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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Risk Factors for Severe Outcomes following 2009 Influenza A (H1N1) Infection: A Global Pooled Analysis</title><author><name sortKey="Van Kerkhove, Maria D" sort="Van Kerkhove, Maria D" uniqKey="Van Kerkhove M" first="Maria D." last="Van Kerkhove">Maria D. Van Kerkhove</name><affiliation><nlm:aff id="aff1"><addr-line>Global Influenza Programme, World Health Organization</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><addr-line>Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vandemaele, Katelijn A H" sort="Vandemaele, Katelijn A H" uniqKey="Vandemaele K" first="Katelijn A. H." last="Vandemaele">Katelijn A. H. Vandemaele</name><affiliation><nlm:aff id="aff1"><addr-line>Global Influenza Programme, World Health Organization</addr-line></nlm:aff></affiliation></author><author><name sortKey="Shinde, Vivek" sort="Shinde, Vivek" uniqKey="Shinde V" first="Vivek" last="Shinde">Vivek Shinde</name><affiliation><nlm:aff id="aff1"><addr-line>Global Influenza Programme, World Health Organization</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jaramillo Gutierrez, Giovanna" sort="Jaramillo Gutierrez, Giovanna" uniqKey="Jaramillo Gutierrez G" first="Giovanna" last="Jaramillo-Gutierrez">Giovanna Jaramillo-Gutierrez</name><affiliation><nlm:aff id="aff1"><addr-line>Global Influenza Programme, World Health Organization</addr-line></nlm:aff></affiliation></author><author><name sortKey="Koukounari, Artemis" sort="Koukounari, Artemis" uniqKey="Koukounari A" first="Artemis" last="Koukounari">Artemis Koukounari</name><affiliation><nlm:aff id="aff2"><addr-line>Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Donnelly, Christl A" sort="Donnelly, Christl A" uniqKey="Donnelly C" first="Christl A." last="Donnelly">Christl A. Donnelly</name><affiliation><nlm:aff id="aff2"><addr-line>Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Carlino, Luis O" sort="Carlino, Luis O" uniqKey="Carlino L" first="Luis O." last="Carlino">Luis O. Carlino</name><affiliation><nlm:aff id="aff3"><addr-line>Ministerio de Salud de la Nación, Buenos Aires, Argentina</addr-line></nlm:aff></affiliation></author><author><name sortKey="Owen, Rhonda" sort="Owen, Rhonda" uniqKey="Owen R" first="Rhonda" last="Owen">Rhonda Owen</name><affiliation><nlm:aff id="aff4"><addr-line>Influenza Surveillance Section, Surveillance Branch, Office of Health Protection, Department of Health and Ageing, Woden, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Paterson, Beverly" sort="Paterson, Beverly" uniqKey="Paterson B" first="Beverly" last="Paterson">Beverly Paterson</name><affiliation><nlm:aff id="aff4"><addr-line>Influenza Surveillance Section, Surveillance Branch, Office of Health Protection, Department of Health and Ageing, Woden, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pelletier, Louise" sort="Pelletier, Louise" uniqKey="Pelletier L" first="Louise" last="Pelletier">Louise Pelletier</name><affiliation><nlm:aff id="aff5"><addr-line>Influenza Surveillance Section, Public Health Agency of Canada, Ontario, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vachon, Julie" sort="Vachon, Julie" uniqKey="Vachon J" first="Julie" last="Vachon">Julie Vachon</name><affiliation><nlm:aff id="aff5"><addr-line>Influenza Surveillance Section, Public Health Agency of Canada, Ontario, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gonzalez, Claudia" sort="Gonzalez, Claudia" uniqKey="Gonzalez C" first="Claudia" last="Gonzalez">Claudia Gonzalez</name><affiliation><nlm:aff id="aff6"><addr-line>Departamento de Epidemiología, División de Planificación Sanitaria, Ministerio de Salud de Chile, Santiago, Chile</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hongjie, Yu" sort="Hongjie, Yu" uniqKey="Hongjie Y" first="Yu" last="Hongjie">Yu Hongjie</name><affiliation><nlm:aff id="aff7"><addr-line>Office for Disease Control and Emergency Response, Chinese Center for Disease Control and Prevention Beijing, China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zijian, Feng" sort="Zijian, Feng" uniqKey="Zijian F" first="Feng" last="Zijian">Feng Zijian</name><affiliation><nlm:aff id="aff7"><addr-line>Office for Disease Control and Emergency Response, Chinese Center for Disease Control and Prevention Beijing, China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chuang, Shuk Kwan" sort="Chuang, Shuk Kwan" uniqKey="Chuang S" first="Shuk Kwan" last="Chuang">Shuk Kwan Chuang</name><affiliation><nlm:aff id="aff8"><addr-line>Surveillance and Epidemiology Branch, Centre for Health Protection, Centre for Health Protection of Department of Health, Hong Kong</addr-line></nlm:aff></affiliation></author><author><name sortKey="Au, Albert" sort="Au, Albert" uniqKey="Au A" first="Albert" last="Au">Albert Au</name><affiliation><nlm:aff id="aff8"><addr-line>Surveillance and Epidemiology Branch, Centre for Health Protection, Centre for Health Protection of Department of Health, Hong Kong</addr-line></nlm:aff></affiliation></author><author><name sortKey="Buda, Silke" sort="Buda, Silke" uniqKey="Buda S" first="Silke" last="Buda">Silke Buda</name><affiliation><nlm:aff id="aff9"><addr-line>Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Krause, Gerard" sort="Krause, Gerard" uniqKey="Krause G" first="Gerard" last="Krause">Gerard Krause</name><affiliation><nlm:aff id="aff9"><addr-line>Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Haas, Walter" sort="Haas, Walter" uniqKey="Haas W" first="Walter" last="Haas">Walter Haas</name><affiliation><nlm:aff id="aff9"><addr-line>Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bonmarin, Isabelle" sort="Bonmarin, Isabelle" uniqKey="Bonmarin I" first="Isabelle" last="Bonmarin">Isabelle Bonmarin</name><affiliation><nlm:aff id="aff10"><addr-line>Département des Maladies Infectieuses, Institut de Veille, Sanitaire, Saint-Maurice Cedex, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Taniguichi, Kiyosu" sort="Taniguichi, Kiyosu" uniqKey="Taniguichi K" first="Kiyosu" last="Taniguichi">Kiyosu Taniguichi</name><affiliation><nlm:aff id="aff11"><addr-line>Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nakajima, Kensuke" sort="Nakajima, Kensuke" uniqKey="Nakajima K" first="Kensuke" last="Nakajima">Kensuke Nakajima</name><affiliation><nlm:aff id="aff12"><addr-line>Ministry of Health, Labour and Welfare, Tokyo, Japan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Shobayashi, Tokuaki" sort="Shobayashi, Tokuaki" uniqKey="Shobayashi T" first="Tokuaki" last="Shobayashi">Tokuaki Shobayashi</name><affiliation><nlm:aff id="aff12"><addr-line>Ministry of Health, Labour and Welfare, Tokyo, Japan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Takayama, Yoshihiro" sort="Takayama, Yoshihiro" uniqKey="Takayama Y" first="Yoshihiro" last="Takayama">Yoshihiro Takayama</name><affiliation><nlm:aff id="aff12"><addr-line>Ministry of Health, Labour and Welfare, Tokyo, Japan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sunagawa, Tomi" sort="Sunagawa, Tomi" uniqKey="Sunagawa T" first="Tomi" last="Sunagawa">Tomi Sunagawa</name><affiliation><nlm:aff id="aff11"><addr-line>Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Heraud, Jean Michel" sort="Heraud, Jean Michel" uniqKey="Heraud J" first="Jean Michel" last="Heraud">Jean Michel Heraud</name><affiliation><nlm:aff id="aff13"><addr-line>Virology Unit, Institut Pasteur from Madagascar, Antananarivo, Madagascar</addr-line></nlm:aff></affiliation></author><author><name sortKey="Orelle, Arnaud" sort="Orelle, Arnaud" uniqKey="Orelle A" first="Arnaud" last="Orelle">Arnaud Orelle</name><affiliation><nlm:aff id="aff13"><addr-line>Virology Unit, Institut Pasteur from Madagascar, Antananarivo, Madagascar</addr-line></nlm:aff></affiliation></author><author><name sortKey="Palacios, Ethel" sort="Palacios, Ethel" uniqKey="Palacios E" first="Ethel" last="Palacios">Ethel Palacios</name><affiliation><nlm:aff id="aff14"><addr-line>Directorate General of Epidemiology, Mexico City, Mexico</addr-line></nlm:aff></affiliation></author><author><name sortKey="Van Der Sande, Marianne A B" sort="Van Der Sande, Marianne A B" uniqKey="Van Der Sande M" first="Marianne A. B." last="Van Der Sande">Marianne A. B. Van Der Sande</name><affiliation><nlm:aff id="aff15"><addr-line>Epidemiology and Surveillance Unit, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wielders, C C H Lieke" sort="Wielders, C C H Lieke" uniqKey="Wielders C" first="C. C. H. Lieke" last="Wielders">C. C. H. Lieke Wielders</name><affiliation><nlm:aff id="aff15"><addr-line>Epidemiology and Surveillance Unit, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hunt, Darren" sort="Hunt, Darren" uniqKey="Hunt D" first="Darren" last="Hunt">Darren Hunt</name><affiliation><nlm:aff id="aff16"><addr-line>New Zealand Ministry of Health, Wellington, New Zealand</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cutter, Jeffrey" sort="Cutter, Jeffrey" uniqKey="Cutter J" first="Jeffrey" last="Cutter">Jeffrey Cutter</name><affiliation><nlm:aff id="aff17"><addr-line>Communicable Diseases Division at the Ministry of Health, Singapore</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lee, Vernon J" sort="Lee, Vernon J" uniqKey="Lee V" first="Vernon J." last="Lee">Vernon J. Lee</name><affiliation><nlm:aff id="aff18"><addr-line>Biodefence Centre, Ministry of Defence, Singapore</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff19"><addr-line>Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</addr-line></nlm:aff></affiliation></author><author><name sortKey="Thomas, Juno" sort="Thomas, Juno" uniqKey="Thomas J" first="Juno" last="Thomas">Juno Thomas</name><affiliation><nlm:aff id="aff20"><addr-line>Epidemiology and Surveillance Unit, Respiratory Virus Unit, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa</addr-line></nlm:aff></affiliation></author><author><name sortKey="Santa Olalla, Patricia" sort="Santa Olalla, Patricia" uniqKey="Santa Olalla P" first="Patricia" last="Santa-Olalla">Patricia Santa-Olalla</name><affiliation><nlm:aff id="aff21"><addr-line>Coordinating Centre for Health Alerts and Emergencies, Dirección General de Salud Pública y Sanidad Exterior Ministerio de Sanidad y Política Social, Madrid, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sierra Moros, Maria J" sort="Sierra Moros, Maria J" uniqKey="Sierra Moros M" first="Maria J." last="Sierra-Moros">Maria J. Sierra-Moros</name><affiliation><nlm:aff id="aff21"><addr-line>Coordinating Centre for Health Alerts and Emergencies, Dirección General de Salud Pública y Sanidad Exterior Ministerio de Sanidad y Política Social, Madrid, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hanshaoworakul, Wanna" sort="Hanshaoworakul, Wanna" uniqKey="Hanshaoworakul W" first="Wanna" last="Hanshaoworakul">Wanna Hanshaoworakul</name><affiliation><nlm:aff id="aff22"><addr-line>Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ungchusak, Kumnuan" sort="Ungchusak, Kumnuan" uniqKey="Ungchusak K" first="Kumnuan" last="Ungchusak">Kumnuan Ungchusak</name><affiliation><nlm:aff id="aff22"><addr-line>Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pebody, Richard" sort="Pebody, Richard" uniqKey="Pebody R" first="Richard" last="Pebody">Richard Pebody</name><affiliation><nlm:aff id="aff23"><addr-line>Health Protection Agency, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jain, Seema" sort="Jain, Seema" uniqKey="Jain S" first="Seema" last="Jain">Seema Jain</name><affiliation><nlm:aff id="aff24"><addr-line>Epidemiology and Prevention Branch, Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mounts, Anthony W" sort="Mounts, Anthony W" uniqKey="Mounts A" first="Anthony W." last="Mounts">Anthony W. Mounts</name><affiliation><nlm:aff id="aff1"><addr-line>Global Influenza Programme, World Health Organization</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21750667</idno><idno type="pmc">3130021</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130021</idno><idno type="RBID">PMC:3130021</idno><idno type="doi">10.1371/journal.pmed.1001053</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">002891</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002891</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Risk Factors for Severe Outcomes following 2009 Influenza A (H1N1) Infection: A Global Pooled Analysis</title><author><name sortKey="Van Kerkhove, Maria D" sort="Van Kerkhove, Maria D" uniqKey="Van Kerkhove M" first="Maria D." last="Van Kerkhove">Maria D. Van Kerkhove</name><affiliation><nlm:aff id="aff1"><addr-line>Global Influenza Programme, World Health Organization</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><addr-line>Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vandemaele, Katelijn A H" sort="Vandemaele, Katelijn A H" uniqKey="Vandemaele K" first="Katelijn A. H." last="Vandemaele">Katelijn A. H. Vandemaele</name><affiliation><nlm:aff id="aff1"><addr-line>Global Influenza Programme, World Health Organization</addr-line></nlm:aff></affiliation></author><author><name sortKey="Shinde, Vivek" sort="Shinde, Vivek" uniqKey="Shinde V" first="Vivek" last="Shinde">Vivek Shinde</name><affiliation><nlm:aff id="aff1"><addr-line>Global Influenza Programme, World Health Organization</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jaramillo Gutierrez, Giovanna" sort="Jaramillo Gutierrez, Giovanna" uniqKey="Jaramillo Gutierrez G" first="Giovanna" last="Jaramillo-Gutierrez">Giovanna Jaramillo-Gutierrez</name><affiliation><nlm:aff id="aff1"><addr-line>Global Influenza Programme, World Health Organization</addr-line></nlm:aff></affiliation></author><author><name sortKey="Koukounari, Artemis" sort="Koukounari, Artemis" uniqKey="Koukounari A" first="Artemis" last="Koukounari">Artemis Koukounari</name><affiliation><nlm:aff id="aff2"><addr-line>Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Donnelly, Christl A" sort="Donnelly, Christl A" uniqKey="Donnelly C" first="Christl A." last="Donnelly">Christl A. Donnelly</name><affiliation><nlm:aff id="aff2"><addr-line>Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Carlino, Luis O" sort="Carlino, Luis O" uniqKey="Carlino L" first="Luis O." last="Carlino">Luis O. Carlino</name><affiliation><nlm:aff id="aff3"><addr-line>Ministerio de Salud de la Nación, Buenos Aires, Argentina</addr-line></nlm:aff></affiliation></author><author><name sortKey="Owen, Rhonda" sort="Owen, Rhonda" uniqKey="Owen R" first="Rhonda" last="Owen">Rhonda Owen</name><affiliation><nlm:aff id="aff4"><addr-line>Influenza Surveillance Section, Surveillance Branch, Office of Health Protection, Department of Health and Ageing, Woden, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Paterson, Beverly" sort="Paterson, Beverly" uniqKey="Paterson B" first="Beverly" last="Paterson">Beverly Paterson</name><affiliation><nlm:aff id="aff4"><addr-line>Influenza Surveillance Section, Surveillance Branch, Office of Health Protection, Department of Health and Ageing, Woden, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pelletier, Louise" sort="Pelletier, Louise" uniqKey="Pelletier L" first="Louise" last="Pelletier">Louise Pelletier</name><affiliation><nlm:aff id="aff5"><addr-line>Influenza Surveillance Section, Public Health Agency of Canada, Ontario, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vachon, Julie" sort="Vachon, Julie" uniqKey="Vachon J" first="Julie" last="Vachon">Julie Vachon</name><affiliation><nlm:aff id="aff5"><addr-line>Influenza Surveillance Section, Public Health Agency of Canada, Ontario, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gonzalez, Claudia" sort="Gonzalez, Claudia" uniqKey="Gonzalez C" first="Claudia" last="Gonzalez">Claudia Gonzalez</name><affiliation><nlm:aff id="aff6"><addr-line>Departamento de Epidemiología, División de Planificación Sanitaria, Ministerio de Salud de Chile, Santiago, Chile</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hongjie, Yu" sort="Hongjie, Yu" uniqKey="Hongjie Y" first="Yu" last="Hongjie">Yu Hongjie</name><affiliation><nlm:aff id="aff7"><addr-line>Office for Disease Control and Emergency Response, Chinese Center for Disease Control and Prevention Beijing, China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zijian, Feng" sort="Zijian, Feng" uniqKey="Zijian F" first="Feng" last="Zijian">Feng Zijian</name><affiliation><nlm:aff id="aff7"><addr-line>Office for Disease Control and Emergency Response, Chinese Center for Disease Control and Prevention Beijing, China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chuang, Shuk Kwan" sort="Chuang, Shuk Kwan" uniqKey="Chuang S" first="Shuk Kwan" last="Chuang">Shuk Kwan Chuang</name><affiliation><nlm:aff id="aff8"><addr-line>Surveillance and Epidemiology Branch, Centre for Health Protection, Centre for Health Protection of Department of Health, Hong Kong</addr-line></nlm:aff></affiliation></author><author><name sortKey="Au, Albert" sort="Au, Albert" uniqKey="Au A" first="Albert" last="Au">Albert Au</name><affiliation><nlm:aff id="aff8"><addr-line>Surveillance and Epidemiology Branch, Centre for Health Protection, Centre for Health Protection of Department of Health, Hong Kong</addr-line></nlm:aff></affiliation></author><author><name sortKey="Buda, Silke" sort="Buda, Silke" uniqKey="Buda S" first="Silke" last="Buda">Silke Buda</name><affiliation><nlm:aff id="aff9"><addr-line>Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Krause, Gerard" sort="Krause, Gerard" uniqKey="Krause G" first="Gerard" last="Krause">Gerard Krause</name><affiliation><nlm:aff id="aff9"><addr-line>Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Haas, Walter" sort="Haas, Walter" uniqKey="Haas W" first="Walter" last="Haas">Walter Haas</name><affiliation><nlm:aff id="aff9"><addr-line>Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bonmarin, Isabelle" sort="Bonmarin, Isabelle" uniqKey="Bonmarin I" first="Isabelle" last="Bonmarin">Isabelle Bonmarin</name><affiliation><nlm:aff id="aff10"><addr-line>Département des Maladies Infectieuses, Institut de Veille, Sanitaire, Saint-Maurice Cedex, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Taniguichi, Kiyosu" sort="Taniguichi, Kiyosu" uniqKey="Taniguichi K" first="Kiyosu" last="Taniguichi">Kiyosu Taniguichi</name><affiliation><nlm:aff id="aff11"><addr-line>Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nakajima, Kensuke" sort="Nakajima, Kensuke" uniqKey="Nakajima K" first="Kensuke" last="Nakajima">Kensuke Nakajima</name><affiliation><nlm:aff id="aff12"><addr-line>Ministry of Health, Labour and Welfare, Tokyo, Japan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Shobayashi, Tokuaki" sort="Shobayashi, Tokuaki" uniqKey="Shobayashi T" first="Tokuaki" last="Shobayashi">Tokuaki Shobayashi</name><affiliation><nlm:aff id="aff12"><addr-line>Ministry of Health, Labour and Welfare, Tokyo, Japan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Takayama, Yoshihiro" sort="Takayama, Yoshihiro" uniqKey="Takayama Y" first="Yoshihiro" last="Takayama">Yoshihiro Takayama</name><affiliation><nlm:aff id="aff12"><addr-line>Ministry of Health, Labour and Welfare, Tokyo, Japan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sunagawa, Tomi" sort="Sunagawa, Tomi" uniqKey="Sunagawa T" first="Tomi" last="Sunagawa">Tomi Sunagawa</name><affiliation><nlm:aff id="aff11"><addr-line>Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Heraud, Jean Michel" sort="Heraud, Jean Michel" uniqKey="Heraud J" first="Jean Michel" last="Heraud">Jean Michel Heraud</name><affiliation><nlm:aff id="aff13"><addr-line>Virology Unit, Institut Pasteur from Madagascar, Antananarivo, Madagascar</addr-line></nlm:aff></affiliation></author><author><name sortKey="Orelle, Arnaud" sort="Orelle, Arnaud" uniqKey="Orelle A" first="Arnaud" last="Orelle">Arnaud Orelle</name><affiliation><nlm:aff id="aff13"><addr-line>Virology Unit, Institut Pasteur from Madagascar, Antananarivo, Madagascar</addr-line></nlm:aff></affiliation></author><author><name sortKey="Palacios, Ethel" sort="Palacios, Ethel" uniqKey="Palacios E" first="Ethel" last="Palacios">Ethel Palacios</name><affiliation><nlm:aff id="aff14"><addr-line>Directorate General of Epidemiology, Mexico City, Mexico</addr-line></nlm:aff></affiliation></author><author><name sortKey="Van Der Sande, Marianne A B" sort="Van Der Sande, Marianne A B" uniqKey="Van Der Sande M" first="Marianne A. B." last="Van Der Sande">Marianne A. B. Van Der Sande</name><affiliation><nlm:aff id="aff15"><addr-line>Epidemiology and Surveillance Unit, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wielders, C C H Lieke" sort="Wielders, C C H Lieke" uniqKey="Wielders C" first="C. C. H. Lieke" last="Wielders">C. C. H. Lieke Wielders</name><affiliation><nlm:aff id="aff15"><addr-line>Epidemiology and Surveillance Unit, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hunt, Darren" sort="Hunt, Darren" uniqKey="Hunt D" first="Darren" last="Hunt">Darren Hunt</name><affiliation><nlm:aff id="aff16"><addr-line>New Zealand Ministry of Health, Wellington, New Zealand</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cutter, Jeffrey" sort="Cutter, Jeffrey" uniqKey="Cutter J" first="Jeffrey" last="Cutter">Jeffrey Cutter</name><affiliation><nlm:aff id="aff17"><addr-line>Communicable Diseases Division at the Ministry of Health, Singapore</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lee, Vernon J" sort="Lee, Vernon J" uniqKey="Lee V" first="Vernon J." last="Lee">Vernon J. Lee</name><affiliation><nlm:aff id="aff18"><addr-line>Biodefence Centre, Ministry of Defence, Singapore</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff19"><addr-line>Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</addr-line></nlm:aff></affiliation></author><author><name sortKey="Thomas, Juno" sort="Thomas, Juno" uniqKey="Thomas J" first="Juno" last="Thomas">Juno Thomas</name><affiliation><nlm:aff id="aff20"><addr-line>Epidemiology and Surveillance Unit, Respiratory Virus Unit, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa</addr-line></nlm:aff></affiliation></author><author><name sortKey="Santa Olalla, Patricia" sort="Santa Olalla, Patricia" uniqKey="Santa Olalla P" first="Patricia" last="Santa-Olalla">Patricia Santa-Olalla</name><affiliation><nlm:aff id="aff21"><addr-line>Coordinating Centre for Health Alerts and Emergencies, Dirección General de Salud Pública y Sanidad Exterior Ministerio de Sanidad y Política Social, Madrid, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sierra Moros, Maria J" sort="Sierra Moros, Maria J" uniqKey="Sierra Moros M" first="Maria J." last="Sierra-Moros">Maria J. Sierra-Moros</name><affiliation><nlm:aff id="aff21"><addr-line>Coordinating Centre for Health Alerts and Emergencies, Dirección General de Salud Pública y Sanidad Exterior Ministerio de Sanidad y Política Social, Madrid, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hanshaoworakul, Wanna" sort="Hanshaoworakul, Wanna" uniqKey="Hanshaoworakul W" first="Wanna" last="Hanshaoworakul">Wanna Hanshaoworakul</name><affiliation><nlm:aff id="aff22"><addr-line>Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ungchusak, Kumnuan" sort="Ungchusak, Kumnuan" uniqKey="Ungchusak K" first="Kumnuan" last="Ungchusak">Kumnuan Ungchusak</name><affiliation><nlm:aff id="aff22"><addr-line>Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pebody, Richard" sort="Pebody, Richard" uniqKey="Pebody R" first="Richard" last="Pebody">Richard Pebody</name><affiliation><nlm:aff id="aff23"><addr-line>Health Protection Agency, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jain, Seema" sort="Jain, Seema" uniqKey="Jain S" first="Seema" last="Jain">Seema Jain</name><affiliation><nlm:aff id="aff24"><addr-line>Epidemiology and Prevention Branch, Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mounts, Anthony W" sort="Mounts, Anthony W" uniqKey="Mounts A" first="Anthony W." last="Mounts">Anthony W. Mounts</name><affiliation><nlm:aff id="aff1"><addr-line>Global Influenza Programme, World Health Organization</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS Medicine</title><idno type="ISSN">1549-1277</idno><idno type="eISSN">1549-1676</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>This study analyzes data from 19 countries (from April 2009 to Jan 2010), comprising some 70,000 hospitalized patients with severe H1N1 infection, to reveal risk factors for severe pandemic influenza, which include chronic illness, cardiac disease, chronic respiratory disease, and diabetes.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Chan, M" uniqKey="Chan M">M 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS Med</journal-id><journal-id journal-id-type="iso-abbrev">PLoS Med</journal-id><journal-id journal-id-type="publisher-id">PLoS</journal-id><journal-id journal-id-type="pmc">plosmed</journal-id><journal-title-group><journal-title>PLoS Medicine</journal-title></journal-title-group><issn pub-type="ppub">1549-1277</issn><issn pub-type="epub">1549-1676</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21750667</article-id><article-id pub-id-type="pmc">3130021</article-id><article-id pub-id-type="publisher-id">PMEDICINE-D-10-00373</article-id><article-id pub-id-type="doi">10.1371/journal.pmed.1001053</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine</subject><subj-group><subject>Global Health</subject></subj-group><subj-group><subject>Infectious Diseases</subject><subj-group><subject>Viral Diseases</subject><subj-group><subject>Influenza</subject></subj-group></subj-group></subj-group><subj-group><subject>Public Health</subject></subj-group></subj-group></article-categories><title-group><article-title>Risk Factors for Severe Outcomes following 2009 Influenza A (H1N1) Infection: A Global Pooled Analysis</article-title><alt-title alt-title-type="running-head">Risk Factors for H1N1pdm Severity</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Van Kerkhove</surname><given-names>Maria D.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vandemaele</surname><given-names>Katelijn A. H.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shinde</surname><given-names>Vivek</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jaramillo-Gutierrez</surname><given-names>Giovanna</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Koukounari</surname><given-names>Artemis</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Donnelly</surname><given-names>Christl A.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Carlino</surname><given-names>Luis O.</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Owen</surname><given-names>Rhonda</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Paterson</surname><given-names>Beverly</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pelletier</surname><given-names>Louise</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vachon</surname><given-names>Julie</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gonzalez</surname><given-names>Claudia</given-names></name><xref ref-type="aff" rid="aff6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hongjie</surname><given-names>Yu</given-names></name><xref ref-type="aff" rid="aff7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zijian</surname><given-names>Feng</given-names></name><xref ref-type="aff" rid="aff7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chuang</surname><given-names>Shuk Kwan</given-names></name><xref ref-type="aff" rid="aff8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Au</surname><given-names>Albert</given-names></name><xref ref-type="aff" rid="aff8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Buda</surname><given-names>Silke</given-names></name><xref ref-type="aff" rid="aff9"><sup>9</sup></xref></contrib><contrib contrib-type="author"><name><surname>Krause</surname><given-names>Gerard</given-names></name><xref ref-type="aff" rid="aff9"><sup>9</sup></xref></contrib><contrib contrib-type="author"><name><surname>Haas</surname><given-names>Walter</given-names></name><xref ref-type="aff" rid="aff9"><sup>9</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bonmarin</surname><given-names>Isabelle</given-names></name><xref ref-type="aff" rid="aff10"><sup>10</sup></xref></contrib><contrib contrib-type="author"><name><surname>Taniguichi</surname><given-names>Kiyosu</given-names></name><xref ref-type="aff" rid="aff11"><sup>11</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nakajima</surname><given-names>Kensuke</given-names></name><xref ref-type="aff" rid="aff12"><sup>12</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shobayashi</surname><given-names>Tokuaki</given-names></name><xref ref-type="aff" rid="aff12"><sup>12</sup></xref></contrib><contrib contrib-type="author"><name><surname>Takayama</surname><given-names>Yoshihiro</given-names></name><xref ref-type="aff" rid="aff12"><sup>12</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sunagawa</surname><given-names>Tomi</given-names></name><xref ref-type="aff" rid="aff11"><sup>11</sup></xref></contrib><contrib contrib-type="author"><name><surname>Heraud</surname><given-names>Jean Michel</given-names></name><xref ref-type="aff" rid="aff13"><sup>13</sup></xref></contrib><contrib contrib-type="author"><name><surname>Orelle</surname><given-names>Arnaud</given-names></name><xref ref-type="aff" rid="aff13"><sup>13</sup></xref></contrib><contrib contrib-type="author"><name><surname>Palacios</surname><given-names>Ethel</given-names></name><xref ref-type="aff" rid="aff14"><sup>14</sup></xref></contrib><contrib contrib-type="author"><name><surname>van der Sande</surname><given-names>Marianne A. B.</given-names></name><xref ref-type="aff" rid="aff15"><sup>15</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wielders</surname><given-names>C. C. H. Lieke</given-names></name><xref ref-type="aff" rid="aff15"><sup>15</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hunt</surname><given-names>Darren</given-names></name><xref ref-type="aff" rid="aff16"><sup>16</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cutter</surname><given-names>Jeffrey</given-names></name><xref ref-type="aff" rid="aff17"><sup>17</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Vernon J.</given-names></name><xref ref-type="aff" rid="aff18"><sup>18</sup></xref><xref ref-type="aff" rid="aff19"><sup>19</sup></xref></contrib><contrib contrib-type="author"><name><surname>Thomas</surname><given-names>Juno</given-names></name><xref ref-type="aff" rid="aff20"><sup>20</sup></xref></contrib><contrib contrib-type="author"><name><surname>Santa-Olalla</surname><given-names>Patricia</given-names></name><xref ref-type="aff" rid="aff21"><sup>21</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sierra-Moros</surname><given-names>Maria J.</given-names></name><xref ref-type="aff" rid="aff21"><sup>21</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hanshaoworakul</surname><given-names>Wanna</given-names></name><xref ref-type="aff" rid="aff22"><sup>22</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ungchusak</surname><given-names>Kumnuan</given-names></name><xref ref-type="aff" rid="aff22"><sup>22</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pebody</surname><given-names>Richard</given-names></name><xref ref-type="aff" rid="aff23"><sup>23</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jain</surname><given-names>Seema</given-names></name><xref ref-type="aff" rid="aff24"><sup>24</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mounts</surname><given-names>Anthony W.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><collab>on behalf of the WHO Working Group for Risk Factors for Severe H1N1pdm Infection</collab></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Global Influenza Programme, World Health Organization</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom</addr-line></aff><aff id="aff3"><label>3</label><addr-line>Ministerio de Salud de la Nación, Buenos Aires, Argentina</addr-line></aff><aff id="aff4"><label>4</label><addr-line>Influenza Surveillance Section, Surveillance Branch, Office of Health Protection, Department of Health and Ageing, Woden, Australia</addr-line></aff><aff id="aff5"><label>5</label><addr-line>Influenza Surveillance Section, Public Health Agency of Canada, Ontario, Canada</addr-line></aff><aff id="aff6"><label>6</label><addr-line>Departamento de Epidemiología, División de Planificación Sanitaria, Ministerio de Salud de Chile, Santiago, Chile</addr-line></aff><aff id="aff7"><label>7</label><addr-line>Office for Disease Control and Emergency Response, Chinese Center for Disease Control and Prevention Beijing, China</addr-line></aff><aff id="aff8"><label>8</label><addr-line>Surveillance and Epidemiology Branch, Centre for Health Protection, Centre for Health Protection of Department of Health, Hong Kong</addr-line></aff><aff id="aff9"><label>9</label><addr-line>Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany</addr-line></aff><aff id="aff10"><label>10</label><addr-line>Département des Maladies Infectieuses, Institut de Veille, Sanitaire, Saint-Maurice Cedex, France</addr-line></aff><aff id="aff11"><label>11</label><addr-line>Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan</addr-line></aff><aff id="aff12"><label>12</label><addr-line>Ministry of Health, Labour and Welfare, Tokyo, Japan</addr-line></aff><aff id="aff13"><label>13</label><addr-line>Virology Unit, Institut Pasteur from Madagascar, Antananarivo, Madagascar</addr-line></aff><aff id="aff14"><label>14</label><addr-line>Directorate General of Epidemiology, Mexico City, Mexico</addr-line></aff><aff id="aff15"><label>15</label><addr-line>Epidemiology and Surveillance Unit, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands</addr-line></aff><aff id="aff16"><label>16</label><addr-line>New Zealand Ministry of Health, Wellington, New Zealand</addr-line></aff><aff id="aff17"><label>17</label><addr-line>Communicable Diseases Division at the Ministry of Health, Singapore</addr-line></aff><aff id="aff18"><label>18</label><addr-line>Biodefence Centre, Ministry of Defence, Singapore</addr-line></aff><aff id="aff19"><label>19</label><addr-line>Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</addr-line></aff><aff id="aff20"><label>20</label><addr-line>Epidemiology and Surveillance Unit, Respiratory Virus Unit, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa</addr-line></aff><aff id="aff21"><label>21</label><addr-line>Coordinating Centre for Health Alerts and Emergencies, Dirección General de Salud Pública y Sanidad Exterior Ministerio de Sanidad y Política Social, Madrid, Spain</addr-line></aff><aff id="aff22"><label>22</label><addr-line>Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand</addr-line></aff><aff id="aff23"><label>23</label><addr-line>Health Protection Agency, London, United Kingdom</addr-line></aff><aff id="aff24"><label>24</label><addr-line>Epidemiology and Prevention Branch, Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Peiris</surname><given-names>J. S. Malik</given-names></name><role>Academic Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1">The University of Hong Kong, Hong Kong</aff><author-notes><corresp id="cor1">* E-mail: <email>mountsa@who.int</email></corresp><fn fn-type="con"><p>Conceived and designed the experiments: AWM MDVK KAHV VS GJG. Analyzed the data: MDVK KAHV VS GJG AWM CAD AK. Wrote the paper: MDVK KAHV VS GJG AWM. <ext-link ext-link-type="uri" xlink:href="http://www.icmje.org/">ICMJE</ext-link> criteria for authorship read and met: MDVK KAHV VS GJG LOC RO LP JV CG YH FZ SKC AA SB GK WH IB KT KN TS YT TS JMH AO EP MABV LW DH JC VJL JT PSO MJS WH JKU RP SJ AWM CAD AK. Agree with the manuscript's results and conclusions: MDVK KAHV VS GJG LOC RO LP JV CG YH FZ SKC AA SB GK WH IB KT KN TS YT TS JMH AO EP MABV LW DH JC VJL JT PSO MJS WH JKU RP SJ AWM CAD AK. Wrote the first draft of the paper: MDVK KAHV VS GJG AWM. Reviewed and edited several versions of the manuscript: LOC RO LP JV CG YH FZ SKC AA SB GK WH IB KT KN TS YT TS JMH AO EP MABV LW DH JC VJL JT PSO MJS WH JKU RP SJ.</p></fn></author-notes><pub-date pub-type="collection"><month>7</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>5</day><month>7</month><year>2011</year></pub-date><volume>8</volume><issue>7</issue><elocation-id>e1001053</elocation-id><history><date date-type="received"><day>27</day><month>10</month><year>2010</year></date><date date-type="accepted"><day>18</day><month>5</month><year>2011</year></date></history><permissions><copyright-statement>This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.</copyright-statement><copyright-year>2011</copyright-year><license xlink:href="https://creativecommons.org/publicdomain/zero/1.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.</license-p></license></permissions><abstract abstract-type="toc"><p>This study analyzes data from 19 countries (from April 2009 to Jan 2010), comprising some 70,000 hospitalized patients with severe H1N1 infection, to reveal risk factors for severe pandemic influenza, which include chronic illness, cardiac disease, chronic respiratory disease, and diabetes.</p></abstract><abstract><sec><title>Background</title><p>Since the start of the 2009 influenza A pandemic (H1N1pdm), the World Health Organization and its member states have gathered information to characterize the clinical severity of H1N1pdm infection and to assist policy makers to determine risk groups for targeted control measures.</p></sec><sec><title>Methods and Findings</title><p>Data were collected on approximately 70,000 laboratory-confirmed hospitalized H1N1pdm patients, 9,700 patients admitted to intensive care units (ICUs), and 2,500 deaths reported between 1 April 2009 and 1 January 2010 from 19 countries or administrative regions—Argentina, Australia, Canada, Chile, China, France, Germany, Hong Kong SAR, Japan, Madagascar, Mexico, the Netherlands, New Zealand, Singapore, South Africa, Spain, Thailand, the United States, and the United Kingdom—to characterize and compare the distribution of risk factors among H1N1pdm patients at three levels of severity: hospitalizations, ICU admissions, and deaths. The median age of patients increased with severity of disease. The highest per capita risk of hospitalization was among patients <5 y and 5–14 y (relative risk [RR] = 3.3 and 3.2, respectively, compared to the general population), whereas the highest risk of death per capita was in the age groups 50–64 y and ≥65 y (RR = 1.5 and 1.6, respectively, compared to the general population). Similarly, the ratio of H1N1pdm deaths to hospitalizations increased with age and was the highest in the ≥65-y-old age group, indicating that while infection rates have been observed to be very low in the oldest age group, risk of death in those over the age of 64 y who became infected was higher than in younger groups. The proportion of H1N1pdm patients with one or more reported chronic conditions increased with severity (median = 31.1%, 52.3%, and 61.8% of hospitalized, ICU-admitted, and fatal H1N1pdm cases, respectively). With the exception of the risk factors asthma, pregnancy, and obesity, the proportion of patients with each risk factor increased with severity level. For all levels of severity, pregnant women in their third trimester consistently accounted for the majority of the total of pregnant women. Our findings suggest that morbid obesity might be a risk factor for ICU admission and fatal outcome (RR = 36.3).</p></sec><sec><title>Conclusions</title><p>Our results demonstrate that risk factors for severe H1N1pdm infection are similar to those for seasonal influenza, with some notable differences, such as younger age groups and obesity, and reinforce the need to identify and protect groups at highest risk of severe outcomes.</p></sec><sec><title></title><p><italic>Please see later in the article for the Editors' Summary</italic></p></sec></abstract><abstract abstract-type="editor"><title>Editors' Summary</title><sec id="s7a1"><title>Background</title><p>In April 2009, a new strain of influenza A H1N1 was first identified in Mexico and the United States and subsequently spread around the world. In June 2009, the World Health Organization (WHO) declared a pandemic alert phase 6, which continued until August 2010. Throughout the pandemic, WHO and member states gathered information to characterize the patterns of risk associated with the new influenza A H1N1 virus infection and to assess the clinical picture. Although risk factors for severe disease following seasonal influenza infection have been well documented in many countries (for example, pregnancy; chronic medical conditions such as pulmonary, cardiovascular, renal, hepatic, neuromuscular, hematologic, and metabolic disorders; some cognitive conditions; and immunodeficiency), risk factors for severe disease following infection early in the 2009 H1N1 pandemic were largely unknown.</p></sec><sec id="s7a2"><title>Why Was This Study Done?</title><p>Many countries have recently reported data on the association between severe H1N1 influenza and a variety of underlying risk factors, but because these data are presented in different formats, making direct comparisons across countries is difficult, with no clear consensus for some conditions. Therefore, to assess the frequency and distribution of known and new potential risk factors for severe H1N1 infection, this study was conducted to collect data (from 1 April 2009 to 1 January 2010) from surveillance programs of the Ministries of Health or National Public Health Institutes in 19 countries―Argentina, Australia, Canada, Chile, China, France, Germany, Hong Kong (special administrative region), Japan, Madagascar, Mexico, the Netherlands, New Zealand, Singapore, South Africa, Spain, Thailand, the United States, and the United Kingdom.</p></sec><sec id="s7a3"><title>What Did the Researchers Do and Find?</title><p>As part of routine surveillance, countries were asked to provide risk factor data on laboratory-confirmed H1N1 in patients who were admitted to hospital, admitted to the intensive care unit (ICU), or had died because of their infection, using a standardized format. The researchers grouped potential risk conditions into four categories: age, chronic medical illnesses, pregnancy (by trimester), and other conditions that were not previously considered as risk conditions for severe influenza outcomes, such as obesity. For each risk factor (except pregnancy), the researchers calculated the percentage of each group of patients using the total number of cases reported in each severity category (hospitalization, admission to ICU, and death). To evaluate the risk associated with pregnancy, the researchers used the ratio of pregnant women to all women of childbearing age (age 15–49 years) at each level of severity to describe the differences between levels.</p><p>The researchers were able to collect data on approximately 70,000 patients requiring hospitalization, 9,700 patients admitted to the ICU, and 2,500 patients who died from H1N1 infection. The proportion of patients with H1N1 with one or more reported chronic conditions increased with severity—the median was 31.1% of hospitalized patients, 52.3% of patients admitted to the ICU, and 61.8% of patients who died. For all levels of severity, pregnant women in their third trimester consistently accounted for the majority of the total of pregnant women. The proportion of patients with obesity increased with increasing disease severity—median of 6% of hospitalized patients, 11.3% of patients admitted to the ICU, and 12.0% of all deaths from H1N1.</p></sec><sec id="s7a4"><title>What Do These Findings Mean?</title><p>These findings show that risk factors for severe H1N1 infection are similar to those for seasonal influenza, with some notable differences: a substantial proportion of people with severe and fatal cases of H1N1 had pre-existing chronic illness, which indicates that the presence of chronic illness increases the likelihood of death. Cardiac disease, chronic respiratory disease, and diabetes are important risk factors for severe disease that will be especially relevant for countries with high rates of these illnesses. Approximately 2/3 of hospitalized people and 40% of people who died from H1N1 infection did not have any identified pre-existing chronic illness, but this study was not able to comprehensively assess how many of these cases had other risk factors, such as pregnancy, obesity, smoking, and alcohol misuse. Because of large differences between countries, the role of risk factors such as obesity and pregnancy need further study—although there is sufficient evidence to support vaccination and early intervention for pregnant women. Overall, the findings of this study reinforce the need to identify and target high-risk groups for interventions such as immunization, early medical advice, and use of antiviral medications.</p></sec><sec id="s7a5"><title>Additional Information</title><p>Please access these Web sites via the online version of this summary at <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1371/journal.pmed.1001053">http://dx.doi.org/10.1371/journal.pmed.1001053</ext-link>.</p><list list-type="bullet"><list-item><p>WHO provides a <ext-link ext-link-type="uri" xlink:href="http://www.who.int/csr/disease/influenza/en/index.html">Global Alert and Response (GAR)</ext-link> with updates on a number of influenza-related topics</p></list-item><list-item><p>The US Centers for Disease Control and Prevention provides information on <ext-link ext-link-type="uri" xlink:href="http://www.cdc.gov/h1n1flu/">risk factors and H1N1</ext-link></p></list-item></list></sec></abstract><counts><page-count count="12"></page-count></counts></article-meta></front><body><sec id="s1"><title>Introduction</title><p>In late April 2009, a novel strain of influenza A H1N1 was identified in Mexico and the United States. This virus quickly spread globally, and on June 11, 2009, the World Health Organization (WHO) declared a pandemic alert phase 6, indicating that the first influenza pandemic of the 21<sup>st</sup> century had begun <xref rid="pmed.1001053-Centers1" ref-type="bibr">[1]</xref>–<xref rid="pmed.1001053-Chan1" ref-type="bibr">[3]</xref>. Many Northern hemisphere temperate countries experienced their first wave of infection during the spring and summer months of 2009, followed by an early 2009 fall influenza season. Southern hemisphere temperate countries experienced the first wave of infection during their winter of 2009, and at the time of writing are finishing their winter 2010 season. By the end of 2009, the peak of the local influenza epidemic had passed in most countries around the world <xref rid="pmed.1001053-World2" ref-type="bibr">[4]</xref>.</p><p>Since the start of the pandemic, WHO and member states have been gathering information to characterize the clinical picture and patterns of risk associated with the 2009 pandemic influenza A H1N1 (H1N1pdm) virus infection to assist public health policy makers in targeting of vaccination strategies, antiviral use, and other control measures. Risk factors for severe disease following seasonal influenza infection have been well documented in many countries, and include chronic medical conditions such as pulmonary, cardiovascular, renal, hepatic, neuromuscular, hematologic, and metabolic disorders, some cognitive conditions, and immunodeficiency <xref rid="pmed.1001053-National1" ref-type="bibr">[5]</xref>–<xref rid="pmed.1001053-Mereckiene1" ref-type="bibr">[7]</xref>. The risk associated with seasonal influenza during pregnancy is less well documented but in previous pandemics, pregnant women were identified as being at increased risk of adverse outcomes, and many countries include healthy pregnant women among the seasonal influenza high risk groups as well <xref rid="pmed.1001053-Dodd1" ref-type="bibr">[8]</xref>–<xref rid="pmed.1001053-Neuzil1" ref-type="bibr">[11]</xref>. However, early in the 2009 H1N1 pandemic, risk factors for severe disease following infection were largely unknown. Following a series of teleconferences organized by WHO with clinicians treating H1N1pdm patients around the world, it appeared that the most common risk factors for severe H1N1pdm disease were similar to those for seasonal influenza infection; however, several new factors (e.g., obesity and tuberculosis [TB]) were also observed with high frequency in some countries. It was also noted that members of indigenous/aboriginal communities in some countries appeared to be overrepresented among severe cases <xref rid="pmed.1001053-World3" ref-type="bibr">[12]</xref>.</p><p>While many countries have recently reported data on the association between severe H1N1pdm influenza and the presence of a variety of underlying risk factors (e.g., <xref rid="pmed.1001053-The1" ref-type="bibr">[13]</xref>–<xref rid="pmed.1001053-Yang1" ref-type="bibr">[26]</xref>), these data are presented in different formats, making direct comparisons across countries difficult, and no clear consensus has emerged for some conditions. This paper presents data from approximately 70,000 lab-confirmed hospitalized and 2,500 fatal cases of H1N1pdm infection in 19 countries or administrative regions—Argentina, Australia, Canada, Chile, China, France, Germany, Hong Kong SAR, Japan, Madagascar, Mexico, the Netherlands, New Zealand, Singapore, South Africa, Spain, Thailand, the United States, and the United Kingdom—in order to characterize and compare the distribution of underlying risk factors among H1N1pdm confirmed patients who were hospitalized, admitted to an intensive care unit (ICU), or died, and to assess the frequency and distribution of known and new potential risk factors for severe H1N1pdm infection.</p></sec><sec sec-type="methods" id="s2"><title>Methods</title><p>This study compares data primarily obtained from surveillance programs of the Ministries of Health or National Public Health Institutes of 19 countries or administrative regions covering the period 1 April 2009 to 1 January 2010. Countries were asked to provide risk factor data on laboratory-confirmed cases using a standardized format for this analysis. The data were collected in the course of routine surveillance, methods of which varied from country to country <xref rid="pmed.1001053-Shimada1" ref-type="bibr">[27]</xref>–<xref rid="pmed.1001053-Kong1" ref-type="bibr">[49]</xref>, and were reported anonymously and as aggregate data; hence, no ethics approval was required. It should be noted that considerable effort was put into negotiating permission for these data to be presented in these formats. As many countries would not be willing to have their country-specific data published in direct comparisons with others, we are taking the approach of publishing data from a wide range of countries and showing the variability observed, so that results from specific studies can be compared with the international results reported here.</p><p>Potential risk factors were grouped into four categories: age, chronic medical illnesses, pregnancy (by trimester), and “other,” which included conditions that were not previously considered as risk factors for severe influenza outcomes, such as obesity, membership in a vulnerable social or ethnic group, and TB. Details of the standardized format and definitions of each of the conditions are provided in <xref ref-type="supplementary-material" rid="pmed.1001053.s001">Text S1</xref>.</p><p>Risk factor information was collected separately for three levels of severity of illness in laboratory-confirmed patients: hospitalizations, admissions to ICU, and fatalities by country. Details of the available data from countries by risk factor and severity level are provided in . For each risk factor, except for pregnancy, the percentage of patients who were hospitalized, were admitted to ICU, and died was calculated using the total number of cases reported in each severity category. To evaluate the risk associated with pregnancy, the ratio of pregnant women to all women of childbearing age (age 15–49 y) in each level of severity was used to describe the differences between levels. The overall median and interquartile ranges (IQRs) were calculated for each risk factor using all available data. In addition, where available, countries provided baseline comparison data for prevalence of the risk factor in the general population (details and sources provided in <xref ref-type="supplementary-material" rid="pmed.1001053.s001">Text S1</xref>). Data on age were provided by age groups (<5, 5–14, 15–24, 25–49, 50–64, and ≥65 y).</p><sec id="s2a"><title>Risk of Severe Disease</title><p>Where data were available, we calculated the risk for severe H1N1pdm outcomes (hospitalization, admission to ICU, and death) compared to the prevalence of risk factors in the general population (relative risk [RR] of hospitalization [RR<sub>hosp</sub>], RR of ICU admission [RR<sub>ICU</sub>], and RR of death [RR<sub>death</sub>]) by country. See <xref ref-type="supplementary-material" rid="pmed.1001053.s001">Text S1</xref> for more information and formulae.</p><p>For pregnancy, we first calculated the proportion of women of childbearing age who were pregnant in each severity category by dividing the number of pregnant women in that category by the number of women of childbearing age in that category. As individual case data were not available, we calculated the number of fertile women in each level of severity using the numbers of patients in each level of severity in the age range between 15 and 49 y multiplied by the percentage for that severity level that was female. Unless provided by the country, the point prevalence of pregnant women in the general population (the denominator of the RR calculation) was calculated using crude birth rate and 2010 United Nations population estimates <xref rid="pmed.1001053-United1" ref-type="bibr">[50]</xref> to derive the annual number of pregnancies, multiplied by 40/52 and without adjusting for seasonality of pregnancies, abortions, miscarriages, early deliveries, or multiple births. We also calculated the country-specific odds ratios (ORs) and 95% confidence intervals (CIs) for death given hospitalization separately for each risk factor (i.e., the odds of death given hospitalization and a specific risk factor), thereby comparing the odds of death in one group (e.g., among hospitalized patients with asthma) with the odds of death in all other hospitalized patients combined (e.g., among hospitalized patients without asthma) (individual country ORs not shown). We then used the <italic>I</italic><sup>2</sup> statistic to quantify the percentage of variation across countries that is due to true underlying heterogeneity in the ORs rather than chance variability <xref rid="pmed.1001053-Higgins1" ref-type="bibr">[51]</xref>. The <italic>I</italic><sup>2</sup> statistics for all examined risk factors indicated that there was substantial true underlying variation between ORs from different countries. We undertook meta-analyses with and without random effects in parallel to describe the distribution of the OR estimates across the countries for which data were available for analysis. As expected, given the heterogeneity observed between countries, the random effects meta-analysis yielded wider CIs. We conservatively report the pooled estimates from the random effects meta-analysis to describe the distribution of the OR estimates across the countries for which data were available for analysis. Underlying the random effects approach is the assumption that, although the individual countries give rise to different OR estimates, these estimates arise from a distribution with a central value, the estimate of which is referred to as the “pooled OR,” and normally distributed variability around this value. However, because of the limited number of countries in each analysis, the number of random effects is too small for diagnostics such as quantile–quantile plots to demonstrate whether the assumption of a normal distribution is valid.</p><p>Finally, with a meta-analysis of data from such diverse countries as those included in this study, reasons for heterogeneity were sought through exploratory meta-regression analyses. However, because of the limited number of countries included in the meta-regression models, and with country being the unit of analysis, the meta-regression results were not considered to be robust and so are not presented or discussed further <xref rid="pmed.1001053-Simmonds1" ref-type="bibr">[52]</xref>.</p><p>All meta-analyses and meta-regression techniques were performed using Stata version 10 (StataCorp).</p></sec></sec><sec id="s3"><title>Results</title><p>Data were collected on approximately 70,000 patients requiring hospitalization, 9,700 patients admitted to ICU, and 2,500 fatalities from 19 countries and administrative regions across the Americas, Asia, Europe, and Africa.</p><sec id="s3a"><title>Age and Gender</title><p>Approximately half of all patients included in this analysis in each level of severity were female (49.8%, 47.0%, and 44.7% of all hospitalized, ICU-admitted, and fatal H1N1pdm cases, respectively). This proportion did not vary significantly by country (<xref ref-type="table" rid="pmed-1001053-t001">Table 1</xref>). Age was associated with increased risk of poor outcome, as indicated by several different parameters. The median age of patients increased with increasing levels of severity (<xref ref-type="table" rid="pmed-1001053-t001">Table 1</xref>). Among hospitalized patients, the median age within each country ranged from 7 y in Japan to 38 y in Spain, with a median reported value among all countries that provided data (<italic>n</italic> = 14) of 19 y (IQR 14.8–27.5); among patients admitted to ICU, the median age within each country ranged from 28 y in China to 49.5 y in Hong Kong SAR, with a median value among all countries that provided data (<italic>n</italic> = 9) of 42 y (IQR 35.0–45.0); and among fatal cases, median age within each country ranged from 30 y in China to 56 y in Hong Kong SAR, with a median value among all countries that provided data (<italic>n</italic> = 13) of 46 y (IQR 37.0–42.0). When the age distribution of the proportion of patients in each level of severity was compared to the distribution in the general population, the RR was highest in the age groups <5 y and 5–14 y (RR<sub>hosp</sub> = 3.3 and 3.2, respectively) but the RR of death was highest in the age groups 50–64 y and ≥65 y (RR<sub>death</sub> = 1.6 and 1.7, respectively) (<xref ref-type="fig" rid="pmed-1001053-g001">Figure 1</xref>). The ratio of H1N1pdm deaths to hospitalizations increased with age and was the highest in the ≥65-y-old age group in all countries for which data were available (<xref ref-type="fig" rid="pmed-1001053-g002">Figure 2</xref>).</p><fig id="pmed-1001053-g001" position="float"><object-id pub-id-type="doi">10.1371/journal.pmed.1001053.g001</object-id><label>Figure 1</label><caption><title>Relative risk of hospitalization, ICU admission, and death by age group compared to the general population.</title><p>Countries included in hospitalization (A) and mortality (C) RRs: Japan, Hong Kong SAR, China, Singapore, Thailand, Chile, Germany, the Netherlands, Spain, New Zealand, Canada, US, Madagascar (hospitalizations only), and France (deaths only). Countries included in ICU admission RR (B): Japan, Hong Kong SAR, China, Singapore, Canada, Spain, the Netherlands, US, New Zealand, and South Africa. Dark line represents pooled RR; shaded lines are individual country RR.</p></caption><graphic xlink:href="pmed.1001053.g001"></graphic></fig><fig id="pmed-1001053-g002" position="float"><object-id pub-id-type="doi">10.1371/journal.pmed.1001053.g002</object-id><label>Figure 2</label><caption><title>Ratio of confirmed H1N1pdm deaths to hospitalizations for selected countries.</title><p>Countries included in figure: Spain, Singapore, China, Hong Kong SAR, Canada, the Netherlands, Thailand, Chile, Germany, Japan, US, and New Zealand. Bars represent maximum country ratio.</p></caption><graphic xlink:href="pmed.1001053.g002"></graphic></fig><table-wrap id="pmed-1001053-t001" position="float"><object-id pub-id-type="doi">10.1371/journal.pmed.1001053.t001</object-id><label>Table 1</label><caption><title>Risk factors by severity level for select countries and risk of severe disease.</title></caption><alternatives><graphic id="pmed-1001053-t001-1" xlink:href="pmed.1001053.t001"></graphic><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col></colgroup><thead><tr><td align="left" rowspan="1" colspan="1">Risk Factor<xref ref-type="table-fn" rid="nt101">a</xref></td><td colspan="6" align="left" rowspan="1">Severity Level<xref ref-type="table-fn" rid="nt102">b</xref></td><td colspan="4" align="left" rowspan="1">RR of Severe Disease (IQR)<xref ref-type="table-fn" rid="nt103">c</xref></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><italic>n</italic><xref ref-type="table-fn" rid="nt104">d</xref></td><td align="left" rowspan="1" colspan="1">Hospitalized Cases</td><td align="left" rowspan="1" colspan="1"><italic>n</italic><xref ref-type="table-fn" rid="nt104">d</xref></td><td align="left" rowspan="1" colspan="1">ICU-Admitted Cases</td><td align="left" rowspan="1" colspan="1"><italic>n</italic><xref ref-type="table-fn" rid="nt104">d</xref></td><td align="left" rowspan="1" colspan="1">Fatal Cases</td><td align="left" rowspan="1" colspan="1"><italic>n</italic><xref ref-type="table-fn" rid="nt104">d</xref></td><td align="left" rowspan="1" colspan="1">RR<sub>hosp</sub></td><td align="left" rowspan="1" colspan="1"><italic>n</italic><xref ref-type="table-fn" rid="nt104">d</xref></td><td align="left" rowspan="1" colspan="1">RR<sub>death</sub></td></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1"><bold>Age</bold></td><td align="left" rowspan="1" colspan="1">14</td><td align="left" rowspan="1" colspan="1">19.0 (14.8–27.5)</td><td align="left" rowspan="1" colspan="1">9</td><td align="left" rowspan="1" colspan="1">42.0 (35.0–45.0)</td><td align="left" rowspan="1" colspan="1">13</td><td align="left" rowspan="1" colspan="1">46.0 (37.0–52.0)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">—<xref ref-type="table-fn" rid="nt105">e</xref></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">—<xref ref-type="table-fn" rid="nt105">e</xref></td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Gender (percent female)</bold></td><td align="left" rowspan="1" colspan="1">12</td><td align="left" rowspan="1" colspan="1">49.8 (46.2–51.5)</td><td align="left" rowspan="1" colspan="1">11</td><td align="left" rowspan="1" colspan="1">47.0 (41.9–50.5)</td><td align="left" rowspan="1" colspan="1">14</td><td align="left" rowspan="1" colspan="1">44.7 (41.5–48.7)</td><td align="left" rowspan="1" colspan="1">12</td><td align="left" rowspan="1" colspan="1">1.0 (0.8–1.1)</td><td align="left" rowspan="1" colspan="1">14</td><td align="left" rowspan="1" colspan="1">0.8 (0.7–1.0)</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Chronic medical illness</bold></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Respiratory disease</td><td align="left" rowspan="1" colspan="1">12</td><td align="left" rowspan="1" colspan="1">10.3 (5.0–21.7)</td><td align="left" rowspan="1" colspan="1">11</td><td align="left" rowspan="1" colspan="1">17.2 (10.5–29.9)</td><td align="left" rowspan="1" colspan="1">16</td><td align="left" rowspan="1" colspan="1">20.4 (9.3–29.5)</td><td align="left" rowspan="1" colspan="1">5</td><td align="left" rowspan="1" colspan="1">3.3 (2.0–5.8)</td><td align="left" rowspan="1" colspan="1">8</td><td align="left" rowspan="1" colspan="1">7.8 (4.9–26.6)</td></tr><tr><td align="left" rowspan="1" colspan="1">Asthma</td><td align="left" rowspan="1" colspan="1">11</td><td align="left" rowspan="1" colspan="1">17.6 (10.0–20.4)</td><td align="left" rowspan="1" colspan="1">9</td><td align="left" rowspan="1" colspan="1">9.8 (5.6–14.3)</td><td align="left" rowspan="1" colspan="1">15</td><td align="left" rowspan="1" colspan="1">5.3 (4.0–10.6)</td><td align="left" rowspan="1" colspan="1">3</td><td align="left" rowspan="1" colspan="1">1.8 (1.2–2.6)</td><td align="left" rowspan="1" colspan="1">6</td><td align="left" rowspan="1" colspan="1">1.7 (1.5–2.1)</td></tr><tr><td align="left" rowspan="1" colspan="1">Diabetes</td><td align="left" rowspan="1" colspan="1">14</td><td align="left" rowspan="1" colspan="1">9.0 (3.5–12.6)</td><td align="left" rowspan="1" colspan="1">12</td><td align="left" rowspan="1" colspan="1">13.6 (9.3–17.3)</td><td align="left" rowspan="1" colspan="1">17</td><td align="left" rowspan="1" colspan="1">14.4 (13.0–18.0)</td><td align="left" rowspan="1" colspan="1">7</td><td align="left" rowspan="1" colspan="1">0.9 (0.5–1.7)</td><td align="left" rowspan="1" colspan="1">10</td><td align="left" rowspan="1" colspan="1">4.0 (3.1–6.9)</td></tr><tr><td align="left" rowspan="1" colspan="1">Cardiac disease</td><td align="left" rowspan="1" colspan="1">12</td><td align="left" rowspan="1" colspan="1">7.1 (3.7–10.9)</td><td align="left" rowspan="1" colspan="1">11</td><td align="left" rowspan="1" colspan="1">10.9 (8.8–15.0)</td><td align="left" rowspan="1" colspan="1">15</td><td align="left" rowspan="1" colspan="1">12.1 (10.0–16.4)</td><td align="left" rowspan="1" colspan="1">6</td><td align="left" rowspan="1" colspan="1">2.0 (1.5–2.2)</td><td align="left" rowspan="1" colspan="1">8</td><td align="left" rowspan="1" colspan="1">9.2 (5.4–10.7)</td></tr><tr><td align="left" rowspan="1" colspan="1">Renal disease</td><td align="left" rowspan="1" colspan="1">13</td><td align="left" rowspan="1" colspan="1">4.0 (2.0–5.1)</td><td align="left" rowspan="1" colspan="1">11</td><td align="left" rowspan="1" colspan="1">6.3 (3.5–8.4)</td><td align="left" rowspan="1" colspan="1">16</td><td align="left" rowspan="1" colspan="1">7.1 (5.0–8.1)</td><td align="left" rowspan="1" colspan="1">2</td><td align="left" rowspan="1" colspan="1">4.4 (4.2–4.5)</td><td align="left" rowspan="1" colspan="1">3</td><td align="left" rowspan="1" colspan="1">22.7 (21.0–25.4)</td></tr><tr><td align="left" rowspan="1" colspan="1">Liver disease</td><td align="left" rowspan="1" colspan="1">9</td><td align="left" rowspan="1" colspan="1">1.1 (0.3–2.0)</td><td align="left" rowspan="1" colspan="1">9</td><td align="left" rowspan="1" colspan="1">2.4 (0.9–5.0)</td><td align="left" rowspan="1" colspan="1">12</td><td align="left" rowspan="1" colspan="1">4.9 (2.7–6.0)</td><td align="left" rowspan="1" colspan="1">3</td><td align="left" rowspan="1" colspan="1">5.7 (3.2–15.7)</td><td align="left" rowspan="1" colspan="1">4</td><td align="left" rowspan="1" colspan="1">17.4 (11.6–28.0)</td></tr><tr><td align="left" rowspan="1" colspan="1">Neurological disease</td><td align="left" rowspan="1" colspan="1">11</td><td align="left" rowspan="1" colspan="1">4.0 (2.5–7.5)</td><td align="left" rowspan="1" colspan="1">11</td><td align="left" rowspan="1" colspan="1">7.0 (3.5–9.5)</td><td align="left" rowspan="1" colspan="1">14</td><td align="left" rowspan="1" colspan="1">13.9 (5.5–18.4)</td><td align="left" rowspan="1" colspan="1">2</td><td align="left" rowspan="1" colspan="1">1.1 (0.9–1.3)</td><td align="left" rowspan="1" colspan="1">3</td><td align="left" rowspan="1" colspan="1">13.1 (8.4–32.4)</td></tr><tr><td align="left" rowspan="1" colspan="1">Immune compromised</td><td align="left" rowspan="1" colspan="1">13</td><td align="left" rowspan="1" colspan="1">5.0 (2.0–7.2)</td><td align="left" rowspan="1" colspan="1">11</td><td align="left" rowspan="1" colspan="1">6.7 (3.2–18.4)</td><td align="left" rowspan="1" colspan="1">15</td><td align="left" rowspan="1" colspan="1">12.5 (7.9–18.4)</td><td align="left" rowspan="1" colspan="1">2</td><td align="left" rowspan="1" colspan="1">24.3 (16.1–32.6)</td><td align="left" rowspan="1" colspan="1">4</td><td align="left" rowspan="1" colspan="1">27.7 (14.0–66.5)</td></tr><tr><td align="left" rowspan="1" colspan="1">Cases with ≥1 chronic medical illnesses</td><td align="left" rowspan="1" colspan="1">14</td><td align="left" rowspan="1" colspan="1">31.1 (19.0–47.1)</td><td align="left" rowspan="1" colspan="1">10</td><td align="left" rowspan="1" colspan="1">52.3 (41.1–58.7)</td><td align="left" rowspan="1" colspan="1">16</td><td align="left" rowspan="1" colspan="1">61.8 (48.5–67.9)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">NA</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">NA</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Pregnancy</bold><xref ref-type="table-fn" rid="nt106">f</xref></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">First trimester</td><td align="left" rowspan="1" colspan="1">7</td><td align="left" rowspan="1" colspan="1">2.0 (1.0–3.5)</td><td align="left" rowspan="1" colspan="1">6</td><td align="left" rowspan="1" colspan="1">2.0 (1.5–2.5)</td><td align="left" rowspan="1" colspan="1">5</td><td align="left" rowspan="1" colspan="1">0.9 (0.0–2.5)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Second trimester</td><td align="left" rowspan="1" colspan="1">7</td><td align="left" rowspan="1" colspan="1">7.0 (3.9–9.3)</td><td align="left" rowspan="1" colspan="1">7</td><td align="left" rowspan="1" colspan="1">5.0 (1.7–6.2)</td><td align="left" rowspan="1" colspan="1">5</td><td align="left" rowspan="1" colspan="1">2.5 (0.0–14.1)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Third trimester</td><td align="left" rowspan="1" colspan="1">7</td><td align="left" rowspan="1" colspan="1">9.5 (7.6–21.3)</td><td align="left" rowspan="1" colspan="1">8</td><td align="left" rowspan="1" colspan="1">8.0 (4.0–14.6)</td><td align="left" rowspan="1" colspan="1">6</td><td align="left" rowspan="1" colspan="1">16.9 (5.1–32.0)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Unknown trimester</td><td align="left" rowspan="1" colspan="1">8</td><td align="left" rowspan="1" colspan="1">6.0 (1.9–9.3)</td><td align="left" rowspan="1" colspan="1">6</td><td align="left" rowspan="1" colspan="1">2.8 (1.7–3.2)</td><td align="left" rowspan="1" colspan="1">7</td><td align="left" rowspan="1" colspan="1">0.0 (0.0–2.1)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Total (any trimester)</td><td align="left" rowspan="1" colspan="1">10</td><td align="left" rowspan="1" colspan="1">17.4 (13.5–30.2)</td><td align="left" rowspan="1" colspan="1">9</td><td align="left" rowspan="1" colspan="1">15.0 (9.4–24.2)</td><td align="left" rowspan="1" colspan="1">11</td><td align="left" rowspan="1" colspan="1">6.9 (0.0–9.1)</td><td align="left" rowspan="1" colspan="1">10</td><td align="left" rowspan="1" colspan="1">6.8 (4.5–12.3)</td><td align="left" rowspan="1" colspan="1">11</td><td align="left" rowspan="1" colspan="1">1.9 (0.0–2.6)</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Obesity</bold></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">BMI ≥30 or clinically obese</td><td align="left" rowspan="1" colspan="1">11</td><td align="left" rowspan="1" colspan="1">6.0 (1.5–7.5)</td><td align="left" rowspan="1" colspan="1">8</td><td align="left" rowspan="1" colspan="1">11.3 (7.9–15.8)</td><td align="left" rowspan="1" colspan="1">13</td><td align="left" rowspan="1" colspan="1">12.0 (10.0–21.0)</td><td align="left" rowspan="1" colspan="1">6</td><td align="left" rowspan="1" colspan="1">0.6 (0.2–1.8)</td><td align="left" rowspan="1" colspan="1">7</td><td align="left" rowspan="1" colspan="1">1.5 (0.9–2.8)</td></tr><tr><td align="left" rowspan="1" colspan="1">BMI = 30–40</td><td align="left" rowspan="1" colspan="1">3</td><td align="left" rowspan="1" colspan="1">7.0 (4.4–16.0)</td><td align="left" rowspan="1" colspan="1">3</td><td align="left" rowspan="1" colspan="1">10.0 (6.9–18.5)</td><td align="left" rowspan="1" colspan="1">4</td><td align="left" rowspan="1" colspan="1">15.8 (7.7–25.2)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">NA</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">NA</td></tr><tr><td align="left" rowspan="1" colspan="1">BMI >40</td><td align="left" rowspan="1" colspan="1">5</td><td align="left" rowspan="1" colspan="1">3.0 (1.4–11.5)</td><td align="left" rowspan="1" colspan="1">5</td><td align="left" rowspan="1" colspan="1">5.0 (3.4–16.4)</td><td align="left" rowspan="1" colspan="1">6</td><td align="left" rowspan="1" colspan="1">15.2 (4.0–30.8)</td><td align="left" rowspan="1" colspan="1">2</td><td align="left" rowspan="1" colspan="1">15.0 (9.5–20.4)</td><td align="left" rowspan="1" colspan="1">2</td><td align="left" rowspan="1" colspan="1">36.3 (22.4–50.1)</td></tr><tr><td align="left" rowspan="1" colspan="1">BMI not measured but judged clinically obese</td><td align="left" rowspan="1" colspan="1">8</td><td align="left" rowspan="1" colspan="1">4.3 (1.8–13.3)</td><td align="left" rowspan="1" colspan="1">4</td><td align="left" rowspan="1" colspan="1">4.4 (3.4–5.3)</td><td align="left" rowspan="1" colspan="1">8</td><td align="left" rowspan="1" colspan="1">7.8 (3.8–17.3)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">NA</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">NA</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Vulnerable social/ethnic group</bold></td><td align="left" rowspan="1" colspan="1">4</td><td align="left" rowspan="1" colspan="1">5.2 (2.3–10.6)</td><td align="left" rowspan="1" colspan="1">4</td><td align="left" rowspan="1" colspan="1">5.0 (1.5–10.7)</td><td align="left" rowspan="1" colspan="1">4</td><td align="left" rowspan="1" colspan="1">10.1 (5.3–18.5)</td><td align="left" rowspan="1" colspan="1">4</td><td align="left" rowspan="1" colspan="1">1.0 (0.2–3.7)</td><td align="left" rowspan="1" colspan="1">4</td><td align="left" rowspan="1" colspan="1">2.4 (1.2–3.8)</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>TB</bold></td><td align="left" rowspan="1" colspan="1">2</td><td align="left" rowspan="1" colspan="1">1.7 (0.9–1.8)</td><td align="left" rowspan="1" colspan="1">2</td><td align="left" rowspan="1" colspan="1">1.3 (1.0–1.6)</td><td align="left" rowspan="1" colspan="1">4</td><td align="left" rowspan="1" colspan="1">2.6 (0.8–5.9)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">NA</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">NA</td></tr></tbody></table></alternatives><table-wrap-foot><fn id="nt101"><label>a</label><p>See <xref ref-type="supplementary-material" rid="pmed.1001053.s001">Text S1</xref> for definitions of risk factors.</p></fn><fn id="nt102"><label>b</label><p>All data given as median percent (IQR), except for age, which is median (in years) (IQR).</p></fn><fn id="nt103"><label>c</label><p>RR<sub>hosp</sub> is the unadjusted RR of hospitalization among H1N1pdm patients with the risk factor compared to the risk of hospitalization among H1N1pdm patients without the risk factor, and RR<sub>death</sub> is the unadjusted RR of death among H1N1pdm patients with the risk factor compared to the risk of death among H1N1pdm patients without the risk factor; range of RR provided if ≥2 countries provided data.</p></fn><fn id="nt104"><label>d</label><p>The number of countries providing data for cell directly to the right; the full list of countries that provided data for each risk factor is provided in <xref ref-type="supplementary-material" rid="pmed.1001053.s001">Text S1</xref>.</p></fn><fn id="nt105"><label>e</label><p>RR<sub>hosp</sub> and RR<sub>death</sub> calculated by age group and shown in <xref ref-type="fig" rid="pmed-1001053-g001">Figure 1</xref>.</p></fn><fn id="nt106"><label>f</label><p>Denominator is women of childbearing age in each level of severity.</p></fn><fn id="nt107"><label></label><p>NA, not assessed.</p></fn></table-wrap-foot></table-wrap></sec><sec id="s3b"><title>Chronic Illness</title><p>The proportion of H1N1pdm patients with at least one chronic medical condition generally increased with severity (median among all countries that provided data was 31.1% [<italic>n</italic> = 14], 52.3% [<italic>n</italic> = 10], and 61.8% [<italic>n</italic> = 16] of hospitalized, ICU-admitted, and fatal H1N1pdm cases, respectively (<xref ref-type="table" rid="pmed-1001053-t001">Table 1</xref>). This pattern was observed for most countries (individual country data not shown). For nearly every individual risk factor under study, the prevalence increased significantly with severity level. Chronic respiratory conditions excluding asthma (median = 10.3%, 17.2%, and 20.4%, respectively) and asthma (median = 17.6%, 9.8%, and 5.3%, respectively) were the risk factors most often reported among severe cases, followed closely by diabetes (median = 9.0%, 13.6%, and 14.4%, respectively) and chronic cardiac conditions (median = 7.1%, 10.9%, and 12.1%, respectively). The pooled OR for death given hospitalization was significantly above one for each risk factor listed, with the exception of asthma, and was highest for chronic liver disease and immunocompromised patients (<xref ref-type="fig" rid="pmed-1001053-g003">Figure 3</xref>).</p><fig id="pmed-1001053-g003" position="float"><object-id pub-id-type="doi">10.1371/journal.pmed.1001053.g003</object-id><label>Figure 3</label><caption><title>Pooled odds ratio and 95% CIs of risk of death given hospitalization for selected countries.</title><p>See <xref ref-type="supplementary-material" rid="pmed.1001053.s001">Text S1</xref> for countries included in the pooled risk factor ORs.</p></caption><graphic xlink:href="pmed.1001053.g003"></graphic></fig><p>The risk of severe disease due to H1N1 infection, including hospitalization and death, was elevated for every chronic condition for which data were available (<xref ref-type="table" rid="pmed-1001053-t001">Table 1</xref>). Notably, the RR for fatal disease due to H1N1pdm infection was elevated for asthma (median RR<sub>death</sub> = 1.7 [IQR 1.5–2.1]) and not markedly different from the RR associated with hospitalizations (median RR<sub>hosp</sub> = 1.8 [IQR 1.2–2.6]). Data on chronic illness rates in the general population were not available from enough countries to permit an assessment of the relative magnitude of risk associated with various conditions with certainty.</p></sec><sec id="s3c"><title>Pregnancy</title><p>The proportions of women of childbearing age who were hospitalized with H1N1 and were pregnant as part of all hospitalizations (median of all country data = 17.4% [IQR 13.5–30.2]), who were admitted to ICU (median of all country data = 15.0% [IQR 9.4–24.2]), and who died (median of all country data = 6.9% [0.0–9.1]) varied within each country. Pregnant women in their third trimester consistently accounted for more than half of all pregnant women among hospitalized, ICU-admitted, and fatal cases. However, with the exception of China, Thailand, and the US, the proportion of pregnant women decreased with increasing level of severity, and the pooled OR for death given hospitalization during pregnancy was below 1 (pooled OR = 0.6, 95% CI 0.2–2.5).</p><p>Pregnant women with H1N1pdm infection were at higher risk of hospitalization than women of childbearing age in the general population without H1N1pdm infection, with an unadjusted RR of hospitalization ranging from 3.5 in Germany to 25.3 in France (median RR<sub>hosp</sub> = 6.8, <italic>n</italic> = 10 countries). The unadjusted RR of death, while elevated compared to non-pregnant women in more than half of countries, was generally lower than that for hospitalization, with a median RR<sub>death</sub> of 1.9 (<italic>n</italic> = 11 countries). Four areas (Japan, the Netherlands, Hong Kong SAR, and Singapore) had a RR<sub>death</sub> of zero.</p></sec><sec id="s3d"><title>Other Risk Factors</title><p>The proportion of patients with obesity (body mass index [BMI] ≥30 or clinically judged as obese) increased with increasing disease severity and represented a median of 6%, 11.3%, and 12.0% of all hospitalized, ICU-admitted, and fatal H1N1pdm cases, respectively, and this pattern was also observed for morbid obesity (BMI >40), with 3.0%, 5.0%, and 15.2%, respectively (<xref ref-type="table" rid="pmed-1001053-t001">Table 1</xref>). However, this pattern was not consistently reported in each country. For example, France, Thailand, and China observed similar proportions of obese patients among ICU-admitted and fatal cases, while Hong Kong SAR reported a lower prevalence of obesity among fatal cases than among ICU admissions. Using data from all countries, the pooled OR for death given hospitalization for obesity (BMI ≥30 or clinically judged as obese) was 2.9 (95% CI 1.3–6.6; <xref ref-type="fig" rid="pmed-1001053-g003">Figure 3</xref>). Compared to the general population in the two countries for which data were available, the risk of death associated with morbid obesity was increased (mean RR<sub>death</sub> = 36.3 [IQR 22.4–50.1], <italic>n</italic> = 2).</p><p>Canada, Australia, and New Zealand reported significant disparities in the burden of severe H1N1pdm disease across different ethnic groups. In these three countries, indigenous population groups were overrepresented among severe H1N1pdm cases requiring hospitalization and among fatal cases. In contrast, in Thailand and Mexico, minority groups were underrepresented among severe H1N1pdm cases. Taken together, the unadjusted median RR of hospitalization for H1N1pdm patients among minority groups was 1.0 (IQR 0.2–3.7) and the median RR of death was 2.4 (IQR 1.2–3.8). TB data were reported from three countries, and the incidence increased slightly with level of severity. The disease was reported in a median of 1.7%, 1.3%, and 2.6% of hospitalized, ICU-admitted, and fatal H1N1pdm cases, respectively. We were not specifically able to evaluate HIV incidence because of a paucity of data on HIV in H1N1pdm patients.</p></sec></sec><sec id="s4"><title>Discussion</title><p>Our analysis represents to our knowledge the first comprehensive assessment of the frequency and distribution of risk factors for severe H1N1pdm infection from a global perspective, with data from approximately 70,000 patients requiring hospitalization, 9,700 patients admitted to ICU, and 2,500 fatalities from 19 countries and administrative regions around the world. Consistent with other published data, our results reaffirm that the age distribution of severe H1N1pdm cases significantly differs from that of seasonal influenza <xref rid="pmed.1001053-Pebody1" ref-type="bibr">[53]</xref>–<xref rid="pmed.1001053-Lemaitre1" ref-type="bibr">[56]</xref>. The highest rates of hospitalization per capita were in children <15 y, but the highest rates of mortality per capita were in persons over 64 y. The low apparent attack rate in the oldest age group, evidenced by low rates of hospitalization, and the high odds associated with age in the fatal group compared to hospitalized cases seems to indicate that although older adults may have a lower risk of infection, they have a significantly higher risk of death if they are infected <xref rid="pmed.1001053-Vaillant1" ref-type="bibr">[54]</xref>,<xref rid="pmed.1001053-Kamigaki1" ref-type="bibr">[57]</xref>–<xref rid="pmed.1001053-Presanis1" ref-type="bibr">[61]</xref>. It is likely that increasing prevalence of chronic risk conditions in the oldest age group contributes to this effect, but our data do not allow for quantification of this association.</p><p>Our results demonstrate that in a significant portion of severe and fatal cases, patients had preexisting chronic illness, and that the presence of chronic illness increased the likelihood of death. It was notable, however, that approximately 2/3 of hospitalized cases and 40% of fatal cases did not have any identified preexisting chronic illness. It is unknown how many of these cases had other risk factors, such as pregnancy, obesity, and substance abuse (including smoking and alcohol), for which we had insufficient information in this study. These figures are also dependent on the completeness of available data for recorded risk factors. As with seasonal influenza, the most common underlying chronic conditions among hospitalized patients were respiratory disease, asthma, cardiac disease, and diabetes. Interestingly, we found that although asthma was frequently associated with both hospitalization and death in most countries, with an increased RR for both, the OR for death given hospitalization suggested that a higher proportion of hospitalized cases survived compared to patients with other conditions. This may represent the occurrence of manageable influenza-induced exacerbations of asthma prompting admission that do not progress to viral pneumonia or other fatal complications, and may also reflect the fact that asthma tends to occur in younger age groups <xref rid="pmed.1001053-Watson1" ref-type="bibr">[62]</xref>.</p><p>Early data suggested that pregnancy might be an important risk factor for severe disease with H1N1pdm <xref rid="pmed.1001053-Louie1" ref-type="bibr">[21]</xref>,<xref rid="pmed.1001053-Denholm1" ref-type="bibr">[25]</xref>,<xref rid="pmed.1001053-Jamieson1" ref-type="bibr">[63]</xref>,<xref rid="pmed.1001053-Kumar1" ref-type="bibr">[64]</xref>. Our analysis is consistent with these reports and more recent studies <xref rid="pmed.1001053-Campbell1" ref-type="bibr">[47]</xref>,<xref rid="pmed.1001053-Creanga1" ref-type="bibr">[65]</xref>, which found an overall trend that pregnant women, mainly in their third trimester, have a higher incidence of hospitalization than the general population. Several published studies have also shown that pregnancy is associated with a higher risk of ICU admission and fatal outcome <xref rid="pmed.1001053-Vaillant1" ref-type="bibr">[54]</xref>,<xref rid="pmed.1001053-Hanslik1" ref-type="bibr">[58]</xref>,<xref rid="pmed.1001053-The2" ref-type="bibr">[66]</xref>,<xref rid="pmed.1001053-Archer1" ref-type="bibr">[67]</xref>. In our analysis, the risk associated with pregnancy was elevated for both hospitalization and fatality compared to women of childbearing age, though the latter association was not consistently observed in every country. As with asthma, the proportion of pregnant women generally decreased with severity level for most of the countries. Our results suggest that pregnant women with H1N1pdm are approximately seven times more likely to be hospitalized and two times more likely to die than non-pregnant women with H1N1pdm. The greater risk for hospitalization than for death with H1N1pdm influenza infection during pregnancy may have resulted from a lower threshold for admitting infected pregnant women to hospital and/or a more aggressive approach to antiviral or other treatment for pregnant women. In addition, the occurrence of non-respiratory complications of pregnancy, such as hypertension, pre-eclampsia, and premature labor, provoked by H1N1pdm infection may have increased the risk of hospitalization while not resulting in death <xref rid="pmed.1001053-Siston1" ref-type="bibr">[68]</xref>. This would be consistent with published reports of case series of pregnant patients that list complications of pregnancy as a common cause of admission <xref rid="pmed.1001053-Jamieson1" ref-type="bibr">[63]</xref>,<xref rid="pmed.1001053-Jamieson2" ref-type="bibr">[69]</xref>,<xref rid="pmed.1001053-Goodnight1" ref-type="bibr">[70]</xref>. The dataset did not allow us to adjust for underlying conditions in pregnant women, and thus to distinguish between risks for healthy pregnant women, and pregnant women with underlying medical conditions; however, we believe that the results support an approach of early intervention with pregnant women who develop influenza.</p><p>Early in the 2009 pandemic, clinicians from the US reported a surprisingly high prevalence of morbid obesity, a risk factor not previously associated with severe outcomes for seasonal influenza infection, in patients with severe complications of H1N1pdm infection <xref rid="pmed.1001053-Centers5" ref-type="bibr">[71]</xref>. Subsequent studies in several countries, including the US, Mexico, Canada, Spain, Greece, France, Australia, and New Zealand, reported high proportions of obesity among ICU admissions and fatal cases <xref rid="pmed.1001053-The1" ref-type="bibr">[13]</xref>,<xref rid="pmed.1001053-Fuhrman1" ref-type="bibr">[20]</xref>,<xref rid="pmed.1001053-Hanslik1" ref-type="bibr">[58]</xref>,<xref rid="pmed.1001053-Kumar1" ref-type="bibr">[64]</xref>,<xref rid="pmed.1001053-DominguezCherit1" ref-type="bibr">[72]</xref>–<xref rid="pmed.1001053-Morgan1" ref-type="bibr">[77]</xref>. Our results provide supportive evidence that obesity may be a risk factor for severe disease, as seen in the increasing proportion of morbidly obese patients with severity level and the associated elevated OR. Our findings also suggest that morbidly obese patients with H1N1pdm are more likely to die if hospitalized; however, the results in our analysis were not consistent across all countries. The association between obesity (or morbid obesity) and severe outcomes may reflect direct causation (e.g., due to greater respiratory strain of infection on obese individuals), causation through other known risk factors (e.g., obesity causes diabetes and heart disease, which pose an increased risk for severe outcome <xref rid="pmed.1001053-Jain1" ref-type="bibr">[36]</xref>), or a noncausal association, if some other factor (e.g., genetic or dietary) caused both morbid obesity and increased risk of severe outcome. Unfortunately, our dataset did not allow us to distinguish among these nonexclusive alternatives.</p><p>Indigenous populations and ethnic minorities have been reported to experience a disproportionately high burden of severe H1N1pdm infection, particularly in the Americas <xref rid="pmed.1001053-Centers2" ref-type="bibr">[14]</xref>,<xref rid="pmed.1001053-Louie1" ref-type="bibr">[21]</xref>,<xref rid="pmed.1001053-Zarychanski1" ref-type="bibr">[23]</xref>,<xref rid="pmed.1001053-Jain1" ref-type="bibr">[36]</xref>,<xref rid="pmed.1001053-Kumar1" ref-type="bibr">[64]</xref>,<xref rid="pmed.1001053-Centers6" ref-type="bibr">[75]</xref>,<xref rid="pmed.1001053-Arizona1" ref-type="bibr">[78]</xref>–<xref rid="pmed.1001053-LaRuche1" ref-type="bibr">[80]</xref> and the Australasia-Pacific region <xref rid="pmed.1001053-Baker1" ref-type="bibr">[43]</xref>,<xref rid="pmed.1001053-LaRuche1" ref-type="bibr">[80]</xref>–<xref rid="pmed.1001053-Webb1" ref-type="bibr">[82]</xref>, similar to reports during the 1918 influenza pandemic <xref rid="pmed.1001053-Wilson1" ref-type="bibr">[83]</xref>–<xref rid="pmed.1001053-Johnson1" ref-type="bibr">[85]</xref>. Our analysis of Australian, New Zealand, and Canadian data concur with these published reports, and while compelling, were not universal. Neither Thailand nor Mexico observed a significantly increased burden of severe H1N1pdm disease among indigenous or minority populations. Our data are not sufficient to explain the observed differences in the reported risk of severe disease among minority groups, but several hypotheses have been proposed, including a higher prevalence of chronic medical conditions known to increase risk of severe influenza, delayed or reduced access to healthcare, cultural differences in healthcare-seeking behavior and approaches to health, potential differences in genetic susceptibility, and social inequalities <xref rid="pmed.1001053-Zarychanski1" ref-type="bibr">[23]</xref>,<xref rid="pmed.1001053-Arizona1" ref-type="bibr">[78]</xref>,<xref rid="pmed.1001053-LaRuche1" ref-type="bibr">[80]</xref>. More research is needed to better understand and quantify the increased risk of severe H1N1pdm disease among these groups. However, an imperfect understanding of the mechanisms of health disparities related to severe H1N1pdm disease should not impede the public health community in undertaking actions to mitigate this risk by disseminating appropriate public information, targeting outreach and prevention programs, and involving at-risk population groups in pandemic planning.</p><p>Our analysis has a number of limitations, not least of which is the wide differences in surveillance systems, case management policies, and antiviral use in the countries studied. The criteria and indications for hospital and ICU admission for certain conditions (e.g., pregnancy and asthma) and by age (e.g., pediatric patients) varied significantly by country, and may have been somewhat dependent on capacity for admission, which likely varied over time. Risk factors are also dependent on the completeness and quality of data on risk factors reported and classification of death in the absence of complete testing. These variables could lead to a bias in the estimate of these conditions among severe cases and could make direct comparisons across countries difficult. Second, our data do not consider multiple risk factors for individual H1N1pdm patients. A lack of individual-level data on underlying medical conditions of H1N1pdm patients precludes our ability to sufficiently control for confounding and therefore identify the independent contribution of individual risk factors for severe disease and death. The differences observed in risk factors for hospitalization and death among H1N1pdm patients compared to among seasonal influenza patients, and the wide range of RR values between countries may be explained by differences in age structure in the general population. Several studies have identified important differences in the proportions of underlying conditions by age among hospitalized and fatal cases, including, but not limited to, the UK <xref rid="pmed.1001053-Donaldson1" ref-type="bibr">[15]</xref>,<xref rid="pmed.1001053-Pebody1" ref-type="bibr">[53]</xref>, the US <xref rid="pmed.1001053-Jain1" ref-type="bibr">[36]</xref>, Canada <xref rid="pmed.1001053-Campbell1" ref-type="bibr">[47]</xref>, and Singapore <xref rid="pmed.1001053-Cutter1" ref-type="bibr">[39]</xref>,<xref rid="pmed.1001053-Subramony1" ref-type="bibr">[86]</xref>.</p><p>A third limitation is related to our imperfect calculation of the point prevalence of pregnancy among women of childbearing age in the general population. However, we believe that our findings of the range of RR values for hospitalization and death is valid, but may be very slightly inflated because of undercounting in the denominator. The inflationary effect of undercounting is likely greatest for pregnant women in the first trimester, as we didn't adjust for common first trimester events such as miscarriages or abortions, and in this group there is likely substantial undercounting in the numerator as well because of women not knowing they are pregnant in that period. Fourth, the data used in our analysis relied on hospital records, which were not standardized, and were likely to be incomplete or vary in quality between hospitals or countries. This poses a problem in the direct comparativeness between settings.</p><p>Despite these limitations, this analysis is the first to our knowledge to compare risk factors across a variety of countries using data from a very large number of patients, and we found a great deal of consistency for much of the data. Clearly, cardiac disease, chronic respiratory disease, and diabetes are important risk factors for severe disease that will be especially relevant for countries with high rates of these illnesses. We provide evidence to support the concern regarding obesity, particularly morbid obesity, as a risk factor, though this needs more study. We found large between-country variations for some important risk factors, most notably pregnancy, and the reasons for these differences need more study. There is evidence to suggest that the differences observed for pregnancy might represent differences in case management practices, and we believe that the available evidence supports vaccination and early intervention for pregnant women. Our study reinforces the need to identify and target high-risk groups for interventions, such as immunization, information, early medical advice, and use of antiviral medications. Experience with the 2009 H1N1 pandemic and the differences observed between countries have highlighted the need for country-specific surveillance data and global standardization of case definitions and data collection, and the usefulness of data sharing to aid policy makers in critical decision making for global influenza epidemics.</p></sec><sec sec-type="supplementary-material" id="s5"><title>Supporting Information</title><supplementary-material content-type="local-data" id="pmed.1001053.s001"><label>Text S1</label><caption><p><bold>Supplemental data and analysis.</bold></p><p>(PDF)</p></caption><media xlink:href="pmed.1001053.s001.pdf"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material></sec></body><back><ack><p>All the listed authors are members of the WHO Working Group for Risk Factors for Severe H1N1pdm Infection. The authors would like to recognize the hard work of all the individuals—including general practitioners, nurses, and other healthcare workers; municipal health centers, hospitals, virology laboratories, and reference labs; and the Ministries of Health—who provided care to H1N1pdm patients, provided data and information, and kept the public informed. The authors would like to specifically acknowledge Anna Bramley, MPH, from the Influenza Division at the Centers for Disease Control and Prevention, who managed and analyzed the US data; Marta Cortes-García, MD, MPH, from the Coordinating Centre for Health Alerts and Emergencies, who collected and managed the Spanish data; the Regional Surveillance and Alert Teams from the Autonomous Communities in Spain; Liao Qiaohong and Feng Luzhao from China Centers for Disease Control and Huai Yang from the China–U.S. Collaborative Program on Emerging and Re-Emerging Infectious Diseases, Beijing, China; Tessa van't Klooster and Tjibbe Donker from the Epidemiology and Surveillance Unit, and Leslie Isken from the Preparedness and Response Unit, for severe acute respiratory infection surveillance coordination at the Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands; and Cheryl Cohen from the National Institute for Communicable Diseases, South Africa. The authors also wish to acknowledge the six restructured and six private hospitals in Singapore that provided reports of laboratory-confirmed hospitalized H1N1pdm cases.</p><p>Finally, the authors would also like to thank Matthew Lim and Lyn Finelli for their review of the manuscript.</p></ack><fn-group><fn fn-type="COI-statement"><p>CG worked for the Ministry of Health of Chile from 1997 to August 2010, in the Department of Epidemiology. CG has been involved in the process of preparing and developing the National Pandemic Plan since 2002. During the pandemic CG was in charge of the coordination of the Executive Committee for outbreaks and health emergencies in Chile. This committee was responsible for making decisions and implementing measures for prevention and control. Also, until August 2010, CG participated in the implementation of IHR 2005 in Chile. During the pandemic, the Pan American Health Organization (PAHO) provided funds to the Ministry of Health and the Institute of Public Health for studies and improvement of epidemiological surveillance. CG was not responsible for managing these resources. PAHO also delivered primers and other supplies for the laboratory diagnosis of influenza (RT-PCR). They provided computers for influenza sentinel centers for improving the opportunity of reporting, which also included the development of a web application for online notification. CG was a member of the Review Committee on the Functioning of the International Health Regulations (2005) and on Pandemic Influenza A (H1N1), 2009, between April 2010 and April 2011. The result of the work of this committee was submitted to the World Health Assembly in May 2011. In December 2010 (29 November to 15 December) CG was part of a mission to assess the health sector response to pandemic influenza A (H1N1) in Mexico. This mission was requested by the Ministry of Health of Mexico to PAHO. Other mission members were Dr. Jarbas Barbosa (Brazil), Dr. Hande Harmanci (WHO), Dr. Juan Pablo Sarmiento (Colombia), Dr. Ronald St. John (Canada). For this work CG received airfare and per diem supplemented by the standards of PAHO. CG has been invited to present the Chilean experience during the influenza pandemic 2009 in various national and international conferences. CG currently works at the Universidad del Desarrollo (Santiago, Chile) as a teacher and researcher; also at EPI-Sur Consultants, an institution dedicated to providing advisory services and consulting in the field of international health for agencies, governments, and NGOs. EPI-Sur Consultants have worked for PAHO in the field of infectious diseases (not on influenza). VJL has received unrelated research funding from GlaxoSmithKline. JT received a travel grant from the Centers for Disease Control and Prevention (via an Influenza Cooperative Agreement Grant) to attend the “Options for the Control of Influenza VII” conference in Hong Kong, 3–7 September 2010, to present a poster entitled “Fatal pandemic influenza A(H1N1)2009 infections in HIV-infected persons, South Africa.” All other authors have declared that no competing interests exist.</p></fn><fn fn-type="financial-disclosure"><p>MDVK, CAD, and AK acknowledge funding from the Medical Research Council UK and the Bill and Melinda Gates Foundation (MDVK) for funding. 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