name sortKey="Kratzer, Wolfgang" sort="Kratzer, Wolfgang" uniqKey="Kratzer W" first="Wolfgang" last="Kratzer">Wolfgang Kratzer</name><affiliation><nlm:aff id="A115">Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Lamina, Claudia" sort="Lamina, Claudia" uniqKey="Lamina C" first="Claudia" last="Lamina">Claudia Lamina</name><affiliation><nlm:aff id="A116">Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria</nlm:aff></affiliation></author><author><name sortKey="Leander, Karin" sort="Leander, Karin" uniqKey="Leander K" first="Karin" last="Leander">Karin Leander</name><affiliation><nlm:aff id="A92">Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lee, Nanette R" sort="Lee, Nanette R" uniqKey="Lee N" first="Nanette R" last="Lee">Nanette R. Lee</name><affiliation><nlm:aff id="A81">USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines</nlm:aff></affiliation></author><author><name sortKey="Lichtner, Peter" sort="Lichtner, Peter" uniqKey="Lichtner P" first="Peter" last="Lichtner">Peter Lichtner</name><affiliation><nlm:aff id="A117">Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation><nlm:aff id="A118">Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Jaana" sort="Lindstrom, Jaana" uniqKey="Lindstrom J" first="Jaana" last="Lindström">Jaana Lindström</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Lobbens, Stephane" sort="Lobbens, Stephane" uniqKey="Lobbens S" first="Stéphane" last="Lobbens">Stéphane Lobbens</name><affiliation><nlm:aff id="A64">CNRS UMR 8199, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A65">European Genomic Institute for Diabetes, F-59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Université de Lille 2, F-59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Lorentzon, Mattias" sort="Lorentzon, Mattias" uniqKey="Lorentzon M" first="Mattias" last="Lorentzon">Mattias Lorentzon</name><affiliation><nlm:aff id="A119">Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden</nlm:aff></affiliation></author><author><name sortKey="Mach, Francois" sort="Mach, Francois" uniqKey="Mach F" first="François" last="Mach">François Mach</name><affiliation><nlm:aff id="A45">Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva 1211, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Magnusson, Patrik Ke" sort="Magnusson, Patrik Ke" uniqKey="Magnusson P" first="Patrik Ke" last="Magnusson">Patrik Ke Magnusson</name><affiliation><nlm:aff id="A20">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Mahajan, Anubha" sort="Mahajan, Anubha" uniqKey="Mahajan A" first="Anubha" last="Mahajan">Anubha Mahajan</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L" last="Mcardle">Wendy L. Mcardle</name><affiliation><nlm:aff id="A120">School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Menni, Cristina" sort="Menni, Cristina" uniqKey="Menni C" first="Cristina" last="Menni">Cristina Menni</name><affiliation><nlm:aff id="A52">Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Merger, Sigrun" sort="Merger, Sigrun" uniqKey="Merger S" first="Sigrun" last="Merger">Sigrun Merger</name><affiliation><nlm:aff id="A121">Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Mihailov, Evelin" sort="Mihailov, Evelin" uniqKey="Mihailov E" first="Evelin" last="Mihailov">Evelin Mihailov</name><affiliation><nlm:aff id="A9">Estonian Genome Center, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A122">Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Milani, Lili" sort="Milani, Lili" uniqKey="Milani L" first="Lili" last="Milani">Lili Milani</name><affiliation><nlm:aff id="A9">Estonian Genome Center, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Mills, Rebecca" sort="Mills, Rebecca" uniqKey="Mills R" first="Rebecca" last="Mills">Rebecca Mills</name><affiliation><nlm:aff id="A67">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff></affiliation></author><author><name sortKey="Moayyeri, Alireza" sort="Moayyeri, Alireza" uniqKey="Moayyeri A" first="Alireza" last="Moayyeri">Alireza Moayyeri</name><affiliation><nlm:aff id="A52">Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A123">Farr Institute of Health Informatics Research, University College London, London NW1 2DA, UK</nlm:aff></affiliation></author><author><name sortKey="Monda, Keri L" sort="Monda, Keri L" uniqKey="Monda K" first="Keri L" last="Monda">Keri L. Monda</name><affiliation><nlm:aff id="A15">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A124">The Center for Observational Research, Amgen, Inc., Thousand Oaks, CA 91320, USA</nlm:aff></affiliation></author><author><name sortKey="Mooijaart, Simon P" sort="Mooijaart, Simon P" uniqKey="Mooijaart S" first="Simon P" last="Mooijaart">Simon P. Mooijaart</name><affiliation><nlm:aff id="A38">Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A125">Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W" last="Mühleisen">Thomas W. Mühleisen</name><affiliation><nlm:aff id="A126">Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A127">Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Mulas, Antonella" sort="Mulas, Antonella" uniqKey="Mulas A" first="Antonella" last="Mulas">Antonella Mulas</name><affiliation><nlm:aff id="A128">Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Sardinia 09042, Italy</nlm:aff></affiliation></author><author><name sortKey="Muller, Gabriele" sort="Muller, Gabriele" uniqKey="Muller G" first="Gabriele" last="Müller">Gabriele Müller</name><affiliation><nlm:aff id="A129">Center for Evidence-based Healthcare, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name><affiliation><nlm:aff id="A69">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A130">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, D-81377 Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A131">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, D-81377 Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A132">Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Nagaraja, Ramaiah" sort="Nagaraja, Ramaiah" uniqKey="Nagaraja R" first="Ramaiah" last="Nagaraja">Ramaiah Nagaraja</name><affiliation><nlm:aff id="A133">Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA</nlm:aff></affiliation></author><author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A" last="Nalls">Michael A. Nalls</name><affiliation><nlm:aff id="A134">Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Narisu, Narisu" sort="Narisu, Narisu" uniqKey="Narisu N" first="Narisu" last="Narisu">Narisu Narisu</name><affiliation><nlm:aff id="A87">Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Glorioso, Nicola" sort="Glorioso, Nicola" uniqKey="Glorioso N" first="Nicola" last="Glorioso">Nicola Glorioso</name><affiliation><nlm:aff id="A135">Hypertension and Related Diseases Centre - AOU, University of Sassari Medical School, Sassari 07100, Italy</nlm:aff></affiliation></author><author><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M" last="Nolte">Ilja M. Nolte</name><affiliation><nlm:aff id="A107">Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Olden, Matthias" sort="Olden, Matthias" uniqKey="Olden M" first="Matthias" last="Olden">Matthias Olden</name><affiliation><nlm:aff id="A4">Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Rayner, Nigel W" sort="Rayner, Nigel W" uniqKey="Rayner N" first="Nigel W" last="Rayner">Nigel W. Rayner</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Renstrom, Frida" sort="Renstrom, Frida" uniqKey="Renstrom F" first="Frida" last="Renstrom">Frida Renstrom</name><affiliation><nlm:aff id="A2">Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden</nlm:aff></affiliation></author><author><name sortKey="Ried, Janina S" sort="Ried, Janina S" uniqKey="Ried J" first="Janina S" last="Ried">Janina S. Ried</name><affiliation><nlm:aff id="A69">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Robertson, Neil R" sort="Robertson, Neil R" uniqKey="Robertson N" first="Neil R" last="Robertson">Neil R. Robertson</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Rose, Lynda M" sort="Rose, Lynda M" uniqKey="Rose L" first="Lynda M" last="Rose">Lynda M. Rose</name><affiliation><nlm:aff id="A136">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA 02215, USA</nlm:aff></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation><nlm:aff id="A128">Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Sardinia 09042, Italy</nlm:aff></affiliation></author><author><name sortKey="Scharnagl, Hubert" sort="Scharnagl, Hubert" uniqKey="Scharnagl H" first="Hubert" last="Scharnagl">Hubert Scharnagl</name><affiliation><nlm:aff id="A137">Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria</nlm:aff></affiliation></author><author><name sortKey="Scholtens, Salome" sort="Scholtens, Salome" uniqKey="Scholtens S" first="Salome" last="Scholtens">Salome Scholtens</name><affiliation><nlm:aff id="A80">LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Sennblad, Bengt" sort="Sennblad, Bengt" uniqKey="Sennblad B" first="Bengt" last="Sennblad">Bengt Sennblad</name><affiliation><nlm:aff id="A10">Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A138">Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Seufferlein, Thomas" sort="Seufferlein, Thomas" uniqKey="Seufferlein T" first="Thomas" last="Seufferlein">Thomas Seufferlein</name><affiliation><nlm:aff id="A115">Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Sitlani, Colleen M" sort="Sitlani, Colleen M" uniqKey="Sitlani C" first="Colleen M" last="Sitlani">Colleen M. Sitlani</name><affiliation><nlm:aff id="A139">Department of Medicine, University of Washington, Seattle, WA 98101, USA</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name><affiliation><nlm:aff id="A140">Icelandic Heart Association, Kopavogur 201, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A141">University of Iceland, Reykjavik 101, Iceland</nlm:aff></affiliation></author><author><name sortKey="Stirrups, Kathleen" sort="Stirrups, Kathleen" uniqKey="Stirrups K" first="Kathleen" last="Stirrups">Kathleen Stirrups</name><affiliation><nlm:aff id="A27">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A142">William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ UK</nlm:aff></affiliation></author><author><name sortKey="Stringham, Heather M" sort="Stringham, Heather M" uniqKey="Stringham H" first="Heather M" last="Stringham">Heather M. Stringham</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Sundstrom, Johan" sort="Sundstrom, Johan" uniqKey="Sundstrom J" first="Johan" last="Sundström">Johan Sundström</name><affiliation><nlm:aff id="A118">Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation></author><author><name sortKey="Swertz, Morris A" sort="Swertz, Morris A" uniqKey="Swertz M" first="Morris A" last="Swertz">Morris A. Swertz</name><affiliation><nlm:aff id="A32">Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Swift, Amy J" sort="Swift, Amy J" uniqKey="Swift A" first="Amy J" last="Swift">Amy J. Swift</name><affiliation><nlm:aff id="A87">Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Syv Nen, Ann Christine" sort="Syv Nen, Ann Christine" uniqKey="Syv Nen A" first="Ann-Christine" last="Syv Nen">Ann-Christine Syv Nen</name><affiliation><nlm:aff id="A21">Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A143">Department of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala 75144, Sweden</nlm:aff></affiliation></author><author><name sortKey="Tayo, Bamidele O" sort="Tayo, Bamidele O" uniqKey="Tayo B" first="Bamidele O" last="Tayo">Bamidele O. Tayo</name><affiliation><nlm:aff id="A144">Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, IL 61053, USA</nlm:aff></affiliation></author><author><name sortKey="Thorand, Barbara" sort="Thorand, Barbara" uniqKey="Thorand B" first="Barbara" last="Thorand">Barbara Thorand</name><affiliation><nlm:aff id="A96">German Center for Diabetes Research (DZD), Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A145">Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation><nlm:aff id="A146">deCODE Genetics, Amgen inc., Reykjavik 101, Iceland</nlm:aff></affiliation></author><author><name sortKey="Tomaschitz, Andreas" sort="Tomaschitz, Andreas" uniqKey="Tomaschitz A" first="Andreas" last="Tomaschitz">Andreas Tomaschitz</name><affiliation><nlm:aff id="A147">Department of Cardiology, Medical University of Graz, Graz 8036, Austria</nlm:aff></affiliation></author><author><name sortKey="Troffa, Chiara" sort="Troffa, Chiara" uniqKey="Troffa C" first="Chiara" last="Troffa">Chiara Troffa</name><affiliation><nlm:aff id="A135">Hypertension and Related Diseases Centre - AOU, University of Sassari Medical School, Sassari 07100, Italy</nlm:aff></affiliation></author><author><name sortKey="Van Oort, Floor Va" sort="Van Oort, Floor Va" uniqKey="Van Oort F" first="Floor Va" last="Van Oort">Floor Va Van Oort</name><affiliation><nlm:aff id="A148">Department of Child and Adolescent Psychiatry, Psychology, Erasmus MC University Medical Centre, 3000 CB Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name><affiliation><nlm:aff id="A53">Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Vonk, Judith M" sort="Vonk, Judith M" uniqKey="Vonk J" first="Judith M" last="Vonk">Judith M. Vonk</name><affiliation><nlm:aff id="A107">Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Waite, Lindsay L" sort="Waite, Lindsay L" uniqKey="Waite L" first="Lindsay L" last="Waite">Lindsay L. Waite</name><affiliation><nlm:aff id="A35">HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA</nlm:aff></affiliation></author><author><name sortKey="Wennauer, Roman" sort="Wennauer, Roman" uniqKey="Wennauer R" first="Roman" last="Wennauer">Roman Wennauer</name><affiliation><nlm:aff id="A149">Department of Clinical Chemistry, Ulm University Medical Centre, D-89081 Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Wilsgaard, Tom" sort="Wilsgaard, Tom" uniqKey="Wilsgaard T" first="Tom" last="Wilsgaard">Tom Wilsgaard</name><affiliation><nlm:aff id="A150">Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway</nlm:aff></affiliation></author><author><name sortKey="Wojczynski, Mary K" sort="Wojczynski, Mary K" uniqKey="Wojczynski M" first="Mary K" last="Wojczynski">Mary K. Wojczynski</name><affiliation><nlm:aff id="A46">Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Wong, Andrew" sort="Wong, Andrew" uniqKey="Wong A" first="Andrew" last="Wong">Andrew Wong</name><affiliation><nlm:aff id="A151">MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK</nlm:aff></affiliation></author><author><name sortKey="Zhang, Qunyuan" sort="Zhang, Qunyuan" uniqKey="Zhang Q" first="Qunyuan" last="Zhang">Qunyuan Zhang</name><affiliation><nlm:aff id="A46">Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="A23">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Brennan, Eoin P" sort="Brennan, Eoin P" uniqKey="Brennan E" first="Eoin P." last="Brennan">Eoin P. Brennan</name><affiliation><nlm:aff id="A152">Diabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland</nlm:aff></affiliation></author><author><name sortKey="Choi, Murim" sort="Choi, Murim" uniqKey="Choi M" first="Murim" last="Choi">Murim Choi</name><affiliation><nlm:aff id="A153">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Per" sort="Eriksson, Per" uniqKey="Eriksson P" first="Per" last="Eriksson">Per Eriksson</name><affiliation><nlm:aff id="A10">Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden</nlm:aff></affiliation></author><author><name sortKey="Folkersen, Lasse" sort="Folkersen, Lasse" uniqKey="Folkersen L" first="Lasse" last="Folkersen">Lasse Folkersen</name><affiliation><nlm:aff id="A10">Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden</nlm:aff></affiliation></author><author><name sortKey="Franco Cereceda, Anders" sort="Franco Cereceda, Anders" uniqKey="Franco Cereceda A" first="Anders" last="Franco-Cereceda">Anders Franco-Cereceda</name><affiliation><nlm:aff id="A154">Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17176, Sweden</nlm:aff></affiliation></author><author><name sortKey="Gharavi, Ali G" sort="Gharavi, Ali G" uniqKey="Gharavi A" first="Ali G" last="Gharavi">Ali G. Gharavi</name><affiliation><nlm:aff id="A155">Department of Medicine, Columbia University College of Physicians and Surgeons, New York NY, USA</nlm:aff></affiliation></author><author><name sortKey="Hedman, Sa K" sort="Hedman, Sa K" uniqKey="Hedman " first=" Sa K" last="Hedman"> Sa K. Hedman</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hivert, Marie France" sort="Hivert, Marie France" uniqKey="Hivert M" first="Marie-France" last="Hivert">Marie-France Hivert</name><affiliation><nlm:aff id="A156">Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, MA</nlm:aff></affiliation><affiliation><nlm:aff id="A157">Massachusetts General Hospital, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Huang, Jinyan" sort="Huang, Jinyan" uniqKey="Huang J" first="Jinyan" last="Huang">Jinyan Huang</name><affiliation><nlm:aff id="A158">State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China</nlm:aff></affiliation><affiliation><nlm:aff id="A159">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Kanoni, Stavroula" sort="Kanoni, Stavroula" uniqKey="Kanoni S" first="Stavroula" last="Kanoni">Stavroula Kanoni</name><affiliation><nlm:aff id="A142">William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ UK</nlm:aff></affiliation></author><author><name sortKey="Karpe, Fredrik" sort="Karpe, Fredrik" uniqKey="Karpe F" first="Fredrik" last="Karpe">Fredrik Karpe</name><affiliation><nlm:aff id="A57">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A160">NIHR Oxford Biomedical Research Centre, OUH Trust, Oxford OX3 7LE, UK</nlm:aff></affiliation></author><author><name sortKey="Keildson, Sarah" sort="Keildson, Sarah" uniqKey="Keildson S" first="Sarah" last="Keildson">Sarah Keildson</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Kiryluk, Krzysztof" sort="Kiryluk, Krzysztof" uniqKey="Kiryluk K" first="Krzysztof" last="Kiryluk">Krzysztof Kiryluk</name><affiliation><nlm:aff id="A155">Department of Medicine, Columbia University College of Physicians and Surgeons, New York NY, USA</nlm:aff></affiliation></author><author><name sortKey="Liang, Liming" sort="Liang, Liming" uniqKey="Liang L" first="Liming" last="Liang">Liming Liang</name><affiliation><nlm:aff id="A159">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A161">Harvard School of Public Health, Department of Biostatistics, Harvard University, Boston, MA 2115, USA</nlm:aff></affiliation></author><author><name sortKey="Lifton, Richard P" sort="Lifton, Richard P" uniqKey="Lifton R" first="Richard P" last="Lifton">Richard P. Lifton</name><affiliation><nlm:aff id="A162">Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, New Haven CT, USA</nlm:aff></affiliation></author><author><name sortKey="Ma, Baoshan" sort="Ma, Baoshan" uniqKey="Ma B" first="Baoshan" last="Ma">Baoshan Ma</name><affiliation><nlm:aff id="A159">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A163">College of Information Science and Technology, Dalian Maritime University, Dalian, Liaoning 116026, China</nlm:aff></affiliation></author><author><name sortKey="Mcknight, Amy J" sort="Mcknight, Amy J" uniqKey="Mcknight A" first="Amy J" last="Mcknight">Amy J. Mcknight</name><affiliation><nlm:aff id="A164">Nephrology Research, Centre for Public Health, Queen’s University of Belfast, Belfast, Co. Down BT9 7AB, UK</nlm:aff></affiliation></author><author><name sortKey="Mcpherson, Ruth" sort="Mcpherson, Ruth" uniqKey="Mcpherson R" first="Ruth" last="Mcpherson">Ruth Mcpherson</name><affiliation><nlm:aff id="A165">University of Ottawa Heart Institute, Ottawa K1Y 4W7, Canada</nlm:aff></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation><nlm:aff id="A9">Estonian Genome Center, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A122">Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Min, Josine L" sort="Min, Josine L" uniqKey="Min J" first="Josine L" last="Min">Josine L. Min</name><affiliation><nlm:aff id="A120">School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Moffatt, Miriam F" sort="Moffatt, Miriam F" uniqKey="Moffatt M" first="Miriam F" last="Moffatt">Miriam F. Moffatt</name><affiliation><nlm:aff id="A166">National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK</nlm:aff></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W" last="Montgomery">Grant W. Montgomery</name><affiliation><nlm:aff id="A167">QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Murabito, Joanne M" sort="Murabito, Joanne M" uniqKey="Murabito J" first="Joanne M" last="Murabito">Joanne M. Murabito</name><affiliation><nlm:aff id="A18">National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham MA 01702, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A168">Section of General Internal Medicine, Boston University School of Medicine, Boston, MA 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Nicholson, George" sort="Nicholson, George" uniqKey="Nicholson G" first="George" last="Nicholson">George Nicholson</name><affiliation><nlm:aff id="A169">Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A170">MRC Harwell, Harwell Science and Innovation Campus, Harwell, UK</nlm:aff></affiliation></author><author><name sortKey="Nyholt, Dale R" sort="Nyholt, Dale R" uniqKey="Nyholt D" first="Dale R" last="Nyholt">Dale R. Nyholt</name><affiliation><nlm:aff id="A167">QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A171">Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia</nlm:aff></affiliation></author><author><name sortKey="Olsson, Christian" sort="Olsson, Christian" uniqKey="Olsson C" first="Christian" last="Olsson">Christian Olsson</name><affiliation><nlm:aff id="A154">Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17176, Sweden</nlm:aff></affiliation></author><author><name sortKey="Perry, John Rb" sort="Perry, John Rb" uniqKey="Perry J" first="John Rb" last="Perry">John Rb Perry</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Reinmaa, Eva" sort="Reinmaa, Eva" uniqKey="Reinmaa E" first="Eva" last="Reinmaa">Eva Reinmaa</name><affiliation><nlm:aff id="A9">Estonian Genome Center, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Salem, Rany M" sort="Salem, Rany M" uniqKey="Salem R" first="Rany M" last="Salem">Rany M. Salem</name><affiliation><nlm:aff id="A11">Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Department of Genetics, Harvard Medical School, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Sandholm, Niina" sort="Sandholm, Niina" uniqKey="Sandholm N" first="Niina" last="Sandholm">Niina Sandholm</name><affiliation><nlm:aff id="A172">Department of Biomedical Engineering and Computational Science, Aalto University School of Science, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A173">Department of Medicine, Division of Nephrology, Helsinki University Central Hospital, FI-00290 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A174">Folkhälsan Institute of Genetics, Folkhälsan Research Center, FI-00290 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Schadt, Eric E" sort="Schadt, Eric E" uniqKey="Schadt E" first="Eric E" last="Schadt">Eric E. Schadt</name><affiliation><nlm:aff id="A175">Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10580, USA</nlm:aff></affiliation></author><author><name sortKey="Scott, Robert A" sort="Scott, Robert A" uniqKey="Scott R" first="Robert A" last="Scott">Robert A. Scott</name><affiliation><nlm:aff id="A23">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Stolk, Lisette" sort="Stolk, Lisette" uniqKey="Stolk L" first="Lisette" last="Stolk">Lisette Stolk</name><affiliation><nlm:aff id="A38">Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Vallejo, Edgar E" sort="Vallejo, Edgar E" uniqKey="Vallejo E" first="Edgar E." last="Vallejo">Edgar E. Vallejo</name><affiliation><nlm:aff id="A176">Computer Science Department, Tecnológico de Monterrey, Atizapán de Zaragoza, 52926, Mexico</nlm:aff></affiliation></author><author><name sortKey="Westra, Harm Jan" sort="Westra, Harm Jan" uniqKey="Westra H" first="Harm-Jan" last="Westra">Harm-Jan Westra</name><affiliation><nlm:aff id="A32">Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Zondervan, Krina T" sort="Zondervan, Krina T" uniqKey="Zondervan K" first="Krina T" last="Zondervan">Krina T. Zondervan</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A177">Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation><nlm:aff id="A188">Institut Pasteur de Lille; INSERM, U744; Université de Lille 2; F-59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Arveiler, Dominique" sort="Arveiler, Dominique" uniqKey="Arveiler D" first="Dominique" last="Arveiler">Dominique Arveiler</name><affiliation><nlm:aff id="A189">Department of Epidemiology and Public Health, EA3430, University of Strasbourg, Faculty of Medicine, Strasbourg, France</nlm:aff></affiliation></author><author><name sortKey="Bakker, Stephan Jl" sort="Bakker, Stephan Jl" uniqKey="Bakker S" first="Stephan Jl" last="Bakker">Stephan Jl Bakker</name><affiliation><nlm:aff id="A190">Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Beilby, John" sort="Beilby, John" uniqKey="Beilby J" first="John" last="Beilby">John Beilby</name><affiliation><nlm:aff id="A71">PathWest Laboratory Medicine of Western Australia, NEDLANDS, Western Australia 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A191">Pathology and Laboratory Medicine, The University of Western Australia, Perth, Western Australia 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="Bergman, Richard N" sort="Bergman, Richard N" uniqKey="Bergman R" first="Richard N" last="Bergman">Richard N. Bergman</name><affiliation><nlm:aff id="A192">Cedars-Sinai Diabetes and Obesity Research Institute, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Blangero, John" sort="Blangero, John" uniqKey="Blangero J" first="John" last="Blangero">John Blangero</name><affiliation><nlm:aff id="A73">Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Brown, Morris J" sort="Brown, Morris J" uniqKey="Brown M" first="Morris J" last="Brown">Morris J. Brown</name><affiliation><nlm:aff id="A193">Clinical Pharmacology Unit, University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Burnier, Michel" sort="Burnier, Michel" uniqKey="Burnier M" first="Michel" last="Burnier">Michel Burnier</name><affiliation><nlm:aff id="A194">Service of Nephrology, Department of Medicine, Lausanne University Hospital (CHUV), Lausanne 1005, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="A195">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK</nlm:aff></affiliation></author><author><name sortKey="Chakravarti, Aravinda" sort="Chakravarti, Aravinda" uniqKey="Chakravarti A" first="Aravinda" last="Chakravarti">Aravinda Chakravarti</name><affiliation><nlm:aff id="A44">Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA</nlm:aff></affiliation></author><author><name sortKey="Chines, Peter S" sort="Chines, Peter S" uniqKey="Chines P" first="Peter S" last="Chines">Peter S. Chines</name><affiliation><nlm:aff id="A87">Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Claudi Boehm, Simone" sort="Claudi Boehm, Simone" uniqKey="Claudi Boehm S" first="Simone" last="Claudi-Boehm">Simone Claudi-Boehm</name><affiliation><nlm:aff id="A121">Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Collins, Francis S" sort="Collins, Francis S" uniqKey="Collins F" first="Francis S" last="Collins">Francis S. Collins</name><affiliation><nlm:aff id="A87">Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Crawford, Dana C" sort="Crawford, Dana C" uniqKey="Crawford D" first="Dana C" last="Crawford">Dana C. Crawford</name><affiliation><nlm:aff id="A196">Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville TN 37203, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A197">Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA</nlm:aff></affiliation></author><author><name sortKey="Danesh, John" sort="Danesh, John" uniqKey="Danesh J" first="John" last="Danesh">John Danesh</name><affiliation><nlm:aff id="A198">Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="De Faire, Ulf" sort="De Faire, Ulf" uniqKey="De Faire U" first="Ulf" last="De Faire">Ulf De Faire</name><affiliation><nlm:aff id="A92">Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="De Geus, Eco Jc" sort="De Geus, Eco Jc" uniqKey="De Geus E" first="Eco Jc" last="De Geus">Eco Jc De Geus</name><affiliation><nlm:aff id="A199">Biological Psychology, VU University Amsterdam, 1081BT Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A200">Institute for Research in Extramural Medicine, Institute for Health and Care Research, VU University, 1081BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Dorr, Marcus" sort="Dorr, Marcus" uniqKey="Dorr M" first="Marcus" last="Dörr">Marcus Dörr</name><affiliation><nlm:aff id="A201">Department of Internal Medicine B, University Medicine Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A202">DZHK (Deutsches Zentrum für Herz-Kreislaufforschung – German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Erbel, Raimund" sort="Erbel, Raimund" uniqKey="Erbel R" first="Raimund" last="Erbel">Raimund Erbel</name><affiliation><nlm:aff id="A203">Clinic of Cardiology, West-German Heart Centre, University Hospital Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A204">Department of General Practice and Primary Health Care, University of Helsinki, FI-00290 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A205">Unit of General Practice, Helsinki University Central Hospital, Helsinki 00290, Finland</nlm:aff></affiliation></author><author><name sortKey="Farrall, Martin" sort="Farrall, Martin" uniqKey="Farrall M" first="Martin" last="Farrall">Martin Farrall</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A47">Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK</nlm:aff></affiliation></author><author><name sortKey="Ferrannini, Ele" sort="Ferrannini, Ele" uniqKey="Ferrannini E" first="Ele" last="Ferrannini">Ele Ferrannini</name><affiliation><nlm:aff id="A206">Department of Internal Medicine, University of Pisa, Pisa, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A207">National Research Council Institute of Clinical Physiology, University of Pisa, Pisa, Italy</nlm:aff></affiliation></author><author><name sortKey="Ferrieres, Jean" sort="Ferrieres, Jean" uniqKey="Ferrieres J" first="Jean" last="Ferrières">Jean Ferrières</name><affiliation><nlm:aff id="A208">Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, France</nlm:aff></affiliation></author><author><name sortKey="Forouhi, Nita G" sort="Forouhi, Nita G" uniqKey="Forouhi N" first="Nita G" last="Forouhi">Nita G. Forouhi</name><affiliation><nlm:aff id="A23">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Forrester, Terrence" sort="Forrester, Terrence" uniqKey="Forrester T" first="Terrence" last="Forrester">Terrence Forrester</name><affiliation><nlm:aff id="A209">UWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica</nlm:aff></affiliation></author><author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H" last="Franco">Oscar H. Franco</name><affiliation><nlm:aff id="A54">Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Gansevoort, Ron T" sort="Gansevoort, Ron T" uniqKey="Gansevoort R" first="Ron T" last="Gansevoort">Ron T. Gansevoort</name><affiliation><nlm:aff id="A190">Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation><nlm:aff id="A69">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="A140">Icelandic Heart Association, Kopavogur 201, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A141">University of Iceland, Reykjavik 101, Iceland</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="A210">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="A90">Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Hattersley, Andrew T" sort="Hattersley, Andrew T" uniqKey="Hattersley A" first="Andrew T" last="Hattersley">Andrew T. Hattersley</name><affiliation><nlm:aff id="A211">Institute of Biomedical & Clinical Science, University of Exeter, Barrack Road, Exeter EX2 5DW, UK</nlm:aff></affiliation></author><author><name sortKey="Heliovaara, Markku" sort="Heliovaara, Markku" uniqKey="Heliovaara M" first="Markku" last="Heliövaara">Markku Heliövaara</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A" last="Hicks">Andrew A. Hicks</name><affiliation><nlm:aff id="A212">Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy - Affiliated Institute of the University of Lübeck, D-23562 Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Hingorani, Aroon D" sort="Hingorani, Aroon D" uniqKey="Hingorani A" first="Aroon D" last="Hingorani">Aroon D. Hingorani</name><affiliation><nlm:aff id="A213">Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK</nlm:aff></affiliation></author><author><name sortKey="Hoffmann, Wolfgang" sort="Hoffmann, Wolfgang" uniqKey="Hoffmann W" first="Wolfgang" last="Hoffmann">Wolfgang Hoffmann</name><affiliation><nlm:aff id="A111">Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A202">DZHK (Deutsches Zentrum für Herz-Kreislaufforschung – German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A54">Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name><affiliation><nlm:aff id="A62">Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Humphries, Steve E" sort="Humphries, Steve E" uniqKey="Humphries S" first="Steve E" last="Humphries">Steve E. Humphries</name><affiliation><nlm:aff id="A214">Centre for Cardiovascular Genetics, Institute Cardiovascular Sciences, University College London, London WC1E 6JJ, UK</nlm:aff></affiliation></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><affiliation><nlm:aff id="A215">Sansom Institute for Health Research, University of South Australia, Adelaide 5000, South Australia, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A216">School of Population Health, University of South Australia, Adelaide 5000, South Australia, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A217">South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A218">Population, Policy, and Practice, University College London Institute of Child Health, London WC1N 1EH, UK</nlm:aff></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation><nlm:aff id="A95">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A219">Hannover Unified Biobank, Hannover Medical School, Hannover, D-30625 Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation><nlm:aff id="A68">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A105">Biocenter Oulu, University of Oulu, FI-90014 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A220">National Institute for Health and Welfare, FI-90101 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A221">MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A222">Unit of Primary Care, Oulu University Hospital, FI-90220 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A223">Institute of Health Sciences, FI-90014 University of Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Johansen, Berit" sort="Johansen, Berit" uniqKey="Johansen B" first="Berit" last="Johansen">Berit Johansen</name><affiliation><nlm:aff id="A82">Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway</nlm:aff></affiliation></author><author><name sortKey="Jousilahti, Pekka" sort="Jousilahti, Pekka" uniqKey="Jousilahti P" first="Pekka" last="Jousilahti">Pekka Jousilahti</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Jula, Antti M" sort="Jula, Antti M" uniqKey="Jula A" first="Antti M" last="Jula">Antti M. Jula</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A86">Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A102">Hjelt Institute Department of Public Health, University of Helsinki, FI-00014 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kee, Frank" sort="Kee, Frank" uniqKey="Kee F" first="Frank" last="Kee">Frank Kee</name><affiliation><nlm:aff id="A224">UK Clinical Research Collaboration Centre of Excellence for Public Health (NI), Queens University of Belfast, Belfast, Northern Ireland</nlm:aff></affiliation></author><author><name sortKey="Keinanen Kiukaanniemi, Sirkka M" sort="Keinanen Kiukaanniemi, Sirkka M" uniqKey="Keinanen Kiukaanniemi S" first="Sirkka M" last="Keinanen-Kiukaanniemi">Sirkka M. Keinanen-Kiukaanniemi</name><affiliation><nlm:aff id="A225">Institute of Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A226">Unit of Primary Health Care/General Practice, Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S" last="Kooner">Jaspal S. Kooner</name><affiliation><nlm:aff id="A67">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A166">National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A227">Imperial College Healthcare NHS Trust, London W12 0HS, UK</nlm:aff></affiliation></author><author><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name><affiliation><nlm:aff id="A228">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA</nlm:aff></affiliation></author><author><name sortKey="Kovacs, Peter" sort="Kovacs, Peter" uniqKey="Kovacs P" first="Peter" last="Kovacs">Peter Kovacs</name><affiliation><nlm:aff id="A76">Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Kraja, Aldi T" sort="Kraja, Aldi T" uniqKey="Kraja A" first="Aldi T" last="Kraja">Aldi T. Kraja</name><affiliation><nlm:aff id="A46">Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name><affiliation><nlm:aff id="A229">Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A230">Department of Biological and Social Epidemiology, University of Essex, Wivenhoe Park, Colchester, Essex, CO4 3SQ, UK</nlm:aff></affiliation></author><author><name sortKey="Kuulasmaa, Kari" sort="Kuulasmaa, Kari" uniqKey="Kuulasmaa K" first="Kari" last="Kuulasmaa">Kari Kuulasmaa</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kuusisto, Johanna" sort="Kuusisto, Johanna" uniqKey="Kuusisto J" first="Johanna" last="Kuusisto">Johanna Kuusisto</name><affiliation><nlm:aff id="A231">Department of Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Lakka, Timo A" sort="Lakka, Timo A" uniqKey="Lakka T" first="Timo A" last="Lakka">Timo A. Lakka</name><affiliation><nlm:aff id="A100">Kuopio Research Institute of Exercise Medicine, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A232">Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A233">Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation><nlm:aff id="A23">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A229">Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="A234">Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI USA</nlm:aff></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:aff id="A235">Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine University of Tampere, FI-33520 Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Lyssenko, Valeriya" sort="Lyssenko, Valeriya" uniqKey="Lyssenko V" first="Valeriya" last="Lyssenko">Valeriya Lyssenko</name><affiliation><nlm:aff id="A236">Steno Diabetes Center A/S, Gentofte DK-2820, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A237">Lund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö 221 00, Sweden</nlm:aff></affiliation></author><author><name sortKey="M Nnisto, Satu" sort="M Nnisto, Satu" uniqKey="M Nnisto S" first="Satu" last="M Nnistö">Satu M Nnistö</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Marette, Andre" sort="Marette, Andre" uniqKey="Marette A" first="André" last="Marette">André Marette</name><affiliation><nlm:aff id="A238">Institut Universitaire de Cardiologie et de Pneumologie de Québec, Faculty of Medicine, Laval University, Quebec, QC G1V 0A6, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A239">Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada</nlm:aff></affiliation></author><author><name sortKey="Matise, Tara C" sort="Matise, Tara C" uniqKey="Matise T" first="Tara C" last="Matise">Tara C. Matise</name><affiliation><nlm:aff id="A42">Department of Genetics, Rutgers University, Piscataway, NJ USA</nlm:aff></affiliation></author><author><name sortKey="Mckenzie, Colin A" sort="Mckenzie, Colin A" uniqKey="Mckenzie C" first="Colin A" last="Mckenzie">Colin A. Mckenzie</name><affiliation><nlm:aff id="A209">UWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica</nlm:aff></affiliation></author><author><name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name><affiliation><nlm:aff id="A240">Department of Biostatistics, University of Washington, Seattle, WA 98195, USA</nlm:aff></affiliation></author><author><name sortKey="Musk, Arthur W" sort="Musk, Arthur W" uniqKey="Musk A" first="Arthur W" last="Musk">Arthur W. Musk</name><affiliation><nlm:aff id="A241">Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="Mohlenkamp, Stefan" sort="Mohlenkamp, Stefan" uniqKey="Mohlenkamp S" first="Stefan" last="Möhlenkamp">Stefan Möhlenkamp</name><affiliation><nlm:aff id="A203">Clinic of Cardiology, West-German Heart Centre, University Hospital Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Morris, Andrew D" sort="Morris, Andrew D" uniqKey="Morris A" first="Andrew D" last="Morris">Andrew D. Morris</name><affiliation><nlm:aff id="A85">Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK</nlm:aff></affiliation></author><author><name sortKey="Nelis, Mari" sort="Nelis, Mari" uniqKey="Nelis M" first="Mari" last="Nelis">Mari Nelis</name><affiliation><nlm:aff id="A9">Estonian Genome Center, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Ohlsson, Claes" sort="Ohlsson, Claes" uniqKey="Ohlsson C" first="Claes" last="Ohlsson">Claes Ohlsson</name><affiliation><nlm:aff id="A119">Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden</nlm:aff></affiliation></author><author><name sortKey="Oldehinkel, Albertine J" sort="Oldehinkel, Albertine J" uniqKey="Oldehinkel A" first="Albertine J" last="Oldehinkel">Albertine J. Oldehinkel</name><affiliation><nlm:aff id="A99">Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Ong, Ken K" sort="Ong, Ken K" uniqKey="Ong K" first="Ken K" last="Ong">Ken K. Ong</name><affiliation><nlm:aff id="A23">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A151">MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK</nlm:aff></affiliation></author><author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J" last="Palmer">Lyle J. Palmer</name><affiliation><nlm:aff id="A242">Epidemiology and Obstetrics & Gynaecology, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A243">Genetic Epidemiology & Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada</nlm:aff></affiliation></author><author><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W" last="Penninx">Brenda W. Penninx</name><affiliation><nlm:aff id="A200">Institute for Research in Extramural Medicine, Institute for Health and Care Research, VU University, 1081BT Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A244">Department of Psychiatry, Neuroscience Campus, VU University Amsterdam, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name><affiliation><nlm:aff id="A95">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A132">Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A145">Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P" last="Pramstaller">Peter P. Pramstaller</name><affiliation><nlm:aff id="A212">Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy - Affiliated Institute of the University of Lübeck, D-23562 Lübeck, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A245">Department of Neurology, General Central Hospital, Bolzano 39100, Italy</nlm:aff></affiliation></author><author><name sortKey="Raitakari, Olli T" sort="Raitakari, Olli T" uniqKey="Raitakari O" first="Olli T" last="Raitakari">Olli T. Raitakari</name><affiliation><nlm:aff id="A246">Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FI-20521 Turku, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A247">Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FI-20521 Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Rankinen, Tuomo" sort="Rankinen, Tuomo" uniqKey="Rankinen T" first="Tuomo" last="Rankinen">Tuomo Rankinen</name><affiliation><nlm:aff id="A248">Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA</nlm:aff></affiliation></author><author><name sortKey="Rao, Dc" sort="Rao, Dc" uniqKey="Rao D" first="Dc" last="Rao">Dc Rao</name><affiliation><nlm:aff id="A46">Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A60">Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A249">Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Rice, Treva K" sort="Rice, Treva K" uniqKey="Rice T" first="Treva K" last="Rice">Treva K. Rice</name><affiliation><nlm:aff id="A60">Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A249">Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name><affiliation><nlm:aff id="A136">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA 02215, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A250">Harvard Medical School, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Ritchie, Marylyn D" sort="Ritchie, Marylyn D" uniqKey="Ritchie M" first="Marylyn D." last="Ritchie">Marylyn D. Ritchie</name><affiliation><nlm:aff id="A251">Center for Systems Genomics, The Pennsylvania State University, University Park, PA 16802, USA</nlm:aff></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="A196">Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville TN 37203, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A252">Croatian Centre for Global Health, Faculty of Medicine, University of Split, 21000 Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J" last="Samani">Nilesh J. Samani</name><affiliation><nlm:aff id="A253">Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A254">National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, LE3 9QP, UK</nlm:aff></affiliation></author><author><name sortKey="Saramies, Jouko" sort="Saramies, Jouko" uniqKey="Saramies J" first="Jouko" last="Saramies">Jouko Saramies</name><affiliation><nlm:aff id="A255">South Carelia Central Hospital, 53130 Lappeenranta, Finland</nlm:aff></affiliation></author><author><name sortKey="Sarzynski, Mark A" sort="Sarzynski, Mark A" uniqKey="Sarzynski M" first="Mark A" last="Sarzynski">Mark A. Sarzynski</name><affiliation><nlm:aff id="A248">Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA</nlm:aff></affiliation></author><author><name sortKey="Schwarz, Peter Eh" sort="Schwarz, Peter Eh" uniqKey="Schwarz P" first="Peter Eh" last="Schwarz">Peter Eh Schwarz</name><affiliation><nlm:aff id="A97">Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A256">Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD), Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R" last="Shuldiner">Alan R. Shuldiner</name><affiliation><nlm:aff id="A257">Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A258">Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A259">Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center, Baltimore, MD 21201, USA</nlm:aff></affiliation></author><author><name sortKey="Staessen, Jan A" sort="Staessen, Jan A" uniqKey="Staessen J" first="Jan A" last="Staessen">Jan A. Staessen</name><affiliation><nlm:aff id="A260">Department of Epidemiology, Maastricht University, Maastricht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A261">Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, B-3000 Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Steinthorsdottir, Valgerdur" sort="Steinthorsdottir, Valgerdur" uniqKey="Steinthorsdottir V" first="Valgerdur" last="Steinthorsdottir">Valgerdur Steinthorsdottir</name><affiliation><nlm:aff id="A146">deCODE Genetics, Amgen inc., Reykjavik 101, Iceland</nlm:aff></affiliation></author><author><name sortKey="Stolk, Ronald P" sort="Stolk, Ronald P" uniqKey="Stolk R" first="Ronald P" last="Stolk">Ronald P. Stolk</name><affiliation><nlm:aff id="A107">Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Strauch, Konstantin" sort="Strauch, Konstantin" uniqKey="Strauch K" first="Konstantin" last="Strauch">Konstantin Strauch</name><affiliation><nlm:aff id="A69">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A131">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, D-81377 Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name><affiliation><nlm:aff id="A76">Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Tremblay, Angelo" sort="Tremblay, Angelo" uniqKey="Tremblay A" first="Angelo" last="Tremblay">Angelo Tremblay</name><affiliation><nlm:aff id="A262">Department of Kinesiology, Laval University, Quebec, QC G1V 0A6, Canada</nlm:aff></affiliation></author><author><name sortKey="Tremoli, Elena" sort="Tremoli, Elena" uniqKey="Tremoli E" first="Elena" last="Tremoli">Elena Tremoli</name><affiliation><nlm:aff id="A263">Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano & Centro Cardiologico Monzino, Instituto di Ricovero e Cura a Carattere Scientifico, Milan 20133, italy</nlm:aff></affiliation></author><author><name sortKey="Vohl, Marie Claude" sort="Vohl, Marie Claude" uniqKey="Vohl M" first="Marie-Claude" last="Vohl">Marie-Claude Vohl</name><affiliation><nlm:aff id="A239">Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A264">Department of Food Science and Nutrition, Laval University, Quebec, QC G1V 0A6, Canada</nlm:aff></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation><nlm:aff id="A62">Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A202">DZHK (Deutsches Zentrum für Herz-Kreislaufforschung – German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:aff id="A265">Department of Internal Medicine, University Hospital (CHUV) and University of Lausanne, 1011, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="A195">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK</nlm:aff></affiliation></author><author><name sortKey="Witteman, Jacqueline C" sort="Witteman, Jacqueline C" uniqKey="Witteman J" first="Jacqueline C" last="Witteman">Jacqueline C. Witteman</name><affiliation><nlm:aff id="A55">Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Adair, Linda S" sort="Adair, Linda S" uniqKey="Adair L" first="Linda S" last="Adair">Linda S. Adair</name><affiliation><nlm:aff id="A266">Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff></affiliation></author><author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name><affiliation><nlm:aff id="A267">Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A268">Ministry of Health, Victoria, Republic of Seychelles</nlm:aff></affiliation></author><author><name sortKey="Boehm, Bernhard O" sort="Boehm, Bernhard O" uniqKey="Boehm B" first="Bernhard O" last="Boehm">Bernhard O. Boehm</name><affiliation><nlm:aff id="A269">Lee Kong Chian School of Medicine, Imperial College London and Nanyang Technological University, Singapore, 637553 Singapore, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="A270">Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Bornstein, Stefan R" sort="Bornstein, Stefan R" uniqKey="Bornstein S" first="Stefan R" last="Bornstein">Stefan R. Bornstein</name><affiliation><nlm:aff id="A97">Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Bouchard, Claude" sort="Bouchard, Claude" uniqKey="Bouchard C" first="Claude" last="Bouchard">Claude Bouchard</name><affiliation><nlm:aff id="A248">Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA</nlm:aff></affiliation></author><author><name sortKey="Cauchi, Stephane" sort="Cauchi, Stephane" uniqKey="Cauchi S" first="Stéphane" last="Cauchi">Stéphane Cauchi</name><affiliation><nlm:aff id="A64">CNRS UMR 8199, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A65">European Genomic Institute for Diabetes, F-59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Université de Lille 2, F-59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Caulfield, Mark J" sort="Caulfield, Mark J" uniqKey="Caulfield M" first="Mark J" last="Caulfield">Mark J. Caulfield</name><affiliation><nlm:aff id="A271">Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK</nlm:aff></affiliation></author><author><name sortKey="Chambers, John C" sort="Chambers, John C" uniqKey="Chambers J" first="John C" last="Chambers">John C. Chambers</name><affiliation><nlm:aff id="A67">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A227">Imperial College Healthcare NHS Trust, London W12 0HS, UK</nlm:aff></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name><affiliation><nlm:aff id="A136">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA 02215, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A250">Harvard Medical School, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Cooper, Richard S" sort="Cooper, Richard S" uniqKey="Cooper R" first="Richard S" last="Cooper">Richard S. Cooper</name><affiliation><nlm:aff id="A144">Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, IL 61053, USA</nlm:aff></affiliation></author><author><name sortKey="Dedoussis, George" sort="Dedoussis, George" uniqKey="Dedoussis G" first="George" last="Dedoussis">George Dedoussis</name><affiliation><nlm:aff id="A114">Department of Dietetics-Nutrition, Harokopio University, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation><nlm:aff id="A61">Translational Gerontology Branch, National Institute on Aging, Baltimore MD 21225, USA</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="A58">Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A64">CNRS UMR 8199, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A65">European Genomic Institute for Diabetes, F-59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Université de Lille 2, F-59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Grabe, Hans Jorgen" sort="Grabe, Hans Jorgen" uniqKey="Grabe H" first="Hans-Jörgen" last="Grabe">Hans-Jörgen Grabe</name><affiliation><nlm:aff id="A272">Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS-Hospital Stralsund, D-17475 Greifswald, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A273">German Center for Neurodegenerative Diseases (DZNE), Rostock, Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name><affiliation><nlm:aff id="A10">Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hui, Jennie" sort="Hui, Jennie" uniqKey="Hui J" first="Jennie" last="Hui">Jennie Hui</name><affiliation><nlm:aff id="A71">PathWest Laboratory Medicine of Western Australia, NEDLANDS, Western Australia 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A191">Pathology and Laboratory Medicine, The University of Western Australia, Perth, Western Australia 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A274">School of Population Health, The University of Western Australia, Nedlands, Western Australia 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="Hveem, Kristian" sort="Hveem, Kristian" uniqKey="Hveem K" first="Kristian" last="Hveem">Kristian Hveem</name><affiliation><nlm:aff id="A108">Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim 7489, Norway</nlm:aff></affiliation></author><author><name sortKey="Jockel, Karl Heinz" sort="Jockel, Karl Heinz" uniqKey="Jockel K" first="Karl-Heinz" last="Jöckel">Karl-Heinz Jöckel</name><affiliation><nlm:aff id="A28">Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name><affiliation><nlm:aff id="A229">Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK</nlm:aff></affiliation></author><author><name sortKey="Kuh, Diana" sort="Kuh, Diana" uniqKey="Kuh D" first="Diana" last="Kuh">Diana Kuh</name><affiliation><nlm:aff id="A151">MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK</nlm:aff></affiliation></author><author><name sortKey="Laakso, Markku" sort="Laakso, Markku" uniqKey="Laakso M" first="Markku" last="Laakso">Markku Laakso</name><affiliation><nlm:aff id="A231">Department of Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation><nlm:aff id="A275">Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA</nlm:aff></affiliation></author><author><name sortKey="M Rz, Winfried" sort="M Rz, Winfried" uniqKey="M Rz W" first="Winfried" last="M Rz">Winfried M Rz</name><affiliation><nlm:aff id="A49">Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A137">Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria</nlm:aff></affiliation><affiliation><nlm:aff id="A276">Synlab Academy, Synlab Services GmbH, Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Munroe, Patricia B" sort="Munroe, Patricia B" uniqKey="Munroe P" first="Patricia B" last="Munroe">Patricia B. Munroe</name><affiliation><nlm:aff id="A271">Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK</nlm:aff></affiliation></author><author><name sortKey="Nj Lstad, Inger" sort="Nj Lstad, Inger" uniqKey="Nj Lstad I" first="Inger" last="Nj Lstad">Inger Nj Lstad</name><affiliation><nlm:aff id="A150">Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway</nlm:aff></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A" last="Oostra">Ben A. Oostra</name><affiliation><nlm:aff id="A36">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A110">Center for Medical Sytems Biology, Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A277">Department of Clinical Genetics, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Palmer, Colin Na" sort="Palmer, Colin Na" uniqKey="Palmer C" first="Colin Na" last="Palmer">Colin Na Palmer</name><affiliation><nlm:aff id="A85">Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK</nlm:aff></affiliation></author><author><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L" last="Pedersen">Nancy L. Pedersen</name><affiliation><nlm:aff id="A20">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name><affiliation><nlm:aff id="A9">Estonian Genome Center, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A86">Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Perusse, Louis" sort="Perusse, Louis" uniqKey="Perusse L" first="Louis" last="Pérusse">Louis Pérusse</name><affiliation><nlm:aff id="A239">Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A262">Department of Kinesiology, Laval University, Quebec, QC G1V 0A6, Canada</nlm:aff></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation><nlm:aff id="A228">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA</nlm:aff></affiliation></author><author><name sortKey="Power, Chris" sort="Power, Chris" uniqKey="Power C" first="Chris" last="Power">Chris Power</name><affiliation><nlm:aff id="A218">Population, Policy, and Practice, University College London Institute of Child Health, London WC1N 1EH, UK</nlm:aff></affiliation></author><author><name sortKey="Quertermous, Thomas" sort="Quertermous, Thomas" uniqKey="Quertermous T" first="Thomas" last="Quertermous">Thomas Quertermous</name><affiliation><nlm:aff id="A278">Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Rauramaa, Rainer" sort="Rauramaa, Rainer" uniqKey="Rauramaa R" first="Rainer" last="Rauramaa">Rainer Rauramaa</name><affiliation><nlm:aff id="A100">Kuopio Research Institute of Exercise Medicine, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A233">Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="A54">Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Saaristo, Timo E" sort="Saaristo, Timo E" uniqKey="Saaristo T" first="Timo E" last="Saaristo">Timo E. Saaristo</name><affiliation><nlm:aff id="A279">Finnish Diabetes Association, Kirjoniementie 15, FI-33680 Tampere, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A280">Pirkanmaa Hospital District, Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Saleheen, Danish" sort="Saleheen, Danish" uniqKey="Saleheen D" first="Danish" last="Saleheen">Danish Saleheen</name><affiliation><nlm:aff id="A199">Biological Psychology, VU University Amsterdam, 1081BT Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A281">Center for Non-Communicable Diseases, Karatchi, Pakistan</nlm:aff></affiliation><affiliation><nlm:aff id="A282">Department of Medicine, University of Pennsylvania, Philadelphia, USA</nlm:aff></affiliation></author><author><name sortKey="Sinisalo, Juha" sort="Sinisalo, Juha" uniqKey="Sinisalo J" first="Juha" last="Sinisalo">Juha Sinisalo</name><affiliation><nlm:aff id="A283">Helsinki University Central Hospital Heart and Lung Center, Department of Medicine, Helsinki University Central Hospital, FI-00290 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Slagboom, P Eline" sort="Slagboom, P Eline" uniqKey="Slagboom P" first="P Eline" last="Slagboom">P Eline Slagboom</name><affiliation><nlm:aff id="A38">Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation><nlm:aff id="A107">Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D" last="Spector">Tim D. Spector</name><affiliation><nlm:aff id="A52">Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><nlm:aff id="A146">deCODE Genetics, Amgen inc., Reykjavik 101, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A284">Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland</nlm:aff></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation><nlm:aff id="A76">Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Tuomilehto, Jaakko" sort="Tuomilehto, Jaakko" uniqKey="Tuomilehto J" first="Jaakko" last="Tuomilehto">Jaakko Tuomilehto</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A285">Instituto de Investigacion Sanitaria del Hospital Universario LaPaz (IdiPAZ), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A286">Diabetes Research Group, King Abdulaziz University, 21589 Jeddah, Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="A287">Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G" last="Uitterlinden">André G. Uitterlinden</name><affiliation><nlm:aff id="A54">Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Uusitupa, Matti" sort="Uusitupa, Matti" uniqKey="Uusitupa M" first="Matti" last="Uusitupa">Matti Uusitupa</name><affiliation><nlm:aff id="A288">Department of Public Health and Clinical Nutrition, University of Eastern Finland, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A289">Research Unit, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation><nlm:aff id="A32">Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A53">Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A290">Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, 3501 DG Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Veronesi, Giovanni" sort="Veronesi, Giovanni" uniqKey="Veronesi G" first="Giovanni" last="Veronesi">Giovanni Veronesi</name><affiliation><nlm:aff id="A291">EPIMED Research Center, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy</nlm:aff></affiliation></author><author><name sortKey="Walker, Mark" sort="Walker, Mark" uniqKey="Walker M" first="Mark" last="Walker">Mark Walker</name><affiliation><nlm:aff id="A292">Institute of Cellular Medicine, Newcastle University, Newcastle NE1 7RU, UK</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A23">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A47">Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK</nlm:aff></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H-Erich" last="Wichmann">H-Erich Wichmann</name><affiliation><nlm:aff id="A293">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, D-85764 Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A294">Klinikum Grosshadern, D-81377 Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A295">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Abecasis, Goncalo R" sort="Abecasis, Goncalo R" uniqKey="Abecasis G" first="Goncalo R" last="Abecasis">Goncalo R. Abecasis</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Assimes, Themistocles L" sort="Assimes, Themistocles L" uniqKey="Assimes T" first="Themistocles L" last="Assimes">Themistocles L. Assimes</name><affiliation><nlm:aff id="A278">Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation><nlm:aff id="A296">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Boehnke, Michael" sort="Boehnke, Michael" uniqKey="Boehnke M" first="Michael" last="Boehnke">Michael Boehnke</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Borecki, Ingrid B" sort="Borecki, Ingrid B" uniqKey="Borecki I" first="Ingrid B" last="Borecki">Ingrid B. Borecki</name><affiliation><nlm:aff id="A46">Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name><affiliation><nlm:aff id="A27">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A142">William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ UK</nlm:aff></affiliation><affiliation><nlm:aff id="A297">Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, 21589 Jeddah, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Franke, Lude" sort="Franke, Lude" uniqKey="Franke L" first="Lude" last="Franke">Lude Franke</name><affiliation><nlm:aff id="A32">Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Frayling, Timothy M" sort="Frayling, Timothy M" uniqKey="Frayling T" first="Timothy M" last="Frayling">Timothy M. Frayling</name><affiliation><nlm:aff id="A30">Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK</nlm:aff></affiliation></author><author><name sortKey="Groop, Leif C" sort="Groop, Leif C" uniqKey="Groop L" first="Leif C" last="Groop">Leif C. Groop</name><affiliation><nlm:aff id="A86">Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A237">Lund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö 221 00, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="A6">Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A159">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Kaplan, Robert C" sort="Kaplan, Robert C" uniqKey="Kaplan R" first="Robert C" last="Kaplan">Robert C. Kaplan</name><affiliation><nlm:aff id="A298">Albert Einstein College of Medicine. Department of Epidemiology and Population Health, Belfer 1306, NY 10461, USA</nlm:aff></affiliation></author><author><name sortKey="O Onnell, Jeffrey R" sort="O Onnell, Jeffrey R" uniqKey="O Onnell J" first="Jeffrey R" last="O Onnell">Jeffrey R. O Onnell</name><affiliation><nlm:aff id="A257">Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A258">Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA</nlm:aff></affiliation></author><author><name sortKey="Qi, Lu" sort="Qi, Lu" uniqKey="Qi L" first="Lu" last="Qi">Lu Qi</name><affiliation><nlm:aff id="A6">Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Schlessinger, David" sort="Schlessinger, David" uniqKey="Schlessinger D" first="David" last="Schlessinger">David Schlessinger</name><affiliation><nlm:aff id="A133">Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA</nlm:aff></affiliation></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P" last="Strachan">David P. Strachan</name><affiliation><nlm:aff id="A299">Division of Population Health Sciences & Education, St George’s, University of London, London SW17 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation><nlm:aff id="A146">deCODE Genetics, Amgen inc., Reykjavik 101, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A284">Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A36">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A110">Center for Medical Sytems Biology, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Willer, Cristen J" sort="Willer, Cristen J" uniqKey="Willer C" first="Cristen J" last="Willer">Cristen J. Willer</name><affiliation><nlm:aff id="A31">Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A300">Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA</nlm:aff></affiliation></author><author><name sortKey="Visscher, Peter M" sort="Visscher, Peter M" uniqKey="Visscher P" first="Peter M" last="Visscher">Peter M. Visscher</name><affiliation><nlm:aff id="A301">Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A302">The University of Queensland Diamantina Institute, The Translation Research Institute, Brisbane 4012, Australia</nlm:aff></affiliation></author><author><name sortKey="Yang, Jian" sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name><affiliation><nlm:aff id="A301">Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A302">The University of Queensland Diamantina Institute, The Translation Research Institute, Brisbane 4012, Australia</nlm:aff></affiliation></author><author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N" last="Hirschhorn">Joel N. Hirschhorn</name><affiliation><nlm:aff id="A11">Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Department of Genetics, Harvard Medical School, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Zillikens, M Carola" sort="Zillikens, M Carola" uniqKey="Zillikens M" first="M Carola" last="Zillikens">M Carola Zillikens</name><affiliation><nlm:aff id="A54">Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I" last="Mccarthy">Mark I. Mccarthy</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A303">Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Trust, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Speliotes, Elizabeth K" sort="Speliotes, Elizabeth K" uniqKey="Speliotes E" first="Elizabeth K" last="Speliotes">Elizabeth K. Speliotes</name><affiliation><nlm:aff id="A33">Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109</nlm:aff></affiliation></author><author><name sortKey="North, Kari E" sort="North, Kari E" uniqKey="North K" first="Kari E" last="North">Kari E. North</name><affiliation><nlm:aff id="A15">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A304">Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA</nlm:aff></affiliation></author><author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S" last="Fox">Caroline S. Fox</name><affiliation><nlm:aff id="A18">National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham MA 01702, USA</nlm:aff></affiliation></author><author><name sortKey="Barroso, Ines" sort="Barroso, Ines" uniqKey="Barroso I" first="Inês" last="Barroso">Inês Barroso</name><affiliation><nlm:aff id="A27">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A305">University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 OQQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A306">NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 OQQ, UK</nlm:aff></affiliation></author><author><name sortKey="Franks, Paul W" sort="Franks, Paul W" uniqKey="Franks P" first="Paul W" last="Franks">Paul W. Franks</name><affiliation><nlm:aff id="A1">Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå 901 87, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation></author><author><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M" last="Heid">Iris M. Heid</name><affiliation><nlm:aff id="A4">Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A69">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Loos, Ruth Jf" sort="Loos, Ruth Jf" uniqKey="Loos R" first="Ruth Jf" last="Loos">Ruth Jf Loos</name><affiliation><nlm:aff id="A23">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A307">The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A308">The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A309">The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff></affiliation></author><author><name sortKey="Cupples, L Adrienne" sort="Cupples, L Adrienne" uniqKey="Cupples L" first="L Adrienne" last="Cupples">L Adrienne Cupples</name><affiliation><nlm:aff id="A17">Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A18">National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham MA 01702, USA</nlm:aff></affiliation></author><author><name sortKey="Morris, Andrew P" sort="Morris, Andrew P" uniqKey="Morris A" first="Andrew P" last="Morris">Andrew P. Morris</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Estonian Genome Center, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A310">Department of Biostatistics, University of Liverpool, Liverpool L69 3GA, UK</nlm:aff></affiliation></author><author><name sortKey="Lindgren, Cecilia M" sort="Lindgren, Cecilia M" uniqKey="Lindgren C" first="Cecilia M" last="Lindgren">Cecilia M. Lindgren</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Mohlke, Karen L" sort="Mohlke, Karen L" uniqKey="Mohlke K" first="Karen L" last="Mohlke">Karen L. Mohlke</name><affiliation><nlm:aff id="A5">Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25673412</idno><idno type="pmc">4338562</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338562</idno><idno type="RBID">PMC:4338562</idno><idno type="doi">10.1038/nature14132</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002D69</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002D69</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">New genetic loci link adipose and insulin biology to body fat distribution</title><author><name sortKey="Shungin, Dmitry" sort="Shungin, Dmitry" uniqKey="Shungin D" first="Dmitry" last="Shungin">Dmitry Shungin</name><affiliation><nlm:aff id="A1">Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå 901 87, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Odontology, Umeå University, Umeå 901 85, Sweden</nlm:aff></affiliation></author><author><name sortKey="Winkler, Thomas W" sort="Winkler, Thomas W" uniqKey="Winkler T" first="Thomas W" last="Winkler">Thomas W. Winkler</name><affiliation><nlm:aff id="A4">Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Croteau Chonka, Damien C" sort="Croteau Chonka, Damien C" uniqKey="Croteau Chonka D" first="Damien C" last="Croteau-Chonka">Damien C. Croteau-Chonka</name><affiliation><nlm:aff id="A5">Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Ferreira, Teresa" sort="Ferreira, Teresa" uniqKey="Ferreira T" first="Teresa" last="Ferreira">Teresa Ferreira</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Locke, Adam E" sort="Locke, Adam E" uniqKey="Locke A" first="Adam E" last="Locke">Adam E. Locke</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA</nlm:aff></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Estonian Genome Center, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Strawbridge, Rona J" sort="Strawbridge, Rona J" uniqKey="Strawbridge R" first="Rona J" last="Strawbridge">Rona J. Strawbridge</name><affiliation><nlm:aff id="A10">Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden</nlm:aff></affiliation></author><author><name sortKey="Pers, Tune H" sort="Pers, Tune H" uniqKey="Pers T" first="Tune H" last="Pers">Tune H. Pers</name><affiliation><nlm:aff id="A11">Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Department of Genetics, Harvard Medical School, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby 2800, Denmark</nlm:aff></affiliation></author><author><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name><affiliation><nlm:aff id="A9">Estonian Genome Center, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Justice, Anne E" sort="Justice, Anne E" uniqKey="Justice A" first="Anne E" last="Justice">Anne E. Justice</name><affiliation><nlm:aff id="A15">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA</nlm:aff></affiliation></author><author><name sortKey="Workalemahu, Tsegaselassie" sort="Workalemahu, Tsegaselassie" uniqKey="Workalemahu T" first="Tsegaselassie" last="Workalemahu">Tsegaselassie Workalemahu</name><affiliation><nlm:aff id="A16">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Wu, Joseph M W" sort="Wu, Joseph M W" uniqKey="Wu J" first="Joseph M. W." last="Wu">Joseph M. W. Wu</name><affiliation><nlm:aff id="A17">Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Buchkovich, Martin L" sort="Buchkovich, Martin L" uniqKey="Buchkovich M" first="Martin L" last="Buchkovich">Martin L. Buchkovich</name><affiliation><nlm:aff id="A5">Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff></affiliation></author><author><name sortKey="Heard Costa, Nancy L" sort="Heard Costa, Nancy L" uniqKey="Heard Costa N" first="Nancy L" last="Heard-Costa">Nancy L. Heard-Costa</name><affiliation><nlm:aff id="A18">National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham MA 01702, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Roman, Tamara S" sort="Roman, Tamara S" uniqKey="Roman T" first="Tamara S" last="Roman">Tamara S. Roman</name><affiliation><nlm:aff id="A5">Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff></affiliation></author><author><name sortKey="Drong, Alexander W" sort="Drong, Alexander W" uniqKey="Drong A" first="Alexander W" last="Drong">Alexander W. Drong</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Song, Ci" sort="Song, Ci" uniqKey="Song C" first="Ci" last="Song">Ci Song</name><affiliation><nlm:aff id="A20">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation></author><author><name sortKey="Gustafsson, Stefan" sort="Gustafsson, Stefan" uniqKey="Gustafsson S" first="Stefan" last="Gustafsson">Stefan Gustafsson</name><affiliation><nlm:aff id="A21">Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation></author><author><name sortKey="Day, Felix R" sort="Day, Felix R" uniqKey="Day F" first="Felix R" last="Day">Felix R. Day</name><affiliation><nlm:aff id="A23">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Esko, Tonu" sort="Esko, Tonu" uniqKey="Esko T" first="Tonu" last="Esko">Tonu Esko</name><affiliation><nlm:aff id="A9">Estonian Genome Center, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Department of Genetics, Harvard Medical School, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Fall, Tove" sort="Fall, Tove" uniqKey="Fall T" first="Tove" last="Fall">Tove Fall</name><affiliation><nlm:aff id="A20">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name><affiliation><nlm:aff id="A24">Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne 1010, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A25">Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Department of Medical Genetics, University of Lausanne, Lausanne 1005, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Luan, Jian N" sort="Luan, Jian N" uniqKey="Luan J" first="Jian N" last="Luan">Jian N Luan</name><affiliation><nlm:aff id="A23">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Randall, Joshua C" sort="Randall, Joshua C" uniqKey="Randall J" first="Joshua C" last="Randall">Joshua C. Randall</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Scherag, Andre" sort="Scherag, Andre" uniqKey="Scherag A" first="André" last="Scherag">André Scherag</name><affiliation><nlm:aff id="A28">Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A29">Clinical Epidemiology, Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Vedantam, Sailaja" sort="Vedantam, Sailaja" uniqKey="Vedantam S" first="Sailaja" last="Vedantam">Sailaja Vedantam</name><affiliation><nlm:aff id="A11">Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Wood, Andrew R" sort="Wood, Andrew R" uniqKey="Wood A" first="Andrew R" last="Wood">Andrew R. Wood</name><affiliation><nlm:aff id="A30">Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK</nlm:aff></affiliation></author><author><name sortKey="Chen, Jin" sort="Chen, Jin" uniqKey="Chen J" first="Jin" last="Chen">Jin Chen</name><affiliation><nlm:aff id="A31">Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA</nlm:aff></affiliation></author><author><name sortKey="Fehrmann, Rudolf" sort="Fehrmann, Rudolf" uniqKey="Fehrmann R" first="Rudolf" last="Fehrmann">Rudolf Fehrmann</name><affiliation><nlm:aff id="A32">Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Karjalainen, Juha" sort="Karjalainen, Juha" uniqKey="Karjalainen J" first="Juha" last="Karjalainen">Juha Karjalainen</name><affiliation><nlm:aff id="A32">Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kahali, Bratati" sort="Kahali, Bratati" uniqKey="Kahali B" first="Bratati" last="Kahali">Bratati Kahali</name><affiliation><nlm:aff id="A33">Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109</nlm:aff></affiliation></author><author><name sortKey="Liu, Ching Ti" sort="Liu, Ching Ti" uniqKey="Liu C" first="Ching-Ti" last="Liu">Ching-Ti Liu</name><affiliation><nlm:aff id="A17">Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Ellen M" sort="Schmidt, Ellen M" uniqKey="Schmidt E" first="Ellen M" last="Schmidt">Ellen M. Schmidt</name><affiliation><nlm:aff id="A34">Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA</nlm:aff></affiliation></author><author><name sortKey="Absher, Devin" sort="Absher, Devin" uniqKey="Absher D" first="Devin" last="Absher">Devin Absher</name><affiliation><nlm:aff id="A35">HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA</nlm:aff></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation><nlm:aff id="A36">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Anderson, Denise" sort="Anderson, Denise" uniqKey="Anderson D" first="Denise" last="Anderson">Denise Anderson</name><affiliation><nlm:aff id="A37">Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Western Australia 6008, Australia</nlm:aff></affiliation></author><author><name sortKey="Beekman, Marian" sort="Beekman, Marian" uniqKey="Beekman M" first="Marian" last="Beekman">Marian Beekman</name><affiliation><nlm:aff id="A38">Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Bragg Gresham, Jennifer L" sort="Bragg Gresham, Jennifer L" uniqKey="Bragg Gresham J" first="Jennifer L" last="Bragg-Gresham">Jennifer L. Bragg-Gresham</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Kidney Epidemiology and Cost Center, University of Michigan, Ann Arbor, MI 48109</nlm:aff></affiliation></author><author><name sortKey="Buyske, Steven" sort="Buyske, Steven" uniqKey="Buyske S" first="Steven" last="Buyske">Steven Buyske</name><affiliation><nlm:aff id="A41">Department of Statistics & Biostatistics, Rutgers University, Piscataway, NJ USA</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Department of Genetics, Rutgers University, Piscataway, NJ USA</nlm:aff></affiliation></author><author><name sortKey="Demirkan, Ayse" sort="Demirkan, Ayse" uniqKey="Demirkan A" first="Ayse" last="Demirkan">Ayse Demirkan</name><affiliation><nlm:aff id="A36">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Department of Human Genetics, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Ehret, Georg B" sort="Ehret, Georg B" uniqKey="Ehret G" first="Georg B" last="Ehret">Georg B. Ehret</name><affiliation><nlm:aff id="A44">Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A45">Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva 1211, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Feitosa, Mary F" sort="Feitosa, Mary F" uniqKey="Feitosa M" first="Mary F" last="Feitosa">Mary F. Feitosa</name><affiliation><nlm:aff id="A46">Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A47">Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK</nlm:aff></affiliation></author><author><name sortKey="Jackson, Anne U" sort="Jackson, Anne U" uniqKey="Jackson A" first="Anne U" last="Jackson">Anne U. Jackson</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name><affiliation><nlm:aff id="A25">Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Department of Medical Genetics, University of Lausanne, Lausanne 1005, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A48">University Institute for Social and Preventative Medecine, Centre Hospitalier Universitaire Vaudois (CHUV), University of Lausanne, Lausanne 1005, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E" last="Kleber">Marcus E. Kleber</name><affiliation><nlm:aff id="A49">Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A50">Department of Internal Medicine II, Ulm University Medical Centre, D-89081 Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Kristiansson, Kati" sort="Kristiansson, Kati" uniqKey="Kristiansson K" first="Kati" last="Kristiansson">Kati Kristiansson</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation><nlm:aff id="A52">Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Leach, Irene Mateo" sort="Leach, Irene Mateo" uniqKey="Leach I" first="Irene Mateo" last="Leach">Irene Mateo Leach</name><affiliation><nlm:aff id="A53">Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Medina Gomez, Carolina" sort="Medina Gomez, Carolina" uniqKey="Medina Gomez C" first="Carolina" last="Medina-Gomez">Carolina Medina-Gomez</name><affiliation><nlm:aff id="A54">Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Palmer, Cameron D" sort="Palmer, Cameron D" uniqKey="Palmer C" first="Cameron D" last="Palmer">Cameron D. Palmer</name><affiliation><nlm:aff id="A11">Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Pasko, Dorota" sort="Pasko, Dorota" uniqKey="Pasko D" first="Dorota" last="Pasko">Dorota Pasko</name><affiliation><nlm:aff id="A30">Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK</nlm:aff></affiliation></author><author><name sortKey="Pechlivanis, Sonali" sort="Pechlivanis, Sonali" uniqKey="Pechlivanis S" first="Sonali" last="Pechlivanis">Sonali Pechlivanis</name><affiliation><nlm:aff id="A28">Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Peters, Marjolein J" sort="Peters, Marjolein J" uniqKey="Peters M" first="Marjolein J" last="Peters">Marjolein J. Peters</name><affiliation><nlm:aff id="A54">Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A58">Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Stan Kova, Alena" sort="Stan Kova, Alena" uniqKey="Stan Kova A" first="Alena" last="Stan Ková">Alena Stan Ková</name><affiliation><nlm:aff id="A59">University of Eastern Finland, FI-70210 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Sung, Yun Ju" sort="Sung, Yun Ju" uniqKey="Sung Y" first="Yun Ju" last="Sung">Yun Ju Sung</name><affiliation><nlm:aff id="A60">Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation><nlm:aff id="A61">Translational Gerontology Branch, National Institute on Aging, Baltimore MD 21225, USA</nlm:aff></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:aff id="A62">Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Van Vliet Ostaptchouk, Jana V" sort="Van Vliet Ostaptchouk, Jana V" uniqKey="Van Vliet Ostaptchouk J" first="Jana V" last="Van Vliet-Ostaptchouk">Jana V. Van Vliet-Ostaptchouk</name><affiliation><nlm:aff id="A63">Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Yengo, Loic" sort="Yengo, Loic" uniqKey="Yengo L" first="Loïc" last="Yengo">Loïc Yengo</name><affiliation><nlm:aff id="A64">CNRS UMR 8199, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A65">European Genomic Institute for Diabetes, F-59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Université de Lille 2, F-59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><affiliation><nlm:aff id="A67">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Albrecht, Eva" sort="Albrecht, Eva" uniqKey="Albrecht E" first="Eva" last="Albrecht">Eva Albrecht</name><affiliation><nlm:aff id="A69">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey=" Rnlov, Johan" sort=" Rnlov, Johan" uniqKey=" Rnlov J" first="Johan" last=" Rnlöv">Johan Rnlöv</name><affiliation><nlm:aff id="A21">Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A70">School of Health and Social Studies, Dalarna University, Falun, Sweden</nlm:aff></affiliation></author><author><name sortKey="Arscott, Gillian M" sort="Arscott, Gillian M" uniqKey="Arscott G" first="Gillian M" last="Arscott">Gillian M. Arscott</name><affiliation><nlm:aff id="A71">PathWest Laboratory Medicine of Western Australia, NEDLANDS, Western Australia 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name><affiliation><nlm:aff id="A72">Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Barrett, Amy" sort="Barrett, Amy" uniqKey="Barrett A" first="Amy" last="Barrett">Amy Barrett</name><affiliation><nlm:aff id="A57">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Bellis, Claire" sort="Bellis, Claire" uniqKey="Bellis C" first="Claire" last="Bellis">Claire Bellis</name><affiliation><nlm:aff id="A73">Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A74">Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Bennett, Amanda J" sort="Bennett, Amanda J" uniqKey="Bennett A" first="Amanda J" last="Bennett">Amanda J. Bennett</name><affiliation><nlm:aff id="A57">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Berne, Christian" sort="Berne, Christian" uniqKey="Berne C" first="Christian" last="Berne">Christian Berne</name><affiliation><nlm:aff id="A75">Department of Medical Sciences, Endocrinology, Diabetes and Metabolism, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation></author><author><name sortKey="Bluher, Matthias" sort="Bluher, Matthias" uniqKey="Bluher M" first="Matthias" last="Blüher">Matthias Blüher</name><affiliation><nlm:aff id="A76">Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Bohringer, Stefan" sort="Bohringer, Stefan" uniqKey="Bohringer S" first="Stefan" last="Böhringer">Stefan Böhringer</name><affiliation><nlm:aff id="A38">Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A78">Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Bonnet, Fabrice" sort="Bonnet, Fabrice" uniqKey="Bonnet F" first="Fabrice" last="Bonnet">Fabrice Bonnet</name><affiliation><nlm:aff id="A79">Inserm UMR991, Department of Endocrinology, University of Rennes, F-35000 Rennes, France</nlm:aff></affiliation></author><author><name sortKey="Bottcher, Yvonne" sort="Bottcher, Yvonne" uniqKey="Bottcher Y" first="Yvonne" last="Böttcher">Yvonne Böttcher</name><affiliation><nlm:aff id="A76">Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Bruinenberg, Marcel" sort="Bruinenberg, Marcel" uniqKey="Bruinenberg M" first="Marcel" last="Bruinenberg">Marcel Bruinenberg</name><affiliation><nlm:aff id="A80">LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Carba, Delia B" sort="Carba, Delia B" uniqKey="Carba D" first="Delia B" last="Carba">Delia B. Carba</name><affiliation><nlm:aff id="A81">USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines</nlm:aff></affiliation></author><author><name sortKey="Caspersen, Ida H" sort="Caspersen, Ida H" uniqKey="Caspersen I" first="Ida H" last="Caspersen">Ida H. Caspersen</name><affiliation><nlm:aff id="A82">Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway</nlm:aff></affiliation></author><author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name><affiliation><nlm:aff id="A83">Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK</nlm:aff></affiliation></author><author><name sortKey="Daw, E Warwick" sort="Daw, E Warwick" uniqKey="Daw E" first="E Warwick" last="Daw">E Warwick Daw</name><affiliation><nlm:aff id="A46">Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Deelen, Joris" sort="Deelen, Joris" uniqKey="Deelen J" first="Joris" last="Deelen">Joris Deelen</name><affiliation><nlm:aff id="A38">Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Deelman, Ewa" sort="Deelman, Ewa" uniqKey="Deelman E" first="Ewa" last="Deelman">Ewa Deelman</name><affiliation><nlm:aff id="A84">Information Sciences Institute, University of Southern California, Marina del Rey, California, USA</nlm:aff></affiliation></author><author><name sortKey="Delgado, Graciela" sort="Delgado, Graciela" uniqKey="Delgado G" first="Graciela" last="Delgado">Graciela Delgado</name><affiliation><nlm:aff id="A49">Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Doney, Alex Sf" sort="Doney, Alex Sf" uniqKey="Doney A" first="Alex Sf" last="Doney">Alex Sf Doney</name><affiliation><nlm:aff id="A85">Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK</nlm:aff></affiliation></author><author><name sortKey="Eklund, Niina" sort="Eklund, Niina" uniqKey="Eklund N" first="Niina" last="Eklund">Niina Eklund</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A86">Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Erdos, Michael R" sort="Erdos, Michael R" uniqKey="Erdos M" first="Michael R" last="Erdos">Michael R. Erdos</name><affiliation><nlm:aff id="A87">Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Estrada, Karol" sort="Estrada, Karol" uniqKey="Estrada K" first="Karol" last="Estrada">Karol Estrada</name><affiliation><nlm:aff id="A12">Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A88">Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Eury, Elodie" sort="Eury, Elodie" uniqKey="Eury E" first="Elodie" last="Eury">Elodie Eury</name><affiliation><nlm:aff id="A64">CNRS UMR 8199, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A65">European Genomic Institute for Diabetes, F-59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Université de Lille 2, F-59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Friedrich, Nele" sort="Friedrich, Nele" uniqKey="Friedrich N" first="Nele" last="Friedrich">Nele Friedrich</name><affiliation><nlm:aff id="A89">Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Garcia, Melissa E" sort="Garcia, Melissa E" uniqKey="Garcia M" first="Melissa E" last="Garcia">Melissa E. Garcia</name><affiliation><nlm:aff id="A90">Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Giedraitis, Vilmantas" sort="Giedraitis, Vilmantas" uniqKey="Giedraitis V" first="Vilmantas" last="Giedraitis">Vilmantas Giedraitis</name><affiliation><nlm:aff id="A91">Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation></author><author><name sortKey="Gigante, Bruna" sort="Gigante, Bruna" uniqKey="Gigante B" first="Bruna" last="Gigante">Bruna Gigante</name><affiliation><nlm:aff id="A92">Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Go, Alan S" sort="Go, Alan S" uniqKey="Go A" first="Alan S" last="Go">Alan S. Go</name><affiliation><nlm:aff id="A93">Kaiser Permanente, Division of Research, Oakland, CA 94612, USA</nlm:aff></affiliation></author><author><name sortKey="Golay, Alain" sort="Golay, Alain" uniqKey="Golay A" first="Alain" last="Golay">Alain Golay</name><affiliation><nlm:aff id="A94">Service of Therapeutic Education for Diabetes, Obesity and Chronic Diseases, Geneva University Hospital, Geneva CH-1211, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Grallert, Harald" sort="Grallert, Harald" uniqKey="Grallert H" first="Harald" last="Grallert">Harald Grallert</name><affiliation><nlm:aff id="A69">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A95">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A96">German Center for Diabetes Research (DZD), Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Grammer, Tanja B" sort="Grammer, Tanja B" uniqKey="Grammer T" first="Tanja B" last="Grammer">Tanja B. Grammer</name><affiliation><nlm:aff id="A49">Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Gr Ler, Jurgen" sort="Gr Ler, Jurgen" uniqKey="Gr Ler J" first="Jürgen" last="Gr Ler">Jürgen Gr Ler</name><affiliation><nlm:aff id="A97">Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Grewal, Jagvir" sort="Grewal, Jagvir" uniqKey="Grewal J" first="Jagvir" last="Grewal">Jagvir Grewal</name><affiliation><nlm:aff id="A67">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Groves, Christopher J" sort="Groves, Christopher J" uniqKey="Groves C" first="Christopher J" last="Groves">Christopher J. Groves</name><affiliation><nlm:aff id="A57">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Haller, Toomas" sort="Haller, Toomas" uniqKey="Haller T" first="Toomas" last="Haller">Toomas Haller</name><affiliation><nlm:aff id="A9">Estonian Genome Center, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Hallmans, Goran" sort="Hallmans, Goran" uniqKey="Hallmans G" first="Goran" last="Hallmans">Goran Hallmans</name><affiliation><nlm:aff id="A98">Department of Public Health and Clinical Medicine, Unit of Nutritional Research, Umeå University, Umeå 90187, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hartman, Catharina A" sort="Hartman, Catharina A" uniqKey="Hartman C" first="Catharina A" last="Hartman">Catharina A. Hartman</name><affiliation><nlm:aff id="A99">Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hassinen, Maija" sort="Hassinen, Maija" uniqKey="Hassinen M" first="Maija" last="Hassinen">Maija Hassinen</name><affiliation><nlm:aff id="A100">Kuopio Research Institute of Exercise Medicine, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="A101">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, Scotland, UK</nlm:aff></affiliation></author><author><name sortKey="Heikkil, Kauko" sort="Heikkil, Kauko" uniqKey="Heikkil K" first="Kauko" last="Heikkil">Kauko Heikkil</name><affiliation><nlm:aff id="A102">Hjelt Institute Department of Public Health, University of Helsinki, FI-00014 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Herzig, Karl Heinz" sort="Herzig, Karl Heinz" uniqKey="Herzig K" first="Karl-Heinz" last="Herzig">Karl-Heinz Herzig</name><affiliation><nlm:aff id="A103">Institute of Biomedicine, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A104">Medical Research Center Oulu and Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A105">Biocenter Oulu, University of Oulu, FI-90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Helmer, Quinta" sort="Helmer, Quinta" uniqKey="Helmer Q" first="Quinta" last="Helmer">Quinta Helmer</name><affiliation><nlm:aff id="A38">Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A78">Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A106">Faculty of Psychology and Education, VU University Amsterdam, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hillege, Hans L" sort="Hillege, Hans L" uniqKey="Hillege H" first="Hans L" last="Hillege">Hans L. Hillege</name><affiliation><nlm:aff id="A53">Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A107">Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Holmen, Oddgeir" sort="Holmen, Oddgeir" uniqKey="Holmen O" first="Oddgeir" last="Holmen">Oddgeir Holmen</name><affiliation><nlm:aff id="A108">Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim 7489, Norway</nlm:aff></affiliation></author><author><name sortKey="Hunt, Steven C" sort="Hunt, Steven C" uniqKey="Hunt S" first="Steven C" last="Hunt">Steven C. Hunt</name><affiliation><nlm:aff id="A109">Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84108, USA</nlm:aff></affiliation></author><author><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name><affiliation><nlm:aff id="A36">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A110">Center for Medical Sytems Biology, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Ittermann, Till" sort="Ittermann, Till" uniqKey="Ittermann T" first="Till" last="Ittermann">Till Ittermann</name><affiliation><nlm:aff id="A111">Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="James, Alan L" sort="James, Alan L" uniqKey="James A" first="Alan L" last="James">Alan L. James</name><affiliation><nlm:aff id="A112">Department of Pulmonary Physiology and Sleep Medicine, Nedlands, Western Australia 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A113">School of Medicine and Pharmacology, University of Western Australia, Crawley 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="Johansson, Ingegerd" sort="Johansson, Ingegerd" uniqKey="Johansson I" first="Ingegerd" last="Johansson">Ingegerd Johansson</name><affiliation><nlm:aff id="A3">Department of Odontology, Umeå University, Umeå 901 85, Sweden</nlm:aff></affiliation></author><author><name sortKey="Juliusdottir, Thorhildur" sort="Juliusdottir, Thorhildur" uniqKey="Juliusdottir T" first="Thorhildur" last="Juliusdottir">Thorhildur Juliusdottir</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Kalafati, Ioanna Panagiota" sort="Kalafati, Ioanna Panagiota" uniqKey="Kalafati I" first="Ioanna-Panagiota" last="Kalafati">Ioanna-Panagiota Kalafati</name><affiliation><nlm:aff id="A114">Department of Dietetics-Nutrition, Harokopio University, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Kinnunen, Leena" sort="Kinnunen, Leena" uniqKey="Kinnunen L" first="Leena" last="Kinnunen">Leena Kinnunen</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name><affiliation><nlm:aff id="A50">Department of Internal Medicine II, Ulm University Medical Centre, D-89081 Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Kooner, Ishminder K" sort="Kooner, Ishminder K" uniqKey="Kooner I" first="Ishminder K" last="Kooner">Ishminder K. Kooner</name><affiliation><nlm:aff id="A67">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff></affiliation></author><author><name sortKey="Kratzer, Wolfgang" sort="Kratzer, Wolfgang" uniqKey="Kratzer W" first="Wolfgang" last="Kratzer">Wolfgang Kratzer</name><affiliation><nlm:aff id="A115">Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Lamina, Claudia" sort="Lamina, Claudia" uniqKey="Lamina C" first="Claudia" last="Lamina">Claudia Lamina</name><affiliation><nlm:aff id="A116">Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria</nlm:aff></affiliation></author><author><name sortKey="Leander, Karin" sort="Leander, Karin" uniqKey="Leander K" first="Karin" last="Leander">Karin Leander</name><affiliation><nlm:aff id="A92">Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lee, Nanette R" sort="Lee, Nanette R" uniqKey="Lee N" first="Nanette R" last="Lee">Nanette R. Lee</name><affiliation><nlm:aff id="A81">USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines</nlm:aff></affiliation></author><author><name sortKey="Lichtner, Peter" sort="Lichtner, Peter" uniqKey="Lichtner P" first="Peter" last="Lichtner">Peter Lichtner</name><affiliation><nlm:aff id="A117">Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation><nlm:aff id="A118">Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Jaana" sort="Lindstrom, Jaana" uniqKey="Lindstrom J" first="Jaana" last="Lindström">Jaana Lindström</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Lobbens, Stephane" sort="Lobbens, Stephane" uniqKey="Lobbens S" first="Stéphane" last="Lobbens">Stéphane Lobbens</name><affiliation><nlm:aff id="A64">CNRS UMR 8199, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A65">European Genomic Institute for Diabetes, F-59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Université de Lille 2, F-59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Lorentzon, Mattias" sort="Lorentzon, Mattias" uniqKey="Lorentzon M" first="Mattias" last="Lorentzon">Mattias Lorentzon</name><affiliation><nlm:aff id="A119">Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden</nlm:aff></affiliation></author><author><name sortKey="Mach, Francois" sort="Mach, Francois" uniqKey="Mach F" first="François" last="Mach">François Mach</name><affiliation><nlm:aff id="A45">Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva 1211, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Magnusson, Patrik Ke" sort="Magnusson, Patrik Ke" uniqKey="Magnusson P" first="Patrik Ke" last="Magnusson">Patrik Ke Magnusson</name><affiliation><nlm:aff id="A20">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Mahajan, Anubha" sort="Mahajan, Anubha" uniqKey="Mahajan A" first="Anubha" last="Mahajan">Anubha Mahajan</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L" last="Mcardle">Wendy L. Mcardle</name><affiliation><nlm:aff id="A120">School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Menni, Cristina" sort="Menni, Cristina" uniqKey="Menni C" first="Cristina" last="Menni">Cristina Menni</name><affiliation><nlm:aff id="A52">Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Merger, Sigrun" sort="Merger, Sigrun" uniqKey="Merger S" first="Sigrun" last="Merger">Sigrun Merger</name><affiliation><nlm:aff id="A121">Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Mihailov, Evelin" sort="Mihailov, Evelin" uniqKey="Mihailov E" first="Evelin" last="Mihailov">Evelin Mihailov</name><affiliation><nlm:aff id="A9">Estonian Genome Center, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A122">Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Milani, Lili" sort="Milani, Lili" uniqKey="Milani L" first="Lili" last="Milani">Lili Milani</name><affiliation><nlm:aff id="A9">Estonian Genome Center, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Mills, Rebecca" sort="Mills, Rebecca" uniqKey="Mills R" first="Rebecca" last="Mills">Rebecca Mills</name><affiliation><nlm:aff id="A67">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff></affiliation></author><author><name sortKey="Moayyeri, Alireza" sort="Moayyeri, Alireza" uniqKey="Moayyeri A" first="Alireza" last="Moayyeri">Alireza Moayyeri</name><affiliation><nlm:aff id="A52">Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A123">Farr Institute of Health Informatics Research, University College London, London NW1 2DA, UK</nlm:aff></affiliation></author><author><name sortKey="Monda, Keri L" sort="Monda, Keri L" uniqKey="Monda K" first="Keri L" last="Monda">Keri L. Monda</name><affiliation><nlm:aff id="A15">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A124">The Center for Observational Research, Amgen, Inc., Thousand Oaks, CA 91320, USA</nlm:aff></affiliation></author><author><name sortKey="Mooijaart, Simon P" sort="Mooijaart, Simon P" uniqKey="Mooijaart S" first="Simon P" last="Mooijaart">Simon P. Mooijaart</name><affiliation><nlm:aff id="A38">Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A125">Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W" last="Mühleisen">Thomas W. Mühleisen</name><affiliation><nlm:aff id="A126">Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A127">Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Mulas, Antonella" sort="Mulas, Antonella" uniqKey="Mulas A" first="Antonella" last="Mulas">Antonella Mulas</name><affiliation><nlm:aff id="A128">Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Sardinia 09042, Italy</nlm:aff></affiliation></author><author><name sortKey="Muller, Gabriele" sort="Muller, Gabriele" uniqKey="Muller G" first="Gabriele" last="Müller">Gabriele Müller</name><affiliation><nlm:aff id="A129">Center for Evidence-based Healthcare, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name><affiliation><nlm:aff id="A69">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A130">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, D-81377 Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A131">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, D-81377 Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A132">Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Nagaraja, Ramaiah" sort="Nagaraja, Ramaiah" uniqKey="Nagaraja R" first="Ramaiah" last="Nagaraja">Ramaiah Nagaraja</name><affiliation><nlm:aff id="A133">Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA</nlm:aff></affiliation></author><author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A" last="Nalls">Michael A. Nalls</name><affiliation><nlm:aff id="A134">Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Narisu, Narisu" sort="Narisu, Narisu" uniqKey="Narisu N" first="Narisu" last="Narisu">Narisu Narisu</name><affiliation><nlm:aff id="A87">Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Glorioso, Nicola" sort="Glorioso, Nicola" uniqKey="Glorioso N" first="Nicola" last="Glorioso">Nicola Glorioso</name><affiliation><nlm:aff id="A135">Hypertension and Related Diseases Centre - AOU, University of Sassari Medical School, Sassari 07100, Italy</nlm:aff></affiliation></author><author><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M" last="Nolte">Ilja M. Nolte</name><affiliation><nlm:aff id="A107">Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Olden, Matthias" sort="Olden, Matthias" uniqKey="Olden M" first="Matthias" last="Olden">Matthias Olden</name><affiliation><nlm:aff id="A4">Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Rayner, Nigel W" sort="Rayner, Nigel W" uniqKey="Rayner N" first="Nigel W" last="Rayner">Nigel W. Rayner</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Renstrom, Frida" sort="Renstrom, Frida" uniqKey="Renstrom F" first="Frida" last="Renstrom">Frida Renstrom</name><affiliation><nlm:aff id="A2">Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden</nlm:aff></affiliation></author><author><name sortKey="Ried, Janina S" sort="Ried, Janina S" uniqKey="Ried J" first="Janina S" last="Ried">Janina S. Ried</name><affiliation><nlm:aff id="A69">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Robertson, Neil R" sort="Robertson, Neil R" uniqKey="Robertson N" first="Neil R" last="Robertson">Neil R. Robertson</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Rose, Lynda M" sort="Rose, Lynda M" uniqKey="Rose L" first="Lynda M" last="Rose">Lynda M. Rose</name><affiliation><nlm:aff id="A136">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA 02215, USA</nlm:aff></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation><nlm:aff id="A128">Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Sardinia 09042, Italy</nlm:aff></affiliation></author><author><name sortKey="Scharnagl, Hubert" sort="Scharnagl, Hubert" uniqKey="Scharnagl H" first="Hubert" last="Scharnagl">Hubert Scharnagl</name><affiliation><nlm:aff id="A137">Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria</nlm:aff></affiliation></author><author><name sortKey="Scholtens, Salome" sort="Scholtens, Salome" uniqKey="Scholtens S" first="Salome" last="Scholtens">Salome Scholtens</name><affiliation><nlm:aff id="A80">LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Sennblad, Bengt" sort="Sennblad, Bengt" uniqKey="Sennblad B" first="Bengt" last="Sennblad">Bengt Sennblad</name><affiliation><nlm:aff id="A10">Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A138">Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Seufferlein, Thomas" sort="Seufferlein, Thomas" uniqKey="Seufferlein T" first="Thomas" last="Seufferlein">Thomas Seufferlein</name><affiliation><nlm:aff id="A115">Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Sitlani, Colleen M" sort="Sitlani, Colleen M" uniqKey="Sitlani C" first="Colleen M" last="Sitlani">Colleen M. Sitlani</name><affiliation><nlm:aff id="A139">Department of Medicine, University of Washington, Seattle, WA 98101, USA</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name><affiliation><nlm:aff id="A140">Icelandic Heart Association, Kopavogur 201, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A141">University of Iceland, Reykjavik 101, Iceland</nlm:aff></affiliation></author><author><name sortKey="Stirrups, Kathleen" sort="Stirrups, Kathleen" uniqKey="Stirrups K" first="Kathleen" last="Stirrups">Kathleen Stirrups</name><affiliation><nlm:aff id="A27">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A142">William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ UK</nlm:aff></affiliation></author><author><name sortKey="Stringham, Heather M" sort="Stringham, Heather M" uniqKey="Stringham H" first="Heather M" last="Stringham">Heather M. Stringham</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Sundstrom, Johan" sort="Sundstrom, Johan" uniqKey="Sundstrom J" first="Johan" last="Sundström">Johan Sundström</name><affiliation><nlm:aff id="A118">Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation></author><author><name sortKey="Swertz, Morris A" sort="Swertz, Morris A" uniqKey="Swertz M" first="Morris A" last="Swertz">Morris A. Swertz</name><affiliation><nlm:aff id="A32">Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Swift, Amy J" sort="Swift, Amy J" uniqKey="Swift A" first="Amy J" last="Swift">Amy J. Swift</name><affiliation><nlm:aff id="A87">Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Syv Nen, Ann Christine" sort="Syv Nen, Ann Christine" uniqKey="Syv Nen A" first="Ann-Christine" last="Syv Nen">Ann-Christine Syv Nen</name><affiliation><nlm:aff id="A21">Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A143">Department of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala 75144, Sweden</nlm:aff></affiliation></author><author><name sortKey="Tayo, Bamidele O" sort="Tayo, Bamidele O" uniqKey="Tayo B" first="Bamidele O" last="Tayo">Bamidele O. Tayo</name><affiliation><nlm:aff id="A144">Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, IL 61053, USA</nlm:aff></affiliation></author><author><name sortKey="Thorand, Barbara" sort="Thorand, Barbara" uniqKey="Thorand B" first="Barbara" last="Thorand">Barbara Thorand</name><affiliation><nlm:aff id="A96">German Center for Diabetes Research (DZD), Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A145">Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation><nlm:aff id="A146">deCODE Genetics, Amgen inc., Reykjavik 101, Iceland</nlm:aff></affiliation></author><author><name sortKey="Tomaschitz, Andreas" sort="Tomaschitz, Andreas" uniqKey="Tomaschitz A" first="Andreas" last="Tomaschitz">Andreas Tomaschitz</name><affiliation><nlm:aff id="A147">Department of Cardiology, Medical University of Graz, Graz 8036, Austria</nlm:aff></affiliation></author><author><name sortKey="Troffa, Chiara" sort="Troffa, Chiara" uniqKey="Troffa C" first="Chiara" last="Troffa">Chiara Troffa</name><affiliation><nlm:aff id="A135">Hypertension and Related Diseases Centre - AOU, University of Sassari Medical School, Sassari 07100, Italy</nlm:aff></affiliation></author><author><name sortKey="Van Oort, Floor Va" sort="Van Oort, Floor Va" uniqKey="Van Oort F" first="Floor Va" last="Van Oort">Floor Va Van Oort</name><affiliation><nlm:aff id="A148">Department of Child and Adolescent Psychiatry, Psychology, Erasmus MC University Medical Centre, 3000 CB Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name><affiliation><nlm:aff id="A53">Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Vonk, Judith M" sort="Vonk, Judith M" uniqKey="Vonk J" first="Judith M" last="Vonk">Judith M. Vonk</name><affiliation><nlm:aff id="A107">Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Waite, Lindsay L" sort="Waite, Lindsay L" uniqKey="Waite L" first="Lindsay L" last="Waite">Lindsay L. Waite</name><affiliation><nlm:aff id="A35">HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA</nlm:aff></affiliation></author><author><name sortKey="Wennauer, Roman" sort="Wennauer, Roman" uniqKey="Wennauer R" first="Roman" last="Wennauer">Roman Wennauer</name><affiliation><nlm:aff id="A149">Department of Clinical Chemistry, Ulm University Medical Centre, D-89081 Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Wilsgaard, Tom" sort="Wilsgaard, Tom" uniqKey="Wilsgaard T" first="Tom" last="Wilsgaard">Tom Wilsgaard</name><affiliation><nlm:aff id="A150">Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway</nlm:aff></affiliation></author><author><name sortKey="Wojczynski, Mary K" sort="Wojczynski, Mary K" uniqKey="Wojczynski M" first="Mary K" last="Wojczynski">Mary K. Wojczynski</name><affiliation><nlm:aff id="A46">Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Wong, Andrew" sort="Wong, Andrew" uniqKey="Wong A" first="Andrew" last="Wong">Andrew Wong</name><affiliation><nlm:aff id="A151">MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK</nlm:aff></affiliation></author><author><name sortKey="Zhang, Qunyuan" sort="Zhang, Qunyuan" uniqKey="Zhang Q" first="Qunyuan" last="Zhang">Qunyuan Zhang</name><affiliation><nlm:aff id="A46">Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="A23">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Brennan, Eoin P" sort="Brennan, Eoin P" uniqKey="Brennan E" first="Eoin P." last="Brennan">Eoin P. Brennan</name><affiliation><nlm:aff id="A152">Diabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland</nlm:aff></affiliation></author><author><name sortKey="Choi, Murim" sort="Choi, Murim" uniqKey="Choi M" first="Murim" last="Choi">Murim Choi</name><affiliation><nlm:aff id="A153">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Per" sort="Eriksson, Per" uniqKey="Eriksson P" first="Per" last="Eriksson">Per Eriksson</name><affiliation><nlm:aff id="A10">Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden</nlm:aff></affiliation></author><author><name sortKey="Folkersen, Lasse" sort="Folkersen, Lasse" uniqKey="Folkersen L" first="Lasse" last="Folkersen">Lasse Folkersen</name><affiliation><nlm:aff id="A10">Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden</nlm:aff></affiliation></author><author><name sortKey="Franco Cereceda, Anders" sort="Franco Cereceda, Anders" uniqKey="Franco Cereceda A" first="Anders" last="Franco-Cereceda">Anders Franco-Cereceda</name><affiliation><nlm:aff id="A154">Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17176, Sweden</nlm:aff></affiliation></author><author><name sortKey="Gharavi, Ali G" sort="Gharavi, Ali G" uniqKey="Gharavi A" first="Ali G" last="Gharavi">Ali G. Gharavi</name><affiliation><nlm:aff id="A155">Department of Medicine, Columbia University College of Physicians and Surgeons, New York NY, USA</nlm:aff></affiliation></author><author><name sortKey="Hedman, Sa K" sort="Hedman, Sa K" uniqKey="Hedman " first=" Sa K" last="Hedman"> Sa K. Hedman</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hivert, Marie France" sort="Hivert, Marie France" uniqKey="Hivert M" first="Marie-France" last="Hivert">Marie-France Hivert</name><affiliation><nlm:aff id="A156">Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, MA</nlm:aff></affiliation><affiliation><nlm:aff id="A157">Massachusetts General Hospital, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Huang, Jinyan" sort="Huang, Jinyan" uniqKey="Huang J" first="Jinyan" last="Huang">Jinyan Huang</name><affiliation><nlm:aff id="A158">State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China</nlm:aff></affiliation><affiliation><nlm:aff id="A159">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Kanoni, Stavroula" sort="Kanoni, Stavroula" uniqKey="Kanoni S" first="Stavroula" last="Kanoni">Stavroula Kanoni</name><affiliation><nlm:aff id="A142">William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ UK</nlm:aff></affiliation></author><author><name sortKey="Karpe, Fredrik" sort="Karpe, Fredrik" uniqKey="Karpe F" first="Fredrik" last="Karpe">Fredrik Karpe</name><affiliation><nlm:aff id="A57">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A160">NIHR Oxford Biomedical Research Centre, OUH Trust, Oxford OX3 7LE, UK</nlm:aff></affiliation></author><author><name sortKey="Keildson, Sarah" sort="Keildson, Sarah" uniqKey="Keildson S" first="Sarah" last="Keildson">Sarah Keildson</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Kiryluk, Krzysztof" sort="Kiryluk, Krzysztof" uniqKey="Kiryluk K" first="Krzysztof" last="Kiryluk">Krzysztof Kiryluk</name><affiliation><nlm:aff id="A155">Department of Medicine, Columbia University College of Physicians and Surgeons, New York NY, USA</nlm:aff></affiliation></author><author><name sortKey="Liang, Liming" sort="Liang, Liming" uniqKey="Liang L" first="Liming" last="Liang">Liming Liang</name><affiliation><nlm:aff id="A159">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A161">Harvard School of Public Health, Department of Biostatistics, Harvard University, Boston, MA 2115, USA</nlm:aff></affiliation></author><author><name sortKey="Lifton, Richard P" sort="Lifton, Richard P" uniqKey="Lifton R" first="Richard P" last="Lifton">Richard P. Lifton</name><affiliation><nlm:aff id="A162">Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, New Haven CT, USA</nlm:aff></affiliation></author><author><name sortKey="Ma, Baoshan" sort="Ma, Baoshan" uniqKey="Ma B" first="Baoshan" last="Ma">Baoshan Ma</name><affiliation><nlm:aff id="A159">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A163">College of Information Science and Technology, Dalian Maritime University, Dalian, Liaoning 116026, China</nlm:aff></affiliation></author><author><name sortKey="Mcknight, Amy J" sort="Mcknight, Amy J" uniqKey="Mcknight A" first="Amy J" last="Mcknight">Amy J. Mcknight</name><affiliation><nlm:aff id="A164">Nephrology Research, Centre for Public Health, Queen’s University of Belfast, Belfast, Co. Down BT9 7AB, UK</nlm:aff></affiliation></author><author><name sortKey="Mcpherson, Ruth" sort="Mcpherson, Ruth" uniqKey="Mcpherson R" first="Ruth" last="Mcpherson">Ruth Mcpherson</name><affiliation><nlm:aff id="A165">University of Ottawa Heart Institute, Ottawa K1Y 4W7, Canada</nlm:aff></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation><nlm:aff id="A9">Estonian Genome Center, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A122">Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Min, Josine L" sort="Min, Josine L" uniqKey="Min J" first="Josine L" last="Min">Josine L. Min</name><affiliation><nlm:aff id="A120">School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Moffatt, Miriam F" sort="Moffatt, Miriam F" uniqKey="Moffatt M" first="Miriam F" last="Moffatt">Miriam F. Moffatt</name><affiliation><nlm:aff id="A166">National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK</nlm:aff></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W" last="Montgomery">Grant W. Montgomery</name><affiliation><nlm:aff id="A167">QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Murabito, Joanne M" sort="Murabito, Joanne M" uniqKey="Murabito J" first="Joanne M" last="Murabito">Joanne M. Murabito</name><affiliation><nlm:aff id="A18">National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham MA 01702, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A168">Section of General Internal Medicine, Boston University School of Medicine, Boston, MA 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Nicholson, George" sort="Nicholson, George" uniqKey="Nicholson G" first="George" last="Nicholson">George Nicholson</name><affiliation><nlm:aff id="A169">Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A170">MRC Harwell, Harwell Science and Innovation Campus, Harwell, UK</nlm:aff></affiliation></author><author><name sortKey="Nyholt, Dale R" sort="Nyholt, Dale R" uniqKey="Nyholt D" first="Dale R" last="Nyholt">Dale R. Nyholt</name><affiliation><nlm:aff id="A167">QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A171">Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia</nlm:aff></affiliation></author><author><name sortKey="Olsson, Christian" sort="Olsson, Christian" uniqKey="Olsson C" first="Christian" last="Olsson">Christian Olsson</name><affiliation><nlm:aff id="A154">Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17176, Sweden</nlm:aff></affiliation></author><author><name sortKey="Perry, John Rb" sort="Perry, John Rb" uniqKey="Perry J" first="John Rb" last="Perry">John Rb Perry</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Reinmaa, Eva" sort="Reinmaa, Eva" uniqKey="Reinmaa E" first="Eva" last="Reinmaa">Eva Reinmaa</name><affiliation><nlm:aff id="A9">Estonian Genome Center, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Salem, Rany M" sort="Salem, Rany M" uniqKey="Salem R" first="Rany M" last="Salem">Rany M. Salem</name><affiliation><nlm:aff id="A11">Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Department of Genetics, Harvard Medical School, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Sandholm, Niina" sort="Sandholm, Niina" uniqKey="Sandholm N" first="Niina" last="Sandholm">Niina Sandholm</name><affiliation><nlm:aff id="A172">Department of Biomedical Engineering and Computational Science, Aalto University School of Science, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A173">Department of Medicine, Division of Nephrology, Helsinki University Central Hospital, FI-00290 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A174">Folkhälsan Institute of Genetics, Folkhälsan Research Center, FI-00290 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Schadt, Eric E" sort="Schadt, Eric E" uniqKey="Schadt E" first="Eric E" last="Schadt">Eric E. Schadt</name><affiliation><nlm:aff id="A175">Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10580, USA</nlm:aff></affiliation></author><author><name sortKey="Scott, Robert A" sort="Scott, Robert A" uniqKey="Scott R" first="Robert A" last="Scott">Robert A. Scott</name><affiliation><nlm:aff id="A23">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Stolk, Lisette" sort="Stolk, Lisette" uniqKey="Stolk L" first="Lisette" last="Stolk">Lisette Stolk</name><affiliation><nlm:aff id="A38">Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Vallejo, Edgar E" sort="Vallejo, Edgar E" uniqKey="Vallejo E" first="Edgar E." last="Vallejo">Edgar E. Vallejo</name><affiliation><nlm:aff id="A176">Computer Science Department, Tecnológico de Monterrey, Atizapán de Zaragoza, 52926, Mexico</nlm:aff></affiliation></author><author><name sortKey="Westra, Harm Jan" sort="Westra, Harm Jan" uniqKey="Westra H" first="Harm-Jan" last="Westra">Harm-Jan Westra</name><affiliation><nlm:aff id="A32">Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Zondervan, Krina T" sort="Zondervan, Krina T" uniqKey="Zondervan K" first="Krina T" last="Zondervan">Krina T. Zondervan</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A177">Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation><nlm:aff id="A188">Institut Pasteur de Lille; INSERM, U744; Université de Lille 2; F-59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Arveiler, Dominique" sort="Arveiler, Dominique" uniqKey="Arveiler D" first="Dominique" last="Arveiler">Dominique Arveiler</name><affiliation><nlm:aff id="A189">Department of Epidemiology and Public Health, EA3430, University of Strasbourg, Faculty of Medicine, Strasbourg, France</nlm:aff></affiliation></author><author><name sortKey="Bakker, Stephan Jl" sort="Bakker, Stephan Jl" uniqKey="Bakker S" first="Stephan Jl" last="Bakker">Stephan Jl Bakker</name><affiliation><nlm:aff id="A190">Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Beilby, John" sort="Beilby, John" uniqKey="Beilby J" first="John" last="Beilby">John Beilby</name><affiliation><nlm:aff id="A71">PathWest Laboratory Medicine of Western Australia, NEDLANDS, Western Australia 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A191">Pathology and Laboratory Medicine, The University of Western Australia, Perth, Western Australia 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="Bergman, Richard N" sort="Bergman, Richard N" uniqKey="Bergman R" first="Richard N" last="Bergman">Richard N. Bergman</name><affiliation><nlm:aff id="A192">Cedars-Sinai Diabetes and Obesity Research Institute, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Blangero, John" sort="Blangero, John" uniqKey="Blangero J" first="John" last="Blangero">John Blangero</name><affiliation><nlm:aff id="A73">Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Brown, Morris J" sort="Brown, Morris J" uniqKey="Brown M" first="Morris J" last="Brown">Morris J. Brown</name><affiliation><nlm:aff id="A193">Clinical Pharmacology Unit, University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Burnier, Michel" sort="Burnier, Michel" uniqKey="Burnier M" first="Michel" last="Burnier">Michel Burnier</name><affiliation><nlm:aff id="A194">Service of Nephrology, Department of Medicine, Lausanne University Hospital (CHUV), Lausanne 1005, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="A195">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK</nlm:aff></affiliation></author><author><name sortKey="Chakravarti, Aravinda" sort="Chakravarti, Aravinda" uniqKey="Chakravarti A" first="Aravinda" last="Chakravarti">Aravinda Chakravarti</name><affiliation><nlm:aff id="A44">Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA</nlm:aff></affiliation></author><author><name sortKey="Chines, Peter S" sort="Chines, Peter S" uniqKey="Chines P" first="Peter S" last="Chines">Peter S. Chines</name><affiliation><nlm:aff id="A87">Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Claudi Boehm, Simone" sort="Claudi Boehm, Simone" uniqKey="Claudi Boehm S" first="Simone" last="Claudi-Boehm">Simone Claudi-Boehm</name><affiliation><nlm:aff id="A121">Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Collins, Francis S" sort="Collins, Francis S" uniqKey="Collins F" first="Francis S" last="Collins">Francis S. Collins</name><affiliation><nlm:aff id="A87">Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Crawford, Dana C" sort="Crawford, Dana C" uniqKey="Crawford D" first="Dana C" last="Crawford">Dana C. Crawford</name><affiliation><nlm:aff id="A196">Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville TN 37203, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A197">Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA</nlm:aff></affiliation></author><author><name sortKey="Danesh, John" sort="Danesh, John" uniqKey="Danesh J" first="John" last="Danesh">John Danesh</name><affiliation><nlm:aff id="A198">Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="De Faire, Ulf" sort="De Faire, Ulf" uniqKey="De Faire U" first="Ulf" last="De Faire">Ulf De Faire</name><affiliation><nlm:aff id="A92">Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="De Geus, Eco Jc" sort="De Geus, Eco Jc" uniqKey="De Geus E" first="Eco Jc" last="De Geus">Eco Jc De Geus</name><affiliation><nlm:aff id="A199">Biological Psychology, VU University Amsterdam, 1081BT Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A200">Institute for Research in Extramural Medicine, Institute for Health and Care Research, VU University, 1081BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Dorr, Marcus" sort="Dorr, Marcus" uniqKey="Dorr M" first="Marcus" last="Dörr">Marcus Dörr</name><affiliation><nlm:aff id="A201">Department of Internal Medicine B, University Medicine Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A202">DZHK (Deutsches Zentrum für Herz-Kreislaufforschung – German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Erbel, Raimund" sort="Erbel, Raimund" uniqKey="Erbel R" first="Raimund" last="Erbel">Raimund Erbel</name><affiliation><nlm:aff id="A203">Clinic of Cardiology, West-German Heart Centre, University Hospital Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A204">Department of General Practice and Primary Health Care, University of Helsinki, FI-00290 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A205">Unit of General Practice, Helsinki University Central Hospital, Helsinki 00290, Finland</nlm:aff></affiliation></author><author><name sortKey="Farrall, Martin" sort="Farrall, Martin" uniqKey="Farrall M" first="Martin" last="Farrall">Martin Farrall</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A47">Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK</nlm:aff></affiliation></author><author><name sortKey="Ferrannini, Ele" sort="Ferrannini, Ele" uniqKey="Ferrannini E" first="Ele" last="Ferrannini">Ele Ferrannini</name><affiliation><nlm:aff id="A206">Department of Internal Medicine, University of Pisa, Pisa, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A207">National Research Council Institute of Clinical Physiology, University of Pisa, Pisa, Italy</nlm:aff></affiliation></author><author><name sortKey="Ferrieres, Jean" sort="Ferrieres, Jean" uniqKey="Ferrieres J" first="Jean" last="Ferrières">Jean Ferrières</name><affiliation><nlm:aff id="A208">Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, France</nlm:aff></affiliation></author><author><name sortKey="Forouhi, Nita G" sort="Forouhi, Nita G" uniqKey="Forouhi N" first="Nita G" last="Forouhi">Nita G. Forouhi</name><affiliation><nlm:aff id="A23">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Forrester, Terrence" sort="Forrester, Terrence" uniqKey="Forrester T" first="Terrence" last="Forrester">Terrence Forrester</name><affiliation><nlm:aff id="A209">UWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica</nlm:aff></affiliation></author><author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H" last="Franco">Oscar H. Franco</name><affiliation><nlm:aff id="A54">Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Gansevoort, Ron T" sort="Gansevoort, Ron T" uniqKey="Gansevoort R" first="Ron T" last="Gansevoort">Ron T. Gansevoort</name><affiliation><nlm:aff id="A190">Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation><nlm:aff id="A69">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="A140">Icelandic Heart Association, Kopavogur 201, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A141">University of Iceland, Reykjavik 101, Iceland</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="A210">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="A90">Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Hattersley, Andrew T" sort="Hattersley, Andrew T" uniqKey="Hattersley A" first="Andrew T" last="Hattersley">Andrew T. Hattersley</name><affiliation><nlm:aff id="A211">Institute of Biomedical & Clinical Science, University of Exeter, Barrack Road, Exeter EX2 5DW, UK</nlm:aff></affiliation></author><author><name sortKey="Heliovaara, Markku" sort="Heliovaara, Markku" uniqKey="Heliovaara M" first="Markku" last="Heliövaara">Markku Heliövaara</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A" last="Hicks">Andrew A. Hicks</name><affiliation><nlm:aff id="A212">Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy - Affiliated Institute of the University of Lübeck, D-23562 Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Hingorani, Aroon D" sort="Hingorani, Aroon D" uniqKey="Hingorani A" first="Aroon D" last="Hingorani">Aroon D. Hingorani</name><affiliation><nlm:aff id="A213">Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK</nlm:aff></affiliation></author><author><name sortKey="Hoffmann, Wolfgang" sort="Hoffmann, Wolfgang" uniqKey="Hoffmann W" first="Wolfgang" last="Hoffmann">Wolfgang Hoffmann</name><affiliation><nlm:aff id="A111">Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A202">DZHK (Deutsches Zentrum für Herz-Kreislaufforschung – German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A54">Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name><affiliation><nlm:aff id="A62">Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Humphries, Steve E" sort="Humphries, Steve E" uniqKey="Humphries S" first="Steve E" last="Humphries">Steve E. Humphries</name><affiliation><nlm:aff id="A214">Centre for Cardiovascular Genetics, Institute Cardiovascular Sciences, University College London, London WC1E 6JJ, UK</nlm:aff></affiliation></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><affiliation><nlm:aff id="A215">Sansom Institute for Health Research, University of South Australia, Adelaide 5000, South Australia, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A216">School of Population Health, University of South Australia, Adelaide 5000, South Australia, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A217">South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A218">Population, Policy, and Practice, University College London Institute of Child Health, London WC1N 1EH, UK</nlm:aff></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation><nlm:aff id="A95">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A219">Hannover Unified Biobank, Hannover Medical School, Hannover, D-30625 Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation><nlm:aff id="A68">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A105">Biocenter Oulu, University of Oulu, FI-90014 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A220">National Institute for Health and Welfare, FI-90101 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A221">MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A222">Unit of Primary Care, Oulu University Hospital, FI-90220 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A223">Institute of Health Sciences, FI-90014 University of Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Johansen, Berit" sort="Johansen, Berit" uniqKey="Johansen B" first="Berit" last="Johansen">Berit Johansen</name><affiliation><nlm:aff id="A82">Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway</nlm:aff></affiliation></author><author><name sortKey="Jousilahti, Pekka" sort="Jousilahti, Pekka" uniqKey="Jousilahti P" first="Pekka" last="Jousilahti">Pekka Jousilahti</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Jula, Antti M" sort="Jula, Antti M" uniqKey="Jula A" first="Antti M" last="Jula">Antti M. Jula</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A86">Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A102">Hjelt Institute Department of Public Health, University of Helsinki, FI-00014 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kee, Frank" sort="Kee, Frank" uniqKey="Kee F" first="Frank" last="Kee">Frank Kee</name><affiliation><nlm:aff id="A224">UK Clinical Research Collaboration Centre of Excellence for Public Health (NI), Queens University of Belfast, Belfast, Northern Ireland</nlm:aff></affiliation></author><author><name sortKey="Keinanen Kiukaanniemi, Sirkka M" sort="Keinanen Kiukaanniemi, Sirkka M" uniqKey="Keinanen Kiukaanniemi S" first="Sirkka M" last="Keinanen-Kiukaanniemi">Sirkka M. Keinanen-Kiukaanniemi</name><affiliation><nlm:aff id="A225">Institute of Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A226">Unit of Primary Health Care/General Practice, Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S" last="Kooner">Jaspal S. Kooner</name><affiliation><nlm:aff id="A67">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A166">National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A227">Imperial College Healthcare NHS Trust, London W12 0HS, UK</nlm:aff></affiliation></author><author><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name><affiliation><nlm:aff id="A228">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA</nlm:aff></affiliation></author><author><name sortKey="Kovacs, Peter" sort="Kovacs, Peter" uniqKey="Kovacs P" first="Peter" last="Kovacs">Peter Kovacs</name><affiliation><nlm:aff id="A76">Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Kraja, Aldi T" sort="Kraja, Aldi T" uniqKey="Kraja A" first="Aldi T" last="Kraja">Aldi T. Kraja</name><affiliation><nlm:aff id="A46">Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name><affiliation><nlm:aff id="A229">Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A230">Department of Biological and Social Epidemiology, University of Essex, Wivenhoe Park, Colchester, Essex, CO4 3SQ, UK</nlm:aff></affiliation></author><author><name sortKey="Kuulasmaa, Kari" sort="Kuulasmaa, Kari" uniqKey="Kuulasmaa K" first="Kari" last="Kuulasmaa">Kari Kuulasmaa</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kuusisto, Johanna" sort="Kuusisto, Johanna" uniqKey="Kuusisto J" first="Johanna" last="Kuusisto">Johanna Kuusisto</name><affiliation><nlm:aff id="A231">Department of Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Lakka, Timo A" sort="Lakka, Timo A" uniqKey="Lakka T" first="Timo A" last="Lakka">Timo A. Lakka</name><affiliation><nlm:aff id="A100">Kuopio Research Institute of Exercise Medicine, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A232">Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A233">Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation><nlm:aff id="A23">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A229">Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="A234">Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI USA</nlm:aff></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:aff id="A235">Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine University of Tampere, FI-33520 Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Lyssenko, Valeriya" sort="Lyssenko, Valeriya" uniqKey="Lyssenko V" first="Valeriya" last="Lyssenko">Valeriya Lyssenko</name><affiliation><nlm:aff id="A236">Steno Diabetes Center A/S, Gentofte DK-2820, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A237">Lund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö 221 00, Sweden</nlm:aff></affiliation></author><author><name sortKey="M Nnisto, Satu" sort="M Nnisto, Satu" uniqKey="M Nnisto S" first="Satu" last="M Nnistö">Satu M Nnistö</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Marette, Andre" sort="Marette, Andre" uniqKey="Marette A" first="André" last="Marette">André Marette</name><affiliation><nlm:aff id="A238">Institut Universitaire de Cardiologie et de Pneumologie de Québec, Faculty of Medicine, Laval University, Quebec, QC G1V 0A6, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A239">Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada</nlm:aff></affiliation></author><author><name sortKey="Matise, Tara C" sort="Matise, Tara C" uniqKey="Matise T" first="Tara C" last="Matise">Tara C. Matise</name><affiliation><nlm:aff id="A42">Department of Genetics, Rutgers University, Piscataway, NJ USA</nlm:aff></affiliation></author><author><name sortKey="Mckenzie, Colin A" sort="Mckenzie, Colin A" uniqKey="Mckenzie C" first="Colin A" last="Mckenzie">Colin A. Mckenzie</name><affiliation><nlm:aff id="A209">UWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica</nlm:aff></affiliation></author><author><name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name><affiliation><nlm:aff id="A240">Department of Biostatistics, University of Washington, Seattle, WA 98195, USA</nlm:aff></affiliation></author><author><name sortKey="Musk, Arthur W" sort="Musk, Arthur W" uniqKey="Musk A" first="Arthur W" last="Musk">Arthur W. Musk</name><affiliation><nlm:aff id="A241">Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="Mohlenkamp, Stefan" sort="Mohlenkamp, Stefan" uniqKey="Mohlenkamp S" first="Stefan" last="Möhlenkamp">Stefan Möhlenkamp</name><affiliation><nlm:aff id="A203">Clinic of Cardiology, West-German Heart Centre, University Hospital Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Morris, Andrew D" sort="Morris, Andrew D" uniqKey="Morris A" first="Andrew D" last="Morris">Andrew D. Morris</name><affiliation><nlm:aff id="A85">Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK</nlm:aff></affiliation></author><author><name sortKey="Nelis, Mari" sort="Nelis, Mari" uniqKey="Nelis M" first="Mari" last="Nelis">Mari Nelis</name><affiliation><nlm:aff id="A9">Estonian Genome Center, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation></author><author><name sortKey="Ohlsson, Claes" sort="Ohlsson, Claes" uniqKey="Ohlsson C" first="Claes" last="Ohlsson">Claes Ohlsson</name><affiliation><nlm:aff id="A119">Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden</nlm:aff></affiliation></author><author><name sortKey="Oldehinkel, Albertine J" sort="Oldehinkel, Albertine J" uniqKey="Oldehinkel A" first="Albertine J" last="Oldehinkel">Albertine J. Oldehinkel</name><affiliation><nlm:aff id="A99">Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Ong, Ken K" sort="Ong, Ken K" uniqKey="Ong K" first="Ken K" last="Ong">Ken K. Ong</name><affiliation><nlm:aff id="A23">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A151">MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK</nlm:aff></affiliation></author><author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J" last="Palmer">Lyle J. Palmer</name><affiliation><nlm:aff id="A242">Epidemiology and Obstetrics & Gynaecology, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A243">Genetic Epidemiology & Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada</nlm:aff></affiliation></author><author><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W" last="Penninx">Brenda W. Penninx</name><affiliation><nlm:aff id="A200">Institute for Research in Extramural Medicine, Institute for Health and Care Research, VU University, 1081BT Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A244">Department of Psychiatry, Neuroscience Campus, VU University Amsterdam, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name><affiliation><nlm:aff id="A95">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A132">Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A145">Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P" last="Pramstaller">Peter P. Pramstaller</name><affiliation><nlm:aff id="A212">Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy - Affiliated Institute of the University of Lübeck, D-23562 Lübeck, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A245">Department of Neurology, General Central Hospital, Bolzano 39100, Italy</nlm:aff></affiliation></author><author><name sortKey="Raitakari, Olli T" sort="Raitakari, Olli T" uniqKey="Raitakari O" first="Olli T" last="Raitakari">Olli T. Raitakari</name><affiliation><nlm:aff id="A246">Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FI-20521 Turku, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A247">Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FI-20521 Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Rankinen, Tuomo" sort="Rankinen, Tuomo" uniqKey="Rankinen T" first="Tuomo" last="Rankinen">Tuomo Rankinen</name><affiliation><nlm:aff id="A248">Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA</nlm:aff></affiliation></author><author><name sortKey="Rao, Dc" sort="Rao, Dc" uniqKey="Rao D" first="Dc" last="Rao">Dc Rao</name><affiliation><nlm:aff id="A46">Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A60">Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A249">Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Rice, Treva K" sort="Rice, Treva K" uniqKey="Rice T" first="Treva K" last="Rice">Treva K. Rice</name><affiliation><nlm:aff id="A60">Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A249">Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name><affiliation><nlm:aff id="A136">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA 02215, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A250">Harvard Medical School, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Ritchie, Marylyn D" sort="Ritchie, Marylyn D" uniqKey="Ritchie M" first="Marylyn D." last="Ritchie">Marylyn D. Ritchie</name><affiliation><nlm:aff id="A251">Center for Systems Genomics, The Pennsylvania State University, University Park, PA 16802, USA</nlm:aff></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="A196">Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville TN 37203, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A252">Croatian Centre for Global Health, Faculty of Medicine, University of Split, 21000 Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J" last="Samani">Nilesh J. Samani</name><affiliation><nlm:aff id="A253">Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A254">National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, LE3 9QP, UK</nlm:aff></affiliation></author><author><name sortKey="Saramies, Jouko" sort="Saramies, Jouko" uniqKey="Saramies J" first="Jouko" last="Saramies">Jouko Saramies</name><affiliation><nlm:aff id="A255">South Carelia Central Hospital, 53130 Lappeenranta, Finland</nlm:aff></affiliation></author><author><name sortKey="Sarzynski, Mark A" sort="Sarzynski, Mark A" uniqKey="Sarzynski M" first="Mark A" last="Sarzynski">Mark A. Sarzynski</name><affiliation><nlm:aff id="A248">Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA</nlm:aff></affiliation></author><author><name sortKey="Schwarz, Peter Eh" sort="Schwarz, Peter Eh" uniqKey="Schwarz P" first="Peter Eh" last="Schwarz">Peter Eh Schwarz</name><affiliation><nlm:aff id="A97">Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A256">Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD), Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R" last="Shuldiner">Alan R. Shuldiner</name><affiliation><nlm:aff id="A257">Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A258">Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A259">Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center, Baltimore, MD 21201, USA</nlm:aff></affiliation></author><author><name sortKey="Staessen, Jan A" sort="Staessen, Jan A" uniqKey="Staessen J" first="Jan A" last="Staessen">Jan A. Staessen</name><affiliation><nlm:aff id="A260">Department of Epidemiology, Maastricht University, Maastricht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A261">Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, B-3000 Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Steinthorsdottir, Valgerdur" sort="Steinthorsdottir, Valgerdur" uniqKey="Steinthorsdottir V" first="Valgerdur" last="Steinthorsdottir">Valgerdur Steinthorsdottir</name><affiliation><nlm:aff id="A146">deCODE Genetics, Amgen inc., Reykjavik 101, Iceland</nlm:aff></affiliation></author><author><name sortKey="Stolk, Ronald P" sort="Stolk, Ronald P" uniqKey="Stolk R" first="Ronald P" last="Stolk">Ronald P. Stolk</name><affiliation><nlm:aff id="A107">Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Strauch, Konstantin" sort="Strauch, Konstantin" uniqKey="Strauch K" first="Konstantin" last="Strauch">Konstantin Strauch</name><affiliation><nlm:aff id="A69">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A131">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, D-81377 Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name><affiliation><nlm:aff id="A76">Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Tremblay, Angelo" sort="Tremblay, Angelo" uniqKey="Tremblay A" first="Angelo" last="Tremblay">Angelo Tremblay</name><affiliation><nlm:aff id="A262">Department of Kinesiology, Laval University, Quebec, QC G1V 0A6, Canada</nlm:aff></affiliation></author><author><name sortKey="Tremoli, Elena" sort="Tremoli, Elena" uniqKey="Tremoli E" first="Elena" last="Tremoli">Elena Tremoli</name><affiliation><nlm:aff id="A263">Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano & Centro Cardiologico Monzino, Instituto di Ricovero e Cura a Carattere Scientifico, Milan 20133, italy</nlm:aff></affiliation></author><author><name sortKey="Vohl, Marie Claude" sort="Vohl, Marie Claude" uniqKey="Vohl M" first="Marie-Claude" last="Vohl">Marie-Claude Vohl</name><affiliation><nlm:aff id="A239">Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A264">Department of Food Science and Nutrition, Laval University, Quebec, QC G1V 0A6, Canada</nlm:aff></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation><nlm:aff id="A62">Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A202">DZHK (Deutsches Zentrum für Herz-Kreislaufforschung – German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:aff id="A265">Department of Internal Medicine, University Hospital (CHUV) and University of Lausanne, 1011, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="A195">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK</nlm:aff></affiliation></author><author><name sortKey="Witteman, Jacqueline C" sort="Witteman, Jacqueline C" uniqKey="Witteman J" first="Jacqueline C" last="Witteman">Jacqueline C. Witteman</name><affiliation><nlm:aff id="A55">Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Adair, Linda S" sort="Adair, Linda S" uniqKey="Adair L" first="Linda S" last="Adair">Linda S. Adair</name><affiliation><nlm:aff id="A266">Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff></affiliation></author><author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name><affiliation><nlm:aff id="A267">Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A268">Ministry of Health, Victoria, Republic of Seychelles</nlm:aff></affiliation></author><author><name sortKey="Boehm, Bernhard O" sort="Boehm, Bernhard O" uniqKey="Boehm B" first="Bernhard O" last="Boehm">Bernhard O. Boehm</name><affiliation><nlm:aff id="A269">Lee Kong Chian School of Medicine, Imperial College London and Nanyang Technological University, Singapore, 637553 Singapore, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="A270">Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Bornstein, Stefan R" sort="Bornstein, Stefan R" uniqKey="Bornstein S" first="Stefan R" last="Bornstein">Stefan R. Bornstein</name><affiliation><nlm:aff id="A97">Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Bouchard, Claude" sort="Bouchard, Claude" uniqKey="Bouchard C" first="Claude" last="Bouchard">Claude Bouchard</name><affiliation><nlm:aff id="A248">Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA</nlm:aff></affiliation></author><author><name sortKey="Cauchi, Stephane" sort="Cauchi, Stephane" uniqKey="Cauchi S" first="Stéphane" last="Cauchi">Stéphane Cauchi</name><affiliation><nlm:aff id="A64">CNRS UMR 8199, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A65">European Genomic Institute for Diabetes, F-59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Université de Lille 2, F-59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Caulfield, Mark J" sort="Caulfield, Mark J" uniqKey="Caulfield M" first="Mark J" last="Caulfield">Mark J. Caulfield</name><affiliation><nlm:aff id="A271">Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK</nlm:aff></affiliation></author><author><name sortKey="Chambers, John C" sort="Chambers, John C" uniqKey="Chambers J" first="John C" last="Chambers">John C. Chambers</name><affiliation><nlm:aff id="A67">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A227">Imperial College Healthcare NHS Trust, London W12 0HS, UK</nlm:aff></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name><affiliation><nlm:aff id="A136">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA 02215, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A250">Harvard Medical School, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Cooper, Richard S" sort="Cooper, Richard S" uniqKey="Cooper R" first="Richard S" last="Cooper">Richard S. Cooper</name><affiliation><nlm:aff id="A144">Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, IL 61053, USA</nlm:aff></affiliation></author><author><name sortKey="Dedoussis, George" sort="Dedoussis, George" uniqKey="Dedoussis G" first="George" last="Dedoussis">George Dedoussis</name><affiliation><nlm:aff id="A114">Department of Dietetics-Nutrition, Harokopio University, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation><nlm:aff id="A61">Translational Gerontology Branch, National Institute on Aging, Baltimore MD 21225, USA</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="A58">Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A64">CNRS UMR 8199, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A65">European Genomic Institute for Diabetes, F-59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Université de Lille 2, F-59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Grabe, Hans Jorgen" sort="Grabe, Hans Jorgen" uniqKey="Grabe H" first="Hans-Jörgen" last="Grabe">Hans-Jörgen Grabe</name><affiliation><nlm:aff id="A272">Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS-Hospital Stralsund, D-17475 Greifswald, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A273">German Center for Neurodegenerative Diseases (DZNE), Rostock, Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name><affiliation><nlm:aff id="A10">Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hui, Jennie" sort="Hui, Jennie" uniqKey="Hui J" first="Jennie" last="Hui">Jennie Hui</name><affiliation><nlm:aff id="A71">PathWest Laboratory Medicine of Western Australia, NEDLANDS, Western Australia 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A191">Pathology and Laboratory Medicine, The University of Western Australia, Perth, Western Australia 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A274">School of Population Health, The University of Western Australia, Nedlands, Western Australia 6009, Australia</nlm:aff></affiliation></author><author><name sortKey="Hveem, Kristian" sort="Hveem, Kristian" uniqKey="Hveem K" first="Kristian" last="Hveem">Kristian Hveem</name><affiliation><nlm:aff id="A108">Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim 7489, Norway</nlm:aff></affiliation></author><author><name sortKey="Jockel, Karl Heinz" sort="Jockel, Karl Heinz" uniqKey="Jockel K" first="Karl-Heinz" last="Jöckel">Karl-Heinz Jöckel</name><affiliation><nlm:aff id="A28">Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name><affiliation><nlm:aff id="A229">Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK</nlm:aff></affiliation></author><author><name sortKey="Kuh, Diana" sort="Kuh, Diana" uniqKey="Kuh D" first="Diana" last="Kuh">Diana Kuh</name><affiliation><nlm:aff id="A151">MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK</nlm:aff></affiliation></author><author><name sortKey="Laakso, Markku" sort="Laakso, Markku" uniqKey="Laakso M" first="Markku" last="Laakso">Markku Laakso</name><affiliation><nlm:aff id="A231">Department of Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation><nlm:aff id="A275">Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA</nlm:aff></affiliation></author><author><name sortKey="M Rz, Winfried" sort="M Rz, Winfried" uniqKey="M Rz W" first="Winfried" last="M Rz">Winfried M Rz</name><affiliation><nlm:aff id="A49">Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A137">Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria</nlm:aff></affiliation><affiliation><nlm:aff id="A276">Synlab Academy, Synlab Services GmbH, Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Munroe, Patricia B" sort="Munroe, Patricia B" uniqKey="Munroe P" first="Patricia B" last="Munroe">Patricia B. Munroe</name><affiliation><nlm:aff id="A271">Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK</nlm:aff></affiliation></author><author><name sortKey="Nj Lstad, Inger" sort="Nj Lstad, Inger" uniqKey="Nj Lstad I" first="Inger" last="Nj Lstad">Inger Nj Lstad</name><affiliation><nlm:aff id="A150">Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway</nlm:aff></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A" last="Oostra">Ben A. Oostra</name><affiliation><nlm:aff id="A36">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A110">Center for Medical Sytems Biology, Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A277">Department of Clinical Genetics, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Palmer, Colin Na" sort="Palmer, Colin Na" uniqKey="Palmer C" first="Colin Na" last="Palmer">Colin Na Palmer</name><affiliation><nlm:aff id="A85">Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK</nlm:aff></affiliation></author><author><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L" last="Pedersen">Nancy L. Pedersen</name><affiliation><nlm:aff id="A20">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name><affiliation><nlm:aff id="A9">Estonian Genome Center, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A86">Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Perusse, Louis" sort="Perusse, Louis" uniqKey="Perusse L" first="Louis" last="Pérusse">Louis Pérusse</name><affiliation><nlm:aff id="A239">Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A262">Department of Kinesiology, Laval University, Quebec, QC G1V 0A6, Canada</nlm:aff></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation><nlm:aff id="A228">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA</nlm:aff></affiliation></author><author><name sortKey="Power, Chris" sort="Power, Chris" uniqKey="Power C" first="Chris" last="Power">Chris Power</name><affiliation><nlm:aff id="A218">Population, Policy, and Practice, University College London Institute of Child Health, London WC1N 1EH, UK</nlm:aff></affiliation></author><author><name sortKey="Quertermous, Thomas" sort="Quertermous, Thomas" uniqKey="Quertermous T" first="Thomas" last="Quertermous">Thomas Quertermous</name><affiliation><nlm:aff id="A278">Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Rauramaa, Rainer" sort="Rauramaa, Rainer" uniqKey="Rauramaa R" first="Rainer" last="Rauramaa">Rainer Rauramaa</name><affiliation><nlm:aff id="A100">Kuopio Research Institute of Exercise Medicine, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A233">Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="A54">Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Saaristo, Timo E" sort="Saaristo, Timo E" uniqKey="Saaristo T" first="Timo E" last="Saaristo">Timo E. Saaristo</name><affiliation><nlm:aff id="A279">Finnish Diabetes Association, Kirjoniementie 15, FI-33680 Tampere, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A280">Pirkanmaa Hospital District, Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Saleheen, Danish" sort="Saleheen, Danish" uniqKey="Saleheen D" first="Danish" last="Saleheen">Danish Saleheen</name><affiliation><nlm:aff id="A199">Biological Psychology, VU University Amsterdam, 1081BT Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A281">Center for Non-Communicable Diseases, Karatchi, Pakistan</nlm:aff></affiliation><affiliation><nlm:aff id="A282">Department of Medicine, University of Pennsylvania, Philadelphia, USA</nlm:aff></affiliation></author><author><name sortKey="Sinisalo, Juha" sort="Sinisalo, Juha" uniqKey="Sinisalo J" first="Juha" last="Sinisalo">Juha Sinisalo</name><affiliation><nlm:aff id="A283">Helsinki University Central Hospital Heart and Lung Center, Department of Medicine, Helsinki University Central Hospital, FI-00290 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Slagboom, P Eline" sort="Slagboom, P Eline" uniqKey="Slagboom P" first="P Eline" last="Slagboom">P Eline Slagboom</name><affiliation><nlm:aff id="A38">Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation><nlm:aff id="A107">Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D" last="Spector">Tim D. Spector</name><affiliation><nlm:aff id="A52">Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><nlm:aff id="A146">deCODE Genetics, Amgen inc., Reykjavik 101, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A284">Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland</nlm:aff></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation><nlm:aff id="A76">Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Tuomilehto, Jaakko" sort="Tuomilehto, Jaakko" uniqKey="Tuomilehto J" first="Jaakko" last="Tuomilehto">Jaakko Tuomilehto</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, FI-00271 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A285">Instituto de Investigacion Sanitaria del Hospital Universario LaPaz (IdiPAZ), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A286">Diabetes Research Group, King Abdulaziz University, 21589 Jeddah, Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="A287">Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G" last="Uitterlinden">André G. Uitterlinden</name><affiliation><nlm:aff id="A54">Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Uusitupa, Matti" sort="Uusitupa, Matti" uniqKey="Uusitupa M" first="Matti" last="Uusitupa">Matti Uusitupa</name><affiliation><nlm:aff id="A288">Department of Public Health and Clinical Nutrition, University of Eastern Finland, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A289">Research Unit, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation><nlm:aff id="A32">Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A53">Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A290">Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, 3501 DG Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Veronesi, Giovanni" sort="Veronesi, Giovanni" uniqKey="Veronesi G" first="Giovanni" last="Veronesi">Giovanni Veronesi</name><affiliation><nlm:aff id="A291">EPIMED Research Center, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy</nlm:aff></affiliation></author><author><name sortKey="Walker, Mark" sort="Walker, Mark" uniqKey="Walker M" first="Mark" last="Walker">Mark Walker</name><affiliation><nlm:aff id="A292">Institute of Cellular Medicine, Newcastle University, Newcastle NE1 7RU, UK</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A23">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A47">Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK</nlm:aff></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H-Erich" last="Wichmann">H-Erich Wichmann</name><affiliation><nlm:aff id="A293">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, D-85764 Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A294">Klinikum Grosshadern, D-81377 Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A295">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Abecasis, Goncalo R" sort="Abecasis, Goncalo R" uniqKey="Abecasis G" first="Goncalo R" last="Abecasis">Goncalo R. Abecasis</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Assimes, Themistocles L" sort="Assimes, Themistocles L" uniqKey="Assimes T" first="Themistocles L" last="Assimes">Themistocles L. Assimes</name><affiliation><nlm:aff id="A278">Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation><nlm:aff id="A296">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Boehnke, Michael" sort="Boehnke, Michael" uniqKey="Boehnke M" first="Michael" last="Boehnke">Michael Boehnke</name><affiliation><nlm:aff id="A8">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Borecki, Ingrid B" sort="Borecki, Ingrid B" uniqKey="Borecki I" first="Ingrid B" last="Borecki">Ingrid B. Borecki</name><affiliation><nlm:aff id="A46">Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA</nlm:aff></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name><affiliation><nlm:aff id="A27">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A142">William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ UK</nlm:aff></affiliation><affiliation><nlm:aff id="A297">Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, 21589 Jeddah, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Franke, Lude" sort="Franke, Lude" uniqKey="Franke L" first="Lude" last="Franke">Lude Franke</name><affiliation><nlm:aff id="A32">Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Frayling, Timothy M" sort="Frayling, Timothy M" uniqKey="Frayling T" first="Timothy M" last="Frayling">Timothy M. Frayling</name><affiliation><nlm:aff id="A30">Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK</nlm:aff></affiliation></author><author><name sortKey="Groop, Leif C" sort="Groop, Leif C" uniqKey="Groop L" first="Leif C" last="Groop">Leif C. Groop</name><affiliation><nlm:aff id="A86">Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A237">Lund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö 221 00, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="A6">Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A159">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Kaplan, Robert C" sort="Kaplan, Robert C" uniqKey="Kaplan R" first="Robert C" last="Kaplan">Robert C. Kaplan</name><affiliation><nlm:aff id="A298">Albert Einstein College of Medicine. Department of Epidemiology and Population Health, Belfer 1306, NY 10461, USA</nlm:aff></affiliation></author><author><name sortKey="O Onnell, Jeffrey R" sort="O Onnell, Jeffrey R" uniqKey="O Onnell J" first="Jeffrey R" last="O Onnell">Jeffrey R. O Onnell</name><affiliation><nlm:aff id="A257">Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A258">Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA</nlm:aff></affiliation></author><author><name sortKey="Qi, Lu" sort="Qi, Lu" uniqKey="Qi L" first="Lu" last="Qi">Lu Qi</name><affiliation><nlm:aff id="A6">Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Schlessinger, David" sort="Schlessinger, David" uniqKey="Schlessinger D" first="David" last="Schlessinger">David Schlessinger</name><affiliation><nlm:aff id="A133">Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA</nlm:aff></affiliation></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P" last="Strachan">David P. Strachan</name><affiliation><nlm:aff id="A299">Division of Population Health Sciences & Education, St George’s, University of London, London SW17 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation><nlm:aff id="A146">deCODE Genetics, Amgen inc., Reykjavik 101, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A284">Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A36">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A110">Center for Medical Sytems Biology, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Willer, Cristen J" sort="Willer, Cristen J" uniqKey="Willer C" first="Cristen J" last="Willer">Cristen J. Willer</name><affiliation><nlm:aff id="A31">Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A300">Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA</nlm:aff></affiliation></author><author><name sortKey="Visscher, Peter M" sort="Visscher, Peter M" uniqKey="Visscher P" first="Peter M" last="Visscher">Peter M. Visscher</name><affiliation><nlm:aff id="A301">Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A302">The University of Queensland Diamantina Institute, The Translation Research Institute, Brisbane 4012, Australia</nlm:aff></affiliation></author><author><name sortKey="Yang, Jian" sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name><affiliation><nlm:aff id="A301">Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A302">The University of Queensland Diamantina Institute, The Translation Research Institute, Brisbane 4012, Australia</nlm:aff></affiliation></author><author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N" last="Hirschhorn">Joel N. Hirschhorn</name><affiliation><nlm:aff id="A11">Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Department of Genetics, Harvard Medical School, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Zillikens, M Carola" sort="Zillikens, M Carola" uniqKey="Zillikens M" first="M Carola" last="Zillikens">M Carola Zillikens</name><affiliation><nlm:aff id="A54">Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I" last="Mccarthy">Mark I. Mccarthy</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A303">Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Trust, Oxford, OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Speliotes, Elizabeth K" sort="Speliotes, Elizabeth K" uniqKey="Speliotes E" first="Elizabeth K" last="Speliotes">Elizabeth K. Speliotes</name><affiliation><nlm:aff id="A33">Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109</nlm:aff></affiliation></author><author><name sortKey="North, Kari E" sort="North, Kari E" uniqKey="North K" first="Kari E" last="North">Kari E. North</name><affiliation><nlm:aff id="A15">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A304">Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA</nlm:aff></affiliation></author><author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S" last="Fox">Caroline S. Fox</name><affiliation><nlm:aff id="A18">National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham MA 01702, USA</nlm:aff></affiliation></author><author><name sortKey="Barroso, Ines" sort="Barroso, Ines" uniqKey="Barroso I" first="Inês" last="Barroso">Inês Barroso</name><affiliation><nlm:aff id="A27">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A305">University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 OQQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A306">NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 OQQ, UK</nlm:aff></affiliation></author><author><name sortKey="Franks, Paul W" sort="Franks, Paul W" uniqKey="Franks P" first="Paul W" last="Franks">Paul W. Franks</name><affiliation><nlm:aff id="A1">Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå 901 87, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden</nlm:aff></affiliation></author><author><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M" last="Heid">Iris M. Heid</name><affiliation><nlm:aff id="A4">Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A69">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Loos, Ruth Jf" sort="Loos, Ruth Jf" uniqKey="Loos R" first="Ruth Jf" last="Loos">Ruth Jf Loos</name><affiliation><nlm:aff id="A23">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A307">The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A308">The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A309">The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff></affiliation></author><author><name sortKey="Cupples, L Adrienne" sort="Cupples, L Adrienne" uniqKey="Cupples L" first="L Adrienne" last="Cupples">L Adrienne Cupples</name><affiliation><nlm:aff id="A17">Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A18">National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham MA 01702, USA</nlm:aff></affiliation></author><author><name sortKey="Morris, Andrew P" sort="Morris, Andrew P" uniqKey="Morris A" first="Andrew P" last="Morris">Andrew P. Morris</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Estonian Genome Center, University of Tartu, Tartu 51010, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A310">Department of Biostatistics, University of Liverpool, Liverpool L69 3GA, UK</nlm:aff></affiliation></author><author><name sortKey="Lindgren, Cecilia M" sort="Lindgren, Cecilia M" uniqKey="Lindgren C" first="Cecilia M" last="Lindgren">Cecilia M. Lindgren</name><affiliation><nlm:aff id="A7">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Mohlke, Karen L" sort="Mohlke, Karen L" uniqKey="Mohlke K" first="Karen L" last="Mohlke">Karen L. Mohlke</name><affiliation><nlm:aff id="A5">Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Nature</title><idno type="ISSN">0028-0836</idno><idno type="eISSN">1476-4687</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P4">Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, we conducted genome-wide association meta-analyses of waist and hip circumference-related traits in up to 224,459 individuals. We identified 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (WHRadjBMI) and an additional 19 loci newly associated with related waist and hip circumference measures (<italic>P</italic><5×10<sup>−8</sup>). Twenty of the 49 WHRadjBMI loci showed significant sexual dimorphism, 19 of which displayed a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation, and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Pischon, T" uniqKey="Pischon T">T Pischon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Rimm, Eb" uniqKey="Rimm E">EB Rimm</name></author><author><name sortKey="Stampfer, Mj" uniqKey="Stampfer M">MJ Stampfer</name></author><author><name sortKey="Willett, Wc" uniqKey="Willett W">WC Willett</name></author><author><name sortKey="Hu, Fb" uniqKey="Hu F">FB Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Canoy, D" uniqKey="Canoy D">D Canoy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snijder, Mb" 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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0410462</journal-id><journal-id journal-id-type="pubmed-jr-id">6011</journal-id><journal-id journal-id-type="nlm-ta">Nature</journal-id><journal-id journal-id-type="iso-abbrev">Nature</journal-id><journal-title-group><journal-title>Nature</journal-title></journal-title-group><issn pub-type="ppub">0028-0836</issn><issn pub-type="epub">1476-4687</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25673412</article-id><article-id pub-id-type="pmc">4338562</article-id><article-id pub-id-type="doi">10.1038/nature14132</article-id><article-id pub-id-type="manuscript">EMS61357</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>New genetic loci link adipose and insulin biology to body fat distribution</article-title></title-group><contrib-group><contrib contrib-type="author" 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rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Barroso</surname><given-names>Inês</given-names></name><xref ref-type="aff" rid="A27">27</xref><xref ref-type="aff" rid="A305">305</xref><xref ref-type="aff" rid="A306">306</xref></contrib><contrib contrib-type="author"><name><surname>Franks</surname><given-names>Paul W</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Ingelsson</surname><given-names>Erik</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A21">21</xref><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Heid</surname><given-names>Iris M</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A69">69</xref><xref ref-type="author-notes" rid="FN1">§</xref></contrib><contrib contrib-type="author"><name><surname>Loos</surname><given-names>Ruth JF</given-names></name><xref ref-type="aff" rid="A23">23</xref><xref ref-type="aff" rid="A307">307</xref><xref ref-type="aff" rid="A308">308</xref><xref ref-type="aff" rid="A309">309</xref><xref ref-type="author-notes" rid="FN1">§</xref></contrib><contrib contrib-type="author"><name><surname>Cupples</surname><given-names>L Adrienne</given-names></name><xref ref-type="aff" rid="A17">17</xref><xref ref-type="aff" rid="A18">18</xref><xref ref-type="author-notes" rid="FN1">§</xref></contrib><contrib contrib-type="author"><name><surname>Morris</surname><given-names>Andrew P</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A9">9</xref><xref ref-type="aff" rid="A310">310</xref><xref ref-type="author-notes" rid="FN1">§</xref></contrib><contrib contrib-type="author"><name><surname>Lindgren</surname><given-names>Cecilia M</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A12">12</xref><xref ref-type="author-notes" rid="FN1">§</xref></contrib><contrib contrib-type="author"><name><surname>Mohlke</surname><given-names>Karen L</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref ref-type="author-notes" rid="FN1">§</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå 901 87, Sweden</aff><aff id="A2"><label>2</label>Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden</aff><aff id="A3"><label>3</label>Department of Odontology, Umeå University, Umeå 901 85, Sweden</aff><aff id="A4"><label>4</label>Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany</aff><aff id="A5"><label>5</label>Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA</aff><aff id="A6"><label>6</label>Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA</aff><aff id="A7"><label>7</label>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</aff><aff id="A8"><label>8</label>Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA</aff><aff id="A9"><label>9</label>Estonian Genome Center, University of Tartu, Tartu 51010, Estonia</aff><aff id="A10"><label>10</label>Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden</aff><aff id="A11"><label>11</label>Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA 02115, USA</aff><aff id="A12"><label>12</label>Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA</aff><aff id="A13"><label>13</label>Department of Genetics, Harvard Medical School, Boston, MA 02115, USA</aff><aff id="A14"><label>14</label>Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby 2800, Denmark</aff><aff id="A15"><label>15</label>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA</aff><aff id="A16"><label>16</label>Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</aff><aff id="A17"><label>17</label>Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA</aff><aff id="A18"><label>18</label>National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham MA 01702, USA</aff><aff id="A19"><label>19</label>Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA</aff><aff id="A20"><label>20</label>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</aff><aff id="A21"><label>21</label>Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden</aff><aff id="A22"><label>22</label>Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden</aff><aff id="A23"><label>23</label>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK</aff><aff id="A24"><label>24</label>Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne 1010, Switzerland</aff><aff id="A25"><label>25</label>Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland</aff><aff id="A26"><label>26</label>Department of Medical Genetics, University of Lausanne, Lausanne 1005, Switzerland</aff><aff id="A27"><label>27</label>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</aff><aff id="A28"><label>28</label>Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany</aff><aff id="A29"><label>29</label>Clinical Epidemiology, Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany</aff><aff id="A30"><label>30</label>Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK</aff><aff id="A31"><label>31</label>Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA</aff><aff id="A32"><label>32</label>Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</aff><aff id="A33"><label>33</label>Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109</aff><aff id="A34"><label>34</label>Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA</aff><aff id="A35"><label>35</label>HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA</aff><aff id="A36"><label>36</label>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands</aff><aff id="A37"><label>37</label>Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Western Australia 6008, Australia</aff><aff id="A38"><label>38</label>Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands</aff><aff id="A39"><label>39</label>Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands</aff><aff id="A40"><label>40</label>Kidney Epidemiology and Cost Center, University of Michigan, Ann Arbor, MI 48109</aff><aff id="A41"><label>41</label>Department of Statistics & Biostatistics, Rutgers University, Piscataway, NJ USA</aff><aff id="A42"><label>42</label>Department of Genetics, Rutgers University, Piscataway, NJ USA</aff><aff id="A43"><label>43</label>Department of Human Genetics, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands</aff><aff id="A44"><label>44</label>Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA</aff><aff id="A45"><label>45</label>Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva 1211, Switzerland</aff><aff id="A46"><label>46</label>Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA</aff><aff id="A47"><label>47</label>Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK</aff><aff id="A48"><label>48</label>University Institute for Social and Preventative Medecine, Centre Hospitalier Universitaire Vaudois (CHUV), University of Lausanne, Lausanne 1005, Switzerland</aff><aff id="A49"><label>49</label>Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Germany</aff><aff id="A50"><label>50</label>Department of Internal Medicine II, Ulm University Medical Centre, D-89081 Ulm, Germany</aff><aff id="A51"><label>51</label>National Institute for Health and Welfare, FI-00271 Helsinki, Finland</aff><aff id="A52"><label>52</label>Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK</aff><aff id="A53"><label>53</label>Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands</aff><aff id="A54"><label>54</label>Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands</aff><aff id="A55"><label>55</label>Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</aff><aff id="A56"><label>56</label>Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands</aff><aff id="A57"><label>57</label>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK</aff><aff id="A58"><label>58</label>Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK</aff><aff id="A59"><label>59</label>University of Eastern Finland, FI-70210 Kuopio, Finland</aff><aff id="A60"><label>60</label>Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA</aff><aff id="A61"><label>61</label>Translational Gerontology Branch, National Institute on Aging, Baltimore MD 21225, USA</aff><aff id="A62"><label>62</label>Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany</aff><aff id="A63"><label>63</label>Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands</aff><aff id="A64"><label>64</label>CNRS UMR 8199, F-59019 Lille, France</aff><aff id="A65"><label>65</label>European Genomic Institute for Diabetes, F-59000 Lille, France</aff><aff id="A66"><label>66</label>Université de Lille 2, F-59000 Lille, France</aff><aff id="A67"><label>67</label>Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</aff><aff id="A68"><label>68</label>Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</aff><aff id="A69"><label>69</label>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany</aff><aff id="A70"><label>70</label>School of Health and Social Studies, Dalarna University, Falun, Sweden</aff><aff id="A71"><label>71</label>PathWest Laboratory Medicine of Western Australia, NEDLANDS, Western Australia 6009, Australia</aff><aff id="A72"><label>72</label>Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</aff><aff id="A73"><label>73</label>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA</aff><aff id="A74"><label>74</label>Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia</aff><aff id="A75"><label>75</label>Department of Medical Sciences, Endocrinology, Diabetes and Metabolism, Uppsala University, Uppsala 75185, Sweden</aff><aff id="A76"><label>76</label>Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany</aff><aff id="A77"><label>77</label>Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany</aff><aff id="A78"><label>78</label>Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands</aff><aff id="A79"><label>79</label>Inserm UMR991, Department of Endocrinology, University of Rennes, F-35000 Rennes, France</aff><aff id="A80"><label>80</label>LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</aff><aff id="A81"><label>81</label>USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines</aff><aff id="A82"><label>82</label>Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway</aff><aff id="A83"><label>83</label>Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK</aff><aff id="A84"><label>84</label>Information Sciences Institute, University of Southern California, Marina del Rey, California, USA</aff><aff id="A85"><label>85</label>Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK</aff><aff id="A86"><label>86</label>Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland</aff><aff id="A87"><label>87</label>Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA</aff><aff id="A88"><label>88</label>Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA</aff><aff id="A89"><label>89</label>Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany</aff><aff id="A90"><label>90</label>Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD 20892, USA</aff><aff id="A91"><label>91</label>Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala 75185, Sweden</aff><aff id="A92"><label>92</label>Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden</aff><aff id="A93"><label>93</label>Kaiser Permanente, Division of Research, Oakland, CA 94612, USA</aff><aff id="A94"><label>94</label>Service of Therapeutic Education for Diabetes, Obesity and Chronic Diseases, Geneva University Hospital, Geneva CH-1211, Switzerland</aff><aff id="A95"><label>95</label>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany</aff><aff id="A96"><label>96</label>German Center for Diabetes Research (DZD), Neuherberg, Germany</aff><aff id="A97"><label>97</label>Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany</aff><aff id="A98"><label>98</label>Department of Public Health and Clinical Medicine, Unit of Nutritional Research, Umeå University, Umeå 90187, Sweden</aff><aff id="A99"><label>99</label>Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands</aff><aff id="A100"><label>100</label>Kuopio Research Institute of Exercise Medicine, Kuopio, Finland</aff><aff id="A101"><label>101</label>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, Scotland, UK</aff><aff id="A102"><label>102</label>Hjelt Institute Department of Public Health, University of Helsinki, FI-00014 Helsinki, Finland</aff><aff id="A103"><label>103</label>Institute of Biomedicine, University of Oulu, Oulu, Finland</aff><aff id="A104"><label>104</label>Medical Research Center Oulu and Oulu University Hospital, Oulu, Finland</aff><aff id="A105"><label>105</label>Biocenter Oulu, University of Oulu, FI-90014 Oulu, Finland</aff><aff id="A106"><label>106</label>Faculty of Psychology and Education, VU University Amsterdam, Amsterdam, The Netherlands</aff><aff id="A107"><label>107</label>Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands</aff><aff id="A108"><label>108</label>Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim 7489, Norway</aff><aff id="A109"><label>109</label>Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84108, USA</aff><aff id="A110"><label>110</label>Center for Medical Sytems Biology, Leiden, The Netherlands</aff><aff id="A111"><label>111</label>Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany</aff><aff id="A112"><label>112</label>Department of Pulmonary Physiology and Sleep Medicine, Nedlands, Western Australia 6009, Australia</aff><aff id="A113"><label>113</label>School of Medicine and Pharmacology, University of Western Australia, Crawley 6009, Australia</aff><aff id="A114"><label>114</label>Department of Dietetics-Nutrition, Harokopio University, Athens, Greece</aff><aff id="A115"><label>115</label>Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany</aff><aff id="A116"><label>116</label>Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria</aff><aff id="A117"><label>117</label>Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany</aff><aff id="A118"><label>118</label>Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden</aff><aff id="A119"><label>119</label>Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden</aff><aff id="A120"><label>120</label>School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK</aff><aff id="A121"><label>121</label>Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany</aff><aff id="A122"><label>122</label>Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia</aff><aff id="A123"><label>123</label>Farr Institute of Health Informatics Research, University College London, London NW1 2DA, UK</aff><aff id="A124"><label>124</label>The Center for Observational Research, Amgen, Inc., Thousand Oaks, CA 91320, USA</aff><aff id="A125"><label>125</label>Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands</aff><aff id="A126"><label>126</label>Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</aff><aff id="A127"><label>127</label>Institute of Human Genetics, University of Bonn, Bonn, Germany</aff><aff id="A128"><label>128</label>Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Sardinia 09042, Italy</aff><aff id="A129"><label>129</label>Center for Evidence-based Healthcare, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany</aff><aff id="A130"><label>130</label>Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, D-81377 Munich, Germany</aff><aff id="A131"><label>131</label>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, D-81377 Munich, Germany</aff><aff id="A132"><label>132</label>Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany</aff><aff id="A133"><label>133</label>Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA</aff><aff id="A134"><label>134</label>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA</aff><aff id="A135"><label>135</label>Hypertension and Related Diseases Centre - AOU, University of Sassari Medical School, Sassari 07100, Italy</aff><aff id="A136"><label>136</label>Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA 02215, USA</aff><aff id="A137"><label>137</label>Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria</aff><aff id="A138"><label>138</label>Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A139"><label>139</label>Department of Medicine, University of Washington, Seattle, WA 98101, USA</aff><aff id="A140"><label>140</label>Icelandic Heart Association, Kopavogur 201, Iceland</aff><aff id="A141"><label>141</label>University of Iceland, Reykjavik 101, Iceland</aff><aff id="A142"><label>142</label>William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ UK</aff><aff id="A143"><label>143</label>Department of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala 75144, Sweden</aff><aff id="A144"><label>144</label>Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, IL 61053, USA</aff><aff id="A145"><label>145</label>Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany</aff><aff id="A146"><label>146</label>deCODE Genetics, Amgen inc., Reykjavik 101, Iceland</aff><aff id="A147"><label>147</label>Department of Cardiology, Medical University of Graz, Graz 8036, Austria</aff><aff id="A148"><label>148</label>Department of Child and Adolescent Psychiatry, Psychology, Erasmus MC University Medical Centre, 3000 CB Rotterdam, The Netherlands</aff><aff id="A149"><label>149</label>Department of Clinical Chemistry, Ulm University Medical Centre, D-89081 Ulm, Germany</aff><aff id="A150"><label>150</label>Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway</aff><aff id="A151"><label>151</label>MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK</aff><aff id="A152"><label>152</label>Diabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland</aff><aff id="A153"><label>153</label>Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea</aff><aff id="A154"><label>154</label>Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17176, Sweden</aff><aff id="A155"><label>155</label>Department of Medicine, Columbia University College of Physicians and Surgeons, New York NY, USA</aff><aff id="A156"><label>156</label>Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, MA</aff><aff id="A157"><label>157</label>Massachusetts General Hospital, Boston, MA, USA</aff><aff id="A158"><label>158</label>State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China</aff><aff id="A159"><label>159</label>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</aff><aff id="A160"><label>160</label>NIHR Oxford Biomedical Research Centre, OUH Trust, Oxford OX3 7LE, UK</aff><aff id="A161"><label>161</label>Harvard School of Public Health, Department of Biostatistics, Harvard University, Boston, MA 2115, USA</aff><aff id="A162"><label>162</label>Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, New Haven CT, USA</aff><aff id="A163"><label>163</label>College of Information Science and Technology, Dalian Maritime University, Dalian, Liaoning 116026, China</aff><aff id="A164"><label>164</label>Nephrology Research, Centre for Public Health, Queen’s University of Belfast, Belfast, Co. Down BT9 7AB, UK</aff><aff id="A165"><label>165</label>University of Ottawa Heart Institute, Ottawa K1Y 4W7, Canada</aff><aff id="A166"><label>166</label>National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK</aff><aff id="A167"><label>167</label>QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia</aff><aff id="A168"><label>168</label>Section of General Internal Medicine, Boston University School of Medicine, Boston, MA 02118, USA</aff><aff id="A169"><label>169</label>Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK</aff><aff id="A170"><label>170</label>MRC Harwell, Harwell Science and Innovation Campus, Harwell, UK</aff><aff id="A171"><label>171</label>Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia</aff><aff id="A172"><label>172</label>Department of Biomedical Engineering and Computational Science, Aalto University School of Science, Helsinki, Finland</aff><aff id="A173"><label>173</label>Department of Medicine, Division of Nephrology, Helsinki University Central Hospital, FI-00290 Helsinki, Finland</aff><aff id="A174"><label>174</label>Folkhälsan Institute of Genetics, Folkhälsan Research Center, FI-00290 Helsinki, Finland</aff><aff id="A175"><label>175</label>Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10580, USA</aff><aff id="A176"><label>176</label>Computer Science Department, Tecnológico de Monterrey, Atizapán de Zaragoza, 52926, Mexico</aff><aff id="A177"><label>177</label>Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Oxford OX3 7BN, UK</aff><aff id="A178"><label>178</label>Adiponectin Genetic Consortium</aff><aff id="A179"><label>179</label>Membership to this consortium is provided below</aff><aff id="A180"><label>180</label>The GEnetic Factors for OSteoporosis Consortium</aff><aff id="A181"><label>181</label>GEnetics of Nephropathy - an International Effort Consortium</aff><aff id="A182"><label>182</label>The Global Lipids Genetics Consortium</aff><aff id="A183"><label>183</label>The International Consortium for Blood Pressure Genome-Wide Association Studies</aff><aff id="A184"><label>184</label>The LifeLines Cohort Study, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands</aff><aff id="A185"><label>185</label>Meta-Analyses of Glucose and Insulin-related traits Consortium Investigators</aff><aff id="A186"><label>186</label>The Multiple Tissue Human Expression Resource Consortium</aff><aff id="A187"><label>187</label>Population Architecture using Genomics and Epidemiology Consortium</aff><aff id="A188"><label>188</label>Institut Pasteur de Lille; INSERM, U744; Université de Lille 2; F-59000 Lille, France</aff><aff id="A189"><label>189</label>Department of Epidemiology and Public Health, EA3430, University of Strasbourg, Faculty of Medicine, Strasbourg, France</aff><aff id="A190"><label>190</label>Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands</aff><aff id="A191"><label>191</label>Pathology and Laboratory Medicine, The University of Western Australia, Perth, Western Australia 6009, Australia</aff><aff id="A192"><label>192</label>Cedars-Sinai Diabetes and Obesity Research Institute, Los Angeles, CA, USA</aff><aff id="A193"><label>193</label>Clinical Pharmacology Unit, University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK</aff><aff id="A194"><label>194</label>Service of Nephrology, Department of Medicine, Lausanne University Hospital (CHUV), Lausanne 1005, Switzerland</aff><aff id="A195"><label>195</label>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK</aff><aff id="A196"><label>196</label>Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville TN 37203, USA</aff><aff id="A197"><label>197</label>Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA</aff><aff id="A198"><label>198</label>Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</aff><aff id="A199"><label>199</label>Biological Psychology, VU University Amsterdam, 1081BT Amsterdam, The Netherlands</aff><aff id="A200"><label>200</label>Institute for Research in Extramural Medicine, Institute for Health and Care Research, VU University, 1081BT Amsterdam, The Netherlands</aff><aff id="A201"><label>201</label>Department of Internal Medicine B, University Medicine Greifswald, D-17475 Greifswald, Germany</aff><aff id="A202"><label>202</label>DZHK (Deutsches Zentrum für Herz-Kreislaufforschung – German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany</aff><aff id="A203"><label>203</label>Clinic of Cardiology, West-German Heart Centre, University Hospital Essen, Essen, Germany</aff><aff id="A204"><label>204</label>Department of General Practice and Primary Health Care, University of Helsinki, FI-00290 Helsinki, Finland</aff><aff id="A205"><label>205</label>Unit of General Practice, Helsinki University Central Hospital, Helsinki 00290, Finland</aff><aff id="A206"><label>206</label>Department of Internal Medicine, University of Pisa, Pisa, Italy</aff><aff id="A207"><label>207</label>National Research Council Institute of Clinical Physiology, University of Pisa, Pisa, Italy</aff><aff id="A208"><label>208</label>Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, France</aff><aff id="A209"><label>209</label>UWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica</aff><aff id="A210"><label>210</label>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</aff><aff id="A211"><label>211</label>Institute of Biomedical & Clinical Science, University of Exeter, Barrack Road, Exeter EX2 5DW, UK</aff><aff id="A212"><label>212</label>Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy - Affiliated Institute of the University of Lübeck, D-23562 Lübeck, Germany</aff><aff id="A213"><label>213</label>Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK</aff><aff id="A214"><label>214</label>Centre for Cardiovascular Genetics, Institute Cardiovascular Sciences, University College London, London WC1E 6JJ, UK</aff><aff id="A215"><label>215</label>Sansom Institute for Health Research, University of South Australia, Adelaide 5000, South Australia, Australia</aff><aff id="A216"><label>216</label>School of Population Health, University of South Australia, Adelaide 5000, South Australia, Australia</aff><aff id="A217"><label>217</label>South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia</aff><aff id="A218"><label>218</label>Population, Policy, and Practice, University College London Institute of Child Health, London WC1N 1EH, UK</aff><aff id="A219"><label>219</label>Hannover Unified Biobank, Hannover Medical School, Hannover, D-30625 Hannover, Germany</aff><aff id="A220"><label>220</label>National Institute for Health and Welfare, FI-90101 Oulu, Finland</aff><aff id="A221"><label>221</label>MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, UK</aff><aff id="A222"><label>222</label>Unit of Primary Care, Oulu University Hospital, FI-90220 Oulu, Finland</aff><aff id="A223"><label>223</label>Institute of Health Sciences, FI-90014 University of Oulu, Finland</aff><aff id="A224"><label>224</label>UK Clinical Research Collaboration Centre of Excellence for Public Health (NI), Queens University of Belfast, Belfast, Northern Ireland</aff><aff id="A225"><label>225</label>Institute of Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland</aff><aff id="A226"><label>226</label>Unit of Primary Health Care/General Practice, Oulu University Hospital, Oulu, Finland</aff><aff id="A227"><label>227</label>Imperial College Healthcare NHS Trust, London W12 0HS, UK</aff><aff id="A228"><label>228</label>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA</aff><aff id="A229"><label>229</label>Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK</aff><aff id="A230"><label>230</label>Department of Biological and Social Epidemiology, University of Essex, Wivenhoe Park, Colchester, Essex, CO4 3SQ, UK</aff><aff id="A231"><label>231</label>Department of Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland</aff><aff id="A232"><label>232</label>Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland</aff><aff id="A233"><label>233</label>Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland</aff><aff id="A234"><label>234</label>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI USA</aff><aff id="A235"><label>235</label>Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine University of Tampere, FI-33520 Tampere, Finland</aff><aff id="A236"><label>236</label>Steno Diabetes Center A/S, Gentofte DK-2820, Denmark</aff><aff id="A237"><label>237</label>Lund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö 221 00, Sweden</aff><aff id="A238"><label>238</label>Institut Universitaire de Cardiologie et de Pneumologie de Québec, Faculty of Medicine, Laval University, Quebec, QC G1V 0A6, Canada</aff><aff id="A239"><label>239</label>Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada</aff><aff id="A240"><label>240</label>Department of Biostatistics, University of Washington, Seattle, WA 98195, USA</aff><aff id="A241"><label>241</label>Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia</aff><aff id="A242"><label>242</label>Epidemiology and Obstetrics & Gynaecology, University of Toronto, Toronto, Ontario, Canada</aff><aff id="A243"><label>243</label>Genetic Epidemiology & Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada</aff><aff id="A244"><label>244</label>Department of Psychiatry, Neuroscience Campus, VU University Amsterdam, Amsterdam, The Netherlands</aff><aff id="A245"><label>245</label>Department of Neurology, General Central Hospital, Bolzano 39100, Italy</aff><aff id="A246"><label>246</label>Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FI-20521 Turku, Finland</aff><aff id="A247"><label>247</label>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FI-20521 Turku, Finland</aff><aff id="A248"><label>248</label>Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA</aff><aff id="A249"><label>249</label>Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA</aff><aff id="A250"><label>250</label>Harvard Medical School, Boston, MA 02115, USA</aff><aff id="A251"><label>251</label>Center for Systems Genomics, The Pennsylvania State University, University Park, PA 16802, USA</aff><aff id="A252"><label>252</label>Croatian Centre for Global Health, Faculty of Medicine, University of Split, 21000 Split, Croatia</aff><aff id="A253"><label>253</label>Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK</aff><aff id="A254"><label>254</label>National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, LE3 9QP, UK</aff><aff id="A255"><label>255</label>South Carelia Central Hospital, 53130 Lappeenranta, Finland</aff><aff id="A256"><label>256</label>Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD), Dresden, Germany</aff><aff id="A257"><label>257</label>Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA</aff><aff id="A258"><label>258</label>Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA</aff><aff id="A259"><label>259</label>Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center, Baltimore, MD 21201, USA</aff><aff id="A260"><label>260</label>Department of Epidemiology, Maastricht University, Maastricht, The Netherlands</aff><aff id="A261"><label>261</label>Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, B-3000 Leuven, Belgium</aff><aff id="A262"><label>262</label>Department of Kinesiology, Laval University, Quebec, QC G1V 0A6, Canada</aff><aff id="A263"><label>263</label>Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano & Centro Cardiologico Monzino, Instituto di Ricovero e Cura a Carattere Scientifico, Milan 20133, italy</aff><aff id="A264"><label>264</label>Department of Food Science and Nutrition, Laval University, Quebec, QC G1V 0A6, Canada</aff><aff id="A265"><label>265</label>Department of Internal Medicine, University Hospital (CHUV) and University of Lausanne, 1011, Switzerland</aff><aff id="A266"><label>266</label>Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA</aff><aff id="A267"><label>267</label>Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland</aff><aff id="A268"><label>268</label>Ministry of Health, Victoria, Republic of Seychelles</aff><aff id="A269"><label>269</label>Lee Kong Chian School of Medicine, Imperial College London and Nanyang Technological University, Singapore, 637553 Singapore, Singapore</aff><aff id="A270"><label>270</label>Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany</aff><aff id="A271"><label>271</label>Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK</aff><aff id="A272"><label>272</label>Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS-Hospital Stralsund, D-17475 Greifswald, Germany</aff><aff id="A273"><label>273</label>German Center for Neurodegenerative Diseases (DZNE), Rostock, Greifswald, D-17475 Greifswald, Germany</aff><aff id="A274"><label>274</label>School of Population Health, The University of Western Australia, Nedlands, Western Australia 6009, Australia</aff><aff id="A275"><label>275</label>Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA</aff><aff id="A276"><label>276</label>Synlab Academy, Synlab Services GmbH, Mannheim, Germany</aff><aff id="A277"><label>277</label>Department of Clinical Genetics, Erasmus MC University Medical Center, Rotterdam, The Netherlands</aff><aff id="A278"><label>278</label>Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA</aff><aff id="A279"><label>279</label>Finnish Diabetes Association, Kirjoniementie 15, FI-33680 Tampere, Finland</aff><aff id="A280"><label>280</label>Pirkanmaa Hospital District, Tampere, Finland</aff><aff id="A281"><label>281</label>Center for Non-Communicable Diseases, Karatchi, Pakistan</aff><aff id="A282"><label>282</label>Department of Medicine, University of Pennsylvania, Philadelphia, USA</aff><aff id="A283"><label>283</label>Helsinki University Central Hospital Heart and Lung Center, Department of Medicine, Helsinki University Central Hospital, FI-00290 Helsinki, Finland</aff><aff id="A284"><label>284</label>Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland</aff><aff id="A285"><label>285</label>Instituto de Investigacion Sanitaria del Hospital Universario LaPaz (IdiPAZ), Madrid, Spain</aff><aff id="A286"><label>286</label>Diabetes Research Group, King Abdulaziz University, 21589 Jeddah, Saudi Arabia</aff><aff id="A287"><label>287</label>Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria</aff><aff id="A288"><label>288</label>Department of Public Health and Clinical Nutrition, University of Eastern Finland, Finland</aff><aff id="A289"><label>289</label>Research Unit, Kuopio University Hospital, Kuopio, Finland</aff><aff id="A290"><label>290</label>Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, 3501 DG Utrecht, The Netherlands</aff><aff id="A291"><label>291</label>EPIMED Research Center, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy</aff><aff id="A292"><label>292</label>Institute of Cellular Medicine, Newcastle University, Newcastle NE1 7RU, UK</aff><aff id="A293"><label>293</label>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, D-85764 Munich, Germany</aff><aff id="A294"><label>294</label>Klinikum Grosshadern, D-81377 Munich, Germany</aff><aff id="A295"><label>295</label>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany</aff><aff id="A296"><label>296</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA</aff><aff id="A297"><label>297</label>Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, 21589 Jeddah, Saudi Arabia</aff><aff id="A298"><label>298</label>Albert Einstein College of Medicine. Department of Epidemiology and Population Health, Belfer 1306, NY 10461, USA</aff><aff id="A299"><label>299</label>Division of Population Health Sciences & Education, St George’s, University of London, London SW17 0RE, UK</aff><aff id="A300"><label>300</label>Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA</aff><aff id="A301"><label>301</label>Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia</aff><aff id="A302"><label>302</label>The University of Queensland Diamantina Institute, The Translation Research Institute, Brisbane 4012, Australia</aff><aff id="A303"><label>303</label>Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Trust, Oxford, OX3 7LJ, UK</aff><aff id="A304"><label>304</label>Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA</aff><aff id="A305"><label>305</label>University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 OQQ, UK</aff><aff id="A306"><label>306</label>NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 OQQ, UK</aff><aff id="A307"><label>307</label>The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</aff><aff id="A308"><label>308</label>The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</aff><aff id="A309"><label>309</label>The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</aff><aff id="A310"><label>310</label>Department of Biostatistics, University of Liverpool, Liverpool L69 3GA, UK</aff><author-notes><corresp id="CR1">Correspondence and requests for materials should be addressed to K.L.M. (<email>mohlke@med.unc.edu</email>) or C.M.L. (<email>celi@well.ox.ac.uk</email>)</corresp><fn id="FN1"><label>§</label><p id="P1">These authors jointly directed this work.</p></fn><fn id="FN3"><p id="P2"><bold>Author Contributions</bold> See the <xref ref-type="supplementary-material" rid="SD2">Supplementary Note</xref> for Author Contributions.</p></fn><fn id="FN4"><p id="P3"><bold>Author Information</bold> Summary results are available at <ext-link ext-link-type="uri" xlink:href="http://www.broadinstitute.org/collaboration/giant/">http://www.broadinstitute.org/collaboration/giant/</ext-link>. G.T., V.S., U.T., and K.S. are employed by deCODE Genetics/Amgen, Inc. I.B. and spouse own stock in GlaxoSmithKline and Incyte, Ltd. C.B. is a consultant for Weight Watchers, Pathway Genomics, NIKE, and Gatorade PepsiCo.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>16</day><month>12</month><year>2014</year></pub-date><pub-date pub-type="ppub"><day>12</day><month>2</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>12</day><month>8</month><year>2015</year></pub-date><volume>518</volume><issue>7538</issue><fpage>187</fpage><lpage>196</lpage><pmc-comment>elocation-id from pubmed: 10.1038/nature14132</pmc-comment>
<permissions><license license-type="permissions-link"><license-p>Reprints and permissions information is available online at
<ext-link ext-link-type="uri" xlink:href="http://www.nature.com/reprints">www.nature.com/reprints</ext-link>.
</license-p></license><license><license-p>Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:<uri xlink:type="simple" xlink:href="http://www.nature.com/authors/editorial_policies/license.html#terms">http://www.nature.com/authors/editorial_policies/license.html#terms</uri></license-p></license></permissions><abstract><p id="P4">Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, we conducted genome-wide association meta-analyses of waist and hip circumference-related traits in up to 224,459 individuals. We identified 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (WHRadjBMI) and an additional 19 loci newly associated with related waist and hip circumference measures (<italic>P</italic><5×10<sup>−8</sup>). Twenty of the 49 WHRadjBMI loci showed significant sexual dimorphism, 19 of which displayed a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation, and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.</p></abstract></article-meta></front><body><p id="P5">Depot-specific accumulation of fat, particularly in the central abdomen, confers an elevated risk of metabolic and cardiovascular diseases and mortality<sup><xref rid="R1" ref-type="bibr">1</xref></sup>. An easily accessible measure of body fat distribution is waist-to-hip ratio (WHR), a comparison of waist and hip circumferences. A larger WHR indicates more intra-abdominal fat deposition and is associated with higher risk for type 2 diabetes (T2D) and cardiovascular disease<sup><xref rid="R2" ref-type="bibr">2</xref>,<xref rid="R3" ref-type="bibr">3</xref></sup>. Conversely, a smaller WHR indicates greater gluteal fat accumulation and is associated with lower risk for T2D, hypertension, dyslipidemia, and mortality<sup><xref rid="R4" ref-type="bibr">4</xref>-<xref rid="R6" ref-type="bibr">6</xref></sup>. Our previous genome-wide association study (GWAS) meta-analyses have identified loci for WHR after adjusting for body mass index (WHRadjBMI)<sup><xref rid="R7" ref-type="bibr">7</xref>,<xref rid="R8" ref-type="bibr">8</xref></sup>. These loci are enriched for association with other metabolic traits<sup><xref rid="R7" ref-type="bibr">7</xref>,<xref rid="R8" ref-type="bibr">8</xref></sup> and show that different fat distribution patterns can have distinct genetic components<sup><xref rid="R9" ref-type="bibr">9</xref>,<xref rid="R10" ref-type="bibr">10</xref></sup>.</p><p id="P6">To further elucidate the genetic architecture of fat distribution and to increase our understanding of molecular connections with cardiometabolic traits, we performed a meta-analysis of WHRadjBMI associations in 142,762 individuals with GWAS data and 81,697 individuals genotyped with the Metabochip<sup><xref rid="R11" ref-type="bibr">11</xref></sup>, all from the Genetic Investigation of ANthropometric Traits (GIANT) Consortium. Given the marked sexual dimorphism previously observed among established WHRadjBMI loci<sup><xref rid="R7" ref-type="bibr">7</xref>,<xref rid="R8" ref-type="bibr">8</xref></sup>, we performed analyses in men and women separately, the results of which were subsequently combined. To more fully characterize the genetic determinants of specific aspects of body fat distribution, we performed secondary GWAS meta-analyses for five additional traits: unadjusted WHR, BMI-adjusted and unadjusted waist (WCadjBMI and WC) and hip circumferences (HIPadjBMI and HIP). We evaluated the associated loci to understand their contributions to variation in fat distribution and adipose tissue biology, and their molecular links to cardiometabolic traits.</p><sec sec-type="results" id="S1"><title>RESULTS</title><sec id="S2"><title>New loci associated with WHRadjBMI</title><p id="P7">We performed meta-analyses of GWAS of WHRadjBMI in up to 142,762 individuals of European ancestry from 57 new or previously described GWAS<sup><xref rid="R7" ref-type="bibr">7</xref></sup>, and separately in up to an additional 67,326 European ancestry individuals from 44 Metabochip studies (<xref ref-type="fig" rid="F3">Extended Data Fig. 1</xref>; <xref ref-type="supplementary-material" rid="SD2">Supplementary Tables 1-3</xref>). The combination of these two meta-analyses included up to 2,542,447 autosomal SNPs in up to 210,088 European ancestry individuals. We defined new loci based on genome-wide significant association (<italic>P<</italic>5 × 10<sup>−8</sup> after genomic control correction at both the study-specific and meta-analytic levels) and distance (>500 kb) from previously established loci<sup><xref rid="R7" ref-type="bibr">7</xref>,<xref rid="R8" ref-type="bibr">8</xref></sup>.</p><p id="P8">We identified 49 loci for WHRadjBMI, 33 of which were new and 16 previously described<sup><xref rid="R7" ref-type="bibr">7</xref>,<xref rid="R8" ref-type="bibr">8</xref></sup>. Of these, a European ancestry sex-combined analysis identified 39 loci, 24 of which were new (<xref ref-type="table" rid="T1">Table 1</xref>, <xref ref-type="supplementary-material" rid="SD2">Supplementary Table 4, and Supplementary Figs. 1-3</xref>)<sup><xref rid="R7" ref-type="bibr">7</xref>,<xref rid="R8" ref-type="bibr">8</xref></sup>. European ancestry sex-specific analyses identified nine additional loci, eight of which were new and significant in women but not in men (all <italic>P</italic><sub>men</sub>>0.05; <xref ref-type="table" rid="T1">Table 1</xref>, <xref ref-type="supplementary-material" rid="SD2">Supplementary Fig. 4</xref>). The addition of 14,371 individuals of non-European ancestry genotyped on Metabochip identified one additional locus in women (rs1534696, near <italic>SNX10, P</italic><sub>women</sub>=2.1×10<sup>−8</sup>, <italic>P</italic><sub>men</sub>=0.26, <xref ref-type="table" rid="T1">Table 1</xref>, <xref ref-type="supplementary-material" rid="SD2">Supplementary Tables 1-3</xref>), with no evidence of heterogeneity across ancestries (<italic>P</italic><sub>het</sub>=0.86, <xref ref-type="supplementary-material" rid="SD2">Supplementary Note</xref>).</p></sec><sec id="S3"><title>Genetic architecture of WHRadjBMI</title><p id="P9">To evaluate sexual dimorphism, we compared sex-specific effect size estimates of the 49 WHRadjBMI lead SNPs. The effect estimates were significantly different (<italic>P</italic><sub>difference</sub><0.05/49=0.001) at 20 SNPs, 19 of which showed larger effects in women (<xref ref-type="table" rid="T1">Table 1</xref>, <xref ref-type="fig" rid="F4">Extended Data Fig. 2a</xref>), similar to previous findings<sup><xref rid="R7" ref-type="bibr">7</xref>,<xref rid="R8" ref-type="bibr">8</xref></sup>. The only SNP that showed a larger effect in men mapped near <italic>GDF5</italic> (rs224333, <italic>β</italic><sub>men</sub>=0.036 and <italic>P=</italic>9.0×10<sup>−12</sup>, <italic>β</italic><sub>women</sub>=0.009 and <italic>P</italic>=0.074, <italic>P</italic><sub>difference</sub>= 6.4 × 10<sup>−5</sup>), a locus previously associated with height (rs6060369, <italic>r</italic><sup>2</sup>=0.96 and rs143384, <italic>r</italic><sup>2</sup>=0.96, 1000 Genomes Project CEU), though without significant differences between sexes<sup><xref rid="R12" ref-type="bibr">12</xref>,<xref rid="R13" ref-type="bibr">13</xref></sup>. Consistent with the larger number of loci identified in women, variance component analyses demonstrated a significantly larger heritability (<italic>h<sup>2</sup></italic>) of WHRadjBMI in women than men in the Framingham Heart (<italic>h</italic><sup>2</sup><sub>women</sub>=0.46, <italic>h</italic><sup>2</sup><sub>men</sub>=0.19, <italic>P</italic><sub>difference</sub>=0.0037) and TwinGene studies (<italic>h</italic><sup>2</sup><sub>women</sub>=0.56, <italic>h</italic><sup>2</sup><sub>men</sub>=0.32, <italic>P</italic><sub>difference</sub>=0.001, <xref ref-type="supplementary-material" rid="SD2">Supplementary Table 5</xref>, <xref ref-type="fig" rid="F4">Extended Data Fig. 2b</xref>).</p><p id="P10">To identify multiple association signals within observed loci, we performed approximate conditional analyses of the sex-combined and sex-specific summary statistics using GCTA<sup><xref rid="R14" ref-type="bibr">14</xref></sup> (<xref ref-type="supplementary-material" rid="SD2">Supplementary Note</xref>). Multiple signals (<italic>P<</italic>5×10<sup>−8</sup>) were identified at nine loci (<xref ref-type="table" rid="T4">Extended Data Table 1</xref>). Fitting SNPs jointly identified different lead SNPs in the sex-specific and sex-combined analyses. For example, the <italic>MAP3K1-ANKRD55</italic> locus showed near-independent (linkage disequilibrium (LD) <italic>r</italic><sup>2</sup><0.06) SNPs 54 kb apart that were significant only in women (rs3936510) or only in men (rs459193, <xref ref-type="table" rid="T4">Extended Data Table 1</xref>, <xref ref-type="supplementary-material" rid="SD2">Supplementary Table 4</xref>). Other signals are more complex. The <italic>TBX15-WARS2</italic> locus showed different but correlated lead SNPs in men and women near <italic>WARS2</italic> (<italic>r</italic><sup>2</sup>=0.43), an independent signal near <italic>TBX15,</italic> and a distant independent signal near <italic>SPAG17</italic> (<xref ref-type="fig" rid="F1">Fig. 1</xref>). At the <italic>HOXC</italic> gene cluster, conditional analyses identified independent (<italic>r</italic><sup>2<</sup>0.01) SNPs ~80 kb apart near <italic>HOXC12-HOXC13-HOTAIR</italic> and near <italic>HOXC4-HOXC6</italic> (<xref ref-type="fig" rid="F1">Fig. 1</xref>). These results suggest that association signals mapping to the same locus might act on different underlying genes and may not be relevant to the same sex.</p><p id="P11">We assessed the aggregate effects of the primary association signals at the 49 WHRadjBMI loci by calculating sex-combined and sex-specific risk based on genotypes of the lead SNPs. In a linear regression model, the risk scores were associated with WHRadjBMI, with a stronger effect in women than in men (overall effect per allele β=0.001, <italic>P</italic>=6.7×10<sup>−4</sup>, women β=0.002, <italic>P</italic>=1.0×10<sup>−11</sup>, men β=7.0×10<sup>−4</sup>, <italic>P</italic>=0.02, <xref ref-type="fig" rid="F5">Extended Data Fig. 3</xref>, <xref ref-type="supplementary-material" rid="SD2">Supplementary Note</xref>). The 49 SNPs explained 1.4% of the variance in WHRadjBMI overall, and more in women (2.4%) than in men (0.8%) (<xref ref-type="supplementary-material" rid="SD2">Supplementary Table 6</xref>). Compared to the 16 previously reported loci<sup><xref rid="R7" ref-type="bibr">7</xref>,<xref rid="R8" ref-type="bibr">8</xref></sup>, the new loci almost doubled the explained variance in women and tripled that in men. We further estimated that the sex-combined variance explained by all HapMap SNPs<sup><xref rid="R15" ref-type="bibr">15</xref></sup> (h<sup>2</sup><sub>G</sub>) is 12.1% (SE=2.9%).</p><p id="P12">At 17 loci with high-density coverage on the Metabochip<sup><xref rid="R11" ref-type="bibr">11</xref></sup>, we used association summary statistics to define credible sets of SNPs with a high probability of containing a likely functional variant. The 99% credible sets at seven loci spanned <20 kb, and at <italic>HOXC13</italic> included only a single noncoding SNP (<xref ref-type="supplementary-material" rid="SD2">Supplementary Table 7, Supplementary Fig. 5</xref>). Imputation up to higher density reference panels will provide greater coverage and may have more potential to localize functional variants.</p></sec><sec id="S4"><title>WHRadjBMI variants and other traits</title><p id="P13">Given the epidemiological correlations between central obesity and other anthropometric and cardiometabolic measures and diseases, we evaluated lead WHRadjBMI variants in association data from GWAS consortia for 22 traits. Seventeen of the 49 variants were associated (<italic>P</italic><5×10<sup>−8</sup>) with at least one of the traits: high-density lipoprotein cholesterol (HDL-C; <italic>n</italic>=7 SNPs), triglycerides (TG; <italic>n=</italic>5), low-density lipoprotein cholesterol (LDL-C; <italic>n=</italic>2), adiponectin adjusted for BMI (<italic>n=</italic>3), fasting insulin adjusted for BMI (<italic>n=</italic>2), T2D (<italic>n=</italic>1), and height (<italic>n=</italic>7) (<xref ref-type="supplementary-material" rid="SD2">Supplementary Tables 8-9</xref>). WHRadjBMI SNPs also showed enrichment for directional consistency among nominally significant (<italic>P</italic><0.05) associations with these traits and also with fasting and 2-hour glucose, diastolic and systolic blood pressure (DBP, SBP), BMI and coronary artery disease (CAD) (<italic>P</italic><sub>binomial</sub><0.05/23=0.0022, <xref ref-type="table" rid="T5">Extended Data Table 2</xref>); these results were generally supported by meta-regression analysis of the regression coefficient-estimates (<xref ref-type="supplementary-material" rid="SD2">Supplementary Table 10</xref>). Furthermore, our WHRadjBMI loci overlap with associations reported in the NHGRI GWAS Catalog (<xref ref-type="table" rid="T2">Table 2</xref>, <xref ref-type="supplementary-material" rid="SD2">Supplementary Table 11</xref>)<sup><xref rid="R16" ref-type="bibr">16</xref></sup>, the strongest of which is the locus near <italic>LEKR1,</italic> which is associated (<italic>P</italic>=2.0×10<sup>−35</sup>) with birthweight<sup><xref rid="R17" ref-type="bibr">17</xref></sup>. Unsupervised hierarchical clustering of the corresponding matrix of association <italic>Z</italic>-scores showed three major clusters characterized by patterns of anthropometric and metabolic traits (<xref ref-type="fig" rid="F6">Extended Data Fig. 4</xref>). These data extend knowledge about genetic links between WHRadjBMI and insulin resistance-related traits; whether this reflects underlying causal relations between WHRadjBMI and these traits, or pleiotropic loci, cannot be inferred from our data.</p></sec><sec id="S5"><title>Potential functional WHRadjBMI variants</title><p id="P14">We next examined variants in LD with the WHRadjBMI lead SNPs (<italic>r</italic><sup>2</sup>>0.7) for predicted effects on protein sequence, copy number, and <italic>cis</italic>-regulatory effects on expression (<xref ref-type="table" rid="T2">Table 2</xref>, <xref ref-type="supplementary-material" rid="SD2">Supplementary Tables 12-15, Supplementary Note</xref>). At 11 of the new loci, lead WHRadjBMI SNPs were in LD with <italic>cis</italic>-expression quantitative trait loci (eQTLs) for transcripts in subcutaneous adipose tissue, omental adipose tissue, liver, or blood cell types (<xref ref-type="table" rid="T2">Table 2</xref>, <xref ref-type="supplementary-material" rid="SD2">Supplementary Table 15</xref>). No additional sex-specific eQTLs were identified, perhaps reflecting limited power (<xref ref-type="supplementary-material" rid="SD2">Supplementary Table 16</xref><bold>)</bold>.</p><p id="P15">At the 11 WHRadjBMI loci harboring eQTLs, we compared the location of the candidate variants to regions of open chromatin (DNase I hypersensitivity and formaldehyde-assisted isolation of regulatory elements [FAIRE]) and histone modification enrichment (H3K4me1, H3K4me2, H3K4me3, H3K27ac, and H3K9ac) in adipose, liver, skeletal muscle, bone, brain, blood, and pancreatic islet tissues or cell lines (<xref ref-type="supplementary-material" rid="SD2">Supplementary Table 17</xref>). At seven of these 11 loci, at least one variant was located in a putative regulatory element in two or more datasets from the same tissue as the eQTL, suggesting that these elements may influence transcriptional activity (<xref ref-type="supplementary-material" rid="SD2">Supplementary Table 18</xref>). For example, at <italic>LEKR1</italic>, five variants in LD with the WHRadjBMI lead SNP are located in a 1.1 kb region with evidence of enhancer activity (H3K4me1 and H3K27ac) in adipose tissue (<xref ref-type="fig" rid="F7">Extended Data Fig. 5a</xref>).</p><p id="P16">We also examined whether any variants overlapped with open chromatin or histone modifications from only one of the tested tissues, possibly reflecting tissue-specific regulatory elements (<xref ref-type="supplementary-material" rid="SD2">Supplementary Table 18</xref>). For example, five variants in a 2.2 kb region, located 77 kb upstream from a <italic>CALCRL</italic> transcription start site, overlapped with peaks in at least five datasets in endothelial cells (<xref ref-type="fig" rid="F7">Extended Data Fig. 5b</xref>), suggesting that one or more of these variants may influence transcriptional activity. <italic>CALCRL</italic>, which is expressed in endothelial cells, is required for lipid absorption in the small intestine, and influences body weight in mice<sup><xref rid="R18" ref-type="bibr">18</xref></sup>. Other variants located in tissue-specific regulatory elements were detected at <italic>NMU</italic> for endothelial cells, at <italic>KLF13</italic> and <italic>MEIS1</italic> for liver, and at <italic>GORAB</italic> and <italic>MSC</italic> for bone (<xref ref-type="supplementary-material" rid="SD2">Supplementary Table 18</xref>).</p></sec><sec id="S6"><title>Biological mechanisms</title><p id="P17">To identify potential functional connections between genes mapping to the 49 WHRadjBMI loci, we used three approaches (<xref ref-type="supplementary-material" rid="SD2">Supplementary Note</xref>). A survey of literature using GRAIL<sup><xref rid="R19" ref-type="bibr">19</xref></sup> identified 15 genes with nominal significance (<italic>P<</italic>0.05) for potential functional connectivity (<xref ref-type="table" rid="T2">Table 2</xref>, <xref ref-type="supplementary-material" rid="SD2">Supplementary Table 19</xref>). The predefined gene set relationships across loci identified using MAGENTA<sup><xref rid="R20" ref-type="bibr">20</xref></sup> highlighted signaling pathways involving vascular endothelial growth factor (VEGF), phosphatase and tensin (PTEN) homolog, the insulin receptor, and peroxisome proliferator-activated receptors (<xref ref-type="supplementary-material" rid="SD2">Supplementary Table 20</xref>). VEGF signaling plays a central, complex role in angiogenesis, insulin resistance, and obesity<sup><xref rid="R21" ref-type="bibr">21</xref></sup>, and PTEN signaling promotes insulin resistance<sup><xref rid="R22" ref-type="bibr">22</xref></sup>. Analyses using DEPICT<sup><xref rid="R23" ref-type="bibr">23</xref></sup> facilitated prioritization of genes at associated loci, analyses of tissue specificity, and enrichment of reconstituted gene sets through integration of association results with expression data, protein-protein interactions, phenotypic data from gene knockout studies in mice, and predefined gene sets. DEPICT identified at least one prioritized gene (false discovery rate (FDR)<5%) at nine loci (<xref ref-type="table" rid="T2">Table 2</xref>, <xref ref-type="supplementary-material" rid="SD2">Supplementary Table 21</xref>) and identified 234 reconstituted gene sets (161 after pruning of overlapping gene sets) enriched for genes at WHRadjBMI loci. Among these we highlight biologically plausible gene sets suggesting roles in body fat regulation (including adiponectin signaling, insulin sensitivity, and regulation of glucose levels), skeletal growth, transcriptional regulation, and development (<xref ref-type="fig" rid="F2">Fig. 2</xref>, <xref ref-type="supplementary-material" rid="SD2">Supplementary Table 22</xref>). We also note gene sets that are specific for abundance or development of metabolically active tissues including adipose, heart, liver, and muscle. Specific genes at the loci were significantly enriched (FDR<5%) for expression in adipocyte-related tissues, including abdominal subcutaneous fat (<xref ref-type="fig" rid="F2">Fig. 2</xref>, <xref ref-type="supplementary-material" rid="SD2">Supplementary Table 23</xref>). Together, these analyses identified processes related to insulin and adipose biology and highlight mesenchymal tissues, especially adipose tissue, as important to WHRadjBMI.</p><p id="P18">We also tested variants at the 49 WHRadjBMI loci for overlap with elements from 60 selected regulatory datasets from the ENCODE<sup><xref rid="R24" ref-type="bibr">24</xref></sup> and Epigenomic RoadMap<sup><xref rid="R25" ref-type="bibr">25</xref></sup> data and found evidence of enrichment in 12 datasets (<italic>P<</italic>0.05/60=8.3×10<sup>−4</sup>, <xref ref-type="table" rid="T6">Extended Data Table 3</xref>). The strongest enrichments were detected for datasets typically attributed to enhancer activity (H3K4me1 and H3K27ac) in adipose, muscle, endothelial cells, and bone, suggesting that variants may regulate transcription in these tissues. These analyses point to mechanisms linking WHRadjBMI loci to regulation of gene expression in tissues highly relevant for adipocyte metabolism and insulin resistance.</p><p id="P19">We also reviewed functions of candidate genes located near new and previously established WHRadjBMI loci<sup><xref rid="R7" ref-type="bibr">7</xref>,<xref rid="R8" ref-type="bibr">8</xref></sup>, identifying genes involved in adipogenesis, angiogenesis, and transcriptional regulation (<xref ref-type="table" rid="T2">Table 2</xref><bold>,</bold> literature review in the <xref ref-type="supplementary-material" rid="SD2">Supplementary Note</xref>). Adipogenesis candidate genes include <italic>CEBPA, PPARG, BMP2, HOXC/miR196, SPRY1, TBX15,</italic> and <italic>PEMT</italic>. Of these, <italic>CEBPA</italic> and <italic>PPARG</italic> are essential for white adipose tissue differentiation<sup><xref rid="R26" ref-type="bibr">26</xref></sup>, <italic>BMP2</italic> induces differentiation of mesenchymal stem cells toward adipogenesis or osteogenesis<sup><xref rid="R27" ref-type="bibr">27</xref></sup>, and <italic>HOXC8</italic> is a repressor of brown adipogenesis in mice that is regulated by miR-196a<sup><xref rid="R28" ref-type="bibr">28</xref></sup>, also located within the <italic>HOXC</italic> region (<xref ref-type="fig" rid="F1">Fig. 1</xref>). Angiogenesis genes may influence expansion and loss of adipose tissue<sup><xref rid="R29" ref-type="bibr">29</xref></sup>; they include <italic>VEGFA</italic>, <italic>VEGFB</italic>, <italic>RSPO3</italic>, <italic>STAB1</italic>, <italic>WARS2</italic>, <italic>PLXND1</italic>, <italic>MEIS1</italic>, <italic>FGF2</italic>, <italic>SMAD6</italic>, and <italic>CALCRL</italic>. <italic>VEGFB</italic> is involved in endothelial targeting of lipids to peripheral tissues<sup><xref rid="R30" ref-type="bibr">30</xref></sup>, and <italic>PLXND1</italic> limits blood vessel branching, antagonizes VEGF, and affects adipose inflammation<sup><xref rid="R31" ref-type="bibr">31</xref>,<xref rid="R32" ref-type="bibr">32</xref></sup>. Transcriptional regulators at WHRadjBMI loci include <italic>CEBPA</italic>, <italic>PPARG</italic>, <italic>MSC</italic>, <italic>SMAD6</italic>, <italic>HOXA</italic>, <italic>HOXC</italic>, <italic>ZBTB7B</italic>, <italic>JUND</italic>, <italic>KLF13</italic>, <italic>MEIS1</italic>, <italic>RFX7</italic>, <italic>NKX2-6</italic>, and <italic>HMGA1</italic>. Other candidate genes include <italic>NMU, FGFR4</italic>, and <italic>HMGA1</italic>, for which mice deficient for the corresponding genes exhibit obesity, glucose intolerance, and/or insulin resistance<sup><xref rid="R33" ref-type="bibr">33</xref>-<xref rid="R35" ref-type="bibr">35</xref></sup>.</p></sec><sec id="S7"><title>Five additional central obesity traits</title><p id="P20">To determine whether the WHRadjBMI variants exert their effects primarily through WC or HIP and to identify loci that are not reported for WHRadjBMI, BMI, or height<sup><xref rid="R36" ref-type="bibr">36</xref>,<xref rid="R37" ref-type="bibr">37</xref></sup>, we performed association analyses for five additional traits: WCadjBMI, HIPadjBMI, WHR, WC, and HIP. Based on phenotypic data alone, WC and HIP are highly correlated with BMI (<italic>r</italic>=0.59<italic><bold>-</bold></italic>0.92), and WHR is highly correlated with WHRadjBMI (<italic>r</italic>=0.82<italic><bold>-</bold></italic>0.95), while WCadjBMI and HIPadjBMI are moderately correlated with height (<italic>r</italic>=0.24<italic><bold>-</bold></italic>0.63, <xref ref-type="supplementary-material" rid="SD2">Supplementary Table 24</xref>). In contrast to WHRadjBMI, which has almost no genetic correlation (see Methods) with height (<italic>r<sub>G</sub></italic><0.04, <xref ref-type="fig" rid="F4">Extended Data Fig. 2c</xref>), WCadjBMI (<italic>r<sub>G</sub></italic>=0.42) and HIPadjBMI (<italic>r<sub>G</sub></italic><sub>=</sub>0.82) have moderate genetic correlations with height. These data suggest that some, but not all, WCadjBMI and HIPadjBMI loci would be associated with height.</p><p id="P21">Across all meta-analyses, we identified an additional 19 loci associated with one of the five traits (<italic>P<</italic>5×10<sup>−8</sup>), nine of which showed significantly larger effects (<italic>P</italic><sub>difference</sub><0.05/19=0.003) in one sex than in the other (<xref ref-type="table" rid="T3">Table 3</xref>, <xref ref-type="supplementary-material" rid="SD2">Supplementary Figs. 1-4, Supplementary Table 25</xref>). Three of four new loci with larger effects in women were associated with HIPadjBMI and three of five new loci with larger effects in men were associated with WCadjBMI. Most of the 19 loci showed some evidence of association with WHRadjBMI in sex-combined or sex-specific analyses, but four loci showed no association (<italic>P</italic>>0.01) with WHRadjBMI, BMI, or height (<xref ref-type="supplementary-material" rid="SD2">Supplementary Tables 8, 26</xref>).</p><p id="P22">We next asked whether the genes and pathways influencing these five traits are shared with WHRadjBMI or are distinct. Candidate genes were identified based on association with other traits, eQTLs, GRAIL, and literature review (<xref ref-type="table" rid="T7">Extended Data Table 4</xref>, <xref ref-type="supplementary-material" rid="SD2">Supplementary Tables 8, 11-13, 15-16, 19</xref>). Candidate variants identified based on LD (<italic>r</italic><sup>2</sup>>0.7) included coding variants in <italic>NTAN1</italic> and <italic>HMGXB4</italic>, and six loci showed significant eQTLs in subcutaneous adipose tissue. Based on the literature, several candidate genes are involved in adipogenesis and insulin resistance. For example, delayed induction of preadipocyte transcription factor <italic>ZNF423</italic> in fibroblasts results in delayed adipogenesis<sup><xref rid="R38" ref-type="bibr">38</xref></sup>, and <italic>NLRP3</italic> is part of inflammasome and pro-inflammatory T-cell populations in adipose tissue that contribute to inflammation and insulin resistance<sup><xref rid="R39" ref-type="bibr">39</xref></sup>. GRAIL analyses identified connections that partially overlap with those identified for WHRadjBMI (<xref ref-type="supplementary-material" rid="SD2">Supplementary Table 19</xref>). Taken together, the additional loci appear to function in processes similar to the WHRadjBMI loci. The identification of loci that are more strongly associated with WCadjBMI or HIPadjBMI than the other anthropometric traits suggests that the additional traits characterize aspects of central obesity and fat distribution that are not captured by WHRadjBMI or BMI alone.</p></sec></sec><sec sec-type="discussion" id="S8"><title>DISCUSSION</title><p id="P23">These meta-analyses of GWAS and Metabochip data in up to 224,459 individuals identified additional loci associated with waist and hip circumference measures and help elucidate the role of common genetic variation in body fat distribution that is distinct from BMI and height. Our results emphasize the strong sexual dimorphism in the genetic regulation of fat distribution traits, a characteristic not observed for overall obesity as assessed by BMI<sup><xref rid="R36" ref-type="bibr">36</xref></sup>. Differences in body fat distribution between the sexes emerge in childhood, become more apparent during puberty<sup><xref rid="R40" ref-type="bibr">40</xref></sup>, and change with menopause, generally attributed to the influence of sex hormones<sup><xref rid="R41" ref-type="bibr">41</xref>,<xref rid="R42" ref-type="bibr">42</xref></sup>. At loci with stronger effects in one sex than the other, these hormones may interact with transcription factors to regulate gene activity.</p><p id="P24">Annotation of the loci emphasized the role for mesenchymally-derived tissues, especially adipose tissue, in fat distribution and central obesity. The development and regulation of adipose tissue deposition is closely associated with angiogenesis<sup><xref rid="R29" ref-type="bibr">29</xref></sup>, a process highlighted by candidate genes at several WHRadjBMI loci. These tissues are implicated in insulin resistance, consistent with the enrichment of shared GWAS signals with lipids, T2D, and glycemic traits. The identification of skeletal growth processes suggests that the underlying genes affect early development and/or differentiation of adipocytes from mesenchymal stem cells. In contrast, BMI has a significant neuronal component, involving processes such as appetite regulation<sup><xref rid="R36" ref-type="bibr">36</xref></sup>. Our results provide a foundation for future biological research in the regulation of body fat distribution and its connections with cardiometabolic traits, and offer potential target mechanisms for interventions in the risks associated with abdominal fat accumulation.</p></sec><sec sec-type="methods" specific-use="web-only" id="S9"><title>METHODS</title><sec id="S10"><title>Study overview</title><p id="P25">Our study included 224,459 individuals of European, East Asian, South Asian, and African American ancestry. The European ancestry arm included 142,762 individuals from 57 cohorts genotyped with genome-wide SNP arrays and 67,326 individuals from 44 cohorts genotyped with the Metabochip<sup><xref rid="R11" ref-type="bibr">11</xref></sup> (<xref ref-type="fig" rid="F3">Extended Data Fig. 1</xref>, <xref ref-type="supplementary-material" rid="SD2">Supplementary Table 1</xref>). The non-European ancestry arm comprised ~1,700 individuals from one cohort of East Asian ancestry, ~3,400 individuals from one cohort of South Asian ancestry, and ~9,200 individuals from six cohorts of African American ancestry, all genotyped with the Metabochip. There was no overlap between individuals genotyped with genome-wide SNP arrays and Metabochip. For each study, local institutional committees approved study protocols and confirmed that informed consent was obtained.</p></sec><sec id="S11"><title>Traits</title><p id="P26">Our primary trait was WHRadjBMI, the ratio of waist and hip circumferences adjusted for age, age<sup><xref rid="R2" ref-type="bibr">2</xref></sup>, study-specific covariates if necessary, and BMI. For each cohort, residuals were calculated for men and women separately and then transformed by the inverse standard normal function. Cohorts with related men and women provided inverse standard normal transformed sex-combined residuals. For each cohort, the same transformations were applied to other traits: (i) WHR without adjustment for BMI (WHR); (ii) waist circumference with (WCadjBMI) and without (WC) adjustment for BMI; and (iii) hip circumference with (HIPadjBMI) and without (HIP) adjustment for BMI.</p></sec><sec id="S12"><title>European ancestry meta-analysis for genome-wide SNP array data</title><p id="P27">Sample and SNP quality control (QC) were undertaken within each cohort (<xref ref-type="supplementary-material" rid="SD2">Supplementary Table 3</xref>)<sup><xref rid="R44" ref-type="bibr">44</xref></sup>. The GWAS scaffold in each cohort was imputed up to CEU haplotypes from HapMap resulting in ~2.5 million SNPs. Each directly typed and imputed SNP passing QC was tested for association with each trait under an additive model in a linear regression framework (<xref ref-type="supplementary-material" rid="SD2">Supplementary Table 3</xref>). SNP positions are reported based on NCBI Build 36. For each cohort, sex-specific association summary statistics were corrected for residual population structure using the genomic control inflation factor<sup><xref rid="R45" ref-type="bibr">45</xref></sup> (median λ<sub>GC</sub>=1.01, range=0.99 – 1.08). SNPs were removed prior to meta-analysis if they had a minor allele count ≤ 3, deviation from Hardy-Weinberg equilibrium exact <italic>P</italic><10<sup>−6</sup>, directly genotyped SNP call rate<95%, or low imputation quality (below 0.3 for MACH, 0.4 for IMPUTE, and 0.8 for PLINK). Association summary statistics for each trait were combined via inverse-variance weighted fixed-effects meta-analysis and corrected for a second round of genomic control to account for structure between cohorts (<xref ref-type="fig" rid="F3">Extended Data Fig. 1</xref>, <xref ref-type="supplementary-material" rid="SD2">Supplementary Fig. 1</xref>).</p></sec><sec id="S13"><title>European ancestry meta-analysis for Metabochip data</title><p id="P28">Sample and SNP QC analyses were undertaken in each cohort (<xref ref-type="supplementary-material" rid="SD2">Supplementary Table 3</xref>). Each SNP passing QC was tested for association with each trait under an additive model using linear regression. The Metabochip array<sup><xref rid="R11" ref-type="bibr">11</xref></sup> is enriched, by design, for loci associated with anthropometric and cardiometabolic traits, thus, we based our correction on 4,425 SNPs selected for inclusion based on associations with QT-interval that were not expected to be associated with anthropometric traits (>500 kb from variants on Metabochip<sup><xref rid="R46" ref-type="bibr">46</xref></sup> for these traits). These study-specific inflation factors had a median λ<sub>GC</sub>=1.01(range 0.93–1.11), with only one study exceeding 1.10. After removing SNPs for QC as described in the previous section, association summary statistics were combined via inverse-variance weighted fixed-effects meta-analysis and corrected for a second round of genomic control on the basis of QT-interval SNPs to account for structure between cohorts.</p></sec><sec id="S14"><title>European ancestry meta-analyses</title><p id="P29">Association summary statistics from the two parts of the European ancestry arm were combined via inverse-variance weighted fixed-effects meta-analysis using METAL<sup><xref rid="R47" ref-type="bibr">47</xref></sup> with no further genomic control correction. Results were reported for SNPs with a sex-combined sample size≥50,000. The meta-analyses were repeated for men and women separately for each trait. Analyses were corrected for population structure within each sex. The meta-analysis of WHRadjBMI in men included up to 93,480 individuals, and in women up to 116,742 individuals.</p></sec><sec id="S15"><title>Meta-analyses of studies of all ancestries</title><p id="P30">Sample and SNP QC, tests of association, genomic control correction (median λ<sub>GC</sub>=1.01, range=0.90–1.17, with only one study exceeding 1.10), and meta-analyses were performed as described above. Association summary statistics from the European and non-European ancestry meta-analyses were combined via inverse-variance weighted fixed-effects meta-analysis without further genomic control correction.</p></sec><sec id="S16"><title>Heterogeneity</title><p id="P31">For each lead SNP, we tested for sex differences based on the sex-specific beta estimates and standard errors, while accounting for potential correlation between estimates as previously used in Randall et al<sup><xref rid="R10" ref-type="bibr">10</xref></sup>. Similarly, we tested for potential differences in effects between European and non-European samples, comparing the effects from GWAS+Metabochip data for Europeans and Metabochip data for non-Europeans, and we tested for differences between population-based studies and samples ascertained on diabetes status, and cardiovascular disease, or both. In assessing effects of ascertainment overall, we compared effects in seven subsets of our study sample using population-based studies (i.e., those not ascertained on any phenotype) as the referent population: 1) all studies ascertained on any phenotype, 2) T2D cases, 3) T2D controls, 4) T2D cases+controls, 5) CAD cases, 6) CAD controls, and 7) CAD cases+controls. We evaluated significance for heterogeneity tests within each comparison using a Bonferroni-corrected p-value of 0.05/49=0.05/49=1.02×10<sup>−3</sup> as well as an FDR threshold<sup><xref rid="R48" ref-type="bibr">48</xref></sup> of <5% (<xref ref-type="supplementary-material" rid="SD2">Supplementary Table 28</xref>). Between-study heterogeneity in all meta-analyses was assessed using <italic>I</italic><sup>2</sup> statistics<sup><xref rid="R49" ref-type="bibr">49</xref></sup>.</p></sec><sec id="S17"><title>Heritability and genetic and phenotypic correlations of waist traits</title><p id="P32">We calculated the heritability and genetic correlations of several central obesity traits using variance component models<sup><xref rid="R50" ref-type="bibr">50</xref>,<xref rid="R51" ref-type="bibr">51</xref></sup> in the Framingham Heart Study (FHS) and TWINGENE study. In this approach, the phenotypic variance is decomposed into additive genetic, non-additive genetic, and environmental sources of variation (including model error), and for sets of traits, the covariances between traits. We report narrow sense heritability (<italic>h</italic><sup>2</sup>), the ratio of the additive genetic variance to the total phenotypic variance. Sex-specific inverse normal trait residuals, adjusted for age (and cohort in FHS), were used to estimate heritability separately in men and women, using variance components analysis in SOLARv.4.2.7<sup><xref rid="R52" ref-type="bibr">52</xref></sup> (FHS) or M×1.703<sup><xref rid="R53" ref-type="bibr">53</xref></sup> (TWINGENE). Additionally, the sex-specific residuals were used to conduct bivariate quantitative variance component genetic analyses that calculate genetic and environmental correlations between traits. The genetic correlations obtained are estimates of the additive effects of shared genes, and a genetic correlation significantly different from zero suggests a direct influence of the same genes on more than one trait. Similarly, significant environmental correlations suggest shared environmental effects.</p><p id="P33">We estimated sex-stratified correlations between all waist traits, as well as BMI, height, and weight in TWINGENE, FHS, KORA, and EGCUT. In TWINGENE and FHS, age-adjusted Pearson correlations were used; in EGCUT and KORA, correlations were adjusted for age and age<sup><xref rid="R2" ref-type="bibr">2</xref></sup>.</p></sec><sec id="S18"><title>European ancestry approximate conditional analyses</title><p id="P34">To evaluate the evidence for multiple association signals within identified loci, we performed approximate conditional analyses of sex-combined, women-specific, and men-specific data as implemented in the GCTA software<sup><xref rid="R14" ref-type="bibr">14</xref>,<xref rid="R54" ref-type="bibr">54</xref></sup>. This approach makes use of association summary statistics from the combined European ancestry meta-analysis and a reference dataset of individual-level genotype data to estimate LD between variants and hence also the approximate correlation between allelic effect estimates in a joint association model.</p><p id="P35">To evaluate robustness of the GCTA results, we performed analyses using two reference datasets: Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) consisting of 949 individuals from Uppsala County, Sweden with both GWAS and Metabochip genotype data; and Atherosclerosis Risk in Communities (ARIC) consisting of 6,654 individuals of European descent from four communities in the USA with GWAS data. Both GWAS datasets were imputed using data from Phase II of the International HapMap Project<sup><xref rid="R55" ref-type="bibr">55</xref></sup>. Results shown use the PIVUS reference dataset because Metabochip genotypes are available (see a comparison in the <xref ref-type="supplementary-material" rid="SD2">Supplementary Note</xref><bold>)</bold>. Assuming that the LD correlations between SNPs more than 10 Mb away are zero, and using each reference dataset in turn, we performed a genome-wide stepwise selection procedure to select associated SNPs one-by-one at a <italic>P</italic> value<5×10<sup>−8</sup>. For each locus at which multiple association signals were observed in the sex-combined, women-, and/or men-specific data, the SNPs selected by GCTA as independently associated with WHRadjBMI in any of the three meta-analyses are reported, with the SNP identified in the sex-combined analysis taken by default when proxies are identified in the women- and/or men-specific analyses. For SNPs not selected by a particular joint conditional analysis, but identified by either of the other two analyses, summary statistics were calculated for association analysis of the SNP conditioned on the GCTA-selected SNP(s).</p></sec><sec id="S19"><title>Genetic risk score</title><p id="P36">We calculated a genetic risk score for each individual in the population-based KORA study (1,670 men and 1,750 women) using the 49 identified variants, weighted by the allelic effect from the European ancestry meta-analyses of WHRadjBMI. Sex-combined scores were computed on the basis of the sex-combined meta-analysis. Sex-stratified scores were calculated on the basis of men- and women-specific meta-analyses, where SNPs not achieving nominal significance in the respective sex (<italic>P</italic>≥0.05) were excluded. For each individual, the sex-combined and sex-stratified risk scores were rounded to the nearest integer for plotting. Risk scores were then tested for association with WHRadjBMI using linear regression.</p></sec><sec id="S20"><title>Explained variance</title><p id="P37">We calculated the variance explained by a single SNP as:
<disp-formula id="FD1"><mml:math display="block" id="M1" overflow="scroll"><mml:mrow><mml:mn>2</mml:mn><mml:mi>•</mml:mi><mml:mi>M</mml:mi><mml:mi>A</mml:mi><mml:mi>F</mml:mi><mml:mi>•</mml:mi><mml:mo>(</mml:mo><mml:mn>1</mml:mn><mml:mo>−</mml:mo><mml:mi>M</mml:mi><mml:mi>A</mml:mi><mml:mi>F</mml:mi><mml:mo>)</mml:mo><mml:mi>•</mml:mi><mml:mfrac><mml:mrow><mml:msup><mml:mi>β</mml:mi><mml:mn>2</mml:mn></mml:msup></mml:mrow><mml:mrow><mml:mi>V</mml:mi><mml:mi>a</mml:mi><mml:mi>r</mml:mi><mml:mo>(</mml:mo><mml:mi>Y</mml:mi><mml:mo>)</mml:mo></mml:mrow></mml:mfrac></mml:mrow></mml:math></disp-formula>where MAF is the minor allele frequency, <italic>β</italic> is the SNP effect estimate computed by meta-analysis, and Var(Y) is the variance of the phenotype Y as it went into the study-specific association testing. To derive the total variance explained by a set of independent SNPs, we computed the sum of single-SNP explained variances under the assumption of independent contributions.</p><p id="P38">To estimate the polygenic variance explained by all HapMap SNPs, we used the all-SNP estimation approach implemented in GCTA and analysed individuals in the ARIC and TwinGene cohorts, including the first 20 principal components as fixed covariates. After removing one of each pair of individuals with estimated genetic relatedness>0.025, 11,898 unrelated individuals with WHRadjBMI were available.</p></sec><sec id="S21"><title>Fine-mapping analyses</title><p id="P39">We considered each identified locus, defined as 500 kb upstream and downstream of the lead SNP, and computed 95% credible intervals using a Bayesian approach. On the basis of association summary statistics from the European ancestry, non-European ancestry, or all ancestries sex-combined meta-analyses, we calculated an approximate Bayes’ factor<sup><xref rid="R56" ref-type="bibr">56</xref></sup> in favor of association, given by:
<disp-formula id="FD2"><mml:math display="block" id="M2" overflow="scroll"><mml:mrow><mml:mi>B</mml:mi><mml:msub><mml:mi>F</mml:mi><mml:mi>j</mml:mi></mml:msub><mml:mo>=</mml:mo><mml:mfrac><mml:msqrt><mml:mrow><mml:mn>1</mml:mn><mml:mo>−</mml:mo><mml:msub><mml:mi>R</mml:mi><mml:mi>j</mml:mi></mml:msub></mml:mrow></mml:msqrt><mml:mrow><mml:mi>exp</mml:mi><mml:mo>(</mml:mo><mml:mo>−</mml:mo><mml:mfrac><mml:mrow><mml:msub><mml:mi>R</mml:mi><mml:mi>j</mml:mi></mml:msub><mml:msubsup><mml:mi>β</mml:mi><mml:mi>j</mml:mi><mml:mn>2</mml:mn></mml:msubsup></mml:mrow><mml:mrow><mml:mn>2</mml:mn><mml:msubsup><mml:mi>σ</mml:mi><mml:mi>j</mml:mi><mml:mn>2</mml:mn></mml:msubsup></mml:mrow></mml:mfrac><mml:mo>)</mml:mo></mml:mrow></mml:mfrac></mml:mrow></mml:math></disp-formula>where <italic>β<sub>j</sub></italic> is the allelic effect of the <italic>j</italic><sup>th</sup> SNP, with corresponding standard error <italic>σ<sub>j</sub></italic>, and <inline-formula><mml:math display="inline" id="M3" overflow="scroll"><mml:mrow><mml:msub><mml:mi>R</mml:mi><mml:mi>j</mml:mi></mml:msub><mml:mo>=</mml:mo><mml:mn>0.04</mml:mn><mml:mo>∕</mml:mo><mml:mo>(</mml:mo><mml:msubsup><mml:mi>σ</mml:mi><mml:mi>j</mml:mi><mml:mn>2</mml:mn></mml:msubsup><mml:mo>+</mml:mo><mml:mn>0.04</mml:mn><mml:mo>)</mml:mo></mml:mrow></mml:math></inline-formula>, which incorporates a N(0,0.2<sup>2</sup>) prior for <italic>β<sub>j</sub></italic>. This prior gives high probability to small effect sizes, and only small probability to large effect sizes. We then calculated the posterior probability that the <italic>j</italic>th SNP is causal by:
<disp-formula id="FD3"><mml:math display="block" id="M4" overflow="scroll"><mml:mrow><mml:msub><mml:mi>φ</mml:mi><mml:mi>j</mml:mi></mml:msub><mml:mo>=</mml:mo><mml:mfrac><mml:mrow><mml:mi>B</mml:mi><mml:msub><mml:mi>F</mml:mi><mml:mi>j</mml:mi></mml:msub></mml:mrow><mml:mrow><mml:msub><mml:mi>Σ</mml:mi><mml:mi>k</mml:mi></mml:msub><mml:mi>B</mml:mi><mml:msub><mml:mi>F</mml:mi><mml:mi>k</mml:mi></mml:msub></mml:mrow></mml:mfrac></mml:mrow></mml:math></disp-formula>where the summation in the denominator is over all SNPs passing QC across the locus. We compared the meta-analysis results and credible sets of SNPs likely to contain the causal variant as described<sup><xref rid="R57" ref-type="bibr">57</xref></sup>. Assuming a single causal variant at each locus, a 95% credible set of variants was then constructed by: (i) ranking all SNPs according to their Bayes’ factor; and (ii) combining ranked SNPs until their cumulative posterior probability exceeded 0.95. For each locus, we calculated the number of SNPs contained within the 95% credible sets, and the length of the genomic interval covered by these SNPs.</p></sec><sec id="S22"><title>Comparison of loci across traits</title><p id="P40">To determine whether the identified loci were also associated with any of 22 cardio-metabolic traits, we obtained association data from meta-analysis consortia DIAGRAM (T2D)<sup><xref rid="R58" ref-type="bibr">58</xref></sup>, CARDIoGRAM-C4D (CAD)<sup><xref rid="R59" ref-type="bibr">59</xref></sup>, ICBP (SBP, DBP)<sup><xref rid="R60" ref-type="bibr">60</xref></sup>, GIANT (BMI, height)<sup><xref rid="R36" ref-type="bibr">36</xref>,<xref rid="R37" ref-type="bibr">37</xref></sup>, GLGC (HDL, LDL, and TG)<sup><xref rid="R61" ref-type="bibr">61</xref></sup>, MAGIC (fasting glucose, fasting insulin, fasting insulin adjusted for BMI, and two-hour glucose)<sup><xref rid="R62" ref-type="bibr">62</xref>-<xref rid="R64" ref-type="bibr">64</xref></sup>, ADIPOGen (BMI-adjusted adiponectin)<sup><xref rid="R65" ref-type="bibr">65</xref></sup>, CKDgen (urine albumin-to-creatinine ratio (UACR), estimated glomerular filtration rate (eGFR), and overall CKD)<sup><xref rid="R66" ref-type="bibr">66</xref>,<xref rid="R67" ref-type="bibr">67</xref></sup>, ReproGen (age at menarche, age at menopause)<sup><xref rid="R68" ref-type="bibr">68</xref>,<xref rid="R69" ref-type="bibr">69</xref></sup>, and GEFOS (bone mineral density)<sup><xref rid="R70" ref-type="bibr">70</xref></sup>; others provided association data for IgA nephropathy<sup><xref rid="R71" ref-type="bibr">71</xref></sup> (also Kiryluk K, Choi M, Lifton RP, Gharavi AG, unpublished data) and for endometriosis (stage B cases only)<sup><xref rid="R72" ref-type="bibr">72</xref></sup>. Proxies (<italic>r</italic><sup>2</sup>>0.80 in CEU) were used when an index SNP was unavailable.</p><p id="P41">We also searched the National Human Genome Research Institute (NHGRI) GWAS Catalog for previous SNP-trait associations near our lead SNPs<sup><xref rid="R73" ref-type="bibr">73</xref></sup>. We supplemented the catalog with additional genome-wide significant SNP-trait associations from the literature<sup><xref rid="R13" ref-type="bibr">13</xref>,<xref rid="R70" ref-type="bibr">70</xref>,<xref rid="R74" ref-type="bibr">74</xref>-<xref rid="R80" ref-type="bibr">80</xref></sup>. We used PLINK to identify SNPs within 500 kb of lead SNPs using 1000 Genomes Project Pilot I genotype data and LD (<italic>r</italic><sup>2</sup>) values from CEU<sup><xref rid="R81" ref-type="bibr">81</xref>,<xref rid="R82" ref-type="bibr">82</xref></sup>; for rs7759742, HapMap release 22 CEU data<sup><xref rid="R81" ref-type="bibr">81</xref>,<xref rid="R83" ref-type="bibr">83</xref></sup> were used. All SNPs within the specified regions were compared with the NHGRI GWAS Catalog<sup><xref rid="R16" ref-type="bibr">16</xref></sup>.</p><sec id="S23"><title>Enrichment of concordant cross-trait associations and effects</title><p id="P42">To evaluate whether the alleles associated with increased WHRadjBMI at the 49 identified SNPs convey effects for any of the 22 cardiometabolic traits, we conducted meta-regression analyses of the beta-estimates on these metabolic outcomes from other consortia with the beta-estimates for WHRadjBMI in our data<sup><xref rid="R65" ref-type="bibr">65</xref></sup>.</p><p id="P43">Based on the association data across traits, we generated a matrix of <italic>Z</italic>-scores by dividing the association betas for each of the 49 WHRadjBMI SNPs for each of 22 traits by their respective standard errors. The traits did not include WHRadjBMI or nephropathy in Chinese subjects, but did include HIPadjBMI and WCadjBMI. Each <italic>Z</italic>-score was made positive if the original trait-increasing allele also increased the look-up trait and negative if not. Missing associations with were assigned a value of zero. We performed unsupervised hierarchical clustering of the <italic>Z</italic> score matrix in R using the default settings of the “heatplot” function from the made4 library (version 1.20.0), agglomerating clusters using average linkage and Pearson correlation metric distance. The rows and columns of matrix values were each automatically scaled to range from 3 to −3. Confidence in the hierarchical clustering was assessed by bootstrap analysis (10,000 resamplings) using the R package “pvclust”<sup><xref rid="R84" ref-type="bibr">84</xref></sup>.</p></sec><sec id="S24"><title>Identification of candidate functional variants</title><p id="P44">The 1000 Genomes CEU pilot data were queried for SNPs within 500 kb and in LD (<italic>r</italic><sup>2</sup>>0.7, an arbitrary threshold) with any index SNP. All identified variants were then annotated based on RefSeq transcripts using Annovar to identify potential nonsynonymous variants near identified association signals. The distance between each variant and the nearest transcription start site were calculated using gene annotations from GENCODE (v.12).</p><p id="P45">To investigate whether SNPs in LD with index SNPs are also in LD with common copy number variants (CNVs), we extracted waist trait association results for a list of SNP proxies that are in high LD (r<sup>2</sup>>0.8, CEU) with CNVs in European populations as described previously<sup><xref rid="R7" ref-type="bibr">7</xref></sup>. Altogether 6,200 CNV-tagging SNPs were used, which are estimated collectively to capture>40% of CNVs>1 kb in size.</p></sec><sec id="S25"><title>Expression quantitative trait loci (eQTLs)</title><p id="P46">We examined our lead SNPs in eQTL datasets from several sources (<xref ref-type="supplementary-material" rid="SD2">Supplementary Note</xref>) for <italic>cis</italic> effects significant at <italic>P<</italic>10<sup>−5</sup>. We then checked if the trait-associated SNP also had the strongest association with the expression level of its corresponding transcript. If not, we identified a nearby SNP that had a stronger association with expression (peak transcript SNP) of that transcript. To check whether effects of the peak transcript SNP and waist trait-associated SNP overlapped, we conducted conditional analyses to estimate associations between the waist-associated SNP and transcript level when the peak transcript-associated SNP was also included in the model, and vice versa. If the association for the expression-associated SNP was not significant (<italic>P</italic>>0.05) when conditioned on the waist-associated SNP, we concluded that the waist-associated SNP is likely to explain a substantial proportion of the variance in gene transcript levels in the region. For SNPs that passed these criteria in either women or men eQTL datasets from deCODE, we investigated sex heterogeneity in gene transcript levels for whole blood (312 men, 435 women) and subcutaneous adipose tissue (252 men, 351 women) based on the sex-specific beta estimates and standard errors, while accounting for potential correlation between the sex-specific associations<sup><xref rid="R8" ref-type="bibr">8</xref></sup>.</p></sec><sec id="S26"><title>Epigenomic regulatory element overlap with individual variants</title><p id="P47">We examined overlap of regulatory elements with the 68 trait-associated variants and variants in LD with them (<italic>r</italic><sup>2</sup>>0.7, 1000 Genomes Phase 1 version 2 EUR<sup><xref rid="R85" ref-type="bibr">85</xref></sup>), totaling 1,547 variants. We obtained regulatory element data sets from the ENCODE Consortium<sup><xref rid="R24" ref-type="bibr">24</xref></sup> and Roadmap Epigenomics Project<sup><xref rid="R25" ref-type="bibr">25</xref></sup> corresponding to eight tissues selected based on a current understanding of WHRadjBMI pathways. The 226 regulatory element datasets included experimentally identified regions of open chromatin (DNase-seq, FAIRE-seq), histone modification (H3K4me1, H3K27ac, H3K4me3, H3K9ac, and H3K4me2), and transcription factor binding (<xref ref-type="supplementary-material" rid="SD2">Supplementary Table 17</xref>). When available, we downloaded data processed during the ENCODE Integrative Analysis<sup><xref rid="R24" ref-type="bibr">24</xref></sup>. We processed Roadmap Epigenomics sequencing data with multiple biological replicates using MACS2<sup><xref rid="R86" ref-type="bibr">86</xref></sup> and the same Irreproducible Discovery Rate pipeline used in the ENCODE Integrative Analysis. Roadmap Epigenomics data with only a single replicate was processed using MACS2 alone.</p></sec><sec id="S27"><title>Global enrichment of WHRadjBMI-associated loci in epigenomic datasets</title><p id="P48">We performed permutation-based tests in a subset of 60 open chromatin (DNase-seq) and histone modification (H3K27ac, H3K4me1, H3K4me3, H3K9ac) datasets to identify global enrichment of the WHRadjBMI-associated loci. We matched the index SNP at each locus with 500 variants having no evidence of association (<italic>P></italic>0.5, ~1.2 million total variants) with a similar distance to the nearest gene (±11,655 bp), number of variants in LD (±8 variants), and minor allele frequency. Using these pools, we created 10,000 sets of control variants for each of the 49 loci and identified variants in LD (<italic>r<sup>2</sup></italic>>0.7) and within 1 Mb. For each SNP set, we calculated the number of loci with at least one variant located in a regulatory region under the assumption that one regulatory variant is responsible for each association signal. We initially calculated an enrichment <italic>P</italic> value by finding the proportion of control sets for which as many or more loci overlap a regulatory element than the set of associated loci. For increased <italic>P</italic> value accuracy, we estimated the <italic>P</italic> value assuming a sum of binomial distributions to represent the number of index SNPs or their LD proxies that overlap a regulatory dataset compared to the 500 matched control sets.</p></sec><sec id="S28"><title>GRAIL</title><p id="P49">Gene Relationships Among Implicated Loci (GRAIL)<sup><xref rid="R19" ref-type="bibr">19</xref></sup> is a text-mining algorithm that evaluates the degree of relatedness among genes within trait regions. Using PubMed abstracts, a subset of genes enriched for relatedness and a set of keywords that suggest putative pathways are identified. To avoid potential bias from papers investigating candidate genes stimulated by GWAS, we restricted our search to abstracts published prior to 2006. We tested for enrichment of connectivity in the independent SNPs that were significant in our study at <italic>P</italic><10<sup>−5</sup>.</p></sec><sec id="S29"><title>MAGENTA</title><p id="P50">To investigate if pathways including predefined sets of genes were enriched in the lower part of the gene <italic>P</italic> value distribution for WHRadjBMI, we performed a pathway analysis using Magenta 2.4<sup><xref rid="R20" ref-type="bibr">20</xref></sup> and SNPs present in both the Metabochip and GWAS meta-analyses. SNPs were assigned to a gene if within 110 kb upstream or 40 kb downstream of the transcript’s boundaries. The most significant SNP <italic>P</italic> value within this interval was adjusted for putative confounders (gene size, number of SNPs in a gene, LD pattern) using stepwise linear regression, creating a gene association score. If the same SNP was assigned to multiple genes, only the gene with the lowest gene score was kept. The <italic>HLA</italic> region was removed from further analyses due to its high LD structure and gene density. Each gene was then assigned pathway terms using Gene Ontology (GO), PANTHER, Ingenuity and Kyoto Encyclopedia of Genes and Genomes (KEGG)<sup><xref rid="R87" ref-type="bibr">87</xref>-<xref rid="R90" ref-type="bibr">90</xref></sup>. Finally, the genes were ranked based on their gene association score, and a modified gene-set enrichment analysis (GSEA) using MAGENTA was performed. This analysis tested for enrichment of gene association score ranks above a given rank cutoff (including 5% of all genes) in a gene-set belonging to a predefined pathway term, compared to multiple, equally sized gene-sets that were randomly sampled from all genes in the genome. 10,000-1,000,000 gene-set permutations were performed.</p></sec><sec id="S30"><title>Data-driven Expression-Prioritized Integration for Complex Traits (DEPICT)</title><p id="P51">This method is described in detail elsewhere<sup><xref rid="R23" ref-type="bibr">23</xref>,<xref rid="R36" ref-type="bibr">36</xref></sup>. Briefly, DEPICT uses gene expression data derived from a panel of 77,840 expression arrays<sup><xref rid="R91" ref-type="bibr">91</xref></sup>, 5,984 molecular pathways (based on 169,810 high-confidence experimentally-derived protein-protein interactions<sup><xref rid="R92" ref-type="bibr">92</xref></sup>), 2,473 phenotypic gene sets (based on 211,882 gene-phenotype pairs from the Mouse Genetics Initiative<sup><xref rid="R93" ref-type="bibr">93</xref></sup>), 737 Reactome pathways<sup><xref rid="R94" ref-type="bibr">94</xref></sup>, 184 KEGG pathways<sup><xref rid="R95" ref-type="bibr">95</xref></sup>, and 5,083 GO terms<sup><xref rid="R19" ref-type="bibr">19</xref></sup>. DEPICT uses the expression data to reconstitute the protein-protein interaction gene sets, mouse phenotype gene sets, Reactome pathway gene sets, KEGG pathway gene sets, and GO term gene sets. To avoid biasing the identification of genes and pathways covered by SNPs on the Metabochip, analyses were restricted to GWAS cohort data and included 226 WHRadjBMI SNPs in 78 non-overlapping loci with sex-combined <italic>P</italic><10<sup>−5</sup>. We used DEPICT to map genes to associated WHRadjBMI loci, which then allowed us to (1) systematically identify the most likely causal gene(s) in a given associated region, (2) identify reconstituted gene sets that were enriched in genes from associated regions, and (3) identify tissue and cell type annotations in which genes from associated regions were highly expressed. Associated regions were defined by all genes residing within LD (<italic>r<sup>2</sup></italic>>0.5) distance of the WHRadjBMI-associated index SNPs. Overlapping regions were merged, and SNPs that mapped near to or within the HLA region were excluded. The 93 WHRadjBMI SNPs with <italic>P</italic><10<sup>−5</sup> (clumping thresholds: HapMap release 27 CEU <italic>r<sup>2</sup></italic>=0.01, 500 kb) resulted in 78 non-overlapping regions. GWAS+Metabochip index SNPs were annotated with DEPICT-prioritized genes if the DEPICT (GWAS-only) SNP was located within 500 kb. To mark related gene sets, we first quantified significant gene sets’ pairwise overlap using a non-probabilistic version of the reconstituted gene sets and the Jaccard index measure. Groups of gene sets with mutual Jaccard indices >0.25 were subsequently referred to as meta gene sets and named by the most significant gene set in the group (<xref ref-type="supplementary-material" rid="SD2">Supplementary Table 18</xref> and <xref ref-type="fig" rid="F2">Fig. 2a</xref>). In <xref ref-type="fig" rid="F2">Figures 2a-b</xref>, gene sets with similarities between 0.1-0.25 were connected by an edge that was scaled according to degree of similarity. The Cytoscape tool was used to construct parts of <xref ref-type="fig" rid="F2">Figure 2</xref><sup><xref rid="R96" ref-type="bibr">96</xref></sup>. In <xref ref-type="fig" rid="F2">Figure 2c</xref>, we show the significance of all cell type annotations and annotations that were categorized as “Tissues” at the outermost level of the Medical Subject Heading ontology.</p></sec></sec></sec><sec sec-type="extended-data" id="S31"><title>Extended Data</title><fig id="F3" orientation="portrait" position="anchor"><label>Extended Data Figure 1</label><caption><title>Overall WHRadjBMI meta-analysis study design</title><p id="P52">Data (dashed lines) and analyses (solid lines) related to the genome-wide association study (GWAS) cohorts for waist-hip ratio adjusted for body mass index (WHRadjBMI) are colored red and those related to the Metabochip (MC) cohorts are colored blue. The two genomic control (λ<sub>GC</sub>) corrections (within-study and among-studies) performed on associations from each dataset are represented by gray-outlined circles. The λ<sub>GC</sub> corrections for the GWAS meta-analysis were based on all SNPs and the λ<sub>GC</sub> corrections for the Metabochip meta-analysis were based on a null set of 4,319 SNPs previously associated with QT interval. The joint meta-analysis of the GWAS and MC datasets is colored purple. All SNP counts reflect a sample size filter of <italic>N</italic> ≥ 50,000 subjects. Additional WHRadjBMI meta-analyses included Metabochip data from up to 14,371 subjects of East Asian, South Asian, or African American ancestry from eight cohorts. Counts for the meta-analyses of waist circumference (WC), hip circumference (HIP), and their BMI-adjusted counterparts (WCadjBMI and HIPadjBMI) differ from those of WHRadjBMI because some cohorts only had phenotype data available for one type of body circumference measurement (see <xref ref-type="supplementary-material" rid="SD2">Supplementary Table 2</xref>).</p></caption><graphic xlink:href="emss-61357-f0001"></graphic></fig><fig id="F4" orientation="portrait" position="anchor"><label>Extended Data Figure 2</label><caption><title>Female- and male-specific effects, phenotypic variances, and genetic correlations</title><p id="P53"><bold>a,</bold> Figure showing effect beta estimates for the 20 WHRadjBMI SNPs showing significant evidence of sexual dimorphism. Sex-specific effect betas and 95% confidence intervals for SNPs associated with waist-hip ratio adjusted for body mass index (WHRadjBMI) are shown as red circles and blue squares for women and men, respectively. The SNPs are classified into three categories: (<italic>i</italic>) those showing a female-specific effect (“Women SSE”), namely a significant effect in women and no effect in men (<italic>P</italic><sub>women</sub> < 5 × 10<sup>−8</sup>, <italic>P</italic><sub>men</sub> ≥ 0.05), (<italic>ii</italic>) those showing a pronounced female effect (“Women CED”), namely a significant effect in women and a less significant but directionally consistent effect in men (<italic>P</italic><sub>women</sub> < 5 × 10<sup>−8</sup>, 5 × 10<sup>−8</sup> < <italic>P</italic><sub>men</sub> ≤ 0.05); and (<italic>iii</italic>) those showing a male-specific effect (“Men SSE”), namely a significant effect in men and no effect in women (<italic>P</italic><sub>men</sub> < 5 × 10<sup>−8</sup>, <italic>P</italic><sub>women</sub> ≥ 0.05). Within each of the three categories, the loci were sorted by increasing <italic>P</italic> value of sex-based heterogeneity in the effect betas. <bold>b,</bold> Figure showing standardized sex-specific phenotypic variance components for six waist-related traits. Values are shown in men (M) and women (W) from the Swedish Twin Registry (<italic>N</italic> = 11,875). The ACE models are decomposed into additive genetic components (A) shown in black, common environmental components (C) in gray, and non-shared environmental components (E) in white. Components are shown for waist circumference (WC), hip circumference (HIP), waist-hip ratio (WHR), and their body mass index (BMI)-adjusted counterparts (WCadjBMI, HIPadjBMI, and WHRadjBMI). When the A component is different in men and women with <italic>P</italic> < 0.05 for a given trait, its name is marked with an asterisk. <bold>c,</bold> Table showing genetic correlations of waist-related traits with height, adjusted for age and body mass index. Genetic correlations of three traits with height were based on variance component models in the Framingham Heart Study and TWINGENE study (see Online Methods). WCadjBMI, waist circumference adjusted for BMI; WHRadjBMI, waist-hip ratio adjusted for BMI; HIPadjBMI, hip circumference adjusted for BMI.</p></caption><graphic xlink:href="emss-61357-f0002"></graphic></fig><fig id="F5" orientation="portrait" position="anchor"><label>Extended Data Figure 3</label><caption><title>Cumulative genetic risk scores for WHRadjBMI applied to the KORA study cohort</title><p id="P54"><bold>a,</bold> All subjects (<italic>N</italic> = 3,440, <italic>P</italic><sub>trend</sub> = 6.7 × 10<sup>−4</sup>). <bold>b,</bold> Only women (<italic>N</italic> = 1,750, <italic>P</italic><sub>trend</sub> = 1.0 × 10<sup>−11</sup>). <bold>c,</bold> Only men (<italic>N</italic> = 1,690, <italic>P</italic><sub>trend</sub> = 0.02). Each genetic risk score (GRS) illustrates the joint effect of the waist-hip ratio adjusted for body mass index (WHRadjBMI)-increasing alleles of the 49 identified variants from <xref ref-type="table" rid="T1">Table 1</xref> weighted by the relative effect sizes from the applicable sex-combined or sex-specific meta-analysis. The mean WHRadjBMI residual and 95% confidence interval is plotted for each GRS category (red dots). The histograms show each GRS is normally distributed in KORA (gray bars).</p></caption><graphic xlink:href="emss-61357-f0003"></graphic></fig><fig id="F6" orientation="portrait" position="anchor"><label>Extended Data Figure 4</label><caption><title>Heat map of unsupervised hierarchical clustering of the effects of 49 WHRadjBMI SNPs on 22 anthropometric and metabolic traits and diseases</title><p id="P55">The matrix of <italic>Z</italic>-scores representing the set of associations was scaled by row (locus name) and by column (trait) to range from −3 to 3. Negative values (blue) indicate that the waist-hip ratio adjusted for body mass index (WHRadjBMI)-increasing allele was associated with decreased values of the trait and positive values (red) indicate that this allele was associated with increased values of the trait. Dendrograms indicating the clustering relationships are shown to the left and above the heat map. The WHRadjBMI-increasing alleles at the 49 lead SNPs segregate into three major clusters comprised of alleles that associate with: 1) larger waist circumference adjusted for BMI (WCadjBMI) and smaller hip circumference adjusted for BMI (HIPadjBMI) (<italic>n</italic> = 30 SNPs); 2) taller stature and larger WCadjBMI (<italic>n</italic> = 8 SNPs); and 3) shorter stature and smaller HIPadjBMI (<italic>n</italic> = 11 SNPs). The three visually identified SNP clusters could be statistically distinguished with >90% confidence. Alleles of the first cluster were predominantly associated with lower high density lipoprotein (HDL) cholesterol and with higher triglycerides and fasting insulin adjusted for BMI (FIadjBMI). eGFRcrea, estimated glomerular filtration rate based on creatinine; LDL cholesterol, low-density lipoprotein cholesterol; UACR, urine albumin-to-creatinine ratio; BMD, bone mineral density.</p></caption><graphic xlink:href="emss-61357-f0004"></graphic></fig><fig id="F7" orientation="portrait" position="anchor"><label>Extended Data Figure 5</label><caption><title>Regulatory element overlap with WHRadjBMI-associated loci</title><p id="P56"><bold>a,</bold> Five variants associated with waist-hip ratio adjusted for body mass index (WHRadjBMI) and located ~77 kb upstream of the first <italic>CALCRL</italic> transcription start site overlap regions with genomic evidence of regulatory activity in endothelial cells. <bold>b,</bold> Five WHRadjBMI variants, including rs8817452, in a 1.1 kb region (box) ~250 kb downstream of the first <italic>LEKR1</italic> transcription start site overlap evidence of active enhancer activity in adipose nuclei. Signal enrichment tracks are from the ENCODE Integrative Analysis and the Roadmap Epigenomics track hubs on the UCSC Genome Browser. Transcripts are from the GENCODE basic annotation.</p></caption><graphic xlink:href="emss-61357-f0005"></graphic></fig><table-wrap id="T4" position="anchor" orientation="landscape"><label>Extended Data Table 1</label><caption><title>WHRadjBMI loci with multiple association signals in the sex-combined and/or sex-specific approximate conditional meta-analyses</title><p id="P57"><italic>P</italic> values and β coefficients for the association with WHRadjBMI from the joint model in the approximate conditional analysis of combined GWAS and Metabochip studies. SNPs selected by conditional analyses as independently associated with WHRadjBMI in a meta-analysis (sex-combined, women- or men-specific) have their respective summary statistics for these analyses marked in black and bold. SNPs not selected by a particular conditional analysis as independently associated are marked in gray and show the association analysis results for the SNP conditioned on the locus SNPs selected by GCTA. Sample sizes are from the unconditioned meta-analysis.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" valign="bottom" rowspan="1" colspan="1"></th><th align="center" valign="bottom" rowspan="1" colspan="1"></th><th align="center" valign="bottom" rowspan="1" colspan="1"></th><th align="center" valign="bottom" rowspan="1" colspan="1"></th><th align="center" valign="bottom" rowspan="1" colspan="1"></th><th align="center" valign="bottom" rowspan="1" colspan="1"></th><th colspan="3" align="center" valign="bottom" rowspan="1">Sex-combined</th><th colspan="3" align="center" valign="bottom" rowspan="1">Women</th><th colspan="3" align="center" valign="bottom" rowspan="1">Men</th><th rowspan="3" align="center" valign="middle" colspan="1">Sex diff. <italic>P</italic><sup><xref ref-type="table-fn" rid="TFN14">‡</xref></sup></th><th rowspan="3" align="center" valign="middle" colspan="1">CEU <italic>r</italic><sup>2</sup> with lead SNP</th></tr><tr><th colspan="15" align="center" valign="bottom" rowspan="1"><hr></hr></th></tr><tr><th align="center" valign="bottom" rowspan="1" colspan="1">Locus<xref ref-type="table-fn" rid="TFN12">*</xref></th><th align="center" valign="bottom" rowspan="1" colspan="1">SNP</th><th align="center" valign="bottom" rowspan="1" colspan="1">Position (bp)</th><th align="center" valign="bottom" rowspan="1" colspan="1">Nearest gene(s)</th><th align="center" valign="bottom" rowspan="1" colspan="1">EA<sup><xref ref-type="table-fn" rid="TFN13">†</xref></sup></th><th align="center" valign="bottom" rowspan="1" colspan="1">EAF</th><th align="center" valign="bottom" rowspan="1" colspan="1">β
</th><th align="center" valign="bottom" rowspan="1" colspan="1"><italic>P</italic></th><th align="center" valign="bottom" rowspan="1" colspan="1"><italic>N</italic></th><th align="center" valign="bottom" rowspan="1" colspan="1">β
</th><th align="center" valign="bottom" rowspan="1" colspan="1"><italic>P</italic></th><th align="center" valign="bottom" rowspan="1" colspan="1"><italic>N</italic></th><th align="center" valign="bottom" rowspan="1" colspan="1">β
</th><th align="center" valign="bottom" rowspan="1" colspan="1"><italic>P</italic></th><th align="center" valign="bottom" rowspan="1" colspan="1"><italic>N</italic></th></tr></thead><tbody><tr><td align="left" valign="bottom" rowspan="1" colspan="1"><italic>TBX15-</italic></td><td align="left" valign="bottom" rowspan="1" colspan="1">rs2645294</td><td align="center" valign="bottom" rowspan="1" colspan="1">119,376,110</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>WARS2</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">T</td><td align="center" valign="bottom" rowspan="1" colspan="1">0,6</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.031</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>7.60E-19</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>209,808</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.035</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.50E-14</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>116,596</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.014</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.20E-02</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,346</td><td align="center" valign="bottom" rowspan="1" colspan="1">4.90E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">Same</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"><italic>WARS2</italic></td><td align="left" valign="bottom" rowspan="1" colspan="1">rs1106529</td><td align="center" valign="bottom" rowspan="1" colspan="1">119,333,020</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>TBX15</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.8</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.016</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.40E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">209,930</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.021</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.10E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">116,663</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.034</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.80E-09</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>93,401</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">1.10E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.43</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"> [chr 1]</td><td align="left" valign="bottom" rowspan="1" colspan="1">rs12143789</td><td align="center" valign="bottom" rowspan="1" colspan="1">119,298,677</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>TBX15</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">C</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.2</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.026</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.00E-09</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>209,874</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.022</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.30E-04</td><td align="center" valign="bottom" rowspan="1" colspan="1">116,640</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.019</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.30E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,369</td><td align="center" valign="bottom" rowspan="1" colspan="1">7.10E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.06</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"></td><td align="left" valign="bottom" rowspan="1" colspan="1">rs12731372</td><td align="center" valign="bottom" rowspan="1" colspan="1">118,654,498</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>SPAG17</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">C</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.8</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.024</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.30E-09</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>209,856</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.02</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.10E-04</td><td align="center" valign="bottom" rowspan="1" colspan="1">116,636</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.028</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.40E-06</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,354</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.80E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">>500 kb</td></tr><tr><td colspan="17" align="left" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"><italic>GRB14-</italic></td><td align="left" valign="bottom" rowspan="1" colspan="1">rs1128249<sup><xref ref-type="table-fn" rid="TFN16">∥</xref></sup></td><td align="center" valign="bottom" rowspan="1" colspan="1">165,236,870</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>COBLL1</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">G</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.6</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.062</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>8.60E-19</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>209,414</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.093</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.00E-24</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>116,348</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">−0.002</td><td align="center" valign="bottom" rowspan="1" colspan="1">7.10E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,200</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>8.60E-22</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.93</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"><italic>COBLL1</italic></td><td align="left" valign="bottom" rowspan="1" colspan="1">rs12692737</td><td align="center" valign="bottom" rowspan="1" colspan="1">165,262,555</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>COBLL1</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.3</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.043</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.60E-08</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>203,265</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.134</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>2.70E-26</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>112,317</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.003</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.70E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">91,082</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>2.80E-21</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.71</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"> [chr 2]</td><td align="left" valign="bottom" rowspan="1" colspan="1">rs12692738</td><td align="center" valign="bottom" rowspan="1" colspan="1">165,266,498</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>COBLL1</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">T</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.8</td><td align="center" valign="bottom" rowspan="1" colspan="1">0 021</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.90E-05</td><td align="center" valign="bottom" rowspan="1" colspan="1">209,551</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.092</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>3.80E-20</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>116,474</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">−0.005</td><td align="center" valign="bottom" rowspan="1" colspan="1">4. 10E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,211</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.70E-18</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.3</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"></td><td align="left" valign="bottom" rowspan="1" colspan="1">rs17185198</td><td align="center" valign="bottom" rowspan="1" colspan="1">165,268,482</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>COBLL1</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.8</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.002</td><td align="center" valign="bottom" rowspan="1" colspan="1">7.40E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">207,702</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.072</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>8.50E-13</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>115,657</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">−0.004</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.80E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">92,179</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>8.00E-11</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.15</td></tr><tr><td colspan="17" align="left" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"><italic>PRBM1</italic></td><td align="left" valign="bottom" rowspan="1" colspan="1">rs13083798</td><td align="center" valign="bottom" rowspan="1" colspan="1">52,624,788</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>PRBM1</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.5</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.023</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.10E-11</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>209,128</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.013</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.20E-0l</td><td align="center" valign="bottom" rowspan="1" colspan="1">115,974</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.016</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.10E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,288</td><td align="center" valign="bottom" rowspan="1" colspan="1">7. 40E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.88</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"> [chr3]</td><td align="left" valign="bottom" rowspan="1" colspan="1">rs12489828</td><td align="center" valign="bottom" rowspan="1" colspan="1">52,542,054</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>NT5DC2</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">T</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.6</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.011</td><td align="center" valign="bottom" rowspan="1" colspan="1">6.50E-02</td><td align="center" valign="bottom" rowspan="1" colspan="1">204,485</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.029</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>2.60E-10</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>112,633</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">−0.015</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.90E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">91,986</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>7.20E-11</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.57</td></tr><tr><td colspan="17" align="left" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"><italic>MAP3K1</italic></td><td align="left" valign="bottom" rowspan="1" colspan="1">rs3936510</td><td align="center" valign="bottom" rowspan="1" colspan="1">55,896,623</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>MAP3K1</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">T</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.2</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.022</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.50E-06</td><td align="center" valign="bottom" rowspan="1" colspan="1">207,896</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.042</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>6.00E-12</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>115,645</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">−0.002</td><td align="center" valign="bottom" rowspan="1" colspan="1">8.20E-0l</td><td align="center" valign="bottom" rowspan="1" colspan="1">92,386</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>5.90E-07</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.88</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"> [chr 5]</td><td align="left" valign="bottom" rowspan="1" colspan="1">rs459193</td><td align="center" valign="bottom" rowspan="1" colspan="1">55,842,508</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>ANKRD55</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.3</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.026</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.60E-11</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>209,952</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.016</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.90E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">116,677</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.033</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>6.70E-09</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>93,410</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">2.30E-02</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.06</td></tr><tr><td colspan="17" align="left" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"><italic>VEGFA</italic></td><td align="left" valign="bottom" rowspan="1" colspan="1">rs998584<sup><xref ref-type="table-fn" rid="TFN15">§</xref></sup></td><td align="center" valign="bottom" rowspan="1" colspan="1">43,865,874</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>VEGFA</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.5</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.043</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.10E-29</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>189,620</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.065</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.00E-35</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>106,771</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.018</td><td align="center" valign="bottom" rowspan="1" colspan="1">8.20E-04</td><td align="center" valign="bottom" rowspan="1" colspan="1">82,983</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>3.10E-10</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.84</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"> [chr 6]</td><td align="left" valign="bottom" rowspan="1" colspan="1">rs4714699</td><td align="center" valign="bottom" rowspan="1" colspan="1">43,910,541</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>VEGFA</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">C</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.4</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.019</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.50E-07</td><td align="center" valign="bottom" rowspan="1" colspan="1">193,327</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.028</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.00E-08</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>107,987</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.007</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.90E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">85,475</td><td align="center" valign="bottom" rowspan="1" colspan="1">4.90E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.01</td></tr><tr><td colspan="17" align="left" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"><italic>RSP03</italic></td><td align="left" valign="bottom" rowspan="1" colspan="1">rs1936805<sup><xref ref-type="table-fn" rid="TFN15">§</xref></sup></td><td align="center" valign="bottom" rowspan="1" colspan="1">127,493,809</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>RSP03</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">T</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.5</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.038</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>2.00E-28</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>209,859</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.071</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>6.40E-37</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>116,602</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.031</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>3.30E-10</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>93,392</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>8.40E-08</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">Same</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"> [chr 6]</td><td align="left" valign="bottom" rowspan="1" colspan="1">rs11961815</td><td align="center" valign="bottom" rowspan="1" colspan="1">127,477,288</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>RSP03</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.8</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.022</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.00E-06</td><td align="center" valign="bottom" rowspan="1" colspan="1">209,679</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.037</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>6.50E-09</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>116,503</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.021</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.60E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,310</td><td align="center" valign="bottom" rowspan="1" colspan="1">6.90E-02</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.32</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"></td><td align="left" valign="bottom" rowspan="1" colspan="1">rs72959041<sup><xref ref-type="table-fn" rid="TFN16">∥</xref></sup></td><td align="center" valign="bottom" rowspan="1" colspan="1">127,496,586</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>RSP03</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.1</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.101</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>8.70E-15</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>72,472</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.05</td></tr><tr><td colspan="17" align="left" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"><italic>NFE2L3,</italic></td><td align="left" valign="bottom" rowspan="1" colspan="1">rs1534696</td><td align="center" valign="bottom" rowspan="1" colspan="1">26,363,764</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>SNX10</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">C</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.4</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.011</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.00E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">198,194</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.028</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>2.00E-08</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>111,643</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">−0.007</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.90E-0l</td><td align="center" valign="bottom" rowspan="1" colspan="1">86,685</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>2.20E-07</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">Same</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"><italic>SNX10</italic><sup><xref ref-type="table-fn" rid="TFN17">¶</xref></sup></td><td align="left" valign="bottom" rowspan="1" colspan="1">rs10245353</td><td align="center" valign="bottom" rowspan="1" colspan="1">25,825,139</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>NFE2L3</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.2</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.035</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>8.40E-16</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>210,008</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0 016</td><td align="center" valign="bottom" rowspan="1" colspan="1">1 30E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">116,704</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.027</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.40E-05</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,438</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.60E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">Same</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"> [chr 7]</td><td align="left" valign="bottom" rowspan="1" colspan="1">rs3902751</td><td align="center" valign="bottom" rowspan="1" colspan="1">25,828,164</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>NFE2L3</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.3</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.009</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.00E-0l</td><td align="center" valign="bottom" rowspan="1" colspan="1">209,969</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.039</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.20E-14</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>116,676</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.019</td><td align="center" valign="bottom" rowspan="1" colspan="1">8.40E-04</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,427</td><td align="center" valign="bottom" rowspan="1" colspan="1">7.40E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.608<sup><xref ref-type="table-fn" rid="TFN17">¶</xref></sup></td></tr><tr><td colspan="17" align="left" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"><italic>HOXC13</italic></td><td align="left" valign="bottom" rowspan="1" colspan="1">rs1443512</td><td align="center" valign="bottom" rowspan="1" colspan="1">52,628,951</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>HOXC13</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.2</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.016</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.70E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">209,980</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.04</td><td align="center" valign="bottom" rowspan="1" colspan="1">1. 10E-14</td><td align="center" valign="bottom" rowspan="1" colspan="1">116,688</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.012</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.00E-02</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,425</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.80E-04</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">Same</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"> [chr 12]</td><td align="left" valign="bottom" rowspan="1" colspan="1">rs10783615</td><td align="center" valign="bottom" rowspan="1" colspan="1">52,636,040</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>HOXC12</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">G</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.1</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.037</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>6.70E-14</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>209,368</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.023</td><td align="center" valign="bottom" rowspan="1" colspan="1">8.50E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">116,356</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.022</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.80E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,146</td><td align="center" valign="bottom" rowspan="1" colspan="1">9.30E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.59</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"></td><td align="left" valign="bottom" rowspan="1" colspan="1">rs2071449<sup><xref ref-type="table-fn" rid="TFN15">§</xref></sup></td><td align="center" valign="bottom" rowspan="1" colspan="1">52,714,278</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>HOXC4/5/6</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.4</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.028</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>5.00E-15</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>206,953</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.026</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.60E-08</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>114,259</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.029</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>3.40E-08</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>92,829</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">6.60E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">0</td></tr><tr><td colspan="17" align="left" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"><italic>CCDC92</italic></td><td align="left" valign="bottom" rowspan="1" colspan="1">rs4765219</td><td align="center" valign="bottom" rowspan="1" colspan="1">123,006,063</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>CCDC92</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">C</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.7</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.025</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>6.90E-12</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>209,807</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.032</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>2.50E-11</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>116,592</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.018</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.30E-04</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,350</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.80E-02</td><td align="center" valign="bottom" rowspan="1" colspan="1">Same</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"> [chr 12]</td><td align="left" valign="bottom" rowspan="1" colspan="1">rs863750</td><td align="center" valign="bottom" rowspan="1" colspan="1">123,071,397</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>ZNF664</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">T</td><td align="center" valign="bottom" rowspan="1" colspan="1">0 6</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.022</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>3.90E-10</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>209,371</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>0.031</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.60E-11</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>116,367</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.015</td><td align="center" valign="bottom" rowspan="1" colspan="1">4.00E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,138</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.80E-02</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.02</td></tr></tbody></table><table-wrap-foot><fn id="TFN12"><label>*</label><p id="P58">Locus and lead SNPs are defined by <xref ref-type="table" rid="T1">Table 1</xref></p></fn><fn id="TFN13"><label>†</label><p id="P59">The effect allele is the WHRadjBMI-increasing allele in the sex-combined analysis.</p></fn><fn id="TFN14"><label>‡</label><p id="P60">Test for sex difference in conditional analysis based on the effect correlation estimate from primary analyses; values significant at the table-wise Bonferroni threshold of 0.05 / 25=2×10<sup>−3</sup> are marked in bold.</p></fn><fn id="TFN15"><label>§</label><p id="P61">SNPs selected by conditional analysis in the sex-combined analysis; proxies were selected by joint conditional analysis in the women- and/or men-specific analyses.</p></fn><fn id="TFN16"><label>∥</label><p id="P62">SNP not present in the sex-specific meta-analyses due to sample size filter requiring <italic>N</italic> ≥ 50,000; sample size from GCTA.</p></fn><fn id="TFN17"><label>¶</label><p id="P63">At <italic>NFE2L3-SNX10</italic>, different lead SNPs were identified in the European and all-ancestry analyses but LD is reported with respect to rs10245353. Chr, chromosome; EA, effect allele; EAF, effect allele frequency.</p></fn></table-wrap-foot></table-wrap><table-wrap id="T5" position="anchor" orientation="portrait"><label>Extended Data Table 2</label><caption><title>Enrichments of 49 WHRadjBMI signal SNPs with metabolic and anthropometric traits</title><p id="P64">The 49 waist-hip ratio adjusted for body mass index (WHRadjBMI) SNPs were tested for association with other traits by GWAS meta-analyses performed by other groups (see Online Methods). The maximum sample size available is shown overall or separately for 61 cases/controls. <italic>N</italic> indicates the number of the total SNPs for which the WHRadjBMI-increasing allele is associated with the trait in the concordant direction (increased levels, except for HDL-C, adiponectin, and BMI). One-sided binomial <italic>P</italic> values test whether this number is greater than expected by chance (null <italic>P</italic> = 0.5 and null <italic>P</italic> = 0.025, respectively). The tests do not account for correlation between WHRadjBMI and the tested traits. <italic>P</italic> values representing significant column-wise enrichment (<italic>P</italic> < 0.05 / 23 tests) are marked in red and bold.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" valign="bottom" rowspan="1" colspan="1"></th><th align="center" valign="bottom" rowspan="1" colspan="1"></th><th colspan="3" align="center" valign="bottom" rowspan="1">SNPs in concordant direction</th><th colspan="3" align="center" valign="bottom" rowspan="1">SNPs in concordant direction with <italic>P</italic> < 0.05</th></tr><tr><th colspan="8" align="center" valign="bottom" rowspan="1"><hr></hr></th></tr><tr><th align="center" valign="bottom" rowspan="1" colspan="1">Trait</th><th align="center" valign="bottom" rowspan="1" colspan="1">Max. sample size</th><th align="center" valign="bottom" rowspan="1" colspan="1"><italic>N</italic></th><th align="center" valign="bottom" rowspan="1" colspan="1">Total</th><th align="center" valign="bottom" rowspan="1" colspan="1"><italic>P</italic></th><th align="center" valign="bottom" rowspan="1" colspan="1"><italic>N</italic></th><th align="center" valign="bottom" rowspan="1" colspan="1">Total</th><th align="center" valign="bottom" rowspan="1" colspan="1"><italic>P</italic></th></tr></thead><tbody><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Type 2 diabetes (T2D)</td><td align="center" valign="bottom" rowspan="1" colspan="1">86,200</td><td align="center" valign="bottom" rowspan="1" colspan="1">37</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>2.35E-04</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">16</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>3.56E-14</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Fasting glucose (FG)</td><td align="center" valign="bottom" rowspan="1" colspan="1">132,996</td><td align="center" valign="bottom" rowspan="1" colspan="1">35</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.90E-03</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">8</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>2.75E-05</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Fasting insulin adjusted for BMI (FladjBMI)</td><td align="center" valign="bottom" rowspan="1" colspan="1">103,496</td><td align="center" valign="bottom" rowspan="1" colspan="1">45</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.11E-10</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">36</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.04E-47</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">2-hour glucose (G120)</td><td align="center" valign="bottom" rowspan="1" colspan="1">42,853</td><td align="center" valign="bottom" rowspan="1" colspan="1">33</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.06E-02</td><td align="center" valign="bottom" rowspan="1" colspan="1">7</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>2.09E-04</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Diastolic blood pressure (DBP)</td><td align="center" valign="bottom" rowspan="1" colspan="1">69,760</td><td align="center" valign="bottom" rowspan="1" colspan="1">34</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1">4.70E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">10</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>3.21 E-07</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Systolic blood pressure (SBP)</td><td align="center" valign="bottom" rowspan="1" colspan="1">69,774</td><td align="center" valign="bottom" rowspan="1" colspan="1">38</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>7.10E-05</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">6</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.36E-03</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Body mass index (BMI)</td><td align="center" valign="bottom" rowspan="1" colspan="1">322,120</td><td align="center" valign="bottom" rowspan="1" colspan="1">40</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.63E-06</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">23</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.42E-24</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Height</td><td align="center" valign="bottom" rowspan="1" colspan="1">253,209</td><td align="center" valign="bottom" rowspan="1" colspan="1">25</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.00E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">14</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.10E-11</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">High-density lipoprotein cholesterol (HDL-C)</td><td align="center" valign="bottom" rowspan="1" colspan="1">187,142</td><td align="center" valign="bottom" rowspan="1" colspan="1">45</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.11E-10</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">24</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.22E-25</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Low-density lipoprotein cholesterol (LDL-C)</td><td align="center" valign="bottom" rowspan="1" colspan="1">173,067</td><td align="center" valign="bottom" rowspan="1" colspan="1">33</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.06E-02</td><td align="center" valign="bottom" rowspan="1" colspan="1">12</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>2.32E-09</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Triglycerides (TG)</td><td align="center" valign="bottom" rowspan="1" colspan="1">177,838</td><td align="center" valign="bottom" rowspan="1" colspan="1">46</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>3.49E-11</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">29</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>6.02E-34</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Adiponectin</td><td align="center" valign="bottom" rowspan="1" colspan="1">29,347</td><td align="center" valign="bottom" rowspan="1" colspan="1">41</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>9.82E-07</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">20</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.28E-19</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Endometriosis</td><td align="center" valign="bottom" rowspan="1" colspan="1">1,364/7,060</td><td align="center" valign="bottom" rowspan="1" colspan="1">24</td><td align="center" valign="bottom" rowspan="1" colspan="1">45</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.83E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">4</td><td align="center" valign="bottom" rowspan="1" colspan="1">45</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.58E-02</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Nephropathy (in Chinese subjects)</td><td align="center" valign="bottom" rowspan="1" colspan="1">1,194/902</td><td align="center" valign="bottom" rowspan="1" colspan="1">18</td><td align="center" valign="bottom" rowspan="1" colspan="1">43</td><td align="center" valign="bottom" rowspan="1" colspan="1">8.89E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">0</td><td align="center" valign="bottom" rowspan="1" colspan="1">43</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.00E+00</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Nephropathy (in Italian subjects)</td><td align="center" valign="bottom" rowspan="1" colspan="1">1,045/1,340</td><td align="center" valign="bottom" rowspan="1" colspan="1">20</td><td align="center" valign="bottom" rowspan="1" colspan="1">43</td><td align="center" valign="bottom" rowspan="1" colspan="1">7.29E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">1</td><td align="center" valign="bottom" rowspan="1" colspan="1">43</td><td align="center" valign="bottom" rowspan="1" colspan="1">6.63E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Estimated glomerular filtration rate of creatinine (eGFRcrea)</td><td align="center" valign="bottom" rowspan="1" colspan="1">74,354</td><td align="center" valign="bottom" rowspan="1" colspan="1">29</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.26E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">3</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.24E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Chronic kidney disease (CKD)</td><td align="center" valign="bottom" rowspan="1" colspan="1">74,354</td><td align="center" valign="bottom" rowspan="1" colspan="1">17</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1">9.89E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">2</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.47E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Urine albumin-to-creatinine ratio (UACR)</td><td align="center" valign="bottom" rowspan="1" colspan="1">31,580</td><td align="center" valign="bottom" rowspan="1" colspan="1">22</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1">8.04E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">2</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.47E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Menopause</td><td align="center" valign="bottom" rowspan="1" colspan="1">87,802</td><td align="center" valign="bottom" rowspan="1" colspan="1">28</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.96E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">1</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1">7.11E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Menarche</td><td align="center" valign="bottom" rowspan="1" colspan="1">38,968</td><td align="center" valign="bottom" rowspan="1" colspan="1">23</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1">7.16E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">2</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.47E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Coronary artery disease (CAD)</td><td align="center" valign="bottom" rowspan="1" colspan="1">191,198</td><td align="center" valign="bottom" rowspan="1" colspan="1">27</td><td align="center" valign="bottom" rowspan="1" colspan="1">48</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.35E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">9</td><td align="center" valign="bottom" rowspan="1" colspan="1">48</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>2.64E-06</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Femoral neck bone mineral density (FN-BMD)</td><td align="center" valign="bottom" rowspan="1" colspan="1">32,960</td><td align="center" valign="bottom" rowspan="1" colspan="1">25</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.00E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">4</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.40E-02</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Lumbar spine bone mineral density (LS-BMD)</td><td align="center" valign="bottom" rowspan="1" colspan="1">31,798</td><td align="center" valign="bottom" rowspan="1" colspan="1">28</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.96E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">3</td><td align="center" valign="bottom" rowspan="1" colspan="1">49</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.24E-01</td></tr></tbody></table></table-wrap><table-wrap id="T6" position="anchor" orientation="portrait"><label>Extended Data Table 3</label><caption><title>Enrichment of 49 WHRadjBMI-associated loci in epigenomic datasets</title><p id="P65">Enrichment of waist-hip ratio adjusted for BMI (WHRadjBMI)-associated loci in regulatory elements from selected WHRadjBMI-relevant tissues. <italic>P</italic> values are derived using a sum of binomial distributions (see Methods). <italic>P</italic> values below a Bonferroni-corrected threshold for 60 tests of 8.3 × 10<sup>−4</sup> are indicated in bold font. The binomial based <italic>P</italic> values are similar to <italic>P</italic> values generated from 10,000 permutation tests. Dashes indicate that datasets were not available.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" valign="bottom" rowspan="1" colspan="1">Sample</th><th align="center" valign="bottom" rowspan="1" colspan="1">Tissue</th><th align="center" valign="bottom" rowspan="1" colspan="1">DNase I HS</th><th align="center" valign="bottom" rowspan="1" colspan="1">H3K4me1</th><th align="center" valign="bottom" rowspan="1" colspan="1">H3K27ac</th><th align="center" valign="bottom" rowspan="1" colspan="1">H3K4me3</th><th align="center" valign="bottom" rowspan="1" colspan="1">H3K9ac</th></tr></thead><tbody><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Adipose Nuclei</td><td align="left" valign="bottom" rowspan="1" colspan="1">Adipose</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>9.6E-06</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.2E-13</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.0051</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.0010</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">GM12878</td><td align="left" valign="bottom" rowspan="1" colspan="1">Blood</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.029</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.032</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.32</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.050</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.030</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Osteoblasts</td><td align="left" valign="bottom" rowspan="1" colspan="1">Bone</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.082</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.1E-06</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.8E-04</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">9.9E-04</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Astrocytes</td><td align="left" valign="bottom" rowspan="1" colspan="1">Brain</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.013</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.0044</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.0077</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.0047</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Anterior Caudate</td><td align="left" valign="bottom" rowspan="1" colspan="1">Brain</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>2.9E-04</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.026</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.018</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.015</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Mid Frontal Lobe</td><td align="left" valign="bottom" rowspan="1" colspan="1">Brain</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.029</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.023</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.023</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.036</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Substantia Nigra</td><td align="left" valign="bottom" rowspan="1" colspan="1">Brain</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.047</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.023</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.045</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Cerebellum</td><td align="left" valign="bottom" rowspan="1" colspan="1">Brain</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.048</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Cerebrum Frontal</td><td align="left" valign="bottom" rowspan="1" colspan="1">Brain</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.054</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Frontal Cortex</td><td align="left" valign="bottom" rowspan="1" colspan="1">Brain</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.022</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">HUVEC</td><td align="left" valign="bottom" rowspan="1" colspan="1">Endothelial</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>5.0E-05</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.011</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.0011</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.023</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.040</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Adult Liver</td><td align="left" valign="bottom" rowspan="1" colspan="1">Liver</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.0057</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.15</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.29</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">HepG2</td><td align="left" valign="bottom" rowspan="1" colspan="1">Liver</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.015</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>7.7E-05</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.023</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>5.0E-04</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.085</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Hepatocytes</td><td align="left" valign="bottom" rowspan="1" colspan="1">Liver</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.59</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Huh-7</td><td align="left" valign="bottom" rowspan="1" colspan="1">Liver</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.0024</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Myoctye</td><td align="left" valign="bottom" rowspan="1" colspan="1">Muscle</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>2.9E-04</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.3E-04</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.0026</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.015</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.0041</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">PSOAS</td><td align="left" valign="bottom" rowspan="1" colspan="1">Muscle</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.0012</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Skeletal Muscle</td><td align="left" valign="bottom" rowspan="1" colspan="1">Muscle</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>7.3E-04</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>7.8E-05</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">0.0075</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.25</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Pancreatic Islet</td><td align="left" valign="bottom" rowspan="1" colspan="1">Pancreatic Islets</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.40</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.68</td><td align="center" valign="bottom" rowspan="1" colspan="1">-</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.37</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.61</td></tr></tbody></table></table-wrap><table-wrap id="T7" position="anchor" orientation="portrait"><label>Extended Data Table 4</label><caption><title>Candidate genes at new loci associated with additional waist and hip-related traits</title><p id="P66">Candidate genes for loci shown on <xref ref-type="table" rid="T3">Table 3</xref> based on secondary analyses or literature review. Further details are provided in other <xref ref-type="supplementary-material" rid="SD2">Supplementary Tables and the Supplementary Note</xref>. Loci are shown in order of chromosome and position.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" valign="bottom" rowspan="1" colspan="1">SNP</th><th align="center" valign="bottom" rowspan="1" colspan="1">Trait</th><th align="center" valign="bottom" rowspan="1" colspan="1">Chr</th><th align="center" valign="bottom" rowspan="1" colspan="1">Locus</th><th align="center" valign="bottom" rowspan="1" colspan="1">Expression QTL (<italic>P</italic> < 10<sup>−5</sup>)<xref ref-type="table-fn" rid="TFN18">*</xref></th><th align="center" valign="bottom" rowspan="1" colspan="1">GRAIL (<italic>P</italic> < 0.05)<sup><xref ref-type="table-fn" rid="TFN19">†</xref></sup></th><th align="center" valign="bottom" rowspan="1" colspan="1">Literature<sup><xref ref-type="table-fn" rid="TFN20">‡</xref></sup></th><th align="center" valign="bottom" rowspan="1" colspan="1">Other GWAS signals<sup><xref ref-type="table-fn" rid="TFN21">§</xref></sup></th><th align="center" valign="bottom" rowspan="1" colspan="1">nsSNPs and CNVs<break></break>(<italic>r</italic><sup>2</sup>> 0.7)<sup><xref ref-type="table-fn" rid="TFN22">∥</xref></sup></th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">rs10925060</td><td align="center" valign="top" rowspan="1" colspan="1">WCadjBMI</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>OR2W5-NRLP3</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>NLRP3</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs10929925</td><td align="center" valign="top" rowspan="1" colspan="1">HIP</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>SOX11</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>SOX11</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>SOX11</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs2124969</td><td align="center" valign="top" rowspan="1" colspan="1">WCadjBMI</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>ITGB6</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>PLA2R1</italic> (SAT)</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>ITGB6</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">Idiopathic membranous nephropathy (<italic>PLA2R1, LY75, ITGB6: RBMS1</italic>)</td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs1664789</td><td align="center" valign="top" rowspan="1" colspan="1">WCadjBMI</td><td align="center" valign="top" rowspan="1" colspan="1">5</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>ARL15</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>ARL15</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs 17472426</td><td align="center" valign="top" rowspan="1" colspan="1">WCadjBMI</td><td align="center" valign="top" rowspan="1" colspan="1">5</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>CCNJL</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>FABP6</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs722585</td><td align="center" valign="top" rowspan="1" colspan="1">HIPadjBMI</td><td align="center" valign="top" rowspan="1" colspan="1">6</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>GMDS</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs7739232</td><td align="center" valign="top" rowspan="1" colspan="1">HIPadjBMI</td><td align="center" valign="top" rowspan="1" colspan="1">6</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>KLHL31</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>KLHL31</italic> (SAT)</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>KLHL31-GCLC-ELVOL</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs1144</td><td align="center" valign="top" rowspan="1" colspan="1">WCadjBMI</td><td align="center" valign="top" rowspan="1" colspan="1">7</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>SRPK2</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>SRPK2 (LCL), MLL5</italic> (Omental)</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs13241538</td><td align="center" valign="top" rowspan="1" colspan="1">HIPadjBMI</td><td align="center" valign="top" rowspan="1" colspan="1">7</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>KLF14</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>KLF14</italic> (SAT)</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>KLF14</italic></td><td align="center" valign="top" rowspan="1" colspan="1">HDL cholesterol, Triglycerides, Type 2 diabetes: <italic>KLF14</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs2398893</td><td align="center" valign="top" rowspan="1" colspan="1">WHR</td><td align="center" valign="top" rowspan="1" colspan="1">9</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>PTPDC1</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>BARX1</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs7044106</td><td align="center" valign="top" rowspan="1" colspan="1">HIPadjBMI</td><td align="center" valign="top" rowspan="1" colspan="1">9</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>C5</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs11607976</td><td align="center" valign="top" rowspan="1" colspan="1">HIP</td><td align="center" valign="top" rowspan="1" colspan="1">11</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>MYEOV</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>CCND1</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>FGF19-FGF4-FGF3</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs1784203</td><td align="center" valign="top" rowspan="1" colspan="1">WCadjBMI</td><td align="center" valign="top" rowspan="1" colspan="1">11</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>KIAA1731</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs1394461</td><td align="center" valign="top" rowspan="1" colspan="1">WHR</td><td align="center" valign="top" rowspan="1" colspan="1">11</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>CNTN5</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs319564</td><td align="center" valign="top" rowspan="1" colspan="1">WHR</td><td align="center" valign="top" rowspan="1" colspan="1">13</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>GPC6</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>GPC6</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs4985155</td><td align="center" valign="top" rowspan="1" colspan="1">HIP</td><td align="center" valign="top" rowspan="1" colspan="1">16</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>PDXDC1</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>PDXDC1</italic> (SAT)</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>PLA2G10-NTAN1</italic></td><td align="center" valign="top" rowspan="1" colspan="1">Femoral neck bone mineral density, Lumbar spine bone mineral density, Plasma phospholipid levels, Metabolic traits, Height: <italic>PDXDC1, NTAN1</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>NTAN1</italic> (S287P), <italic>NTAN1</italic> (H283N)</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs2047937</td><td align="center" valign="top" rowspan="1" colspan="1">WCadjBMI</td><td align="center" valign="top" rowspan="1" colspan="1">16</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>ZNF423</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>ZNF423-CNEP1R1</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs2034088</td><td align="center" valign="top" rowspan="1" colspan="1">HIPadjBMI</td><td align="center" valign="top" rowspan="1" colspan="1">17</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>VPS53</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>VPS53</italic> (Liver, SAT), <italic>FAM101B</italic> (Omental, SAT)</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs1053593</td><td align="center" valign="top" rowspan="1" colspan="1">HIPadjBMI</td><td align="center" valign="top" rowspan="1" colspan="1">22</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>HMGXB4</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>TOM1</italic> (PBMC), <italic>HMGXB4</italic> (Blood, SAT)</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>HMGXB4</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>HMGXB4</italic> (G165V),<break></break>CNVR8147.1</td></tr></tbody></table><table-wrap-foot><fn id="TFN18"><label>*</label><p id="P67">Gene transcript levels associated with SNP genotype (expression QTL) in the indicated tissue(s).</p></fn><fn id="TFN19"><label>†</label><p id="P68">Genes in pathways identified as enriched by GRAIL analysis.</p></fn><fn id="TFN20"><label>‡</label><p id="P69">Strongest candidate genes identified based on manual literature review.</p></fn><fn id="TFN21"><label>§</label><p id="P70">Traits associated at <italic>P</italic> < 5 × 10<sup>−8</sup> in GWAS lookups or in the GWAS catalog using the index SNP or a proxy in high linkage disequilibrium (LD) (<italic>r</italic><sup>2</sup> > 0.7), and the genes(s) named in those reports.</p></fn><fn id="TFN22"><label>∥</label><p id="P71">Nonsynonymous variants (nsSNPs) and copy number variants (CNVs) with tag SNPs in high LD with index SNP based on a 1000 Genomes CEU reference panel. DEPICT analysis was not performed for loci associated with these traits. Chr, Chromosome; WCadjBMI, waist circumference adjusted for body mass index (BMI); HIPadjBMI, hip circumference adjusted for BMI; WHR, waist-to-hip ratio.</p></fn></table-wrap-foot></table-wrap></sec><sec sec-type="supplementary-material" id="SM"><title>Supplementary Material</title><supplementary-material content-type="local-data" id="SD1"><label>1</label><media xlink:href="NIHMS61357-supplement-1.docx" orientation="portrait" xlink:type="simple" id="d37e10216" position="anchor"></media></supplementary-material><supplementary-material content-type="local-data" id="SD2"><label>2</label><media xlink:href="NIHMS61357-supplement-2.pdf" orientation="portrait" xlink:type="simple" id="d37e10220" position="anchor"></media></supplementary-material><supplementary-material content-type="local-data" id="SD3"><label>ST1-4</label><media xlink:href="NIHMS61357-supplement-ST1-4.zip" orientation="portrait" xlink:type="simple" id="d37e10224" position="anchor"></media></supplementary-material><supplementary-material content-type="local-data" id="SD4"><label>ST11,15-16,18-19</label><media xlink:href="NIHMS61357-supplement-ST11_15-16_18-19.zip" orientation="portrait" xlink:type="simple" id="d37e10228" position="anchor"></media></supplementary-material><supplementary-material content-type="local-data" id="SD5"><label>ST21-23,26-28</label><media xlink:href="NIHMS61357-supplement-ST21-23_26-28.zip" orientation="portrait" xlink:type="simple" id="d37e10232" position="anchor"></media></supplementary-material><supplementary-material content-type="local-data" id="SD6"><label>ST25</label><media xlink:href="NIHMS61357-supplement-ST25.zip" orientation="portrait" xlink:type="simple" id="d37e10236" position="anchor"></media></supplementary-material><supplementary-material content-type="local-data" id="SD7"><label>ST8</label><media xlink:href="NIHMS61357-supplement-ST8.zip" orientation="portrait" xlink:type="simple" id="d37e10240" position="anchor"></media></supplementary-material></sec></body><back><ack id="S32"><title>Acknowledgments</title><p>We thank the more than 224,000 volunteers who participated in this study. 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Three index SNPs near <italic>HOXC6-HOXC13</italic> (<bold>a</bold><italic><bold>–</bold></italic><bold>c</bold>) and four near <italic>TBX15-WARS2-SPAG17</italic> (<bold>d</bold><italic><bold>–</bold></italic><bold>g</bold>) were identified through approximate conditional analyses of sex-combined or sex-specific associations (values shown as <italic>P<sub>conditional</sub></italic> <5×10<sup>−8</sup>, see Methods). The signals are distinguished by both color and shape, and linkage disequilibrium (<italic>r</italic><sup>2</sup>) of nearby SNPs is shown by color intensity gradient.</p></caption><graphic xlink:href="emss-61357-f0006"></graphic></fig><fig id="F2" orientation="portrait" position="float"><label>Figure 2</label><caption><title>Gene set enrichment and tissue expression of genes at WHRadjBMI-associated loci (GWAS-only <italic>P</italic><10<sup>−5</sup>)</title><p><bold>a,</bold> Reconstituted gene sets found to be significantly enriched by DEPICT (FDR<5%) are represented as nodes, with pairwise overlap denoted by the width of connecting lines and empirical enrichment <italic>P</italic> value indicated by color intensity (darker is more significant). <bold>b</bold>, The ‘Decreased Liver Weight’ meta-node, which consisted of 12 overlapping gene sets, including adiponectin signaling and insulin sensitivity. <bold>c,</bold> Based on expression patterns in 37,427 human microarray samples, annotations found to be significantly enriched by DEPICT are shown, grouped by type and significance.</p></caption><graphic xlink:href="emss-61357-f0007"></graphic></fig><table-wrap id="T1" position="float" orientation="portrait"><label>Table 1</label><caption><title>WHRadjBMI loci achieving genome-wide significance (<italic>P</italic><5×10<sup>−8</sup>) in sex-combined and/or sex-specific meta-analyses</title></caption><table frame="below" rules="groups"><thead><tr><th align="center" valign="bottom" rowspan="1" colspan="1"></th><th align="center" valign="bottom" rowspan="1" colspan="1"></th><th align="center" valign="bottom" rowspan="1" colspan="1"></th><th align="center" valign="bottom" rowspan="1" colspan="1"></th><th align="center" valign="bottom" rowspan="1" colspan="1"></th><th colspan="10" align="center" valign="bottom" rowspan="1"><hr></hr></th></tr><tr><th align="center" valign="bottom" rowspan="1" colspan="1"></th><th align="center" valign="bottom" rowspan="1" colspan="1"></th><th align="center" valign="bottom" rowspan="1" colspan="1"></th><th align="center" valign="bottom" rowspan="1" colspan="1"></th><th align="center" valign="bottom" rowspan="1" colspan="1"></th><th colspan="3" align="center" valign="bottom" rowspan="1">Sex-combined</th><th colspan="3" align="center" valign="bottom" rowspan="1">Women</th><th colspan="3" align="center" valign="bottom" rowspan="1">Men</th><th align="center" valign="bottom" rowspan="1" colspan="1">Sex diff.<italic>P</italic><sup><xref ref-type="table-fn" rid="TFN2">b</xref></sup></th></tr><tr><th colspan="15" align="center" valign="bottom" rowspan="1"><hr></hr></th></tr><tr><th align="center" valign="bottom" rowspan="1" colspan="1">SNP</th><th align="center" valign="bottom" rowspan="1" colspan="1">Chr</th><th align="center" valign="bottom" rowspan="1" colspan="1">Locus</th><th align="center" valign="bottom" rowspan="1" colspan="1">EA<sup><xref ref-type="table-fn" rid="TFN1">a</xref></sup></th><th align="center" valign="bottom" rowspan="1" colspan="1">EAF</th><th align="center" valign="bottom" rowspan="1" colspan="1">β</th><th align="center" valign="bottom" rowspan="1" colspan="1"><italic>P</italic></th><th align="center" valign="bottom" rowspan="1" colspan="1"><italic>N</italic></th><th align="center" valign="bottom" rowspan="1" colspan="1">β</th><th align="center" valign="bottom" rowspan="1" colspan="1"><italic>P</italic></th><th align="center" valign="bottom" rowspan="1" colspan="1"><italic>N</italic></th><th align="center" valign="bottom" rowspan="1" colspan="1">β</th><th align="center" valign="bottom" rowspan="1" colspan="1"><italic>P</italic></th><th align="center" valign="bottom" rowspan="1" colspan="1"><italic>N</italic></th><th align="center" valign="bottom" rowspan="1" colspan="1"></th></tr></thead><tbody><tr><td colspan="15" align="left" valign="bottom" rowspan="1"><bold><italic>Novel loci achieving genome-wide significance in European-ancestry meta-analyses</italic></bold></td></tr><tr><td colspan="15" align="left" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs905938</td><td align="center" valign="bottom" rowspan="1" colspan="1">1</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>DCST2</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">T</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.74</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.025</td><td align="center" valign="bottom" rowspan="1" colspan="1">7.3E-10</td><td align="center" valign="bottom" rowspan="1" colspan="1">207,867</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.034</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.9E-10</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">115,536</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.015</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.10E-02</td><td align="center" valign="bottom" rowspan="1" colspan="1">92,461</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.6E-02</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs10919388</td><td align="center" valign="bottom" rowspan="1" colspan="1">1</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>GORAB</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">C</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.72</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.024</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.2E-09</td><td align="center" valign="bottom" rowspan="1" colspan="1">181,049</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.033</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.8E-10</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">102,446</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.013</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.98E-02</td><td align="center" valign="bottom" rowspan="1" colspan="1">78,738</td><td align="center" valign="bottom" rowspan="1" colspan="1">9.8E-03</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs1385167</td><td align="center" valign="bottom" rowspan="1" colspan="1">2</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>MEIS1</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">G</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.15</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.029</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold><bold>1.9E-09</bold></bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">206,619</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.023</td><td align="center" valign="bottom" rowspan="1" colspan="1">4.0E-04</td><td align="center" valign="bottom" rowspan="1" colspan="1">114,668</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.036</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.32E-07</td><td align="center" valign="bottom" rowspan="1" colspan="1">92,085</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.6E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs1569135</td><td align="center" valign="bottom" rowspan="1" colspan="1">2</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>CALCRL</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.53</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.021</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>5.6E-10</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">209,906</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.023</td><td align="center" valign="bottom" rowspan="1" colspan="1">6.9E-07</td><td align="center" valign="bottom" rowspan="1" colspan="1">116,642</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.019</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.48E-04</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,398</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.8E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs10804591</td><td align="center" valign="bottom" rowspan="1" colspan="1">3</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>PLXND1</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.79</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.025</td><td align="center" valign="bottom" rowspan="1" colspan="1">6.6E-09</td><td align="center" valign="bottom" rowspan="1" colspan="1">209,921</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.040</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>6.1E-13</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">116,667</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.004</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.28E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,387</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>5.7E-06</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs17451107</td><td align="center" valign="bottom" rowspan="1" colspan="1">3</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>LEKR1</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">T</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.61</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.026</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.1E-12</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">207,795</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.023</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.0E-06</td><td align="center" valign="bottom" rowspan="1" colspan="1">115,735</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.030</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.42E-08</td><td align="center" valign="bottom" rowspan="1" colspan="1">92,194</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.5E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs3805389</td><td align="center" valign="bottom" rowspan="1" colspan="1">4</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>NMU</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.28</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.012</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.5E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">209,218</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.027</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.6E-08</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">116,226</td><td align="center" valign="bottom" rowspan="1" colspan="1">−0.007</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.09E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,125</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.6E-06</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs9991328</td><td align="center" valign="bottom" rowspan="1" colspan="1">4</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>FAM13A</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">T</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.49</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.019</td><td align="center" valign="bottom" rowspan="1" colspan="1">4.5E-08</td><td align="center" valign="bottom" rowspan="1" colspan="1">209,925</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.028</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>3.4E-10</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">116,652</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.007</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.69E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,407</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>8.5E-04</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs303084</td><td align="center" valign="bottom" rowspan="1" colspan="1">4</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>SPATA5-FGF2</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.80</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.023</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>3.9E-08</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">209,941</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.029</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.4E-07</td><td align="center" valign="bottom" rowspan="1" colspan="1">116,662</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.016</td><td align="center" valign="bottom" rowspan="1" colspan="1">9.91E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,412</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.1E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs9687846</td><td align="center" valign="bottom" rowspan="1" colspan="1">5</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>MAP3K1</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.19</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.024</td><td align="center" valign="bottom" rowspan="1" colspan="1">7.1E-08</td><td align="center" valign="bottom" rowspan="1" colspan="1">208,181</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.041</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>3.8E-12</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">115,897</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.000</td><td align="center" valign="bottom" rowspan="1" colspan="1">9.69E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">92,417</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.3E-06</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs6556301</td><td align="center" valign="bottom" rowspan="1" colspan="1">5</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>FGFR4</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">T</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.36</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.022</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>2.6E-08</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">178,874</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.018</td><td align="center" valign="bottom" rowspan="1" colspan="1">7.1E-04</td><td align="center" valign="bottom" rowspan="1" colspan="1">101,638</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.029</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.00E-06</td><td align="center" valign="bottom" rowspan="1" colspan="1">77,370</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.4E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs7759742</td><td align="center" valign="bottom" rowspan="1" colspan="1">6</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>BTNL2</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.51</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.023</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.4E-11</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">208,263</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.024</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.7E-07</td><td align="center" valign="bottom" rowspan="1" colspan="1">115,648</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.023</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.49E-06</td><td align="center" valign="bottom" rowspan="1" colspan="1">92,749</td><td align="center" valign="bottom" rowspan="1" colspan="1">8.6E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs1776897</td><td align="center" valign="bottom" rowspan="1" colspan="1">6</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>HMGA1</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">G</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.08</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.030</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.1E-05</td><td align="center" valign="bottom" rowspan="1" colspan="1">177,879</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.052</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>6.8E-09</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">100,516</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.003</td><td align="center" valign="bottom" rowspan="1" colspan="1">7.42E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">77,497</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.8E-04</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs7801581</td><td align="center" valign="bottom" rowspan="1" colspan="1">7</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>HOXA11</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">T</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.24</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.027</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>3.7E-10</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">195,215</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.025</td><td align="center" valign="bottom" rowspan="1" colspan="1">7.7E-06</td><td align="center" valign="bottom" rowspan="1" colspan="1">108,866</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.029</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.39E-06</td><td align="center" valign="bottom" rowspan="1" colspan="1">86,483</td><td align="center" valign="bottom" rowspan="1" colspan="1">6.9E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs7830933</td><td align="center" valign="bottom" rowspan="1" colspan="1">8</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>NKX2-6</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.77</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.022</td><td align="center" valign="bottom" rowspan="1" colspan="1">7.4E-08</td><td align="center" valign="bottom" rowspan="1" colspan="1">209,766</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.037</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.2E-12</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">116,567</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.001</td><td align="center" valign="bottom" rowspan="1" colspan="1">8.35E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,333</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.4E-06</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs12679556</td><td align="center" valign="bottom" rowspan="1" colspan="1">8</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>MSC</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">G</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.25</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.027</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>2.1E-11</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">203,826</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.033</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.1E-10</td><td align="center" valign="bottom" rowspan="1" colspan="1">114,369</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.017</td><td align="center" valign="bottom" rowspan="1" colspan="1">4.15E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">89,591</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.8E-02</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs10991437</td><td align="center" valign="bottom" rowspan="1" colspan="1">9</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>ABCA1</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.11</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.031</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.0E-08</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">209,941</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.040</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.8E-08</td><td align="center" valign="bottom" rowspan="1" colspan="1">116,644</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.022</td><td align="center" valign="bottom" rowspan="1" colspan="1">6.13E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,430</td><td align="center" valign="bottom" rowspan="1" colspan="1">7.2E-02</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs7917772</td><td align="center" valign="bottom" rowspan="1" colspan="1">10</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>SFXN2</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.62</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.014</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.6E-05</td><td align="center" valign="bottom" rowspan="1" colspan="1">209,642</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.027</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>5.5E-09</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">116,514</td><td align="center" valign="bottom" rowspan="1" colspan="1">−0.001</td><td align="center" valign="bottom" rowspan="1" colspan="1">8.57E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,263</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>2.3E-05</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs11231693</td><td align="center" valign="bottom" rowspan="1" colspan="1">11</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>MACROD1-VEGFB</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.06</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.041</td><td align="center" valign="bottom" rowspan="1" colspan="1">4.5E-08</td><td align="center" valign="bottom" rowspan="1" colspan="1">198,072</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.068</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>2.7E-11</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">110,164</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.009</td><td align="center" valign="bottom" rowspan="1" colspan="1">4.20E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">88,043</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>2.5E-05</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs4765219</td><td align="center" valign="bottom" rowspan="1" colspan="1">12</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>CCDC92</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">C</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.67</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.028</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.6E-15</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">209,807</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.037</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.0E-14</td><td align="center" valign="bottom" rowspan="1" colspan="1">116,592</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.018</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.32E-04</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,350</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.7E-03</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs8042543</td><td align="center" valign="bottom" rowspan="1" colspan="1">15</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>KLF13</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">C</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.78</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.026</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.2E-09</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">208,255</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.023</td><td align="center" valign="bottom" rowspan="1" colspan="1">6.7E-05</td><td align="center" valign="bottom" rowspan="1" colspan="1">115,760</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.030</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.01E-06</td><td align="center" valign="bottom" rowspan="1" colspan="1">92,629</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.6E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs8030605</td><td align="center" valign="bottom" rowspan="1" colspan="1">15</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>RFX7</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.14</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.030</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>8.8E-09</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">208,374</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.031</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.0E-05</td><td align="center" valign="bottom" rowspan="1" colspan="1">115,864</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.031</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.91E-05</td><td align="center" valign="bottom" rowspan="1" colspan="1">92,644</td><td align="center" valign="bottom" rowspan="1" colspan="1">9.9E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs1440372</td><td align="center" valign="bottom" rowspan="1" colspan="1">15</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>SMAD6</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">C</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.71</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.024</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.1E-10</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">207,447</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.022</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.1E-05</td><td align="center" valign="bottom" rowspan="1" colspan="1">115,201</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.027</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.39E-06</td><td align="center" valign="bottom" rowspan="1" colspan="1">92,380</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.2E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs2925979</td><td align="center" valign="bottom" rowspan="1" colspan="1">16</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>CMIP</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">T</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.31</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.018</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.2E-06</td><td align="center" valign="bottom" rowspan="1" colspan="1">207,828</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.032</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>3.4E-11</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">115,431</td><td align="center" valign="bottom" rowspan="1" colspan="1">−0.002</td><td align="center" valign="bottom" rowspan="1" colspan="1">7.86E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">92,531</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.2E-06</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs4646404</td><td align="center" valign="bottom" rowspan="1" colspan="1">17</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>PEMT</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">G</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.67</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.027</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.4E-11</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">198,196</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.034</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.3E-11</td><td align="center" valign="bottom" rowspan="1" colspan="1">115,337</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.017</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.45E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">87,857</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.6E-02</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs8066985</td><td align="center" valign="bottom" rowspan="1" colspan="1">17</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>KCNJ2</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.50</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.018</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.4E-07</td><td align="center" valign="bottom" rowspan="1" colspan="1">209,977</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.026</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.0E-09</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">116,683</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.007</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.89E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,428</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.8E-03</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs12454712</td><td align="center" valign="bottom" rowspan="1" colspan="1">18</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>BCL2</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">T</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.61</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.016</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.0E-04</td><td align="center" valign="bottom" rowspan="1" colspan="1">169,793</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.035</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.1E-09</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">96,182</td><td align="center" valign="bottom" rowspan="1" colspan="1">−0.007</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.45E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">73,576</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.6E-07</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs12608504</td><td align="center" valign="bottom" rowspan="1" colspan="1">19</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>JUND</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.36</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.022</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>8.8E-10</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">209,990</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.017</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.6E-04</td><td align="center" valign="bottom" rowspan="1" colspan="1">116,689</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.028</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.05E-07</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,435</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.2E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs4081724</td><td align="center" valign="bottom" rowspan="1" colspan="1">19</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>CEBPA</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">G</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.85</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.035</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>7.4E-12</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">207,418</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.033</td><td align="center" valign="bottom" rowspan="1" colspan="1">9.2E-07</td><td align="center" valign="bottom" rowspan="1" colspan="1">115,322</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.039</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.41E-07</td><td align="center" valign="bottom" rowspan="1" colspan="1">92,230</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.0E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs979012</td><td align="center" valign="bottom" rowspan="1" colspan="1">20</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>BMP2</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">T</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.34</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.027</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>3.3E-14</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">209,941</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.026</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.0E-07</td><td align="center" valign="bottom" rowspan="1" colspan="1">116,668</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.028</td><td align="center" valign="bottom" rowspan="1" colspan="1">6.59E-08</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,407</td><td align="center" valign="bottom" rowspan="1" colspan="1">6.7E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs224333</td><td align="center" valign="bottom" rowspan="1" colspan="1">20</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>GDF5</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">G</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.62</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.020</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.6E-08</td><td align="center" valign="bottom" rowspan="1" colspan="1">208,025</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.009</td><td align="center" valign="bottom" rowspan="1" colspan="1">7.4E-02</td><td align="center" valign="bottom" rowspan="1" colspan="1">115,803</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.036</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>9.00E-12</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">92,356</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>6.4E-05</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs6090583</td><td align="center" valign="bottom" rowspan="1" colspan="1">20</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>EYA2</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.48</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.022</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>6.2E-11</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">209,435</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.029</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.8E-10</td><td align="center" valign="bottom" rowspan="1" colspan="1">116,382</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.015</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.37E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,187</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.2E-02</td></tr><tr><td colspan="15" align="left" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td colspan="15" align="left" valign="bottom" rowspan="1"><bold><italic>Novel loci achieving genome-wide significance in all-ancestry meta-analyses</italic></bold></td></tr><tr><td colspan="15" align="left" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs1534696</td><td align="center" valign="bottom" rowspan="1" colspan="1">7</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>SNX10</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">C</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.43</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.011</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.3E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">212,501</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.027</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>2.1E-08</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">118,187</td><td align="center" valign="bottom" rowspan="1" colspan="1">−0.006</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.64E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">92,243</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.1E-06</td></tr><tr><td colspan="15" align="left" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td colspan="15" align="left" valign="bottom" rowspan="1"><bold><italic>Previously reported loci achieving genome-wide significance in European-ancestry meta-analyses</italic></bold></td></tr><tr><td colspan="15" align="left" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs2645294</td><td align="center" valign="bottom" rowspan="1" colspan="1">1</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>TBX15-WARS2</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">T</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.58</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.031</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.7E-19</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">209,808</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.035</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.5E-14</td><td align="center" valign="bottom" rowspan="1" colspan="1">116,596</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.027</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.46E-07</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,346</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.0E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs714515</td><td align="center" valign="bottom" rowspan="1" colspan="1">1</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>DNM3-PIGC</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">G</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.43</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.027</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.4E-15</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">203,401</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.029</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.8E-10</td><td align="center" valign="bottom" rowspan="1" colspan="1">113,939</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.025</td><td align="center" valign="bottom" rowspan="1" colspan="1">8.54E-07</td><td align="center" valign="bottom" rowspan="1" colspan="1">89,596</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.1E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs2820443</td><td align="center" valign="bottom" rowspan="1" colspan="1">1</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>LYPLAL1</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">T</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.72</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.035</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.3E-21</td><td align="center" valign="bottom" rowspan="1" colspan="1">209,975</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.062</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>5.7E-35</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">116,672</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.002</td><td align="center" valign="bottom" rowspan="1" colspan="1">6.91E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,437</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>2.6E-17</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs10195252</td><td align="center" valign="bottom" rowspan="1" colspan="1">2</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>GRB14-COBLL1</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">T</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.59</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.027</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.9E-15</td><td align="center" valign="bottom" rowspan="1" colspan="1">209,395</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.052</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.7E-30</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">116,329</td><td align="center" valign="bottom" rowspan="1" colspan="1">−0.003</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.33E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,199</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>2.4E-17</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs17819328</td><td align="center" valign="bottom" rowspan="1" colspan="1">3</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>PPARG</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">G</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.43</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.021</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.4E-09</td><td align="center" valign="bottom" rowspan="1" colspan="1">208,809</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.035</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.6E-14</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">116,072</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.005</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.26E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">92,871</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>5.1E-06</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs2276824</td><td align="center" valign="bottom" rowspan="1" colspan="1">3</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>PBRM1<sup><xref ref-type="table-fn" rid="TFN3">c</xref></sup></italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">C</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.43</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.024</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>3.2E-11</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">208,901</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.028</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.7E-09</td><td align="center" valign="bottom" rowspan="1" colspan="1">116,128</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.020</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.35E-04</td><td align="center" valign="bottom" rowspan="1" colspan="1">92,907</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.0E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs2371767</td><td align="center" valign="bottom" rowspan="1" colspan="1">3</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>ADAMTS9</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">G</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.72</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.036</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.6E-20</td><td align="center" valign="bottom" rowspan="1" colspan="1">194,506</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.056</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.2E-26</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">108,624</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.012</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.49E-02</td><td align="center" valign="bottom" rowspan="1" colspan="1">86,016</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>3.6E-09</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs1045241</td><td align="center" valign="bottom" rowspan="1" colspan="1">5</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>TNFAIP8-HSD17B4</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">C</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.71</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.019</td><td align="center" valign="bottom" rowspan="1" colspan="1">4.4E-07</td><td align="center" valign="bottom" rowspan="1" colspan="1">209,710</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.035</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>6.6E-12</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">116,560</td><td align="center" valign="bottom" rowspan="1" colspan="1">−0.001</td><td align="center" valign="bottom" rowspan="1" colspan="1">9.29E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,284</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>8.3E-07</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs7705502</td><td align="center" valign="bottom" rowspan="1" colspan="1">5</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>CPEB4</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.33</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.027</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.7E-14</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">209,827</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.027</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.9E-08</td><td align="center" valign="bottom" rowspan="1" colspan="1">116,609</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.027</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.30E-07</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,352</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.0E+00</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs1294410</td><td align="center" valign="bottom" rowspan="1" colspan="1">6</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>LY86</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">C</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.63</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.031</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>2.0E-18</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">209,830</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.037</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.6E-15</td><td align="center" valign="bottom" rowspan="1" colspan="1">116,624</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.025</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.37E-06</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,340</td><td align="center" valign="bottom" rowspan="1" colspan="1">6.3E-02</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs1358980</td><td align="center" valign="bottom" rowspan="1" colspan="1">6</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>VEGFA</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">T</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.47</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.039</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.1E-27</td><td align="center" valign="bottom" rowspan="1" colspan="1">206,862</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.060</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>3.7E-34</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">115,047</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.015</td><td align="center" valign="bottom" rowspan="1" colspan="1">4.02E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">91,949</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>3.7E-11</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs1936805</td><td align="center" valign="bottom" rowspan="1" colspan="1">6</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>RSPO3</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">T</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.51</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.043</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>3.6E-35</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">209,859</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.052</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.7E-30</td><td align="center" valign="bottom" rowspan="1" colspan="1">116,602</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.031</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.08E-10</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,392</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.0E-03</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs10245353</td><td align="center" valign="bottom" rowspan="1" colspan="1">7</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>NFE2L3</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.20</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.035</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>8.4E-16</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">210,008</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.041</td><td align="center" valign="bottom" rowspan="1" colspan="1">7.9E-13</td><td align="center" valign="bottom" rowspan="1" colspan="1">116,704</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.027</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.43E-05</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,438</td><td align="center" valign="bottom" rowspan="1" colspan="1">7.2E-02</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs10842707</td><td align="center" valign="bottom" rowspan="1" colspan="1">12</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>ITPR2-SSPN</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">T</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.23</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.032</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.4E-16</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">210,023</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.041</td><td align="center" valign="bottom" rowspan="1" colspan="1">6.1E-15</td><td align="center" valign="bottom" rowspan="1" colspan="1">116,704</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.022</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.44E-04</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,453</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.1E-02</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs1443512</td><td align="center" valign="bottom" rowspan="1" colspan="1">12</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>HOXC13</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.24</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.028</td><td align="center" valign="bottom" rowspan="1" colspan="1">6.9E-13</td><td align="center" valign="bottom" rowspan="1" colspan="1">209,980</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.040</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.1E-14</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">116,688</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.013</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.77E-02</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,425</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.6E-04</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs2294239</td><td align="center" valign="bottom" rowspan="1" colspan="1">22</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>ZNRF3</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.59</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.025</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>7.2E-13</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">209,454</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.028</td><td align="center" valign="bottom" rowspan="1" colspan="1">6.9E-10</td><td align="center" valign="bottom" rowspan="1" colspan="1">116,414</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.024</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.31E-06</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,173</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.0E-01</td></tr></tbody></table><table-wrap-foot><p><italic>P</italic> values and β coefficients for the association with WHRadjBMI in the meta-analyses of combined GWAS and Metabochip studies. The smallest <italic>P</italic> value for each SNP is shown in bold.</p><fn id="TFN1"><label>a</label><p id="P73">The effect allele is the WHRadjBMI-increasing allele in the sex-combined analysis.</p></fn><fn id="TFN2"><label>b</label><p id="P74">Test for sex difference; values significant at the table-wise Bonferroni threshold of 0.05/49=1.02× 10<sup>−3</sup> are marked in bold.</p></fn><fn id="TFN3"><label>c</label><p id="P75">Locus previously named <italic>NISCH-STAB1</italic>. Additional analyses that showed no significant evidence of heterogeneity between studies or due to ascertainment are provided in <xref ref-type="supplementary-material" rid="SD2">Supplementary Tables 27 and 28 (Supplementary Note)</xref>. Chr, chromosome; EA, effect allele; EAF, effect allele frequency.</p></fn></table-wrap-foot></table-wrap><table-wrap id="T2" position="float" orientation="portrait"><label>Table 2</label><caption><title>Candidate genes at new WHRadjBMI loci</title></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" valign="bottom" rowspan="1" colspan="1">SNP</th><th align="center" valign="bottom" rowspan="1" colspan="1">Locus</th><th align="center" valign="bottom" rowspan="1" colspan="1">Expression QTL (<italic>P</italic><10<sup>−5</sup>)<sup><xref ref-type="table-fn" rid="TFN4">a</xref></sup></th><th align="center" valign="bottom" rowspan="1" colspan="1">GRAIL (<italic>P</italic><0.05)<sup><xref ref-type="table-fn" rid="TFN5">b</xref></sup></th><th align="center" valign="bottom" rowspan="1" colspan="1">DEPICT (FDR<0.05)<sup><xref ref-type="table-fn" rid="TFN6">c</xref></sup></th><th align="center" valign="bottom" rowspan="1" colspan="1">Literature<sup><xref ref-type="table-fn" rid="TFN7">d</xref></sup></th><th align="center" valign="bottom" rowspan="1" colspan="1">Other GWAS signals<sup><xref ref-type="table-fn" rid="TFN8">e</xref></sup></th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">rs905938</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>DCST2</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>ZBTB7B</italic> (PB, Blood)</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs10919388</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>GORAB</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs1385167</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>MEIS1</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>MEIS1</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs1569135</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>CALCRL</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>TFPI</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>CALCRL</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs10804591</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>PLXND1</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>PLXND1</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs17451107</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>LEKR1</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>TIPARP</italic> (S,O), <italic>LEKR1</italic> (S)</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">Birthweight: <italic>CCNL1, LEKR1</italic></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs3805389</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>NMU</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>NMU</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs9991328</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>FAM13A</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>FAM13A</italic> (S)</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>FAM13A</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">FI: <italic>FAM13A</italic></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs303084</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>SPATA5-FGF2</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>FGF2</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>FGF2, NUDT6, SPRY1</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs9687846</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>MAP3K1</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>MAP3K1</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>MAP3K1</italic></td><td align="center" valign="top" rowspan="1" colspan="1">FI, TG: <italic>ANKRD55, MAP3K1</italic></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs6556301</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>FGFR4</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>MXD3</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>FGFR4</italic></td><td align="center" valign="top" rowspan="1" colspan="1">Height</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs7759742</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>BTNL2</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>HLA-DRA</italic> (S), <italic>KLHL31</italic> (S)</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">(not analyzed)</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs1776897</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>HMGA1</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">(not analyzed)</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>HMGA1</italic></td><td align="center" valign="top" rowspan="1" colspan="1">Height: <italic>HMGA1, C6orf106, LBH</italic></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs1534696</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>SNX10</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>SNX10</italic> (S), <italic>CBX3</italic> (S)</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>SNX10</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs7801581</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>HOXA11</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>HOXA11</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>HOXA11</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>HOXA11</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs7830933</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>NKX2-6</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>STC1</italic> (S)</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>NKX2-6, STC1</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs12679556</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>MSC</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>EYA1</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>RP11-1102P16.1</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>MSC, EYA1</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs10991437</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>ABCA1</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>ABCA1</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs7917772</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>SFXN2</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>SFXN2</italic></td><td align="center" valign="top" rowspan="1" colspan="1">Height</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs11231693</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>MACROD1-VEGFB</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>VEGFB</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>MACROD1</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>MACROD1, VEGFB</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs4765219</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>CCDC92</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>CCDC92</italic> (S, O, L), <italic>ZNF664</italic> (S, O)</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>FAM101A</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">Adiponectin, FI, HDL, TG: CCDC92, <italic>ZNF664</italic></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs8042543</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>KLF13</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>KLF13</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>KLF13</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs8030605</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>RFX7</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs1440372</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>SMAD6</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>SMAD6</italic> (Blood)</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>SMAD6</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>SMAD6</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>SMAD6</italic></td><td align="center" valign="top" rowspan="1" colspan="1">Height</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs2925979</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>CMIP</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>CMIP</italic> (S)</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>CMIP, PLCG2</italic></td><td align="center" valign="top" rowspan="1" colspan="1">Adiponectin, FI, HDL: <italic>CMIP</italic></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs4646404</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>PEMT</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>PEMT</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>PEMT</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs8066985</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>KCNJ2</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>KCNJ2</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs12454712</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>BCL2</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>BCL2</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs12608504</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>JUND</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>KIAA1683</italic> (PB, O), <italic>JUND</italic> (LCL)</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>JUND</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>JUND</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs4081724</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>CEBPA</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>CEBPA</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>CEBPA, CEBPG</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs979012</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>BMP2</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>BMP2</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>BMP2</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>BMP2</italic></td><td align="center" valign="top" rowspan="1" colspan="1">Height: <italic>BMP2</italic></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs224333</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>GDF5</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>CEP250</italic> (S, O), <italic>UQCC</italic> (Blood, S, O, L, LCL)</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>GDF5</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>GDF5</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>GDF5</italic></td><td align="center" valign="top" rowspan="1" colspan="1">Height: <italic>GDF5, UQCC</italic></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs6090583</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>EYA2</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td><td align="center" valign="top" rowspan="1" colspan="1"><italic>EYA2</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>EYA2</italic></td><td align="center" valign="top" rowspan="1" colspan="1"><italic>EYA2</italic></td><td align="center" valign="top" rowspan="1" colspan="1">-</td></tr></tbody></table><table-wrap-foot><p>Candidate genes based on secondary analyses or literature review. Details are provided in <xref ref-type="supplementary-material" rid="SD2">Supplementary Tables 8-9, 11-13, 15, 19, 21 and the Supplementary Note</xref>. The only nonsynonymous variant in high LD with an index SNP was <italic>GDF5</italic> S276A. No copy number variants were identified.</p><fn id="TFN4"><label>a</label><p id="P76">Gene transcript levels associated with the SNP in the indicated tissue(s): PB, peripheral blood mononuclear cells; S, subcutaneous adipose; O, omental adipose; L, liver; lcl, lymphoblastoid cell line.</p></fn><fn id="TFN5"><label>b</label><p id="P77">Genes in pathways identified as enriched by GRAIL analysis</p></fn><fn id="TFN6"><label>c</label><p id="P78">Significant pathway genes derived by DEPICT using GWAS-only results.</p></fn><fn id="TFN7"><label>d</label><p id="P79">Most plausible candidate genes based on literature review.</p></fn><fn id="TFN8"><label>e</label><p id="P80">Traits associated at P<5 × 10<sup>−8</sup> in GWAS or the GWAS catalog using the index SNP or a proxy, and the genes(s) named. FI, fasting insulin adjusted for BMI; HDL, high-density lipoprotein cholesterol; tg, triglycerides.</p></fn></table-wrap-foot></table-wrap><table-wrap id="T3" position="float" orientation="landscape"><label>Table 3</label><caption><title>New loci achieving genome-wide evidence of association (P<5×10<sup>−8</sup>) with additional waist and hip circumference traits</title></caption><table frame="below" rules="groups"><thead><tr><th align="center" valign="middle" rowspan="1" colspan="1"></th><th align="center" valign="middle" rowspan="1" colspan="1"></th><th align="center" valign="middle" rowspan="1" colspan="1"></th><th align="center" valign="middle" rowspan="1" colspan="1"></th><th align="center" valign="middle" rowspan="1" colspan="1"></th><th align="center" valign="middle" rowspan="1" colspan="1"></th><th colspan="10" align="center" valign="middle" rowspan="1"><hr></hr></th></tr><tr><th align="center" valign="middle" rowspan="1" colspan="1"></th><th align="center" valign="middle" rowspan="1" colspan="1"></th><th align="center" valign="middle" rowspan="1" colspan="1"></th><th align="center" valign="middle" rowspan="1" colspan="1"></th><th align="center" valign="middle" rowspan="1" colspan="1"></th><th align="center" valign="middle" rowspan="1" colspan="1"></th><th colspan="3" align="center" valign="middle" rowspan="1">Sex-combined</th><th colspan="3" align="center" valign="middle" rowspan="1">Women</th><th colspan="3" align="center" valign="middle" rowspan="1">Men</th><th align="center" valign="middle" rowspan="1" colspan="1">Sex diff.</th></tr><tr><th colspan="16" align="center" valign="middle" rowspan="1"><hr></hr></th></tr><tr><th align="center" valign="middle" rowspan="1" colspan="1">SNP</th><th align="center" valign="middle" rowspan="1" colspan="1">Trait</th><th align="center" valign="middle" rowspan="1" colspan="1">Chr</th><th align="center" valign="middle" rowspan="1" colspan="1">Locus</th><th align="center" valign="middle" rowspan="1" colspan="1">EA<sup><xref ref-type="table-fn" rid="TFN9">a</xref></sup></th><th align="center" valign="middle" rowspan="1" colspan="1">EAF</th><th align="center" valign="middle" rowspan="1" colspan="1">β
</th><th align="center" valign="middle" rowspan="1" colspan="1"><italic>P</italic></th><th align="center" valign="middle" rowspan="1" colspan="1"><italic>N</italic></th><th align="center" valign="middle" rowspan="1" colspan="1">β
</th><th align="center" valign="middle" rowspan="1" colspan="1"><italic>P</italic></th><th align="center" valign="middle" rowspan="1" colspan="1"><italic>N</italic></th><th align="center" valign="middle" rowspan="1" colspan="1">β
</th><th align="center" valign="middle" rowspan="1" colspan="1"><italic>P</italic></th><th align="center" valign="middle" rowspan="1" colspan="1"><italic>N</italic></th><th align="center" valign="middle" rowspan="1" colspan="1"><italic>P</italic><sup><xref ref-type="table-fn" rid="TFN10">b</xref></sup></th></tr></thead><tbody><tr><td colspan="11" align="left" valign="bottom" rowspan="1"><bold><italic>Loci achieving genome-wide significance in European-ancestry meta-analyses</italic></bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"></td><td align="center" valign="bottom" rowspan="1" colspan="1"></td><td align="center" valign="bottom" rowspan="1" colspan="1"></td><td align="center" valign="bottom" rowspan="1" colspan="1"></td><td align="center" valign="bottom" rowspan="1" colspan="1"></td></tr><tr><td colspan="16" align="left" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs10925060</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>WCadjBMI</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">1</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>OR2W5-NLRP3</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">T</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.03</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.017</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.2E-05</td><td align="center" valign="bottom" rowspan="1" colspan="1">140,515</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.002</td><td align="center" valign="bottom" rowspan="1" colspan="1">6.8E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">85,186</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.045</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>9.1E-13</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">55,522</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.7E-08</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs10929925</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>HIP</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">2</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>SOX11</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">C</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.55</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.020</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.5E-08</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">207,648</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.021</td><td align="center" valign="bottom" rowspan="1" colspan="1">9.0E-06</td><td align="center" valign="bottom" rowspan="1" colspan="1">115,428</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.018</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.2E-04</td><td align="center" valign="bottom" rowspan="1" colspan="1">92,499</td><td align="center" valign="bottom" rowspan="1" colspan="1">6.1E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs2124969</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>WCadjBMI</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">2</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>ITGB6</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">C</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.42</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.020</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>7.1E-09</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">231,284</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.016</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.5E-04</td><td align="center" valign="bottom" rowspan="1" colspan="1">127,437</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.025</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.3E-07</td><td align="center" valign="bottom" rowspan="1" colspan="1">104,039</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.4E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs17472426</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>WCadjBMI</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">5</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>CCNJL</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">T</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.92</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.014</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.1E-02</td><td align="center" valign="bottom" rowspan="1" colspan="1">217,564</td><td align="center" valign="bottom" rowspan="1" colspan="1">−0.014</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.0E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">119,804</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.052</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.3E-08</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">97,954</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>3.9E-08</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs7739232</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>HIPadjBMI</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">6</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>KLHL31</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.07</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.037</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.4E-05</td><td align="center" valign="bottom" rowspan="1" colspan="1">131,877</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.063</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.0E-08</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">80,475</td><td align="center" valign="bottom" rowspan="1" colspan="1">−0.004</td><td align="center" valign="bottom" rowspan="1" colspan="1">7.5E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">51,589</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>2.9E-05</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs13241538</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>HIPadjBMI</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">7</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>KLF14</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">C</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.48</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.017</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.6E-06</td><td align="center" valign="bottom" rowspan="1" colspan="1">210,935</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.033</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>9.9E-14</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">117,210</td><td align="center" valign="bottom" rowspan="1" colspan="1">−0.003</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.0E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,911</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>2.0E-09</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs7044106</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>HIPadjBMI</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">9</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>C5</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">C</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.24</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.023</td><td align="center" valign="bottom" rowspan="1" colspan="1">4.1E-05</td><td align="center" valign="bottom" rowspan="1" colspan="1">143,412</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.039</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>5.7E-09</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">86,733</td><td align="center" valign="bottom" rowspan="1" colspan="1">−0.003</td><td align="center" valign="bottom" rowspan="1" colspan="1">6.9E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">56,865</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.3E-05</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs11607976</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>HIP</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">11</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>MYEOV</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">C</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.70</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.022</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.2E-08</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">212,815</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.019</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.9E-04</td><td align="center" valign="bottom" rowspan="1" colspan="1">118,391</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.024</td><td align="center" valign="bottom" rowspan="1" colspan="1">7.7E-06</td><td align="center" valign="bottom" rowspan="1" colspan="1">94,701</td><td align="center" valign="bottom" rowspan="1" colspan="1">4.4E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs1784203</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>WCadjBMI</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">11</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>KIAA1731</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.01</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.031</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.3E-08</td><td align="center" valign="bottom" rowspan="1" colspan="1">63,892</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.000</td><td align="center" valign="bottom" rowspan="1" colspan="1">9.9E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">35,539</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.075</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.0E-19</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">28,353</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.2E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs1394461</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>WHR</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">11</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>CNTN5</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">C</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.25</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.017</td><td align="center" valign="bottom" rowspan="1" colspan="1">4.7E-04</td><td align="center" valign="bottom" rowspan="1" colspan="1">144,349</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.035</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>3.6E-08</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">87,441</td><td align="center" valign="bottom" rowspan="1" colspan="1">−0.011</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.6E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">57,094</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.1E-06</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs319564</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>WHR</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">13</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>GPC6</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">C</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.45</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.014</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.4E-05</td><td align="center" valign="bottom" rowspan="1" colspan="1">212,137</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.003</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.3E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">117,970</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.027</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.6E-08</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">94,350</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>6.0E-05</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs2047937</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>WCadjBMI</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">16</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>ZNF423</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">C</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.50</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.019</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.7E-08</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">231,009</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.022</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.5E-07</td><td align="center" valign="bottom" rowspan="1" colspan="1">127,288</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.014</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.6E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">103,914</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.0E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs2034088</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>HIPadjBMI</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">17</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>VPS53</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">T</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.53</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.021</td><td align="center" valign="bottom" rowspan="1" colspan="1">4.8E-09</td><td align="center" valign="bottom" rowspan="1" colspan="1">210,737</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.028</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>9.6E-10</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">117,142</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.014</td><td align="center" valign="bottom" rowspan="1" colspan="1">6.5E-03</td><td align="center" valign="bottom" rowspan="1" colspan="1">93,781</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.5E-02</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs1053593</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>HIPadjBMI</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">22</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>HMGXB4</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">T</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.65</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.021</td><td align="center" valign="bottom" rowspan="1" colspan="1">3.9E-08</td><td align="center" valign="bottom" rowspan="1" colspan="1">202,070</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.029</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>1.8E-09</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">114,347</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.011</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.1E-02</td><td align="center" valign="bottom" rowspan="1" colspan="1">87,908</td><td align="center" valign="bottom" rowspan="1" colspan="1">6.2E-03</td></tr><tr><td colspan="16" align="left" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td colspan="10" align="left" valign="bottom" rowspan="1"><bold><italic>Loci achieving genome-wide significance in all-ancestry meta-analyses</italic></bold></td><td align="center" valign="bottom" rowspan="1" colspan="1"></td><td align="center" valign="bottom" rowspan="1" colspan="1"></td><td align="center" valign="bottom" rowspan="1" colspan="1"></td><td align="center" valign="bottom" rowspan="1" colspan="1"></td><td align="center" valign="bottom" rowspan="1" colspan="1"></td><td align="center" valign="bottom" rowspan="1" colspan="1"></td></tr><tr><td colspan="16" align="left" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs1664789</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>WCadjBMI</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">5</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>ARL15</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">C</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.41</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.014</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.6E-05</td><td align="center" valign="bottom" rowspan="1" colspan="1">244,110</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.005</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.8E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">133,052</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.026</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>3.6E-08</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">109,025</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.4E-04</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs722585</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>HIPadjBMI</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">6</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>GMDS</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">G</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.68</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.015</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.1E-04</td><td align="center" valign="bottom" rowspan="1" colspan="1">205,815</td><td align="center" valign="bottom" rowspan="1" colspan="1">−0.001</td><td align="center" valign="bottom" rowspan="1" colspan="1">8.8E-01</td><td align="center" valign="bottom" rowspan="1" colspan="1">113,965</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.032</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>9.2E-09</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">89,831</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.3E-06</bold></td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs1144</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>WCadjBMI</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">7</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>SRPK2</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">C</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.34</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.019</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>3.1E-08</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">239,342</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.020</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.2E-05</td><td align="center" valign="bottom" rowspan="1" colspan="1">131,398</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.018</td><td align="center" valign="bottom" rowspan="1" colspan="1">4.1E-04</td><td align="center" valign="bottom" rowspan="1" colspan="1">105,911</td><td align="center" valign="bottom" rowspan="1" colspan="1">7.8E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs2398893</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>WHR</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">9</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>PTPDC1</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.71</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.020</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>4.0E-08</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">226,572</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.019</td><td align="center" valign="bottom" rowspan="1" colspan="1">5.1E-05</td><td align="center" valign="bottom" rowspan="1" colspan="1">124,577</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.019</td><td align="center" valign="bottom" rowspan="1" colspan="1">2.7E-04</td><td align="center" valign="bottom" rowspan="1" colspan="1">99,968</td><td align="center" valign="bottom" rowspan="1" colspan="1">9.5E-01</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1">rs4985155<sup><xref ref-type="table-fn" rid="TFN11">c</xref></sup></td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>HIP</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">16</td><td align="center" valign="bottom" rowspan="1" colspan="1"><italic>PDXDC1</italic></td><td align="center" valign="bottom" rowspan="1" colspan="1">A</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.66</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.018</td><td align="center" valign="bottom" rowspan="1" colspan="1">4.5E-07</td><td align="center" valign="bottom" rowspan="1" colspan="1">227,296</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.011</td><td align="center" valign="bottom" rowspan="1" colspan="1">1.6E-02</td><td align="center" valign="bottom" rowspan="1" colspan="1">125,048</td><td align="center" valign="bottom" rowspan="1" colspan="1">0.029</td><td align="center" valign="bottom" rowspan="1" colspan="1"><bold>9.7E-09</bold></td><td align="center" valign="bottom" rowspan="1" colspan="1">100,313</td><td align="center" valign="bottom" rowspan="1" colspan="1">6.3E-03</td></tr></tbody></table><table-wrap-foot><p><italic>P</italic> values and β coefficients for the association with the trait indicated in the meta-analysis of combined GWAS and Metabochip studies. The smallest <italic>P</italic> value for each SNP is shown in bold.</p><fn id="TFN9"><label>a</label><p id="P81">The effect allele is the trait-increasing allele in the sex-combined analysis.</p></fn><fn id="TFN10"><label>b</label><p id="P82">Test for sex difference; values significant at the table-wise Bonferroni threshold of 0.05/19=2.63×10<sup>−3</sup> are marked in bold.</p></fn><fn id="TFN11"><label>c</label><p id="P83"><italic>P</italic>=7.3×10<sup>−6</sup> with height in Okada <italic>et al</italic>.<sup><xref rid="R43" ref-type="bibr">43</xref></sup> (index SNP rs1136001; <italic>r</italic><sup>2</sup>=0.79, distance=2,515 bp). Chr, chromosome; EA, effect allele; EAF, effect allele frequency.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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