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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparison of 6q25 Breast Cancer Hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC)</title><author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name><affiliation><nlm:aff id="aff1"><addr-line>Unit of Genetic Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><addr-line>PMV (Primärmedizinische Versorgung) Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Maranian, Melanie" sort="Maranian, Melanie" uniqKey="Maranian M" first="Melanie" last="Maranian">Melanie Maranian</name><affiliation><nlm:aff id="aff3"><addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="aff4"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kapuscinski, Miroslaw K" sort="Kapuscinski, Miroslaw K" uniqKey="Kapuscinski M" first="Miroslaw K." last="Kapuscinski">Miroslaw K. Kapuscinski</name><affiliation><nlm:aff id="aff4"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="aff5"><addr-line>Department of Pathology, The University of Melbourne, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Park, Daniel J" sort="Park, Daniel J" uniqKey="Park D" first="Daniel J." last="Park">Daniel J. Park</name><affiliation><nlm:aff id="aff6"><addr-line>Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="aff7"><addr-line>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="aff7"><addr-line>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B. L." last="Hogervorst">Frans B. L. Hogervorst</name><affiliation><nlm:aff id="aff8"><addr-line>Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bueno De Mesquit, H Bas" sort="Bueno De Mesquit, H Bas" uniqKey="Bueno De Mesquit H" first="H. Bas" last="Bueno-De-Mesquit">H. Bas Bueno-De-Mesquit</name><affiliation><nlm:aff id="aff9"><addr-line>National Institute for Public Health and the Environment, Bilthoven, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth R" sort="Muir, Kenneth R" uniqKey="Muir K" first="Kenneth R." last="Muir">Kenneth R. Muir</name><affiliation><nlm:aff id="aff10"><addr-line>Health Sciences Research Institute, Warwick Medical School, Warwick University, Coventry, Warwick, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation><nlm:aff id="aff10"><addr-line>Health Sciences Research Institute, Warwick Medical School, Warwick University, Coventry, Warwick, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rattanamongkongul, Suthee" sort="Rattanamongkongul, Suthee" uniqKey="Rattanamongkongul S" first="Suthee" last="Rattanamongkongul">Suthee Rattanamongkongul</name><affiliation><nlm:aff id="aff11"><addr-line>Department of Preventive Medicine, Srinakhrainwirot University, Ongkharak, Nakhon Nayok, Thailand</addr-line></nlm:aff></affiliation></author><author><name sortKey="Puttawibul, Puttisak" sort="Puttawibul, Puttisak" uniqKey="Puttawibul P" first="Puttisak" last="Puttawibul">Puttisak Puttawibul</name><affiliation><nlm:aff id="aff12"><addr-line>Department of Surgery, Medical School, Prince Songkla University, Songkla, Thailand</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="aff13"><addr-line>University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff14"><addr-line>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hein, Alexander" sort="Hein, Alexander" uniqKey="Hein A" first="Alexander" last="Hein">Alexander Hein</name><affiliation><nlm:aff id="aff13"><addr-line>University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="aff15"><addr-line>Institute of Human Genetics, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="aff13"><addr-line>University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="aff16"><addr-line>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="aff16"><addr-line>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos Santos Silva">Isabel Dos Santos Silva</name><affiliation><nlm:aff id="aff17"><addr-line>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="aff17"><addr-line>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor" sort="Sawyer, Elinor" uniqKey="Sawyer E" first="Elinor" last="Sawyer">Elinor Sawyer</name><affiliation><nlm:aff id="aff18"><addr-line>Division of Cancer Studies, National Institute for Health Research Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ National Health Service Foundation Trust in partnership with King’s College London, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="aff19"><addr-line>Welcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff20"><addr-line>Oxford National Institute for Health Research Comprehensive Biomedical Research Centre, Oxford, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kerin, Michael" sort="Kerin, Michael" uniqKey="Kerin M" first="Michael" last="Kerin">Michael Kerin</name><affiliation><nlm:aff id="aff21"><addr-line>Clinical Science Institute. University Hospital Galway, Galway, Ireland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation><nlm:aff id="aff22"><addr-line>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Marmee, Frederick" sort="Marmee, Frederick" uniqKey="Marmee F" first="Frederick" last="Marmee">Frederick Marmee</name><affiliation><nlm:aff id="aff22"><addr-line>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff23"><addr-line>National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name><affiliation><nlm:aff id="aff22"><addr-line>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff23"><addr-line>National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name><affiliation><nlm:aff id="aff22"><addr-line>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="aff22"><addr-line>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff24"><addr-line>Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="aff25"><addr-line>Environmental Epidemiology of Cancer, U1018, CESP (Center for Research in Epidemiology and Population Health), Inserm (National Institute of Health and Medical Research), Villejuif, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff26"><addr-line>Unité mixte de recherche 1018, University Paris-Sud, Villejuif, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cordina Duverger, Emilie" sort="Cordina Duverger, Emilie" uniqKey="Cordina Duverger E" first="Emilie" last="Cordina-Duverger">Emilie Cordina-Duverger</name><affiliation><nlm:aff id="aff25"><addr-line>Environmental Epidemiology of Cancer, U1018, CESP (Center for Research in Epidemiology and Population Health), Inserm (National Institute of Health and Medical Research), Villejuif, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff26"><addr-line>Unité mixte de recherche 1018, University Paris-Sud, Villejuif, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name><affiliation><nlm:aff id="aff25"><addr-line>Environmental Epidemiology of Cancer, U1018, CESP (Center for Research in Epidemiology and Population Health), Inserm (National Institute of Health and Medical Research), Villejuif, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff26"><addr-line>Unité mixte de recherche 1018, University Paris-Sud, Villejuif, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="aff25"><addr-line>Environmental Epidemiology of Cancer, U1018, CESP (Center for Research in Epidemiology and Population Health), Inserm (National Institute of Health and Medical Research), Villejuif, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff26"><addr-line>Unité mixte de recherche 1018, University Paris-Sud, Villejuif, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="aff27"><addr-line>Copenhagen General Population Study and Department of Clinical Biochemistry, Herlev University Hospital, University of Copenhagen, Copenhagen, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="aff27"><addr-line>Copenhagen General Population Study and Department of Clinical Biochemistry, Herlev University Hospital, University of Copenhagen, Copenhagen, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="aff28"><addr-line>Department of Breast Surgery, Herlev University Hospital, University of Copenhagen, Copenhagen, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="aff29"><addr-line>Genetic & Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Perez, Jose Ignacio Arias" sort="Perez, Jose Ignacio Arias" uniqKey="Perez J" first="Jose Ignacio Arias" last="Perez">Jose Ignacio Arias Perez</name><affiliation><nlm:aff id="aff30"><addr-line>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M. Pilar" last="Zamora">M. Pilar Zamora</name><affiliation><nlm:aff id="aff31"><addr-line>Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name><affiliation><nlm:aff id="aff32"><addr-line>Cancer Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="aff33"><addr-line>Department of Epidemiology, University of California Irvine, Irvine, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name><affiliation><nlm:aff id="aff33"><addr-line>Department of Epidemiology, University of California Irvine, Irvine, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bernstein, Leslie" sort="Bernstein, Leslie" uniqKey="Bernstein L" first="Leslie" last="Bernstein">Leslie Bernstein</name><affiliation><nlm:aff id="aff34"><addr-line>Department of Population Sciences, City of Hope, Duarte, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Clarke, Christina A" sort="Clarke, Christina A" uniqKey="Clarke C" first="Christina A." last="Clarke">Christina A. Clarke</name><affiliation><nlm:aff id="aff35"><addr-line>Cancer Prevention Institute of California, Fremont, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="aff36"><addr-line>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Muller, Heiko" sort="Muller, Heiko" uniqKey="Muller H" first="Heiko" last="Müller">Heiko Müller</name><affiliation><nlm:aff id="aff36"><addr-line>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="aff36"><addr-line>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation><nlm:aff id="aff37"><addr-line>Saarland Cancer Registry, Saarbrücken, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation><nlm:aff id="aff38"><addr-line>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Seal, Sheila" sort="Seal, Sheila" uniqKey="Seal S" first="Sheila" last="Seal">Sheila Seal</name><affiliation><nlm:aff id="aff38"><addr-line>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name><affiliation><nlm:aff id="aff38"><addr-line>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Renwick, Anthony" sort="Renwick, Anthony" uniqKey="Renwick A" first="Anthony" last="Renwick">Anthony Renwick</name><affiliation><nlm:aff id="aff38"><addr-line>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="aff39"><addr-line>Division of Gynecology and Obstetrics, Klinikum rechts der Isar at the Technical University Munich, Munich, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Schott, Sarah" sort="Schott, Sarah" uniqKey="Schott S" first="Sarah" last="Schott">Sarah Schott</name><affiliation><nlm:aff id="aff40"><addr-line>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bartram, Claus R" sort="Bartram, Claus R" uniqKey="Bartram C" first="Claus R." last="Bartram">Claus R. Bartram</name><affiliation><nlm:aff id="aff41"><addr-line>Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="aff42"><addr-line>Center for Familial Breast and Ovarian Cancer and Center of Integrated Oncology (CIO), University Hospital, Cologne, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="aff43"><addr-line>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, University of Tübingen, Tübingen, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="aff44"><addr-line>Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name><affiliation><nlm:aff id="aff45"><addr-line>Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name><affiliation><nlm:aff id="aff48"><addr-line>Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="aff49"><addr-line>Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Schurmann, Peter" sort="Schurmann, Peter" uniqKey="Schurmann P" first="Peter" last="Schürmann">Peter Schürmann</name><affiliation><nlm:aff id="aff49"><addr-line>Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Karstens, Johann H" sort="Karstens, Johann H" uniqKey="Karstens J" first="Johann H." last="Karstens">Johann H. Karstens</name><affiliation><nlm:aff id="aff50"><addr-line>Clinics of Radiation Oncology, Hannover Medical School, Hannover, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hillemanns, Peter" sort="Hillemanns, Peter" uniqKey="Hillemanns P" first="Peter" last="Hillemanns">Peter Hillemanns</name><affiliation><nlm:aff id="aff49"><addr-line>Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="aff51"><addr-line>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Heikkinen, Tuomas" sort="Heikkinen, Tuomas" uniqKey="Heikkinen T" first="Tuomas" last="Heikkinen">Tuomas Heikkinen</name><affiliation><nlm:aff id="aff51"><addr-line>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="aff52"><addr-line>Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="aff53"><addr-line>Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation><nlm:aff id="aff54"><addr-line>Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany, Clinics of Radiation Oncology, Hannover Medical School, Hannover, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zalutsky, Iosif V" sort="Zalutsky, Iosif V" uniqKey="Zalutsky I" first="Iosif V." last="Zalutsky">Iosif V. Zalutsky</name><affiliation><nlm:aff id="aff55"><addr-line>N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus</addr-line></nlm:aff></affiliation></author><author><name sortKey="Antonenkova, Natalia N" sort="Antonenkova, Natalia N" uniqKey="Antonenkova N" first="Natalia N." last="Antonenkova">Natalia N. Antonenkova</name><affiliation><nlm:aff id="aff55"><addr-line>N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bermisheva, Marina" sort="Bermisheva, Marina" uniqKey="Bermisheva M" first="Marina" last="Bermisheva">Marina Bermisheva</name><affiliation><nlm:aff id="aff56"><addr-line>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Prokovieva, Darya" sort="Prokovieva, Darya" uniqKey="Prokovieva D" first="Darya" last="Prokovieva">Darya Prokovieva</name><affiliation><nlm:aff id="aff56"><addr-line>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Farahtdinova, Albina" sort="Farahtdinova, Albina" uniqKey="Farahtdinova A" first="Albina" last="Farahtdinova">Albina Farahtdinova</name><affiliation><nlm:aff id="aff56"><addr-line>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Khusnutdinova, Elza" sort="Khusnutdinova, Elza" uniqKey="Khusnutdinova E" first="Elza" last="Khusnutdinova">Elza Khusnutdinova</name><affiliation><nlm:aff id="aff56"><addr-line>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="aff57"><addr-line>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="aff58"><addr-line>Department of Oncology Pathology, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="aff58"><addr-line>Department of Oncology Pathology, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff50"><addr-line>Clinics of Radiation Oncology, Hannover Medical School, Hannover, Germany</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff60"><addr-line>Biocenter Kuopio, Kuopio University Hospital, Kuopio, Finland</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff61"><addr-line>Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation><nlm:aff id="aff60"><addr-line>Biocenter Kuopio, Kuopio University Hospital, Kuopio, Finland</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff62"><addr-line>School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, Kuopio, Finland</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff63"><addr-line>Department of Oncology, Kuopio University Hospital, Kuopio, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="aff59"><addr-line>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff60"><addr-line>Biocenter Kuopio, Kuopio University Hospital, Kuopio, Finland</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff61"><addr-line>Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Jaana" sort="Hartikainen, Jaana" uniqKey="Hartikainen J" first="Jaana" last="Hartikainen">Jaana Hartikainen</name><affiliation><nlm:aff id="aff59"><addr-line>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff60"><addr-line>Biocenter Kuopio, Kuopio University Hospital, Kuopio, Finland</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff61"><addr-line>Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name><affiliation><nlm:aff id="aff64"><addr-line>Cancer Division, Queensland Institute of Medical Research, Brisbane, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="aff64"><addr-line>Cancer Division, Queensland Institute of Medical Research, Brisbane, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Investigators, Kconfab" sort="Investigators, Kconfab" uniqKey="Investigators K" first="Kconfab" last="Investigators">Kconfab Investigators</name><affiliation><nlm:aff id="aff65"><addr-line>Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer [kConFab], Peter MacCallum Cancer Center, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="aff67"><addr-line>Vesalius Research Center (VRC), Vesalius Research Center, Leuven, Belgium; Vesalius Research Center (VRC), Katholieke Universiteit (KU) Leuven, Leuven, Belgium</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zhao, Hui" sort="Zhao, Hui" uniqKey="Zhao H" first="Hui" last="Zhao">Hui Zhao</name><affiliation><nlm:aff id="aff67"><addr-line>Vesalius Research Center (VRC), Vesalius Research Center, Leuven, Belgium; Vesalius Research Center (VRC), Katholieke Universiteit (KU) Leuven, Leuven, Belgium</addr-line></nlm:aff></affiliation></author><author><name sortKey="Neven, Patrick" sort="Neven, Patrick" uniqKey="Neven P" first="Patrick" last="Neven">Patrick Neven</name><affiliation><nlm:aff id="aff68"><addr-line>Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wildiers, Hans" sort="Wildiers, Hans" uniqKey="Wildiers H" first="Hans" last="Wildiers">Hans Wildiers</name><affiliation><nlm:aff id="aff68"><addr-line>Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nickels, Stefan" sort="Nickels, Stefan" uniqKey="Nickels S" first="Stefan" last="Nickels">Stefan Nickels</name><affiliation><nlm:aff id="aff1"><addr-line>Unit of Genetic Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="aff69"><addr-line>Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="aff70"><addr-line>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff71"><addr-line>Fondazione Istituto FIRC (Fondazione Italiana per la Ricerca sul Cancro) Di Oncologia Molecolare (IFOM), Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="aff70"><addr-line>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff71"><addr-line>Fondazione Istituto FIRC (Fondazione Italiana per la Ricerca sul Cancro) Di Oncologia Molecolare (IFOM), Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="aff72"><addr-line>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione Instituto di Recuvero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale Tumori (INT), Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Barile, Monica" sort="Barile, Monica" uniqKey="Barile M" first="Monica" last="Barile">Monica Barile</name><affiliation><nlm:aff id="aff73"><addr-line>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="aff74"><addr-line>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="aff74"><addr-line>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff id="aff75"><addr-line>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fredericksen, Zachary" sort="Fredericksen, Zachary" uniqKey="Fredericksen Z" first="Zachary" last="Fredericksen">Zachary Fredericksen</name><affiliation><nlm:aff id="aff74"><addr-line>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="aff76"><addr-line>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff77"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:aff id="aff76"><addr-line>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff77"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona A" sort="Mclean, Catriona A" uniqKey="Mclean C" first="Catriona A." last="Mclean">Catriona A. Mclean</name><affiliation><nlm:aff id="aff78"><addr-line>Department of Anatomical Pathology, The Alfred Hospital, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="aff76"><addr-line>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff77"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><nlm:aff id="aff79"><addr-line>Clinical Genetics Service, Dept. of Medicine and Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Robson, Mark" sort="Robson, Mark" uniqKey="Robson M" first="Mark" last="Robson">Mark Robson</name><affiliation><nlm:aff id="aff80"><addr-line>Clinical Genetics Service, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M." last="Gaudet">Mia M. Gaudet</name><affiliation><nlm:aff id="aff81"><addr-line>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name><affiliation><nlm:aff id="aff79"><addr-line>Clinical Genetics Service, Dept. of Medicine and Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Aln S, Grethe Grenaker" sort="Aln S, Grethe Grenaker" uniqKey="Aln S G" first="Grethe Grenaker" last="Aln S">Grethe Grenaker Aln S</name><affiliation><nlm:aff id="aff82"><addr-line>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation><nlm:aff id="aff82"><addr-line>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff83"><addr-line>Faculty of Medicine (Faculty Division Ahus), University of Oslo, Oslo, Norway</addr-line></nlm:aff></affiliation></author><author><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name><affiliation><nlm:aff id="aff82"><addr-line>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff83"><addr-line>Faculty of Medicine (Faculty Division Ahus), University of Oslo, Oslo, Norway</addr-line></nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name><affiliation><nlm:aff id="aff84"><addr-line>Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, United States of America</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff85"><addr-line>Stanford University School of Medicine, Stanford, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Miron, Alexander" sort="Miron, Alexander" uniqKey="Miron A" first="Alexander" last="Miron">Alexander Miron</name><affiliation><nlm:aff id="aff86"><addr-line>Deptartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="aff87"><addr-line>Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="aff87"><addr-line>Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation><nlm:aff id="aff88"><addr-line>Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Grip, Mervi" sort="Grip, Mervi" uniqKey="Grip M" first="Mervi" last="Grip">Mervi Grip</name><affiliation><nlm:aff id="aff89"><addr-line>Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="aff90"><addr-line>Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff91"><addr-line>Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff92"><addr-line>Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="aff93"><addr-line>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff94"><addr-line>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="aff90"><addr-line>Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="aff95"><addr-line>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff96"><addr-line>Department of Laboratory Medicine, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D." last="Figueroa">Jonine D. Figueroa</name><affiliation><nlm:aff id="aff97"><addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="aff97"><addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff98"><addr-line>Sections of Epidemiology and Genetics, Institute of Cancer Research and Breakthrough Breast Cancer Research Centre, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation><nlm:aff id="aff99"><addr-line>Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw, Poland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sherman, Mark E" sort="Sherman, Mark E" uniqKey="Sherman M" first="Mark E." last="Sherman">Mark E. Sherman</name><affiliation><nlm:aff id="aff97"><addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje" sort="Hooning, Maartje" uniqKey="Hooning M" first="Maartje" last="Hooning">Maartje Hooning</name><affiliation><nlm:aff id="aff100"><addr-line>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Martens, John W M" sort="Martens, John W M" uniqKey="Martens J" first="John W. M." last="Martens">John W. M. Martens</name><affiliation><nlm:aff id="aff101"><addr-line>Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation><nlm:aff id="aff100"><addr-line>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Collee, Margriet" sort="Collee, Margriet" uniqKey="Collee M" first="Margriet" last="Collée">Margriet Collée</name><affiliation><nlm:aff id="aff102"><addr-line>Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="aff103"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Humpreys, Keith" sort="Humpreys, Keith" uniqKey="Humpreys K" first="Keith" last="Humpreys">Keith Humpreys</name><affiliation><nlm:aff id="aff103"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="aff103"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:aff id="aff104"><addr-line>Population Genetics, Genome Institute of Singapore, Singapore, Republic of Singapore</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="aff105"><addr-line>Institute for Cancer Studies, Department of Oncology, University of Sheffield, Sheffield, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Brock, Ian W" sort="Brock, Ian W" uniqKey="Brock I" first="Ian W." last="Brock">Ian W. Brock</name><affiliation><nlm:aff id="aff105"><addr-line>Institute for Cancer Studies, Department of Oncology, University of Sheffield, Sheffield, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="aff106"><addr-line>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name><affiliation><nlm:aff id="aff107"><addr-line>Academic Unit of Surgical Oncology, Department of Oncology, University of Sheffield, Sheffield, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ahmed, Shahana" sort="Ahmed, Shahana" uniqKey="Ahmed S" first="Shahana" last="Ahmed">Shahana Ahmed</name><affiliation><nlm:aff id="aff3"><addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name><affiliation><nlm:aff id="aff3"><addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul Dp" sort="Pharoah, Paul Dp" uniqKey="Pharoah P" first="Paul Dp." last="Pharoah">Paul Dp. Pharoah</name><affiliation><nlm:aff id="aff3"><addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff108"><addr-line>Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation><nlm:aff id="aff109"><addr-line>Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</addr-line></nlm:aff></affiliation></author><author><name sortKey="Yoo, Keun Young" sort="Yoo, Keun Young" uniqKey="Yoo K" first="Keun-Young" last="Yoo">Keun-Young Yoo</name><affiliation><nlm:aff id="aff109"><addr-line>Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</addr-line></nlm:aff></affiliation></author><author><name sortKey="Noh, Dong Young" sort="Noh, Dong Young" uniqKey="Noh D" first="Dong-Young" last="Noh">Dong-Young Noh</name><affiliation><nlm:aff id="aff110"><addr-line>Department of Surgery, Seoul National University College of Medicine, Seoul, Korea</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="aff111"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jaworska, Katarzyna" sort="Jaworska, Katarzyna" uniqKey="Jaworska K" first="Katarzyna" last="Jaworska">Katarzyna Jaworska</name><affiliation><nlm:aff id="aff111"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff112"><addr-line>Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="aff111"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zlowocka, El Bieta" sort="Zlowocka, El Bieta" uniqKey="Zlowocka E" first="El Bieta" last="Złowocka">El Bieta Złowocka</name><affiliation><nlm:aff id="aff111"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name><affiliation><nlm:aff id="aff113"><addr-line>Molecular Epidemiology Unit, National Cancer Institute, Bangkok, Thailand</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gaborieau, Valerie" sort="Gaborieau, Valerie" uniqKey="Gaborieau V" first="Valerie" last="Gaborieau">Valerie Gaborieau</name><affiliation><nlm:aff id="aff114"><addr-line>Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:aff id="aff114"><addr-line>Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name><affiliation><nlm:aff id="aff114"><addr-line>Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name><affiliation><nlm:aff id="aff115"><addr-line>Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff116"><addr-line>Taiwan Biobank, Taipei, Taiwan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Yu, Jyh Cherng" sort="Yu, Jyh Cherng" uniqKey="Yu J" first="Jyh-Cherng" last="Yu">Jyh-Cherng Yu</name><affiliation><nlm:aff id="aff117"><addr-line>Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hsu, Huan Ming" sort="Hsu, Huan Ming" uniqKey="Hsu H" first="Huan-Ming" last="Hsu">Huan-Ming Hsu</name><affiliation><nlm:aff id="aff117"><addr-line>Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hou, Ming Feng" sort="Hou, Ming Feng" uniqKey="Hou M" first="Ming-Feng" last="Hou">Ming-Feng Hou</name><affiliation><nlm:aff id="aff118"><addr-line>Cancer Center and Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation><nlm:aff id="aff119"><addr-line>The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Schoemaker, Minouk" sort="Schoemaker, Minouk" uniqKey="Schoemaker M" first="Minouk" last="Schoemaker">Minouk Schoemaker</name><affiliation><nlm:aff id="aff120"><addr-line>Section of Epidemiology, Institute of Cancer Research, Sutton, Surrey, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation><nlm:aff id="aff119"><addr-line>The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="aff120"><addr-line>Section of Epidemiology, Institute of Cancer Research, Sutton, Surrey, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Trentham Dietz, Amy" sort="Trentham Dietz, Amy" uniqKey="Trentham Dietz A" first="Amy" last="Trentham-Dietz">Amy Trentham-Dietz</name><affiliation><nlm:aff id="aff121"><addr-line>University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A." last="Newcomb">Polly A. Newcomb</name><affiliation><nlm:aff id="aff121"><addr-line>University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, United States of America</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff122"><addr-line>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Titus, Linda" sort="Titus, Linda" uniqKey="Titus L" first="Linda" last="Titus">Linda Titus</name><affiliation><nlm:aff id="aff123"><addr-line>Department of Community & Family Medicine, Department of Pediatrics, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, New Hampshire, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Egan, Kathleen M" sort="Egan, Kathleen M" uniqKey="Egan K" first="Kathleen M." last="Egan">Kathleen M. Egan</name><affiliation><nlm:aff id="aff124"><addr-line>Division of Population Sciences, Moffitt Cancer Center & Research Institute, Tampa, Florida, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="aff64"><addr-line>Cancer Division, Queensland Institute of Medical Research, Brisbane, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name><affiliation><nlm:aff id="aff108"><addr-line>Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Humphreys, Manjeet K" sort="Humphreys, Manjeet K" uniqKey="Humphreys M" first="Manjeet K." last="Humphreys">Manjeet K. Humphreys</name><affiliation><nlm:aff id="aff108"><addr-line>Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Morrison, Jonathan" sort="Morrison, Jonathan" uniqKey="Morrison J" first="Jonathan" last="Morrison">Jonathan Morrison</name><affiliation><nlm:aff id="aff108"><addr-line>Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="aff1"><addr-line>Unit of Genetic Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="aff108"><addr-line>Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="aff3"><addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22879957</idno><idno type="pmc">3413660</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413660</idno><idno type="RBID">PMC:3413660</idno><idno type="doi">10.1371/journal.pone.0042380</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002A32</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002A32</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparison of 6q25 Breast Cancer Hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC)</title><author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name><affiliation><nlm:aff id="aff1"><addr-line>Unit of Genetic Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><addr-line>PMV (Primärmedizinische Versorgung) Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Maranian, Melanie" sort="Maranian, Melanie" uniqKey="Maranian M" first="Melanie" last="Maranian">Melanie Maranian</name><affiliation><nlm:aff id="aff3"><addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="aff4"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kapuscinski, Miroslaw K" sort="Kapuscinski, Miroslaw K" uniqKey="Kapuscinski M" first="Miroslaw K." last="Kapuscinski">Miroslaw K. Kapuscinski</name><affiliation><nlm:aff id="aff4"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="aff5"><addr-line>Department of Pathology, The University of Melbourne, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Park, Daniel J" sort="Park, Daniel J" uniqKey="Park D" first="Daniel J." last="Park">Daniel J. Park</name><affiliation><nlm:aff id="aff6"><addr-line>Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="aff7"><addr-line>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="aff7"><addr-line>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B. L." last="Hogervorst">Frans B. L. Hogervorst</name><affiliation><nlm:aff id="aff8"><addr-line>Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bueno De Mesquit, H Bas" sort="Bueno De Mesquit, H Bas" uniqKey="Bueno De Mesquit H" first="H. Bas" last="Bueno-De-Mesquit">H. Bas Bueno-De-Mesquit</name><affiliation><nlm:aff id="aff9"><addr-line>National Institute for Public Health and the Environment, Bilthoven, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth R" sort="Muir, Kenneth R" uniqKey="Muir K" first="Kenneth R." last="Muir">Kenneth R. Muir</name><affiliation><nlm:aff id="aff10"><addr-line>Health Sciences Research Institute, Warwick Medical School, Warwick University, Coventry, Warwick, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation><nlm:aff id="aff10"><addr-line>Health Sciences Research Institute, Warwick Medical School, Warwick University, Coventry, Warwick, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rattanamongkongul, Suthee" sort="Rattanamongkongul, Suthee" uniqKey="Rattanamongkongul S" first="Suthee" last="Rattanamongkongul">Suthee Rattanamongkongul</name><affiliation><nlm:aff id="aff11"><addr-line>Department of Preventive Medicine, Srinakhrainwirot University, Ongkharak, Nakhon Nayok, Thailand</addr-line></nlm:aff></affiliation></author><author><name sortKey="Puttawibul, Puttisak" sort="Puttawibul, Puttisak" uniqKey="Puttawibul P" first="Puttisak" last="Puttawibul">Puttisak Puttawibul</name><affiliation><nlm:aff id="aff12"><addr-line>Department of Surgery, Medical School, Prince Songkla University, Songkla, Thailand</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="aff13"><addr-line>University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff14"><addr-line>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hein, Alexander" sort="Hein, Alexander" uniqKey="Hein A" first="Alexander" last="Hein">Alexander Hein</name><affiliation><nlm:aff id="aff13"><addr-line>University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="aff15"><addr-line>Institute of Human Genetics, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="aff13"><addr-line>University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="aff16"><addr-line>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="aff16"><addr-line>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos Santos Silva">Isabel Dos Santos Silva</name><affiliation><nlm:aff id="aff17"><addr-line>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="aff17"><addr-line>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor" sort="Sawyer, Elinor" uniqKey="Sawyer E" first="Elinor" last="Sawyer">Elinor Sawyer</name><affiliation><nlm:aff id="aff18"><addr-line>Division of Cancer Studies, National Institute for Health Research Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ National Health Service Foundation Trust in partnership with King’s College London, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="aff19"><addr-line>Welcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff20"><addr-line>Oxford National Institute for Health Research Comprehensive Biomedical Research Centre, Oxford, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kerin, Michael" sort="Kerin, Michael" uniqKey="Kerin M" first="Michael" last="Kerin">Michael Kerin</name><affiliation><nlm:aff id="aff21"><addr-line>Clinical Science Institute. University Hospital Galway, Galway, Ireland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation><nlm:aff id="aff22"><addr-line>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Marmee, Frederick" sort="Marmee, Frederick" uniqKey="Marmee F" first="Frederick" last="Marmee">Frederick Marmee</name><affiliation><nlm:aff id="aff22"><addr-line>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff23"><addr-line>National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name><affiliation><nlm:aff id="aff22"><addr-line>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff23"><addr-line>National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name><affiliation><nlm:aff id="aff22"><addr-line>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="aff22"><addr-line>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff24"><addr-line>Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="aff25"><addr-line>Environmental Epidemiology of Cancer, U1018, CESP (Center for Research in Epidemiology and Population Health), Inserm (National Institute of Health and Medical Research), Villejuif, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff26"><addr-line>Unité mixte de recherche 1018, University Paris-Sud, Villejuif, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cordina Duverger, Emilie" sort="Cordina Duverger, Emilie" uniqKey="Cordina Duverger E" first="Emilie" last="Cordina-Duverger">Emilie Cordina-Duverger</name><affiliation><nlm:aff id="aff25"><addr-line>Environmental Epidemiology of Cancer, U1018, CESP (Center for Research in Epidemiology and Population Health), Inserm (National Institute of Health and Medical Research), Villejuif, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff26"><addr-line>Unité mixte de recherche 1018, University Paris-Sud, Villejuif, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name><affiliation><nlm:aff id="aff25"><addr-line>Environmental Epidemiology of Cancer, U1018, CESP (Center for Research in Epidemiology and Population Health), Inserm (National Institute of Health and Medical Research), Villejuif, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff26"><addr-line>Unité mixte de recherche 1018, University Paris-Sud, Villejuif, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="aff25"><addr-line>Environmental Epidemiology of Cancer, U1018, CESP (Center for Research in Epidemiology and Population Health), Inserm (National Institute of Health and Medical Research), Villejuif, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff26"><addr-line>Unité mixte de recherche 1018, University Paris-Sud, Villejuif, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="aff27"><addr-line>Copenhagen General Population Study and Department of Clinical Biochemistry, Herlev University Hospital, University of Copenhagen, Copenhagen, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="aff27"><addr-line>Copenhagen General Population Study and Department of Clinical Biochemistry, Herlev University Hospital, University of Copenhagen, Copenhagen, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="aff28"><addr-line>Department of Breast Surgery, Herlev University Hospital, University of Copenhagen, Copenhagen, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="aff29"><addr-line>Genetic & Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Perez, Jose Ignacio Arias" sort="Perez, Jose Ignacio Arias" uniqKey="Perez J" first="Jose Ignacio Arias" last="Perez">Jose Ignacio Arias Perez</name><affiliation><nlm:aff id="aff30"><addr-line>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M. Pilar" last="Zamora">M. Pilar Zamora</name><affiliation><nlm:aff id="aff31"><addr-line>Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name><affiliation><nlm:aff id="aff32"><addr-line>Cancer Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="aff33"><addr-line>Department of Epidemiology, University of California Irvine, Irvine, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name><affiliation><nlm:aff id="aff33"><addr-line>Department of Epidemiology, University of California Irvine, Irvine, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bernstein, Leslie" sort="Bernstein, Leslie" uniqKey="Bernstein L" first="Leslie" last="Bernstein">Leslie Bernstein</name><affiliation><nlm:aff id="aff34"><addr-line>Department of Population Sciences, City of Hope, Duarte, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Clarke, Christina A" sort="Clarke, Christina A" uniqKey="Clarke C" first="Christina A." last="Clarke">Christina A. Clarke</name><affiliation><nlm:aff id="aff35"><addr-line>Cancer Prevention Institute of California, Fremont, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="aff36"><addr-line>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Muller, Heiko" sort="Muller, Heiko" uniqKey="Muller H" first="Heiko" last="Müller">Heiko Müller</name><affiliation><nlm:aff id="aff36"><addr-line>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="aff36"><addr-line>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation><nlm:aff id="aff37"><addr-line>Saarland Cancer Registry, Saarbrücken, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation><nlm:aff id="aff38"><addr-line>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Seal, Sheila" sort="Seal, Sheila" uniqKey="Seal S" first="Sheila" last="Seal">Sheila Seal</name><affiliation><nlm:aff id="aff38"><addr-line>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name><affiliation><nlm:aff id="aff38"><addr-line>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Renwick, Anthony" sort="Renwick, Anthony" uniqKey="Renwick A" first="Anthony" last="Renwick">Anthony Renwick</name><affiliation><nlm:aff id="aff38"><addr-line>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="aff39"><addr-line>Division of Gynecology and Obstetrics, Klinikum rechts der Isar at the Technical University Munich, Munich, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Schott, Sarah" sort="Schott, Sarah" uniqKey="Schott S" first="Sarah" last="Schott">Sarah Schott</name><affiliation><nlm:aff id="aff40"><addr-line>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bartram, Claus R" sort="Bartram, Claus R" uniqKey="Bartram C" first="Claus R." last="Bartram">Claus R. Bartram</name><affiliation><nlm:aff id="aff41"><addr-line>Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="aff42"><addr-line>Center for Familial Breast and Ovarian Cancer and Center of Integrated Oncology (CIO), University Hospital, Cologne, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="aff43"><addr-line>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, University of Tübingen, Tübingen, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="aff44"><addr-line>Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name><affiliation><nlm:aff id="aff45"><addr-line>Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name><affiliation><nlm:aff id="aff48"><addr-line>Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="aff49"><addr-line>Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Schurmann, Peter" sort="Schurmann, Peter" uniqKey="Schurmann P" first="Peter" last="Schürmann">Peter Schürmann</name><affiliation><nlm:aff id="aff49"><addr-line>Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Karstens, Johann H" sort="Karstens, Johann H" uniqKey="Karstens J" first="Johann H." last="Karstens">Johann H. Karstens</name><affiliation><nlm:aff id="aff50"><addr-line>Clinics of Radiation Oncology, Hannover Medical School, Hannover, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hillemanns, Peter" sort="Hillemanns, Peter" uniqKey="Hillemanns P" first="Peter" last="Hillemanns">Peter Hillemanns</name><affiliation><nlm:aff id="aff49"><addr-line>Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="aff51"><addr-line>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Heikkinen, Tuomas" sort="Heikkinen, Tuomas" uniqKey="Heikkinen T" first="Tuomas" last="Heikkinen">Tuomas Heikkinen</name><affiliation><nlm:aff id="aff51"><addr-line>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="aff52"><addr-line>Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="aff53"><addr-line>Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation><nlm:aff id="aff54"><addr-line>Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany, Clinics of Radiation Oncology, Hannover Medical School, Hannover, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zalutsky, Iosif V" sort="Zalutsky, Iosif V" uniqKey="Zalutsky I" first="Iosif V." last="Zalutsky">Iosif V. Zalutsky</name><affiliation><nlm:aff id="aff55"><addr-line>N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus</addr-line></nlm:aff></affiliation></author><author><name sortKey="Antonenkova, Natalia N" sort="Antonenkova, Natalia N" uniqKey="Antonenkova N" first="Natalia N." last="Antonenkova">Natalia N. Antonenkova</name><affiliation><nlm:aff id="aff55"><addr-line>N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bermisheva, Marina" sort="Bermisheva, Marina" uniqKey="Bermisheva M" first="Marina" last="Bermisheva">Marina Bermisheva</name><affiliation><nlm:aff id="aff56"><addr-line>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Prokovieva, Darya" sort="Prokovieva, Darya" uniqKey="Prokovieva D" first="Darya" last="Prokovieva">Darya Prokovieva</name><affiliation><nlm:aff id="aff56"><addr-line>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Farahtdinova, Albina" sort="Farahtdinova, Albina" uniqKey="Farahtdinova A" first="Albina" last="Farahtdinova">Albina Farahtdinova</name><affiliation><nlm:aff id="aff56"><addr-line>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Khusnutdinova, Elza" sort="Khusnutdinova, Elza" uniqKey="Khusnutdinova E" first="Elza" last="Khusnutdinova">Elza Khusnutdinova</name><affiliation><nlm:aff id="aff56"><addr-line>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="aff57"><addr-line>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="aff58"><addr-line>Department of Oncology Pathology, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="aff58"><addr-line>Department of Oncology Pathology, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff50"><addr-line>Clinics of Radiation Oncology, Hannover Medical School, Hannover, Germany</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff60"><addr-line>Biocenter Kuopio, Kuopio University Hospital, Kuopio, Finland</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff61"><addr-line>Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation><nlm:aff id="aff60"><addr-line>Biocenter Kuopio, Kuopio University Hospital, Kuopio, Finland</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff62"><addr-line>School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, Kuopio, Finland</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff63"><addr-line>Department of Oncology, Kuopio University Hospital, Kuopio, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="aff59"><addr-line>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff60"><addr-line>Biocenter Kuopio, Kuopio University Hospital, Kuopio, Finland</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff61"><addr-line>Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Jaana" sort="Hartikainen, Jaana" uniqKey="Hartikainen J" first="Jaana" last="Hartikainen">Jaana Hartikainen</name><affiliation><nlm:aff id="aff59"><addr-line>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff60"><addr-line>Biocenter Kuopio, Kuopio University Hospital, Kuopio, Finland</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff61"><addr-line>Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name><affiliation><nlm:aff id="aff64"><addr-line>Cancer Division, Queensland Institute of Medical Research, Brisbane, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="aff64"><addr-line>Cancer Division, Queensland Institute of Medical Research, Brisbane, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Investigators, Kconfab" sort="Investigators, Kconfab" uniqKey="Investigators K" first="Kconfab" last="Investigators">Kconfab Investigators</name><affiliation><nlm:aff id="aff65"><addr-line>Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer [kConFab], Peter MacCallum Cancer Center, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="aff67"><addr-line>Vesalius Research Center (VRC), Vesalius Research Center, Leuven, Belgium; Vesalius Research Center (VRC), Katholieke Universiteit (KU) Leuven, Leuven, Belgium</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zhao, Hui" sort="Zhao, Hui" uniqKey="Zhao H" first="Hui" last="Zhao">Hui Zhao</name><affiliation><nlm:aff id="aff67"><addr-line>Vesalius Research Center (VRC), Vesalius Research Center, Leuven, Belgium; Vesalius Research Center (VRC), Katholieke Universiteit (KU) Leuven, Leuven, Belgium</addr-line></nlm:aff></affiliation></author><author><name sortKey="Neven, Patrick" sort="Neven, Patrick" uniqKey="Neven P" first="Patrick" last="Neven">Patrick Neven</name><affiliation><nlm:aff id="aff68"><addr-line>Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wildiers, Hans" sort="Wildiers, Hans" uniqKey="Wildiers H" first="Hans" last="Wildiers">Hans Wildiers</name><affiliation><nlm:aff id="aff68"><addr-line>Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nickels, Stefan" sort="Nickels, Stefan" uniqKey="Nickels S" first="Stefan" last="Nickels">Stefan Nickels</name><affiliation><nlm:aff id="aff1"><addr-line>Unit of Genetic Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="aff69"><addr-line>Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="aff70"><addr-line>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff71"><addr-line>Fondazione Istituto FIRC (Fondazione Italiana per la Ricerca sul Cancro) Di Oncologia Molecolare (IFOM), Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="aff70"><addr-line>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff71"><addr-line>Fondazione Istituto FIRC (Fondazione Italiana per la Ricerca sul Cancro) Di Oncologia Molecolare (IFOM), Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="aff72"><addr-line>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione Instituto di Recuvero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale Tumori (INT), Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Barile, Monica" sort="Barile, Monica" uniqKey="Barile M" first="Monica" last="Barile">Monica Barile</name><affiliation><nlm:aff id="aff73"><addr-line>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="aff74"><addr-line>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="aff74"><addr-line>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff id="aff75"><addr-line>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fredericksen, Zachary" sort="Fredericksen, Zachary" uniqKey="Fredericksen Z" first="Zachary" last="Fredericksen">Zachary Fredericksen</name><affiliation><nlm:aff id="aff74"><addr-line>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="aff76"><addr-line>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff77"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:aff id="aff76"><addr-line>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff77"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona A" sort="Mclean, Catriona A" uniqKey="Mclean C" first="Catriona A." last="Mclean">Catriona A. Mclean</name><affiliation><nlm:aff id="aff78"><addr-line>Department of Anatomical Pathology, The Alfred Hospital, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="aff76"><addr-line>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff77"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><nlm:aff id="aff79"><addr-line>Clinical Genetics Service, Dept. of Medicine and Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Robson, Mark" sort="Robson, Mark" uniqKey="Robson M" first="Mark" last="Robson">Mark Robson</name><affiliation><nlm:aff id="aff80"><addr-line>Clinical Genetics Service, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M." last="Gaudet">Mia M. Gaudet</name><affiliation><nlm:aff id="aff81"><addr-line>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name><affiliation><nlm:aff id="aff79"><addr-line>Clinical Genetics Service, Dept. of Medicine and Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Aln S, Grethe Grenaker" sort="Aln S, Grethe Grenaker" uniqKey="Aln S G" first="Grethe Grenaker" last="Aln S">Grethe Grenaker Aln S</name><affiliation><nlm:aff id="aff82"><addr-line>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation><nlm:aff id="aff82"><addr-line>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff83"><addr-line>Faculty of Medicine (Faculty Division Ahus), University of Oslo, Oslo, Norway</addr-line></nlm:aff></affiliation></author><author><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name><affiliation><nlm:aff id="aff82"><addr-line>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff83"><addr-line>Faculty of Medicine (Faculty Division Ahus), University of Oslo, Oslo, Norway</addr-line></nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name><affiliation><nlm:aff id="aff84"><addr-line>Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, United States of America</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff85"><addr-line>Stanford University School of Medicine, Stanford, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Miron, Alexander" sort="Miron, Alexander" uniqKey="Miron A" first="Alexander" last="Miron">Alexander Miron</name><affiliation><nlm:aff id="aff86"><addr-line>Deptartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="aff87"><addr-line>Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="aff87"><addr-line>Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation><nlm:aff id="aff88"><addr-line>Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Grip, Mervi" sort="Grip, Mervi" uniqKey="Grip M" first="Mervi" last="Grip">Mervi Grip</name><affiliation><nlm:aff id="aff89"><addr-line>Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="aff90"><addr-line>Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff91"><addr-line>Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff92"><addr-line>Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="aff93"><addr-line>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff94"><addr-line>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="aff90"><addr-line>Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="aff95"><addr-line>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff96"><addr-line>Department of Laboratory Medicine, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D." last="Figueroa">Jonine D. Figueroa</name><affiliation><nlm:aff id="aff97"><addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="aff97"><addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff98"><addr-line>Sections of Epidemiology and Genetics, Institute of Cancer Research and Breakthrough Breast Cancer Research Centre, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation><nlm:aff id="aff99"><addr-line>Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw, Poland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sherman, Mark E" sort="Sherman, Mark E" uniqKey="Sherman M" first="Mark E." last="Sherman">Mark E. Sherman</name><affiliation><nlm:aff id="aff97"><addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje" sort="Hooning, Maartje" uniqKey="Hooning M" first="Maartje" last="Hooning">Maartje Hooning</name><affiliation><nlm:aff id="aff100"><addr-line>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Martens, John W M" sort="Martens, John W M" uniqKey="Martens J" first="John W. M." last="Martens">John W. M. Martens</name><affiliation><nlm:aff id="aff101"><addr-line>Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation><nlm:aff id="aff100"><addr-line>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Collee, Margriet" sort="Collee, Margriet" uniqKey="Collee M" first="Margriet" last="Collée">Margriet Collée</name><affiliation><nlm:aff id="aff102"><addr-line>Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="aff103"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Humpreys, Keith" sort="Humpreys, Keith" uniqKey="Humpreys K" first="Keith" last="Humpreys">Keith Humpreys</name><affiliation><nlm:aff id="aff103"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="aff103"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:aff id="aff104"><addr-line>Population Genetics, Genome Institute of Singapore, Singapore, Republic of Singapore</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="aff105"><addr-line>Institute for Cancer Studies, Department of Oncology, University of Sheffield, Sheffield, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Brock, Ian W" sort="Brock, Ian W" uniqKey="Brock I" first="Ian W." last="Brock">Ian W. Brock</name><affiliation><nlm:aff id="aff105"><addr-line>Institute for Cancer Studies, Department of Oncology, University of Sheffield, Sheffield, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="aff106"><addr-line>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name><affiliation><nlm:aff id="aff107"><addr-line>Academic Unit of Surgical Oncology, Department of Oncology, University of Sheffield, Sheffield, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ahmed, Shahana" sort="Ahmed, Shahana" uniqKey="Ahmed S" first="Shahana" last="Ahmed">Shahana Ahmed</name><affiliation><nlm:aff id="aff3"><addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name><affiliation><nlm:aff id="aff3"><addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul Dp" sort="Pharoah, Paul Dp" uniqKey="Pharoah P" first="Paul Dp." last="Pharoah">Paul Dp. Pharoah</name><affiliation><nlm:aff id="aff3"><addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff108"><addr-line>Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation><nlm:aff id="aff109"><addr-line>Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</addr-line></nlm:aff></affiliation></author><author><name sortKey="Yoo, Keun Young" sort="Yoo, Keun Young" uniqKey="Yoo K" first="Keun-Young" last="Yoo">Keun-Young Yoo</name><affiliation><nlm:aff id="aff109"><addr-line>Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</addr-line></nlm:aff></affiliation></author><author><name sortKey="Noh, Dong Young" sort="Noh, Dong Young" uniqKey="Noh D" first="Dong-Young" last="Noh">Dong-Young Noh</name><affiliation><nlm:aff id="aff110"><addr-line>Department of Surgery, Seoul National University College of Medicine, Seoul, Korea</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="aff111"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jaworska, Katarzyna" sort="Jaworska, Katarzyna" uniqKey="Jaworska K" first="Katarzyna" last="Jaworska">Katarzyna Jaworska</name><affiliation><nlm:aff id="aff111"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff112"><addr-line>Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="aff111"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zlowocka, El Bieta" sort="Zlowocka, El Bieta" uniqKey="Zlowocka E" first="El Bieta" last="Złowocka">El Bieta Złowocka</name><affiliation><nlm:aff id="aff111"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name><affiliation><nlm:aff id="aff113"><addr-line>Molecular Epidemiology Unit, National Cancer Institute, Bangkok, Thailand</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gaborieau, Valerie" sort="Gaborieau, Valerie" uniqKey="Gaborieau V" first="Valerie" last="Gaborieau">Valerie Gaborieau</name><affiliation><nlm:aff id="aff114"><addr-line>Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:aff id="aff114"><addr-line>Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name><affiliation><nlm:aff id="aff114"><addr-line>Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name><affiliation><nlm:aff id="aff115"><addr-line>Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff116"><addr-line>Taiwan Biobank, Taipei, Taiwan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Yu, Jyh Cherng" sort="Yu, Jyh Cherng" uniqKey="Yu J" first="Jyh-Cherng" last="Yu">Jyh-Cherng Yu</name><affiliation><nlm:aff id="aff117"><addr-line>Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hsu, Huan Ming" sort="Hsu, Huan Ming" uniqKey="Hsu H" first="Huan-Ming" last="Hsu">Huan-Ming Hsu</name><affiliation><nlm:aff id="aff117"><addr-line>Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hou, Ming Feng" sort="Hou, Ming Feng" uniqKey="Hou M" first="Ming-Feng" last="Hou">Ming-Feng Hou</name><affiliation><nlm:aff id="aff118"><addr-line>Cancer Center and Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation><nlm:aff id="aff119"><addr-line>The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Schoemaker, Minouk" sort="Schoemaker, Minouk" uniqKey="Schoemaker M" first="Minouk" last="Schoemaker">Minouk Schoemaker</name><affiliation><nlm:aff id="aff120"><addr-line>Section of Epidemiology, Institute of Cancer Research, Sutton, Surrey, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation><nlm:aff id="aff119"><addr-line>The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="aff120"><addr-line>Section of Epidemiology, Institute of Cancer Research, Sutton, Surrey, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Trentham Dietz, Amy" sort="Trentham Dietz, Amy" uniqKey="Trentham Dietz A" first="Amy" last="Trentham-Dietz">Amy Trentham-Dietz</name><affiliation><nlm:aff id="aff121"><addr-line>University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A." last="Newcomb">Polly A. Newcomb</name><affiliation><nlm:aff id="aff121"><addr-line>University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, United States of America</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff122"><addr-line>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Titus, Linda" sort="Titus, Linda" uniqKey="Titus L" first="Linda" last="Titus">Linda Titus</name><affiliation><nlm:aff id="aff123"><addr-line>Department of Community & Family Medicine, Department of Pediatrics, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, New Hampshire, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Egan, Kathleen M" sort="Egan, Kathleen M" uniqKey="Egan K" first="Kathleen M." last="Egan">Kathleen M. Egan</name><affiliation><nlm:aff id="aff124"><addr-line>Division of Population Sciences, Moffitt Cancer Center & Research Institute, Tampa, Florida, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="aff64"><addr-line>Cancer Division, Queensland Institute of Medical Research, Brisbane, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name><affiliation><nlm:aff id="aff108"><addr-line>Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Humphreys, Manjeet K" sort="Humphreys, Manjeet K" uniqKey="Humphreys M" first="Manjeet K." last="Humphreys">Manjeet K. Humphreys</name><affiliation><nlm:aff id="aff108"><addr-line>Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Morrison, Jonathan" sort="Morrison, Jonathan" uniqKey="Morrison J" first="Jonathan" last="Morrison">Jonathan Morrison</name><affiliation><nlm:aff id="aff108"><addr-line>Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="aff1"><addr-line>Unit of Genetic Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="aff108"><addr-line>Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="aff3"><addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The 6q25.1 locus was first identified via a genome-wide association study (GWAS) in Chinese women and marked by single nucleotide polymorphism (SNP) rs2046210, approximately 180 Kb upstream of <italic>ESR1</italic>. There have been conflicting reports about the association of this locus with breast cancer in Europeans, and a GWAS in Europeans identified a different SNP, tagged here by rs12662670. We examined the associations of both SNPs in up to 61,689 cases and 58,822 controls from forty-four studies collaborating in the Breast Cancer Association Consortium, of which four studies were of Asian and 39 of European descent. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). Case-only analyses were used to compare SNP effects in Estrogen Receptor positive (ER+) versus negative (ER<bold>−</bold>) tumours. Models including both SNPs were fitted to investigate whether the SNP effects were independent. Both SNPs are significantly associated with breast cancer risk in both ethnic groups. Per-allele ORs are higher in Asian than in European studies [rs2046210: OR (A/G) = 1.36 (95% CI 1.26–1.48), p = 7.6×10<sup>−14</sup> in Asians and 1.09 (95% CI 1.07–1.11), p = 6.8×10<sup>−18</sup> in Europeans. rs12662670: OR (G/T) = 1.29 (95% CI 1.19–1.41), p = 1.2×10<sup>−9</sup> in Asians and 1.12 (95% CI 1.08–1.17), p = 3.8×10<sup>−9</sup> in Europeans]. SNP rs2046210 is associated with a significantly greater risk of ER− than ER+ tumours in Europeans [OR (ER−) = 1.20 (95% CI 1.15–1.25), p = 1.8×10<sup>−17</sup> versus OR (ER+) = 1.07 (95% CI 1.04–1.1), p = 1.3×10<sup>−7</sup>, p<sub>heterogeneity</sub> = 5.1×10<sup>−6</sup>]. In these Asian studies, by contrast, there is no clear evidence of a differential association by tumour receptor status. Each SNP is associated with risk after adjustment for the other SNP. These results suggest the presence of two variants at 6q25.1 each independently associated with breast cancer risk in Asians and in Europeans. Of these two, the one tagged by rs2046210 is associated with a greater risk of ER− tumours.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zheng, W" uniqKey="Zheng W">W Zheng</name></author><author><name sortKey="Long, J" uniqKey="Long J">J Long</name></author><author><name sortKey="Gao, Yt" uniqKey="Gao Y">YT Gao</name></author><author><name sortKey="Li, C" uniqKey="Li C">C Li</name></author><author><name sortKey="Zheng, Y" uniqKey="Zheng Y">Y Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stacey, Sn" uniqKey="Stacey S">SN Stacey</name></author><author><name sortKey="Sulem, P" uniqKey="Sulem P">P Sulem</name></author><author><name sortKey="Zanon, C" uniqKey="Zanon C">C Zanon</name></author><author><name sortKey="Gudjonsson, Sa" uniqKey="Gudjonsson S">SA Gudjonsson</name></author><author><name sortKey="Thorleifsson, G" uniqKey="Thorleifsson G">G Thorleifsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turnbull, C" uniqKey="Turnbull C">C Turnbull</name></author><author><name sortKey="Ahmed, S" uniqKey="Ahmed S">S Ahmed</name></author><author><name sortKey="Morrison, J" uniqKey="Morrison J">J Morrison</name></author><author><name sortKey="Pernet, D" uniqKey="Pernet D">D Pernet</name></author><author><name sortKey="Renwick, A" uniqKey="Renwick A">A Renwick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laird, Nm" uniqKey="Laird N">NM Laird</name></author><author><name sortKey="Mosteller, F" uniqKey="Mosteller F">F Mosteller</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Long, J" uniqKey="Long J">J Long</name></author><author><name sortKey="Shu, Xo" uniqKey="Shu X">XO Shu</name></author><author><name sortKey="Cai, Q" uniqKey="Cai Q">Q Cai</name></author><author><name sortKey="Gao, Yt" uniqKey="Gao Y">YT Gao</name></author><author><name sortKey="Zheng, Y" uniqKey="Zheng Y">Y Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Antoniou, Ac" uniqKey="Antoniou A">AC Antoniou</name></author><author><name sortKey="Kartsonaki, C" uniqKey="Kartsonaki C">C Kartsonaki</name></author><author><name sortKey="Sinilnikova, Om" uniqKey="Sinilnikova O">OM Sinilnikova</name></author><author><name sortKey="Soucy, P" uniqKey="Soucy P">P Soucy</name></author><author><name sortKey="Mcguffog, L" uniqKey="Mcguffog L">L McGuffog</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cai, Q" uniqKey="Cai Q">Q Cai</name></author><author><name sortKey="Wen, W" uniqKey="Wen W">W Wen</name></author><author><name sortKey="Qu, S" uniqKey="Qu S">S Qu</name></author><author><name sortKey="Li, G" uniqKey="Li G">G Li</name></author><author><name sortKey="Egan, Km" uniqKey="Egan K">KM Egan</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ioannidis, Jpa" uniqKey="Ioannidis J">JPA Ioannidis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kraft, P" uniqKey="Kraft P">P Kraft</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Wf" uniqKey="Li W">WF Li</name></author><author><name sortKey="Hou, Sx" uniqKey="Hou S">SX Hou</name></author><author><name sortKey="Yu, B" uniqKey="Yu B">B Yu</name></author><author><name sortKey="Li, Mm" uniqKey="Li M">MM Li</name></author><author><name sortKey="Ferec, C" uniqKey="Ferec C">C Ferec</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xie, H" uniqKey="Xie H">H Xie</name></author><author><name sortKey="Sun, M" uniqKey="Sun M">M Sun</name></author><author><name sortKey="Liao, Xb" uniqKey="Liao X">XB Liao</name></author><author><name sortKey="Yuan, Lq" uniqKey="Yuan L">LQ Yuan</name></author><author><name sortKey="Sheng, Zf" uniqKey="Sheng Z">ZF Sheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dunbier, Ak" uniqKey="Dunbier A">AK Dunbier</name></author><author><name sortKey="Anderson, H" uniqKey="Anderson H">H Anderson</name></author><author><name sortKey="Ghazoui, Z" uniqKey="Ghazoui Z">Z Ghazoui</name></author><author><name sortKey="Lopez Knowles, E" uniqKey="Lopez Knowles E">E Lopez-Knowles</name></author><author><name sortKey="Pancholi, S" uniqKey="Pancholi S">S Pancholi</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22879957</article-id><article-id pub-id-type="pmc">3413660</article-id><article-id pub-id-type="publisher-id">PONE-D-12-09200</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0042380</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Biology</subject><subj-group><subject>Computational Biology</subject><subj-group><subject>Genomics</subject><subj-group><subject>Genome Analysis Tools</subject><subj-group><subject>Genome-Wide Association Studies</subject></subj-group></subj-group></subj-group></subj-group><subj-group><subject>Genetics</subject><subj-group><subject>Human Genetics</subject><subj-group><subject>Genetic Association Studies</subject></subj-group></subj-group><subj-group><subject>Cancer Genetics</subject><subject>Genetics of Disease</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Mathematics</subject><subj-group><subject>Statistics</subject><subj-group><subject>Biostatistics</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine</subject><subj-group><subject>Epidemiology</subject><subj-group><subject>Cancer Epidemiology</subject><subject>Genetic Epidemiology</subject></subj-group></subj-group><subj-group><subject>Obstetrics and Gynecology</subject><subj-group><subject>Breast Cancer</subject></subj-group></subj-group><subj-group><subject>Oncology</subject><subj-group><subject>Cancer Risk Factors</subject><subj-group><subject>Genetic Causes of Cancer</subject></subj-group></subj-group></subj-group></subj-group></article-categories><title-group><article-title>Comparison of 6q25 Breast Cancer Hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC)</article-title><alt-title alt-title-type="running-head">6q25 Breast Cancer GWAS Hits</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Hein</surname><given-names>Rebecca</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Maranian</surname><given-names>Melanie</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hopper</surname><given-names>John L.</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kapuscinski</surname><given-names>Miroslaw K.</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Southey</surname><given-names>Melissa C.</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Park</surname><given-names>Daniel J.</given-names></name><xref ref-type="aff" rid="aff6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>Marjanka K.</given-names></name><xref ref-type="aff" rid="aff7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Broeks</surname><given-names>Annegien</given-names></name><xref ref-type="aff" rid="aff7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hogervorst</surname><given-names>Frans B. L.</given-names></name><xref ref-type="aff" rid="aff8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bueno-de-Mesquit</surname><given-names>H. Bas</given-names></name><xref ref-type="aff" rid="aff9"><sup>9</sup></xref></contrib><contrib contrib-type="author"><name><surname>Muir</surname><given-names>Kenneth R.</given-names></name><xref ref-type="aff" rid="aff10"><sup>10</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lophatananon</surname><given-names>Artitaya</given-names></name><xref ref-type="aff" rid="aff10"><sup>10</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rattanamongkongul</surname><given-names>Suthee</given-names></name><xref ref-type="aff" rid="aff11"><sup>11</sup></xref></contrib><contrib contrib-type="author"><name><surname>Puttawibul</surname><given-names>Puttisak</given-names></name><xref ref-type="aff" rid="aff12"><sup>12</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fasching</surname><given-names>Peter A.</given-names></name><xref ref-type="aff" rid="aff13"><sup>13</sup></xref><xref ref-type="aff" rid="aff14"><sup>14</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hein</surname><given-names>Alexander</given-names></name><xref ref-type="aff" rid="aff13"><sup>13</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ekici</surname><given-names>Arif B.</given-names></name><xref ref-type="aff" rid="aff15"><sup>15</sup></xref></contrib><contrib contrib-type="author"><name><surname>Beckmann</surname><given-names>Matthias W.</given-names></name><xref ref-type="aff" rid="aff13"><sup>13</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fletcher</surname><given-names>Olivia</given-names></name><xref ref-type="aff" rid="aff16"><sup>16</sup></xref></contrib><contrib contrib-type="author"><name><surname>Johnson</surname><given-names>Nichola</given-names></name><xref ref-type="aff" rid="aff16"><sup>16</sup></xref></contrib><contrib contrib-type="author"><name><surname>dos Santos Silva</surname><given-names>Isabel</given-names></name><xref ref-type="aff" rid="aff17"><sup>17</sup></xref></contrib><contrib contrib-type="author"><name><surname>Peto</surname><given-names>Julian</given-names></name><xref ref-type="aff" rid="aff17"><sup>17</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sawyer</surname><given-names>Elinor</given-names></name><xref ref-type="aff" rid="aff18"><sup>18</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tomlinson</surname><given-names>Ian</given-names></name><xref ref-type="aff" rid="aff19"><sup>19</sup></xref><xref ref-type="aff" rid="aff20"><sup>20</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kerin</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="aff21"><sup>21</sup></xref></contrib><contrib contrib-type="author"><name><surname>Miller</surname><given-names>Nicola</given-names></name><xref ref-type="aff" rid="aff22"><sup>22</sup></xref></contrib><contrib contrib-type="author"><name><surname>Marmee</surname><given-names>Frederick</given-names></name><xref ref-type="aff" rid="aff22"><sup>22</sup></xref><xref ref-type="aff" rid="aff23"><sup>23</sup></xref></contrib><contrib contrib-type="author"><name><surname>Schneeweiss</surname><given-names>Andreas</given-names></name><xref ref-type="aff" rid="aff22"><sup>22</sup></xref><xref ref-type="aff" rid="aff23"><sup>23</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sohn</surname><given-names>Christof</given-names></name><xref ref-type="aff" rid="aff22"><sup>22</sup></xref></contrib><contrib contrib-type="author"><name><surname>Burwinkel</surname><given-names>Barbara</given-names></name><xref ref-type="aff" rid="aff22"><sup>22</sup></xref><xref ref-type="aff" rid="aff24"><sup>24</sup></xref></contrib><contrib contrib-type="author"><name><surname>Guénel</surname><given-names>Pascal</given-names></name><xref ref-type="aff" rid="aff25"><sup>25</sup></xref><xref ref-type="aff" rid="aff26"><sup>26</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cordina-Duverger</surname><given-names>Emilie</given-names></name><xref ref-type="aff" rid="aff25"><sup>25</sup></xref><xref ref-type="aff" rid="aff26"><sup>26</sup></xref></contrib><contrib contrib-type="author"><name><surname>Menegaux</surname><given-names>Florence</given-names></name><xref ref-type="aff" rid="aff25"><sup>25</sup></xref><xref ref-type="aff" rid="aff26"><sup>26</sup></xref></contrib><contrib contrib-type="author"><name><surname>Truong</surname><given-names>Thérèse</given-names></name><xref ref-type="aff" rid="aff25"><sup>25</sup></xref><xref ref-type="aff" rid="aff26"><sup>26</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bojesen</surname><given-names>Stig E.</given-names></name><xref ref-type="aff" rid="aff27"><sup>27</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nordestgaard</surname><given-names>Børge G.</given-names></name><xref ref-type="aff" rid="aff27"><sup>27</sup></xref></contrib><contrib contrib-type="author"><name><surname>Flyger</surname><given-names>Henrik</given-names></name><xref ref-type="aff" rid="aff28"><sup>28</sup></xref></contrib><contrib contrib-type="author"><name><surname>Milne</surname><given-names>Roger L.</given-names></name><xref ref-type="aff" rid="aff29"><sup>29</sup></xref></contrib><contrib contrib-type="author"><name><surname>Perez</surname><given-names>Jose Ignacio Arias</given-names></name><xref ref-type="aff" rid="aff30"><sup>30</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zamora</surname><given-names>M. Pilar</given-names></name><xref ref-type="aff" rid="aff31"><sup>31</sup></xref></contrib><contrib contrib-type="author"><name><surname>Benítez</surname><given-names>Javier</given-names></name><xref ref-type="aff" rid="aff32"><sup>32</sup></xref></contrib><contrib contrib-type="author"><name><surname>Anton-Culver</surname><given-names>Hoda</given-names></name><xref ref-type="aff" rid="aff33"><sup>33</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ziogas</surname><given-names>Argyrios</given-names></name><xref ref-type="aff" rid="aff33"><sup>33</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bernstein</surname><given-names>Leslie</given-names></name><xref ref-type="aff" rid="aff34"><sup>34</sup></xref></contrib><contrib contrib-type="author"><name><surname>Clarke</surname><given-names>Christina A.</given-names></name><xref ref-type="aff" rid="aff35"><sup>35</sup></xref></contrib><contrib contrib-type="author"><name><surname>Brenner</surname><given-names>Hermann</given-names></name><xref ref-type="aff" rid="aff36"><sup>36</sup></xref></contrib><contrib contrib-type="author"><name><surname>Müller</surname><given-names>Heiko</given-names></name><xref ref-type="aff" rid="aff36"><sup>36</sup></xref></contrib><contrib contrib-type="author"><name><surname>Arndt</surname><given-names>Volker</given-names></name><xref ref-type="aff" rid="aff36"><sup>36</sup></xref></contrib><contrib contrib-type="author"><name><surname>Stegmaier</surname><given-names>Christa</given-names></name><xref ref-type="aff" rid="aff37"><sup>37</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rahman</surname><given-names>Nazneen</given-names></name><xref ref-type="aff" rid="aff38"><sup>38</sup></xref></contrib><contrib contrib-type="author"><name><surname>Seal</surname><given-names>Sheila</given-names></name><xref ref-type="aff" rid="aff38"><sup>38</sup></xref></contrib><contrib contrib-type="author"><name><surname>Turnbull</surname><given-names>Clare</given-names></name><xref ref-type="aff" rid="aff38"><sup>38</sup></xref></contrib><contrib contrib-type="author"><name><surname>Renwick</surname><given-names>Anthony</given-names></name><xref ref-type="aff" rid="aff38"><sup>38</sup></xref></contrib><contrib contrib-type="author"><name><surname>Meindl</surname><given-names>Alfons</given-names></name><xref ref-type="aff" rid="aff39"><sup>39</sup></xref></contrib><contrib contrib-type="author"><name><surname>Schott</surname><given-names>Sarah</given-names></name><xref ref-type="aff" rid="aff40"><sup>40</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bartram</surname><given-names>Claus R.</given-names></name><xref ref-type="aff" rid="aff41"><sup>41</sup></xref></contrib><contrib contrib-type="author"><name><surname>Schmutzler</surname><given-names>Rita K.</given-names></name><xref ref-type="aff" rid="aff42"><sup>42</sup></xref></contrib><contrib contrib-type="author"><name><surname>Brauch</surname><given-names>Hiltrud</given-names></name><xref ref-type="aff" rid="aff43"><sup>43</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hamann</surname><given-names>Ute</given-names></name><xref ref-type="aff" rid="aff44"><sup>44</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ko</surname><given-names>Yon-Dschun</given-names></name><xref ref-type="aff" rid="aff45"><sup>45</sup></xref></contrib><contrib contrib-type="author"><collab>The GENICA Network</collab><xref ref-type="aff" rid="aff43"><sup>43</sup></xref><xref ref-type="aff" rid="aff44"><sup>44</sup></xref><xref ref-type="aff" rid="aff45"><sup>45</sup></xref><xref ref-type="aff" rid="aff46"><sup>46</sup></xref><xref ref-type="aff" rid="aff47"><sup>47</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wang-Gohrke</surname><given-names>Shan</given-names></name><xref ref-type="aff" rid="aff48"><sup>48</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dörk</surname><given-names>Thilo</given-names></name><xref ref-type="aff" rid="aff49"><sup>49</sup></xref></contrib><contrib contrib-type="author"><name><surname>Schürmann</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="aff49"><sup>49</sup></xref></contrib><contrib contrib-type="author"><name><surname>Karstens</surname><given-names>Johann H.</given-names></name><xref ref-type="aff" rid="aff50"><sup>50</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hillemanns</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="aff49"><sup>49</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nevanlinna</surname><given-names>Heli</given-names></name><xref ref-type="aff" rid="aff51"><sup>51</sup></xref></contrib><contrib contrib-type="author"><name><surname>Heikkinen</surname><given-names>Tuomas</given-names></name><xref ref-type="aff" rid="aff51"><sup>51</sup></xref></contrib><contrib contrib-type="author"><name><surname>Aittomäki</surname><given-names>Kristiina</given-names></name><xref ref-type="aff" rid="aff52"><sup>52</sup></xref></contrib><contrib contrib-type="author"><name><surname>Blomqvist</surname><given-names>Carl</given-names></name><xref ref-type="aff" rid="aff53"><sup>53</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bogdanova</surname><given-names>Natalia V.</given-names></name><xref ref-type="aff" rid="aff54"><sup>54</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zalutsky</surname><given-names>Iosif V.</given-names></name><xref ref-type="aff" rid="aff55"><sup>55</sup></xref></contrib><contrib contrib-type="author"><name><surname>Antonenkova</surname><given-names>Natalia N.</given-names></name><xref ref-type="aff" rid="aff55"><sup>55</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bermisheva</surname><given-names>Marina</given-names></name><xref ref-type="aff" rid="aff56"><sup>56</sup></xref></contrib><contrib contrib-type="author"><name><surname>Prokovieva</surname><given-names>Darya</given-names></name><xref ref-type="aff" rid="aff56"><sup>56</sup></xref></contrib><contrib contrib-type="author"><name><surname>Farahtdinova</surname><given-names>Albina</given-names></name><xref ref-type="aff" rid="aff56"><sup>56</sup></xref></contrib><contrib contrib-type="author"><name><surname>Khusnutdinova</surname><given-names>Elza</given-names></name><xref ref-type="aff" rid="aff56"><sup>56</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lindblom</surname><given-names>Annika</given-names></name><xref ref-type="aff" rid="aff57"><sup>57</sup></xref></contrib><contrib contrib-type="author"><name><surname>Margolin</surname><given-names>Sara</given-names></name><xref ref-type="aff" rid="aff58"><sup>58</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mannermaa</surname><given-names>Arto</given-names></name><xref ref-type="aff" rid="aff58"><sup>58</sup></xref><xref ref-type="aff" rid="aff50"><sup>50</sup></xref><xref ref-type="aff" rid="aff60"><sup>60</sup></xref><xref ref-type="aff" rid="aff61"><sup>61</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kataja</surname><given-names>Vesa</given-names></name><xref ref-type="aff" rid="aff60"><sup>60</sup></xref><xref ref-type="aff" rid="aff62"><sup>62</sup></xref><xref ref-type="aff" rid="aff63"><sup>63</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kosma</surname><given-names>Veli-Matti</given-names></name><xref ref-type="aff" rid="aff59"><sup>59</sup></xref><xref ref-type="aff" rid="aff60"><sup>60</sup></xref><xref ref-type="aff" rid="aff61"><sup>61</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hartikainen</surname><given-names>Jaana</given-names></name><xref ref-type="aff" rid="aff59"><sup>59</sup></xref><xref ref-type="aff" rid="aff60"><sup>60</sup></xref><xref ref-type="aff" rid="aff61"><sup>61</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Xiaoqing</given-names></name><xref ref-type="aff" rid="aff64"><sup>64</sup></xref></contrib><contrib contrib-type="author"><name><surname>Beesley</surname><given-names>Jonathan</given-names></name><xref ref-type="aff" rid="aff64"><sup>64</sup></xref></contrib><contrib contrib-type="author"><name><surname>Investigators</surname><given-names>kConFab</given-names></name><xref ref-type="aff" rid="aff65"><sup>65</sup></xref></contrib><contrib contrib-type="author"><collab>AOCS Group</collab><xref ref-type="aff" rid="aff66"><sup>66</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lambrechts</surname><given-names>Diether</given-names></name><xref ref-type="aff" rid="aff67"><sup>67</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Hui</given-names></name><xref ref-type="aff" rid="aff67"><sup>67</sup></xref></contrib><contrib contrib-type="author"><name><surname>Neven</surname><given-names>Patrick</given-names></name><xref ref-type="aff" rid="aff68"><sup>68</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wildiers</surname><given-names>Hans</given-names></name><xref ref-type="aff" rid="aff68"><sup>68</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nickels</surname><given-names>Stefan</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Flesch-Janys</surname><given-names>Dieter</given-names></name><xref ref-type="aff" rid="aff69"><sup>69</sup></xref></contrib><contrib contrib-type="author"><name><surname>Radice</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="aff70"><sup>70</sup></xref><xref ref-type="aff" rid="aff71"><sup>71</sup></xref></contrib><contrib contrib-type="author"><name><surname>Peterlongo</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="aff70"><sup>70</sup></xref><xref ref-type="aff" rid="aff71"><sup>71</sup></xref></contrib><contrib contrib-type="author"><name><surname>Manoukian</surname><given-names>Siranoush</given-names></name><xref ref-type="aff" rid="aff72"><sup>72</sup></xref></contrib><contrib contrib-type="author"><name><surname>Barile</surname><given-names>Monica</given-names></name><xref ref-type="aff" rid="aff73"><sup>73</sup></xref></contrib><contrib contrib-type="author"><name><surname>Couch</surname><given-names>Fergus J.</given-names></name><xref ref-type="aff" rid="aff74"><sup>74</sup></xref></contrib><contrib contrib-type="author"><name><surname>Olson</surname><given-names>Janet E.</given-names></name><xref ref-type="aff" rid="aff74"><sup>74</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Xianshu</given-names></name><xref ref-type="aff" rid="aff75"><sup>75</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fredericksen</surname><given-names>Zachary</given-names></name><xref ref-type="aff" rid="aff74"><sup>74</sup></xref></contrib><contrib contrib-type="author"><name><surname>Giles</surname><given-names>Graham G.</given-names></name><xref ref-type="aff" rid="aff76"><sup>76</sup></xref><xref ref-type="aff" rid="aff77"><sup>77</sup></xref></contrib><contrib contrib-type="author"><name><surname>Baglietto</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="aff76"><sup>76</sup></xref><xref ref-type="aff" rid="aff77"><sup>77</sup></xref></contrib><contrib contrib-type="author"><name><surname>McLean</surname><given-names>Catriona A.</given-names></name><xref ref-type="aff" rid="aff78"><sup>78</sup></xref></contrib><contrib contrib-type="author"><name><surname>Severi</surname><given-names>Gianluca</given-names></name><xref ref-type="aff" rid="aff76"><sup>76</sup></xref><xref ref-type="aff" rid="aff77"><sup>77</sup></xref></contrib><contrib contrib-type="author"><name><surname>Offit</surname><given-names>Kenneth</given-names></name><xref ref-type="aff" rid="aff79"><sup>79</sup></xref></contrib><contrib contrib-type="author"><name><surname>Robson</surname><given-names>Mark</given-names></name><xref ref-type="aff" rid="aff80"><sup>80</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gaudet</surname><given-names>Mia M.</given-names></name><xref ref-type="aff" rid="aff81"><sup>81</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vijai</surname><given-names>Joseph</given-names></name><xref ref-type="aff" rid="aff79"><sup>79</sup></xref></contrib><contrib contrib-type="author"><name><surname>Alnæs</surname><given-names>Grethe Grenaker</given-names></name><xref ref-type="aff" rid="aff82"><sup>82</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kristensen</surname><given-names>Vessela</given-names></name><xref ref-type="aff" rid="aff82"><sup>82</sup></xref><xref ref-type="aff" rid="aff83"><sup>83</sup></xref></contrib><contrib contrib-type="author"><name><surname>Børresen-Dale</surname><given-names>Anne-Lise</given-names></name><xref ref-type="aff" rid="aff82"><sup>82</sup></xref><xref ref-type="aff" rid="aff83"><sup>83</sup></xref></contrib><contrib contrib-type="author"><name><surname>John</surname><given-names>Esther M.</given-names></name><xref ref-type="aff" rid="aff84"><sup>84</sup></xref><xref ref-type="aff" rid="aff85"><sup>85</sup></xref></contrib><contrib contrib-type="author"><name><surname>Miron</surname><given-names>Alexander</given-names></name><xref ref-type="aff" rid="aff86"><sup>86</sup></xref></contrib><contrib contrib-type="author"><name><surname>Winqvist</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="aff87"><sup>87</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pylkäs</surname><given-names>Katri</given-names></name><xref ref-type="aff" rid="aff87"><sup>87</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jukkola-Vuorinen</surname><given-names>Arja</given-names></name><xref ref-type="aff" rid="aff88"><sup>88</sup></xref></contrib><contrib contrib-type="author"><name><surname>Grip</surname><given-names>Mervi</given-names></name><xref ref-type="aff" rid="aff89"><sup>89</sup></xref></contrib><contrib contrib-type="author"><name><surname>Andrulis</surname><given-names>Irene L.</given-names></name><xref ref-type="aff" rid="aff90"><sup>90</sup></xref><xref ref-type="aff" rid="aff91"><sup>91</sup></xref><xref ref-type="aff" rid="aff92"><sup>92</sup></xref></contrib><contrib contrib-type="author"><name><surname>Knight</surname><given-names>Julia A.</given-names></name><xref ref-type="aff" rid="aff93"><sup>93</sup></xref><xref ref-type="aff" rid="aff94"><sup>94</sup></xref></contrib><contrib contrib-type="author"><name><surname>Glendon</surname><given-names>Gord</given-names></name><xref ref-type="aff" rid="aff90"><sup>90</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mulligan</surname><given-names>Anna Marie</given-names></name><xref ref-type="aff" rid="aff95"><sup>95</sup></xref><xref ref-type="aff" rid="aff96"><sup>96</sup></xref></contrib><contrib contrib-type="author"><name><surname>Figueroa</surname><given-names>Jonine D.</given-names></name><xref ref-type="aff" rid="aff97"><sup>97</sup></xref></contrib><contrib contrib-type="author"><name><surname>García-Closas</surname><given-names>Montserrat</given-names></name><xref ref-type="aff" rid="aff97"><sup>97</sup></xref><xref ref-type="aff" rid="aff98"><sup>98</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lissowska</surname><given-names>Jolanta</given-names></name><xref ref-type="aff" rid="aff99"><sup>99</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sherman</surname><given-names>Mark E.</given-names></name><xref ref-type="aff" rid="aff97"><sup>97</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hooning</surname><given-names>Maartje</given-names></name><xref ref-type="aff" rid="aff100"><sup>100</sup></xref></contrib><contrib contrib-type="author"><name><surname>Martens</surname><given-names>John W. M.</given-names></name><xref ref-type="aff" rid="aff101"><sup>101</sup></xref></contrib><contrib contrib-type="author"><name><surname>Seynaeve</surname><given-names>Caroline</given-names></name><xref ref-type="aff" rid="aff100"><sup>100</sup></xref></contrib><contrib contrib-type="author"><name><surname>Collée</surname><given-names>Margriet</given-names></name><xref ref-type="aff" rid="aff102"><sup>102</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>Per</given-names></name><xref ref-type="aff" rid="aff103"><sup>103</sup></xref></contrib><contrib contrib-type="author"><name><surname>Humpreys</surname><given-names>Keith</given-names></name><xref ref-type="aff" rid="aff103"><sup>103</sup></xref></contrib><contrib contrib-type="author"><name><surname>Czene</surname><given-names>Kamila</given-names></name><xref ref-type="aff" rid="aff103"><sup>103</sup></xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Jianjun</given-names></name><xref ref-type="aff" rid="aff104"><sup>104</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cox</surname><given-names>Angela</given-names></name><xref ref-type="aff" rid="aff105"><sup>105</sup></xref></contrib><contrib contrib-type="author"><name><surname>Brock</surname><given-names>Ian W.</given-names></name><xref ref-type="aff" rid="aff105"><sup>105</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cross</surname><given-names>Simon S.</given-names></name><xref ref-type="aff" rid="aff106"><sup>106</sup></xref></contrib><contrib contrib-type="author"><name><surname>Reed</surname><given-names>Malcolm W. R.</given-names></name><xref ref-type="aff" rid="aff107"><sup>107</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ahmed</surname><given-names>Shahana</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ghoussaini</surname><given-names>Maya</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pharoah</surname><given-names>Paul DP.</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="aff" rid="aff108"><sup>108</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kang</surname><given-names>Daehee</given-names></name><xref ref-type="aff" rid="aff109"><sup>109</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yoo</surname><given-names>Keun-Young</given-names></name><xref ref-type="aff" rid="aff109"><sup>109</sup></xref></contrib><contrib contrib-type="author"><name><surname>Noh</surname><given-names>Dong-Young</given-names></name><xref ref-type="aff" rid="aff110"><sup>110</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jakubowska</surname><given-names>Anna</given-names></name><xref ref-type="aff" rid="aff111"><sup>111</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jaworska</surname><given-names>Katarzyna</given-names></name><xref ref-type="aff" rid="aff111"><sup>111</sup></xref><xref ref-type="aff" rid="aff112"><sup>112</sup></xref></contrib><contrib contrib-type="author"><name><surname>Durda</surname><given-names>Katarzyna</given-names></name><xref ref-type="aff" rid="aff111"><sup>111</sup></xref></contrib><contrib contrib-type="author"><name><surname>Złowocka</surname><given-names>Elżbieta</given-names></name><xref ref-type="aff" rid="aff111"><sup>111</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sangrajrang</surname><given-names>Suleeporn</given-names></name><xref ref-type="aff" rid="aff113"><sup>113</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gaborieau</surname><given-names>Valerie</given-names></name><xref ref-type="aff" rid="aff114"><sup>114</sup></xref></contrib><contrib contrib-type="author"><name><surname>Brennan</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="aff114"><sup>114</sup></xref></contrib><contrib contrib-type="author"><name><surname>McKay</surname><given-names>James</given-names></name><xref ref-type="aff" rid="aff114"><sup>114</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shen</surname><given-names>Chen-Yang</given-names></name><xref ref-type="aff" rid="aff115"><sup>115</sup></xref><xref ref-type="aff" rid="aff116"><sup>116</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yu</surname><given-names>Jyh-Cherng</given-names></name><xref ref-type="aff" rid="aff117"><sup>117</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hsu</surname><given-names>Huan-Ming</given-names></name><xref ref-type="aff" rid="aff117"><sup>117</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hou</surname><given-names>Ming-Feng</given-names></name><xref ref-type="aff" rid="aff118"><sup>118</sup></xref></contrib><contrib contrib-type="author"><name><surname>Orr</surname><given-names>Nick</given-names></name><xref ref-type="aff" rid="aff119"><sup>119</sup></xref></contrib><contrib contrib-type="author"><name><surname>Schoemaker</surname><given-names>Minouk</given-names></name><xref ref-type="aff" rid="aff120"><sup>120</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ashworth</surname><given-names>Alan</given-names></name><xref ref-type="aff" rid="aff119"><sup>119</sup></xref></contrib><contrib contrib-type="author"><name><surname>Swerdlow</surname><given-names>Anthony</given-names></name><xref ref-type="aff" rid="aff120"><sup>120</sup></xref></contrib><contrib contrib-type="author"><name><surname>Trentham-Dietz</surname><given-names>Amy</given-names></name><xref ref-type="aff" rid="aff121"><sup>121</sup></xref></contrib><contrib contrib-type="author"><name><surname>Newcomb</surname><given-names>Polly A.</given-names></name><xref ref-type="aff" rid="aff121"><sup>121</sup></xref><xref ref-type="aff" rid="aff122"><sup>122</sup></xref></contrib><contrib contrib-type="author"><name><surname>Titus</surname><given-names>Linda</given-names></name><xref ref-type="aff" rid="aff123"><sup>123</sup></xref></contrib><contrib contrib-type="author"><name><surname>Egan</surname><given-names>Kathleen M.</given-names></name><xref ref-type="aff" rid="aff124"><sup>124</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><xref ref-type="aff" rid="aff64"><sup>64</sup></xref></contrib><contrib contrib-type="author"><name><surname>Antoniou</surname><given-names>Antonis C.</given-names></name><xref ref-type="aff" rid="aff108"><sup>108</sup></xref></contrib><contrib contrib-type="author"><name><surname>Humphreys</surname><given-names>Manjeet K.</given-names></name><xref ref-type="aff" rid="aff108"><sup>108</sup></xref></contrib><contrib contrib-type="author"><name><surname>Morrison</surname><given-names>Jonathan</given-names></name><xref ref-type="aff" rid="aff108"><sup>108</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chang-Claude</surname><given-names>Jenny</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F.</given-names></name><xref ref-type="aff" rid="aff108"><sup>108</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dunning</surname><given-names>Alison M.</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Unit of Genetic Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line></aff><aff id="aff2"><label>2</label><addr-line>PMV (Primärmedizinische Versorgung) Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany</addr-line></aff><aff id="aff3"><label>3</label><addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line></aff><aff id="aff4"><label>4</label><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia</addr-line></aff><aff id="aff5"><label>5</label><addr-line>Department of Pathology, The University of Melbourne, Melbourne, Australia</addr-line></aff><aff id="aff6"><label>6</label><addr-line>Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Australia</addr-line></aff><aff id="aff7"><label>7</label><addr-line>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</addr-line></aff><aff id="aff8"><label>8</label><addr-line>Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</addr-line></aff><aff id="aff9"><label>9</label><addr-line>National Institute for Public Health and the Environment, Bilthoven, The Netherlands</addr-line></aff><aff id="aff10"><label>10</label><addr-line>Health Sciences Research Institute, Warwick Medical School, Warwick University, Coventry, Warwick, United Kingdom</addr-line></aff><aff id="aff11"><label>11</label><addr-line>Department of Preventive Medicine, Srinakhrainwirot University, Ongkharak, Nakhon Nayok, Thailand</addr-line></aff><aff id="aff12"><label>12</label><addr-line>Department of Surgery, Medical School, Prince Songkla University, Songkla, Thailand</addr-line></aff><aff id="aff13"><label>13</label><addr-line>University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany</addr-line></aff><aff id="aff14"><label>14</label><addr-line>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California, United States of America</addr-line></aff><aff id="aff15"><label>15</label><addr-line>Institute of Human Genetics, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany</addr-line></aff><aff id="aff16"><label>16</label><addr-line>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</addr-line></aff><aff id="aff17"><label>17</label><addr-line>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line></aff><aff id="aff18"><label>18</label><addr-line>Division of Cancer Studies, National Institute for Health Research Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ National Health Service Foundation Trust in partnership with King’s College London, London, United Kingdom</addr-line></aff><aff id="aff19"><label>19</label><addr-line>Welcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom</addr-line></aff><aff id="aff20"><label>20</label><addr-line>Oxford National Institute for Health Research Comprehensive Biomedical Research Centre, Oxford, United Kingdom</addr-line></aff><aff id="aff21"><label>21</label><addr-line>Clinical Science Institute. University Hospital Galway, Galway, Ireland</addr-line></aff><aff id="aff22"><label>22</label><addr-line>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</addr-line></aff><aff id="aff23"><label>23</label><addr-line>National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</addr-line></aff><aff id="aff24"><label>24</label><addr-line>Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line></aff><aff id="aff25"><label>25</label><addr-line>Environmental Epidemiology of Cancer, U1018, CESP (Center for Research in Epidemiology and Population Health), Inserm (National Institute of Health and Medical Research), Villejuif, France</addr-line></aff><aff id="aff26"><label>26</label><addr-line>Unité mixte de recherche 1018, University Paris-Sud, Villejuif, France</addr-line></aff><aff id="aff27"><label>27</label><addr-line>Copenhagen General Population Study and Department of Clinical Biochemistry, Herlev University Hospital, University of Copenhagen, Copenhagen, Denmark</addr-line></aff><aff id="aff28"><label>28</label><addr-line>Department of Breast Surgery, Herlev University Hospital, University of Copenhagen, Copenhagen, Denmark</addr-line></aff><aff id="aff29"><label>29</label><addr-line>Genetic & Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</addr-line></aff><aff id="aff30"><label>30</label><addr-line>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain</addr-line></aff><aff id="aff31"><label>31</label><addr-line>Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain</addr-line></aff><aff id="aff32"><label>32</label><addr-line>Cancer Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</addr-line></aff><aff id="aff33"><label>33</label><addr-line>Department of Epidemiology, University of California Irvine, Irvine, California, United States of America</addr-line></aff><aff id="aff34"><label>34</label><addr-line>Department of Population Sciences, City of Hope, Duarte, California, United States of America</addr-line></aff><aff id="aff35"><label>35</label><addr-line>Cancer Prevention Institute of California, Fremont, California, United States of America</addr-line></aff><aff id="aff36"><label>36</label><addr-line>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</addr-line></aff><aff id="aff37"><label>37</label><addr-line>Saarland Cancer Registry, Saarbrücken, Germany</addr-line></aff><aff id="aff38"><label>38</label><addr-line>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom</addr-line></aff><aff id="aff39"><label>39</label><addr-line>Division of Gynecology and Obstetrics, Klinikum rechts der Isar at the Technical University Munich, Munich, Germany</addr-line></aff><aff id="aff40"><label>40</label><addr-line>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</addr-line></aff><aff id="aff41"><label>41</label><addr-line>Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany</addr-line></aff><aff id="aff42"><label>42</label><addr-line>Center for Familial Breast and Ovarian Cancer and Center of Integrated Oncology (CIO), University Hospital, Cologne, Germany</addr-line></aff><aff id="aff43"><label>43</label><addr-line>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, University of Tübingen, Tübingen, Germany</addr-line></aff><aff id="aff44"><label>44</label><addr-line>Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany</addr-line></aff><aff id="aff45"><label>45</label><addr-line>Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany</addr-line></aff><aff id="aff46"><label>46</label><addr-line>Institute of Pathology, University of Bonn, Bonn, Germany</addr-line></aff><aff id="aff47"><label>47</label><addr-line>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum, Germany</addr-line></aff><aff id="aff48"><label>48</label><addr-line>Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</addr-line></aff><aff id="aff49"><label>49</label><addr-line>Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</addr-line></aff><aff id="aff50"><label>50</label><addr-line>Clinics of Radiation Oncology, Hannover Medical School, Hannover, Germany</addr-line></aff><aff id="aff51"><label>51</label><addr-line>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</addr-line></aff><aff id="aff52"><label>52</label><addr-line>Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</addr-line></aff><aff id="aff53"><label>53</label><addr-line>Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland</addr-line></aff><aff id="aff54"><label>54</label><addr-line>Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany, Clinics of Radiation Oncology, Hannover Medical School, Hannover, Germany</addr-line></aff><aff id="aff55"><label>55</label><addr-line>N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus</addr-line></aff><aff id="aff56"><label>56</label><addr-line>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</addr-line></aff><aff id="aff57"><label>57</label><addr-line>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</addr-line></aff><aff id="aff58"><label>58</label><addr-line>Department of Oncology Pathology, Karolinska Institutet, Stockholm, Sweden</addr-line></aff><aff id="aff59"><label>59</label><addr-line>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</addr-line></aff><aff id="aff60"><label>60</label><addr-line>Biocenter Kuopio, Kuopio University Hospital, Kuopio, Finland</addr-line></aff><aff id="aff61"><label>61</label><addr-line>Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</addr-line></aff><aff id="aff62"><label>62</label><addr-line>School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, Kuopio, Finland</addr-line></aff><aff id="aff63"><label>63</label><addr-line>Department of Oncology, Kuopio University Hospital, Kuopio, Finland</addr-line></aff><aff id="aff64"><label>64</label><addr-line>Cancer Division, Queensland Institute of Medical Research, Brisbane, Australia</addr-line></aff><aff id="aff65"><label>65</label><addr-line>Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer [kConFab], Peter MacCallum Cancer Center, Melbourne, Australia</addr-line></aff><aff id="aff66"><label>66</label><addr-line>Australian Ovarian Cancer Study [AOCS], Peter MacCallum Cancer Center, Melbourne, Australia</addr-line></aff><aff id="aff67"><label>67</label><addr-line>Vesalius Research Center (VRC), Vesalius Research Center, Leuven, Belgium; Vesalius Research Center (VRC), Katholieke Universiteit (KU) Leuven, Leuven, Belgium</addr-line></aff><aff id="aff68"><label>68</label><addr-line>Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium</addr-line></aff><aff id="aff69"><label>69</label><addr-line>Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</addr-line></aff><aff id="aff70"><label>70</label><addr-line>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</addr-line></aff><aff id="aff71"><label>71</label><addr-line>Fondazione Istituto FIRC (Fondazione Italiana per la Ricerca sul Cancro) Di Oncologia Molecolare (IFOM), Milan, Italy</addr-line></aff><aff id="aff72"><label>72</label><addr-line>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione Instituto di Recuvero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale Tumori (INT), Milan, Italy</addr-line></aff><aff id="aff73"><label>73</label><addr-line>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy</addr-line></aff><aff id="aff74"><label>74</label><addr-line>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></aff><aff id="aff75"><label>75</label><addr-line>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></aff><aff id="aff76"><label>76</label><addr-line>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</addr-line></aff><aff id="aff77"><label>77</label><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia</addr-line></aff><aff id="aff78"><label>78</label><addr-line>Department of Anatomical Pathology, The Alfred Hospital, Melbourne, Australia</addr-line></aff><aff id="aff79"><label>79</label><addr-line>Clinical Genetics Service, Dept. of Medicine and Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America</addr-line></aff><aff id="aff80"><label>80</label><addr-line>Clinical Genetics Service, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America</addr-line></aff><aff id="aff81"><label>81</label><addr-line>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, United States of America</addr-line></aff><aff id="aff82"><label>82</label><addr-line>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</addr-line></aff><aff id="aff83"><label>83</label><addr-line>Faculty of Medicine (Faculty Division Ahus), University of Oslo, Oslo, Norway</addr-line></aff><aff id="aff84"><label>84</label><addr-line>Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, United States of America</addr-line></aff><aff id="aff85"><label>85</label><addr-line>Stanford University School of Medicine, Stanford, California, United States of America</addr-line></aff><aff id="aff86"><label>86</label><addr-line>Deptartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America</addr-line></aff><aff id="aff87"><label>87</label><addr-line>Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland</addr-line></aff><aff id="aff88"><label>88</label><addr-line>Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland</addr-line></aff><aff id="aff89"><label>89</label><addr-line>Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland</addr-line></aff><aff id="aff90"><label>90</label><addr-line>Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</addr-line></aff><aff id="aff91"><label>91</label><addr-line>Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</addr-line></aff><aff id="aff92"><label>92</label><addr-line>Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</addr-line></aff><aff id="aff93"><label>93</label><addr-line>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</addr-line></aff><aff id="aff94"><label>94</label><addr-line>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada</addr-line></aff><aff id="aff95"><label>95</label><addr-line>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada</addr-line></aff><aff id="aff96"><label>96</label><addr-line>Department of Laboratory Medicine, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Ontario, Canada</addr-line></aff><aff id="aff97"><label>97</label><addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America</addr-line></aff><aff id="aff98"><label>98</label><addr-line>Sections of Epidemiology and Genetics, Institute of Cancer Research and Breakthrough Breast Cancer Research Centre, London, United Kingdom</addr-line></aff><aff id="aff99"><label>99</label><addr-line>Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw, Poland</addr-line></aff><aff id="aff100"><label>100</label><addr-line>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></aff><aff id="aff101"><label>101</label><addr-line>Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></aff><aff id="aff102"><label>102</label><addr-line>Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></aff><aff id="aff103"><label>103</label><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line></aff><aff id="aff104"><label>104</label><addr-line>Population Genetics, Genome Institute of Singapore, Singapore, Republic of Singapore</addr-line></aff><aff id="aff105"><label>105</label><addr-line>Institute for Cancer Studies, Department of Oncology, University of Sheffield, Sheffield, United Kingdom</addr-line></aff><aff id="aff106"><label>106</label><addr-line>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom</addr-line></aff><aff id="aff107"><label>107</label><addr-line>Academic Unit of Surgical Oncology, Department of Oncology, University of Sheffield, Sheffield, United Kingdom</addr-line></aff><aff id="aff108"><label>108</label><addr-line>Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></aff><aff id="aff109"><label>109</label><addr-line>Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</addr-line></aff><aff id="aff110"><label>110</label><addr-line>Department of Surgery, Seoul National University College of Medicine, Seoul, Korea</addr-line></aff><aff id="aff111"><label>111</label><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line></aff><aff id="aff112"><label>112</label><addr-line>Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland</addr-line></aff><aff id="aff113"><label>113</label><addr-line>Molecular Epidemiology Unit, National Cancer Institute, Bangkok, Thailand</addr-line></aff><aff id="aff114"><label>114</label><addr-line>Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France</addr-line></aff><aff id="aff115"><label>115</label><addr-line>Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</addr-line></aff><aff id="aff116"><label>116</label><addr-line>Taiwan Biobank, Taipei, Taiwan</addr-line></aff><aff id="aff117"><label>117</label><addr-line>Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan</addr-line></aff><aff id="aff118"><label>118</label><addr-line>Cancer Center and Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan</addr-line></aff><aff id="aff119"><label>119</label><addr-line>The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</addr-line></aff><aff id="aff120"><label>120</label><addr-line>Section of Epidemiology, Institute of Cancer Research, Sutton, Surrey, United Kingdom</addr-line></aff><aff id="aff121"><label>121</label><addr-line>University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, United States of America</addr-line></aff><aff id="aff122"><label>122</label><addr-line>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America</addr-line></aff><aff id="aff123"><label>123</label><addr-line>Department of Community & Family Medicine, Department of Pediatrics, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, New Hampshire, United States of America</addr-line></aff><aff id="aff124"><label>124</label><addr-line>Division of Population Sciences, Moffitt Cancer Center & Research Institute, Tampa, Florida, United States of America</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Chan</surname><given-names>Kelvin Yuen Kwong</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>Tsan Yuk Hospital, Hospital Authority, China</addr-line></aff><author-notes><corresp id="cor1">* E-mail: <email>rebecca.hein@uk-koeln.de</email> (RH); <email>alisond@srl.cam.ac.uk</email> (AD)</corresp><fn fn-type="conflict"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con"><p>Analyzed the data: RH MM ACA JCC DFE AMD. Wrote the paper: RH ACA JCC DFE AMD. Participated in Design/Recruitment/PhenotypeCollection: KRM AL SR PP PF AH ABE MWB NJ IdSS JP ES IT MK NM SEB BGN HF JIAP MPZ JB HAC AZ LB CCD HB HM FM AS CS BB VA CS SS CRB HB UH YDK JCC VK VMK GCT DFJ FJC JEO XW ZF GGG LB CAM KO MR MMG JV VK ALBD EMJ RW KP AM SS CRB RKS AJV MG JDF JL MES AC MWRR MG PDPP DK KYY DYN CYS JCY HAC AZ MKH DFE AMD. Participated in Genotyping/Data Quality Control: MM KRM ABE OF ES IT SEB SWG AM JH JB ZF LB CAM GGA VK AM MGC PH KH KC JL AC SA MG HMH MFH MKH. Managed the database: MH JM. Revised the manuscript critically and approved the version of the manuscript to be published: All authors.</p></fn></author-notes><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>7</day><month>8</month><year>2012</year></pub-date><volume>7</volume><issue>8</issue><elocation-id>e42380</elocation-id><history><date date-type="received"><day>26</day><month>3</month><year>2012</year></date><date date-type="accepted"><day>4</day><month>7</month><year>2012</year></date></history><permissions><copyright-year>2012</copyright-year><copyright-holder>Hein et al</copyright-holder><license><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><abstract><p>The 6q25.1 locus was first identified via a genome-wide association study (GWAS) in Chinese women and marked by single nucleotide polymorphism (SNP) rs2046210, approximately 180 Kb upstream of <italic>ESR1</italic>. There have been conflicting reports about the association of this locus with breast cancer in Europeans, and a GWAS in Europeans identified a different SNP, tagged here by rs12662670. We examined the associations of both SNPs in up to 61,689 cases and 58,822 controls from forty-four studies collaborating in the Breast Cancer Association Consortium, of which four studies were of Asian and 39 of European descent. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). Case-only analyses were used to compare SNP effects in Estrogen Receptor positive (ER+) versus negative (ER<bold>−</bold>) tumours. Models including both SNPs were fitted to investigate whether the SNP effects were independent. Both SNPs are significantly associated with breast cancer risk in both ethnic groups. Per-allele ORs are higher in Asian than in European studies [rs2046210: OR (A/G) = 1.36 (95% CI 1.26–1.48), p = 7.6×10<sup>−14</sup> in Asians and 1.09 (95% CI 1.07–1.11), p = 6.8×10<sup>−18</sup> in Europeans. rs12662670: OR (G/T) = 1.29 (95% CI 1.19–1.41), p = 1.2×10<sup>−9</sup> in Asians and 1.12 (95% CI 1.08–1.17), p = 3.8×10<sup>−9</sup> in Europeans]. SNP rs2046210 is associated with a significantly greater risk of ER− than ER+ tumours in Europeans [OR (ER−) = 1.20 (95% CI 1.15–1.25), p = 1.8×10<sup>−17</sup> versus OR (ER+) = 1.07 (95% CI 1.04–1.1), p = 1.3×10<sup>−7</sup>, p<sub>heterogeneity</sub> = 5.1×10<sup>−6</sup>]. In these Asian studies, by contrast, there is no clear evidence of a differential association by tumour receptor status. Each SNP is associated with risk after adjustment for the other SNP. These results suggest the presence of two variants at 6q25.1 each independently associated with breast cancer risk in Asians and in Europeans. Of these two, the one tagged by rs2046210 is associated with a greater risk of ER− tumours.</p></abstract><funding-group><funding-statement>This work was partly supported by the European Community’s Seventh Framework Programme (COGS; <ext-link ext-link-type="uri" xlink:href="http://cogseu.org/">http://cogseu.org/</ext-link>) [grant agreement number 223175, grant number HEALTH-F2-2009-223175]. The Breast Cancer Association Consortium (BCAC) is funded by Cancer Research-UK (<ext-link ext-link-type="uri" xlink:href="http://science.cancerresearchuk.org/">http://science.cancerresearchuk.org/</ext-link>) [C1287/A10118 and C1287/A12014]. Meetings of the BCAC have been funded by the European Union COST programme (<ext-link ext-link-type="uri" xlink:href="http://www.srl.cam.ac.uk/consortia/cost/index.html">http://www.srl.cam.ac.uk/consortia/cost/index.html</ext-link>) [BM0606]. D.F.E. is a Principal Research Fellow of Cancer Research-UK. A.C.A. is a Cancer Research-UK Senior Cancer Research Fellow. A.M.D has been funded by Cancer Research- UK [C8197/A10865] and The Joseph Mitchell Trust. The Australian Breast Cancer Family Study (ABCFS) and Northern California Breast Cancer Family Registry (NC-BCFR) work was supported by the United States National Cancer Institute, National Institutes of Health (NIH) [RFA-CA-06-503]; and through cooperative agreements with members of the Breast Cancer Family Registry (BCFR); and Principal Investigators, including Cancer Care Ontario [U01 CA69467]; Northern California Cancer Center [U01 CA69417]; University of Melbourne [U01 CA69638]. Samples from the NC-BCFR were processed and distributed by the Coriell Institute for Medical Research. The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centers in the BCFR, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government or the BCFR. The ABCFS was also supported by the National Health and Medical Research Council of Australia; the New South Wales Cancer Council; the Victorian Health Promotion Foundation (Australia); and the Victorian Breast Cancer Research Consortium. J.L.H. is a National Health and Medical Research Council (NHMRC) Australia Fellow and a Victorian Breast Cancer Research Consortium Group Leader. M.C.S. is a NHMRC Senior Research Fellow and a Victorian Breast Cancer Research Consortium Group Leader. The Amsterdam Breast Cancer Study (ABCS) study was supported by the Dutch Cancer Society [NKI 2001–2423; 2007–3839]; and the Dutch National Genomics Initiative. The Asian Cancer Program (ACP) study was supported by the Breast Cancer Research Trust. The Bavarian Breast Cancer Cases and Controls (BBCC) study was partly supported by ELAN-Fond of the University Hospital of Erlangen. The British Breast Cancer Study (BBCS) study is supported by Cancer Research UK; and Breakthrough Breast Cancer; and acknowledges National Health Service (NHS) funding to the National Institute for Health Research (NIHR) Biomedical Research Centre; and the National Cancer Research Network (NCRN). Breast Cancer in Galway Genetic Study (BIGGS) is supported by National Institute for Health Research (NIHR) Comprehensive Biomedical Research Centre [to E.S.]; Guy’s & St. Thomas’ National Health Service Foundation Trust in partnership with King’s College London [to E.S.]; and the Oxford Biomedical Research Centre [to I.T.]. The Breast Cancer Study of the University Clinic Heidelberg (BSUCH) study was supported by the Dietmar-Hopp Foundation; and the Helmholtz Society. The CECILE Breast Cancer Study (CECILE) study was supported by Fondation de France (2007), French National Institute of Cancer [INCa grant 2007, 2008, 2009]; French Agency for Environmental and Occupational Health [ANSES (ex–AFSSET) grant 2008 and 2009]; the French League Against Cancer; and National Research Agency (ANR). The Copenhagen General Population Study (CGPS) was supported by the Chief Physician Johan Boserup and Lise Boserup Fund; the Danish Medical Research Council; and Herlev Hospital. The Spanish National Cancer Centre Breast Cancer Study (CNIO-BCS) was supported by the Genome Spain Foundation; the Red Temática de Investigación Cooperativa en Cáncer and grants from the Asociación Española Contra el Cáncer and the Fondo de Investigación Sanitario [PI081120 to J.B., PI081583 to R.L.M.]. The California Teachers Study (CTS) was supported by the California Breast Cancer Act of 1993; National Institutes of Health [R01 CA77398]; the Lon V Smith Foundation [LVS39420]; and the California Breast Cancer Research Fund [contract 97–10500]. Collection of cancer incidence data used in this study was supported by the California Department of Public Health as part of the statewide cancer reporting program mandated by California Health and Safety Code Section 103885. The ESTHER Breast Cancer Study (ESTHER) study was supported by a grant from the Baden Württemberg Ministry of Science, Research and Arts. Additional cases were recruited in the context of the VERDI study, which was supported by a grant from the German Cancer Aid (Deutsche Krebshilfe). The ICR Familial Breast Cancer Study (FBCS) is supported by funds from Cancer Research UK [C8620/A8372; C8620/A8857]; a US Military Acquisition (ACQ) Activity, Era of Hope Award [W81XWH-05-1-0204]; the Institute of Cancer Research (UK) a Medical Research Council (UK) Clinical Research Fellowship [to C.T.]. The FBCS acknowledges National Health Service (NHS) funding to the Royal Marsden/Institute of Cancer Research, National Institute for Health Research (NIHR) Specialist Cancer. The German Consortium for Hereditary Breast & Ovarian Cancer (GC-HBOC) was supported by Deutsche Krebshilfe [107054]; the Center of Molecular Medicine, Cologne; the Helmholtz society; and the Dietmar Hopp Foundation [to B.B.]. The Gene Environment Interaction and Breast Cancer in Germany (GENICA) network was supported by the Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, and the University of Tübingen, Germany [to C.J. and H.B.]; the Department of Internal Medicine, Evangelische Kliniken Bonn GmbH, Johanniter Krankenhaus, Bonn, Germany [to Y.D.K. and C.B.]; the Institute of Pathology, University of Bonn, Bonn, Germany [to HP.F.]; Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany [to U.H.]; the Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum, Germany [to T.B., B.P., S.R., A.S. and V.H.]. The Genetic Epidemiology Study of Breast Cancer by Age 50 (GESBC) was supported by the Deutsche Krebshilfe e. V. [70492]; and genotyping in part by the state of Baden-Württemberg through the Medical Faculty of the University of Ulm [P.685]. The Hannover Breast Cancer Study (HABCS) study was supported by an intramural grant from Hannover Medical School; and by a grant from the German Research Foundation [DFG, Do761/2-1]. The Helsinki Breast Cancer Study (HEBCS) study has been financially supported by the Helsinki University Central Hospital Research Fund, Academy of Finland [132473]; the Finnish Cancer Society; and the Sigrid Juselius Foundation. The Hannover-Minsk Breast Cancer Study (HMBCS) was supported by short-term fellowships from the German Academic Exchange Program [to N.B.]; and the Friends of Hannover Medical School [to N.B.]. The Hannover-Ufa Breast Cancer Study (HUBCS) was supported by a grant from the German Federal Ministry of Research and Education [RUS08/017]. The Karolinska Breast Cancer Study (KARBAC) was supported by the Swedish Cancer Society and the Stockholm Cancer Society. The Kuopio Breast Cancer Project (KBCP) was financially supported by the special Government Funding (EVO) of Kuopio University Hospital grants, Cancer Fund of North Savo; the Finnish Cancer Organizations; the Academy of Finland; and by the strategic funding of the University of Eastern Finland. Kathleen Cuningham Foundation Consortium for research into Familial Breast Cancer/Australian Ovarian Cancer Study (KConFab/AOCS) is supported by grants from the National Breast Cancer Foundation; the National Health and Medical Research Council (NHMRC); the Queensland Cancer Fund; the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia; and the Cancer Foundation of Western Australia. The kConFab Clinical Follow Up Study was funded by the NHMRC [145684; 288704; 454508]. Financial support for the AOCS was provided by the United States Army Medical Research and Materiel Command [DAMD17-01-1-0729]; the Cancer Council of Tasmania and Cancer Foundation of Western Australia; and the NHMRC [199600]. G.C.T. and P.W. are supported by the NHMRC. Leuven Multidisciplinary Breast Centre (LMBC) is supported by the ‘Stichting tegen Kanker’ [232–2008; 196–2010]. The Mammary Carcinoma Risk Factor Investigation (MARIE) study was supported by the Deutsche Krebshilfe e.V. [70–2892-BR I]; the Hamburg Cancer Society; the German Cancer Research Center; and the genotype work in part by the Federal Ministry of Education and Research (BMBF) Germany [01KH0402]. Milan Breast Cancer Study Group (MBCSG) was supported by grants from Ministero della Salute (Extraordinary National Cancer Program 2006 “Alleanza contro il Cancro”, and “Progetto Tumori Femminili”) [to P.R.]; Ministero dell’Universita’ e Ricerca (RBLAO3-BETH) [to P.R.]; Fondazione Italiana per la Ricerca
sul Cancro (Special Project “Hereditary tumors”); Associazione Italiana per la Ricerca sul Cancro (4017) [to P.P.]; and by funds from Italian citizens who allocated the 5/1000 share of their tax payment in support of the Fondazione IRCCS Istituto Nazionale Tumori, according to Italian laws (INT-Institutional strategic projects “5×1000”). The Mayo Clinic Breast Cancer Study (MCBCS) was supported by National Institutes of Health grants [R01CA122340; R01 CA128978]; and a Specialized Program of Research Excellence (SPORE) in Breast Cancer [CA116201]. Melbourne Collaborative Cohort Study (MCCS) cohort recruitment was funded by VicHealth; and Cancer Council Victoria. The MCCS was further supported by Australian National Health and Medical Research Council (NHMRC) grants [209057; 251553; 504711]; and by infrastructure provided by Cancer Council Victoria. The Memorial Sloan-Kettering Cancer Center (MSKCC) was supported by the Breast Cancer Research Foundation; the Sharon Levine Corzine Fund; the Niehaus Cancer Research Initiative; the Andrew Sabin Family Fund; the Charles Krasne Research Fund; and the Norman and Carol Stone Research Initiative. The Norwegian Breast Cancer Study (NBCS) was supported by grants from the Norwegian Research council [155218/V40, 175240/S10 to A.L.B.D.; FUGE-NFR 181600/V11 to V.N.K.]; and a Swizz Bridge Award [to A.L.B.D.]. The Oulu Breast Cancer Study (OBCS) was supported by research grants from the Finnish Cancer Foundation; the Sigrid Juselius Foundation; the Academy of Finland; the University of Oulu; and the Oulu University Hospital. The Ontario Familial Breast Cancer Registry (OFBCR) work was supported by the National Cancer Institute, National Institutes of Health [RFA # CA- 06–503]; and through cooperative agreements with members of the Breast Cancer Family Registry (BCFR); and Principal Investigators, including Cancer Care Ontario [U01 CA69467]; Northern California Cancer Center [U01 CA69417]; and University of Melbourne [U01 CA69638]; and by Cancer Care Ontario. The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centers in the BCFR, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government or the BCFR. The National Cancer Institute Polish Breast Cancer Study (PBCS) was supported by Intramural Research Funds of the National Cancer Institute, Department of Health and Human Services, USA. The Rotterdam Breast Cancer Study (RBCS) was funded by the Dutch Cancer Society [DDHK 2004–3124; DDHK 2009–4318]. The Singapore and Sweden Breast Cancer Study (SASBAC) was funded by the Märit and Hans Rausing Initiative Against Breast Cancer; the Agency for Science, Technology and Research of Singapore (ASTAR); the United States National Institutes of Health (NIH); and the Susan G. Komen Breast Cancer Foundation. The Sheffield Breast Cancer Study (SBCS) was funded by Yorkshire Cancer Research; and the Breast Cancer Campaign. The Study of Epidemiology and Risk factors in Cancer Heredity (SEARCH) study is funded by a programme grant from Cancer Research UK [C490/A11021] and laboratory infrastructure by [C8197/A10123]. The Seoul Breast Cancer Study (SEBCS) was supported by the Korea Health 21 R&D Project [AO30001], Ministry of Health and Welfare, Republic of Korea. The IHCC-Szczecin Breast Cancer Study (SZBCS) was supported by Grant PBZ_KBN_122/P05/2004; and the Polish Foundation of Science [to K.J.]. Katarzyna Jaworska is a fellow of International PhD program, Postgraduate School of Molecular Medicine, Warsaw Medical University. The International Agency for Research on Cancer-Thai Breast Cancer Study (TBCS) was funded by The National Cancer Institute Thailand. The Taiwanese Breast Cancer Study (TWBCS) is supported by the Taiwan Biobank project of the Institute of Biomedical Sciences, Academia Sinica, Taiwan. The University of California, Irvine, Breast Cancer Study (UCIBCS) component of this research was supported by the National Institute of Health [CA58860; CA92044]; and the Lon V Smith Foundation [LVS39420]. The UK Breakthrough Generations Study (UKBGS) is funded by Breakthrough Breast Cancer. The US Three State Study (US3SS) study was supported by Massachusetts [R01CA47305 to K.M.E.]; Wisconsin [R01 CA47147 to P.A.N.]; and New Hampshire [R01CA69664 to L. T.-E.] centers; and Intramural Research Funds of the National Cancer Institute, Department of Health and Human Services, USA. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><page-count count="14"></page-count></counts></article-meta></front><body><sec id="s1"><title>Introduction</title><p>A genome-wide association study (GWAS) in Chinese women by Zheng et al. <xref ref-type="bibr" rid="pone.0042380-Zheng1">[1]</xref> identified a novel breast cancer susceptibility locus at 6q25.1. The most strongly associated single nucleotide polymorphism (SNP) was rs2046210, with an estimated Odds ratio (OR) [per-allele A/G] = 1.29 (95% confidence interval (CI) 1.21–1.37, p = 10<sup>−15</sup>). SNP rs2046210 did not show a clear association in GWAS carried out in women of European ancestry, and replication studies indicated its effect, if any, was weaker in Europeans [OR (per allele A/G) = 1.04 (95% CI 0.99–1.08), p = 0.09 in a combined analysis of European studies <xref ref-type="bibr" rid="pone.0042380-Stacey1">[2]</xref>]. More recent studies in European women suggested stronger associations with other SNPs in the region: Turnbull et al. <xref ref-type="bibr" rid="pone.0042380-Turnbull1">[3]</xref> found the most significantly associated SNP to be rs3757318, which is only weakly correlated with rs2046210 in Europeans (r<sup>2</sup> = 0.09 from in HapMap2 CEU), while Stacey et al. <xref ref-type="bibr" rid="pone.0042380-Stacey1">[2]</xref> suggested that SNPs closer to <italic>ESR1</italic> may be more strongly associated. It is as yet unclear whether this difference in breast cancer associated SNPs between Asians and Europeans indicates the presence of a single or multiple causative variant(s) at this locus. If there is only one, it is unlikely to be highly correlated with the best tags identified from either the Asian or European GWAS and could potentially be a common variant with a small effect or a rarer one with a larger effect on breast cancer risk.</p><p>In this, by far the largest study to date, we investigate associations with SNP rs2046210, as well as with SNP rs12662670 in forty-four case-control studies within the Breast Cancer Association Consortium (BCAC). These two SNPs have been genotyped in a total of 120,511 female subjects, of which 110,265 subjects are of European ancestry and 8,559 are Asian. SNP rs2046210 is the best tag from the original Asian GWAS <xref ref-type="bibr" rid="pone.0042380-Zheng1">[1]</xref> and SNP rs12662670 is an easier to genotype surrogate for SNP rs3757318 - the best tag SNP at the 6q25.1 locus from a European GWAS <xref ref-type="bibr" rid="pone.0042380-Turnbull1">[3]</xref>. Our aims were to compare the effects of these tags in well-powered studies of both Asian and European ancestry and to test if these known SNP associations are shared by the different ethnic groups. We have been successful in achieving these aims and our analyses provide additional insights into the nature of this locus.</p></sec><sec sec-type="materials|methods" id="s2"><title>Materials and Methods</title><sec id="s2a"><title>Ethics Statement</title><p>Approval of the studies was obtained from the ethics committees listed in <xref ref-type="supplementary-material" rid="pone.0042380.s001">Table S1</xref>. All studies conform to the Declaration of Helsinki and all study participants gave written informed consent.</p></sec><sec id="s2b"><title>Study Populations</title><p>Data from forty-five BCAC case-control studies from Australia, Europe, North America, and South-East Asia were available for inclusion in this analysis (see <bold><xref ref-type="supplementary-material" rid="pone.0042380.s001">Table S1</xref></bold> for a description of the individual studies). To be eligible for BCAC, studies needed to include at least 500 cases of invasive breast cancer and 500 controls, with DNA samples available for genotyping. The controls needed to be broadly from the same population as the cases (<ext-link ext-link-type="uri" xlink:href="http://www.srl.cam.ac.uk/consortia/bcac/about/about.html">http://www.srl.cam.ac.uk/consortia/bcac/about/about.html</ext-link>). Some studies selected cases preferentially on the basis of age and/or family history.</p><p>All studies provided information on disease status (58,822 controls/62,061 invasive cases/2,769 <italic>in-situ</italic> cases/1,435 cases of unknown invasiveness), age at diagnosis or interview and ethnicity (Asian/European/other). Forty studies also provided information on estrogen receptor (ER) status for a total of 40,508 cases (9,878 Estrogen receptor negative (ER−)/30,630 Estrogen Receptor positive (ER+)).</p></sec><sec id="s2c"><title>Laboratory Methods</title><p>In most studies SNPs were assayed by Taqman™ (Applied Biosystems, Foster City, USA). Primers, probes and master mix were ordered in a single batch and alliquots shipped to each study. Reactions were performed according to manufacturer’s instructions, using the following thermal cycling profile 95°C for 10 mins followed by: [92°C for 15 secs, 60°C for 1 min] for 40–60 cycles.</p><p>SNP rs12662670 was chosen as the most easily assayable surrogate for the best European GWAS hit, rs3757318, for which no working Taqman™ assay could be designed. These two SNPs are correlated at r<sup>2</sup> = 0.89 in the European samples used in Turnbull et al. <xref ref-type="bibr" rid="pone.0042380-Turnbull1">[3]</xref> although the correlations in populations of Asian ancestry are somewhat weaker (r<sup>2</sup> = 0.72 and r<sup>2</sup> = 0.66 in HapMap2 JPT and CHB samples, respectively).</p><p>The primer and probe sequences used were:</p><p>For <bold>SNP rs2046210</bold></p><p>Forward primerTGCCTCAACTGTCTTGTGAATCTTT</p><p>Reverse primerCTACTGTAGAATCATTTTCCTCACACATACA</p><p>G allele probeVIC <named-content content-type="gene">ACAGTCACATACGCATCTA</named-content></p><p>A allele probe FAM <named-content content-type="gene">CAGTCACATACACATCTA</named-content></p><p>For <bold>SNP rs12662670</bold></p><p>Forward primerCTAACGAAGGCAGAGCAAAAAGAAA</p><p>Reverse primerCACACATGCATGACACGTAAATCTT</p><p>T allele probeVIC <named-content content-type="gene">ATTAAATTCTTGTAAGTTTCC</named-content></p><p>G allele probe FAM <named-content content-type="gene">AATTCTTGTCAGTTTCC</named-content></p><p>Four studies (ACP, GESBC, kConFab/AOCS and MARIE) used the Sequenom iPLEX MassARRAY™ system (Sequenom, San Diego, CA, USA) with oligonucleotide design performed using MassARRAY Assay Design software (version 3.1).</p><p>SNPs were genotyped in three different BCAC genotyping phases along with other SNPs of interest to the consortium (see <bold><xref ref-type="supplementary-material" rid="pone.0042380.s002">Tables S2a and S2b</xref></bold> for information on the respective phases for SNPs rs2046210 and rs12662670). All studies followed standard quality control guidelines (for details see <ext-link ext-link-type="uri" xlink:href="http://www.srl.cam.ac.uk/consortia/bcac/about/about.html">http://www.srl.cam.ac.uk/consortia/bcac/about/about.html</ext-link>). Data were excluded for any sample that failed genotyping for >20% of the SNPs typed in a given phase of genotyping. All study data were excluded for any SNP with overall call rate <95% or duplicate concordance <94% (based on at least 2% of samples in each study being genotyped in duplicate) or departure of genotype distribution from Hardy-Weinberg equilibrium in controls (p<0.005). In addition, all genotyping centres assayed an identical plate of 80 control DNA samples (referred to as the Coriell plate; which also included 14 internal duplicates) and had to achieve call rates and duplicate concordance >98% in order for their data to be included. Data for both SNPs from one study (NBCS) were excluded from further analyses after quality control rules were applied. Quality control data for the individual studies are shown in <bold><xref ref-type="supplementary-material" rid="pone.0042380.s002">Tables S2a and S2b</xref></bold>. Thus, for SNP rs2046210 forty out of forty-one assayed studies (56,607 cases/49,559 controls), and for SNP rs12662670 thirty-three out of thirty-four assayed studies (47,251 cases/40,161 controls) were included in the statistical analysis.</p></sec><sec id="s2d"><title>Statistical Analyses</title><p>ORs were estimated using logistic regression. In order to provide reliable estimates of effect sizes, study-specific effect estimates of ORs were derived only for those studies that provided at least 100 cases and controls for the respective (sub-) group of interest.</p><p>The primary analysis estimated ORs for the main effect of the SNP, adjusted for the studies that provided data for the respective analysis (i.e. S-1 indicator variables were entered the logistic regression model, where S was number of studies that provided data for the respective analysis). ORs adjusted for both study and age were essentially identical and we did not therefore present the age-adjusted analyses. Per allele ORs were estimated under the assumption of a log-additive mode of inheritance, i.e. the SNP was coded according to the number of minor alleles 0, 1 or 2. Additionally, ORs by genotype were calculated, i.e. two indicator variables indicating the presence of the heterozygous genotype and the genotype homozygous for the minor allele, respectively, were entered the model. The primary p-values were derived by means of a Wald-Test assuming a log-additive mode of inheritance (one degree of freedom). Following Laird and Mosteller, heterogeneity of per allele ORs between studies was assessed by the p-value derived from the Q statistic <xref ref-type="bibr" rid="pone.0042380-Laird1">[4]</xref> and using I<sup>2</sup>. Tests were two-sided.</p><p>Genetic main effects by ER status were estimated using case-control logistic regression and restricting the case sample to ER+ or ER− cases, respectively. To test for significant differences between main effects of rs2046210 or rs12662670 in ER+ versus ER− cases, logistic regression analyses were conducted in cases only. In these case-only analyses, the binary ER status was the outcome/dependent variable and the respective SNP and the indicator variables representing the studies were the independent variables.</p><p>Variation in OR by age was evaluated by testing for an interaction between age-group (<40, 40 to 49, 50 to 59, ≥60) and SNP, separately for each subgroup defined by ethnicity and ER status. Thus, the multiplicative SNP by age-group interaction term entered the model in addition to the main effect terms for SNP, age-group and study.</p><p>To investigate whether the association with breast cancer risk could be explained by one SNP or whether both SNPs had independent effects on disease risk, we fitted logistic regression models which included both SNPs, in addition to indicator variables for the studies, as independent variables in the model. Analyses were carried out separately for Europeans and Asians and for ER− versus ER+ cases and controls. Additionally, haplotype analyses were performed using logistic regression models that included the estimated two-marker haplotypes (coded according to a log-additive model) except for the reference haplotype (i.e., the most frequent haplotype) and the indicator variables for study. Haplotypes were estimated using the expectation-maximization algorithm.</p><p>All analyses, were performed using R version 2.11.0 <xref ref-type="bibr" rid="pone.0042380-R1">[5]</xref> and the R packages meta, rmeta and haplo.stats.</p></sec></sec><sec id="s3"><title>Results</title><p>Key characteristics for each participating study are shown in <bold><xref ref-type="supplementary-material" rid="pone.0042380.s001">Table S1</xref></bold>. In addition to the originally discovered SNP rs2046210, SNP s12662670 was genotyped as a surrogate for the best tag from Turnbull et al. (rs3757318) <xref ref-type="bibr" rid="pone.0042380-Turnbull1">[3]</xref>, for which no working Taqman™ assay could be designed. The genotype distributions by ethnicity and study for SNPs rs2046210 and rs12662670 in cases and controls are given in <bold><xref ref-type="supplementary-material" rid="pone.0042380.s003">Tables S3a and S3b</xref></bold>. The associations of each SNP are presented in <xref ref-type="table" rid="pone-0042380-t001"><bold>Table 1</bold></xref> and as Forest plots in <xref ref-type="fig" rid="pone-0042380-g001"><bold>Figure 1</bold></xref> and <xref ref-type="fig" rid="pone-0042380-g002"><bold>2</bold></xref>, separately for Europeans and Asians. Both SNPs are significantly associated with breast cancer risk in both ethnic groups. However, the per-allele OR associated with the minor A allele of SNP rs2046210 is higher in Asian populations [OR (A/G) = 1.36 (95% CI 1.26–1.48), p = 7.6×10<sup>−14</sup>] than in Europeans [OR (A/G) = 1.09 (95% CI 1.07–1.11), p = 6.8×10<sup>−18</sup>] and this difference is statistically significant [p<sub>heterogeneity</sub> = 1.4×10<sup>−7</sup>]. SNP rs12662670 shows a similar pattern, with a higher OR associated with the minor G allele in Asian studies [OR (G/T) = 1.29 (95% CI 1.19–1.41), p = 1.2×10<sup>−9</sup>] than in Europeans [OR (G/T) = 1.12 (95% CI 1.08–1.17), p = 3.8×10<sup>−9</sup>] and again this difference is statistically significant [p<sub>heterogeneity</sub> = 0.002]. In each case there is no evidence for departure from a log-additive model (a co-dominant mode of inheritance).</p><table-wrap id="pone-0042380-t001" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0042380.t001</object-id><label>Table 1</label><caption><title>Association of rs2046210 and rs12662670 with breast cancer.</title></caption><alternatives><graphic id="pone-0042380-t001-1" xlink:href="pone.0042380.t001"></graphic><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col></colgroup><thead><tr><td align="left" rowspan="1" colspan="1">Ethnicity</td><td align="left" rowspan="1" colspan="1">Number of cases/controls</td><td colspan="3" align="left" rowspan="1">Odds ratio (95% confidence interval)</td><td align="left" rowspan="1" colspan="1">P-value<xref ref-type="table-fn" rid="nt102">a</xref></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">per allele<xref ref-type="table-fn" rid="nt103">b</xref></td><td align="left" rowspan="1" colspan="1">Heterozygote<xref ref-type="table-fn" rid="nt104">c</xref></td><td align="left" rowspan="1" colspan="1">Homozygote<xref ref-type="table-fn" rid="nt104">c</xref></td><td align="left" rowspan="1" colspan="1"></td></tr></thead><tbody><tr><td colspan="6" align="left" rowspan="1"><bold>rs2046210</bold></td></tr><tr><td colspan="6" align="left" rowspan="1">Analyses adjusted for study</td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Overall</italic></td><td align="left" rowspan="1" colspan="1">54,647/49,559</td><td align="left" rowspan="1" colspan="1">1.10 (1.08–1.13)</td><td align="left" rowspan="1" colspan="1">1.11 (1.08–1.14)</td><td align="left" rowspan="1" colspan="1">1.22 (1.17–1.27)</td><td align="left" rowspan="1" colspan="1">3.30×10<sup>−25</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Europeans</italic></td><td align="left" rowspan="1" colspan="1">49,634/46,679</td><td align="left" rowspan="1" colspan="1">1.09 (1.07–1.11)</td><td align="left" rowspan="1" colspan="1">1.09 (1.06–1.12)</td><td align="left" rowspan="1" colspan="1">1.18 (1.13–1.23)</td><td align="left" rowspan="1" colspan="1">6.76×10<sup>−18</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Asians</italic></td><td align="left" rowspan="1" colspan="1">2983/2332</td><td align="left" rowspan="1" colspan="1">1.36 (1.26–1.48)</td><td align="left" rowspan="1" colspan="1">1.39 (1.23–1.56)</td><td align="left" rowspan="1" colspan="1">1.83 (1.54–2.18)</td><td align="left" rowspan="1" colspan="1">7.60×10<sup>−14</sup></td></tr><tr><td colspan="6" align="left" rowspan="1">Analyses adjusted for study and rs12662570</td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Overall</italic></td><td align="left" rowspan="1" colspan="1">40,384/33,750</td><td align="left" rowspan="1" colspan="1">1.08 (1.05–1.11)</td><td align="left" rowspan="1" colspan="1">1.08 (1.05–1.12)</td><td align="left" rowspan="1" colspan="1">1.16 (1.10–1.23)</td><td align="left" rowspan="1" colspan="1">3.06×10<sup>−9</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Europeans</italic></td><td align="left" rowspan="1" colspan="1">36,396/31,105</td><td align="left" rowspan="1" colspan="1">1.08 (1.05–1.11)</td><td align="left" rowspan="1" colspan="1">1.08 (1.04–1.12)</td><td align="left" rowspan="1" colspan="1">1.16 (1.09–1.22)</td><td align="left" rowspan="1" colspan="1">1.78×10<sup>−8</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Asians</italic></td><td align="left" rowspan="1" colspan="1">3416/2420</td><td align="left" rowspan="1" colspan="1">1.17 (1.02–1.36)</td><td align="left" rowspan="1" colspan="1">1.18 (0.99–1.41)</td><td align="left" rowspan="1" colspan="1">1.37 (1.02–1.85)</td><td align="left" rowspan="1" colspan="1">0.028</td></tr><tr><td colspan="6" align="left" rowspan="1"><bold>rs12662670</bold></td></tr><tr><td colspan="6" align="left" rowspan="1">Analyses adjusted for study</td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Overall</italic></td><td align="left" rowspan="1" colspan="1">42,654/40,166</td><td align="left" rowspan="1" colspan="1">1.15 (1.12–1.19)</td><td align="left" rowspan="1" colspan="1">1.15 (1.10–1.19)</td><td align="left" rowspan="1" colspan="1">1.40 (1.23–1.58)</td><td align="left" rowspan="1" colspan="1">2.52×10<sup>−16</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Europeans</italic></td><td align="left" rowspan="1" colspan="1">38,723/37,400</td><td align="left" rowspan="1" colspan="1">1.12 (1.08–1.17)</td><td align="left" rowspan="1" colspan="1">1.13 (1.09–1.18)</td><td align="left" rowspan="1" colspan="1">1.12 (0.94–1.34)</td><td align="left" rowspan="1" colspan="1">3.83×10<sup>−9</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Asians</italic></td><td align="left" rowspan="1" colspan="1">3273/2451</td><td align="left" rowspan="1" colspan="1">1.29 (1.19–1.41)</td><td align="left" rowspan="1" colspan="1">1.24 (1.10–1.39)</td><td align="left" rowspan="1" colspan="1">1.77 (1.46–2.14)</td><td align="left" rowspan="1" colspan="1">1.18×10<sup>−9</sup></td></tr><tr><td colspan="6" align="left" rowspan="1">Analyses adjusted for study and rs2046210</td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Overall</italic></td><td align="left" rowspan="1" colspan="1">40,384/33,750</td><td align="left" rowspan="1" colspan="1">1.10 (1.06–1.15)</td><td align="left" rowspan="1" colspan="1">1.10 (1.05–1.15)</td><td align="left" rowspan="1" colspan="1">1.25 (1.08–1.45)</td><td align="left" rowspan="1" colspan="1">5.86×10<sup>−6</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Europeans</italic></td><td align="left" rowspan="1" colspan="1">36,396/31,105</td><td align="left" rowspan="1" colspan="1">1.07 (1.02–1.12)</td><td align="left" rowspan="1" colspan="1">1.09 (1.03–1.14)</td><td align="left" rowspan="1" colspan="1">1.01 (0.83–1.23)</td><td align="left" rowspan="1" colspan="1">2.91×10<sup>−3</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Asians</italic></td><td align="left" rowspan="1" colspan="1">3416/2420</td><td align="left" rowspan="1" colspan="1">1.21 (1.04–1.40)</td><td align="left" rowspan="1" colspan="1">1.16 (0.97–1.38)</td><td align="left" rowspan="1" colspan="1">1.55 (1.12–2.13)</td><td align="left" rowspan="1" colspan="1">0.012</td></tr></tbody></table></alternatives><table-wrap-foot><fn id="nt101"><label></label><p>Results are presented overall and separately for Europeans and Asians. Pooled analyses adjusted for study only as well as adjusted for rs12662670 or rs2046210, respectively, in addition to study were performed.</p></fn><fn id="nt102"><label>a</label><p>P-value derived from the log-additive model.</p></fn><fn id="nt103"><label>b</label><p>Odds ratio per minor allele (A allele for rs2046210, G allele for rs12662670).</p></fn><fn id="nt104"><label>c</label><p>Odds ratio relative to the major allele homozygous (GT) genotype.</p></fn></table-wrap-foot></table-wrap><fig id="pone-0042380-g001" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0042380.g001</object-id><label>Figure 1</label><caption><title>Association of rs2046210 with breast cancer in Europeans versus Asians.</title></caption><graphic xlink:href="pone.0042380.g001"></graphic></fig><fig id="pone-0042380-g002" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0042380.g002</object-id><label>Figure 2</label><caption><title>Association of rs12662670 with breast cancer in Europeans versus Asians.</title></caption><graphic xlink:href="pone.0042380.g002"></graphic></fig><p>Logistic regression models, which include both SNPs, indicate that the two SNPs are independently associated in both Europeans (p = 1.8×10<sup>−8</sup> for rs2046210, p = 2.9×10<sup>−3</sup> for rs12662670; <xref ref-type="table" rid="pone-0042380-t001"><bold>Table 1</bold></xref>) and Asians (p<italic> = </italic>0.028 for rs2046210, p = 0.012 for rs12662670). In each ethnicity the estimated ORs for each SNP, after adjustment for the other SNP, are of similar magnitudes: For rs2046210 in Europeans OR (A/G) = 1.08 (95% CI 1.05–1.11) and for rs12662670 in Europeans OR (G/T) = 1.07 (95% CI 1.02–1.12). For rs2046210 in Asians OR (A/G) = 1.17 (95% CI 1.02–1.36) and for rs12662670 in Asians OR (G/T) = 1.21 (95% CI 1.04–1.40). Similar effect estimates are also obtained for haplotypes carrying one minor allele though estimates do not reach statistical significance for the very rare haplotype carrying the major (G) allele of rs2046210 along with the minor (G) allele of rs12662670 (<xref ref-type="table" rid="pone-0042380-t002"><bold>Table 2</bold></xref>). Of note, from the four observed haplotypes, effects are strongest and highly statistically significant for the haplotype carrying both minor alleles: In Europeans OR (AG) = 1.16 (95% CI 1.11–1.21). In Asians OR (AG) = 1.42 (95% CI 1.30–1.56).</p><table-wrap id="pone-0042380-t002" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0042380.t002</object-id><label>Table 2</label><caption><title>Association of haplotypes composed of rs2046210 and rs12662670 with breast cancer.</title></caption><alternatives><graphic id="pone-0042380-t002-2" xlink:href="pone.0042380.t002"></graphic><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col></colgroup><thead><tr><td align="left" rowspan="1" colspan="1">Ethnicity</td><td align="left" rowspan="1" colspan="1">Number of cases/controls</td><td align="left" rowspan="1" colspan="1">rs2046210</td><td align="left" rowspan="1" colspan="1">rs12662670</td><td align="left" rowspan="1" colspan="1">Haplotype frequency</td><td align="left" rowspan="1" colspan="1">Odds ratio (95% confidence interval)<xref ref-type="table-fn" rid="nt106">a</xref></td><td align="left" rowspan="1" colspan="1">P-value<xref ref-type="table-fn" rid="nt107">b</xref></td></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1"><italic>Overall</italic></td><td align="left" rowspan="1" colspan="1">40,384/33,750</td><td align="left" rowspan="1" colspan="1">A<xref ref-type="table-fn" rid="nt108">c</xref></td><td align="left" rowspan="1" colspan="1">T</td><td align="left" rowspan="1" colspan="1">0.26</td><td align="left" rowspan="1" colspan="1">1.08 (1.05–1.11)</td><td align="left" rowspan="1" colspan="1">1.55×10<sup>−9</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">G</td><td align="left" rowspan="1" colspan="1">G<xref ref-type="table-fn" rid="nt108">c</xref></td><td align="left" rowspan="1" colspan="1">0.01</td><td align="left" rowspan="1" colspan="1">1.10 (0.95–1.27)</td><td align="left" rowspan="1" colspan="1">0.189</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">A<xref ref-type="table-fn" rid="nt108">c</xref></td><td align="left" rowspan="1" colspan="1">G<xref ref-type="table-fn" rid="nt108">c</xref></td><td align="left" rowspan="1" colspan="1">0.09</td><td align="left" rowspan="1" colspan="1">1.23 (1.18–1.28)</td><td align="left" rowspan="1" colspan="1">2.20×10<sup>−4</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">G<xref ref-type="table-fn" rid="nt109">d</xref></td><td align="left" rowspan="1" colspan="1">T<xref ref-type="table-fn" rid="nt109">d</xref></td><td align="left" rowspan="1" colspan="1">0.64<xref ref-type="table-fn" rid="nt109">d</xref></td><td align="left" rowspan="1" colspan="1">–</td><td align="left" rowspan="1" colspan="1">–</td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Europeans<sup>e</sup></italic></td><td align="left" rowspan="1" colspan="1">36,396/31,105</td><td align="left" rowspan="1" colspan="1">A<xref ref-type="table-fn" rid="nt108">c</xref></td><td align="left" rowspan="1" colspan="1">T</td><td align="left" rowspan="1" colspan="1">0.27</td><td align="left" rowspan="1" colspan="1">1.08 (1.05–1.11)</td><td align="left" rowspan="1" colspan="1">1.59×10<sup>−8</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">G</td><td align="left" rowspan="1" colspan="1">G<xref ref-type="table-fn" rid="nt108">c</xref></td><td align="left" rowspan="1" colspan="1">0.01</td><td align="left" rowspan="1" colspan="1">1.02 (0.86–1.21)</td><td align="left" rowspan="1" colspan="1">0.832</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">A<xref ref-type="table-fn" rid="nt108">c</xref></td><td align="left" rowspan="1" colspan="1">G<xref ref-type="table-fn" rid="nt108">c</xref></td><td align="left" rowspan="1" colspan="1">0.07</td><td align="left" rowspan="1" colspan="1">1.16 (1.11–1.21)</td><td align="left" rowspan="1" colspan="1">4.35×10<sup>−11</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">G<xref ref-type="table-fn" rid="nt109">d</xref></td><td align="left" rowspan="1" colspan="1">T<xref ref-type="table-fn" rid="nt109">d</xref></td><td align="left" rowspan="1" colspan="1">0.65<xref ref-type="table-fn" rid="nt109">d</xref></td><td align="left" rowspan="1" colspan="1">–</td><td align="left" rowspan="1" colspan="1">–</td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Asians<sup>e</sup></italic></td><td align="left" rowspan="1" colspan="1">3416/2420</td><td align="left" rowspan="1" colspan="1">A<xref ref-type="table-fn" rid="nt108">c</xref></td><td align="left" rowspan="1" colspan="1">T</td><td align="left" rowspan="1" colspan="1">0.09</td><td align="left" rowspan="1" colspan="1">1.23 (1.05–1.45)</td><td align="left" rowspan="1" colspan="1">1.15×10<sup>−2</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">G</td><td align="left" rowspan="1" colspan="1">G<xref ref-type="table-fn" rid="nt108">c</xref></td><td align="left" rowspan="1" colspan="1">0.04</td><td align="left" rowspan="1" colspan="1">1.23 (0.94–1.61)</td><td align="left" rowspan="1" colspan="1">0.134</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">A<xref ref-type="table-fn" rid="nt108">c</xref></td><td align="left" rowspan="1" colspan="1">G<xref ref-type="table-fn" rid="nt108">c</xref></td><td align="left" rowspan="1" colspan="1">0.27</td><td align="left" rowspan="1" colspan="1">1.42 (1.30–1.56)</td><td align="left" rowspan="1" colspan="1">4.44×10<sup>−14</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">G<xref ref-type="table-fn" rid="nt109">d</xref></td><td align="left" rowspan="1" colspan="1">T<xref ref-type="table-fn" rid="nt109">d</xref></td><td align="left" rowspan="1" colspan="1">0.60<xref ref-type="table-fn" rid="nt109">d</xref></td><td align="left" rowspan="1" colspan="1">–</td><td align="left" rowspan="1" colspan="1">–</td></tr></tbody></table></alternatives><table-wrap-foot><fn id="nt105"><label></label><p>Results are presented overall and separately for Europeans and Asians. Pooled analyses adjusted for study were performed.</p></fn><fn id="nt106"><label>a</label><p>Odds ratio per haplotype compared to the reference haplotype (i.e., the most frequent haplotype).</p></fn><fn id="nt107"><label>b</label><p>P-value derived from the log-additive model.</p></fn><fn id="nt108"><label>c</label><p>Minor allele.</p></fn><fn id="nt109"><label>d</label><p>Reference haplotype.</p></fn></table-wrap-foot></table-wrap><p>The OR estimates for <italic>in-situ</italic> cancer are similar to those for invasive cancer for both SNPs in Europeans, although, due to small numbers, the effect of rs12662670 on <italic>in-situ</italic> tumours does not reach statistical significance (<bold><xref ref-type="supplementary-material" rid="pone.0042380.s004">Table S4</xref></bold>). For each Asian study, the number of <italic>in-situ</italic> cases is less than 100 and so effect estimates are inaccurate but do not differ from those for invasive cancer (data not shown).</p><p>The associations of these two SNPs with tumour sub-types defined by ER status (ER+ and ER−) were also investigated and are presented in <xref ref-type="table" rid="pone-0042380-t003"><bold>Table 3</bold></xref> and <xref ref-type="fig" rid="pone-0042380-g003"><bold>Figures 3</bold></xref>, <bold><xref ref-type="fig" rid="pone-0042380-g004">4</xref></bold>, <xref ref-type="fig" rid="pone-0042380-g005"><bold>5</bold></xref>, and <xref ref-type="fig" rid="pone-0042380-g006"><bold>6</bold></xref>. In Europeans, SNP rs2046210 is associated with a greater OR for ER− than ER+ tumours: OR (ER−) = 1.20 (95% CI 1.15–1.25), p = 1.8×10<sup>−17</sup> vs. OR (ER+) = 1.07 (95% CI 1.04–1.1), p = 1.3×10<sup>−7</sup>, p<sub>heterogeneity</sub> = 5.1×10<sup>−6</sup>. This difference remains significant after adjustment for rs12662670. A similar, although non-significant, difference is observed in European women for SNP rs12662670 (<xref ref-type="table" rid="pone-0042380-t003"><bold>Table 3</bold></xref>). In the Asian studies, however, there is no clear evidence of a differential association by tumour receptor status for either SNP (<xref ref-type="table" rid="pone-0042380-t003"><bold>Table 3</bold></xref>).</p><table-wrap id="pone-0042380-t003" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0042380.t003</object-id><label>Table 3</label><caption><title>Association of rs2046210 and rs12662670 with risk of ER−<xref ref-type="table-fn" rid="nt111">*</xref>/ER+<xref ref-type="table-fn" rid="nt112">**</xref> breast cancer.</title></caption><alternatives><graphic id="pone-0042380-t003-3" xlink:href="pone.0042380.t003"></graphic><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col></colgroup><thead><tr><td align="left" rowspan="1" colspan="1">Ethnicity</td><td align="left" rowspan="1" colspan="1">Estrogen receptor status</td><td align="left" rowspan="1" colspan="1">Number of cases/controls</td><td align="left" rowspan="1" colspan="1">Odds ratio (95% confidence interval)<xref ref-type="table-fn" rid="nt113">a</xref></td><td align="left" rowspan="1" colspan="1">P-value<xref ref-type="table-fn" rid="nt114">b</xref></td><td align="left" rowspan="1" colspan="1">P-heterogeneity<xref ref-type="table-fn" rid="nt115">c</xref></td></tr></thead><tbody><tr><td colspan="6" align="left" rowspan="1"><bold>rs2046210</bold></td></tr><tr><td colspan="6" align="left" rowspan="1">Analyses adjusted for study</td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Overall</italic></td><td align="left" rowspan="1" colspan="1"><italic>ER</italic>−<xref ref-type="table-fn" rid="nt111">*</xref></td><td align="left" rowspan="1" colspan="1">7126/35,833</td><td align="left" rowspan="1" colspan="1">1.23 (1.18–1.28)</td><td align="left" rowspan="1" colspan="1">6.90×10<sup>−25</sup></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><italic>ER+</italic><xref ref-type="table-fn" rid="nt112">**</xref></td><td align="left" rowspan="1" colspan="1">5914/32,977</td><td align="left" rowspan="1" colspan="1">1.09 (1.06–1.12)</td><td align="left" rowspan="1" colspan="1">1.66×10<sup>−11</sup></td><td align="left" rowspan="1" colspan="1">5.93×10<sup>−7</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Europeans</italic></td><td align="left" rowspan="1" colspan="1"><italic>ER</italic>−<xref ref-type="table-fn" rid="nt111">*</xref></td><td align="left" rowspan="1" colspan="1">807/2334</td><td align="left" rowspan="1" colspan="1">1.20 (1.15–1.25)</td><td align="left" rowspan="1" colspan="1">1.77×10<sup>−17</sup></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><italic>ER+</italic><xref ref-type="table-fn" rid="nt112">**</xref></td><td align="left" rowspan="1" colspan="1">24,596/42,664</td><td align="left" rowspan="1" colspan="1">1.07 (1.04–1.10)</td><td align="left" rowspan="1" colspan="1">1.26×10<sup>−7</sup></td><td align="left" rowspan="1" colspan="1">5.10×10<sup>−6</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Asians</italic></td><td align="left" rowspan="1" colspan="1"><italic>ER</italic>−<xref ref-type="table-fn" rid="nt111">*</xref></td><td align="left" rowspan="1" colspan="1">22,336/39,856</td><td align="left" rowspan="1" colspan="1">1.45 (1.29–1.64)</td><td align="left" rowspan="1" colspan="1">1.70×10<sup>−9</sup></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><italic>ER+</italic><xref ref-type="table-fn" rid="nt112">**</xref></td><td align="left" rowspan="1" colspan="1">1307/2334</td><td align="left" rowspan="1" colspan="1">1.35 (1.22–1.49)</td><td align="left" rowspan="1" colspan="1">1.09×10<sup>−8</sup></td><td align="left" rowspan="1" colspan="1">0.513</td></tr><tr><td colspan="6" align="left" rowspan="1">Analyses adjusted for study and rs12662670</td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Overall</italic></td><td align="left" rowspan="1" colspan="1"><italic>ER</italic>−<xref ref-type="table-fn" rid="nt111">*</xref></td><td align="left" rowspan="1" colspan="1">5526/25,627</td><td align="left" rowspan="1" colspan="1">1.19 (1.13–1.26)</td><td align="left" rowspan="1" colspan="1">1.26×10<sup>−10</sup></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><italic>ER+</italic><xref ref-type="table-fn" rid="nt112">**</xref></td><td align="left" rowspan="1" colspan="1">19,502/32,010</td><td align="left" rowspan="1" colspan="1">1.07 (1.03–1.10)</td><td align="left" rowspan="1" colspan="1">7.26×10<sup>−5</sup></td><td align="left" rowspan="1" colspan="1">1.01×10<sup>−3</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Europeans</italic></td><td align="left" rowspan="1" colspan="1"><italic>ER</italic>−<xref ref-type="table-fn" rid="nt111">*</xref></td><td align="left" rowspan="1" colspan="1">4497/23,090</td><td align="left" rowspan="1" colspan="1">1.20 (1.13–1.26)</td><td align="left" rowspan="1" colspan="1">4.54×10<sup>−10</sup></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><italic>ER+</italic><xref ref-type="table-fn" rid="nt112">**</xref></td><td align="left" rowspan="1" colspan="1">17,653/29,365</td><td align="left" rowspan="1" colspan="1">1.07 (1.03–1.10)</td><td align="left" rowspan="1" colspan="1">2.16×10<sup>−4</sup></td><td align="left" rowspan="1" colspan="1">4.63×10<sup>−4</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Asians</italic></td><td align="left" rowspan="1" colspan="1"><italic>ER</italic>−<xref ref-type="table-fn" rid="nt111">*</xref></td><td align="left" rowspan="1" colspan="1">975/2420</td><td align="left" rowspan="1" colspan="1">1.16 (0.94–1.44)</td><td align="left" rowspan="1" colspan="1">0.169</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><italic>ER+</italic><xref ref-type="table-fn" rid="nt112">**</xref></td><td align="left" rowspan="1" colspan="1">1649/2420</td><td align="left" rowspan="1" colspan="1">1.13 (0.94–1.35)</td><td align="left" rowspan="1" colspan="1">0.194</td><td align="left" rowspan="1" colspan="1">0.777</td></tr><tr><td colspan="6" align="left" rowspan="1"><bold>rs12662670</bold></td></tr><tr><td colspan="6" align="left" rowspan="1">Analyses adjusted for study</td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Overall</italic></td><td align="left" rowspan="1" colspan="1"><italic>ER</italic>−<xref ref-type="table-fn" rid="nt111">*</xref></td><td align="left" rowspan="1" colspan="1">5422/28,201</td><td align="left" rowspan="1" colspan="1">1.23 (1.15–1.32)</td><td align="left" rowspan="1" colspan="1">6.16×10<sup>−9</sup></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><italic>ER+</italic><xref ref-type="table-fn" rid="nt112">**</xref></td><td align="left" rowspan="1" colspan="1">4563/26,198</td><td align="left" rowspan="1" colspan="1">1.14 (1.09–1.19)</td><td align="left" rowspan="1" colspan="1">3.05×10<sup>−8</sup></td><td align="left" rowspan="1" colspan="1">0.074</td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Europeans</italic></td><td align="left" rowspan="1" colspan="1"><italic>ER</italic>−<xref ref-type="table-fn" rid="nt111">*</xref></td><td align="left" rowspan="1" colspan="1">808/1890</td><td align="left" rowspan="1" colspan="1">1.17 (1.08–1.27)</td><td align="left" rowspan="1" colspan="1">1.90×10<sup>−4</sup></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><italic>ER+</italic><xref ref-type="table-fn" rid="nt112">**</xref></td><td align="left" rowspan="1" colspan="1">20,095/34,460</td><td align="left" rowspan="1" colspan="1">1.09 (1.04–1.15)</td><td align="left" rowspan="1" colspan="1">6.08×10<sup>−4</sup></td><td align="left" rowspan="1" colspan="1">0.070</td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Asians</italic></td><td align="left" rowspan="1" colspan="1"><italic>ER</italic>−<xref ref-type="table-fn" rid="nt111">*</xref></td><td align="left" rowspan="1" colspan="1">18,519/32,349</td><td align="left" rowspan="1" colspan="1">1.37 (1.20–1.56)</td><td align="left" rowspan="1" colspan="1">3.30×10<sup>−6</sup></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><italic>ER+</italic><xref ref-type="table-fn" rid="nt112">**</xref></td><td align="left" rowspan="1" colspan="1">1394/1890</td><td align="left" rowspan="1" colspan="1">1.35 (1.21–1.51)</td><td align="left" rowspan="1" colspan="1">1.58×10<sup>−7</sup></td><td align="left" rowspan="1" colspan="1">0.691</td></tr><tr><td colspan="6" align="left" rowspan="1">Analyses adjusted for study and rs2046210</td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Overall</italic></td><td align="left" rowspan="1" colspan="1"><italic>ER</italic>−<xref ref-type="table-fn" rid="nt111">*</xref></td><td align="left" rowspan="1" colspan="1">5526/25,627</td><td align="left" rowspan="1" colspan="1">1.10 (1.01–1.20)</td><td align="left" rowspan="1" colspan="1">0.028</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><italic>ER+</italic><xref ref-type="table-fn" rid="nt112">**</xref></td><td align="left" rowspan="1" colspan="1">19,502/32,010</td><td align="left" rowspan="1" colspan="1">1.09 (1.03–1.15)</td><td align="left" rowspan="1" colspan="1">2.14×10<sup>−3</sup></td><td align="left" rowspan="1" colspan="1">0.87</td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Europeans</italic></td><td align="left" rowspan="1" colspan="1"><italic>ER</italic>−<xref ref-type="table-fn" rid="nt111">*</xref></td><td align="left" rowspan="1" colspan="1">4497/23,090</td><td align="left" rowspan="1" colspan="1">1.03 (0.94–1.14)</td><td align="left" rowspan="1" colspan="1">0.516</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><italic>ER+</italic><xref ref-type="table-fn" rid="nt112">**</xref></td><td align="left" rowspan="1" colspan="1">17,653/29,365</td><td align="left" rowspan="1" colspan="1">1.05 (0.99–1.11)</td><td align="left" rowspan="1" colspan="1">0.110</td><td align="left" rowspan="1" colspan="1">0.92</td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Asians</italic></td><td align="left" rowspan="1" colspan="1"><italic>ER</italic>−<xref ref-type="table-fn" rid="nt111">*</xref></td><td align="left" rowspan="1" colspan="1">975/2420</td><td align="left" rowspan="1" colspan="1">1.33 (1.07–1.65)</td><td align="left" rowspan="1" colspan="1">0.011</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><italic>ER+</italic><xref ref-type="table-fn" rid="nt112">**</xref></td><td align="left" rowspan="1" colspan="1">1649/2420</td><td align="left" rowspan="1" colspan="1">1.26 (1.04–1.52)</td><td align="left" rowspan="1" colspan="1">0.017</td><td align="left" rowspan="1" colspan="1">0.30</td></tr></tbody></table></alternatives><table-wrap-foot><fn id="nt110"><label></label><p>Results are presented overall as well as separately for Europeans and Asians. Pooled analyses adjusted for the studies were performed. A log-additive genetic model was assumed.</p></fn><fn id="nt111"><label>*</label><p>Estrogen receptor negative.</p></fn><fn id="nt112"><label>**</label><p>Estrogen receptor positive.</p></fn><fn id="nt113"><label>a</label><p>Odds ratio per minor allele (A allele for rs2046210, G allele for rs12662670) derived from case-control logistic regression restricted to ER+ or ER− cases, respectively, and the whole control sample.</p></fn><fn id="nt114"><label>b</label><p>P-value derived from the log-additive model derived from case-control logistic regression restricted to ER+ or ER− cases, respectively, and the whole control sample.</p></fn><fn id="nt115"><label>c</label><p>P-value for heterogeneity between estimates of genetic main effects derived from case-only analysis.</p></fn></table-wrap-foot></table-wrap><fig id="pone-0042380-g003" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0042380.g003</object-id><label>Figure 3</label><caption><title>Association of rs2046210 with breast cancer in European ER</title><p>−<bold>*versus ER+*cases and controls.</bold> *Estrogen receptor negative; **Estrogen receptor positive.</p></caption><graphic xlink:href="pone.0042380.g003"></graphic></fig><fig id="pone-0042380-g004" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0042380.g004</object-id><label>Figure 4</label><caption><title>Association of rs2046210 with breast cancer in Asian ER</title><p>−<bold>*versus ER+**cases and controls.</bold> *Estrogen receptor negative; **Estrogen receptor positive.</p></caption><graphic xlink:href="pone.0042380.g004"></graphic></fig><fig id="pone-0042380-g005" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0042380.g005</object-id><label>Figure 5</label><caption><title>Association of rs12662670 with breast cancer in European ER</title><p>−<bold>*versus ER+**cases and controls.</bold> *Estrogen receptor negative; **Estrogen receptor positive.</p></caption><graphic xlink:href="pone.0042380.g005"></graphic></fig><fig id="pone-0042380-g006" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0042380.g006</object-id><label>Figure 6</label><caption><title>Association of rs12662670 with breast cancer in Asian ER</title><p>−<bold>*versus ER+*cases and controls.</bold> *Estrogen receptor negative; **Estrogen receptor positive.</p></caption><graphic xlink:href="pone.0042380.g006"></graphic></fig><p>We further investigated whether the magnitudes of these SNP associations on tumour sub-types differed by age at diagnosis/interview (see <bold><xref ref-type="supplementary-material" rid="pone.0042380.s005">Table S5</xref></bold>). In Asian studies the data are too sparse to give meaningful results. In the combined ethnicities and the European studies alone, the magnitudes of the observed associations are greater in younger women.</p><p>Fourteen of the European studies had been designed to over-sample cases with a family history of breast cancer (see <bold><xref ref-type="supplementary-material" rid="pone.0042380.s001">Table S1</xref></bold>), which could have led to an overestimation of the ORs relative to those expected in a population-based case-control study. However, exclusion of these studies does not materially affect the estimated ORs for either SNP (see <bold><xref ref-type="supplementary-material" rid="pone.0042380.s006">Table S6</xref></bold>).</p></sec><sec id="s4"><title>Discussion</title><p>In this large collaborative study of up to 61,689 cases and 58,822 controls, we demonstrate a highly statistically significant association between the A allele of rs2046210 and increased breast cancer risk in women of both Asian and European ancestry, thus extending the association previously observed in Asian populations. Consistent with previous reports <xref ref-type="bibr" rid="pone.0042380-Zheng1">[1]</xref>–<xref ref-type="bibr" rid="pone.0042380-Turnbull1">[3]</xref>, the effect sizes are significantly greater in Asians than in Europeans. Our study also reveals that the G allele of SNP rs12662670 is significantly associated with increased breast cancer risk in both ethnicities. SNP rs12662670 is used here as surrogate for SNP rs3757318 - the most strongly associated SNP at this locus in the European GWAS described by Turnbull et al. <xref ref-type="bibr" rid="pone.0042380-Turnbull1">[3]</xref>. In addition, and also in contrast to Stacey et al. <xref ref-type="bibr" rid="pone.0042380-Stacey1">[2]</xref>, we find that the OR for rs12662670 is greater in Asians than in Europeans (<xref ref-type="table" rid="pone-0042380-t001"><bold>Table 1</bold></xref>, <xref ref-type="fig" rid="pone-0042380-g001"><bold>Figure 1</bold></xref> and <xref ref-type="fig" rid="pone-0042380-g002"><bold>2</bold></xref>). In contrast to previous reports, our study indicates that both SNPs (rs2046210 and rs12662670) may be independently associated with breast cancer risk – in models including both SNPs, both maintain significant ORs after adjustment for the other. Haplotype analyses result in effect estimates for the AT and GG haplotypes, which carry only one minor allele, very similar to those of the single SNP analyses for the respective minor alleles. Furthermore, haplotype analyses show a clearly stronger effect of the AG haplotype, carrying both minor alleles, compared to the effects of the AT and GG haplotypes, further supporting the hypothesis that there may be two different causative variants, one on each haplotype carrying only one minor allele and both on the haplotype carrying both minor alleles (i.e., the stronger effect of the AG haplotype compared to the AT and GG haplotypes may be explained by the joint effect of the two minor alleles on the AG haplotype). However, the alternative conclusion that a single causative variant may exist that is intermediate between the two SNPs phylogenetically, i.e. on the AG haplotype and on some of the AT haplotypes, cannot yet be completely excluded, since this could also be an explanation for the stronger effect of the AG haplotype compared to the AT and GG haplotypes.</p><p>We also find evidence that SNP rs2046210 is more strongly associated with ER− than ER+ disease in both European and Asian women. In the present study this differential association with receptor status is statistically significant in European studies (and remains after adjustment for rs12662670) but is not quite significant in Asians which may be due to a lack of power attributable to the comparatively small number of Asian individuals involved in our study (<xref ref-type="table" rid="pone-0042380-t003"><bold>Table 3</bold></xref>). However this same SNP had previously been reported to be more strongly associated with ER− tumours in the original Chinese cases <xref ref-type="bibr" rid="pone.0042380-Zheng1">[1]</xref> as well as in a recent replication study in Chinese women <xref ref-type="bibr" rid="pone.0042380-Long1">[6]</xref>. In line with these reports, a meta-analysis (14,231 cases, 10,244 controls) on this SNP-disease association by ER status in Asians, incorporating published results as well as those presented here, reveals a significant difference in OR associated with ER− versus ER+ tumour risk [OR (A/G - ER− ) = 1.37 (95% CI 1.30–1.44), p = 3.7×10<sup>−33</sup> vs. OR (A/G- ER+) = 1.27 (95% CI 1.22–1.34), p = 2.2×10<sup>−24</sup>; p<sub>heterogeneity</sub> = 0.04]. A stronger association of SNP rs2046210 with ER− tumours is also consistent with the report from the Consortium of Modifiers of BRCA1/2 (CIMBA) <xref ref-type="bibr" rid="pone.0042380-Antoniou1">[7]</xref> that the same allele is associated with an increased Hazard Ratio of breast cancer in BRCA1 mutation carriers (who predominantly develop ER− tumours). The CIMBA study also observed that this allele conferred increased Hazard Ratios among younger mutation carriers while we observed similar trends for greater SNP ORs at younger age groups (<bold><xref ref-type="supplementary-material" rid="pone.0042380.s005">Table S5</xref></bold>). By contrast, the CIMBA consortium reported that SNP rs9397435 (the tag they used for rs12662670; r<sup>2</sup> = 0.61, r<sup>2</sup> = 0.50 and r<sup>2</sup> = 0.85 in HapMap2 CEU, JPT and CHB samples, respectively) shows evidence of modification of risk in both BRCA1 and BRCA2 mutation carriers (who mainly develop ER− and ER+ tumours respectively) <xref ref-type="bibr" rid="pone.0042380-Antoniou1">[7]</xref> whilst similarly, we find that SNP rs12662670 is associated with increased risks of both ER− and ER+ tumours.</p><p>Previous fine-scale mapping publications on this locus <xref ref-type="bibr" rid="pone.0042380-Stacey1">[2]</xref>, <xref ref-type="bibr" rid="pone.0042380-Cai1">[8]</xref> have sought a single variant to explain the associations seen with all SNPs in the region: Stacey et al. <xref ref-type="bibr" rid="pone.0042380-Stacey1">[2]</xref> proposed SNP rs9397435 as a possible single causative variant since it was more strongly associated than rs2046210 in women of European, African and Asian ancestry. We are not able to comment on this variant, as it has not been genotyped in BCAC. However, our findings suggest there could be two independent associations at this locus: one, better tagged by SNP rs2046210, predisposing to ER− tumours and the second, better tagged by rs12662670, conferring similar risks of both tumour types. Although physically close, SNPs rs2046210 and rs12662670 are not highly correlated with each other, particularly in Europeans (in BCAC r<sup>2</sup> = 0.12 in Europeans and r<sup>2</sup> = 0.56 in Asians) and all four possible combinations (haplotypes) of these two SNPs clearly exist.</p><p>Examination of linkage disequilibrium plots of the regions surrounding these two SNPs in Europeans (<xref ref-type="fig" rid="pone-0042380-g007"><bold>Figure 7</bold></xref>) reveals little, if any, physical overlap between SNPs highly correlated (r<sup>2</sup>>0.9) with rs2046210 and those with rs12662670. If there were a single causal variant, directly responsible for the associations seen with both SNPs, it would need to be correlated with both SNPs. Such a variant has not been yet identified (e.g. by the 1000 Genomes Project). It would presumably be relatively rare. An alternative, and we think, more plausible, explanation for the pattern of associations may be the existence of two independent causative variants, one correlated with rs2046210 and another correlated with rs12662670. If this is the case, the former variant may be more strongly associated with ER− breast cancer than the latter. The reason why both SNPs confer higher relative risks in Asians than in Europeans is unclear. Within the BCAC studies, ER− tumours are relatively more prevalent among Asian (36%) compared to European cases (23%), but this is not sufficient to explain the higher ORs in Asians, since the effects persist after stratification by ER status. It remains possible that the higher relative risks are due to differential patterns of linkage disequilibrium if the, as yet, unidentified causal variants are not strongly correlated with the SNPs identified to date. These questions may be resolved by comprehensive re-sequencing of this locus and fine scale mapping to identify the causal variant (or variants) responsible for the observed breast cancer risks. One aim of the iCOGS Project <xref ref-type="bibr" rid="pone.0042380-The1">[9]</xref>, which is currently underway, is to address these questions. However it is possible that these observed differences between Asians and Europeans may reflect interactions with lifestyle risk factors or other unlinked genetic loci. Another possible explanation is that the estimated SNP effects in Asians are inflated given the phenomenon known as the “winner’s curse”, i.e. the suboptimal power of the pool of Asian studies (due to the small number of Asian individuals) together with the commonly used requirement for a published association to pass a certain pre-defined p-value threshold may have resulted in biased SNP effect estimates <xref ref-type="bibr" rid="pone.0042380-Ioannidis1">[10]</xref>, <xref ref-type="bibr" rid="pone.0042380-Kraft1">[11]</xref>.</p><fig id="pone-0042380-g007" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0042380.g007</object-id><label>Figure 7</label><caption><title>Linkage disequilibrium blocks in the <italic>ESR1</italic> region.</title><p>Five SNPs tagged (at r2>0.9) by rs12662670 and three by rs2046210 are marked by arrows (dark and light grey respectively); rs12662670 and rs2046210 are marked by stars; rs3757318 and rs9397435 are marked by points; blocks were generated using data from the 1000 Genomes Project and HapMap; blocks include all single nucleotide polymorphisms with a minor allele frequency >0.05. The directions of translation of <italic>ESR1</italic> and <italic>C6orf97</italic> are marked and other genes in the locus are listed.</p></caption><graphic xlink:href="pone.0042380.g007"></graphic></fig><p>Although there are eleven genes within 1 Mb of this locus, attention has focused on the <italic>ESR1</italic> gene, whose transcription start site is located approximately 180 Kb downstream of SNP rs2046210. <italic>ESR1</italic> encodes ERα and has long been implicated in breast carcinogenesis. However, it is possible that the proximity of this SNP to <italic>ESR1</italic> may be providing a false lead – both SNPs (rs2046210 and rs12662670) lie in the flanking region of <italic>C6orf97</italic> and there are numerous other genes in close physical proximity (see <xref ref-type="fig" rid="pone-0042380-g007"><bold>Figure 7</bold></xref>). It is notable however, that SNPs mapping to this region have also been identified in GWAS for bone mineral density – another phenotype in which estradiol metabolism is clearly implicated <xref ref-type="bibr" rid="pone.0042380-Li1">[12]</xref>, <xref ref-type="bibr" rid="pone.0042380-Xie1">[13]</xref>. Furthermore, a recent paper <xref ref-type="bibr" rid="pone.0042380-Dunbier1">[14]</xref> demonstrates that a number of genes, including <italic>ESR1</italic> and <italic>C6orf97</italic> are co-regulated at this locus although the functions of most of these co-regulated genes have not yet been elucidated. The SNP associations, presented here, may provide a basis to explore the biological role of this locus in estrogen signalling and cancer development in more detail.</p><p>Taken together our findings suggest the possibility of the presence of two different causative variants at the 6q25.1 locus and indicate that fine-scale mapping efforts aimed at finding a single variant accounting for associations with both marker SNPs, may not be successful.</p></sec><sec sec-type="supplementary-material" id="s5"><title>Supporting Information</title><supplementary-material content-type="local-data" id="pone.0042380.s001"><label>Table S1</label><caption><p><bold>Characteristics of 45 case-control studies within the Breast Cancer Association Consortium (BCAC).</bold></p><p>(DOC)</p></caption><media xlink:href="pone.0042380.s001.doc" mimetype="application" mime-subtype="msword"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pone.0042380.s002"><label>Table S2</label><caption><p><bold>Characteristics of the study populations genotyped for rs2046210 (a) and rs12662670 (b).</bold></p><p>(DOC)</p></caption><media xlink:href="pone.0042380.s002.doc" mimetype="application" mime-subtype="msword"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pone.0042380.s003"><label>Table S3</label><caption><p><bold>Genotype frequencies of SNP rs2046210 (a) and rs12662670 (b) in the different studies.</bold></p><p>(DOC)</p></caption><media xlink:href="pone.0042380.s003.doc" mimetype="application" mime-subtype="msword"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pone.0042380.s004"><label>Table S4</label><caption><p><bold>Association of rs2046210 and rs12662670 with in-situ/invasive breast cancer.</bold></p><p>(DOC)</p></caption><media xlink:href="pone.0042380.s004.doc" mimetype="application" mime-subtype="msword"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pone.0042380.s005"><label>Table S5</label><caption><p><bold>Association of rs2046210 and rs12662670 with risk of ER</bold>−<bold>*/ER+**breast cancer.</bold></p><p>(DOC)</p></caption><media xlink:href="pone.0042380.s005.doc" mimetype="application" mime-subtype="msword"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pone.0042380.s006"><label>Table S6</label><caption><p><bold>Association of rs2046210 and rs12662670 with breast cancer.</bold></p><p>(DOC)</p></caption><media xlink:href="pone.0042380.s006.doc" mimetype="application" mime-subtype="msword"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material></sec></body><back><ack><p>We thank all the individuals who took part in these studies and all the researchers, clinicians, technicians and administrative staff who have enabled this work to be carried out. In particular we thank Jonathan Morrison (BCAC); Maggie Angelakos, Judi Maskiell and Gillian Dite (ABCFS); Richard van Hien, Sten Cornelissen and the NKI-AVL Family Cancer Clinic (ABCS); all the participants in the Thai Breast Cancer Study within the Asia Cancer Programme (ACP) initiative; special thanks also go to the Thai Ministry of Public Health, doctors and nurses who helped with the data collection process; finally, we would like to thank Ms Sunee Swangsri, our Thai study co-ordinator (ACP); furthermore, we thank Eileen Williams, Elaine Ryder-Mills and Kara Sargus (BBCS); Niall McInerney, Gabrielle Colleran, Andrew Rowan and Angela Jones (BIGGS); Charo Alonso, Tais Moreno, Guillermo Pita, Primitiva Menendez and Anna González-Neira (CNIO-BCS); Hartwig Ziegler, Sonja Wolf and Volker Hermann (ESTHER); all the individuals who took part in these studies and all the researchers, clinicians, technicians and administrative staff who have enabled this work to be carried out; in particular, we thank The Wellcome Trust Case Control Consortium (see the WTCCC website for a full list of contributing investigators) (FBCS); furthermore, we thank Bernd Frank, Rita K. Schmutzler and Claus R. Bartram (GC-HBOC); Christina Justenhoven, Beate Pesch, Thomas Brüning, Volker Harth, Sylvia Rabstein, Christina Baisch and Hans-Peter Fischer (GENICA); Ursula Eilber and Tanya Koehler (GESBC); Johann H. Karstens (HABCS, HMBCS, HUBCS); Kirsimari Aaltonen, Irja Erkkilä (HEBCS); Eija Myöhänen and Helena Kemiläinen (KBCP); Heather Thorne, Eveline Niedermayr, the AOCS Management Group (D Bowtell, G Chenevix-Trench, A deFazio, D Gertig, A Green, P Webb) and the ACS Management Group (A Green, P Parsons, N Hayward, P Webb, D Whiteman) (KConFab/AOCS); Gilian Peuteman, Dominiek Smeets, Thomas Van Brussel and Kathleen Corthouts (LMBC); Tracy Slanger, Elke Mutschelknauss, Ramona Salazar, S. Behrens, R. Birr, W. Busch, U. Eilber, B. Kaspereit, N. Knese and K. Smit (MARIE); Marco Pierotti, Bernard Peissel and Daniela Zaffaroni of the Fondazione IRCCS Istituto Nazionale Tumori, Bernardo Bonanni of the Istituto Europeo di Oncologia, Loris Bernard and the personnel of the Cancer Genetics Testing laboratory at the IFOM-IEO campus (MCBCS); all the people contributing to the MCCS, including the original investigators and the diligent team who recruited the participants and who continue working on follow up; finally, we would like to express our gratitude to the many thousands of Melbourne residents who continue to participate in the study (MCCS); furthermore, we thank the study participants of the MSKCC study (MSKCC); Meeri Otsukka and Kari Mononen for their contribution to OBCS (OBCS); the participants in the Ontario Familial Breast Cancer Registry; Teresa Selander and Nayana Weerasooriya from Cancer Care for their contributions to OFBCR (OFBCR); Michael Stagner and Pei Chao from Information Management Services (Sliver Spring, MD, USA), for data management support (PBCS); Petra Bos, Jannet Blom, Ellen Crepin, Elisabeth Huijskens, Annette Heemskerk and the Erasmus MC Family Cancer Clinic (RBCS); Helen Cramp, Dan Connley, Sabapathy Balasubramanian and Sue Higham for their contribution to patient recruitment and data collection (SBCS); the SEARCH and EPIC teams (SEARCH); Irene Masunaka (UCIBCS); John Hampton from University of Wisconsion and Michael Stagner and Pei Chao from Information Management Services (Sliver Spring, MD, USA), for data management support (US3SS).</p></ack><ref-list><title>References</title><ref id="pone.0042380-Zheng1"><label>1</label><mixed-citation publication-type="journal"><name><surname>Zheng</surname><given-names>W</given-names></name>, <name><surname>Long</surname><given-names>J</given-names></name>, <name><surname>Gao</surname><given-names>YT</given-names></name>, <name><surname>Li</surname><given-names>C</given-names></name>, <name><surname>Zheng</surname><given-names>Y</given-names></name>, <etal>et al</etal> (<year>2009</year>) <article-title>Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1</article-title>. <source><italic>Nat Genet</italic></source><volume>41</volume>: <fpage>324</fpage>–<lpage>328</lpage><pub-id pub-id-type="pmid">19219042</pub-id></mixed-citation></ref><ref id="pone.0042380-Stacey1"><label>2</label><mixed-citation publication-type="journal"><name><surname>Stacey</surname><given-names>SN</given-names></name>, <name><surname>Sulem</surname><given-names>P</given-names></name>, <name><surname>Zanon</surname><given-names>C</given-names></name>, <name><surname>Gudjonsson</surname><given-names>SA</given-names></name>, <name><surname>Thorleifsson</surname><given-names>G</given-names></name>, <etal>et al</etal> (<year>2010</year>) <article-title>Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus</article-title>. <source><italic>PLoS Genet</italic></source><volume>6</volume>: <fpage>e1001029</fpage><pub-id pub-id-type="pmid">20661439</pub-id></mixed-citation></ref><ref id="pone.0042380-Turnbull1"><label>3</label><mixed-citation publication-type="journal"><name><surname>Turnbull</surname><given-names>C</given-names></name>, <name><surname>Ahmed</surname><given-names>S</given-names></name>, <name><surname>Morrison</surname><given-names>J</given-names></name>, <name><surname>Pernet</surname><given-names>D</given-names></name>, <name><surname>Renwick</surname><given-names>A</given-names></name>, <etal>et al</etal> (<year>2010</year>) <article-title>Genome-wide association study identifies five new breast cancer susceptibility loci</article-title>. <source><italic>Nat Genet</italic></source><volume>42</volume>: <fpage>504</fpage>–<lpage>507</lpage><pub-id pub-id-type="pmid">20453838</pub-id></mixed-citation></ref><ref id="pone.0042380-Laird1"><label>4</label><mixed-citation publication-type="journal"><name><surname>Laird</surname><given-names>NM</given-names></name>, <name><surname>Mosteller</surname><given-names>F</given-names></name> (<year>1990</year>) <article-title>Some statistical methods for combining experimental results</article-title>. <source><italic>Int J Technol Assess Health Care</italic></source><volume>6</volume>: <fpage>5</fpage>–<lpage>30</lpage><pub-id pub-id-type="pmid">2361819</pub-id></mixed-citation></ref><ref id="pone.0042380-R1"><label>5</label><mixed-citation publication-type="book">R Development Core Team (2005) R: A language and environment for statistical computing. Vienna, Austria, R Foundation for Statistical Computing.</mixed-citation></ref><ref id="pone.0042380-Long1"><label>6</label><mixed-citation publication-type="journal"><name><surname>Long</surname><given-names>J</given-names></name>, <name><surname>Shu</surname><given-names>XO</given-names></name>, <name><surname>Cai</surname><given-names>Q</given-names></name>, <name><surname>Gao</surname><given-names>YT</given-names></name>, <name><surname>Zheng</surname><given-names>Y</given-names></name>, <etal>et al</etal> (<year>2010</year>) <article-title>Evaluation of breast cancer susceptibility Loci in chinese women</article-title>. <source><italic>Cancer Epidemiol Biomarkers Prev</italic></source><volume>19</volume>: <fpage>2357</fpage>–<lpage>2365</lpage><pub-id pub-id-type="pmid">20699374</pub-id></mixed-citation></ref><ref id="pone.0042380-Antoniou1"><label>7</label><mixed-citation publication-type="journal"><name><surname>Antoniou</surname><given-names>AC</given-names></name>, <name><surname>Kartsonaki</surname><given-names>C</given-names></name>, <name><surname>Sinilnikova</surname><given-names>OM</given-names></name>, <name><surname>Soucy</surname><given-names>P</given-names></name>, <name><surname>McGuffog</surname><given-names>L</given-names></name>, <etal>et al</etal> (<year>2011</year>) <article-title>Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers</article-title>. <source><italic>Hum Mol Genet</italic></source><volume>20(16)</volume>: <fpage>3304</fpage>–<lpage>3321</lpage><pub-id pub-id-type="pmid">21593217</pub-id></mixed-citation></ref><ref id="pone.0042380-Cai1"><label>8</label><mixed-citation publication-type="journal"><name><surname>Cai</surname><given-names>Q</given-names></name>, <name><surname>Wen</surname><given-names>W</given-names></name>, <name><surname>Qu</surname><given-names>S</given-names></name>, <name><surname>Li</surname><given-names>G</given-names></name>, <name><surname>Egan</surname><given-names>KM</given-names></name>, <etal>et al</etal> (<year>2011</year>) <article-title>Replication and Functional Genomic Analyses of the Breast Cancer Susceptibility Locus at 6q25.1 Generalize Its Importance in Women of Chinese, Japanese, and European Ancestry</article-title>. <source><italic>Cancer Res</italic></source><volume>71</volume>: <fpage>1344</fpage>–<lpage>1355</lpage><pub-id pub-id-type="pmid">21303983</pub-id></mixed-citation></ref><ref id="pone.0042380-The1"><label>9</label><mixed-citation publication-type="other">The Collaborative Oncological Gene-Environment Study (COGS) Project. Available: <ext-link ext-link-type="uri" xlink:href="http://www.cogseu.org">http://www.cogseu.org</ext-link> Accessed 2012 Jul 10.</mixed-citation></ref><ref id="pone.0042380-Ioannidis1"><label>10</label><mixed-citation publication-type="journal"><name><surname>Ioannidis</surname><given-names>JPA</given-names></name> (<year>2008</year>) <article-title>Why most discovered true associations are inflated</article-title>. <source>Epidemiology</source><volume>19(5)</volume>: <fpage>640</fpage>–<lpage>648</lpage><pub-id pub-id-type="pmid">18633328</pub-id></mixed-citation></ref><ref id="pone.0042380-Kraft1"><label>11</label><mixed-citation publication-type="journal"><name><surname>Kraft</surname><given-names>P</given-names></name> (<year>2008</year>) <article-title>Curses – winner’s and otherwise – in genetic epidemiology</article-title>. <source>Epidemiology</source><volume>19(5)</volume>: <fpage>649</fpage>–<lpage>651</lpage><pub-id pub-id-type="pmid">18703928</pub-id></mixed-citation></ref><ref id="pone.0042380-Li1"><label>12</label><mixed-citation publication-type="journal"><name><surname>Li</surname><given-names>WF</given-names></name>, <name><surname>Hou</surname><given-names>SX</given-names></name>, <name><surname>Yu</surname><given-names>B</given-names></name>, <name><surname>Li</surname><given-names>MM</given-names></name>, <name><surname>Ferec</surname><given-names>C</given-names></name>, <etal>et al</etal> (<year>2010</year>) <article-title>Genetics of osteoporosis: accelerating pace in gene identification and validation</article-title>. <source><italic>Hum Genet</italic></source><volume>127</volume>: <fpage>249</fpage>–<lpage>285</lpage><pub-id pub-id-type="pmid">20101412</pub-id></mixed-citation></ref><ref id="pone.0042380-Xie1"><label>13</label><mixed-citation publication-type="journal"><name><surname>Xie</surname><given-names>H</given-names></name>, <name><surname>Sun</surname><given-names>M</given-names></name>, <name><surname>Liao</surname><given-names>XB</given-names></name>, <name><surname>Yuan</surname><given-names>LQ</given-names></name>, <name><surname>Sheng</surname><given-names>ZF</given-names></name>, <etal>et al</etal> (<year>2010</year>) <article-title>Estrogen receptor-alpha36 mediates a bone-sparing effect of 17beta-estrodiol in postmenopausal women</article-title>. <source><italic>J Bone Miner Res</italic></source><volume>26</volume>: <fpage>156</fpage>–<lpage>168</lpage><pub-id pub-id-type="pmid">20578216</pub-id></mixed-citation></ref><ref id="pone.0042380-Dunbier1"><label>14</label><mixed-citation publication-type="journal"><name><surname>Dunbier</surname><given-names>AK</given-names></name>, <name><surname>Anderson</surname><given-names>H</given-names></name>, <name><surname>Ghazoui</surname><given-names>Z</given-names></name>, <name><surname>Lopez-Knowles</surname><given-names>E</given-names></name>, <name><surname>Pancholi</surname><given-names>S</given-names></name>, <etal>et al</etal> (<year>2011</year>) <article-title>ESR1 Is Co-Expressed with Closely Adjacent Uncharacterised Genes Spanning a Breast Cancer Susceptibility Locus at 6q25.1</article-title>. <source><italic>PLoS Genet</italic></source><volume>7</volume>: <fpage>e1001382</fpage><pub-id pub-id-type="pmid">21552322</pub-id></mixed-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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