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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genome-Wide Association Study in <italic>BRCA1</italic> Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk</title><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="aff1"><addr-line>Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff id="aff2"><addr-line>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lee, Andrew" sort="Lee, Andrew" uniqKey="Lee A" first="Andrew" last="Lee">Andrew Lee</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Olswold, Curtis" sort="Olswold, Curtis" uniqKey="Olswold C" first="Curtis" last="Olswold">Curtis Olswold</name><affiliation><nlm:aff id="aff4"><addr-line>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kuchenbaecker, Karoline B" sort="Kuchenbaecker, Karoline B" uniqKey="Kuchenbaecker K" first="Karoline B." last="Kuchenbaecker">Karoline B. Kuchenbaecker</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation><nlm:aff id="aff5"><addr-line>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fredericksen, Zachary" sort="Fredericksen, Zachary" uniqKey="Fredericksen Z" first="Zachary" last="Fredericksen">Zachary Fredericksen</name><affiliation><nlm:aff id="aff4"><addr-line>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Barrowdale, Daniel" sort="Barrowdale, Daniel" uniqKey="Barrowdale D" first="Daniel" last="Barrowdale">Daniel Barrowdale</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M." last="Gaudet">Mia M. Gaudet</name><affiliation><nlm:aff id="aff6"><addr-line>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dicks, Ed" sort="Dicks, Ed" uniqKey="Dicks E" first="Ed" last="Dicks">Ed Dicks</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kosel, Matthew" sort="Kosel, Matthew" uniqKey="Kosel M" first="Matthew" last="Kosel">Matthew Kosel</name><affiliation><nlm:aff id="aff4"><addr-line>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name><affiliation><nlm:aff id="aff7"><addr-line>Genetics Department, Queensland Institute of Medical Research, Brisbane, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name><affiliation><nlm:aff id="aff8"><addr-line>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon–Centre Léon Bérard, Lyon, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff9"><addr-line>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lee, Adam" sort="Lee, Adam" uniqKey="Lee A" first="Adam" last="Lee">Adam Lee</name><affiliation><nlm:aff id="aff10"><addr-line>Department of Molecular Pharmacology and Experimental Therapeutics (MPET), Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bacot, Francois" sort="Bacot, Francois" uniqKey="Bacot F" first="François" last="Bacot">François Bacot</name><affiliation><nlm:aff id="aff11"><addr-line>Centre d'Innovation Génome Québec et Université McGill, Montreal, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vincent, Daniel" sort="Vincent, Daniel" uniqKey="Vincent D" first="Daniel" last="Vincent">Daniel Vincent</name><affiliation><nlm:aff id="aff11"><addr-line>Centre d'Innovation Génome Québec et Université McGill, Montreal, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B. L." last="Hogervorst">Frans B. L. Hogervorst</name><affiliation><nlm:aff id="aff12"><addr-line>Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Peock, Susan" sort="Peock, Susan" uniqKey="Peock S" first="Susan" last="Peock">Susan Peock</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation><nlm:aff id="aff13"><addr-line>Institut Curie, Department of Tumour Biology, Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff14"><addr-line>Institut Curie, INSERM U830, Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff15"><addr-line>Université Paris Descartes, Sorbonne Paris Cité, Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="aff16"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Investigators, Kconfab" sort="Investigators, Kconfab" uniqKey="Investigators K" first="Kconfab" last="Investigators">Kconfab Investigators</name><affiliation><nlm:aff id="aff17"><addr-line>Kathleen Cuningham Consortium for Research into Familial Breast Cancer–Peter MacCallum Cancer Center, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="aff18"><addr-line>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff19"><addr-line>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita Katharina" sort="Schmutzler, Rita Katharina" uniqKey="Schmutzler R" first="Rita Katharina" last="Schmutzler">Rita Katharina Schmutzler</name><affiliation><nlm:aff id="aff20"><addr-line>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M." last="Domchek">Susan M. Domchek</name><affiliation><nlm:aff id="aff22"><addr-line>Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Piedmonte, Marion" sort="Piedmonte, Marion" uniqKey="Piedmonte M" first="Marion" last="Piedmonte">Marion Piedmonte</name><affiliation><nlm:aff id="aff23"><addr-line>Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, New York, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Singer, Christian F" sort="Singer, Christian F" uniqKey="Singer C" first="Christian F." last="Singer">Christian F. Singer</name><affiliation><nlm:aff id="aff24"><addr-line>Department of Obstetrics and Gynecology, and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</addr-line></nlm:aff></affiliation></author><author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><affiliation><nlm:aff id="aff25"><addr-line>Sheba Medical Center, Tel Aviv, Israel</addr-line></nlm:aff></affiliation></author><author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name><affiliation><nlm:aff id="aff26"><addr-line>Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V. O." last="Hansen">Thomas V. O. Hansen</name><affiliation><nlm:aff id="aff28"><addr-line>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="aff29"><addr-line>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I." last="Szabo">Csilla I. Szabo</name><affiliation><nlm:aff id="aff30"><addr-line>Center for Translational Cancer Research, Department of Biological Sciences, University of Delaware, Newark, Delaware, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Blanco, Ignacio" sort="Blanco, Ignacio" uniqKey="Blanco I" first="Ignacio" last="Blanco">Ignacio Blanco</name><affiliation><nlm:aff id="aff31"><addr-line>Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL–Catalan Institute of Oncology, Barcelona, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><affiliation><nlm:aff id="aff32"><addr-line>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y." last="Karlan">Beth Y. Karlan</name><affiliation><nlm:aff id="aff33"><addr-line>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Garber, Judy" sort="Garber, Judy" uniqKey="Garber J" first="Judy" last="Garber">Judy Garber</name><affiliation><nlm:aff id="aff34"><addr-line>Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Phelan, Catherine M" sort="Phelan, Catherine M" uniqKey="Phelan C" first="Catherine M." last="Phelan">Catherine M. Phelan</name><affiliation><nlm:aff id="aff35"><addr-line>Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Weitzel, Jeffrey N" sort="Weitzel, Jeffrey N" uniqKey="Weitzel J" first="Jeffrey N." last="Weitzel">Jeffrey N. Weitzel</name><affiliation><nlm:aff id="aff36"><addr-line>Clinical Cancer Genetics (for the City of Hope Clinical Cancer Genetics Community Research Network), City of Hope, Duarte, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name><affiliation><nlm:aff id="aff37"><addr-line>Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV–IRCCS, Padua, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name><affiliation><nlm:aff id="aff38"><addr-line>Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary</addr-line></nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="aff39"><addr-line>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name><affiliation><nlm:aff id="aff40"><addr-line>Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name><affiliation><nlm:aff id="aff41"><addr-line>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research Demokritos, Aghia Paraskevi Attikis, Athens, Greece</addr-line></nlm:aff></affiliation></author><author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E." last="Goldgar">David E. Goldgar</name><affiliation><nlm:aff id="aff42"><addr-line>Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name><affiliation><nlm:aff id="aff43"><addr-line>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="aff44"><addr-line>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name><affiliation><nlm:aff id="aff45"><addr-line>Human Genetics Group, Spanish National Cancer Centre (CNIO), and Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Terry, Mary Beth" sort="Terry, Mary Beth" uniqKey="Terry M" first="Mary Beth" last="Terry">Mary Beth Terry</name><affiliation><nlm:aff id="aff46"><addr-line>Department of Epidemiology, Columbia University, New York, New York, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B." last="Daly">Mary B. Daly</name><affiliation><nlm:aff id="aff47"><addr-line>Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Van Rensburg, Elizabeth J" sort="Van Rensburg, Elizabeth J" uniqKey="Van Rensburg E" first="Elizabeth J." last="Van Rensburg">Elizabeth J. Van Rensburg</name><affiliation><nlm:aff id="aff48"><addr-line>Department of Genetics, University of Pretoria, Pretoria, South Africa</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="aff49"><addr-line>Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ramus, Susan J" sort="Ramus, Susan J" uniqKey="Ramus S" first="Susan J." last="Ramus">Susan J. Ramus</name><affiliation><nlm:aff id="aff50"><addr-line>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ewart Toland, Amanda" sort="Ewart Toland, Amanda" uniqKey="Ewart Toland A" first="Amanda" last="Ewart Toland">Amanda Ewart Toland</name><affiliation><nlm:aff id="aff51"><addr-line>Divison of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A." last="Caligo">Maria A. Caligo</name><affiliation><nlm:aff id="aff52"><addr-line>Section of Genetic Oncology, Department of Laboratory Medicine, University of Pisa and University Hospital of Pisa, Pisa, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I." last="Olopade">Olufunmilayo I. Olopade</name><affiliation><nlm:aff id="aff53"><addr-line>Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tung, Nadine" sort="Tung, Nadine" uniqKey="Tung N" first="Nadine" last="Tung">Nadine Tung</name><affiliation><nlm:aff id="aff54"><addr-line>Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Claes, Kathleen" sort="Claes, Kathleen" uniqKey="Claes K" first="Kathleen" last="Claes">Kathleen Claes</name><affiliation><nlm:aff id="aff55"><addr-line>Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium</addr-line></nlm:aff></affiliation></author><author><name sortKey="Beattie, Mary S" sort="Beattie, Mary S" uniqKey="Beattie M" first="Mary S." last="Beattie">Mary S. Beattie</name><affiliation><nlm:aff id="aff56"><addr-line>Departments of Medicine, Epidemiology, and Biostatistics, University of California San Francisco, San Francisco, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="aff57"><addr-line>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Imyanitov, Evgeny N" sort="Imyanitov, Evgeny N" uniqKey="Imyanitov E" first="Evgeny N." last="Imyanitov">Evgeny N. Imyanitov</name><affiliation><nlm:aff id="aff58"><addr-line>N. N. Petrov Institute of Oncology, St. Petersburg, Russia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tischkowitz, Marc" sort="Tischkowitz, Marc" uniqKey="Tischkowitz M" first="Marc" last="Tischkowitz">Marc Tischkowitz</name><affiliation><nlm:aff id="aff59"><addr-line>Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Janavicius, Ramunas" sort="Janavicius, Ramunas" uniqKey="Janavicius R" first="Ramunas" last="Janavicius">Ramunas Janavicius</name><affiliation><nlm:aff id="aff60"><addr-line>Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius, Lithuania</addr-line></nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name><affiliation><nlm:aff id="aff61"><addr-line>Department of Epidemiology, Cancer Prevention Institute of California, Fremont, Califoria, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kwong, Ava" sort="Kwong, Ava" uniqKey="Kwong A" first="Ava" last="Kwong">Ava Kwong</name><affiliation><nlm:aff id="aff62"><addr-line>The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong, China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Diez, Orland" sort="Diez, Orland" uniqKey="Diez O" first="Orland" last="Diez">Orland Diez</name><affiliation><nlm:aff id="aff63"><addr-line>Oncogenetics Laboratory, University Hospital Vall d'Hebron and Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Balma A, Judith" sort="Balma A, Judith" uniqKey="Balma A J" first="Judith" last="Balma A">Judith Balma A</name><affiliation><nlm:aff id="aff64"><addr-line>Department of Medical Oncology, University Hospital, Vall d'Hebron, Barcelona, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Barkardottir, Rosa B" sort="Barkardottir, Rosa B" uniqKey="Barkardottir R" first="Rosa B." last="Barkardottir">Rosa B. Barkardottir</name><affiliation><nlm:aff id="aff65"><addr-line>Department of Pathology, Landspitali University Hospital and BMC, Faculty of Medicine, University of Iceland, Reykjavik, Iceland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Arun, Banu K" sort="Arun, Banu K" uniqKey="Arun B" first="Banu K." last="Arun">Banu K. Arun</name><affiliation><nlm:aff id="aff66"><addr-line>Department of Breast Medical Oncology and Clinical Cancer Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation><nlm:aff id="aff67"><addr-line>Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Haifa, Israel</addr-line></nlm:aff></affiliation></author><author><name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo-Hwang" last="Teo">Soo-Hwang Teo</name><affiliation><nlm:aff id="aff68"><addr-line>Cancer Research Initiatives Foundation, Sime Darby Medical Centre and University Malaya Cancer Research Institute, University of Malaya, Kuala Lumpur, Malaysia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name><affiliation><nlm:aff id="aff69"><addr-line>UCLA Schools of Medicine and Public Health, Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, Los Angeles, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Campbell, Ian" sort="Campbell, Ian" uniqKey="Campbell I" first="Ian" last="Campbell">Ian Campbell</name><affiliation><nlm:aff id="aff70"><addr-line>VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Van Der Hout, Annemarie H" sort="Van Der Hout, Annemarie H" uniqKey="Van Der Hout A" first="Annemarie H." last="Van Der Hout">Annemarie H. Van Der Hout</name><affiliation><nlm:aff id="aff71"><addr-line>Department of Genetics, University Medical Center, Groningen University, Groningen, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Van Deurzen, Carolien H M" sort="Van Deurzen, Carolien H M" uniqKey="Van Deurzen C" first="Carolien H. M." last="Van Deurzen">Carolien H. M. Van Deurzen</name><affiliation><nlm:aff id="aff72"><addr-line>Department of Pathology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation><nlm:aff id="aff73"><addr-line>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="G Mez Garcia, Encarna B" sort="G Mez Garcia, Encarna B" uniqKey="G Mez Garcia E" first="Encarna B." last="G Mez Garcia">Encarna B. G Mez Garcia</name><affiliation><nlm:aff id="aff74"><addr-line>Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, MUMC, Maastricht, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Van Leeuwen, Flora E" sort="Van Leeuwen, Flora E" uniqKey="Van Leeuwen F" first="Flora E." last="Van Leeuwen">Flora E. Van Leeuwen</name><affiliation><nlm:aff id="aff75"><addr-line>Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Meijers Heijboer, Hanne E J" sort="Meijers Heijboer, Hanne E J" uniqKey="Meijers Heijboer H" first="Hanne E. J." last="Meijers-Heijboer">Hanne E. J. Meijers-Heijboer</name><affiliation><nlm:aff id="aff76"><addr-line>Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gille, Johannes J P" sort="Gille, Johannes J P" uniqKey="Gille J" first="Johannes J. P." last="Gille">Johannes J. P. Gille</name><affiliation><nlm:aff id="aff76"><addr-line>Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ausems, Margreet G E M" sort="Ausems, Margreet G E M" uniqKey="Ausems M" first="Margreet G. E. M." last="Ausems">Margreet G. E. M. Ausems</name><affiliation><nlm:aff id="aff77"><addr-line>Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Blok, Marinus J" sort="Blok, Marinus J" uniqKey="Blok M" first="Marinus J." last="Blok">Marinus J. Blok</name><affiliation><nlm:aff id="aff78"><addr-line>Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ligtenberg, Marjolijn J L" sort="Ligtenberg, Marjolijn J L" uniqKey="Ligtenberg M" first="Marjolijn J. L." last="Ligtenberg">Marjolijn J. L. Ligtenberg</name><affiliation><nlm:aff id="aff79"><addr-line>Department of Human Genetics and Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rookus, Matti A" sort="Rookus, Matti A" uniqKey="Rookus M" first="Matti A." last="Rookus">Matti A. Rookus</name><affiliation><nlm:aff id="aff75"><addr-line>Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="aff80"><addr-line>Department of Human Genetics and Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Verhoef, Senno" sort="Verhoef, Senno" uniqKey="Verhoef S" first="Senno" last="Verhoef">Senno Verhoef</name><affiliation><nlm:aff id="aff12"><addr-line>Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Van Os, Theo A M" sort="Van Os, Theo A M" uniqKey="Van Os T" first="Theo A. M." last="Van Os">Theo A. M. Van Os</name><affiliation><nlm:aff id="aff81"><addr-line>Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wijnen, Juul T" sort="Wijnen, Juul T" uniqKey="Wijnen J" first="Juul T." last="Wijnen">Juul T. Wijnen</name><affiliation><nlm:aff id="aff82"><addr-line>Department of Human Genetics and Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ellis, Steve" sort="Ellis, Steve" uniqKey="Ellis S" first="Steve" last="Ellis">Steve Ellis</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fineberg, Elena" sort="Fineberg, Elena" uniqKey="Fineberg E" first="Elena" last="Fineberg">Elena Fineberg</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Platte, Radka" sort="Platte, Radka" uniqKey="Platte R" first="Radka" last="Platte">Radka Platte</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D. Gareth" last="Evans">D. Gareth Evans</name><affiliation><nlm:aff id="aff84"><addr-line>Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Izatt, Louise" sort="Izatt, Louise" uniqKey="Izatt L" first="Louise" last="Izatt">Louise Izatt</name><affiliation><nlm:aff id="aff85"><addr-line>Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name><affiliation><nlm:aff id="aff86"><addr-line>Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Adlard, Julian" sort="Adlard, Julian" uniqKey="Adlard J" first="Julian" last="Adlard">Julian Adlard</name><affiliation><nlm:aff id="aff87"><addr-line>Yorkshire Regional Genetics Service, Leeds, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Eccles, Diana M" sort="Eccles, Diana M" uniqKey="Eccles D" first="Diana M." last="Eccles">Diana M. Eccles</name><affiliation><nlm:aff id="aff88"><addr-line>University of Southampton Faculty of Medicine, Southampton University Hospitals NHS Trust, Southampton, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cook, Jackie" sort="Cook, Jackie" uniqKey="Cook J" first="Jackie" last="Cook">Jackie Cook</name><affiliation><nlm:aff id="aff89"><addr-line>Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Brewer, Carole" sort="Brewer, Carole" uniqKey="Brewer C" first="Carole" last="Brewer">Carole Brewer</name><affiliation><nlm:aff id="aff90"><addr-line>Department of Clinical Genetics, Royal Devon and Exeter Hospital, Exeter, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Douglas, Fiona" sort="Douglas, Fiona" uniqKey="Douglas F" first="Fiona" last="Douglas">Fiona Douglas</name><affiliation><nlm:aff id="aff91"><addr-line>Institute of Genetic Medicine, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hodgson, Shirley" sort="Hodgson, Shirley" uniqKey="Hodgson S" first="Shirley" last="Hodgson">Shirley Hodgson</name><affiliation><nlm:aff id="aff92"><addr-line>Department of Clinical Genetics, St George's University of London, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Morrison, Patrick J" sort="Morrison, Patrick J" uniqKey="Morrison P" first="Patrick J." last="Morrison">Patrick J. Morrison</name><affiliation><nlm:aff id="aff93"><addr-line>Northern Ireland Regional Genetics Centre, Belfast Health and Social Care Trust, and Department of Medical Genetics, Queens University Belfast, Belfast, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Side, Lucy E" sort="Side, Lucy E" uniqKey="Side L" first="Lucy E." last="Side">Lucy E. Side</name><affiliation><nlm:aff id="aff94"><addr-line>North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust and Institute for Womens Health, University College London, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Donaldson, Alan" sort="Donaldson, Alan" uniqKey="Donaldson A" first="Alan" last="Donaldson">Alan Donaldson</name><affiliation><nlm:aff id="aff95"><addr-line>Clinical Genetics Department, St Michael's Hospital, Bristol, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Houghton, Catherine" sort="Houghton, Catherine" uniqKey="Houghton C" first="Catherine" last="Houghton">Catherine Houghton</name><affiliation><nlm:aff id="aff96"><addr-line>Cheshire and Merseyside Clinical Genetics Service, Liverpool Women's NHS Foundation Trust, Liverpool, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rogers, Mark T" sort="Rogers, Mark T" uniqKey="Rogers M" first="Mark T." last="Rogers">Mark T. Rogers</name><affiliation><nlm:aff id="aff97"><addr-line>All Wales Medical Genetics Services, University Hospital of Wales, Cardiff, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dorkins, Huw" sort="Dorkins, Huw" uniqKey="Dorkins H" first="Huw" last="Dorkins">Huw Dorkins</name><affiliation><nlm:aff id="aff98"><addr-line>North West Thames Regional Genetics Service, Kennedy-Galton Centre, Harrow, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Eason, Jacqueline" sort="Eason, Jacqueline" uniqKey="Eason J" first="Jacqueline" last="Eason">Jacqueline Eason</name><affiliation><nlm:aff id="aff99"><addr-line>Nottingham Clinical Genetics Service, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gregory, Helen" sort="Gregory, Helen" uniqKey="Gregory H" first="Helen" last="Gregory">Helen Gregory</name><affiliation><nlm:aff id="aff100"><addr-line>North of Scotland Regional Genetics Service, NHS Grampian and University of Aberdeen, Foresterhill, Aberdeen, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mccann, Emma" sort="Mccann, Emma" uniqKey="Mccann E" first="Emma" last="Mccann">Emma Mccann</name><affiliation><nlm:aff id="aff101"><addr-line>All Wales Medical Genetics Services, Glan Clwyd Hospital, Rhyl, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Murray, Alex" sort="Murray, Alex" uniqKey="Murray A" first="Alex" last="Murray">Alex Murray</name><affiliation><nlm:aff id="aff102"><addr-line>All Wales Medical Genetics Services, Singleton Hospital, Swansea, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Calender, Alain" sort="Calender, Alain" uniqKey="Calender A" first="Alain" last="Calender">Alain Calender</name><affiliation><nlm:aff id="aff8"><addr-line>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon–Centre Léon Bérard, Lyon, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hardouin, Agnes" sort="Hardouin, Agnes" uniqKey="Hardouin A" first="Agnès" last="Hardouin">Agnès Hardouin</name><affiliation><nlm:aff id="aff103"><addr-line>Centre François Baclesse, Caen, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Berthet, Pascaline" sort="Berthet, Pascaline" uniqKey="Berthet P" first="Pascaline" last="Berthet">Pascaline Berthet</name><affiliation><nlm:aff id="aff103"><addr-line>Centre François Baclesse, Caen, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Delnatte, Capucine" sort="Delnatte, Capucine" uniqKey="Delnatte C" first="Capucine" last="Delnatte">Capucine Delnatte</name><affiliation><nlm:aff id="aff104"><addr-line>Centre René Gauducheau, Nantes, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nogues, Catherine" sort="Nogues, Catherine" uniqKey="Nogues C" first="Catherine" last="Nogues">Catherine Nogues</name><affiliation><nlm:aff id="aff105"><addr-line>Oncogénétique Clinique, Hôpital René Huguenin/Institut Curie, Saint-Cloud, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lasset, Christine" sort="Lasset, Christine" uniqKey="Lasset C" first="Christine" last="Lasset">Christine Lasset</name><affiliation><nlm:aff id="aff106"><addr-line>Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff107"><addr-line>Université Lyon 1, CNRS UMR5558, Lyon, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Houdayer, Claude" sort="Houdayer, Claude" uniqKey="Houdayer C" first="Claude" last="Houdayer">Claude Houdayer</name><affiliation><nlm:aff id="aff13"><addr-line>Institut Curie, Department of Tumour Biology, Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff15"><addr-line>Université Paris Descartes, Sorbonne Paris Cité, Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Leroux, Dominique" sort="Leroux, Dominique" uniqKey="Leroux D" first="Dominique" last="Leroux">Dominique Leroux</name><affiliation><nlm:aff id="aff108"><addr-line>Department of Genetics, Centre Hospitalier Universitaire de Grenoble, Grenoble, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff109"><addr-line>Institut Albert Bonniot, Université de Grenoble, Grenoble, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rouleau, Etienne" sort="Rouleau, Etienne" uniqKey="Rouleau E" first="Etienne" last="Rouleau">Etienne Rouleau</name><affiliation><nlm:aff id="aff110"><addr-line>Laboratoire d'Oncogénétique, Hôpital René Huguenin, Institut Curie, Saint-Cloud, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Prieur, Fabienne" sort="Prieur, Fabienne" uniqKey="Prieur F" first="Fabienne" last="Prieur">Fabienne Prieur</name><affiliation><nlm:aff id="aff111"><addr-line>Service de Génétique Clinique Chromosomique et Moléculaire, Centre Hospitalier Universitaire de St Etienne, St Etienne, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Damiola, Francesca" sort="Damiola, Francesca" uniqKey="Damiola F" first="Francesca" last="Damiola">Francesca Damiola</name><affiliation><nlm:aff id="aff9"><addr-line>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sobol, Hagay" sort="Sobol, Hagay" uniqKey="Sobol H" first="Hagay" last="Sobol">Hagay Sobol</name><affiliation><nlm:aff id="aff112"><addr-line>Département Oncologie Génétique, Prévention et Dépistage, INSERM CIC-P9502, Institut Paoli-Calmettes/Université d'Aix-Marseille II, Marseille, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Coupier, Isabelle" sort="Coupier, Isabelle" uniqKey="Coupier I" first="Isabelle" last="Coupier">Isabelle Coupier</name><affiliation><nlm:aff id="aff113"><addr-line>Unité d'Oncogénétique, CHU Arnaud de Villeneuve, Montpellier, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff114"><addr-line>Unité d'Oncogénétique, CRLCC Val d'Aurelle, Montpellier, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Venat Bouvet, Laurence" sort="Venat Bouvet, Laurence" uniqKey="Venat Bouvet L" first="Laurence" last="Venat-Bouvet">Laurence Venat-Bouvet</name><affiliation><nlm:aff id="aff115"><addr-line>Department of Medical Oncology, Centre Hospitalier Universitaire Dupuytren, Limoges, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Castera, Laurent" sort="Castera, Laurent" uniqKey="Castera L" first="Laurent" last="Castera">Laurent Castera</name><affiliation><nlm:aff id="aff13"><addr-line>Institut Curie, Department of Tumour Biology, Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gauthier Villars, Marion" sort="Gauthier Villars, Marion" uniqKey="Gauthier Villars M" first="Marion" last="Gauthier-Villars">Marion Gauthier-Villars</name><affiliation><nlm:aff id="aff13"><addr-line>Institut Curie, Department of Tumour Biology, Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Leone, Melanie" sort="Leone, Melanie" uniqKey="Leone M" first="Mélanie" last="Léoné">Mélanie Léoné</name><affiliation><nlm:aff id="aff8"><addr-line>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon–Centre Léon Bérard, Lyon, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pujol, Pascal" sort="Pujol, Pascal" uniqKey="Pujol P" first="Pascal" last="Pujol">Pascal Pujol</name><affiliation><nlm:aff id="aff113"><addr-line>Unité d'Oncogénétique, CHU Arnaud de Villeneuve, Montpellier, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff116"><addr-line>INSERM 896, CRCM Val d'Aurelle, Montpellier, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name><affiliation><nlm:aff id="aff9"><addr-line>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bignon, Yves Jean" sort="Bignon, Yves Jean" uniqKey="Bignon Y" first="Yves-Jean" last="Bignon">Yves-Jean Bignon</name><affiliation><nlm:aff id="aff117"><addr-line>Département d'Oncogénétique, Centre Jean Perrin, Université de Clermont-Ferrand, Clermont-Ferrand, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zlowocka Perlowska, El Bieta" sort="Zlowocka Perlowska, El Bieta" uniqKey="Zlowocka Perlowska E" first="El Bieta" last="Złowocka-Perłowska">El Bieta Złowocka-Perłowska</name><affiliation><nlm:aff id="aff16"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name><affiliation><nlm:aff id="aff16"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="aff16"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="aff16"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jaworska, Katarzyna" sort="Jaworska, Katarzyna" uniqKey="Jaworska K" first="Katarzyna" last="Jaworska">Katarzyna Jaworska</name><affiliation><nlm:aff id="aff16"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff119"><addr-line>Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Huzarski, Tomasz" sort="Huzarski, Tomasz" uniqKey="Huzarski T" first="Tomasz" last="Huzarski">Tomasz Huzarski</name><affiliation><nlm:aff id="aff16"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name><affiliation><nlm:aff id="aff7"><addr-line>Genetics Department, Queensland Institute of Medical Research, Brisbane, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Viel, Alessandra" sort="Viel, Alessandra" uniqKey="Viel A" first="Alessandra" last="Viel">Alessandra Viel</name><affiliation><nlm:aff id="aff120"><addr-line>Division of Experimental Oncology 1, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Peissel, Bernard" sort="Peissel, Bernard" uniqKey="Peissel B" first="Bernard" last="Peissel">Bernard Peissel</name><affiliation><nlm:aff id="aff121"><addr-line>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name><affiliation><nlm:aff id="aff122"><addr-line>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Melloni, Giulia" sort="Melloni, Giulia" uniqKey="Melloni G" first="Giulia" last="Melloni">Giulia Melloni</name><affiliation><nlm:aff id="aff121"><addr-line>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ottini, Laura" sort="Ottini, Laura" uniqKey="Ottini L" first="Laura" last="Ottini">Laura Ottini</name><affiliation><nlm:aff id="aff123"><addr-line>Department of Molecular Medicine, Sapienza University, Rome, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Papi, Laura" sort="Papi, Laura" uniqKey="Papi L" first="Laura" last="Papi">Laura Papi</name><affiliation><nlm:aff id="aff124"><addr-line>Unit of Medical Genetics, Department of Clinical Physiopathology, University of Florence, Firenze, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Varesco, Liliana" sort="Varesco, Liliana" uniqKey="Varesco L" first="Liliana" last="Varesco">Liliana Varesco</name><affiliation><nlm:aff id="aff125"><addr-line>Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, IRCCS AOU San Martino–IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tibiletti, Maria Grazia" sort="Tibiletti, Maria Grazia" uniqKey="Tibiletti M" first="Maria Grazia" last="Tibiletti">Maria Grazia Tibiletti</name><affiliation><nlm:aff id="aff126"><addr-line>UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria, Varese, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="aff18"><addr-line>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff19"><addr-line>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Volorio, Sara" sort="Volorio, Sara" uniqKey="Volorio S" first="Sara" last="Volorio">Sara Volorio</name><affiliation><nlm:aff id="aff127"><addr-line>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare and Cogentech Cancer Genetic Test Laboratory, Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="aff121"><addr-line>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pensotti, Valeria" sort="Pensotti, Valeria" uniqKey="Pensotti V" first="Valeria" last="Pensotti">Valeria Pensotti</name><affiliation><nlm:aff id="aff127"><addr-line>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare and Cogentech Cancer Genetic Test Laboratory, Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name><affiliation><nlm:aff id="aff128"><addr-line>University Hospital of Schleswig-Holstein/University Kiel, Kiel, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name><affiliation><nlm:aff id="aff129"><addr-line>Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Deissler, Helmut" sort="Deissler, Helmut" uniqKey="Deissler H" first="Helmut" last="Deissler">Helmut Deissler</name><affiliation><nlm:aff id="aff130"><addr-line>University Hospital Ulm, Ulm, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gadzicki, Dorothea" sort="Gadzicki, Dorothea" uniqKey="Gadzicki D" first="Dorothea" last="Gadzicki">Dorothea Gadzicki</name><affiliation><nlm:aff id="aff131"><addr-line>Hannover Medical School, Hanover, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gehrig, Andrea" sort="Gehrig, Andrea" uniqKey="Gehrig A" first="Andrea" last="Gehrig">Andrea Gehrig</name><affiliation><nlm:aff id="aff132"><addr-line>Institute of Human Genetics, University of Würzburg, Wurzburg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kast, Karin" sort="Kast, Karin" uniqKey="Kast K" first="Karin" last="Kast">Karin Kast</name><affiliation><nlm:aff id="aff133"><addr-line>Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rhiem, Kerstin" sort="Rhiem, Kerstin" uniqKey="Rhiem K" first="Kerstin" last="Rhiem">Kerstin Rhiem</name><affiliation><nlm:aff id="aff20"><addr-line>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="aff134"><addr-line>Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name><affiliation><nlm:aff id="aff135"><addr-line>Department of Obstetrics and Gynaecology, University Medical Center Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ditsch, Nina" sort="Ditsch, Nina" uniqKey="Ditsch N" first="Nina" last="Ditsch">Nina Ditsch</name><affiliation><nlm:aff id="aff136"><addr-line>Department of Gynaecology and Obstetrics, University of Munich, Munich, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Plendl, Hansjoerg" sort="Plendl, Hansjoerg" uniqKey="Plendl H" first="Hansjoerg" last="Plendl">Hansjoerg Plendl</name><affiliation><nlm:aff id="aff137"><addr-line>Institute of Human Genetics, University Hospital of Schleswig-Holstein, University of Kiel, Kiel, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Preisler Adams, Sabine" sort="Preisler Adams, Sabine" uniqKey="Preisler Adams S" first="Sabine" last="Preisler-Adams">Sabine Preisler-Adams</name><affiliation><nlm:aff id="aff138"><addr-line>Institute of Human Genetics, Münster, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Engert, Stefanie" sort="Engert, Stefanie" uniqKey="Engert S" first="Stefanie" last="Engert">Stefanie Engert</name><affiliation><nlm:aff id="aff134"><addr-line>Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name><affiliation><nlm:aff id="aff139"><addr-line>Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Varon Mateeva, Raymonda" sort="Varon Mateeva, Raymonda" uniqKey="Varon Mateeva R" first="Raymonda" last="Varon-Mateeva">Raymonda Varon-Mateeva</name><affiliation><nlm:aff id="aff140"><addr-line>Institute of Medical and Human Genetics, Berlin, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wappenschmidt, Barbara" sort="Wappenschmidt, Barbara" uniqKey="Wappenschmidt B" first="Barbara" last="Wappenschmidt">Barbara Wappenschmidt</name><affiliation><nlm:aff id="aff20"><addr-line>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Weber, Bernhard H F" sort="Weber, Bernhard H F" uniqKey="Weber B" first="Bernhard H. F." last="Weber">Bernhard H. F. Weber</name><affiliation><nlm:aff id="aff141"><addr-line>Institute of Human Genetics, University of Regensburg, Regensburg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Arver, Brita" sort="Arver, Brita" uniqKey="Arver B" first="Brita" last="Arver">Brita Arver</name><affiliation><nlm:aff id="aff142"><addr-line>Department of Oncology and Pathology, Karolinska University Hospital, Stockholm, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stenmark Askmalm, Marie" sort="Stenmark Askmalm, Marie" uniqKey="Stenmark Askmalm M" first="Marie" last="Stenmark-Askmalm">Marie Stenmark-Askmalm</name><affiliation><nlm:aff id="aff143"><addr-line>Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Loman, Niklas" sort="Loman, Niklas" uniqKey="Loman N" first="Niklas" last="Loman">Niklas Loman</name><affiliation><nlm:aff id="aff144"><addr-line>Department of Oncology, Lund University Hospital, Lund, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rosenquist, Richard" sort="Rosenquist, Richard" uniqKey="Rosenquist R" first="Richard" last="Rosenquist">Richard Rosenquist</name><affiliation><nlm:aff id="aff145"><addr-line>Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Einbeigi, Zakaria" sort="Einbeigi, Zakaria" uniqKey="Einbeigi Z" first="Zakaria" last="Einbeigi">Zakaria Einbeigi</name><affiliation><nlm:aff id="aff146"><addr-line>Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><affiliation><nlm:aff id="aff147"><addr-line>Abramson Cancer Center and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rebbeck, Timothy R" sort="Rebbeck, Timothy R" uniqKey="Rebbeck T" first="Timothy R." last="Rebbeck">Timothy R. Rebbeck</name><affiliation><nlm:aff id="aff148"><addr-line>Abramson Cancer Center and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Blank, Stephanie V" sort="Blank, Stephanie V" uniqKey="Blank S" first="Stephanie V." last="Blank">Stephanie V. Blank</name><affiliation><nlm:aff id="aff149"><addr-line>NYU Women's Cancer Program, New York University School of Medicine, New York, New York, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cohn, David E" sort="Cohn, David E" uniqKey="Cohn D" first="David E." last="Cohn">David E. Cohn</name><affiliation><nlm:aff id="aff150"><addr-line>Ohio State University, Columbus Cancer Council, Columbus, Ohio, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rodriguez, Gustavo C" sort="Rodriguez, Gustavo C" uniqKey="Rodriguez G" first="Gustavo C." last="Rodriguez">Gustavo C. Rodriguez</name><affiliation><nlm:aff id="aff151"><addr-line>Division of Gynecologic Oncology, North Shore University Health System, University of Chicago, Evanston, Illinois, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Small, Laurie" sort="Small, Laurie" uniqKey="Small L" first="Laurie" last="Small">Laurie Small</name><affiliation><nlm:aff id="aff152"><addr-line>Maine Medical Center, Maine Women's Surgery and Cancer Centre, Scarborough, Maine, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Friedlander, Michael" sort="Friedlander, Michael" uniqKey="Friedlander M" first="Michael" last="Friedlander">Michael Friedlander</name><affiliation><nlm:aff id="aff153"><addr-line>ANZ GOTG Coordinating Centre, Australia New Zealand GOG, Camperdown, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bae Jump, Victoria L" sort="Bae Jump, Victoria L" uniqKey="Bae Jump V" first="Victoria L." last="Bae-Jump">Victoria L. Bae-Jump</name><affiliation><nlm:aff id="aff154"><addr-line>The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fink Retter, Anneliese" sort="Fink Retter, Anneliese" uniqKey="Fink Retter A" first="Anneliese" last="Fink-Retter">Anneliese Fink-Retter</name><affiliation><nlm:aff id="aff24"><addr-line>Department of Obstetrics and Gynecology, and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rappaport, Christine" sort="Rappaport, Christine" uniqKey="Rappaport C" first="Christine" last="Rappaport">Christine Rappaport</name><affiliation><nlm:aff id="aff24"><addr-line>Department of Obstetrics and Gynecology, and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gschwantler Kaulich, Daphne" sort="Gschwantler Kaulich, Daphne" uniqKey="Gschwantler Kaulich D" first="Daphne" last="Gschwantler-Kaulich">Daphne Gschwantler-Kaulich</name><affiliation><nlm:aff id="aff24"><addr-line>Department of Obstetrics and Gynecology, and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pfeiler, Georg" sort="Pfeiler, Georg" uniqKey="Pfeiler G" first="Georg" last="Pfeiler">Georg Pfeiler</name><affiliation><nlm:aff id="aff24"><addr-line>Department of Obstetrics and Gynecology, and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tea, Muy Kheng" sort="Tea, Muy Kheng" uniqKey="Tea M" first="Muy-Kheng" last="Tea">Muy-Kheng Tea</name><affiliation><nlm:aff id="aff24"><addr-line>Department of Obstetrics and Gynecology, and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M." last="Lindor">Noralane M. Lindor</name><affiliation><nlm:aff id="aff155"><addr-line>Department of Health Science Research, Mayo Clinic Arizona, Scottsdale, Arizona, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kaufman, Bella" sort="Kaufman, Bella" uniqKey="Kaufman B" first="Bella" last="Kaufman">Bella Kaufman</name><affiliation><nlm:aff id="aff25"><addr-line>Sheba Medical Center, Tel Aviv, Israel</addr-line></nlm:aff></affiliation></author><author><name sortKey="Shimon Paluch, Shani" sort="Shimon Paluch, Shani" uniqKey="Shimon Paluch S" first="Shani" last="Shimon Paluch">Shani Shimon Paluch</name><affiliation><nlm:aff id="aff25"><addr-line>Sheba Medical Center, Tel Aviv, Israel</addr-line></nlm:aff></affiliation></author><author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name><affiliation><nlm:aff id="aff25"><addr-line>Sheba Medical Center, Tel Aviv, Israel</addr-line></nlm:aff></affiliation></author><author><name sortKey="Skytte, Anne Bine" sort="Skytte, Anne Bine" uniqKey="Skytte A" first="Anne-Bine" last="Skytte">Anne-Bine Skytte</name><affiliation><nlm:aff id="aff156"><addr-line>Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gerdes, Anne Marie" sort="Gerdes, Anne Marie" uniqKey="Gerdes A" first="Anne-Marie" last="Gerdes">Anne-Marie Gerdes</name><affiliation><nlm:aff id="aff157"><addr-line>Department of Clincial Genetics, Rigshospitalet, København, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pedersen, Inge Sokilde" sort="Pedersen, Inge Sokilde" uniqKey="Pedersen I" first="Inge Sokilde" last="Pedersen">Inge Sokilde Pedersen</name><affiliation><nlm:aff id="aff158"><addr-line>Section of Molecular Diagnostics, Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Moeller, Sanne Traasdahl" sort="Moeller, Sanne Traasdahl" uniqKey="Moeller S" first="Sanne Traasdahl" last="Moeller">Sanne Traasdahl Moeller</name><affiliation><nlm:aff id="aff26"><addr-line>Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kruse, Torben A" sort="Kruse, Torben A" uniqKey="Kruse T" first="Torben A." last="Kruse">Torben A. Kruse</name><affiliation><nlm:aff id="aff26"><addr-line>Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jensen, Uffe Birk" sort="Jensen, Uffe Birk" uniqKey="Jensen U" first="Uffe Birk" last="Jensen">Uffe Birk Jensen</name><affiliation><nlm:aff id="aff159"><addr-line>Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name><affiliation><nlm:aff id="aff160"><addr-line>Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sarrel, Kara" sort="Sarrel, Kara" uniqKey="Sarrel K" first="Kara" last="Sarrel">Kara Sarrel</name><affiliation><nlm:aff id="aff160"><addr-line>Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Robson, Mark" sort="Robson, Mark" uniqKey="Robson M" first="Mark" last="Robson">Mark Robson</name><affiliation><nlm:aff id="aff160"><addr-line>Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kauff, Noah" sort="Kauff, Noah" uniqKey="Kauff N" first="Noah" last="Kauff">Noah Kauff</name><affiliation><nlm:aff id="aff160"><addr-line>Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="aff161"><addr-line>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff162"><addr-line>Department of Laboratory Medicine, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="aff27"><addr-line>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ozcelik, Hilmi" sort="Ozcelik, Hilmi" uniqKey="Ozcelik H" first="Hilmi" last="Ozcelik">Hilmi Ozcelik</name><affiliation><nlm:aff id="aff39"><addr-line>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff161"><addr-line>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ejlertsen, Bent" sort="Ejlertsen, Bent" uniqKey="Ejlertsen B" first="Bent" last="Ejlertsen">Bent Ejlertsen</name><affiliation><nlm:aff id="aff163"><addr-line>Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nielsen, Finn C" sort="Nielsen, Finn C" uniqKey="Nielsen F" first="Finn C." last="Nielsen">Finn C. Nielsen</name><affiliation><nlm:aff id="aff28"><addr-line>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="J Nson, Lars" sort="J Nson, Lars" uniqKey="J Nson L" first="Lars" last="J Nson">Lars J Nson</name><affiliation><nlm:aff id="aff28"><addr-line>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Andersen, Mette K" sort="Andersen, Mette K" uniqKey="Andersen M" first="Mette K." last="Andersen">Mette K. Andersen</name><affiliation><nlm:aff id="aff164"><addr-line>Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ding, Yuan Chun" sort="Ding, Yuan Chun" uniqKey="Ding Y" first="Yuan Chun" last="Ding">Yuan Chun Ding</name><affiliation><nlm:aff id="aff29"><addr-line>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Steele, Linda" sort="Steele, Linda" uniqKey="Steele L" first="Linda" last="Steele">Linda Steele</name><affiliation><nlm:aff id="aff29"><addr-line>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name><affiliation><nlm:aff id="aff165"><addr-line>Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic</addr-line></nlm:aff></affiliation></author><author><name sortKey="Teule, Alex" sort="Teule, Alex" uniqKey="Teule A" first="Alex" last="Teulé">Alex Teulé</name><affiliation><nlm:aff id="aff31"><addr-line>Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL–Catalan Institute of Oncology, Barcelona, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lazaro, Conxi" sort="Lazaro, Conxi" uniqKey="Lazaro C" first="Conxi" last="Lazaro">Conxi Lazaro</name><affiliation><nlm:aff id="aff166"><addr-line>Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL–Catalan Institute of Oncology, Barcelona, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Brunet, Joan" sort="Brunet, Joan" uniqKey="Brunet J" first="Joan" last="Brunet">Joan Brunet</name><affiliation><nlm:aff id="aff167"><addr-line>Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI–Catalan Institute of Oncology, Girona, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pujana, Miquel Angel" sort="Pujana, Miquel Angel" uniqKey="Pujana M" first="Miquel Angel" last="Pujana">Miquel Angel Pujana</name><affiliation><nlm:aff id="aff168"><addr-line>Translational Research Laboratory, Breast Cancer and Systems Biology Unit, IDIBELL–Catalan Institute of Oncology, Barcelona, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L." last="Mai">Phuong L. Mai</name><affiliation><nlm:aff id="aff32"><addr-line>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Loud, Jennifer T" sort="Loud, Jennifer T" uniqKey="Loud J" first="Jennifer T." last="Loud">Jennifer T. Loud</name><affiliation><nlm:aff id="aff32"><addr-line>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Walsh, Christine" sort="Walsh, Christine" uniqKey="Walsh C" first="Christine" last="Walsh">Christine Walsh</name><affiliation><nlm:aff id="aff33"><addr-line>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lester, Jenny" sort="Lester, Jenny" uniqKey="Lester J" first="Jenny" last="Lester">Jenny Lester</name><affiliation><nlm:aff id="aff33"><addr-line>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Orsulic, Sandra" sort="Orsulic, Sandra" uniqKey="Orsulic S" first="Sandra" last="Orsulic">Sandra Orsulic</name><affiliation><nlm:aff id="aff33"><addr-line>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Narod, Steven A" sort="Narod, Steven A" uniqKey="Narod S" first="Steven A." last="Narod">Steven A. Narod</name><affiliation><nlm:aff id="aff169"><addr-line>Women's College Research Institute, University of Toronto, Toronto, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Herzog, Josef" sort="Herzog, Josef" uniqKey="Herzog J" first="Josef" last="Herzog">Josef Herzog</name><affiliation><nlm:aff id="aff36"><addr-line>Clinical Cancer Genetics (for the City of Hope Clinical Cancer Genetics Community Research Network), City of Hope, Duarte, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sand, Sharon R" sort="Sand, Sharon R" uniqKey="Sand S" first="Sharon R." last="Sand">Sharon R. Sand</name><affiliation><nlm:aff id="aff36"><addr-line>Clinical Cancer Genetics (for the City of Hope Clinical Cancer Genetics Community Research Network), City of Hope, Duarte, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tognazzo, Silvia" sort="Tognazzo, Silvia" uniqKey="Tognazzo S" first="Silvia" last="Tognazzo">Silvia Tognazzo</name><affiliation><nlm:aff id="aff37"><addr-line>Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV–IRCCS, Padua, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Agata, Simona" sort="Agata, Simona" uniqKey="Agata S" first="Simona" last="Agata">Simona Agata</name><affiliation><nlm:aff id="aff37"><addr-line>Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV–IRCCS, Padua, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vaszko, Tibor" sort="Vaszko, Tibor" uniqKey="Vaszko T" first="Tibor" last="Vaszko">Tibor Vaszko</name><affiliation><nlm:aff id="aff38"><addr-line>Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary</addr-line></nlm:aff></affiliation></author><author><name sortKey="Weaver, Joellen" sort="Weaver, Joellen" uniqKey="Weaver J" first="Joellen" last="Weaver">Joellen Weaver</name><affiliation><nlm:aff id="aff170"><addr-line>Biosample Repository, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stavropoulou, Alexandra V" sort="Stavropoulou, Alexandra V" uniqKey="Stavropoulou A" first="Alexandra V." last="Stavropoulou">Alexandra V. Stavropoulou</name><affiliation><nlm:aff id="aff41"><addr-line>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research Demokritos, Aghia Paraskevi Attikis, Athens, Greece</addr-line></nlm:aff></affiliation></author><author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S." last="Buys">Saundra S. Buys</name><affiliation><nlm:aff id="aff171"><addr-line>Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Romero, Atocha" sort="Romero, Atocha" uniqKey="Romero A" first="Atocha" last="Romero">Atocha Romero</name><affiliation><nlm:aff id="aff43"><addr-line>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="De La Hoya, Miguel" sort="De La Hoya, Miguel" uniqKey="De La Hoya M" first="Miguel" last="De La Hoya">Miguel De La Hoya</name><affiliation><nlm:aff id="aff43"><addr-line>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="aff172"><addr-line>Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name><affiliation><nlm:aff id="aff44"><addr-line>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Duran, Mercedes" sort="Duran, Mercedes" uniqKey="Duran M" first="Mercedes" last="Duran">Mercedes Duran</name><affiliation><nlm:aff id="aff173"><addr-line>Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM–UVA), Valladolid, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chung, Wendy K" sort="Chung, Wendy K" uniqKey="Chung W" first="Wendy K." last="Chung">Wendy K. Chung</name><affiliation><nlm:aff id="aff174"><addr-line>Departments of Pediatrics and Medicine, Columbia University, New York, New York, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lasa, Adriana" sort="Lasa, Adriana" uniqKey="Lasa A" first="Adriana" last="Lasa">Adriana Lasa</name><affiliation><nlm:aff id="aff175"><addr-line>Genetics Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dorfling, Cecilia M" sort="Dorfling, Cecilia M" uniqKey="Dorfling C" first="Cecilia M." last="Dorfling">Cecilia M. Dorfling</name><affiliation><nlm:aff id="aff48"><addr-line>Department of Genetics, University of Pretoria, Pretoria, South Africa</addr-line></nlm:aff></affiliation></author><author><name sortKey="Miron, Alexander" sort="Miron, Alexander" uniqKey="Miron A" first="Alexander" last="Miron">Alexander Miron</name><affiliation><nlm:aff id="aff176"><addr-line>Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="aff178"><addr-line>Human Genetics Group and Genotyping Unit, Spanish National Cancer Centre (CNIO), and Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Senter, Leigha" sort="Senter, Leigha" uniqKey="Senter L" first="Leigha" last="Senter">Leigha Senter</name><affiliation><nlm:aff id="aff179"><addr-line>Divison of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Huo, Dezheng" sort="Huo, Dezheng" uniqKey="Huo D" first="Dezheng" last="Huo">Dezheng Huo</name><affiliation><nlm:aff id="aff53"><addr-line>Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chan, Salina B" sort="Chan, Salina B" uniqKey="Chan S" first="Salina B." last="Chan">Salina B. Chan</name><affiliation><nlm:aff id="aff180"><addr-line>Cancer Risk Program, Helen Diller Family Cancer Center, University of California San Francisco, San Francisco, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sokolenko, Anna P" sort="Sokolenko, Anna P" uniqKey="Sokolenko A" first="Anna P." last="Sokolenko">Anna P. Sokolenko</name><affiliation><nlm:aff id="aff58"><addr-line>N. N. Petrov Institute of Oncology, St. Petersburg, Russia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chiquette, Jocelyne" sort="Chiquette, Jocelyne" uniqKey="Chiquette J" first="Jocelyne" last="Chiquette">Jocelyne Chiquette</name><affiliation><nlm:aff id="aff181"><addr-line>Unité de Recherche en Santé des Populations, Centre des Maladies du Sein Deschênes-Fabia, Centre de Recherche FRSQ du Centre Hospitalier Affilié Universitaire de Québec, Québec, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tihomirova, Laima" sort="Tihomirova, Laima" uniqKey="Tihomirova L" first="Laima" last="Tihomirova">Laima Tihomirova</name><affiliation><nlm:aff id="aff182"><addr-line>Latvian Biomedical Research and Study Centre, Riga, Latvia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Friebel, Tara M" sort="Friebel, Tara M" uniqKey="Friebel T" first="Tara M." last="Friebel">Tara M. Friebel</name><affiliation><nlm:aff id="aff183"><addr-line>University of Pennsylvania, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Agnarsson, Bjarni A" sort="Agnarsson, Bjarni A" uniqKey="Agnarsson B" first="Bjarni A." last="Agnarsson">Bjarni A. Agnarsson</name><affiliation><nlm:aff id="aff184"><addr-line>Landspitali University Hospital and University of Iceland School of Medicine, Reykjavik, Iceland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lu, Karen H" sort="Lu, Karen H" uniqKey="Lu K" first="Karen H." last="Lu">Karen H. Lu</name><affiliation><nlm:aff id="aff66"><addr-line>Department of Breast Medical Oncology and Clinical Cancer Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lejbkowicz, Flavio" sort="Lejbkowicz, Flavio" uniqKey="Lejbkowicz F" first="Flavio" last="Lejbkowicz">Flavio Lejbkowicz</name><affiliation><nlm:aff id="aff185"><addr-line>Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel</addr-line></nlm:aff></affiliation></author><author><name sortKey="James, Paul A" sort="James, Paul A" uniqKey="James P" first="Paul A." last="James">Paul A. James</name><affiliation><nlm:aff id="aff186"><addr-line>Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="aff187"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="aff188"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tessier, Daniel" sort="Tessier, Daniel" uniqKey="Tessier D" first="Daniel" last="Tessier">Daniel Tessier</name><affiliation><nlm:aff id="aff11"><addr-line>Centre d'Innovation Génome Québec et Université McGill, Montreal, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cunningham, Julie" sort="Cunningham, Julie" uniqKey="Cunningham J" first="Julie" last="Cunningham">Julie Cunningham</name><affiliation><nlm:aff id="aff1"><addr-line>Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Slager, Susan L" sort="Slager, Susan L" uniqKey="Slager S" first="Susan L." last="Slager">Susan L. Slager</name><affiliation><nlm:aff id="aff4"><addr-line>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wang, Chen" sort="Wang, Chen" uniqKey="Wang C" first="Chen" last="Wang">Chen Wang</name><affiliation><nlm:aff id="aff4"><addr-line>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hart, Steven" sort="Hart, Steven" uniqKey="Hart S" first="Steven" last="Hart">Steven Hart</name><affiliation><nlm:aff id="aff4"><addr-line>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stevens, Kristen" sort="Stevens, Kristen" uniqKey="Stevens K" first="Kristen" last="Stevens">Kristen Stevens</name><affiliation><nlm:aff id="aff1"><addr-line>Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="aff5"><addr-line>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pastinen, Tomi" sort="Pastinen, Tomi" uniqKey="Pastinen T" first="Tomi" last="Pastinen">Tomi Pastinen</name><affiliation><nlm:aff id="aff189"><addr-line>Department of Human Genetics, McGill University and Génome Québec Innovation Centre, McGill University, Montréal, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pankratz, Vernon S" sort="Pankratz, Vernon S" uniqKey="Pankratz V" first="Vernon S." last="Pankratz">Vernon S. Pankratz</name><affiliation><nlm:aff id="aff4"><addr-line>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><nlm:aff id="aff160"><addr-line>Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="aff7"><addr-line>Genetics Department, Queensland Institute of Medical Research, Brisbane, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23544013</idno><idno type="pmc">3609646</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609646</idno><idno type="RBID">PMC:3609646</idno><idno type="doi">10.1371/journal.pgen.1003212</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">002886</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002886</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-Wide Association Study in <italic>BRCA1</italic> Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk</title><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="aff1"><addr-line>Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff id="aff2"><addr-line>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lee, Andrew" sort="Lee, Andrew" uniqKey="Lee A" first="Andrew" last="Lee">Andrew Lee</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Olswold, Curtis" sort="Olswold, Curtis" uniqKey="Olswold C" first="Curtis" last="Olswold">Curtis Olswold</name><affiliation><nlm:aff id="aff4"><addr-line>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kuchenbaecker, Karoline B" sort="Kuchenbaecker, Karoline B" uniqKey="Kuchenbaecker K" first="Karoline B." last="Kuchenbaecker">Karoline B. Kuchenbaecker</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation><nlm:aff id="aff5"><addr-line>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fredericksen, Zachary" sort="Fredericksen, Zachary" uniqKey="Fredericksen Z" first="Zachary" last="Fredericksen">Zachary Fredericksen</name><affiliation><nlm:aff id="aff4"><addr-line>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Barrowdale, Daniel" sort="Barrowdale, Daniel" uniqKey="Barrowdale D" first="Daniel" last="Barrowdale">Daniel Barrowdale</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M." last="Gaudet">Mia M. Gaudet</name><affiliation><nlm:aff id="aff6"><addr-line>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dicks, Ed" sort="Dicks, Ed" uniqKey="Dicks E" first="Ed" last="Dicks">Ed Dicks</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kosel, Matthew" sort="Kosel, Matthew" uniqKey="Kosel M" first="Matthew" last="Kosel">Matthew Kosel</name><affiliation><nlm:aff id="aff4"><addr-line>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name><affiliation><nlm:aff id="aff7"><addr-line>Genetics Department, Queensland Institute of Medical Research, Brisbane, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name><affiliation><nlm:aff id="aff8"><addr-line>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon–Centre Léon Bérard, Lyon, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff9"><addr-line>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lee, Adam" sort="Lee, Adam" uniqKey="Lee A" first="Adam" last="Lee">Adam Lee</name><affiliation><nlm:aff id="aff10"><addr-line>Department of Molecular Pharmacology and Experimental Therapeutics (MPET), Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bacot, Francois" sort="Bacot, Francois" uniqKey="Bacot F" first="François" last="Bacot">François Bacot</name><affiliation><nlm:aff id="aff11"><addr-line>Centre d'Innovation Génome Québec et Université McGill, Montreal, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vincent, Daniel" sort="Vincent, Daniel" uniqKey="Vincent D" first="Daniel" last="Vincent">Daniel Vincent</name><affiliation><nlm:aff id="aff11"><addr-line>Centre d'Innovation Génome Québec et Université McGill, Montreal, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B. L." last="Hogervorst">Frans B. L. Hogervorst</name><affiliation><nlm:aff id="aff12"><addr-line>Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Peock, Susan" sort="Peock, Susan" uniqKey="Peock S" first="Susan" last="Peock">Susan Peock</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation><nlm:aff id="aff13"><addr-line>Institut Curie, Department of Tumour Biology, Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff14"><addr-line>Institut Curie, INSERM U830, Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff15"><addr-line>Université Paris Descartes, Sorbonne Paris Cité, Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="aff16"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Investigators, Kconfab" sort="Investigators, Kconfab" uniqKey="Investigators K" first="Kconfab" last="Investigators">Kconfab Investigators</name><affiliation><nlm:aff id="aff17"><addr-line>Kathleen Cuningham Consortium for Research into Familial Breast Cancer–Peter MacCallum Cancer Center, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="aff18"><addr-line>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff19"><addr-line>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita Katharina" sort="Schmutzler, Rita Katharina" uniqKey="Schmutzler R" first="Rita Katharina" last="Schmutzler">Rita Katharina Schmutzler</name><affiliation><nlm:aff id="aff20"><addr-line>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M." last="Domchek">Susan M. Domchek</name><affiliation><nlm:aff id="aff22"><addr-line>Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Piedmonte, Marion" sort="Piedmonte, Marion" uniqKey="Piedmonte M" first="Marion" last="Piedmonte">Marion Piedmonte</name><affiliation><nlm:aff id="aff23"><addr-line>Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, New York, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Singer, Christian F" sort="Singer, Christian F" uniqKey="Singer C" first="Christian F." last="Singer">Christian F. Singer</name><affiliation><nlm:aff id="aff24"><addr-line>Department of Obstetrics and Gynecology, and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</addr-line></nlm:aff></affiliation></author><author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><affiliation><nlm:aff id="aff25"><addr-line>Sheba Medical Center, Tel Aviv, Israel</addr-line></nlm:aff></affiliation></author><author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name><affiliation><nlm:aff id="aff26"><addr-line>Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V. O." last="Hansen">Thomas V. O. Hansen</name><affiliation><nlm:aff id="aff28"><addr-line>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="aff29"><addr-line>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I." last="Szabo">Csilla I. Szabo</name><affiliation><nlm:aff id="aff30"><addr-line>Center for Translational Cancer Research, Department of Biological Sciences, University of Delaware, Newark, Delaware, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Blanco, Ignacio" sort="Blanco, Ignacio" uniqKey="Blanco I" first="Ignacio" last="Blanco">Ignacio Blanco</name><affiliation><nlm:aff id="aff31"><addr-line>Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL–Catalan Institute of Oncology, Barcelona, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><affiliation><nlm:aff id="aff32"><addr-line>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y." last="Karlan">Beth Y. Karlan</name><affiliation><nlm:aff id="aff33"><addr-line>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Garber, Judy" sort="Garber, Judy" uniqKey="Garber J" first="Judy" last="Garber">Judy Garber</name><affiliation><nlm:aff id="aff34"><addr-line>Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Phelan, Catherine M" sort="Phelan, Catherine M" uniqKey="Phelan C" first="Catherine M." last="Phelan">Catherine M. Phelan</name><affiliation><nlm:aff id="aff35"><addr-line>Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Weitzel, Jeffrey N" sort="Weitzel, Jeffrey N" uniqKey="Weitzel J" first="Jeffrey N." last="Weitzel">Jeffrey N. Weitzel</name><affiliation><nlm:aff id="aff36"><addr-line>Clinical Cancer Genetics (for the City of Hope Clinical Cancer Genetics Community Research Network), City of Hope, Duarte, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name><affiliation><nlm:aff id="aff37"><addr-line>Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV–IRCCS, Padua, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name><affiliation><nlm:aff id="aff38"><addr-line>Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary</addr-line></nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="aff39"><addr-line>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name><affiliation><nlm:aff id="aff40"><addr-line>Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name><affiliation><nlm:aff id="aff41"><addr-line>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research Demokritos, Aghia Paraskevi Attikis, Athens, Greece</addr-line></nlm:aff></affiliation></author><author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E." last="Goldgar">David E. Goldgar</name><affiliation><nlm:aff id="aff42"><addr-line>Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name><affiliation><nlm:aff id="aff43"><addr-line>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="aff44"><addr-line>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name><affiliation><nlm:aff id="aff45"><addr-line>Human Genetics Group, Spanish National Cancer Centre (CNIO), and Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Terry, Mary Beth" sort="Terry, Mary Beth" uniqKey="Terry M" first="Mary Beth" last="Terry">Mary Beth Terry</name><affiliation><nlm:aff id="aff46"><addr-line>Department of Epidemiology, Columbia University, New York, New York, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B." last="Daly">Mary B. Daly</name><affiliation><nlm:aff id="aff47"><addr-line>Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Van Rensburg, Elizabeth J" sort="Van Rensburg, Elizabeth J" uniqKey="Van Rensburg E" first="Elizabeth J." last="Van Rensburg">Elizabeth J. Van Rensburg</name><affiliation><nlm:aff id="aff48"><addr-line>Department of Genetics, University of Pretoria, Pretoria, South Africa</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="aff49"><addr-line>Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ramus, Susan J" sort="Ramus, Susan J" uniqKey="Ramus S" first="Susan J." last="Ramus">Susan J. Ramus</name><affiliation><nlm:aff id="aff50"><addr-line>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ewart Toland, Amanda" sort="Ewart Toland, Amanda" uniqKey="Ewart Toland A" first="Amanda" last="Ewart Toland">Amanda Ewart Toland</name><affiliation><nlm:aff id="aff51"><addr-line>Divison of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A." last="Caligo">Maria A. Caligo</name><affiliation><nlm:aff id="aff52"><addr-line>Section of Genetic Oncology, Department of Laboratory Medicine, University of Pisa and University Hospital of Pisa, Pisa, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I." last="Olopade">Olufunmilayo I. Olopade</name><affiliation><nlm:aff id="aff53"><addr-line>Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tung, Nadine" sort="Tung, Nadine" uniqKey="Tung N" first="Nadine" last="Tung">Nadine Tung</name><affiliation><nlm:aff id="aff54"><addr-line>Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Claes, Kathleen" sort="Claes, Kathleen" uniqKey="Claes K" first="Kathleen" last="Claes">Kathleen Claes</name><affiliation><nlm:aff id="aff55"><addr-line>Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium</addr-line></nlm:aff></affiliation></author><author><name sortKey="Beattie, Mary S" sort="Beattie, Mary S" uniqKey="Beattie M" first="Mary S." last="Beattie">Mary S. Beattie</name><affiliation><nlm:aff id="aff56"><addr-line>Departments of Medicine, Epidemiology, and Biostatistics, University of California San Francisco, San Francisco, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="aff57"><addr-line>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Imyanitov, Evgeny N" sort="Imyanitov, Evgeny N" uniqKey="Imyanitov E" first="Evgeny N." last="Imyanitov">Evgeny N. Imyanitov</name><affiliation><nlm:aff id="aff58"><addr-line>N. N. Petrov Institute of Oncology, St. Petersburg, Russia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tischkowitz, Marc" sort="Tischkowitz, Marc" uniqKey="Tischkowitz M" first="Marc" last="Tischkowitz">Marc Tischkowitz</name><affiliation><nlm:aff id="aff59"><addr-line>Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Janavicius, Ramunas" sort="Janavicius, Ramunas" uniqKey="Janavicius R" first="Ramunas" last="Janavicius">Ramunas Janavicius</name><affiliation><nlm:aff id="aff60"><addr-line>Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius, Lithuania</addr-line></nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name><affiliation><nlm:aff id="aff61"><addr-line>Department of Epidemiology, Cancer Prevention Institute of California, Fremont, Califoria, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kwong, Ava" sort="Kwong, Ava" uniqKey="Kwong A" first="Ava" last="Kwong">Ava Kwong</name><affiliation><nlm:aff id="aff62"><addr-line>The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong, China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Diez, Orland" sort="Diez, Orland" uniqKey="Diez O" first="Orland" last="Diez">Orland Diez</name><affiliation><nlm:aff id="aff63"><addr-line>Oncogenetics Laboratory, University Hospital Vall d'Hebron and Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Balma A, Judith" sort="Balma A, Judith" uniqKey="Balma A J" first="Judith" last="Balma A">Judith Balma A</name><affiliation><nlm:aff id="aff64"><addr-line>Department of Medical Oncology, University Hospital, Vall d'Hebron, Barcelona, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Barkardottir, Rosa B" sort="Barkardottir, Rosa B" uniqKey="Barkardottir R" first="Rosa B." last="Barkardottir">Rosa B. Barkardottir</name><affiliation><nlm:aff id="aff65"><addr-line>Department of Pathology, Landspitali University Hospital and BMC, Faculty of Medicine, University of Iceland, Reykjavik, Iceland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Arun, Banu K" sort="Arun, Banu K" uniqKey="Arun B" first="Banu K." last="Arun">Banu K. Arun</name><affiliation><nlm:aff id="aff66"><addr-line>Department of Breast Medical Oncology and Clinical Cancer Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation><nlm:aff id="aff67"><addr-line>Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Haifa, Israel</addr-line></nlm:aff></affiliation></author><author><name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo-Hwang" last="Teo">Soo-Hwang Teo</name><affiliation><nlm:aff id="aff68"><addr-line>Cancer Research Initiatives Foundation, Sime Darby Medical Centre and University Malaya Cancer Research Institute, University of Malaya, Kuala Lumpur, Malaysia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name><affiliation><nlm:aff id="aff69"><addr-line>UCLA Schools of Medicine and Public Health, Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, Los Angeles, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Campbell, Ian" sort="Campbell, Ian" uniqKey="Campbell I" first="Ian" last="Campbell">Ian Campbell</name><affiliation><nlm:aff id="aff70"><addr-line>VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Van Der Hout, Annemarie H" sort="Van Der Hout, Annemarie H" uniqKey="Van Der Hout A" first="Annemarie H." last="Van Der Hout">Annemarie H. Van Der Hout</name><affiliation><nlm:aff id="aff71"><addr-line>Department of Genetics, University Medical Center, Groningen University, Groningen, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Van Deurzen, Carolien H M" sort="Van Deurzen, Carolien H M" uniqKey="Van Deurzen C" first="Carolien H. M." last="Van Deurzen">Carolien H. M. Van Deurzen</name><affiliation><nlm:aff id="aff72"><addr-line>Department of Pathology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation><nlm:aff id="aff73"><addr-line>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="G Mez Garcia, Encarna B" sort="G Mez Garcia, Encarna B" uniqKey="G Mez Garcia E" first="Encarna B." last="G Mez Garcia">Encarna B. G Mez Garcia</name><affiliation><nlm:aff id="aff74"><addr-line>Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, MUMC, Maastricht, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Van Leeuwen, Flora E" sort="Van Leeuwen, Flora E" uniqKey="Van Leeuwen F" first="Flora E." last="Van Leeuwen">Flora E. Van Leeuwen</name><affiliation><nlm:aff id="aff75"><addr-line>Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Meijers Heijboer, Hanne E J" sort="Meijers Heijboer, Hanne E J" uniqKey="Meijers Heijboer H" first="Hanne E. J." last="Meijers-Heijboer">Hanne E. J. Meijers-Heijboer</name><affiliation><nlm:aff id="aff76"><addr-line>Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gille, Johannes J P" sort="Gille, Johannes J P" uniqKey="Gille J" first="Johannes J. P." last="Gille">Johannes J. P. Gille</name><affiliation><nlm:aff id="aff76"><addr-line>Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ausems, Margreet G E M" sort="Ausems, Margreet G E M" uniqKey="Ausems M" first="Margreet G. E. M." last="Ausems">Margreet G. E. M. Ausems</name><affiliation><nlm:aff id="aff77"><addr-line>Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Blok, Marinus J" sort="Blok, Marinus J" uniqKey="Blok M" first="Marinus J." last="Blok">Marinus J. Blok</name><affiliation><nlm:aff id="aff78"><addr-line>Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ligtenberg, Marjolijn J L" sort="Ligtenberg, Marjolijn J L" uniqKey="Ligtenberg M" first="Marjolijn J. L." last="Ligtenberg">Marjolijn J. L. Ligtenberg</name><affiliation><nlm:aff id="aff79"><addr-line>Department of Human Genetics and Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rookus, Matti A" sort="Rookus, Matti A" uniqKey="Rookus M" first="Matti A." last="Rookus">Matti A. Rookus</name><affiliation><nlm:aff id="aff75"><addr-line>Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="aff80"><addr-line>Department of Human Genetics and Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Verhoef, Senno" sort="Verhoef, Senno" uniqKey="Verhoef S" first="Senno" last="Verhoef">Senno Verhoef</name><affiliation><nlm:aff id="aff12"><addr-line>Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Van Os, Theo A M" sort="Van Os, Theo A M" uniqKey="Van Os T" first="Theo A. M." last="Van Os">Theo A. M. Van Os</name><affiliation><nlm:aff id="aff81"><addr-line>Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wijnen, Juul T" sort="Wijnen, Juul T" uniqKey="Wijnen J" first="Juul T." last="Wijnen">Juul T. Wijnen</name><affiliation><nlm:aff id="aff82"><addr-line>Department of Human Genetics and Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ellis, Steve" sort="Ellis, Steve" uniqKey="Ellis S" first="Steve" last="Ellis">Steve Ellis</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fineberg, Elena" sort="Fineberg, Elena" uniqKey="Fineberg E" first="Elena" last="Fineberg">Elena Fineberg</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Platte, Radka" sort="Platte, Radka" uniqKey="Platte R" first="Radka" last="Platte">Radka Platte</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D. Gareth" last="Evans">D. Gareth Evans</name><affiliation><nlm:aff id="aff84"><addr-line>Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Izatt, Louise" sort="Izatt, Louise" uniqKey="Izatt L" first="Louise" last="Izatt">Louise Izatt</name><affiliation><nlm:aff id="aff85"><addr-line>Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name><affiliation><nlm:aff id="aff86"><addr-line>Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Adlard, Julian" sort="Adlard, Julian" uniqKey="Adlard J" first="Julian" last="Adlard">Julian Adlard</name><affiliation><nlm:aff id="aff87"><addr-line>Yorkshire Regional Genetics Service, Leeds, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Eccles, Diana M" sort="Eccles, Diana M" uniqKey="Eccles D" first="Diana M." last="Eccles">Diana M. Eccles</name><affiliation><nlm:aff id="aff88"><addr-line>University of Southampton Faculty of Medicine, Southampton University Hospitals NHS Trust, Southampton, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cook, Jackie" sort="Cook, Jackie" uniqKey="Cook J" first="Jackie" last="Cook">Jackie Cook</name><affiliation><nlm:aff id="aff89"><addr-line>Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Brewer, Carole" sort="Brewer, Carole" uniqKey="Brewer C" first="Carole" last="Brewer">Carole Brewer</name><affiliation><nlm:aff id="aff90"><addr-line>Department of Clinical Genetics, Royal Devon and Exeter Hospital, Exeter, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Douglas, Fiona" sort="Douglas, Fiona" uniqKey="Douglas F" first="Fiona" last="Douglas">Fiona Douglas</name><affiliation><nlm:aff id="aff91"><addr-line>Institute of Genetic Medicine, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hodgson, Shirley" sort="Hodgson, Shirley" uniqKey="Hodgson S" first="Shirley" last="Hodgson">Shirley Hodgson</name><affiliation><nlm:aff id="aff92"><addr-line>Department of Clinical Genetics, St George's University of London, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Morrison, Patrick J" sort="Morrison, Patrick J" uniqKey="Morrison P" first="Patrick J." last="Morrison">Patrick J. Morrison</name><affiliation><nlm:aff id="aff93"><addr-line>Northern Ireland Regional Genetics Centre, Belfast Health and Social Care Trust, and Department of Medical Genetics, Queens University Belfast, Belfast, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Side, Lucy E" sort="Side, Lucy E" uniqKey="Side L" first="Lucy E." last="Side">Lucy E. Side</name><affiliation><nlm:aff id="aff94"><addr-line>North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust and Institute for Womens Health, University College London, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Donaldson, Alan" sort="Donaldson, Alan" uniqKey="Donaldson A" first="Alan" last="Donaldson">Alan Donaldson</name><affiliation><nlm:aff id="aff95"><addr-line>Clinical Genetics Department, St Michael's Hospital, Bristol, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Houghton, Catherine" sort="Houghton, Catherine" uniqKey="Houghton C" first="Catherine" last="Houghton">Catherine Houghton</name><affiliation><nlm:aff id="aff96"><addr-line>Cheshire and Merseyside Clinical Genetics Service, Liverpool Women's NHS Foundation Trust, Liverpool, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rogers, Mark T" sort="Rogers, Mark T" uniqKey="Rogers M" first="Mark T." last="Rogers">Mark T. Rogers</name><affiliation><nlm:aff id="aff97"><addr-line>All Wales Medical Genetics Services, University Hospital of Wales, Cardiff, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dorkins, Huw" sort="Dorkins, Huw" uniqKey="Dorkins H" first="Huw" last="Dorkins">Huw Dorkins</name><affiliation><nlm:aff id="aff98"><addr-line>North West Thames Regional Genetics Service, Kennedy-Galton Centre, Harrow, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Eason, Jacqueline" sort="Eason, Jacqueline" uniqKey="Eason J" first="Jacqueline" last="Eason">Jacqueline Eason</name><affiliation><nlm:aff id="aff99"><addr-line>Nottingham Clinical Genetics Service, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gregory, Helen" sort="Gregory, Helen" uniqKey="Gregory H" first="Helen" last="Gregory">Helen Gregory</name><affiliation><nlm:aff id="aff100"><addr-line>North of Scotland Regional Genetics Service, NHS Grampian and University of Aberdeen, Foresterhill, Aberdeen, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mccann, Emma" sort="Mccann, Emma" uniqKey="Mccann E" first="Emma" last="Mccann">Emma Mccann</name><affiliation><nlm:aff id="aff101"><addr-line>All Wales Medical Genetics Services, Glan Clwyd Hospital, Rhyl, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Murray, Alex" sort="Murray, Alex" uniqKey="Murray A" first="Alex" last="Murray">Alex Murray</name><affiliation><nlm:aff id="aff102"><addr-line>All Wales Medical Genetics Services, Singleton Hospital, Swansea, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Calender, Alain" sort="Calender, Alain" uniqKey="Calender A" first="Alain" last="Calender">Alain Calender</name><affiliation><nlm:aff id="aff8"><addr-line>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon–Centre Léon Bérard, Lyon, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hardouin, Agnes" sort="Hardouin, Agnes" uniqKey="Hardouin A" first="Agnès" last="Hardouin">Agnès Hardouin</name><affiliation><nlm:aff id="aff103"><addr-line>Centre François Baclesse, Caen, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Berthet, Pascaline" sort="Berthet, Pascaline" uniqKey="Berthet P" first="Pascaline" last="Berthet">Pascaline Berthet</name><affiliation><nlm:aff id="aff103"><addr-line>Centre François Baclesse, Caen, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Delnatte, Capucine" sort="Delnatte, Capucine" uniqKey="Delnatte C" first="Capucine" last="Delnatte">Capucine Delnatte</name><affiliation><nlm:aff id="aff104"><addr-line>Centre René Gauducheau, Nantes, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nogues, Catherine" sort="Nogues, Catherine" uniqKey="Nogues C" first="Catherine" last="Nogues">Catherine Nogues</name><affiliation><nlm:aff id="aff105"><addr-line>Oncogénétique Clinique, Hôpital René Huguenin/Institut Curie, Saint-Cloud, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lasset, Christine" sort="Lasset, Christine" uniqKey="Lasset C" first="Christine" last="Lasset">Christine Lasset</name><affiliation><nlm:aff id="aff106"><addr-line>Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff107"><addr-line>Université Lyon 1, CNRS UMR5558, Lyon, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Houdayer, Claude" sort="Houdayer, Claude" uniqKey="Houdayer C" first="Claude" last="Houdayer">Claude Houdayer</name><affiliation><nlm:aff id="aff13"><addr-line>Institut Curie, Department of Tumour Biology, Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff15"><addr-line>Université Paris Descartes, Sorbonne Paris Cité, Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Leroux, Dominique" sort="Leroux, Dominique" uniqKey="Leroux D" first="Dominique" last="Leroux">Dominique Leroux</name><affiliation><nlm:aff id="aff108"><addr-line>Department of Genetics, Centre Hospitalier Universitaire de Grenoble, Grenoble, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff109"><addr-line>Institut Albert Bonniot, Université de Grenoble, Grenoble, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rouleau, Etienne" sort="Rouleau, Etienne" uniqKey="Rouleau E" first="Etienne" last="Rouleau">Etienne Rouleau</name><affiliation><nlm:aff id="aff110"><addr-line>Laboratoire d'Oncogénétique, Hôpital René Huguenin, Institut Curie, Saint-Cloud, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Prieur, Fabienne" sort="Prieur, Fabienne" uniqKey="Prieur F" first="Fabienne" last="Prieur">Fabienne Prieur</name><affiliation><nlm:aff id="aff111"><addr-line>Service de Génétique Clinique Chromosomique et Moléculaire, Centre Hospitalier Universitaire de St Etienne, St Etienne, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Damiola, Francesca" sort="Damiola, Francesca" uniqKey="Damiola F" first="Francesca" last="Damiola">Francesca Damiola</name><affiliation><nlm:aff id="aff9"><addr-line>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sobol, Hagay" sort="Sobol, Hagay" uniqKey="Sobol H" first="Hagay" last="Sobol">Hagay Sobol</name><affiliation><nlm:aff id="aff112"><addr-line>Département Oncologie Génétique, Prévention et Dépistage, INSERM CIC-P9502, Institut Paoli-Calmettes/Université d'Aix-Marseille II, Marseille, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Coupier, Isabelle" sort="Coupier, Isabelle" uniqKey="Coupier I" first="Isabelle" last="Coupier">Isabelle Coupier</name><affiliation><nlm:aff id="aff113"><addr-line>Unité d'Oncogénétique, CHU Arnaud de Villeneuve, Montpellier, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff114"><addr-line>Unité d'Oncogénétique, CRLCC Val d'Aurelle, Montpellier, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Venat Bouvet, Laurence" sort="Venat Bouvet, Laurence" uniqKey="Venat Bouvet L" first="Laurence" last="Venat-Bouvet">Laurence Venat-Bouvet</name><affiliation><nlm:aff id="aff115"><addr-line>Department of Medical Oncology, Centre Hospitalier Universitaire Dupuytren, Limoges, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Castera, Laurent" sort="Castera, Laurent" uniqKey="Castera L" first="Laurent" last="Castera">Laurent Castera</name><affiliation><nlm:aff id="aff13"><addr-line>Institut Curie, Department of Tumour Biology, Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gauthier Villars, Marion" sort="Gauthier Villars, Marion" uniqKey="Gauthier Villars M" first="Marion" last="Gauthier-Villars">Marion Gauthier-Villars</name><affiliation><nlm:aff id="aff13"><addr-line>Institut Curie, Department of Tumour Biology, Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Leone, Melanie" sort="Leone, Melanie" uniqKey="Leone M" first="Mélanie" last="Léoné">Mélanie Léoné</name><affiliation><nlm:aff id="aff8"><addr-line>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon–Centre Léon Bérard, Lyon, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pujol, Pascal" sort="Pujol, Pascal" uniqKey="Pujol P" first="Pascal" last="Pujol">Pascal Pujol</name><affiliation><nlm:aff id="aff113"><addr-line>Unité d'Oncogénétique, CHU Arnaud de Villeneuve, Montpellier, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff116"><addr-line>INSERM 896, CRCM Val d'Aurelle, Montpellier, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name><affiliation><nlm:aff id="aff9"><addr-line>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bignon, Yves Jean" sort="Bignon, Yves Jean" uniqKey="Bignon Y" first="Yves-Jean" last="Bignon">Yves-Jean Bignon</name><affiliation><nlm:aff id="aff117"><addr-line>Département d'Oncogénétique, Centre Jean Perrin, Université de Clermont-Ferrand, Clermont-Ferrand, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zlowocka Perlowska, El Bieta" sort="Zlowocka Perlowska, El Bieta" uniqKey="Zlowocka Perlowska E" first="El Bieta" last="Złowocka-Perłowska">El Bieta Złowocka-Perłowska</name><affiliation><nlm:aff id="aff16"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name><affiliation><nlm:aff id="aff16"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="aff16"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="aff16"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jaworska, Katarzyna" sort="Jaworska, Katarzyna" uniqKey="Jaworska K" first="Katarzyna" last="Jaworska">Katarzyna Jaworska</name><affiliation><nlm:aff id="aff16"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff119"><addr-line>Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Huzarski, Tomasz" sort="Huzarski, Tomasz" uniqKey="Huzarski T" first="Tomasz" last="Huzarski">Tomasz Huzarski</name><affiliation><nlm:aff id="aff16"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name><affiliation><nlm:aff id="aff7"><addr-line>Genetics Department, Queensland Institute of Medical Research, Brisbane, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Viel, Alessandra" sort="Viel, Alessandra" uniqKey="Viel A" first="Alessandra" last="Viel">Alessandra Viel</name><affiliation><nlm:aff id="aff120"><addr-line>Division of Experimental Oncology 1, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Peissel, Bernard" sort="Peissel, Bernard" uniqKey="Peissel B" first="Bernard" last="Peissel">Bernard Peissel</name><affiliation><nlm:aff id="aff121"><addr-line>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name><affiliation><nlm:aff id="aff122"><addr-line>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Melloni, Giulia" sort="Melloni, Giulia" uniqKey="Melloni G" first="Giulia" last="Melloni">Giulia Melloni</name><affiliation><nlm:aff id="aff121"><addr-line>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ottini, Laura" sort="Ottini, Laura" uniqKey="Ottini L" first="Laura" last="Ottini">Laura Ottini</name><affiliation><nlm:aff id="aff123"><addr-line>Department of Molecular Medicine, Sapienza University, Rome, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Papi, Laura" sort="Papi, Laura" uniqKey="Papi L" first="Laura" last="Papi">Laura Papi</name><affiliation><nlm:aff id="aff124"><addr-line>Unit of Medical Genetics, Department of Clinical Physiopathology, University of Florence, Firenze, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Varesco, Liliana" sort="Varesco, Liliana" uniqKey="Varesco L" first="Liliana" last="Varesco">Liliana Varesco</name><affiliation><nlm:aff id="aff125"><addr-line>Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, IRCCS AOU San Martino–IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tibiletti, Maria Grazia" sort="Tibiletti, Maria Grazia" uniqKey="Tibiletti M" first="Maria Grazia" last="Tibiletti">Maria Grazia Tibiletti</name><affiliation><nlm:aff id="aff126"><addr-line>UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria, Varese, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="aff18"><addr-line>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff19"><addr-line>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Volorio, Sara" sort="Volorio, Sara" uniqKey="Volorio S" first="Sara" last="Volorio">Sara Volorio</name><affiliation><nlm:aff id="aff127"><addr-line>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare and Cogentech Cancer Genetic Test Laboratory, Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="aff121"><addr-line>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pensotti, Valeria" sort="Pensotti, Valeria" uniqKey="Pensotti V" first="Valeria" last="Pensotti">Valeria Pensotti</name><affiliation><nlm:aff id="aff127"><addr-line>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare and Cogentech Cancer Genetic Test Laboratory, Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name><affiliation><nlm:aff id="aff128"><addr-line>University Hospital of Schleswig-Holstein/University Kiel, Kiel, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name><affiliation><nlm:aff id="aff129"><addr-line>Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Deissler, Helmut" sort="Deissler, Helmut" uniqKey="Deissler H" first="Helmut" last="Deissler">Helmut Deissler</name><affiliation><nlm:aff id="aff130"><addr-line>University Hospital Ulm, Ulm, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gadzicki, Dorothea" sort="Gadzicki, Dorothea" uniqKey="Gadzicki D" first="Dorothea" last="Gadzicki">Dorothea Gadzicki</name><affiliation><nlm:aff id="aff131"><addr-line>Hannover Medical School, Hanover, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gehrig, Andrea" sort="Gehrig, Andrea" uniqKey="Gehrig A" first="Andrea" last="Gehrig">Andrea Gehrig</name><affiliation><nlm:aff id="aff132"><addr-line>Institute of Human Genetics, University of Würzburg, Wurzburg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kast, Karin" sort="Kast, Karin" uniqKey="Kast K" first="Karin" last="Kast">Karin Kast</name><affiliation><nlm:aff id="aff133"><addr-line>Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rhiem, Kerstin" sort="Rhiem, Kerstin" uniqKey="Rhiem K" first="Kerstin" last="Rhiem">Kerstin Rhiem</name><affiliation><nlm:aff id="aff20"><addr-line>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="aff134"><addr-line>Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name><affiliation><nlm:aff id="aff135"><addr-line>Department of Obstetrics and Gynaecology, University Medical Center Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ditsch, Nina" sort="Ditsch, Nina" uniqKey="Ditsch N" first="Nina" last="Ditsch">Nina Ditsch</name><affiliation><nlm:aff id="aff136"><addr-line>Department of Gynaecology and Obstetrics, University of Munich, Munich, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Plendl, Hansjoerg" sort="Plendl, Hansjoerg" uniqKey="Plendl H" first="Hansjoerg" last="Plendl">Hansjoerg Plendl</name><affiliation><nlm:aff id="aff137"><addr-line>Institute of Human Genetics, University Hospital of Schleswig-Holstein, University of Kiel, Kiel, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Preisler Adams, Sabine" sort="Preisler Adams, Sabine" uniqKey="Preisler Adams S" first="Sabine" last="Preisler-Adams">Sabine Preisler-Adams</name><affiliation><nlm:aff id="aff138"><addr-line>Institute of Human Genetics, Münster, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Engert, Stefanie" sort="Engert, Stefanie" uniqKey="Engert S" first="Stefanie" last="Engert">Stefanie Engert</name><affiliation><nlm:aff id="aff134"><addr-line>Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name><affiliation><nlm:aff id="aff139"><addr-line>Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Varon Mateeva, Raymonda" sort="Varon Mateeva, Raymonda" uniqKey="Varon Mateeva R" first="Raymonda" last="Varon-Mateeva">Raymonda Varon-Mateeva</name><affiliation><nlm:aff id="aff140"><addr-line>Institute of Medical and Human Genetics, Berlin, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wappenschmidt, Barbara" sort="Wappenschmidt, Barbara" uniqKey="Wappenschmidt B" first="Barbara" last="Wappenschmidt">Barbara Wappenschmidt</name><affiliation><nlm:aff id="aff20"><addr-line>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Weber, Bernhard H F" sort="Weber, Bernhard H F" uniqKey="Weber B" first="Bernhard H. F." last="Weber">Bernhard H. F. Weber</name><affiliation><nlm:aff id="aff141"><addr-line>Institute of Human Genetics, University of Regensburg, Regensburg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Arver, Brita" sort="Arver, Brita" uniqKey="Arver B" first="Brita" last="Arver">Brita Arver</name><affiliation><nlm:aff id="aff142"><addr-line>Department of Oncology and Pathology, Karolinska University Hospital, Stockholm, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stenmark Askmalm, Marie" sort="Stenmark Askmalm, Marie" uniqKey="Stenmark Askmalm M" first="Marie" last="Stenmark-Askmalm">Marie Stenmark-Askmalm</name><affiliation><nlm:aff id="aff143"><addr-line>Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Loman, Niklas" sort="Loman, Niklas" uniqKey="Loman N" first="Niklas" last="Loman">Niklas Loman</name><affiliation><nlm:aff id="aff144"><addr-line>Department of Oncology, Lund University Hospital, Lund, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rosenquist, Richard" sort="Rosenquist, Richard" uniqKey="Rosenquist R" first="Richard" last="Rosenquist">Richard Rosenquist</name><affiliation><nlm:aff id="aff145"><addr-line>Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Einbeigi, Zakaria" sort="Einbeigi, Zakaria" uniqKey="Einbeigi Z" first="Zakaria" last="Einbeigi">Zakaria Einbeigi</name><affiliation><nlm:aff id="aff146"><addr-line>Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><affiliation><nlm:aff id="aff147"><addr-line>Abramson Cancer Center and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rebbeck, Timothy R" sort="Rebbeck, Timothy R" uniqKey="Rebbeck T" first="Timothy R." last="Rebbeck">Timothy R. Rebbeck</name><affiliation><nlm:aff id="aff148"><addr-line>Abramson Cancer Center and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Blank, Stephanie V" sort="Blank, Stephanie V" uniqKey="Blank S" first="Stephanie V." last="Blank">Stephanie V. Blank</name><affiliation><nlm:aff id="aff149"><addr-line>NYU Women's Cancer Program, New York University School of Medicine, New York, New York, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cohn, David E" sort="Cohn, David E" uniqKey="Cohn D" first="David E." last="Cohn">David E. Cohn</name><affiliation><nlm:aff id="aff150"><addr-line>Ohio State University, Columbus Cancer Council, Columbus, Ohio, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rodriguez, Gustavo C" sort="Rodriguez, Gustavo C" uniqKey="Rodriguez G" first="Gustavo C." last="Rodriguez">Gustavo C. Rodriguez</name><affiliation><nlm:aff id="aff151"><addr-line>Division of Gynecologic Oncology, North Shore University Health System, University of Chicago, Evanston, Illinois, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Small, Laurie" sort="Small, Laurie" uniqKey="Small L" first="Laurie" last="Small">Laurie Small</name><affiliation><nlm:aff id="aff152"><addr-line>Maine Medical Center, Maine Women's Surgery and Cancer Centre, Scarborough, Maine, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Friedlander, Michael" sort="Friedlander, Michael" uniqKey="Friedlander M" first="Michael" last="Friedlander">Michael Friedlander</name><affiliation><nlm:aff id="aff153"><addr-line>ANZ GOTG Coordinating Centre, Australia New Zealand GOG, Camperdown, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bae Jump, Victoria L" sort="Bae Jump, Victoria L" uniqKey="Bae Jump V" first="Victoria L." last="Bae-Jump">Victoria L. Bae-Jump</name><affiliation><nlm:aff id="aff154"><addr-line>The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fink Retter, Anneliese" sort="Fink Retter, Anneliese" uniqKey="Fink Retter A" first="Anneliese" last="Fink-Retter">Anneliese Fink-Retter</name><affiliation><nlm:aff id="aff24"><addr-line>Department of Obstetrics and Gynecology, and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rappaport, Christine" sort="Rappaport, Christine" uniqKey="Rappaport C" first="Christine" last="Rappaport">Christine Rappaport</name><affiliation><nlm:aff id="aff24"><addr-line>Department of Obstetrics and Gynecology, and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gschwantler Kaulich, Daphne" sort="Gschwantler Kaulich, Daphne" uniqKey="Gschwantler Kaulich D" first="Daphne" last="Gschwantler-Kaulich">Daphne Gschwantler-Kaulich</name><affiliation><nlm:aff id="aff24"><addr-line>Department of Obstetrics and Gynecology, and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pfeiler, Georg" sort="Pfeiler, Georg" uniqKey="Pfeiler G" first="Georg" last="Pfeiler">Georg Pfeiler</name><affiliation><nlm:aff id="aff24"><addr-line>Department of Obstetrics and Gynecology, and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tea, Muy Kheng" sort="Tea, Muy Kheng" uniqKey="Tea M" first="Muy-Kheng" last="Tea">Muy-Kheng Tea</name><affiliation><nlm:aff id="aff24"><addr-line>Department of Obstetrics and Gynecology, and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M." last="Lindor">Noralane M. Lindor</name><affiliation><nlm:aff id="aff155"><addr-line>Department of Health Science Research, Mayo Clinic Arizona, Scottsdale, Arizona, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kaufman, Bella" sort="Kaufman, Bella" uniqKey="Kaufman B" first="Bella" last="Kaufman">Bella Kaufman</name><affiliation><nlm:aff id="aff25"><addr-line>Sheba Medical Center, Tel Aviv, Israel</addr-line></nlm:aff></affiliation></author><author><name sortKey="Shimon Paluch, Shani" sort="Shimon Paluch, Shani" uniqKey="Shimon Paluch S" first="Shani" last="Shimon Paluch">Shani Shimon Paluch</name><affiliation><nlm:aff id="aff25"><addr-line>Sheba Medical Center, Tel Aviv, Israel</addr-line></nlm:aff></affiliation></author><author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name><affiliation><nlm:aff id="aff25"><addr-line>Sheba Medical Center, Tel Aviv, Israel</addr-line></nlm:aff></affiliation></author><author><name sortKey="Skytte, Anne Bine" sort="Skytte, Anne Bine" uniqKey="Skytte A" first="Anne-Bine" last="Skytte">Anne-Bine Skytte</name><affiliation><nlm:aff id="aff156"><addr-line>Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gerdes, Anne Marie" sort="Gerdes, Anne Marie" uniqKey="Gerdes A" first="Anne-Marie" last="Gerdes">Anne-Marie Gerdes</name><affiliation><nlm:aff id="aff157"><addr-line>Department of Clincial Genetics, Rigshospitalet, København, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pedersen, Inge Sokilde" sort="Pedersen, Inge Sokilde" uniqKey="Pedersen I" first="Inge Sokilde" last="Pedersen">Inge Sokilde Pedersen</name><affiliation><nlm:aff id="aff158"><addr-line>Section of Molecular Diagnostics, Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Moeller, Sanne Traasdahl" sort="Moeller, Sanne Traasdahl" uniqKey="Moeller S" first="Sanne Traasdahl" last="Moeller">Sanne Traasdahl Moeller</name><affiliation><nlm:aff id="aff26"><addr-line>Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kruse, Torben A" sort="Kruse, Torben A" uniqKey="Kruse T" first="Torben A." last="Kruse">Torben A. Kruse</name><affiliation><nlm:aff id="aff26"><addr-line>Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jensen, Uffe Birk" sort="Jensen, Uffe Birk" uniqKey="Jensen U" first="Uffe Birk" last="Jensen">Uffe Birk Jensen</name><affiliation><nlm:aff id="aff159"><addr-line>Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name><affiliation><nlm:aff id="aff160"><addr-line>Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sarrel, Kara" sort="Sarrel, Kara" uniqKey="Sarrel K" first="Kara" last="Sarrel">Kara Sarrel</name><affiliation><nlm:aff id="aff160"><addr-line>Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Robson, Mark" sort="Robson, Mark" uniqKey="Robson M" first="Mark" last="Robson">Mark Robson</name><affiliation><nlm:aff id="aff160"><addr-line>Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kauff, Noah" sort="Kauff, Noah" uniqKey="Kauff N" first="Noah" last="Kauff">Noah Kauff</name><affiliation><nlm:aff id="aff160"><addr-line>Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="aff161"><addr-line>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff162"><addr-line>Department of Laboratory Medicine, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="aff27"><addr-line>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ozcelik, Hilmi" sort="Ozcelik, Hilmi" uniqKey="Ozcelik H" first="Hilmi" last="Ozcelik">Hilmi Ozcelik</name><affiliation><nlm:aff id="aff39"><addr-line>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff161"><addr-line>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ejlertsen, Bent" sort="Ejlertsen, Bent" uniqKey="Ejlertsen B" first="Bent" last="Ejlertsen">Bent Ejlertsen</name><affiliation><nlm:aff id="aff163"><addr-line>Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nielsen, Finn C" sort="Nielsen, Finn C" uniqKey="Nielsen F" first="Finn C." last="Nielsen">Finn C. Nielsen</name><affiliation><nlm:aff id="aff28"><addr-line>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="J Nson, Lars" sort="J Nson, Lars" uniqKey="J Nson L" first="Lars" last="J Nson">Lars J Nson</name><affiliation><nlm:aff id="aff28"><addr-line>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Andersen, Mette K" sort="Andersen, Mette K" uniqKey="Andersen M" first="Mette K." last="Andersen">Mette K. Andersen</name><affiliation><nlm:aff id="aff164"><addr-line>Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ding, Yuan Chun" sort="Ding, Yuan Chun" uniqKey="Ding Y" first="Yuan Chun" last="Ding">Yuan Chun Ding</name><affiliation><nlm:aff id="aff29"><addr-line>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Steele, Linda" sort="Steele, Linda" uniqKey="Steele L" first="Linda" last="Steele">Linda Steele</name><affiliation><nlm:aff id="aff29"><addr-line>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name><affiliation><nlm:aff id="aff165"><addr-line>Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic</addr-line></nlm:aff></affiliation></author><author><name sortKey="Teule, Alex" sort="Teule, Alex" uniqKey="Teule A" first="Alex" last="Teulé">Alex Teulé</name><affiliation><nlm:aff id="aff31"><addr-line>Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL–Catalan Institute of Oncology, Barcelona, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lazaro, Conxi" sort="Lazaro, Conxi" uniqKey="Lazaro C" first="Conxi" last="Lazaro">Conxi Lazaro</name><affiliation><nlm:aff id="aff166"><addr-line>Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL–Catalan Institute of Oncology, Barcelona, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Brunet, Joan" sort="Brunet, Joan" uniqKey="Brunet J" first="Joan" last="Brunet">Joan Brunet</name><affiliation><nlm:aff id="aff167"><addr-line>Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI–Catalan Institute of Oncology, Girona, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pujana, Miquel Angel" sort="Pujana, Miquel Angel" uniqKey="Pujana M" first="Miquel Angel" last="Pujana">Miquel Angel Pujana</name><affiliation><nlm:aff id="aff168"><addr-line>Translational Research Laboratory, Breast Cancer and Systems Biology Unit, IDIBELL–Catalan Institute of Oncology, Barcelona, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L." last="Mai">Phuong L. Mai</name><affiliation><nlm:aff id="aff32"><addr-line>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Loud, Jennifer T" sort="Loud, Jennifer T" uniqKey="Loud J" first="Jennifer T." last="Loud">Jennifer T. Loud</name><affiliation><nlm:aff id="aff32"><addr-line>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Walsh, Christine" sort="Walsh, Christine" uniqKey="Walsh C" first="Christine" last="Walsh">Christine Walsh</name><affiliation><nlm:aff id="aff33"><addr-line>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lester, Jenny" sort="Lester, Jenny" uniqKey="Lester J" first="Jenny" last="Lester">Jenny Lester</name><affiliation><nlm:aff id="aff33"><addr-line>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Orsulic, Sandra" sort="Orsulic, Sandra" uniqKey="Orsulic S" first="Sandra" last="Orsulic">Sandra Orsulic</name><affiliation><nlm:aff id="aff33"><addr-line>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Narod, Steven A" sort="Narod, Steven A" uniqKey="Narod S" first="Steven A." last="Narod">Steven A. Narod</name><affiliation><nlm:aff id="aff169"><addr-line>Women's College Research Institute, University of Toronto, Toronto, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Herzog, Josef" sort="Herzog, Josef" uniqKey="Herzog J" first="Josef" last="Herzog">Josef Herzog</name><affiliation><nlm:aff id="aff36"><addr-line>Clinical Cancer Genetics (for the City of Hope Clinical Cancer Genetics Community Research Network), City of Hope, Duarte, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sand, Sharon R" sort="Sand, Sharon R" uniqKey="Sand S" first="Sharon R." last="Sand">Sharon R. Sand</name><affiliation><nlm:aff id="aff36"><addr-line>Clinical Cancer Genetics (for the City of Hope Clinical Cancer Genetics Community Research Network), City of Hope, Duarte, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tognazzo, Silvia" sort="Tognazzo, Silvia" uniqKey="Tognazzo S" first="Silvia" last="Tognazzo">Silvia Tognazzo</name><affiliation><nlm:aff id="aff37"><addr-line>Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV–IRCCS, Padua, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Agata, Simona" sort="Agata, Simona" uniqKey="Agata S" first="Simona" last="Agata">Simona Agata</name><affiliation><nlm:aff id="aff37"><addr-line>Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV–IRCCS, Padua, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vaszko, Tibor" sort="Vaszko, Tibor" uniqKey="Vaszko T" first="Tibor" last="Vaszko">Tibor Vaszko</name><affiliation><nlm:aff id="aff38"><addr-line>Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary</addr-line></nlm:aff></affiliation></author><author><name sortKey="Weaver, Joellen" sort="Weaver, Joellen" uniqKey="Weaver J" first="Joellen" last="Weaver">Joellen Weaver</name><affiliation><nlm:aff id="aff170"><addr-line>Biosample Repository, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stavropoulou, Alexandra V" sort="Stavropoulou, Alexandra V" uniqKey="Stavropoulou A" first="Alexandra V." last="Stavropoulou">Alexandra V. Stavropoulou</name><affiliation><nlm:aff id="aff41"><addr-line>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research Demokritos, Aghia Paraskevi Attikis, Athens, Greece</addr-line></nlm:aff></affiliation></author><author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S." last="Buys">Saundra S. Buys</name><affiliation><nlm:aff id="aff171"><addr-line>Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Romero, Atocha" sort="Romero, Atocha" uniqKey="Romero A" first="Atocha" last="Romero">Atocha Romero</name><affiliation><nlm:aff id="aff43"><addr-line>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="De La Hoya, Miguel" sort="De La Hoya, Miguel" uniqKey="De La Hoya M" first="Miguel" last="De La Hoya">Miguel De La Hoya</name><affiliation><nlm:aff id="aff43"><addr-line>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="aff172"><addr-line>Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name><affiliation><nlm:aff id="aff44"><addr-line>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Duran, Mercedes" sort="Duran, Mercedes" uniqKey="Duran M" first="Mercedes" last="Duran">Mercedes Duran</name><affiliation><nlm:aff id="aff173"><addr-line>Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM–UVA), Valladolid, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chung, Wendy K" sort="Chung, Wendy K" uniqKey="Chung W" first="Wendy K." last="Chung">Wendy K. Chung</name><affiliation><nlm:aff id="aff174"><addr-line>Departments of Pediatrics and Medicine, Columbia University, New York, New York, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lasa, Adriana" sort="Lasa, Adriana" uniqKey="Lasa A" first="Adriana" last="Lasa">Adriana Lasa</name><affiliation><nlm:aff id="aff175"><addr-line>Genetics Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dorfling, Cecilia M" sort="Dorfling, Cecilia M" uniqKey="Dorfling C" first="Cecilia M." last="Dorfling">Cecilia M. Dorfling</name><affiliation><nlm:aff id="aff48"><addr-line>Department of Genetics, University of Pretoria, Pretoria, South Africa</addr-line></nlm:aff></affiliation></author><author><name sortKey="Miron, Alexander" sort="Miron, Alexander" uniqKey="Miron A" first="Alexander" last="Miron">Alexander Miron</name><affiliation><nlm:aff id="aff176"><addr-line>Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="aff178"><addr-line>Human Genetics Group and Genotyping Unit, Spanish National Cancer Centre (CNIO), and Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Senter, Leigha" sort="Senter, Leigha" uniqKey="Senter L" first="Leigha" last="Senter">Leigha Senter</name><affiliation><nlm:aff id="aff179"><addr-line>Divison of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Huo, Dezheng" sort="Huo, Dezheng" uniqKey="Huo D" first="Dezheng" last="Huo">Dezheng Huo</name><affiliation><nlm:aff id="aff53"><addr-line>Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chan, Salina B" sort="Chan, Salina B" uniqKey="Chan S" first="Salina B." last="Chan">Salina B. Chan</name><affiliation><nlm:aff id="aff180"><addr-line>Cancer Risk Program, Helen Diller Family Cancer Center, University of California San Francisco, San Francisco, California, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sokolenko, Anna P" sort="Sokolenko, Anna P" uniqKey="Sokolenko A" first="Anna P." last="Sokolenko">Anna P. Sokolenko</name><affiliation><nlm:aff id="aff58"><addr-line>N. N. Petrov Institute of Oncology, St. Petersburg, Russia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chiquette, Jocelyne" sort="Chiquette, Jocelyne" uniqKey="Chiquette J" first="Jocelyne" last="Chiquette">Jocelyne Chiquette</name><affiliation><nlm:aff id="aff181"><addr-line>Unité de Recherche en Santé des Populations, Centre des Maladies du Sein Deschênes-Fabia, Centre de Recherche FRSQ du Centre Hospitalier Affilié Universitaire de Québec, Québec, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tihomirova, Laima" sort="Tihomirova, Laima" uniqKey="Tihomirova L" first="Laima" last="Tihomirova">Laima Tihomirova</name><affiliation><nlm:aff id="aff182"><addr-line>Latvian Biomedical Research and Study Centre, Riga, Latvia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Friebel, Tara M" sort="Friebel, Tara M" uniqKey="Friebel T" first="Tara M." last="Friebel">Tara M. Friebel</name><affiliation><nlm:aff id="aff183"><addr-line>University of Pennsylvania, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Agnarsson, Bjarni A" sort="Agnarsson, Bjarni A" uniqKey="Agnarsson B" first="Bjarni A." last="Agnarsson">Bjarni A. Agnarsson</name><affiliation><nlm:aff id="aff184"><addr-line>Landspitali University Hospital and University of Iceland School of Medicine, Reykjavik, Iceland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lu, Karen H" sort="Lu, Karen H" uniqKey="Lu K" first="Karen H." last="Lu">Karen H. Lu</name><affiliation><nlm:aff id="aff66"><addr-line>Department of Breast Medical Oncology and Clinical Cancer Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lejbkowicz, Flavio" sort="Lejbkowicz, Flavio" uniqKey="Lejbkowicz F" first="Flavio" last="Lejbkowicz">Flavio Lejbkowicz</name><affiliation><nlm:aff id="aff185"><addr-line>Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel</addr-line></nlm:aff></affiliation></author><author><name sortKey="James, Paul A" sort="James, Paul A" uniqKey="James P" first="Paul A." last="James">Paul A. James</name><affiliation><nlm:aff id="aff186"><addr-line>Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="aff187"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="aff188"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tessier, Daniel" sort="Tessier, Daniel" uniqKey="Tessier D" first="Daniel" last="Tessier">Daniel Tessier</name><affiliation><nlm:aff id="aff11"><addr-line>Centre d'Innovation Génome Québec et Université McGill, Montreal, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cunningham, Julie" sort="Cunningham, Julie" uniqKey="Cunningham J" first="Julie" last="Cunningham">Julie Cunningham</name><affiliation><nlm:aff id="aff1"><addr-line>Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Slager, Susan L" sort="Slager, Susan L" uniqKey="Slager S" first="Susan L." last="Slager">Susan L. Slager</name><affiliation><nlm:aff id="aff4"><addr-line>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wang, Chen" sort="Wang, Chen" uniqKey="Wang C" first="Chen" last="Wang">Chen Wang</name><affiliation><nlm:aff id="aff4"><addr-line>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hart, Steven" sort="Hart, Steven" uniqKey="Hart S" first="Steven" last="Hart">Steven Hart</name><affiliation><nlm:aff id="aff4"><addr-line>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stevens, Kristen" sort="Stevens, Kristen" uniqKey="Stevens K" first="Kristen" last="Stevens">Kristen Stevens</name><affiliation><nlm:aff id="aff1"><addr-line>Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="aff5"><addr-line>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pastinen, Tomi" sort="Pastinen, Tomi" uniqKey="Pastinen T" first="Tomi" last="Pastinen">Tomi Pastinen</name><affiliation><nlm:aff id="aff189"><addr-line>Department of Human Genetics, McGill University and Génome Québec Innovation Centre, McGill University, Montréal, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pankratz, Vernon S" sort="Pankratz, Vernon S" uniqKey="Pankratz V" first="Vernon S." last="Pankratz">Vernon S. Pankratz</name><affiliation><nlm:aff id="aff4"><addr-line>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><nlm:aff id="aff160"><addr-line>Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="aff7"><addr-line>Genetics Department, Queensland Institute of Medical Research, Brisbane, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name><affiliation><nlm:aff id="aff3"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS Genetics</title><idno type="ISSN">1553-7390</idno><idno type="eISSN">1553-7404</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>BRCA1</italic>-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 <italic>BRCA1</italic> carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 <italic>BRCA1</italic> carriers. We identified a novel breast cancer risk modifier locus at 1q32 for <italic>BRCA1</italic> carriers (rs2290854, P = 2.7×10<sup>−8</sup>, HR = 1.14, 95% CI: 1.09–1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10<sup>−8</sup>, HR = 1.27, 95% CI: 1.17–1.38) and 4q32.3 (rs4691139, P = 3.4×10<sup>−8</sup>, HR = 1.20, 95% CI: 1.17–1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or <italic>BRCA2</italic> carriers, suggesting a <italic>BRCA1</italic>-specific association. The 17q21.31 locus was also associated with ovarian cancer risk in 8,211 <italic>BRCA2</italic> carriers (P = 2×10<sup>−4</sup>). These loci may lead to an improved understanding of the etiology of breast and ovarian tumors in <italic>BRCA1</italic> carriers. Based on the joint distribution of the known <italic>BRCA1</italic> breast cancer risk-modifying loci, we estimated that the breast cancer lifetime risks for the 5% of <italic>BRCA1</italic> carriers at lowest risk are 28%–50% compared to 81%–100% for the 5% at highest risk. Similarly, based on the known ovarian cancer risk-modifying loci, the 5% of <italic>BRCA1</italic> carriers at lowest risk have an estimated lifetime risk of developing ovarian cancer of 28% or lower, whereas the 5% at highest risk will have a risk of 63% or higher. Such differences in risk may have important implications for risk prediction and clinical management for <italic>BRCA1</italic> carriers.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Antoniou, A" uniqKey="Antoniou A">A Antoniou</name></author><author><name sortKey="Pharoah, Pd" uniqKey="Pharoah P">PD Pharoah</name></author><author><name sortKey="Narod, S" uniqKey="Narod S">S Narod</name></author><author><name sortKey="Risch, Ha" uniqKey="Risch H">HA Risch</name></author><author><name sortKey="Eyfjord, Je" uniqKey="Eyfjord J">JE Eyfjord</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Antoniou, Ac" uniqKey="Antoniou A">AC Antoniou</name></author><author><name sortKey="Chenevix Trench, G" uniqKey="Chenevix Trench G">G Chenevix-Trench</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Begg, Cb" uniqKey="Begg C">CB Begg</name></author><author><name sortKey="Haile, 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS Genet</journal-id><journal-id journal-id-type="iso-abbrev">PLoS Genet</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosgen</journal-id><journal-title-group><journal-title>PLoS Genetics</journal-title></journal-title-group><issn pub-type="ppub">1553-7390</issn><issn pub-type="epub">1553-7404</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23544013</article-id><article-id pub-id-type="pmc">3609646</article-id><article-id pub-id-type="publisher-id">PGENETICS-D-12-02260</article-id><article-id pub-id-type="doi">10.1371/journal.pgen.1003212</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Biology</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine</subject></subj-group></article-categories><title-group><article-title>Genome-Wide Association Study in <italic>BRCA1</italic> Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk</article-title><alt-title alt-title-type="running-head">Novel Modifiers of <italic>BRCA1</italic> Cancer Risk</alt-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Couch</surname><given-names>Fergus J.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Xianshu</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>McGuffog</surname><given-names>Lesley</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Andrew</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Olswold</surname><given-names>Curtis</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kuchenbaecker</surname><given-names>Karoline B.</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Soucy</surname><given-names>Penny</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fredericksen</surname><given-names>Zachary</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Barrowdale</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dennis</surname><given-names>Joe</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gaudet</surname><given-names>Mia M.</given-names></name><xref ref-type="aff" rid="aff6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dicks</surname><given-names>Ed</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kosel</surname><given-names>Matthew</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Healey</surname><given-names>Sue</given-names></name><xref ref-type="aff" rid="aff7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sinilnikova</surname><given-names>Olga M.</given-names></name><xref ref-type="aff" rid="aff8"><sup>8</sup></xref><xref ref-type="aff" rid="aff9"><sup>9</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Adam</given-names></name><xref ref-type="aff" rid="aff10"><sup>10</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bacot</surname><given-names>François</given-names></name><xref ref-type="aff" rid="aff11"><sup>11</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vincent</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="aff11"><sup>11</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hogervorst</surname><given-names>Frans B. 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contrib-type="author"><name><surname>Godwin</surname><given-names>Andrew K.</given-names></name><xref ref-type="aff" rid="aff40"><sup>40</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yannoukakos</surname><given-names>Drakoulis</given-names></name><xref ref-type="aff" rid="aff41"><sup>41</sup></xref></contrib><contrib contrib-type="author"><name><surname>Goldgar</surname><given-names>David E.</given-names></name><xref ref-type="aff" rid="aff42"><sup>42</sup></xref></contrib><contrib contrib-type="author"><name><surname>Caldes</surname><given-names>Trinidad</given-names></name><xref ref-type="aff" rid="aff43"><sup>43</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nevanlinna</surname><given-names>Heli</given-names></name><xref ref-type="aff" rid="aff44"><sup>44</sup></xref></contrib><contrib contrib-type="author"><name><surname>Osorio</surname><given-names>Ana</given-names></name><xref ref-type="aff" rid="aff45"><sup>45</sup></xref></contrib><contrib contrib-type="author"><name><surname>Terry</surname><given-names>Mary Beth</given-names></name><xref ref-type="aff" rid="aff46"><sup>46</sup></xref></contrib><contrib contrib-type="author"><name><surname>Daly</surname><given-names>Mary B.</given-names></name><xref ref-type="aff" rid="aff47"><sup>47</sup></xref></contrib><contrib contrib-type="author"><name><surname>van Rensburg</surname><given-names>Elizabeth J.</given-names></name><xref ref-type="aff" rid="aff48"><sup>48</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hamann</surname><given-names>Ute</given-names></name><xref ref-type="aff" rid="aff49"><sup>49</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ramus</surname><given-names>Susan J.</given-names></name><xref ref-type="aff" rid="aff50"><sup>50</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ewart Toland</surname><given-names>Amanda</given-names></name><xref ref-type="aff" rid="aff51"><sup>51</sup></xref></contrib><contrib contrib-type="author"><name><surname>Caligo</surname><given-names>Maria A.</given-names></name><xref ref-type="aff" rid="aff52"><sup>52</sup></xref></contrib><contrib contrib-type="author"><name><surname>Olopade</surname><given-names>Olufunmilayo I.</given-names></name><xref ref-type="aff" rid="aff53"><sup>53</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tung</surname><given-names>Nadine</given-names></name><xref ref-type="aff" rid="aff54"><sup>54</sup></xref></contrib><contrib contrib-type="author"><name><surname>Claes</surname><given-names>Kathleen</given-names></name><xref ref-type="aff" rid="aff55"><sup>55</sup></xref></contrib><contrib contrib-type="author"><name><surname>Beattie</surname><given-names>Mary S.</given-names></name><xref ref-type="aff" rid="aff56"><sup>56</sup></xref></contrib><contrib contrib-type="author"><name><surname>Southey</surname><given-names>Melissa C.</given-names></name><xref ref-type="aff" rid="aff57"><sup>57</sup></xref></contrib><contrib contrib-type="author"><name><surname>Imyanitov</surname><given-names>Evgeny N.</given-names></name><xref ref-type="aff" rid="aff58"><sup>58</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tischkowitz</surname><given-names>Marc</given-names></name><xref ref-type="aff" rid="aff59"><sup>59</sup></xref></contrib><contrib contrib-type="author"><name><surname>Janavicius</surname><given-names>Ramunas</given-names></name><xref ref-type="aff" rid="aff60"><sup>60</sup></xref></contrib><contrib contrib-type="author"><name><surname>John</surname><given-names>Esther M.</given-names></name><xref ref-type="aff" rid="aff61"><sup>61</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kwong</surname><given-names>Ava</given-names></name><xref ref-type="aff" rid="aff62"><sup>62</sup></xref></contrib><contrib contrib-type="author"><name><surname>Diez</surname><given-names>Orland</given-names></name><xref ref-type="aff" rid="aff63"><sup>63</sup></xref></contrib><contrib contrib-type="author"><name><surname>Balmaña</surname><given-names>Judith</given-names></name><xref ref-type="aff" rid="aff64"><sup>64</sup></xref></contrib><contrib contrib-type="author"><name><surname>Barkardottir</surname><given-names>Rosa B.</given-names></name><xref ref-type="aff" rid="aff65"><sup>65</sup></xref></contrib><contrib contrib-type="author"><name><surname>Arun</surname><given-names>Banu K.</given-names></name><xref ref-type="aff" rid="aff66"><sup>66</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rennert</surname><given-names>Gad</given-names></name><xref ref-type="aff" rid="aff67"><sup>67</sup></xref></contrib><contrib contrib-type="author"><name><surname>Teo</surname><given-names>Soo-Hwang</given-names></name><xref ref-type="aff" rid="aff68"><sup>68</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ganz</surname><given-names>Patricia A.</given-names></name><xref ref-type="aff" rid="aff69"><sup>69</sup></xref></contrib><contrib contrib-type="author"><name><surname>Campbell</surname><given-names>Ian</given-names></name><xref ref-type="aff" rid="aff70"><sup>70</sup></xref></contrib><contrib contrib-type="author"><name><surname>van der Hout</surname><given-names>Annemarie H.</given-names></name><xref ref-type="aff" rid="aff71"><sup>71</sup></xref></contrib><contrib contrib-type="author"><name><surname>van Deurzen</surname><given-names>Carolien H. M.</given-names></name><xref ref-type="aff" rid="aff72"><sup>72</sup></xref></contrib><contrib contrib-type="author"><name><surname>Seynaeve</surname><given-names>Caroline</given-names></name><xref ref-type="aff" rid="aff73"><sup>73</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gómez Garcia</surname><given-names>Encarna B.</given-names></name><xref ref-type="aff" rid="aff74"><sup>74</sup></xref></contrib><contrib contrib-type="author"><name><surname>van Leeuwen</surname><given-names>Flora E.</given-names></name><xref ref-type="aff" rid="aff75"><sup>75</sup></xref></contrib><contrib contrib-type="author"><name><surname>Meijers-Heijboer</surname><given-names>Hanne E. J.</given-names></name><xref ref-type="aff" rid="aff76"><sup>76</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gille</surname><given-names>Johannes J. P.</given-names></name><xref ref-type="aff" rid="aff76"><sup>76</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ausems</surname><given-names>Margreet G. E. M.</given-names></name><xref ref-type="aff" rid="aff77"><sup>77</sup></xref></contrib><contrib contrib-type="author"><name><surname>Blok</surname><given-names>Marinus J.</given-names></name><xref ref-type="aff" rid="aff78"><sup>78</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ligtenberg</surname><given-names>Marjolijn J. L.</given-names></name><xref ref-type="aff" rid="aff79"><sup>79</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rookus</surname><given-names>Matti A.</given-names></name><xref ref-type="aff" rid="aff75"><sup>75</sup></xref></contrib><contrib contrib-type="author"><name><surname>Devilee</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="aff80"><sup>80</sup></xref></contrib><contrib contrib-type="author"><name><surname>Verhoef</surname><given-names>Senno</given-names></name><xref ref-type="aff" rid="aff12"><sup>12</sup></xref></contrib><contrib contrib-type="author"><name><surname>van Os</surname><given-names>Theo A. M.</given-names></name><xref ref-type="aff" rid="aff81"><sup>81</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wijnen</surname><given-names>Juul T.</given-names></name><xref ref-type="aff" rid="aff82"><sup>82</sup></xref></contrib><contrib contrib-type="author"><collab>HEBON</collab><xref ref-type="aff" rid="aff83"><sup>83</sup></xref></contrib><contrib contrib-type="author"><collab>EMBRACE</collab><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Frost</surname><given-names>Debra</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ellis</surname><given-names>Steve</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fineberg</surname><given-names>Elena</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Platte</surname><given-names>Radka</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Evans</surname><given-names>D. Gareth</given-names></name><xref ref-type="aff" rid="aff84"><sup>84</sup></xref></contrib><contrib contrib-type="author"><name><surname>Izatt</surname><given-names>Louise</given-names></name><xref ref-type="aff" rid="aff85"><sup>85</sup></xref></contrib><contrib contrib-type="author"><name><surname>Eeles</surname><given-names>Rosalind A.</given-names></name><xref ref-type="aff" rid="aff86"><sup>86</sup></xref></contrib><contrib contrib-type="author"><name><surname>Adlard</surname><given-names>Julian</given-names></name><xref ref-type="aff" rid="aff87"><sup>87</sup></xref></contrib><contrib contrib-type="author"><name><surname>Eccles</surname><given-names>Diana M.</given-names></name><xref ref-type="aff" rid="aff88"><sup>88</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cook</surname><given-names>Jackie</given-names></name><xref ref-type="aff" rid="aff89"><sup>89</sup></xref></contrib><contrib contrib-type="author"><name><surname>Brewer</surname><given-names>Carole</given-names></name><xref ref-type="aff" rid="aff90"><sup>90</sup></xref></contrib><contrib contrib-type="author"><name><surname>Douglas</surname><given-names>Fiona</given-names></name><xref ref-type="aff" rid="aff91"><sup>91</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hodgson</surname><given-names>Shirley</given-names></name><xref ref-type="aff" rid="aff92"><sup>92</sup></xref></contrib><contrib contrib-type="author"><name><surname>Morrison</surname><given-names>Patrick J.</given-names></name><xref ref-type="aff" rid="aff93"><sup>93</sup></xref></contrib><contrib contrib-type="author"><name><surname>Side</surname><given-names>Lucy E.</given-names></name><xref ref-type="aff" rid="aff94"><sup>94</sup></xref></contrib><contrib contrib-type="author"><name><surname>Donaldson</surname><given-names>Alan</given-names></name><xref ref-type="aff" rid="aff95"><sup>95</sup></xref></contrib><contrib contrib-type="author"><name><surname>Houghton</surname><given-names>Catherine</given-names></name><xref ref-type="aff" rid="aff96"><sup>96</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rogers</surname><given-names>Mark T.</given-names></name><xref ref-type="aff" rid="aff97"><sup>97</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dorkins</surname><given-names>Huw</given-names></name><xref ref-type="aff" rid="aff98"><sup>98</sup></xref></contrib><contrib contrib-type="author"><name><surname>Eason</surname><given-names>Jacqueline</given-names></name><xref ref-type="aff" rid="aff99"><sup>99</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gregory</surname><given-names>Helen</given-names></name><xref ref-type="aff" rid="aff100"><sup>100</sup></xref></contrib><contrib contrib-type="author"><name><surname>McCann</surname><given-names>Emma</given-names></name><xref ref-type="aff" rid="aff101"><sup>101</sup></xref></contrib><contrib contrib-type="author"><name><surname>Murray</surname><given-names>Alex</given-names></name><xref ref-type="aff" rid="aff102"><sup>102</sup></xref></contrib><contrib contrib-type="author"><name><surname>Calender</surname><given-names>Alain</given-names></name><xref ref-type="aff" rid="aff8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hardouin</surname><given-names>Agnès</given-names></name><xref ref-type="aff" rid="aff103"><sup>103</sup></xref></contrib><contrib contrib-type="author"><name><surname>Berthet</surname><given-names>Pascaline</given-names></name><xref ref-type="aff" rid="aff103"><sup>103</sup></xref></contrib><contrib contrib-type="author"><name><surname>Delnatte</surname><given-names>Capucine</given-names></name><xref ref-type="aff" rid="aff104"><sup>104</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nogues</surname><given-names>Catherine</given-names></name><xref ref-type="aff" rid="aff105"><sup>105</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lasset</surname><given-names>Christine</given-names></name><xref ref-type="aff" rid="aff106"><sup>106</sup></xref><xref ref-type="aff" rid="aff107"><sup>107</sup></xref></contrib><contrib contrib-type="author"><name><surname>Houdayer</surname><given-names>Claude</given-names></name><xref ref-type="aff" rid="aff13"><sup>13</sup></xref><xref ref-type="aff" rid="aff15"><sup>15</sup></xref></contrib><contrib contrib-type="author"><name><surname>Leroux</surname><given-names>Dominique</given-names></name><xref ref-type="aff" rid="aff108"><sup>108</sup></xref><xref ref-type="aff" rid="aff109"><sup>109</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rouleau</surname><given-names>Etienne</given-names></name><xref ref-type="aff" rid="aff110"><sup>110</sup></xref></contrib><contrib contrib-type="author"><name><surname>Prieur</surname><given-names>Fabienne</given-names></name><xref ref-type="aff" rid="aff111"><sup>111</sup></xref></contrib><contrib contrib-type="author"><name><surname>Damiola</surname><given-names>Francesca</given-names></name><xref ref-type="aff" rid="aff9"><sup>9</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sobol</surname><given-names>Hagay</given-names></name><xref ref-type="aff" rid="aff112"><sup>112</sup></xref></contrib><contrib contrib-type="author"><name><surname>Coupier</surname><given-names>Isabelle</given-names></name><xref ref-type="aff" rid="aff113"><sup>113</sup></xref><xref ref-type="aff" rid="aff114"><sup>114</sup></xref></contrib><contrib contrib-type="author"><name><surname>Venat-Bouvet</surname><given-names>Laurence</given-names></name><xref ref-type="aff" rid="aff115"><sup>115</sup></xref></contrib><contrib contrib-type="author"><name><surname>Castera</surname><given-names>Laurent</given-names></name><xref ref-type="aff" rid="aff13"><sup>13</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gauthier-Villars</surname><given-names>Marion</given-names></name><xref ref-type="aff" rid="aff13"><sup>13</sup></xref></contrib><contrib contrib-type="author"><name><surname>Léoné</surname><given-names>Mélanie</given-names></name><xref ref-type="aff" rid="aff8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pujol</surname><given-names>Pascal</given-names></name><xref ref-type="aff" rid="aff113"><sup>113</sup></xref><xref ref-type="aff" rid="aff116"><sup>116</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mazoyer</surname><given-names>Sylvie</given-names></name><xref ref-type="aff" rid="aff9"><sup>9</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bignon</surname><given-names>Yves-Jean</given-names></name><xref ref-type="aff" rid="aff117"><sup>117</sup></xref></contrib><contrib contrib-type="author"><collab>GEMO Study Collaborators</collab><xref ref-type="aff" rid="aff118"><sup>118</sup></xref></contrib><contrib contrib-type="author"><name><surname>Złowocka-Perłowska</surname><given-names>Elżbieta</given-names></name><xref ref-type="aff" rid="aff16"><sup>16</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gronwald</surname><given-names>Jacek</given-names></name><xref ref-type="aff" rid="aff16"><sup>16</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lubinski</surname><given-names>Jan</given-names></name><xref ref-type="aff" rid="aff16"><sup>16</sup></xref></contrib><contrib contrib-type="author"><name><surname>Durda</surname><given-names>Katarzyna</given-names></name><xref ref-type="aff" rid="aff16"><sup>16</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jaworska</surname><given-names>Katarzyna</given-names></name><xref ref-type="aff" rid="aff16"><sup>16</sup></xref><xref ref-type="aff" rid="aff119"><sup>119</sup></xref></contrib><contrib contrib-type="author"><name><surname>Huzarski</surname><given-names>Tomasz</given-names></name><xref ref-type="aff" rid="aff16"><sup>16</sup></xref></contrib><contrib contrib-type="author"><name><surname>Spurdle</surname><given-names>Amanda B.</given-names></name><xref ref-type="aff" rid="aff7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Viel</surname><given-names>Alessandra</given-names></name><xref ref-type="aff" rid="aff120"><sup>120</sup></xref></contrib><contrib contrib-type="author"><name><surname>Peissel</surname><given-names>Bernard</given-names></name><xref ref-type="aff" rid="aff121"><sup>121</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bonanni</surname><given-names>Bernardo</given-names></name><xref ref-type="aff" rid="aff122"><sup>122</sup></xref></contrib><contrib contrib-type="author"><name><surname>Melloni</surname><given-names>Giulia</given-names></name><xref ref-type="aff" rid="aff121"><sup>121</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ottini</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="aff123"><sup>123</sup></xref></contrib><contrib contrib-type="author"><name><surname>Papi</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="aff124"><sup>124</sup></xref></contrib><contrib contrib-type="author"><name><surname>Varesco</surname><given-names>Liliana</given-names></name><xref ref-type="aff" rid="aff125"><sup>125</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tibiletti</surname><given-names>Maria Grazia</given-names></name><xref ref-type="aff" rid="aff126"><sup>126</sup></xref></contrib><contrib contrib-type="author"><name><surname>Peterlongo</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="aff18"><sup>18</sup></xref><xref ref-type="aff" rid="aff19"><sup>19</sup></xref></contrib><contrib contrib-type="author"><name><surname>Volorio</surname><given-names>Sara</given-names></name><xref ref-type="aff" rid="aff127"><sup>127</sup></xref></contrib><contrib contrib-type="author"><name><surname>Manoukian</surname><given-names>Siranoush</given-names></name><xref ref-type="aff" rid="aff121"><sup>121</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pensotti</surname><given-names>Valeria</given-names></name><xref ref-type="aff" rid="aff127"><sup>127</sup></xref></contrib><contrib contrib-type="author"><name><surname>Arnold</surname><given-names>Norbert</given-names></name><xref ref-type="aff" rid="aff128"><sup>128</sup></xref></contrib><contrib contrib-type="author"><name><surname>Engel</surname><given-names>Christoph</given-names></name><xref ref-type="aff" rid="aff129"><sup>129</sup></xref></contrib><contrib contrib-type="author"><name><surname>Deissler</surname><given-names>Helmut</given-names></name><xref ref-type="aff" rid="aff130"><sup>130</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gadzicki</surname><given-names>Dorothea</given-names></name><xref ref-type="aff" rid="aff131"><sup>131</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gehrig</surname><given-names>Andrea</given-names></name><xref ref-type="aff" rid="aff132"><sup>132</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kast</surname><given-names>Karin</given-names></name><xref ref-type="aff" rid="aff133"><sup>133</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rhiem</surname><given-names>Kerstin</given-names></name><xref ref-type="aff" rid="aff20"><sup>20</sup></xref></contrib><contrib contrib-type="author"><name><surname>Meindl</surname><given-names>Alfons</given-names></name><xref ref-type="aff" rid="aff134"><sup>134</sup></xref></contrib><contrib contrib-type="author"><name><surname>Niederacher</surname><given-names>Dieter</given-names></name><xref ref-type="aff" rid="aff135"><sup>135</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ditsch</surname><given-names>Nina</given-names></name><xref ref-type="aff" rid="aff136"><sup>136</sup></xref></contrib><contrib contrib-type="author"><name><surname>Plendl</surname><given-names>Hansjoerg</given-names></name><xref ref-type="aff" rid="aff137"><sup>137</sup></xref></contrib><contrib contrib-type="author"><name><surname>Preisler-Adams</surname><given-names>Sabine</given-names></name><xref ref-type="aff" rid="aff138"><sup>138</sup></xref></contrib><contrib contrib-type="author"><name><surname>Engert</surname><given-names>Stefanie</given-names></name><xref ref-type="aff" rid="aff134"><sup>134</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sutter</surname><given-names>Christian</given-names></name><xref ref-type="aff" rid="aff139"><sup>139</sup></xref></contrib><contrib contrib-type="author"><name><surname>Varon-Mateeva</surname><given-names>Raymonda</given-names></name><xref ref-type="aff" rid="aff140"><sup>140</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wappenschmidt</surname><given-names>Barbara</given-names></name><xref ref-type="aff" rid="aff20"><sup>20</sup></xref></contrib><contrib contrib-type="author"><name><surname>Weber</surname><given-names>Bernhard H. F.</given-names></name><xref ref-type="aff" rid="aff141"><sup>141</sup></xref></contrib><contrib contrib-type="author"><name><surname>Arver</surname><given-names>Brita</given-names></name><xref ref-type="aff" rid="aff142"><sup>142</sup></xref></contrib><contrib contrib-type="author"><name><surname>Stenmark-Askmalm</surname><given-names>Marie</given-names></name><xref ref-type="aff" rid="aff143"><sup>143</sup></xref></contrib><contrib contrib-type="author"><name><surname>Loman</surname><given-names>Niklas</given-names></name><xref ref-type="aff" rid="aff144"><sup>144</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rosenquist</surname><given-names>Richard</given-names></name><xref ref-type="aff" rid="aff145"><sup>145</sup></xref></contrib><contrib contrib-type="author"><name><surname>Einbeigi</surname><given-names>Zakaria</given-names></name><xref ref-type="aff" rid="aff146"><sup>146</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nathanson</surname><given-names>Katherine L.</given-names></name><xref ref-type="aff" rid="aff147"><sup>147</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rebbeck</surname><given-names>Timothy R.</given-names></name><xref ref-type="aff" rid="aff148"><sup>148</sup></xref></contrib><contrib contrib-type="author"><name><surname>Blank</surname><given-names>Stephanie V.</given-names></name><xref ref-type="aff" rid="aff149"><sup>149</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cohn</surname><given-names>David E.</given-names></name><xref ref-type="aff" rid="aff150"><sup>150</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rodriguez</surname><given-names>Gustavo C.</given-names></name><xref ref-type="aff" rid="aff151"><sup>151</sup></xref></contrib><contrib contrib-type="author"><name><surname>Small</surname><given-names>Laurie</given-names></name><xref ref-type="aff" rid="aff152"><sup>152</sup></xref></contrib><contrib contrib-type="author"><name><surname>Friedlander</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="aff153"><sup>153</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bae-Jump</surname><given-names>Victoria L.</given-names></name><xref ref-type="aff" rid="aff154"><sup>154</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fink-Retter</surname><given-names>Anneliese</given-names></name><xref ref-type="aff" rid="aff24"><sup>24</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rappaport</surname><given-names>Christine</given-names></name><xref ref-type="aff" rid="aff24"><sup>24</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gschwantler-Kaulich</surname><given-names>Daphne</given-names></name><xref ref-type="aff" rid="aff24"><sup>24</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pfeiler</surname><given-names>Georg</given-names></name><xref ref-type="aff" rid="aff24"><sup>24</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tea</surname><given-names>Muy-Kheng</given-names></name><xref ref-type="aff" rid="aff24"><sup>24</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lindor</surname><given-names>Noralane M.</given-names></name><xref ref-type="aff" rid="aff155"><sup>155</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kaufman</surname><given-names>Bella</given-names></name><xref ref-type="aff" rid="aff25"><sup>25</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shimon Paluch</surname><given-names>Shani</given-names></name><xref ref-type="aff" rid="aff25"><sup>25</sup></xref></contrib><contrib contrib-type="author"><name><surname>Laitman</surname><given-names>Yael</given-names></name><xref ref-type="aff" rid="aff25"><sup>25</sup></xref></contrib><contrib contrib-type="author"><name><surname>Skytte</surname><given-names>Anne-Bine</given-names></name><xref ref-type="aff" rid="aff156"><sup>156</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gerdes</surname><given-names>Anne-Marie</given-names></name><xref ref-type="aff" rid="aff157"><sup>157</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pedersen</surname><given-names>Inge Sokilde</given-names></name><xref ref-type="aff" rid="aff158"><sup>158</sup></xref></contrib><contrib contrib-type="author"><name><surname>Moeller</surname><given-names>Sanne Traasdahl</given-names></name><xref ref-type="aff" rid="aff26"><sup>26</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kruse</surname><given-names>Torben A.</given-names></name><xref ref-type="aff" rid="aff26"><sup>26</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jensen</surname><given-names>Uffe Birk</given-names></name><xref ref-type="aff" rid="aff159"><sup>159</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vijai</surname><given-names>Joseph</given-names></name><xref ref-type="aff" rid="aff160"><sup>160</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sarrel</surname><given-names>Kara</given-names></name><xref ref-type="aff" rid="aff160"><sup>160</sup></xref></contrib><contrib contrib-type="author"><name><surname>Robson</surname><given-names>Mark</given-names></name><xref ref-type="aff" rid="aff160"><sup>160</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kauff</surname><given-names>Noah</given-names></name><xref ref-type="aff" rid="aff160"><sup>160</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mulligan</surname><given-names>Anna Marie</given-names></name><xref ref-type="aff" rid="aff161"><sup>161</sup></xref><xref ref-type="aff" rid="aff162"><sup>162</sup></xref></contrib><contrib contrib-type="author"><name><surname>Glendon</surname><given-names>Gord</given-names></name><xref ref-type="aff" rid="aff27"><sup>27</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ozcelik</surname><given-names>Hilmi</given-names></name><xref ref-type="aff" rid="aff39"><sup>39</sup></xref><xref ref-type="aff" rid="aff161"><sup>161</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ejlertsen</surname><given-names>Bent</given-names></name><xref ref-type="aff" rid="aff163"><sup>163</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nielsen</surname><given-names>Finn C.</given-names></name><xref ref-type="aff" rid="aff28"><sup>28</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jønson</surname><given-names>Lars</given-names></name><xref ref-type="aff" rid="aff28"><sup>28</sup></xref></contrib><contrib contrib-type="author"><name><surname>Andersen</surname><given-names>Mette K.</given-names></name><xref ref-type="aff" rid="aff164"><sup>164</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ding</surname><given-names>Yuan Chun</given-names></name><xref ref-type="aff" rid="aff29"><sup>29</sup></xref></contrib><contrib contrib-type="author"><name><surname>Steele</surname><given-names>Linda</given-names></name><xref ref-type="aff" rid="aff29"><sup>29</sup></xref></contrib><contrib contrib-type="author"><name><surname>Foretova</surname><given-names>Lenka</given-names></name><xref ref-type="aff" rid="aff165"><sup>165</sup></xref></contrib><contrib contrib-type="author"><name><surname>Teulé</surname><given-names>Alex</given-names></name><xref ref-type="aff" rid="aff31"><sup>31</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lazaro</surname><given-names>Conxi</given-names></name><xref ref-type="aff" rid="aff166"><sup>166</sup></xref></contrib><contrib contrib-type="author"><name><surname>Brunet</surname><given-names>Joan</given-names></name><xref ref-type="aff" rid="aff167"><sup>167</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pujana</surname><given-names>Miquel Angel</given-names></name><xref ref-type="aff" rid="aff168"><sup>168</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mai</surname><given-names>Phuong L.</given-names></name><xref ref-type="aff" rid="aff32"><sup>32</sup></xref></contrib><contrib contrib-type="author"><name><surname>Loud</surname><given-names>Jennifer T.</given-names></name><xref ref-type="aff" rid="aff32"><sup>32</sup></xref></contrib><contrib contrib-type="author"><name><surname>Walsh</surname><given-names>Christine</given-names></name><xref ref-type="aff" rid="aff33"><sup>33</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lester</surname><given-names>Jenny</given-names></name><xref ref-type="aff" rid="aff33"><sup>33</sup></xref></contrib><contrib contrib-type="author"><name><surname>Orsulic</surname><given-names>Sandra</given-names></name><xref ref-type="aff" rid="aff33"><sup>33</sup></xref></contrib><contrib contrib-type="author"><name><surname>Narod</surname><given-names>Steven A.</given-names></name><xref ref-type="aff" rid="aff169"><sup>169</sup></xref></contrib><contrib contrib-type="author"><name><surname>Herzog</surname><given-names>Josef</given-names></name><xref ref-type="aff" rid="aff36"><sup>36</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sand</surname><given-names>Sharon R.</given-names></name><xref ref-type="aff" rid="aff36"><sup>36</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tognazzo</surname><given-names>Silvia</given-names></name><xref ref-type="aff" rid="aff37"><sup>37</sup></xref></contrib><contrib contrib-type="author"><name><surname>Agata</surname><given-names>Simona</given-names></name><xref ref-type="aff" rid="aff37"><sup>37</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vaszko</surname><given-names>Tibor</given-names></name><xref ref-type="aff" rid="aff38"><sup>38</sup></xref></contrib><contrib contrib-type="author"><name><surname>Weaver</surname><given-names>Joellen</given-names></name><xref ref-type="aff" rid="aff170"><sup>170</sup></xref></contrib><contrib contrib-type="author"><name><surname>Stavropoulou</surname><given-names>Alexandra V.</given-names></name><xref ref-type="aff" rid="aff41"><sup>41</sup></xref></contrib><contrib contrib-type="author"><name><surname>Buys</surname><given-names>Saundra S.</given-names></name><xref ref-type="aff" rid="aff171"><sup>171</sup></xref></contrib><contrib contrib-type="author"><name><surname>Romero</surname><given-names>Atocha</given-names></name><xref ref-type="aff" rid="aff43"><sup>43</sup></xref></contrib><contrib contrib-type="author"><name><surname>de la Hoya</surname><given-names>Miguel</given-names></name><xref ref-type="aff" rid="aff43"><sup>43</sup></xref></contrib><contrib contrib-type="author"><name><surname>Aittomäki</surname><given-names>Kristiina</given-names></name><xref ref-type="aff" rid="aff172"><sup>172</sup></xref></contrib><contrib contrib-type="author"><name><surname>Muranen</surname><given-names>Taru A.</given-names></name><xref ref-type="aff" rid="aff44"><sup>44</sup></xref></contrib><contrib contrib-type="author"><name><surname>Duran</surname><given-names>Mercedes</given-names></name><xref ref-type="aff" rid="aff173"><sup>173</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chung</surname><given-names>Wendy K.</given-names></name><xref ref-type="aff" rid="aff174"><sup>174</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lasa</surname><given-names>Adriana</given-names></name><xref ref-type="aff" rid="aff175"><sup>175</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dorfling</surname><given-names>Cecilia M.</given-names></name><xref ref-type="aff" rid="aff48"><sup>48</sup></xref></contrib><contrib contrib-type="author"><name><surname>Miron</surname><given-names>Alexander</given-names></name><xref ref-type="aff" rid="aff176"><sup>176</sup></xref></contrib><contrib contrib-type="author"><collab>BCFR</collab><xref ref-type="aff" rid="aff177"><sup>177</sup></xref></contrib><contrib contrib-type="author"><name><surname>Benitez</surname><given-names>Javier</given-names></name><xref ref-type="aff" rid="aff178"><sup>178</sup></xref></contrib><contrib contrib-type="author"><name><surname>Senter</surname><given-names>Leigha</given-names></name><xref ref-type="aff" rid="aff179"><sup>179</sup></xref></contrib><contrib contrib-type="author"><name><surname>Huo</surname><given-names>Dezheng</given-names></name><xref ref-type="aff" rid="aff53"><sup>53</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chan</surname><given-names>Salina B.</given-names></name><xref ref-type="aff" rid="aff180"><sup>180</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sokolenko</surname><given-names>Anna P.</given-names></name><xref ref-type="aff" rid="aff58"><sup>58</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chiquette</surname><given-names>Jocelyne</given-names></name><xref ref-type="aff" rid="aff181"><sup>181</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tihomirova</surname><given-names>Laima</given-names></name><xref ref-type="aff" rid="aff182"><sup>182</sup></xref></contrib><contrib contrib-type="author"><name><surname>Friebel</surname><given-names>Tara M.</given-names></name><xref ref-type="aff" rid="aff183"><sup>183</sup></xref></contrib><contrib contrib-type="author"><name><surname>Agnarsson</surname><given-names>Bjarni A.</given-names></name><xref ref-type="aff" rid="aff184"><sup>184</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lu</surname><given-names>Karen H.</given-names></name><xref ref-type="aff" rid="aff66"><sup>66</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lejbkowicz</surname><given-names>Flavio</given-names></name><xref ref-type="aff" rid="aff185"><sup>185</sup></xref></contrib><contrib contrib-type="author"><name><surname>James</surname><given-names>Paul A.</given-names></name><xref ref-type="aff" rid="aff186"><sup>186</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>Per</given-names></name><xref ref-type="aff" rid="aff187"><sup>187</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dunning</surname><given-names>Alison M.</given-names></name><xref ref-type="aff" rid="aff188"><sup>188</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tessier</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="aff11"><sup>11</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cunningham</surname><given-names>Julie</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Slager</surname><given-names>Susan L.</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Chen</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hart</surname><given-names>Steven</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Stevens</surname><given-names>Kristen</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Simard</surname><given-names>Jacques</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pastinen</surname><given-names>Tomi</given-names></name><xref ref-type="aff" rid="aff189"><sup>189</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pankratz</surname><given-names>Vernon S.</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Offit</surname><given-names>Kenneth</given-names></name><xref ref-type="aff" rid="aff160"><sup>160</sup></xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Easton</surname><given-names>Douglas F.</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><xref ref-type="aff" rid="aff7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Antoniou</surname><given-names>Antonis C.</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><collab>on behalf of CIMBA</collab></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></aff><aff id="aff3"><label>3</label><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line></aff><aff id="aff4"><label>4</label><addr-line>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></aff><aff id="aff5"><label>5</label><addr-line>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Canada</addr-line></aff><aff id="aff6"><label>6</label><addr-line>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, United States of America</addr-line></aff><aff id="aff7"><label>7</label><addr-line>Genetics Department, Queensland Institute of Medical Research, Brisbane, Australia</addr-line></aff><aff id="aff8"><label>8</label><addr-line>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon–Centre Léon Bérard, Lyon, France</addr-line></aff><aff id="aff9"><label>9</label><addr-line>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</addr-line></aff><aff id="aff10"><label>10</label><addr-line>Department of Molecular Pharmacology and Experimental Therapeutics (MPET), Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></aff><aff id="aff11"><label>11</label><addr-line>Centre d'Innovation Génome Québec et Université McGill, Montreal, Canada</addr-line></aff><aff id="aff12"><label>12</label><addr-line>Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands</addr-line></aff><aff id="aff13"><label>13</label><addr-line>Institut Curie, Department of Tumour Biology, Paris, France</addr-line></aff><aff id="aff14"><label>14</label><addr-line>Institut Curie, INSERM U830, Paris, France</addr-line></aff><aff id="aff15"><label>15</label><addr-line>Université Paris Descartes, Sorbonne Paris Cité, Paris, France</addr-line></aff><aff id="aff16"><label>16</label><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line></aff><aff id="aff17"><label>17</label><addr-line>Kathleen Cuningham Consortium for Research into Familial Breast Cancer–Peter MacCallum Cancer Center, Melbourne, Australia</addr-line></aff><aff id="aff18"><label>18</label><addr-line>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</addr-line></aff><aff id="aff19"><label>19</label><addr-line>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</addr-line></aff><aff id="aff20"><label>20</label><addr-line>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne, Germany</addr-line></aff><aff id="aff21"><label>21</label><addr-line>Department of Oncology, Lund University, Lund, Sweden</addr-line></aff><aff id="aff22"><label>22</label><addr-line>Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America</addr-line></aff><aff id="aff23"><label>23</label><addr-line>Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, New York, United States of America</addr-line></aff><aff id="aff24"><label>24</label><addr-line>Department of Obstetrics and Gynecology, and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</addr-line></aff><aff id="aff25"><label>25</label><addr-line>Sheba Medical Center, Tel Aviv, Israel</addr-line></aff><aff id="aff26"><label>26</label><addr-line>Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</addr-line></aff><aff id="aff27"><label>27</label><addr-line>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada</addr-line></aff><aff id="aff28"><label>28</label><addr-line>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</addr-line></aff><aff id="aff29"><label>29</label><addr-line>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, United States of America</addr-line></aff><aff id="aff30"><label>30</label><addr-line>Center for Translational Cancer Research, Department of Biological Sciences, University of Delaware, Newark, Delaware, United States of America</addr-line></aff><aff id="aff31"><label>31</label><addr-line>Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL–Catalan Institute of Oncology, Barcelona, Spain</addr-line></aff><aff id="aff32"><label>32</label><addr-line>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, United States of America</addr-line></aff><aff id="aff33"><label>33</label><addr-line>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America</addr-line></aff><aff id="aff34"><label>34</label><addr-line>Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America</addr-line></aff><aff id="aff35"><label>35</label><addr-line>Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America</addr-line></aff><aff id="aff36"><label>36</label><addr-line>Clinical Cancer Genetics (for the City of Hope Clinical Cancer Genetics Community Research Network), City of Hope, Duarte, California, United States of America</addr-line></aff><aff id="aff37"><label>37</label><addr-line>Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV–IRCCS, Padua, Italy</addr-line></aff><aff id="aff38"><label>38</label><addr-line>Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary</addr-line></aff><aff id="aff39"><label>39</label><addr-line>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</addr-line></aff><aff id="aff40"><label>40</label><addr-line>Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America</addr-line></aff><aff id="aff41"><label>41</label><addr-line>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research Demokritos, Aghia Paraskevi Attikis, Athens, Greece</addr-line></aff><aff id="aff42"><label>42</label><addr-line>Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America</addr-line></aff><aff id="aff43"><label>43</label><addr-line>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid, Spain</addr-line></aff><aff id="aff44"><label>44</label><addr-line>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</addr-line></aff><aff id="aff45"><label>45</label><addr-line>Human Genetics Group, Spanish National Cancer Centre (CNIO), and Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</addr-line></aff><aff id="aff46"><label>46</label><addr-line>Department of Epidemiology, Columbia University, New York, New York, United States of America</addr-line></aff><aff id="aff47"><label>47</label><addr-line>Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America</addr-line></aff><aff id="aff48"><label>48</label><addr-line>Department of Genetics, University of Pretoria, Pretoria, South Africa</addr-line></aff><aff id="aff49"><label>49</label><addr-line>Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany</addr-line></aff><aff id="aff50"><label>50</label><addr-line>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, California, United States of America</addr-line></aff><aff id="aff51"><label>51</label><addr-line>Divison of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America</addr-line></aff><aff id="aff52"><label>52</label><addr-line>Section of Genetic Oncology, Department of Laboratory Medicine, University of Pisa and University Hospital of Pisa, Pisa, Italy</addr-line></aff><aff id="aff53"><label>53</label><addr-line>Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois, United States of America</addr-line></aff><aff id="aff54"><label>54</label><addr-line>Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America</addr-line></aff><aff id="aff55"><label>55</label><addr-line>Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium</addr-line></aff><aff id="aff56"><label>56</label><addr-line>Departments of Medicine, Epidemiology, and Biostatistics, University of California San Francisco, San Francisco, California, United States of America</addr-line></aff><aff id="aff57"><label>57</label><addr-line>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Australia</addr-line></aff><aff id="aff58"><label>58</label><addr-line>N. N. Petrov Institute of Oncology, St. Petersburg, Russia</addr-line></aff><aff id="aff59"><label>59</label><addr-line>Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada</addr-line></aff><aff id="aff60"><label>60</label><addr-line>Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius, Lithuania</addr-line></aff><aff id="aff61"><label>61</label><addr-line>Department of Epidemiology, Cancer Prevention Institute of California, Fremont, Califoria, United States of America</addr-line></aff><aff id="aff62"><label>62</label><addr-line>The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong, China</addr-line></aff><aff id="aff63"><label>63</label><addr-line>Oncogenetics Laboratory, University Hospital Vall d'Hebron and Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain</addr-line></aff><aff id="aff64"><label>64</label><addr-line>Department of Medical Oncology, University Hospital, Vall d'Hebron, Barcelona, Spain</addr-line></aff><aff id="aff65"><label>65</label><addr-line>Department of Pathology, Landspitali University Hospital and BMC, Faculty of Medicine, University of Iceland, Reykjavik, Iceland</addr-line></aff><aff id="aff66"><label>66</label><addr-line>Department of Breast Medical Oncology and Clinical Cancer Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America</addr-line></aff><aff id="aff67"><label>67</label><addr-line>Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Haifa, Israel</addr-line></aff><aff id="aff68"><label>68</label><addr-line>Cancer Research Initiatives Foundation, Sime Darby Medical Centre and University Malaya Cancer Research Institute, University of Malaya, Kuala Lumpur, Malaysia</addr-line></aff><aff id="aff69"><label>69</label><addr-line>UCLA Schools of Medicine and Public Health, Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, Los Angeles, California, United States of America</addr-line></aff><aff id="aff70"><label>70</label><addr-line>VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Australia</addr-line></aff><aff id="aff71"><label>71</label><addr-line>Department of Genetics, University Medical Center, Groningen University, Groningen, The Netherlands</addr-line></aff><aff id="aff72"><label>72</label><addr-line>Department of Pathology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></aff><aff id="aff73"><label>73</label><addr-line>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></aff><aff id="aff74"><label>74</label><addr-line>Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, MUMC, Maastricht, The Netherlands</addr-line></aff><aff id="aff75"><label>75</label><addr-line>Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</addr-line></aff><aff id="aff76"><label>76</label><addr-line>Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands</addr-line></aff><aff id="aff77"><label>77</label><addr-line>Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</addr-line></aff><aff id="aff78"><label>78</label><addr-line>Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands</addr-line></aff><aff id="aff79"><label>79</label><addr-line>Department of Human Genetics and Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</addr-line></aff><aff id="aff80"><label>80</label><addr-line>Department of Human Genetics and Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands</addr-line></aff><aff id="aff81"><label>81</label><addr-line>Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands</addr-line></aff><aff id="aff82"><label>82</label><addr-line>Department of Human Genetics and Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands</addr-line></aff><aff id="aff83"><label>83</label><addr-line>The Hereditary Breast and Ovarian Cancer Research Group Netherlands, Netherlands Cancer Institute, Amsterdam, The Netherlands</addr-line></aff><aff id="aff84"><label>84</label><addr-line>Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom</addr-line></aff><aff id="aff85"><label>85</label><addr-line>Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom</addr-line></aff><aff id="aff86"><label>86</label><addr-line>Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom</addr-line></aff><aff id="aff87"><label>87</label><addr-line>Yorkshire Regional Genetics Service, Leeds, United Kingdom</addr-line></aff><aff id="aff88"><label>88</label><addr-line>University of Southampton Faculty of Medicine, Southampton University Hospitals NHS Trust, Southampton, United Kingdom</addr-line></aff><aff id="aff89"><label>89</label><addr-line>Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, United Kingdom</addr-line></aff><aff id="aff90"><label>90</label><addr-line>Department of Clinical Genetics, Royal Devon and Exeter Hospital, Exeter, United Kingdom</addr-line></aff><aff id="aff91"><label>91</label><addr-line>Institute of Genetic Medicine, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom</addr-line></aff><aff id="aff92"><label>92</label><addr-line>Department of Clinical Genetics, St George's University of London, London, United Kingdom</addr-line></aff><aff id="aff93"><label>93</label><addr-line>Northern Ireland Regional Genetics Centre, Belfast Health and Social Care Trust, and Department of Medical Genetics, Queens University Belfast, Belfast, United Kingdom</addr-line></aff><aff id="aff94"><label>94</label><addr-line>North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust and Institute for Womens Health, University College London, London, United Kingdom</addr-line></aff><aff id="aff95"><label>95</label><addr-line>Clinical Genetics Department, St Michael's Hospital, Bristol, United Kingdom</addr-line></aff><aff id="aff96"><label>96</label><addr-line>Cheshire and Merseyside Clinical Genetics Service, Liverpool Women's NHS Foundation Trust, Liverpool, United Kingdom</addr-line></aff><aff id="aff97"><label>97</label><addr-line>All Wales Medical Genetics Services, University Hospital of Wales, Cardiff, United Kingdom</addr-line></aff><aff id="aff98"><label>98</label><addr-line>North West Thames Regional Genetics Service, Kennedy-Galton Centre, Harrow, United Kingdom</addr-line></aff><aff id="aff99"><label>99</label><addr-line>Nottingham Clinical Genetics Service, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom</addr-line></aff><aff id="aff100"><label>100</label><addr-line>North of Scotland Regional Genetics Service, NHS Grampian and University of Aberdeen, Foresterhill, Aberdeen, United Kingdom</addr-line></aff><aff id="aff101"><label>101</label><addr-line>All Wales Medical Genetics Services, Glan Clwyd Hospital, Rhyl, United Kingdom</addr-line></aff><aff id="aff102"><label>102</label><addr-line>All Wales Medical Genetics Services, Singleton Hospital, Swansea, United Kingdom</addr-line></aff><aff id="aff103"><label>103</label><addr-line>Centre François Baclesse, Caen, France</addr-line></aff><aff id="aff104"><label>104</label><addr-line>Centre René Gauducheau, Nantes, France</addr-line></aff><aff id="aff105"><label>105</label><addr-line>Oncogénétique Clinique, Hôpital René Huguenin/Institut Curie, Saint-Cloud, France</addr-line></aff><aff id="aff106"><label>106</label><addr-line>Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France</addr-line></aff><aff id="aff107"><label>107</label><addr-line>Université Lyon 1, CNRS UMR5558, Lyon, France</addr-line></aff><aff id="aff108"><label>108</label><addr-line>Department of Genetics, Centre Hospitalier Universitaire de Grenoble, Grenoble, France</addr-line></aff><aff id="aff109"><label>109</label><addr-line>Institut Albert Bonniot, Université de Grenoble, Grenoble, France</addr-line></aff><aff id="aff110"><label>110</label><addr-line>Laboratoire d'Oncogénétique, Hôpital René Huguenin, Institut Curie, Saint-Cloud, France</addr-line></aff><aff id="aff111"><label>111</label><addr-line>Service de Génétique Clinique Chromosomique et Moléculaire, Centre Hospitalier Universitaire de St Etienne, St Etienne, France</addr-line></aff><aff id="aff112"><label>112</label><addr-line>Département Oncologie Génétique, Prévention et Dépistage, INSERM CIC-P9502, Institut Paoli-Calmettes/Université d'Aix-Marseille II, Marseille, France</addr-line></aff><aff id="aff113"><label>113</label><addr-line>Unité d'Oncogénétique, CHU Arnaud de Villeneuve, Montpellier, France</addr-line></aff><aff id="aff114"><label>114</label><addr-line>Unité d'Oncogénétique, CRLCC Val d'Aurelle, Montpellier, France</addr-line></aff><aff id="aff115"><label>115</label><addr-line>Department of Medical Oncology, Centre Hospitalier Universitaire Dupuytren, Limoges, France</addr-line></aff><aff id="aff116"><label>116</label><addr-line>INSERM 896, CRCM Val d'Aurelle, Montpellier, France</addr-line></aff><aff id="aff117"><label>117</label><addr-line>Département d'Oncogénétique, Centre Jean Perrin, Université de Clermont-Ferrand, Clermont-Ferrand, France</addr-line></aff><aff id="aff118"><label>118</label><addr-line>National Cancer Genetics Network, UNICANCER Genetic Group, Centre de Recherche en Cancérologie de Lyon and Institut Curie Paris, Paris, France</addr-line></aff><aff id="aff119"><label>119</label><addr-line>Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland</addr-line></aff><aff id="aff120"><label>120</label><addr-line>Division of Experimental Oncology 1, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy</addr-line></aff><aff id="aff121"><label>121</label><addr-line>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</addr-line></aff><aff id="aff122"><label>122</label><addr-line>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy</addr-line></aff><aff id="aff123"><label>123</label><addr-line>Department of Molecular Medicine, Sapienza University, Rome, Italy</addr-line></aff><aff id="aff124"><label>124</label><addr-line>Unit of Medical Genetics, Department of Clinical Physiopathology, University of Florence, Firenze, Italy</addr-line></aff><aff id="aff125"><label>125</label><addr-line>Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, IRCCS AOU San Martino–IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy</addr-line></aff><aff id="aff126"><label>126</label><addr-line>UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria, Varese, Italy</addr-line></aff><aff id="aff127"><label>127</label><addr-line>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare and Cogentech Cancer Genetic Test Laboratory, Milan, Italy</addr-line></aff><aff id="aff128"><label>128</label><addr-line>University Hospital of Schleswig-Holstein/University Kiel, Kiel, Germany</addr-line></aff><aff id="aff129"><label>129</label><addr-line>Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany</addr-line></aff><aff id="aff130"><label>130</label><addr-line>University Hospital Ulm, Ulm, Germany</addr-line></aff><aff id="aff131"><label>131</label><addr-line>Hannover Medical School, Hanover, Germany</addr-line></aff><aff id="aff132"><label>132</label><addr-line>Institute of Human Genetics, University of Würzburg, Wurzburg, Germany</addr-line></aff><aff id="aff133"><label>133</label><addr-line>Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany</addr-line></aff><aff id="aff134"><label>134</label><addr-line>Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany</addr-line></aff><aff id="aff135"><label>135</label><addr-line>Department of Obstetrics and Gynaecology, University Medical Center Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany</addr-line></aff><aff id="aff136"><label>136</label><addr-line>Department of Gynaecology and Obstetrics, University of Munich, Munich, Germany</addr-line></aff><aff id="aff137"><label>137</label><addr-line>Institute of Human Genetics, University Hospital of Schleswig-Holstein, University of Kiel, Kiel, Germany</addr-line></aff><aff id="aff138"><label>138</label><addr-line>Institute of Human Genetics, Münster, Germany</addr-line></aff><aff id="aff139"><label>139</label><addr-line>Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany</addr-line></aff><aff id="aff140"><label>140</label><addr-line>Institute of Medical and Human Genetics, Berlin, Germany</addr-line></aff><aff id="aff141"><label>141</label><addr-line>Institute of Human Genetics, University of Regensburg, Regensburg, Germany</addr-line></aff><aff id="aff142"><label>142</label><addr-line>Department of Oncology and Pathology, Karolinska University Hospital, Stockholm, Sweden</addr-line></aff><aff id="aff143"><label>143</label><addr-line>Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden</addr-line></aff><aff id="aff144"><label>144</label><addr-line>Department of Oncology, Lund University Hospital, Lund, Sweden</addr-line></aff><aff id="aff145"><label>145</label><addr-line>Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</addr-line></aff><aff id="aff146"><label>146</label><addr-line>Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden</addr-line></aff><aff id="aff147"><label>147</label><addr-line>Abramson Cancer Center and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America</addr-line></aff><aff id="aff148"><label>148</label><addr-line>Abramson Cancer Center and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America</addr-line></aff><aff id="aff149"><label>149</label><addr-line>NYU Women's Cancer Program, New York University School of Medicine, New York, New York, United States of America</addr-line></aff><aff id="aff150"><label>150</label><addr-line>Ohio State University, Columbus Cancer Council, Columbus, Ohio, United States of America</addr-line></aff><aff id="aff151"><label>151</label><addr-line>Division of Gynecologic Oncology, North Shore University Health System, University of Chicago, Evanston, Illinois, United States of America</addr-line></aff><aff id="aff152"><label>152</label><addr-line>Maine Medical Center, Maine Women's Surgery and Cancer Centre, Scarborough, Maine, United States of America</addr-line></aff><aff id="aff153"><label>153</label><addr-line>ANZ GOTG Coordinating Centre, Australia New Zealand GOG, Camperdown, Australia</addr-line></aff><aff id="aff154"><label>154</label><addr-line>The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America</addr-line></aff><aff id="aff155"><label>155</label><addr-line>Department of Health Science Research, Mayo Clinic Arizona, Scottsdale, Arizona, United States of America</addr-line></aff><aff id="aff156"><label>156</label><addr-line>Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark</addr-line></aff><aff id="aff157"><label>157</label><addr-line>Department of Clincial Genetics, Rigshospitalet, København, Denmark</addr-line></aff><aff id="aff158"><label>158</label><addr-line>Section of Molecular Diagnostics, Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark</addr-line></aff><aff id="aff159"><label>159</label><addr-line>Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark</addr-line></aff><aff id="aff160"><label>160</label><addr-line>Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America</addr-line></aff><aff id="aff161"><label>161</label><addr-line>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada</addr-line></aff><aff id="aff162"><label>162</label><addr-line>Department of Laboratory Medicine, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Canada</addr-line></aff><aff id="aff163"><label>163</label><addr-line>Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</addr-line></aff><aff id="aff164"><label>164</label><addr-line>Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</addr-line></aff><aff id="aff165"><label>165</label><addr-line>Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic</addr-line></aff><aff id="aff166"><label>166</label><addr-line>Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL–Catalan Institute of Oncology, Barcelona, Spain</addr-line></aff><aff id="aff167"><label>167</label><addr-line>Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI–Catalan Institute of Oncology, Girona, Spain</addr-line></aff><aff id="aff168"><label>168</label><addr-line>Translational Research Laboratory, Breast Cancer and Systems Biology Unit, IDIBELL–Catalan Institute of Oncology, Barcelona, Spain</addr-line></aff><aff id="aff169"><label>169</label><addr-line>Women's College Research Institute, University of Toronto, Toronto, Canada</addr-line></aff><aff id="aff170"><label>170</label><addr-line>Biosample Repository, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America</addr-line></aff><aff id="aff171"><label>171</label><addr-line>Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America</addr-line></aff><aff id="aff172"><label>172</label><addr-line>Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</addr-line></aff><aff id="aff173"><label>173</label><addr-line>Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM–UVA), Valladolid, Spain</addr-line></aff><aff id="aff174"><label>174</label><addr-line>Departments of Pediatrics and Medicine, Columbia University, New York, New York, United States of America</addr-line></aff><aff id="aff175"><label>175</label><addr-line>Genetics Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain</addr-line></aff><aff id="aff176"><label>176</label><addr-line>Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America</addr-line></aff><aff id="aff177"><label>177</label><addr-line>Breast Cancer Family Registry, Cancer Prevention Institute of California, Fremont, California, United States of America</addr-line></aff><aff id="aff178"><label>178</label><addr-line>Human Genetics Group and Genotyping Unit, Spanish National Cancer Centre (CNIO), and Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</addr-line></aff><aff id="aff179"><label>179</label><addr-line>Divison of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America</addr-line></aff><aff id="aff180"><label>180</label><addr-line>Cancer Risk Program, Helen Diller Family Cancer Center, University of California San Francisco, San Francisco, California, United States of America</addr-line></aff><aff id="aff181"><label>181</label><addr-line>Unité de Recherche en Santé des Populations, Centre des Maladies du Sein Deschênes-Fabia, Centre de Recherche FRSQ du Centre Hospitalier Affilié Universitaire de Québec, Québec, Canada</addr-line></aff><aff id="aff182"><label>182</label><addr-line>Latvian Biomedical Research and Study Centre, Riga, Latvia</addr-line></aff><aff id="aff183"><label>183</label><addr-line>University of Pennsylvania, Philadelphia, Pennsylvania, United States of America</addr-line></aff><aff id="aff184"><label>184</label><addr-line>Landspitali University Hospital and University of Iceland School of Medicine, Reykjavik, Iceland</addr-line></aff><aff id="aff185"><label>185</label><addr-line>Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel</addr-line></aff><aff id="aff186"><label>186</label><addr-line>Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Australia</addr-line></aff><aff id="aff187"><label>187</label><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line></aff><aff id="aff188"><label>188</label><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line></aff><aff id="aff189"><label>189</label><addr-line>Department of Human Genetics, McGill University and Génome Québec Innovation Centre, McGill University, Montréal, Canada</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Hunter</surname><given-names>Kent W.</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>National Cancer Institute, United States of America</addr-line></aff><author-notes><corresp id="cor1">* E-mail: <email>couch.fergus@mayo.edu</email> (Fergus J Couch); <email>Antonis@srl.cam.ac.uk</email> (Antonis C Antoniou)</corresp><fn fn-type="COI-statement"><p>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con"><p>Conceived and designed the experiments: Fergus J Couch, Douglas F Easton, Georgia Chenevix-Trench, Kenneth Offit, Antonis C Antoniou. Performed the experiments: Fergus J Couch, Julie Cunningham, Xianshu Wang, Curtis Olswold, Matthew Kosel, Adam Lee, Mia M Gaudet, Kenneth Offit, François Bacot, Daniel Vincent, Daniel Tessier. Analyzed the data: Antonis C Antoniou, Karoline B Kuchenbaecker, Lesley McGuffog, Daniel Barrowdale, Andrew Lee, Joe Dennis, Ed Dicks, Vernon S Pankratz, Zachary Fredericksen, Curtis Olswold, Matthew Kosel. Contributed reagents/materials/analysis tools: Penny Soucy, Kristen Stevens, Jacques Simard, Tomi Pastinen, Sue Healey, Olga M Sinilnikova, Andrew Lee. Wrote the manuscript: Fergus J Couch, Douglas F Easton, Antonis C Antoniou. Collected data and samples and provided critical review of the manuscript: Fergus J Couch, Xianshu Wang, Lesley McGuffog, Curtis Olswold, Karoline B Kuchenbaecker, Penny Soucy, Zachary Fredericksen, Daniel Barrowdale, Joe Dennis, Mia M Gaudet, Ed Dicks, Matthew Kosel, Olga M Sinilnikova, François Bacot, Daniel Vincent, Frans BL Hogervorst, Susan Peock, Dominique Stoppa-Lyonnet, Anna Jakubowska, Paolo Radice, Rita Katharina Schmutzler, Susan M Domchek, Marion Piedmonte, Christian F Singer, Thomas v O Hansen, Susan L Neuhausen, Csilla I Szabo, Ignacio Blanco, Mark H Greene, Beth Y Karlan, Catherine M Phelan, Jeffrey N Weitzel, Marco Montagna, Edith Olah, Irene L Andrulis, Andrew K Godwin, Drakoulis Yannoukakos, David E Goldgar, Trinidad Caldes, Heli Nevanlinna, Ana Osorio, Mary Beth Terry, Mary B Daly, Elizabeth J van Rensburg, Ute Hamann, Susan J Ramus, Amanda Ewart Toland, Maria A Caligo, Olufunmilayo I Olopade, Nadine Tung, Kathleen Claes, Mary S Beattie, Melissa C Southey, Evgeny N Imyanitov, Ramunas Janavicius, Esther M John, Ava Kwong, Orland Diez, Rosa B Barkardottir, Banu K Arun, Gad Rennert, Soo-Hwang Teo, Patricia A Ganz, Annemarie H van der Hout, Carolien HM van Deurzen, Encarna B Gómez Garcia, Flora E van Leeuwen, Hanne EJ Meijers-Heijboer, Johannes JP Gille, Margreet GEM Ausems, Marinus J Blok, Marjolijn JL Ligtenberg, Matti A Rookus, Peter Devilee, Theo AM van Os, Juul T Wijnen, Debra Frost, Radka Platte, D Gareth Evans, Louise Izatt, Rosalind A Eeles, Julian Adlard, Diana M Eccles, Carole Brewer, Patrick J Morrison, Lucy E Side, Alan Donaldson, Mark T Rogers, Jacqueline Eason, Helen Gregory, Emma McCann, Alain Calender, Agnès Hardouin, Pascaline Berthet, Capucine Delnatte, Catherine Nogues, Dominique Leroux, Etienne Rouleau, Fabienne Prieur, Hagay Sobol, Laurence Venat-Bouvet, Laurent Castera, Marion Gauthier-Villars, Mélanie Léoné, Yves-Jean Bignon, Elżbieta Złowocka-Perłowska, Katarzyna Durda, Katarzyna Jaworska, Tomasz Huzarski, Alessandra Viel, Bernard Peissel, Bernardo Bonanni, Giulia Melloni, Laura Ottini, Laura Papi, Liliana Varesco, Maria Grazia Tibiletti, Valeria Pensotti, Norbert Arnold, Christoph Engel, Dorothea Gadzicki, Andrea Gehrig, Karin Kast, Kerstin Rhiem, Dieter Niederacher, Nina Ditsch, Hansjoerg Plendl, Sabine Preisler-Adams, Raymonda Varon-Mateeva, Barbara Wappenschmidt, Bernhard H F Weber, Brita Arver, Marie Stenmark-Askmalm, Richard Rosenquist, Zakaria Einbeigi, Katherine L Nathanson, Timothy R Rebbeck, Stephanie V Blank, David E Cohn, Gustavo C Rodriguez, Michael Friedlander, Victoria L Bae-Jump, Anneliese Fink-Retter, Christine Rappaport, Daphne Gschwantler Kaulich, Georg Pfeiler, Muy-Kheng Tea, Bella Kaufman, Shani Shimon Paluch, Yael Laitman, Anne-Marie Gerdes, Inge Sokilde Pedersen, Sanne Traasdahl Moeller, Torben A Kruse, Uffe Birk Jensen, Joseph Vijai, Mark Robson, Noah Kauff, Anna Marie Mulligan, Gord Glendon, Hilmi Ozcelik, Bent Ejlertsen, Finn C Nielsen, Lars Jønson, Mette K Andersen, Yuan Chun Ding, Lenka Foretova, Alex Teulé, Miquel Angel Pujana, Phuong L Mai, Jennifer T Loud, Sandra Orsulic, Steven A Narod, Josef Herzog, Sharon R Sand, Silvia Tognazzo, Simona Agata, Tibor Vaszko, Joellen Weaver, Alexandra V Stavropoulou, Saundra S Buys, Atocha Romero, Miguel de la Hoya, Kristiina Aittomäki, Taru A Muranen, Mercedes Duran, Wendy K Chung, Cecilia M Dorfling, Dezheng Huo, Salina B Chan, Anna P Sokolenko, Laima Tihomirova, Tara M Friebel, Bjarni A Agnarsson, Karen H Lu, Flavio Lejbkowicz, Paul A James, Per Hall, Alison M Dunning, Daniel Tessier, Susan L Slager, Jacques Simard, Tomi Pastinen, Vernon S Pankratz, Kenneth Offit, Douglas F Easton, Georgia Chenevix-Trench, Antonis C Antoniou, Andrew Lee, Adam Lee, Adriana Lasa, Alexander Miron, Caroline Seynaeve, Christian Sutter, Eitan Friedman, Elena Fineberg, Christine Lasset, Amanda B Spurdle, Anne-Bine Skytte, Alfons Meindl, Claude Houdayer, Fiona Douglas Francesca Damiola, Catherine Houghton, Alex Murray, Jan Lubinski, Conxi Lazaro, Christine Walsh, Chen Wang, Jenny Lester, Huw Dorkins, Helmut Deissler, Ian Campbell, Isabelle Coupier, Judith Balmaña, Joan Brunet, Javier Benitez, Jackie Cook, Jocelyne Chiquette, Judy Garber, Jacek Gronwald, Kara Sarrel, Kristen Stevens, Laurie Small, Leigha Senter, Linda Steele, Mads Thomassen, Marc Tischkowitz, Niklas Loman, Noralane M Lindor, Pascal Pujol, Paolo Peterlongo, Steve Ellis, Stefanie Engert, Sue Healey, Shirley Hodgson, Steven Hart, Sylvie Mazoyer, Siranoush, Manoukian, Senno Verhoef, Sara Volorio.</p></fn></author-notes><pub-date pub-type="collection"><month>3</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>27</day><month>3</month><year>2013</year></pub-date><volume>9</volume><issue>3</issue><elocation-id>e1003212</elocation-id><history><date date-type="received"><day>7</day><month>9</month><year>2012</year></date><date date-type="accepted"><day>14</day><month>11</month><year>2012</year></date></history><permissions><copyright-statement>© 2013 Couch et al</copyright-statement><copyright-year>2013</copyright-year><copyright-holder>Couch et al</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.</license-p></license></permissions><related-article id="RA1" related-article-type="companion" vol="" page="e1003173" ext-link-type="pmc"><pmc-comment>related-article was converted to @ext-link-type="pmc" and original @xlink:href value
was info:doi/10.1371/journal.pgen.1003173</pmc-comment>
<article-title>Identification of a BRCA2-specific Modifier Locus at 6p24 Related to Breast Cancer Risk</article-title></related-article><related-article id="RA2" related-article-type="companion" vol="" page="e1003284" ext-link-type="pmc"><pmc-comment>related-article was converted to @ext-link-type="pmc" and original @xlink:href value
was info:doi/10.1371/journal.pgen.1003284</pmc-comment>
<article-title>Evidence of Gene-Environment Interactions between Common Breast Cancer Susceptibility Loci and Established Environmental Risk Factors</article-title></related-article><abstract><p><italic>BRCA1</italic>-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 <italic>BRCA1</italic> carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 <italic>BRCA1</italic> carriers. We identified a novel breast cancer risk modifier locus at 1q32 for <italic>BRCA1</italic> carriers (rs2290854, P = 2.7×10<sup>−8</sup>, HR = 1.14, 95% CI: 1.09–1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10<sup>−8</sup>, HR = 1.27, 95% CI: 1.17–1.38) and 4q32.3 (rs4691139, P = 3.4×10<sup>−8</sup>, HR = 1.20, 95% CI: 1.17–1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or <italic>BRCA2</italic> carriers, suggesting a <italic>BRCA1</italic>-specific association. The 17q21.31 locus was also associated with ovarian cancer risk in 8,211 <italic>BRCA2</italic> carriers (P = 2×10<sup>−4</sup>). These loci may lead to an improved understanding of the etiology of breast and ovarian tumors in <italic>BRCA1</italic> carriers. Based on the joint distribution of the known <italic>BRCA1</italic> breast cancer risk-modifying loci, we estimated that the breast cancer lifetime risks for the 5% of <italic>BRCA1</italic> carriers at lowest risk are 28%–50% compared to 81%–100% for the 5% at highest risk. Similarly, based on the known ovarian cancer risk-modifying loci, the 5% of <italic>BRCA1</italic> carriers at lowest risk have an estimated lifetime risk of developing ovarian cancer of 28% or lower, whereas the 5% at highest risk will have a risk of 63% or higher. Such differences in risk may have important implications for risk prediction and clinical management for <italic>BRCA1</italic> carriers.</p></abstract><abstract abstract-type="summary"><title>Author Summary</title><p><italic>BRCA1</italic> mutation carriers have increased and variable risks of breast and ovarian cancer. To identify modifiers of breast and ovarian cancer risk in this population, a multi-stage GWAS of 14,351 <italic>BRCA1</italic> mutation carriers was performed. Loci 1q32 and <italic>TCF7L2</italic> at 10q25.3 were associated with breast cancer risk, and two loci at 4q32.2 and 17q21.31 were associated with ovarian cancer risk. The 4q32.3 ovarian cancer locus was not associated with ovarian cancer risk in the general population or in <italic>BRCA2</italic> carriers and is the first indication of a <italic>BRCA1</italic>-specific risk locus for either breast or ovarian cancer. Furthermore, modeling the influence of these modifiers on cumulative risk of breast and ovarian cancer in <italic>BRCA1</italic> mutation carriers for the first time showed that a wide range of individual absolute risks of each cancer can be estimated. These differences suggest that genetic risk modifiers may be incorporated into the clinical management of <italic>BRCA1</italic> mutation carriers.</p></abstract><funding-group><funding-statement>The study was supported by NIH grant CA128978, an NCI Specialized Program of Research Excellence (SPORE) in Breast Cancer (CA116201), a U.S. Department of Defense Ovarian Cancer Idea award (W81XWH-10-1-0341), grants from the Breast Cancer Research Foundation and the Komen Foundation for the Cure; Cancer Research UK grants C12292/A11174 and C1287/A10118; the European Commission's Seventh Framework Programme grant agreement 223175 (HEALTH-F2-2009-223175). Breast Cancer Family Registry Studies (BCFR): supported by the National Cancer Institute, National Institutes of Health under RFA # CA-06-503 and through cooperative agreements with members of the Breast Cancer Family Registry (BCFR) and Principal Investigators, including Cancer Care Ontario (U01 CA69467), Cancer Prevention Institute of California (U01 CA69417), Columbia University (U01 CA69398), Fox Chase Cancer Center (U01 CA69631), Huntsman Cancer Institute (U01 CA69446), and University of Melbourne (U01 CA69638). The Australian BCFR was also supported by the National Health and Medical Research Council of Australia, the New South Wales Cancer Council, the Victorian Health Promotion Foundation (Australia), and the Victorian Breast Cancer Research Consortium. Melissa C. Southey is a NHMRC Senior Research Fellow and a Victorian Breast Cancer Research Consortium Group Leader. Carriers at FCCC were also identified with support from National Institutes of Health grants P01 CA16094 and R01 CA22435. The New York BCFR was also supported by National Institutes of Health grants P30 CA13696 and P30 ES009089. The Utah BCFR was also supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences, NIH grant UL1 RR025764, and by Award Number P30 CA042014 from the National Cancer Institute. Baltic Familial Breast Ovarian Cancer Consortium (BFBOCC): BFBOCC is partly supported by Lithuania (BFBOCC-LT), Research Council of Lithuania grant LIG-19/2010, and Hereditary Cancer Association (Paveldimo vėžio asociacija). Latvia (BFBOCC-LV) is partly supported by LSC grant 10.0010.08 and in part by a grant from the ESF Nr.2009/0220/1DP/1.1.1.2.0/09/APIA/VIAA/016. BRCA-gene mutations and breast cancer in South African women (BMBSA): BMBSA was supported by grants from the Cancer Association of South Africa (CANSA) to Elizabeth J. van Rensburg. Beckman Research Institute of the City of Hope (BRICOH): Susan L. Neuhausen was partially supported by the Morris and Horowitz Families Endowed Professorship. BRICOH was supported by NIH R01CA74415 and NIH P30 CA033752. Copenhagen Breast Cancer Study (CBCS): The CBCS study was supported by the NEYE Foundation. Spanish National Cancer Centre (CNIO): This work was partially supported by Spanish Association against Cancer (AECC08), RTICC 06/0020/1060, FISPI08/1120, Mutua Madrileña Foundation (FMMA) and SAF2010-20493. City of Hope Cancer Center (COH): The City of Hope Clinical Cancer Genetics Community Research Network is supported by Award Number RC4A153828 (PI: Jeffrey N. Weitzel) from the National Cancer Institute and the Office of the Director, National Institutes of Health. CONsorzio Studi ITaliani sui Tumori Ereditari Alla Mammella (CONSIT TEAM): CONSIT TEAM was funded by grants from Fondazione Italiana per la Ricerca sul Cancro (Special Project “Hereditary tumors”), Italian Association for Cancer Research (AIRC, IG 8713), Italian Minitry of Health (Extraordinary National Cancer Program 2006, “Alleanza contro il Cancro” and “Progetto Tumori Femminili), Italian Ministry of Education, University and Research (Prin 2008) Centro di Ascolto Donne Operate al Seno (CAOS) association and by funds from Italian citizens who allocated the 5×1000 share of their tax payment in support of the Fondazione IRCCS Istituto Nazionale Tumori, according to Italian laws (INT-Institutional strategic projects ‘5×1000’). German Cancer Research Center (DKFZ): The DKFZ study was supported by the DKFZ. The Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON): HEBON is supported by the Dutch Cancer Society grants NKI1998-1854, NKI2004-3088, NKI2007-3756, the NWO grant 91109024, the Pink Ribbon grant 110005, and the BBMRI grant CP46/NWO. Epidemiological study of BRCA1 & BRCA2 mutation carriers (EMBRACE): EMBRACE is supported by Cancer Research UK Grants C1287/A10118 and C1287/A11990. D. Gareth Evans and Fiona Lalloo are supported by an NIHR grant to the Biomedical Research Centre, Manchester. The Investigators at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust are supported by an NIHR grant to the Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. Rosalind A. Eeles and Elizabeth Bancroft are supported by Cancer Research UK Grant C5047/A8385. Fox Chase Cancer Canter (FCCC): The authors acknowledge support from The University of Kansas Cancer Center and the Kansas Bioscience Authority Eminent Scholar Program. Andrew K. Godwin was funded by 5U01CA113916, R01CA140323, and by the Chancellors Distinguished Chair in Biomedical Sciences Professorship. German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC): The German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC) is supported by the German Cancer Aid (grant no 109076, Rita K. Schmutzler) and by the Center for Molecular Medicine Cologne (CMMC). Genetic Modifiers of cancer risk in BRCA1/2 mutation carriers (GEMO): The GEMO study was supported by the Ligue National Contre le Cancer; the Association “Le cancer du sein, parlons-en!” Award and the Canadian Institutes of Health Research for the “CIHR Team in Familial Risks of Breast Cancer” program. Gynecologic Oncology Group (GOG): This study was supported by National Cancer Institute grants to the Gynecologic Oncology Group (GOG) Administrative Office and Tissue Bank (CA 27469), Statistical and Data Center (CA 37517), and GOG's Cancer Prevention and Control Committtee (CA 101165). Drs. Mark H. Greene and Phuong L. Mai were supported by funding from the Intramural Research Program, NCI, NIH. Hospital Clinico San Carlos (HCSC): HCSC was supported by RETICC 06/0020/0021, FIS research grant 09/00859, Instituto de Salud Carlos III, Spanish Ministry of Economy and Competitivity, and the European Regional Development Fund (ERDF). Helsinki Breast Cancer Study (HEBCS): The HEBCS was financially supported by the Helsinki University Central Hospital Research Fund, Academy of Finland (132473), the Finnish Cancer Society, the Nordic Cancer Union, and the Sigrid Juselius Foundation. Study of Genetic Mutations in Breast and Ovarian Cancer patients in Hong Kong and Asia (HRBCP): HRBCP is supported by The Hong Kong Hereditary Breast Cancer Family Registry and the Dr. Ellen Li Charitable Foundation, Hong Kong. Molecular Genetic Studies of Breast and Ovarian Cancer in Hungary (HUNBOCS): HUNBOCS was supported by Hungarian Research Grant KTIA-OTKA CK-80745 and the Norwegian EEA Financial Mechanism HU0115/NA/2008-3/ÖP-9. Institut Català d'Oncologia (ICO): The ICO study was supported by the Asociación Española Contra el Cáncer, Spanish Health Research Foundation, Ramón Areces Foundation, Carlos III Health Institute, Catalan Health Institute, and Autonomous Government of Catalonia and contract grant numbers: ISCIIIRETIC RD06/0020/1051, PI09/02483, PI10/01422, PI10/00748, 2009SGR290, and 2009SGR283. International Hereditary Cancer Centre (IHCC): Supported by the Polish Foundation of Science. Katarzyna Jaworska is a fellow of International PhD program, Postgraduate School of Molecular Medicine, Warsaw Medical University. Iceland Landspitali–University Hospital (ILUH): The ILUH group was supported by the Icelandic Association “Walking for Breast Cancer Research” and by the Landspitali University Hospital Research Fund. INterdisciplinary HEalth Research Internal Team BReast CAncer susceptibility (INHERIT): INHERIT work was supported by the Canadian Institutes of Health Research for the “CIHR Team in Familial Risks of Breast Cancer” program, the Canadian Breast Cancer Research Alliance grant 019511 and the Ministry of Economic Development, Innovation and Export Trade grant PSR-SIIRI-701. Jacques Simard is Chairholder of the Canada Research Chair in Oncogenetics. Istituto Oncologico Veneto (IOVHBOCS): The IOVHBOCS study was supported by Ministero dell'Istruzione, dell'Università e della Ricerca and Ministero della Salute (“Progetto Tumori Femminili” and RFPS 2006-5-341353,ACC2/R6.9”). Kathleen Cuningham Consortium for Research into Familial Breast Cancer (kConFab): kConFab is supported by grants from the National Breast Cancer Foundation and the National Health and Medical Research Council (NHMRC) and by the Queensland Cancer Fund; the Cancer Councils of New South Wales, Victoria, Tasmania, and South Australia; and the Cancer Foundation of Western Australia. Amanda B. Spurdle is an NHMRC Senior Research Fellow. The Clinical Follow Up Study was funded from 2001–2009 by NHMRC and currently by the National Breast Cancer Foundation and Cancer Australia #628333. Mayo Clinic (MAYO): MAYO is supported by NIH grant CA128978, an NCI Specialized Program of Research Excellence (SPORE) in Breast Cancer (CA116201), a U.S. Department of Defence Ovarian Cancer Idea award (W81XWH-10-1-0341) and grants from the Breast Cancer Research Foundation and the Komen Foundation for the Cure. McGill University (MCGILL): The McGill Study was supported by Jewish General Hospital Weekend to End Breast Cancer, Quebec Ministry of Economic Development, Innovation, and Export Trade. Memorial Sloan-Kettering Cancer Center (MSKCC): The MSKCC study was supported by Breast Cancer Research Foundation, Niehaus Clinical Cancer
Genetics Initiative, Andrew Sabin Family Foundation, and Lymphoma Foundation. Modifier Study of Quantitative Effects on Disease (MODSQUAD): MODSQUAD was supported by the European Regional Development Fund and the State Budget of the Czech Republic (RECAMO, CZ.1.05/2.1.00/03.0101). Women's College Research Institute, Toronto (NAROD): NAROD was supported by NIH grant: 1R01 CA149429-01. National Cancer Institute (NCI): Drs. Mark H. Greene and Phuong L. Mai were supported by the Intramural Research Program of the US National Cancer Institute, NIH, and by support services contracts NO2-CP-11019-50 and N02-CP-65504 with Westat, Rockville, MD. National Israeli Cancer Control Center (NICCC): NICCC is supported by Clalit Health Services in Israel. Some of its activities are supported by the Israel Cancer Association and the Breast Cancer Research Foundation (BCRF), NY. N. N. Petrov Institute of Oncology (NNPIO): The NNPIO study has been supported by the Russian Foundation for Basic Research (grants 11-04-00227, 12-04-00928, and 12-04-01490), the Federal Agency for Science and Innovations, Russia (contract 02.740.11.0780), and through a Royal Society International Joint grant (JP090615). The Ohio State University Comprehensive Cancer Center (OSU-CCG): OSUCCG is supported by the Ohio State University Comprehensive Cancer Center. South East Asian Breast Cancer Association Study (SEABASS): SEABASS is supported by the Ministry of Science, Technology and Innovation, Ministry of Higher Education (UM.C/HlR/MOHE/06) and Cancer Research Initiatives Foundation. Sheba Medical Centre (SMC): The SMC study was partially funded through a grant by the Israel Cancer Association and the funding for the Israeli Inherited Breast Cancer Consortium. Swedish Breast Cancer Study (SWE-BRCA): SWE-BRCA collaborators are supported by the Swedish Cancer Society. The University of Chicago Center for Clinical Cancer Genetics and Global Health (UCHICAGO): UCHICAGO is supported by grants from the US National Cancer Institute (NIH/NCI) and by the Ralph and Marion Falk Medical Research Trust, the Entertainment Industry Fund National Women's Cancer Research Alliance, and the Breast Cancer Research Foundation. University of California Los Angeles (UCLA): The UCLA study was supported by the Jonsson Comprehensive Cancer Center Foundation and the Breast Cancer Research Foundation. University of California San Francisco (UCSF): The UCSF study was supported by the UCSF Cancer Risk Program and the Helen Diller Family Comprehensive Cancer Center. United Kingdom Familial Ovarian Cancer Registries (UKFOCR): UKFOCR was supported by a project grant from CRUK to Paul Pharoah. University of Pennsylvania (UPENN): The UPENN study was supported by the National Institutes of Health (NIH) (R01-CA102776 and R01-CA083855), Breast Cancer Research Foundation, Rooney Family Foundation, Susan G. Komen Foundation for the Cure, and the Macdonald Family Foundation. Victorian Familial Cancer Trials Group (VFCTG): The VFCTG study was supported by the Victorian Cancer Agency, Cancer Australia, and National Breast Cancer Foundation. Women's Cancer Research Initiative (WCRI): The WCRI at the Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, is funded by the American Cancer Society Early Detection Professorship (SIOP-06-258-01-COUN). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><page-count count="21"></page-count></counts></article-meta></front><body><sec id="s1"><title>Introduction</title><p>Breast and ovarian cancer risk estimates for <italic>BRCA1</italic> mutation carriers vary by the degree of family history of the disease, suggesting that other genetic factors modify cancer risks for this population <xref rid="pgen.1003212-Antoniou1" ref-type="bibr">[1]</xref>–<xref rid="pgen.1003212-Simchoni1" ref-type="bibr">[4]</xref>. Studies by the Consortium of Investigators of Modifiers of <italic>BRCA1/2</italic> (CIMBA) have shown that a subset of common alleles influencing breast and ovarian cancer risk in the general population are also associated with cancer risk in <italic>BRCA1</italic> mutation carriers <xref rid="pgen.1003212-Couch1" ref-type="bibr">[5]</xref>–<xref rid="pgen.1003212-Antoniou6" ref-type="bibr">[11]</xref>. In particular, the breast cancer associations were limited to loci associated with estrogen receptor (ER)-negative breast cancer in the general population (6q25.1, 12p11 and <italic>TOX3</italic>) <xref rid="pgen.1003212-Antoniou3" ref-type="bibr">[8]</xref>–<xref rid="pgen.1003212-Antoniou6" ref-type="bibr">[11]</xref>.</p><p>To systematically search for loci associated with breast or ovarian cancer risk for <italic>BRCA1</italic> carriers we previously conducted a two-stage genome-wide association study (GWAS) <xref rid="pgen.1003212-Antoniou7" ref-type="bibr">[12]</xref>. The initial stage involved analysis of 555,616 SNPs in 2383 <italic>BRCA1</italic> mutation carriers (1,193 unaffected and 1,190 affected). After replication testing of 89 SNPs showing the strongest association, with 5,986 <italic>BRCA1</italic> mutation carriers, a locus on 19p13 was shown to be associated with breast cancer risk for <italic>BRCA1</italic> mutation carriers. The same locus was also associated with the risk of estrogen-receptor (ER) negative and triple negative (ER, Progesterone and HER2 negative) breast cancer in the general population <xref rid="pgen.1003212-Antoniou7" ref-type="bibr">[12]</xref>, <xref rid="pgen.1003212-Stevens1" ref-type="bibr">[13]</xref>.</p><p>The Collaborative Oncological Gene-environment Study (COGS) consortium recently developed a 211,155 SNP custom genotyping array (iCOGS) in order to provide cost-effective genotyping of common and rare genetic variants to identify novel loci that explain the residual genetic variance of breast, ovarian and prostate cancers and fine-map known susceptibility loci. A total of 32,557 SNPs on the iCOGS array were selected on the basis of the <italic>BRCA1</italic> GWAS for the purpose of identifying breast and ovarian cancer risk modifiers for <italic>BRCA1</italic> mutation carriers. Genotype data from the iCOGS array were obtained for 11,705 samples from <italic>BRCA1</italic> carriers and the 17 most promising SNPs were then genotyped in an additional 2,646 <italic>BRCA1</italic> carriers. In this manuscript we report on the novel risk modifier loci identified by this multi-stage GWAS. No study has previously shown how the absolute risks of breast and ovarian cancer for <italic>BRCA1</italic> mutation carriers vary by the combined effects of risk modifying loci. Here we use the results from this study, in combination with previously identified modifiers, to obtain absolute risks of developing breast and ovarian cancer for <italic>BRCA1</italic> mutation carriers based on the joint distribution of all known genetic risk modifiers.</p></sec><sec sec-type="materials|methods" id="s2"><title>Materials and Methods</title><sec id="s2a"><title>Ethics statement</title><p>All carriers participated in clinical or research studies at the host institutions, approved by local ethics committees.</p></sec><sec id="s2b"><title>Study subjects</title><p><italic>BRCA1</italic> mutation carriers were recruited by 45 study centers in 25 countries through CIMBA. The majority were recruited through cancer genetics clinics, and enrolled into national or regional studies. The remainder were identified by population-based sampling or community recruitment. Eligibility for CIMBA association studies was restricted to female carriers of pathogenic <italic>BRCA1</italic> mutations age 18 years or older at recruitment. Information collected included year of birth, mutation description, self-reported ethnic ancestry, age at last follow-up, ages at breast or ovarian cancer diagnoses, and age at bilateral prophylactic mastectomy and oophorectomy. Information on tumour characteristics, including ER-status of the breast cancers, was also collected. Related individuals were identified through a unique family identifier. Women were included in the analysis if they carried mutations that were pathogenic according to generally recognized criteria.</p><sec id="s2b1"><title>GWAS stage 1 samples</title><p>A total of 2,727 <italic>BRCA1</italic> mutation carriers were genotyped on the Illumina Infinium 610K array (<xref ref-type="fig" rid="pgen-1003212-g001">Figure 1</xref>). Of these 1,426 diagnosed with a first breast cancer under age 40 were considered “affected” in the breast cancer association analysis and 683 diagnosed with an ovarian cancer at any time were considered as “affected” in the ovarian cancer analysis. “Unaffected” in both analyses were over age 35 (<xref ref-type="supplementary-material" rid="pgen.1003212.s013">Table S1</xref>) <xref rid="pgen.1003212-Antoniou7" ref-type="bibr">[12]</xref>.</p><fig id="pgen-1003212-g001" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pgen.1003212.g001</object-id><label>Figure 1</label><caption><title>Study design for selection of the SNPs and genotyping of <italic>BRCA1</italic> samples.</title><p>GWAS data from 2,727 <italic>BRCA1</italic> mutation carriers were analysed for associations with breast and ovarian cancer risk and 32,557 SNPs were selected for inclusion on the iCOGS array. A total of 11,705 <italic>BRCA1</italic> samples (after quality control (QC) checks) were genotyped on the 31,812 <italic>BRCA1</italic>-GWAS SNPs from the iCOGS array that passed QC. Of these samples, 2,387 had been genotyped at the SNP selection stage and are referred to as “stage 1” samples, whereas 9,318 samples were unique to the iCOGS study (“Stage 2” samples). Next, 17 SNPs that exhibited the most significant associations with breast and ovarian cancer were selected for genotyping in a third stage involving an additional 2,646 <italic>BRCA1</italic> samples (after QC).</p></caption><graphic xlink:href="pgen.1003212.g001"></graphic></fig></sec><sec id="s2b2"><title>Replication study samples</title><p>All eligible <italic>BRCA1</italic> carriers from CIMBA with sufficient DNA were genotyped, including those used in Stage 1. In total, 13,310 samples from 45 centers in 25 countries were genotyped using the iCOGS array (<xref ref-type="supplementary-material" rid="pgen.1003212.s014">Table S2</xref>). Among the 13,310 samples, those that were genotyped in the GWAS stage 1 SNP selection stage are referred to as “stage 1” samples, and the remainder are “stage 2” samples. An additional 2,646 <italic>BRCA1</italic> samples “stage 3” were genotyped on an iPLEX Mass Array of 17 SNPs from 12 loci selected after an interim analysis of iCOGS array data and were available for analysis after quality control (QC) (<xref ref-type="fig" rid="pgen-1003212-g001">Figure 1</xref>). Carriers of pathogenic mutations in <italic>BRCA2</italic> were drawn from a parallel GWAS of genetic modifiers for <italic>BRCA2</italic> mutation carriers. <italic>BRCA2</italic> mutation carriers were recruited from CIMBA through 47 studies which were largely the same as the studies that contributed to the <italic>BRCA1</italic> GWAS with similar eligibility criteria. Samples from <italic>BRCA2</italic> mutation carriers were also genotyped using the iCOGS array. Details of this experiment are described elsewhere <xref rid="pgen.1003212-Gaudet1" ref-type="bibr">[14]</xref>. A total of 8,211 samples were available for analysis after QC.</p></sec></sec><sec id="s2c"><title>iCOGS SNP array</title><p>The iCOGS array was designed in a collaboration among the Breast Cancer Association Consortium (BCAC), Ovarian Cancer Association Consortium (OCAC), the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) and CIMBA. The general aims for designing the iCOGS array were to replicate findings from GWAS for identifying variants associated with breast, ovarian or prostate cancer (including subtypes and SNPs potentially associated with disease outcome), to facilitate fine-mapping of regions of interest, and to genotype “candidate” SNPs of interest within the consortia, including rarer variants. Each consortium was given a share of the array: nominally 25% of the SNPs each for BCAC, PRACTICAL and OCAC; 17.5% for CIMBA; and 7.5% for SNPs of common interest between the consortia. The final design comprised 220,123 SNPs, of which 211,155 were successfully manufactured. A total of 32,557 SNPs on the iCOGS array were selected based on 8 separate analyses of stage 1 of the CIMBA <italic>BRCA1</italic> GWAS that included 2,727 <italic>BRCA1</italic> mutation carriers <xref rid="pgen.1003212-Antoniou7" ref-type="bibr">[12]</xref>. After imputation for all SNPs in HapMap Phase II (CEU) a total of 2,568,349 (imputation r<sup>2</sup>>0.30) were available for analysis. Markers were evaluated for associations with: (1) breast cancer; (2) ovarian cancer; (3) breast cancer restricted to Class 1 mutations (loss-of-function mutations expected to result in a reduced transcript or protein level due to nonsense-mediated RNA decay); (4) breast cancer restricted to Class 2 mutations (mutations likely to generate stable proteins with potential residual or dominant negative function); (5) breast cancer by tumor ER-status; (6) breast cancer restricted to <italic>BRCA1</italic> 185delAG mutation carriers; (7) breast cancer restricted to <italic>BRCA1</italic> 5382insC mutation carriers; and (8) breast cancer by contrasting the genotype distributions in <italic>BRCA1</italic> mutation carriers, against the distribution in population-based controls. Analyses (1) and (2) were based on both imputed and observed genotypes, whereas the rest were based on only the observed genotypes. SNPs were ranked according to the 1 d.f. score-test for trend P-value (described below) and selected for inclusion based on nominal proportions of 61.5%, 20%, 2.5%, 2.5%, 2.5%, 0.5%, 0.5% and 10.0% for analyses (1) to (8). SNP duplications were not allowed and SNPs with a pairwise r<sup>2</sup>≥0.90 with a higher-ranking SNP were only allowed (up to a maximum of 2) if the P-value for association was <10<sup>−4</sup> for analyses (1) and (2) and <10<sup>−5</sup> for other analyses. SNPs with poor Illumina design scores were replaced by the SNP with the highest r<sup>2</sup> (among SNPs with r<sup>2</sup>>0.80 based on HapMap data) that had a good quality design score. The analysis of associations with breast and ovarian cancer risks presented here included all 32,557 SNPs on iCOGS that were selected on the basis of the <italic>BRCA1</italic> GWAS.</p></sec><sec id="s2d"><title>Genotyping and quality control</title><sec id="s2d1"><title>iCOGS genotyping</title><p>Genotyping was performed at Mayo Clinic. Genotypes for samples genotyped on the iCOGS array were called using Illumina's GenCall algorithm (<xref ref-type="supplementary-material" rid="pgen.1003212.s022">Text S1</xref>). A total of 13,510 samples were genotyped for 211,155 SNPs. The sample and SNP QC process is summarised in <xref ref-type="supplementary-material" rid="pgen.1003212.s015">Table S3</xref>. Of the 13,510 samples, 578 did not fulfil eligibility criteria based on phenotypic data and were excluded. A step-wise QC process was applied to the remaining samples and SNPs. Samples were excluded due to inferred gender errors, low call rates (<95%), low or high heterozygosity and sample duplications (cryptic and intended). Of the 211,155 markers genotyped, 9,913 were excluded due to Y-chromosome origin, low call rates (<95%), monomorphic SNPs, or SNPs with Hardy-Weinberg equilibrium (HWE) P<10<sup>−7</sup> under a country-stratified test statistic <xref rid="pgen.1003212-Robertson1" ref-type="bibr">[15]</xref> (<xref ref-type="supplementary-material" rid="pgen.1003212.s015">Table S3</xref>). SNPs that gave discordant genotypes among known sample duplicates were also excluded. Multi-dimensional scaling was used to exclude individuals of non-European ancestry. We selected 37,149 weakly correlated autosomal SNPs (pair-wise r<sup>2</sup><0.10) to compute the genomic kinship between all pairs of <italic>BRCA1</italic> carriers, along with 197 HapMap samples (CHB, JPT, YRI and CEU). These were converted to distances and subjected to multidimensional scaling (<xref ref-type="supplementary-material" rid="pgen.1003212.s001">Figure S1</xref>). Using the first two components, we calculated the proportion of European ancestry for each individual <xref rid="pgen.1003212-Antoniou7" ref-type="bibr">[12]</xref> and excluded samples with >22% non-European ancestry (<xref ref-type="supplementary-material" rid="pgen.1003212.s001">Figure S1</xref>). A total of 11,705 samples and 201,242 SNPs were available for analysis, including 31,812 SNPs selected by the <italic>BRCA1</italic> GWAS. The genotyping cluster plots for all SNPs that demonstrated genome-wide significance level of association or are presented below, were checked manually for quality (<xref ref-type="supplementary-material" rid="pgen.1003212.s002">Figure S2</xref>).</p></sec><sec id="s2d2"><title>iPLEX analysis</title><p>The most significant SNPs from 4 loci associated with ovarian cancer and 8 loci associated with breast cancer were selected (17 SNPs in total) for stage 3 genotyping. Genotyping using the iPLEX Mass Array platform was performed at Mayo Clinic. CIMBA QC procedures were applied. Samples that failed for ≥20% of the SNPs were excluded from the analysis. No SNPs failed HWE (P<0.01). The concordance among duplicates was ≥98%. Mutation carriers of self-reported non-European ancestry were excluded. A total of 2,646 <italic>BRCA1</italic> samples were eligible for analysis after QC.</p></sec></sec><sec id="s2e"><title>Statistical methods</title><p>The main analyses were focused on the evaluation of associations between each genotype and breast cancer or ovarian cancer risk separately. Analyses were carried out within a survival analysis framework. In the breast cancer analysis, the phenotype of each individual was defined by age at breast cancer diagnosis or age at last follow-up. Individuals were followed until the age of the first breast cancer diagnosis, ovarian cancer diagnosis, or bilateral prophylactic mastectomy, whichever occurred first; or last observation age. Mutation carriers censored at ovarian cancer diagnosis were considered unaffected. For the ovarian cancer analysis, the primary endpoint was the age at ovarian cancer diagnosis. Mutation carriers were followed until the age of ovarian cancer diagnosis, or risk-reducing salpingo-oophorectomy (RRSO) or age at last observation. In order to maximize the number of ovarian cancer cases, breast cancer was not considered as a censoring event in this analysis, and mutation carriers who developed ovarian cancer after a breast cancer diagnosis were considered as affected in the ovarian cancer analysis.</p><sec id="s2e1"><title>Association analysis</title><p>The majority of mutation carriers were sampled through families seen in genetic clinics. The first tested individual in a family is usually someone diagnosed with cancer at a relatively young age. Such study designs tend to lead to an over-sampling of affected individuals, and standard analytical methods like Cox regression may lead to biased estimates of the risk ratios <xref rid="pgen.1003212-Antoniou8" ref-type="bibr">[16]</xref>, <xref rid="pgen.1003212-Barnes1" ref-type="bibr">[17]</xref>. To adjust for this potential bias the data were analyzed within a survival analysis framework, by modeling the retrospective likelihood of the observed genotypes conditional on the disease phenotypes. A detailed description of the retrospective likelihood approach has been published <xref rid="pgen.1003212-Barnes1" ref-type="bibr">[17]</xref>, <xref rid="pgen.1003212-Antoniou9" ref-type="bibr">[18]</xref>. The associations between genotype and breast cancer risk at both stages were assessed using the 1 d.f. score test statistic based on this retrospective likelihood <xref rid="pgen.1003212-Barnes1" ref-type="bibr">[17]</xref>, <xref rid="pgen.1003212-Antoniou9" ref-type="bibr">[18]</xref>. To allow for the non-independence among related individuals, we accounted for the correlation between the genotypes by estimating the kinship coefficient for each pair of individuals using the available genomic data <xref rid="pgen.1003212-Antoniou8" ref-type="bibr">[16]</xref>, <xref rid="pgen.1003212-Amin1" ref-type="bibr">[19]</xref>, <xref rid="pgen.1003212-Leutenegger1" ref-type="bibr">[20]</xref> and by robust variance estimation based on reported family membership <xref rid="pgen.1003212-Boos1" ref-type="bibr">[21]</xref>. We chose to present P-values based on the kinship adjusted score test as it utilises the degree of relationship between individuals. A genome-wide level of significance of 5×10<sup>−8</sup> was used <xref rid="pgen.1003212-Wellcome1" ref-type="bibr">[22]</xref>. These analyses were performed in R using the GenABEL <xref rid="pgen.1003212-Aulchenko1" ref-type="bibr">[23]</xref> libraries and custom-written functions in FORTRAN and Python.</p><p>To estimate the magnitude of the associations (HRs), the effect of each SNP was modeled either as a per-allele HR (multiplicative model) or as genotype-specific HRs, and were estimated on the log-scale by maximizing the retrospective likelihood. The retrospective likelihood was fitted using the pedigree-analysis software MENDEL <xref rid="pgen.1003212-Barnes1" ref-type="bibr">[17]</xref>, <xref rid="pgen.1003212-Lange1" ref-type="bibr">[24]</xref>. As sample sizes varied substantially between contributing centers heterogeneity was examined at the country level. All analyses were stratified by country of residence and used calendar-year and cohort-specific breast cancer incidence rates for <italic>BRCA1</italic><xref rid="pgen.1003212-Antoniou10" ref-type="bibr">[25]</xref>. Countries with small number of mutation carriers were combined with neighbouring countries to ensure sufficiently large numbers within each stratum (<xref ref-type="supplementary-material" rid="pgen.1003212.s014">Table S2</xref>). USA and Canada were further stratified by reported Ashkenazi Jewish (AJ) ancestry due to large numbers of AJ carriers. In stage 3 analysis involving several countries with small numbers of mutation carriers, we assumed only 3 large strata (Europe, Australia, USA/Canada). The combined iCOGS stage and stage 3 analysis was also stratified by stage of the experiment. The analysis of associations by breast cancer ER-status was carried out by an extension of the retrospective likelihood approach to model the simultaneous effect of each SNP on more than one tumor subtype <xref rid="pgen.1003212-Mulligan1" ref-type="bibr">[26]</xref> (<xref ref-type="supplementary-material" rid="pgen.1003212.s022">Text S1</xref>).</p></sec><sec id="s2e2"><title>Competing risk analysis</title><p>The associations with breast and ovarian cancer risk simultaneously were assessed within a competing risk analysis framework <xref rid="pgen.1003212-Barnes1" ref-type="bibr">[17]</xref> by estimating HRs simultaneously for breast and ovarian cancer risk. This analysis provides unbiased estimates of association with both diseases and more powerful tests of association in cases where an association exists between a variant and at least one of the diseases <xref rid="pgen.1003212-Barnes1" ref-type="bibr">[17]</xref>. Each individual was assumed to be at risk of developing either breast or ovarian cancer, and the probabilities of developing each disease were assumed to be independent conditional on the underlying genotype. A different censoring process was used, whereby individuals were followed up to the age of the first breast or ovarian cancer diagnosis and were considered to have developed the corresponding disease. No follow-up was considered after the first cancer diagnosis. Individuals censored for breast cancer at the age of bilateral prophylactic mastectomy and for ovarian cancer at the age of RRSO were assumed to be unaffected for the corresponding disease. The remaining individuals were censored at the last observation age and were assumed to be unaffected for both diseases.</p></sec><sec id="s2e3"><title>Imputation</title><p>For the SNP selection process, the MACH software was used to impute non-genotyped SNPs based on the phased haplotypes from HapMap Phase II (CEU, release 22). The IMPUTE2 software <xref rid="pgen.1003212-Howie1" ref-type="bibr">[27]</xref> was used to impute non-genotyped SNPs for samples genotyped on the iCOGS array (stage 1 and 2 only), based on the 1,000 Genomes haplotypes (January 2012 version). Associations between each marker and cancer risk were assessed using a similar score test to that used for the observed SNPs, but based on the posterior genotype probabilities at each imputed marker for each individual. In all analyses, we considered only SNPs with imputation information/accuracy r<sup>2</sup>>0.30.</p></sec><sec id="s2e4"><title>Absolute breast and ovarian cancer risks by combined SNP profile</title><p>We estimated the absolute risk of developing breast and ovarian cancer based on the joint distribution of all SNPs that were significantly associated with risk for <italic>BRCA1</italic> mutation carriers based on methods previously applied to <italic>BRCA2</italic> carriers <xref rid="pgen.1003212-Antoniou11" ref-type="bibr">[28]</xref>. We assumed that the average, age-specific breast and ovarian cancer incidences for <italic>BRCA1</italic> mutation carriers, over all modifying loci, agreed with published penetrance estimates for <italic>BRCA1</italic><xref rid="pgen.1003212-Antoniou10" ref-type="bibr">[25]</xref>. The model assumed independence among the modifying loci and we used only the SNP with the strongest evidence of association from each region. We used only loci identified through the <italic>BRCA1</italic> GWAS that exhibited associations at a genome-wide significance level, and loci that were identified through population-based GWAS of breast or ovarian cancer risk, but were also associated with those risks for <italic>BRCA1</italic> mutation carriers. For each SNP, we used the per-allele HR and minor allele frequencies estimated from the present study. Genotype frequencies were obtained under the assumption of HWE.</p></sec></sec></sec><sec id="s3"><title>Results</title><p>Samples from 11,705 <italic>BRCA1</italic> carriers from 45 centers in 25 countries yielded high-quality data for 201,242 SNPs on the iCOGS array. The array included 31,812 <italic>BRCA1</italic> GWAS SNPs, which were analyzed here for their associations with breast and ovarian cancer risk for <italic>BRCA1</italic> mutation carriers (<xref ref-type="supplementary-material" rid="pgen.1003212.s014">Table S2</xref>). Of the 11,705 <italic>BRCA1</italic> mutation carriers, 2,387 samples had also been genotyped for stage 1 of the GWAS and 9,318 were unique to the stage 2 iCOGS study.</p><sec id="s3a"><title>Breast cancer associations</title><p>When restricting analysis to stage 2 samples (4,681 unaffected, 4,637 affected), there was little evidence of inflation in the association test-statistic (λ = 1.038; <xref ref-type="supplementary-material" rid="pgen.1003212.s003">Figure S3</xref>). Combined analysis of stage 1 and 2 samples (5,784 unaffected, 5,920 affected) revealed 66 SNPs in 28 regions with P<10<sup>−4</sup> (<xref ref-type="supplementary-material" rid="pgen.1003212.s004">Figure S4</xref>). These included variants from three loci (19p13, 6q25.1, 12p11) previously associated with breast cancer risk for <italic>BRCA1</italic> mutation carriers (<xref ref-type="table" rid="pgen-1003212-t001">Table 1</xref>). Further evaluation of 18 loci associated with breast cancer susceptibility in the general population found that only the <italic>TOX3</italic>, <italic>LSP1</italic>, 2q35 and <italic>RAD51L1</italic> loci were significantly associated with breast cancer for <italic>BRCA1</italic> carriers (<xref ref-type="table" rid="pgen-1003212-t001">Table 1</xref>, <xref ref-type="supplementary-material" rid="pgen.1003212.s016">Table S4</xref>).</p><table-wrap id="pgen-1003212-t001" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pgen.1003212.t001</object-id><label>Table 1</label><caption><title>Associations with breast or ovarian cancer risk for loci previously reported to be associated with cancer risk for <italic>BRCA1</italic> mutation carriers.</title></caption><alternatives><graphic id="pgen-1003212-t001-1" xlink:href="pgen.1003212.t001"></graphic><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col></colgroup><thead><tr><td align="left" rowspan="1" colspan="1">Locus</td><td colspan="4" align="left" rowspan="1">Previously published association in <italic>BRCA1</italic></td><td colspan="5" align="left" rowspan="1">Strongest association in current set of 31,812 <italic>BRCA1</italic> GWAS SNPs</td><td colspan="4" align="left" rowspan="1">Association for published SNP in set of all iCOGS SNPs</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">SNP</td><td align="left" rowspan="1" colspan="1">all1/all2 (freq)</td><td align="left" rowspan="1" colspan="1">HR (95%CI)</td><td align="left" rowspan="1" colspan="1">P</td><td align="left" rowspan="1" colspan="1">SNP</td><td align="left" rowspan="1" colspan="1">all1/all2 (freq)</td><td align="left" rowspan="1" colspan="1">r<sup>2</sup></td><td align="left" rowspan="1" colspan="1">HR (95%CI)</td><td align="left" rowspan="1" colspan="1">P</td><td align="left" rowspan="1" colspan="1">Best tag SNP (r<sup>2</sup>)</td><td align="left" rowspan="1" colspan="1">all1/all2 (freq)</td><td align="left" rowspan="1" colspan="1">HR (95%CI)</td><td align="left" rowspan="1" colspan="1">P</td></tr></thead><tbody><tr><td colspan="14" align="left" rowspan="1"><italic>Loci previously associated with breast cancer risk for BRCA1 carriers</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">19p13</td><td align="left" rowspan="1" colspan="1">rs8170</td><td align="left" rowspan="1" colspan="1">G/A (0.17)</td><td align="left" rowspan="1" colspan="1">1.26 (1.17–1.35)</td><td align="left" rowspan="1" colspan="1">2.3×10<sup>−9</sup></td><td align="left" rowspan="1" colspan="1">rs8100241</td><td align="left" rowspan="1" colspan="1">G/A (0.52)</td><td align="left" rowspan="1" colspan="1">0.31</td><td align="left" rowspan="1" colspan="1">0.84 (0.80–0.88)</td><td align="left" rowspan="1" colspan="1">4.3×10<sup>−13</sup></td><td align="left" rowspan="1" colspan="1">rs8170 (1.0)</td><td align="left" rowspan="1" colspan="1">G/A (0.17)</td><td align="left" rowspan="1" colspan="1">1.22 (1.14–1.29)</td><td align="left" rowspan="1" colspan="1">4.8×10<sup>−10</sup></td></tr><tr><td align="left" rowspan="1" colspan="1">6q25.1</td><td align="left" rowspan="1" colspan="1">rs2046210</td><td align="left" rowspan="1" colspan="1">C/T (0.35)</td><td align="left" rowspan="1" colspan="1">1.17 (1.11–1.23)</td><td align="left" rowspan="1" colspan="1">4.5×10<sup>−9</sup></td><td align="left" rowspan="1" colspan="1">rs3734805</td><td align="left" rowspan="1" colspan="1">A/C (0.08)</td><td align="left" rowspan="1" colspan="1">0.25</td><td align="left" rowspan="1" colspan="1">1.28 (1.18–1.39)</td><td align="left" rowspan="1" colspan="1">5×10<sup>−9</sup></td><td align="left" rowspan="1" colspan="1">rs2046210<xref ref-type="table-fn" rid="nt104">*</xref> (1.0)</td><td align="left" rowspan="1" colspan="1">G/A (0.35)</td><td align="left" rowspan="1" colspan="1">1.15 (1.10–1.21)</td><td align="left" rowspan="1" colspan="1">2.8×10<sup>−8</sup></td></tr><tr><td align="left" rowspan="1" colspan="1">12p11</td><td align="left" rowspan="1" colspan="1">rs10771399</td><td align="left" rowspan="1" colspan="1">A/G (0.11)</td><td align="left" rowspan="1" colspan="1">0.87 (0.81–0.94)</td><td align="left" rowspan="1" colspan="1">3.2×10<sup>−4</sup></td><td align="left" rowspan="1" colspan="1">rs7957915</td><td align="left" rowspan="1" colspan="1">A/G (0.14)</td><td align="left" rowspan="1" colspan="1">0.85</td><td align="left" rowspan="1" colspan="1">0.85 (0.79–0.91)</td><td align="left" rowspan="1" colspan="1">8.1×10<sup>−6</sup></td><td align="left" rowspan="1" colspan="1">rs10771399<xref ref-type="table-fn" rid="nt104">*</xref></td><td align="left" rowspan="1" colspan="1">A/G (0.11)</td><td align="left" rowspan="1" colspan="1">0.85 (0.79–0.92)</td><td align="left" rowspan="1" colspan="1">2.7×10<sup>−5</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>TOX3</italic></td><td align="left" rowspan="1" colspan="1">rs3803662</td><td align="left" rowspan="1" colspan="1">C/T (0.29)</td><td align="left" rowspan="1" colspan="1">1.09 (1.03–1.16)</td><td align="left" rowspan="1" colspan="1">0.0049</td><td align="left" rowspan="1" colspan="1">rs4784220</td><td align="left" rowspan="1" colspan="1">A/G (0.38)</td><td align="left" rowspan="1" colspan="1">0.52</td><td align="left" rowspan="1" colspan="1">1.08 (1.03–1.13)</td><td align="left" rowspan="1" colspan="1">0.0021</td><td align="left" rowspan="1" colspan="1">rs3803662<xref ref-type="table-fn" rid="nt104">*</xref></td><td align="left" rowspan="1" colspan="1">G/A (0.29)</td><td align="left" rowspan="1" colspan="1">1.05 (1.00–1.11)</td><td align="left" rowspan="1" colspan="1">0.075</td></tr><tr><td align="left" rowspan="1" colspan="1">2q35</td><td align="left" rowspan="1" colspan="1">rs13387042<xref ref-type="table-fn" rid="nt105">a</xref></td><td align="left" rowspan="1" colspan="1">G/A (0.52)</td><td align="left" rowspan="1" colspan="1">1.02 (0.96–1.07)</td><td align="left" rowspan="1" colspan="1">0.57</td><td align="left" rowspan="1" colspan="1">rs13389571</td><td align="left" rowspan="1" colspan="1">A/G (0.05)</td><td align="left" rowspan="1" colspan="1">0.02</td><td align="left" rowspan="1" colspan="1">0.86 (0.77–0.96)</td><td align="left" rowspan="1" colspan="1">0.011</td><td align="left" rowspan="1" colspan="1">rs13387042<xref ref-type="table-fn" rid="nt104">*</xref></td><td align="left" rowspan="1" colspan="1">A/G (0.48)</td><td align="left" rowspan="1" colspan="1">1.01 (0.96–1.06)</td><td align="left" rowspan="1" colspan="1">0.74</td></tr><tr><td colspan="14" align="left" rowspan="1"><italic>Known ovarian cancer susceptibility loci</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">9p22</td><td align="left" rowspan="1" colspan="1">rs3814113</td><td align="left" rowspan="1" colspan="1">T/C (0.34)</td><td align="left" rowspan="1" colspan="1">0.78 (0.72–0.85)</td><td align="left" rowspan="1" colspan="1">4.8×10<sup>−9</sup></td><td align="left" rowspan="1" colspan="1">rs3814113</td><td align="left" rowspan="1" colspan="1">A/G (0.34)</td><td align="left" rowspan="1" colspan="1">1.00</td><td align="left" rowspan="1" colspan="1">0.77 (0.71–0.83)</td><td align="left" rowspan="1" colspan="1">5.9×10<sup>−11</sup></td><td align="left" rowspan="1" colspan="1">rs3814113 (1.0)</td><td align="left" rowspan="1" colspan="1">A/G (0.34)</td><td align="left" rowspan="1" colspan="1">0.77 (0.71–0.83)</td><td align="left" rowspan="1" colspan="1">5.9×10<sup>−11</sup></td></tr><tr><td align="left" rowspan="1" colspan="1">2q31</td><td align="left" rowspan="1" colspan="1">rs2072590</td><td align="left" rowspan="1" colspan="1">T/C (0.31)</td><td align="left" rowspan="1" colspan="1">1.06 (0.98–1.14)</td><td align="left" rowspan="1" colspan="1">0.16</td><td align="left" rowspan="1" colspan="1">rs1026032</td><td align="left" rowspan="1" colspan="1">A/G (0.26)</td><td align="left" rowspan="1" colspan="1">0.75</td><td align="left" rowspan="1" colspan="1">1.08 (0.99–1.17)</td><td align="left" rowspan="1" colspan="1">0.064</td><td align="left" rowspan="1" colspan="1">rs2072590<xref ref-type="table-fn" rid="nt104">*</xref> (1.0)</td><td align="left" rowspan="1" colspan="1">C/A (0.32)</td><td align="left" rowspan="1" colspan="1">1.05 (0.97–1.14)</td><td align="left" rowspan="1" colspan="1">0.20</td></tr><tr><td align="left" rowspan="1" colspan="1">8q24</td><td align="left" rowspan="1" colspan="1">rs10088218</td><td align="left" rowspan="1" colspan="1">G/A (0.13)</td><td align="left" rowspan="1" colspan="1">0.89 (0.81–0.99)</td><td align="left" rowspan="1" colspan="1">0.029</td><td align="left" rowspan="1" colspan="1">rs9918771</td><td align="left" rowspan="1" colspan="1">A/C (0.17)</td><td align="left" rowspan="1" colspan="1">0.31</td><td align="left" rowspan="1" colspan="1">0.86 (0.78–0.95)</td><td align="left" rowspan="1" colspan="1">0.0021</td><td align="left" rowspan="1" colspan="1">rs10088218 (1.0)</td><td align="left" rowspan="1" colspan="1">G/A (0.13)</td><td align="left" rowspan="1" colspan="1">0.86 (0.78–0.96)</td><td align="left" rowspan="1" colspan="1">0.0096</td></tr><tr><td align="left" rowspan="1" colspan="1">3q25</td><td align="left" rowspan="1" colspan="1">rs2665390</td><td align="left" rowspan="1" colspan="1">T/C (0.075)</td><td align="left" rowspan="1" colspan="1">1.25 (1.10–1.42)</td><td align="left" rowspan="1" colspan="1">2.7×10<sup>−3</sup></td><td align="left" rowspan="1" colspan="1">rs7651446</td><td align="left" rowspan="1" colspan="1">C/A (0.043)</td><td align="left" rowspan="1" colspan="1">0.71</td><td align="left" rowspan="1" colspan="1">1.46 (1.25–1.71)</td><td align="left" rowspan="1" colspan="1">6.6×10<sup>−6</sup></td><td align="left" rowspan="1" colspan="1">rs344008 (1.0)</td><td align="left" rowspan="1" colspan="1">G/A (0.075)</td><td align="left" rowspan="1" colspan="1">1.21 (1.07–1.38)</td><td align="left" rowspan="1" colspan="1">3.8×10<sup>−3</sup></td></tr><tr><td align="left" rowspan="1" colspan="1">17q21</td><td align="left" rowspan="1" colspan="1">rs9303542</td><td align="left" rowspan="1" colspan="1">T/C (0.26)</td><td align="left" rowspan="1" colspan="1">1.08 (1.00–1.17)</td><td align="left" rowspan="1" colspan="1">0.06</td><td align="left" rowspan="1" colspan="1">rs11651753</td><td align="left" rowspan="1" colspan="1">G/A (0.43)</td><td align="left" rowspan="1" colspan="1">0.36</td><td align="left" rowspan="1" colspan="1">1.14 (1.06–1.23)</td><td align="left" rowspan="1" colspan="1">4.6×10<sup>−4</sup></td><td align="left" rowspan="1" colspan="1">rs9303542<xref ref-type="table-fn" rid="nt104">*</xref> (1.0)</td><td align="left" rowspan="1" colspan="1">A/G (0.26)</td><td align="left" rowspan="1" colspan="1">1.12 (1.04–1.22)</td><td align="left" rowspan="1" colspan="1">8.0×10<sup>−3</sup></td></tr><tr><td align="left" rowspan="1" colspan="1">19p13<xref ref-type="table-fn" rid="nt106">b</xref></td><td align="left" rowspan="1" colspan="1">rs67397200</td><td align="left" rowspan="1" colspan="1">C/G (0.28)</td><td align="left" rowspan="1" colspan="1">1.16 (1.05–1.29)</td><td align="left" rowspan="1" colspan="1">3.8×10<sup>−4</sup></td><td align="left" rowspan="1" colspan="1">c19_pos17158477</td><td align="left" rowspan="1" colspan="1">G/C (0.038)</td><td align="left" rowspan="1" colspan="1">0.01</td><td align="left" rowspan="1" colspan="1">0.64 (0.49–0.83)</td><td align="left" rowspan="1" colspan="1">7.0×10<sup>−4</sup></td><td align="left" rowspan="1" colspan="1">rs67397200 (c19_pos17262404)</td><td align="left" rowspan="1" colspan="1">G/C (0.28)</td><td align="left" rowspan="1" colspan="1">1.12 (1.01–1.23)</td><td align="left" rowspan="1" colspan="1">0.027</td></tr></tbody></table></alternatives><table-wrap-foot><fn id="nt101"><label></label><p>Freq = frequency of allele 2 in unaffected <italic>BRCA1</italic> carriers.</p></fn><fn id="nt102"><label></label><p>HR = Per allele Hazard Ratio associated with allele 2, under a single disease risk model, unless specified.</p></fn><fn id="nt103"><label></label><p>r<sup>2</sup>: correlation between the SNP in the present study and the published SNP.</p></fn><fn id="nt104"><label>*</label><p>SNP not in <italic>BRCA1</italic> GWAS SNP allocation on iCOGS chip.</p></fn><fn id="nt105"><label>a</label><p>: rs13387042 was previously found to be associated only under the 2-df model.</p></fn><fn id="nt106"><label>b</label><p>: analysis under a competing risks model.</p></fn></table-wrap-foot></table-wrap><p>After excluding SNPs from the known loci, there were 39 SNPs in 25 regions with P = 1.2×10<sup>−6</sup>–1.0×10<sup>−4</sup>. Twelve of these SNPs were genotyped by iPLEX in an additional 2,646 <italic>BRCA1</italic> carriers (1,252 unaffected, 1,394 affected, “stage 3” samples, <xref ref-type="supplementary-material" rid="pgen.1003212.s017">Table S5</xref>). There was additional evidence of association with breast cancer risk for four SNPs at two loci (P<0.01, <xref ref-type="table" rid="pgen-1003212-t002">Table 2</xref>). When all stages were combined, SNPs rs2290854 and rs6682208 (r<sup>2</sup> = 0.84) at 1q32, near <italic>MDM4</italic>, had combined <italic>P</italic>-values of association with breast cancer risk of 1.4×10<sup>−7</sup> and 4×10<sup>−7</sup>,respectively. SNPs rs11196174 and rs11196175 (r<sup>2</sup> = 0.96) at 10q25.3 (in <italic>TCF7L2</italic>) had combined P-values of 7.5×10<sup>−7</sup> and 1.2×10<sup>−6</sup>. Analysis within a competing risks framework, where associations with breast and ovarian cancer risks are evaluated simultaneously <xref rid="pgen.1003212-Barnes1" ref-type="bibr">[17]</xref>, revealed stronger associations with breast cancer risk for all 4 SNPs, but no associations with ovarian cancer (<xref ref-type="table" rid="pgen-1003212-t003">Table 3</xref>). In particular, we observed a genome-wide significant association between the minor allele of rs2290854 from 1q32 and breast cancer risk (per-allele HR: 1.14; 95%CI: 1.09–1.20; p = 2.7×10<sup>−8</sup>). Country-specific HR estimates for all SNPs are shown in <xref ref-type="supplementary-material" rid="pgen.1003212.s005">Figure S5</xref>. Analyses stratified by <italic>BRCA1</italic> mutation class revealed no significant evidence of a difference in the associations of any of the SNPs by the predicted functional consequences of <italic>BRCA1</italic> mutations (<xref ref-type="supplementary-material" rid="pgen.1003212.s018">Table S6</xref>). SNPs in the <italic>MDM4</italic> and <italic>TCF7L2</italic> loci were associated with breast cancer risk for both class1 and class2 mutation carriers.</p><table-wrap id="pgen-1003212-t002" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pgen.1003212.t002</object-id><label>Table 2</label><caption><title>Associations with breast and ovarian cancer risk for SNPs found to be associated with risk at all 3 stages of the experiment.</title></caption><alternatives><graphic id="pgen-1003212-t002-2" xlink:href="pgen.1003212.t002"></graphic><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col></colgroup><thead><tr><td align="left" rowspan="1" colspan="1">SNP, Chr, Position, Allele1/Allele2</td><td align="left" rowspan="1" colspan="1">Stage</td><td colspan="2" align="left" rowspan="1">Number</td><td colspan="2" align="left" rowspan="1">Allele 2 Frequency</td><td colspan="3" align="left" rowspan="1">HR<xref ref-type="table-fn" rid="nt107">*</xref> (95% CI)</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Unaffected</td><td align="left" rowspan="1" colspan="1">Affected</td><td align="left" rowspan="1" colspan="1">Unaffected</td><td align="left" rowspan="1" colspan="1">Affected</td><td align="left" rowspan="1" colspan="1">Per Allele</td><td align="left" rowspan="1" colspan="1">Heterozygote</td><td align="left" rowspan="1" colspan="1">Homozygote</td><td align="left" rowspan="1" colspan="1">P-trend</td></tr></thead><tbody><tr><td colspan="10" align="left" rowspan="1"><bold><italic>Breast Cancer</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs2290854, 1q32, 202782648, G/A</td><td align="left" rowspan="1" colspan="1">Stage 1</td><td align="left" rowspan="1" colspan="1">1104</td><td align="left" rowspan="1" colspan="1">1283</td><td align="left" rowspan="1" colspan="1">0.30</td><td align="left" rowspan="1" colspan="1">0.34</td><td align="left" rowspan="1" colspan="1">1.19 (1.08–1.30)</td><td align="left" rowspan="1" colspan="1">1.28 (1.12–1.47)</td><td align="left" rowspan="1" colspan="1">1.31 (1.06–1.61)</td><td align="left" rowspan="1" colspan="1">4.2×10<sup>−4</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stage 2</td><td align="left" rowspan="1" colspan="1">4681</td><td align="left" rowspan="1" colspan="1">4637</td><td align="left" rowspan="1" colspan="1">0.31</td><td align="left" rowspan="1" colspan="1">0.33</td><td align="left" rowspan="1" colspan="1">1.09 (1.03–1.16)</td><td align="left" rowspan="1" colspan="1">1.10 (1.02–1.19)</td><td align="left" rowspan="1" colspan="1">1.18 (1.03–1.35)</td><td align="left" rowspan="1" colspan="1">0.003</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stages1+2</td><td align="left" rowspan="1" colspan="1">5785</td><td align="left" rowspan="1" colspan="1">5920</td><td align="left" rowspan="1" colspan="1">0.31</td><td align="left" rowspan="1" colspan="1">0.33</td><td align="left" rowspan="1" colspan="1">1.12 (1.06–1.17)</td><td align="left" rowspan="1" colspan="1">1.15 (1.07–1.23)</td><td align="left" rowspan="1" colspan="1">1.21 (1.08–1.36)</td><td align="left" rowspan="1" colspan="1">1.7×10<sup>−5</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stage 3</td><td align="left" rowspan="1" colspan="1">1252</td><td align="left" rowspan="1" colspan="1">1393</td><td align="left" rowspan="1" colspan="1">0.30</td><td align="left" rowspan="1" colspan="1">0.33</td><td align="left" rowspan="1" colspan="1">1.19 (1.07–1.32)</td><td align="left" rowspan="1" colspan="1">1.24 (1.07–1.43)</td><td align="left" rowspan="1" colspan="1">1.36 (1.06–1.74)</td><td align="left" rowspan="1" colspan="1">0.0013</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Combined</td><td align="left" rowspan="1" colspan="1">7037</td><td align="left" rowspan="1" colspan="1">7313</td><td align="left" rowspan="1" colspan="1">0.31</td><td align="left" rowspan="1" colspan="1">0.33</td><td align="left" rowspan="1" colspan="1">1.13 (1.08–1.18)</td><td align="left" rowspan="1" colspan="1">1.16 (1.09–1.24)</td><td align="left" rowspan="1" colspan="1">1.24 (1.11–1.37)</td><td align="left" rowspan="1" colspan="1">1.4×10<sup>−7</sup></td></tr><tr><td align="left" rowspan="1" colspan="1">rs6682208, 1q32, 202832806, G/A</td><td align="left" rowspan="1" colspan="1">Stage 1</td><td align="left" rowspan="1" colspan="1">1104</td><td align="left" rowspan="1" colspan="1">1283</td><td align="left" rowspan="1" colspan="1">0.32</td><td align="left" rowspan="1" colspan="1">0.35</td><td align="left" rowspan="1" colspan="1">1.14 (1.04–1.25)</td><td align="left" rowspan="1" colspan="1">1.24 (1.09–1.42)</td><td align="left" rowspan="1" colspan="1">1.20 (0.98–1.47)</td><td align="left" rowspan="1" colspan="1">0.0070</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stage 2</td><td align="left" rowspan="1" colspan="1">4681</td><td align="left" rowspan="1" colspan="1">4637</td><td align="left" rowspan="1" colspan="1">0.32</td><td align="left" rowspan="1" colspan="1">0.34</td><td align="left" rowspan="1" colspan="1">1.10 (1.04–1.17)</td><td align="left" rowspan="1" colspan="1">1.09 (1.01–1.19)</td><td align="left" rowspan="1" colspan="1">1.21 (1.06–1.38)</td><td align="left" rowspan="1" colspan="1">0.0014</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stages1+2</td><td align="left" rowspan="1" colspan="1">5785</td><td align="left" rowspan="1" colspan="1">5920</td><td align="left" rowspan="1" colspan="1">0.32</td><td align="left" rowspan="1" colspan="1">0.34</td><td align="left" rowspan="1" colspan="1">1.11 (1.05–1.17)</td><td align="left" rowspan="1" colspan="1">1.13 (1.05–1.21)</td><td align="left" rowspan="1" colspan="1">1.21 (1.08–1.35)</td><td align="left" rowspan="1" colspan="1">5.4×10<sup>−5</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stage 3</td><td align="left" rowspan="1" colspan="1">1250</td><td align="left" rowspan="1" colspan="1">1394</td><td align="left" rowspan="1" colspan="1">0.30</td><td align="left" rowspan="1" colspan="1">0.34</td><td align="left" rowspan="1" colspan="1">1.19 (1.07–1.32)</td><td align="left" rowspan="1" colspan="1">1.31 (1.14–1.51)</td><td align="left" rowspan="1" colspan="1">1.28 (1.01–1.63)</td><td align="left" rowspan="1" colspan="1">8.6×10<sup>−4</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Combined</td><td align="left" rowspan="1" colspan="1">7035</td><td align="left" rowspan="1" colspan="1">7314</td><td align="left" rowspan="1" colspan="1">0.32</td><td align="left" rowspan="1" colspan="1">0.34</td><td align="left" rowspan="1" colspan="1">1.12 (1.07–1.17)</td><td align="left" rowspan="1" colspan="1">1.16 (1.09–1.23)</td><td align="left" rowspan="1" colspan="1">1.22 (1.11–1.35)</td><td align="left" rowspan="1" colspan="1">4.3×10<sup>−7</sup></td></tr><tr><td align="left" rowspan="1" colspan="1">rs11196174, 10q25.3, 114724086, A/G</td><td align="left" rowspan="1" colspan="1">Stage 1</td><td align="left" rowspan="1" colspan="1">1103</td><td align="left" rowspan="1" colspan="1">1282</td><td align="left" rowspan="1" colspan="1">0.27</td><td align="left" rowspan="1" colspan="1">0.32</td><td align="left" rowspan="1" colspan="1">1.15 (1.05–1.27)</td><td align="left" rowspan="1" colspan="1">1.17 (1.03–1.34)</td><td align="left" rowspan="1" colspan="1">1.31 (1.05–1.63)</td><td align="left" rowspan="1" colspan="1">0.0038</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stage 2</td><td align="left" rowspan="1" colspan="1">4681</td><td align="left" rowspan="1" colspan="1">4636</td><td align="left" rowspan="1" colspan="1">0.29</td><td align="left" rowspan="1" colspan="1">0.31</td><td align="left" rowspan="1" colspan="1">1.10 (1.04–1.17)</td><td align="left" rowspan="1" colspan="1">1.13 (1.04–1.23)</td><td align="left" rowspan="1" colspan="1">1.17 (1.01–1.35)</td><td align="left" rowspan="1" colspan="1">0.0017</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stages1+2</td><td align="left" rowspan="1" colspan="1">5784</td><td align="left" rowspan="1" colspan="1">5918</td><td align="left" rowspan="1" colspan="1">0.28</td><td align="left" rowspan="1" colspan="1">0.31</td><td align="left" rowspan="1" colspan="1">1.12 (1.06–1.18)</td><td align="left" rowspan="1" colspan="1">1.14 (1.06–1.23)</td><td align="left" rowspan="1" colspan="1">1.21 (1.07–1.37)</td><td align="left" rowspan="1" colspan="1">3.1×10<sup>−5</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stage 3</td><td align="left" rowspan="1" colspan="1">1251</td><td align="left" rowspan="1" colspan="1">1393</td><td align="left" rowspan="1" colspan="1">0.28</td><td align="left" rowspan="1" colspan="1">0.31</td><td align="left" rowspan="1" colspan="1">1.16 (1.05–1.29)</td><td align="left" rowspan="1" colspan="1">1.08 (0.93–1.25)</td><td align="left" rowspan="1" colspan="1">1.46 (1.15–1.85)</td><td align="left" rowspan="1" colspan="1">0.0057</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Combined</td><td align="left" rowspan="1" colspan="1">7035</td><td align="left" rowspan="1" colspan="1">7311</td><td align="left" rowspan="1" colspan="1">0.28</td><td align="left" rowspan="1" colspan="1">0.31</td><td align="left" rowspan="1" colspan="1">1.13 (1.07–1.18)</td><td align="left" rowspan="1" colspan="1">1.13 (1.06–1.21)</td><td align="left" rowspan="1" colspan="1">1.26 (1.13–1.40)</td><td align="left" rowspan="1" colspan="1">7.5×10<sup>−7</sup></td></tr><tr><td align="left" rowspan="1" colspan="1">rs11196175, 10q25.3, 114726604, A/G</td><td align="left" rowspan="1" colspan="1">Stage 1</td><td align="left" rowspan="1" colspan="1">1101</td><td align="left" rowspan="1" colspan="1">1280</td><td align="left" rowspan="1" colspan="1">0.27</td><td align="left" rowspan="1" colspan="1">0.31</td><td align="left" rowspan="1" colspan="1">1.15 (1.05–1.27)</td><td align="left" rowspan="1" colspan="1">1.18 (1.03–1.35)</td><td align="left" rowspan="1" colspan="1">1.29 (1.03–1.62)</td><td align="left" rowspan="1" colspan="1">0.0043</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stage 2</td><td align="left" rowspan="1" colspan="1">4674</td><td align="left" rowspan="1" colspan="1">4627</td><td align="left" rowspan="1" colspan="1">0.28</td><td align="left" rowspan="1" colspan="1">0.30</td><td align="left" rowspan="1" colspan="1">1.10 (1.03–1.17)</td><td align="left" rowspan="1" colspan="1">1.13 (1.04–1.22)</td><td align="left" rowspan="1" colspan="1">1.17 (1.01–1.35)</td><td align="left" rowspan="1" colspan="1">0.0020</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stages1+2</td><td align="left" rowspan="1" colspan="1">5775</td><td align="left" rowspan="1" colspan="1">5907</td><td align="left" rowspan="1" colspan="1">0.28</td><td align="left" rowspan="1" colspan="1">0.30</td><td align="left" rowspan="1" colspan="1">1.12 (1.06–1.18)</td><td align="left" rowspan="1" colspan="1">1.14 (1.06–1.22)</td><td align="left" rowspan="1" colspan="1">1.21 (1.07–1.37)</td><td align="left" rowspan="1" colspan="1">3.9×10<sup>−5</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stage 3</td><td align="left" rowspan="1" colspan="1">1251</td><td align="left" rowspan="1" colspan="1">1394</td><td align="left" rowspan="1" colspan="1">0.27</td><td align="left" rowspan="1" colspan="1">0.31</td><td align="left" rowspan="1" colspan="1">1.16 (1.04–1.29)</td><td align="left" rowspan="1" colspan="1">1.06 (0.91–1.22)</td><td align="left" rowspan="1" colspan="1">1.48 (1.17–1.87)</td><td align="left" rowspan="1" colspan="1">0.0075</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Combined</td><td align="left" rowspan="1" colspan="1">7026</td><td align="left" rowspan="1" colspan="1">7301</td><td align="left" rowspan="1" colspan="1">0.28</td><td align="left" rowspan="1" colspan="1">0.31</td><td align="left" rowspan="1" colspan="1">1.12 (1.07–1.18)</td><td align="left" rowspan="1" colspan="1">1.12 (1.05–1.20)</td><td align="left" rowspan="1" colspan="1">1.26 (1.13–1.41)</td><td align="left" rowspan="1" colspan="1">1.2×10<sup>−6</sup></td></tr><tr><td colspan="10" align="left" rowspan="1"><bold><italic>Ovarian Cancer</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs17631303, 17q21, 40872185, A/G</td><td align="left" rowspan="1" colspan="1">Stage 1</td><td align="left" rowspan="1" colspan="1">1797</td><td align="left" rowspan="1" colspan="1">574</td><td align="left" rowspan="1" colspan="1">0.19</td><td align="left" rowspan="1" colspan="1">0.25</td><td align="left" rowspan="1" colspan="1">1.46 (1.22–1.74)</td><td align="left" rowspan="1" colspan="1">1.36 (1.01–1.68)</td><td align="left" rowspan="1" colspan="1">2.46 (1.53–3.96)</td><td align="left" rowspan="1" colspan="1">1.3×10<sup>−5</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stage 2</td><td align="left" rowspan="1" colspan="1">7996</td><td align="left" rowspan="1" colspan="1">1257</td><td align="left" rowspan="1" colspan="1">0.19</td><td align="left" rowspan="1" colspan="1">0.21</td><td align="left" rowspan="1" colspan="1">1.20 (1.07–1.35)</td><td align="left" rowspan="1" colspan="1">1.10 (0.96–1.26)</td><td align="left" rowspan="1" colspan="1">1.83 (1.34–2.48)</td><td align="left" rowspan="1" colspan="1">1.5×10<sup>−3</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stages1+2</td><td align="left" rowspan="1" colspan="1">9793</td><td align="left" rowspan="1" colspan="1">1831</td><td align="left" rowspan="1" colspan="1">0.19</td><td align="left" rowspan="1" colspan="1">0.22</td><td align="left" rowspan="1" colspan="1">1.27 (1.16–1.40)</td><td align="left" rowspan="1" colspan="1">1.15 (1.03–1.29)</td><td align="left" rowspan="1" colspan="1">2.03 (1.16–2.61)</td><td align="left" rowspan="1" colspan="1">3.0×10<sup>−7</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stage 3</td><td align="left" rowspan="1" colspan="1">2204</td><td align="left" rowspan="1" colspan="1">442</td><td align="left" rowspan="1" colspan="1">0.17</td><td align="left" rowspan="1" colspan="1">0.21</td><td align="left" rowspan="1" colspan="1">1.27 (1.07–1.51)</td><td align="left" rowspan="1" colspan="1">1.24 (0.99–1.56)</td><td align="left" rowspan="1" colspan="1">1.67 (1.07–2.62)</td><td align="left" rowspan="1" colspan="1">0.014</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Combined</td><td align="left" rowspan="1" colspan="1">11997</td><td align="left" rowspan="1" colspan="1">2273</td><td align="left" rowspan="1" colspan="1">0.19</td><td align="left" rowspan="1" colspan="1">0.22</td><td align="left" rowspan="1" colspan="1">1.27 (1.17–1.38)</td><td align="left" rowspan="1" colspan="1">1.17 (1.06–1.29)</td><td align="left" rowspan="1" colspan="1">1.95 (1.57–2.42)</td><td align="left" rowspan="1" colspan="1">1.4×10<sup>−8</sup></td></tr><tr><td align="left" rowspan="1" colspan="1">rs183211, 17q21, 42143493, G/A</td><td align="left" rowspan="1" colspan="1">Stage 1</td><td align="left" rowspan="1" colspan="1">1812</td><td align="left" rowspan="1" colspan="1">575</td><td align="left" rowspan="1" colspan="1">0.22</td><td align="left" rowspan="1" colspan="1">0.28</td><td align="left" rowspan="1" colspan="1">1.45 (1.23–1.71)</td><td align="left" rowspan="1" colspan="1">1.37 (1.11–1.69)</td><td align="left" rowspan="1" colspan="1">2.29 (1.53–3.41)</td><td align="left" rowspan="1" colspan="1">2.5×10<sup>−5</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stage 2</td><td align="left" rowspan="1" colspan="1">8054</td><td align="left" rowspan="1" colspan="1">1264</td><td align="left" rowspan="1" colspan="1">0.23</td><td align="left" rowspan="1" colspan="1">0.25</td><td align="left" rowspan="1" colspan="1">1.20 (1.07–1.33)</td><td align="left" rowspan="1" colspan="1">1.13 (0.99–1.28)</td><td align="left" rowspan="1" colspan="1">1.62 (1.22–2.14)</td><td align="left" rowspan="1" colspan="1">1.1×10<sup>−3</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stages1+2</td><td align="left" rowspan="1" colspan="1">9866</td><td align="left" rowspan="1" colspan="1">1839</td><td align="left" rowspan="1" colspan="1">0.23</td><td align="left" rowspan="1" colspan="1">0.26</td><td align="left" rowspan="1" colspan="1">1.25 (1.15–1.37)</td><td align="left" rowspan="1" colspan="1">1.16 (1.04–1.29)</td><td align="left" rowspan="1" colspan="1">1.83 (1.46–2.28)</td><td align="left" rowspan="1" colspan="1">5.7×10<sup>−7</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stage 3</td><td align="left" rowspan="1" colspan="1">2204</td><td align="left" rowspan="1" colspan="1">442</td><td align="left" rowspan="1" colspan="1">0.22</td><td align="left" rowspan="1" colspan="1">0.26</td><td align="left" rowspan="1" colspan="1">1.25 (1.06–1.48)</td><td align="left" rowspan="1" colspan="1">1.15 (0.92–1.44)</td><td align="left" rowspan="1" colspan="1">1.79 (1.21–2.67)</td><td align="left" rowspan="1" colspan="1">0.018</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Combined</td><td align="left" rowspan="1" colspan="1">12070</td><td align="left" rowspan="1" colspan="1">2281</td><td align="left" rowspan="1" colspan="1">0.23</td><td align="left" rowspan="1" colspan="1">0.26</td><td align="left" rowspan="1" colspan="1">1.25 (1.16–1.35)</td><td align="left" rowspan="1" colspan="1">1.16 (1.05–1.27)</td><td align="left" rowspan="1" colspan="1">1.82 (1.5–2.21)</td><td align="left" rowspan="1" colspan="1">3.1×10<sup>−8</sup></td></tr><tr><td align="left" rowspan="1" colspan="1">rs4691139, 4q32.3, 166128171, A/G</td><td align="left" rowspan="1" colspan="1">Stage 1</td><td align="left" rowspan="1" colspan="1">1812</td><td align="left" rowspan="1" colspan="1">575</td><td align="left" rowspan="1" colspan="1">0.47</td><td align="left" rowspan="1" colspan="1">0.53</td><td align="left" rowspan="1" colspan="1">1.24 (1.08–1.42)</td><td align="left" rowspan="1" colspan="1">1.46 (1.13–1.88)</td><td align="left" rowspan="1" colspan="1">1.55 (1.16–2.05)</td><td align="left" rowspan="1" colspan="1">3.6×10<sup>−3</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stage 2</td><td align="left" rowspan="1" colspan="1">8054</td><td align="left" rowspan="1" colspan="1">1264</td><td align="left" rowspan="1" colspan="1">0.48</td><td align="left" rowspan="1" colspan="1">0.52</td><td align="left" rowspan="1" colspan="1">1.18 (1.08–1.29)</td><td align="left" rowspan="1" colspan="1">1.29 (1.10–1.50)</td><td align="left" rowspan="1" colspan="1">1.40 (1.17–1.67)</td><td align="left" rowspan="1" colspan="1">1.3×10<sup>−4</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stages1+2</td><td align="left" rowspan="1" colspan="1">9866</td><td align="left" rowspan="1" colspan="1">1839</td><td align="left" rowspan="1" colspan="1">0.48</td><td align="left" rowspan="1" colspan="1">0.52</td><td align="left" rowspan="1" colspan="1">1.20 (1.11–1.29)</td><td align="left" rowspan="1" colspan="1">1.33 (1.17–1.52)</td><td align="left" rowspan="1" colspan="1">1.44 (1.24–1.67)</td><td align="left" rowspan="1" colspan="1">1.1×10<sup>−6</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stage 3</td><td align="left" rowspan="1" colspan="1">2204</td><td align="left" rowspan="1" colspan="1">441</td><td align="left" rowspan="1" colspan="1">0.47</td><td align="left" rowspan="1" colspan="1">0.52</td><td align="left" rowspan="1" colspan="1">1.20 (1.04–1.39)</td><td align="left" rowspan="1" colspan="1">1.19 (0.91–1.54)</td><td align="left" rowspan="1" colspan="1">1.44 (1.08–1.94)</td><td align="left" rowspan="1" colspan="1">9×10<sup>−3</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Combined</td><td align="left" rowspan="1" colspan="1">12070</td><td align="left" rowspan="1" colspan="1">2280</td><td align="left" rowspan="1" colspan="1">0.48</td><td align="left" rowspan="1" colspan="1">0.52</td><td align="left" rowspan="1" colspan="1">1.20 (1.17–1.38)</td><td align="left" rowspan="1" colspan="1">1.30 (1.16–1.46)</td><td align="left" rowspan="1" colspan="1">1.44 (1.26–1.65)</td><td align="left" rowspan="1" colspan="1">3.4×10<sup>−8</sup></td></tr></tbody></table></alternatives><table-wrap-foot><fn id="nt107"><label>*</label><p>HRs estimated under the single disease risk models.</p></fn></table-wrap-foot></table-wrap><table-wrap id="pgen-1003212-t003" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pgen.1003212.t003</object-id><label>Table 3</label><caption><title>Analysis of associations with breast and ovarian cancer risk simultaneously (competing risks analysis) for SNPs found to be associated with breast or ovarian cancer.</title></caption><alternatives><graphic id="pgen-1003212-t003-3" xlink:href="pgen.1003212.t003"></graphic><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col></colgroup><thead><tr><td align="left" rowspan="1" colspan="1">SNP, Chr, Position, Allele1/Allele2</td><td align="left" rowspan="1" colspan="1">Unaffected (Allele2 Freq)</td><td align="left" rowspan="1" colspan="1">Ovarian Cancer (Allele2 Freq)</td><td align="left" rowspan="1" colspan="1">Breast Cancer (Allele2 Freq)</td><td colspan="2" align="left" rowspan="1">Ovarian Cancer</td><td colspan="2" align="left" rowspan="1">Breast Cancer</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">HR (95% CI)</td><td align="left" rowspan="1" colspan="1">P</td><td align="left" rowspan="1" colspan="1">HR (95% CI)</td><td align="left" rowspan="1" colspan="1">P</td></tr></thead><tbody><tr><td colspan="8" align="left" rowspan="1"><italic>SNPs found to be associated with breast cancer risk.</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">rs2290854, 1q32, 202782648, G/A</td><td align="left" rowspan="1" colspan="1">5473 (0.31)</td><td align="left" rowspan="1" colspan="1">1618 (0.31)</td><td align="left" rowspan="1" colspan="1">7259 (0.33)</td><td align="left" rowspan="1" colspan="1">1.08 (0.99–1.18)</td><td align="left" rowspan="1" colspan="1">0.08</td><td align="left" rowspan="1" colspan="1">1.14 (1.09–1.20)</td><td align="left" rowspan="1" colspan="1">2.7×10<sup>−8</sup></td></tr><tr><td align="left" rowspan="1" colspan="1">rs6682208, 1q32, 202832806, G/A</td><td align="left" rowspan="1" colspan="1">5471 (0.32)</td><td align="left" rowspan="1" colspan="1">1618 (0.33)</td><td align="left" rowspan="1" colspan="1">7260 (0.34)</td><td align="left" rowspan="1" colspan="1">1.08 (1.00–1.18)</td><td align="left" rowspan="1" colspan="1">0.06</td><td align="left" rowspan="1" colspan="1">1.13 (1.08–1.19)</td><td align="left" rowspan="1" colspan="1">1.2×10<sup>−7</sup></td></tr><tr><td align="left" rowspan="1" colspan="1">rs11196174, 10q25.3, 114724086, A/G</td><td align="left" rowspan="1" colspan="1">5471 (0.28)</td><td align="left" rowspan="1" colspan="1">1618 (0.29)</td><td align="left" rowspan="1" colspan="1">7257 (0.31)</td><td align="left" rowspan="1" colspan="1">1.07 (0.98–1.16)</td><td align="left" rowspan="1" colspan="1">0.16</td><td align="left" rowspan="1" colspan="1">1.14 (1.08–1.19)</td><td align="left" rowspan="1" colspan="1">3.2×10<sup>−7</sup></td></tr><tr><td align="left" rowspan="1" colspan="1">rs11196175, 10q25.3, 114726604, A/G</td><td align="left" rowspan="1" colspan="1">5465 (0.28)</td><td align="left" rowspan="1" colspan="1">1615 (0.29)</td><td align="left" rowspan="1" colspan="1">7247 (0.31)</td><td align="left" rowspan="1" colspan="1">1.07 (0.97–1.16)</td><td align="left" rowspan="1" colspan="1">0.16</td><td align="left" rowspan="1" colspan="1">1.14 (1.08–1.19)</td><td align="left" rowspan="1" colspan="1">3.9×10<sup>−7</sup></td></tr><tr><td colspan="8" align="left" rowspan="1"><italic>SNPs found to be associated with ovarian cancer risk</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">rs17631303, 17q21, 40872185, A/G</td><td align="left" rowspan="1" colspan="1">5445 (0.19)</td><td align="left" rowspan="1" colspan="1">1610 (0.22)</td><td align="left" rowspan="1" colspan="1">7215 (0.19)</td><td align="left" rowspan="1" colspan="1">1.26 (1.14–1.39)</td><td align="left" rowspan="1" colspan="1">1.0×10<sup>−5</sup></td><td align="left" rowspan="1" colspan="1">1.02 (0.96–1.08)</td><td align="left" rowspan="1" colspan="1">0.52</td></tr><tr><td align="left" rowspan="1" colspan="1">rs183211, 17q21, 42143493, G/A</td><td align="left" rowspan="1" colspan="1">5473 (0.23)</td><td align="left" rowspan="1" colspan="1">1618 (0.26)</td><td align="left" rowspan="1" colspan="1">7260 (0.23)</td><td align="left" rowspan="1" colspan="1">1.25 (1.14–1.38)</td><td align="left" rowspan="1" colspan="1">3.5×10<sup>−6</sup></td><td align="left" rowspan="1" colspan="1">1.02 (0.97–1.08)</td><td align="left" rowspan="1" colspan="1">0.42</td></tr><tr><td align="left" rowspan="1" colspan="1">rs4691139, 4q32.3, 166128171, A/G</td><td align="left" rowspan="1" colspan="1">5473 (0.48)</td><td align="left" rowspan="1" colspan="1">1617 (0.53)</td><td align="left" rowspan="1" colspan="1">7269 (0.48)</td><td align="left" rowspan="1" colspan="1">1.21 (1.12–1.31)</td><td align="left" rowspan="1" colspan="1">2.8×10<sup>−6</sup></td><td align="left" rowspan="1" colspan="1">0.98 (0.93–1.02)</td><td align="left" rowspan="1" colspan="1">0.28</td></tr></tbody></table></alternatives></table-wrap><p>Both the 1q32 and 10q25.3 loci were primarily associated with ER-negative breast cancer for <italic>BRCA1</italic> (rs2290854: ER-negative HR = 1.16, 95%CI: 1.10–1.22, P = 1.2×10<sup>−7</sup>; rs11196174: HR = 1.14, 95%CI: 1.07–1.20, P = 9.6×10<sup>−6</sup>), although the differences between the ER-negative and ER-positive HRs were not significant (<xref ref-type="supplementary-material" rid="pgen.1003212.s019">Table S7</xref>). Given that ER-negative breast cancers in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers are phenotypically similar <xref rid="pgen.1003212-Mavaddat1" ref-type="bibr">[29]</xref>, we also evaluated associations between these SNPs and ER-negative breast cancer in 8,211 <italic>BRCA2</italic> mutation carriers. While the 10q25.3 SNPs were not associated with overall or ER-negative breast cancer risk for <italic>BRCA2</italic> carriers, the 1q32 SNPs were associated with ER-negative (rs2290854 HR = 1.16, 95%CI:1.01–1.34, P = 0.033; rs6682208 HR = 1.19, 95%CI:1.04–1.35, P = 0.016), but not ER-positive breast cancer (rs2290854 P-diff = 0.006; rs6682208 P-diff = 0.001). Combining the <italic>BRCA1</italic> and <italic>BRCA2</italic> samples provided strong evidence of association with ER-negative breast cancer (rs2290854: P = 1.25×10<sup>−8</sup>; rs6682208: P = 2.5×10<sup>−7</sup>).</p><p>The iCOGS array included additional SNPs from the 1q32 region that were not chosen based on the <italic>BRCA1</italic> GWAS. Of these non-<italic>BRCA1</italic> GWAS SNPs, only SNP rs4951407 was more significantly associated with risk than the <italic>BRCA1</italic>-GWAS selected SNPs (P = 3.3×10<sup>−6</sup>, HR = 1.12, 95%CI:1.07–1.18, using stage 1 and stage 2 samples). The evidence of association with breast cancer risk was again stronger under the competing risks analysis (HR = 1.14, 95%CI: 1.08–1.20, P = 6.1×10<sup>−7</sup>). Backward multiple regression analysis, considering only the genotyped SNPs (P<0.01), revealed that the most parsimonious model included only rs4951407. SNPs from the 1000 Genomes Project, were imputed for the stage 1 and stage 2 samples (<xref ref-type="supplementary-material" rid="pgen.1003212.s006">Figure S6</xref>). Only imputed SNP rs12404974, located between <italic>PIK3C2B</italic> and <italic>MDM4</italic> (r<sup>2</sup> = 0.77 with rs4951407), was more significantly associated with breast cancer (P = 2.7×10<sup>−6</sup>) than any of the genotyped SNPs. None of the genotyped or imputed SNPs from 10q25.3 provided P-values smaller than those for rs11196174 and rs11196175 (<xref ref-type="supplementary-material" rid="pgen.1003212.s007">Figure S7</xref>).</p></sec><sec id="s3b"><title>Ovarian cancer associations</title><p>Analyses of associations with ovarian cancer risk using the stage 2 samples (8,054 unaffected, 1,264 affected) revealed no evidence of inflation in the association test-statistic (λ = 1.039, <xref ref-type="supplementary-material" rid="pgen.1003212.s003">Figure S3</xref>). In the combined analysis of stage 1 and 2 samples (9866 unaffected, 1839 affected), 62 SNPs in 17 regions were associated with ovarian cancer risk for <italic>BRCA1</italic> carriers at P<10<sup>−4</sup> (<xref ref-type="supplementary-material" rid="pgen.1003212.s003">Figure S3</xref>). These included SNPs in the 9p22 and 3q25 loci previously associated with ovarian cancer risk in both the general population and <italic>BRCA1</italic> carriers <xref rid="pgen.1003212-Ramus1" ref-type="bibr">[6]</xref>, <xref rid="pgen.1003212-Ramus2" ref-type="bibr">[7]</xref> (<xref ref-type="table" rid="pgen-1003212-t001">Table 1</xref>). Associations (P<0.01) with ovarian cancer risk were also observed for SNPs in three other known ovarian cancer susceptibility loci (8q24, 17q21, 19p13), but not 2q31 (<xref ref-type="table" rid="pgen-1003212-t001">Table 1</xref>). For all loci except 9p22, SNPs were identified that displayed smaller P-values of association than previously published results <xref rid="pgen.1003212-Couch1" ref-type="bibr">[5]</xref>–<xref rid="pgen.1003212-Ramus2" ref-type="bibr">[7]</xref>.</p><p>After excluding SNPs from known ovarian cancer susceptibility regions, there were 48 SNPs in 15 regions with P = 5×10<sup>−7</sup> to 10<sup>−4</sup>. Five SNPs from four of these loci were genotyped in the stage 3 samples (2,204 unaffected, 442 with ovarian cancer). Three SNPs showed additional evidence of association with ovarian cancer risk (P<0.02, <xref ref-type="table" rid="pgen-1003212-t002">Table 2</xref>; <xref ref-type="supplementary-material" rid="pgen.1003212.s017">Table S5</xref>). In the combined stage 1–3 analyses, SNPs rs17631303 and rs183211 (r<sup>2</sup> = 0.68) on chromosome 17q21.31 had P-values for association of 1×10<sup>−8</sup> and 3×10<sup>−8</sup> respectively, and rs4691139 at 4q32.3 had a P-value of 3.4×10<sup>−8</sup> (<xref ref-type="table" rid="pgen-1003212-t002">Table 2</xref>).</p><p>The minor alleles of rs17631303 (HR = 1.27, 95%CI:1.17–1.38) and rs183211 (HR = 1.25, 95%CI: 1.16–1.35) at 17q21.31 were associated with increased ovarian cancer risk (<xref ref-type="table" rid="pgen-1003212-t002">Table 2</xref>). Analysis of the associations within a competing risks framework, revealed no association with breast cancer risk (<xref ref-type="table" rid="pgen-1003212-t003">Table 3</xref>). The ovarian cancer effect size was maintained in the competing risk analysis but the significance of the association was slightly weaker (P = 2×10<sup>−6</sup>–1×10<sup>−5</sup>). This is expected because 663 ovarian cancer cases occurring after a primary breast cancer diagnosis were excluded for this analysis. The evidence of association was somewhat stronger under the genotype-specific model (2-df P = 1.6×10<sup>−9</sup> and P = 2.6×10<sup>−9</sup> for rs17631303 and rs183211 respectively in all samples combined) with larger HR estimates for the rare homozygote genotypes than those expected under a multiplicative model (<xref ref-type="table" rid="pgen-1003212-t002">Table 2</xref>).</p><p>Previous studies of the known common ovarian cancer susceptibility alleles found significant associations with ovarian cancer for both <italic>BRCA1</italic> and <italic>BRCA2</italic> carriers <xref rid="pgen.1003212-Ramus1" ref-type="bibr">[6]</xref>, <xref rid="pgen.1003212-Ramus2" ref-type="bibr">[7]</xref>. Thus, we evaluated the associations between the 17q21.31 SNPs and ovarian cancer risk for <italic>BRCA2</italic> carriers using iCOGS genotype data (7580 unaffected and 631 affected). Both rs17631303 and rs183211 were associated with ovarian cancer risk for <italic>BRCA2</italic> carriers (P = 1.98×10<sup>−4</sup> and 9.26×10<sup>−4</sup>), with similar magnitude and direction of association as for <italic>BRCA1</italic> carriers. Combined analysis of <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers provided strong evidence of association (P = 2.80×10<sup>−10</sup> and 2.01×10<sup>−9</sup>, <xref ref-type="table" rid="pgen-1003212-t004">Table 4</xref>).</p><table-wrap id="pgen-1003212-t004" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pgen.1003212.t004</object-id><label>Table 4</label><caption><title>Associations with SNPs at the novel 17q21 region with ovarian cancer risk for <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers.</title></caption><alternatives><graphic id="pgen-1003212-t004-4" xlink:href="pgen.1003212.t004"></graphic><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col></colgroup><thead><tr><td align="left" rowspan="1" colspan="1">SNP, Allele1/Allele2</td><td colspan="4" align="left" rowspan="1"><italic>BRCA1</italic> (Stage 1 & 2 samples)</td><td colspan="4" align="left" rowspan="1"><italic>BRCA2</italic></td><td align="left" rowspan="1" colspan="1"><italic>BRCA1</italic> & <italic>BRCA2</italic> samples combined</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Unaffected (All2 freq)</td><td align="left" rowspan="1" colspan="1">Ovarian Cancer (All2 freq)</td><td align="left" rowspan="1" colspan="1">HR<xref ref-type="table-fn" rid="nt108">*</xref> (95%CI)</td><td align="left" rowspan="1" colspan="1">P-trend</td><td align="left" rowspan="1" colspan="1">Unaffected (All2 freq)</td><td align="left" rowspan="1" colspan="1">Ovarian Cancer (All2 freq)</td><td align="left" rowspan="1" colspan="1">HR<xref ref-type="table-fn" rid="nt108">*</xref> (95%CI)</td><td align="left" rowspan="1" colspan="1">P-trend</td><td align="left" rowspan="1" colspan="1">P-trend</td></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">rs17631303, A/G</td><td align="left" rowspan="1" colspan="1">9793 (0.19)</td><td align="left" rowspan="1" colspan="1">1831 (0.22)</td><td align="left" rowspan="1" colspan="1">1.27 (1.16–1.40)</td><td align="left" rowspan="1" colspan="1">3.04×10<sup>−7</sup></td><td align="left" rowspan="1" colspan="1">7481 (0.19)</td><td align="left" rowspan="1" colspan="1">626 (0.24)</td><td align="left" rowspan="1" colspan="1">1.32 (1.15–1.52)</td><td align="left" rowspan="1" colspan="1">1.98×10<sup>−4</sup></td><td align="left" rowspan="1" colspan="1">2.80×10<sup>−10</sup></td></tr><tr><td align="left" rowspan="1" colspan="1">rs2077606, G/A</td><td align="left" rowspan="1" colspan="1">9736 (0.19)</td><td align="left" rowspan="1" colspan="1">1810 (0.22)</td><td align="left" rowspan="1" colspan="1">1.27 (1.15–1.40)</td><td align="left" rowspan="1" colspan="1">5.51×10<sup>−7</sup></td><td align="left" rowspan="1" colspan="1">7421 (0.19)</td><td align="left" rowspan="1" colspan="1">613 (0.23)</td><td align="left" rowspan="1" colspan="1">1.31 (1.13–1.50)</td><td align="left" rowspan="1" colspan="1">5.60×10<sup>−4</sup></td><td align="left" rowspan="1" colspan="1">1.27×10<sup>−9</sup></td></tr><tr><td align="left" rowspan="1" colspan="1">rs2532348, A/G</td><td align="left" rowspan="1" colspan="1">9511 (0.21)</td><td align="left" rowspan="1" colspan="1">1789 (0.24)</td><td align="left" rowspan="1" colspan="1">1.25 (1.14–1.37)</td><td align="left" rowspan="1" colspan="1">8.71×10<sup>−7</sup></td><td align="left" rowspan="1" colspan="1">7407 (0.23)</td><td align="left" rowspan="1" colspan="1">615 (0.28)</td><td align="left" rowspan="1" colspan="1">1.33 (1.17–1.51)</td><td align="left" rowspan="1" colspan="1">4.62×10<sup>−5</sup></td><td align="left" rowspan="1" colspan="1">2.49×10<sup>−10</sup></td></tr><tr><td align="left" rowspan="1" colspan="1">rs183211, G/A</td><td align="left" rowspan="1" colspan="1">9866 (0.23)</td><td align="left" rowspan="1" colspan="1">1839 (0.26)</td><td align="left" rowspan="1" colspan="1">1.25 (1.15–1.37)</td><td align="left" rowspan="1" colspan="1">5.67×10<sup>−7</sup></td><td align="left" rowspan="1" colspan="1">7580 (0.25)</td><td align="left" rowspan="1" colspan="1">631 (0.30)</td><td align="left" rowspan="1" colspan="1">1.26 (1.11–1.43)</td><td align="left" rowspan="1" colspan="1">9.26×10<sup>−4</sup></td><td align="left" rowspan="1" colspan="1">2.01×10<sup>−9</sup></td></tr><tr><td align="left" rowspan="1" colspan="1">rs169201, A/G</td><td align="left" rowspan="1" colspan="1">9865 (0.20)</td><td align="left" rowspan="1" colspan="1">1839 (0.23)</td><td align="left" rowspan="1" colspan="1">1.27 (1.15–1.37)</td><td align="left" rowspan="1" colspan="1">5.04×10<sup>−7</sup></td><td align="left" rowspan="1" colspan="1">7578 (0.21)</td><td align="left" rowspan="1" colspan="1">631 (0.26)</td><td align="left" rowspan="1" colspan="1">1.36 (1.19–1.55)</td><td align="left" rowspan="1" colspan="1">1.72×10<sup>−5</sup></td><td align="left" rowspan="1" colspan="1">6.24×10<sup>−11</sup></td></tr><tr><td align="left" rowspan="1" colspan="1">rs199443, G/A</td><td align="left" rowspan="1" colspan="1">9849 (0.20)</td><td align="left" rowspan="1" colspan="1">1835 (0.23)</td><td align="left" rowspan="1" colspan="1">1.26 (1.15–1.39)</td><td align="left" rowspan="1" colspan="1">5.15×10<sup>−7</sup></td><td align="left" rowspan="1" colspan="1">7580 (0.21)</td><td align="left" rowspan="1" colspan="1">631 (0.26)</td><td align="left" rowspan="1" colspan="1">1.35 (1.18–1.54)</td><td align="left" rowspan="1" colspan="1">2.57×10<sup>−5</sup></td><td align="left" rowspan="1" colspan="1">8.87×10<sup>−11</sup></td></tr><tr><td align="left" rowspan="1" colspan="1">rs199534, A/C</td><td align="left" rowspan="1" colspan="1">9865 (0.20)</td><td align="left" rowspan="1" colspan="1">1839 (0.23)</td><td align="left" rowspan="1" colspan="1">1.26 (1.15–1.39)</td><td align="left" rowspan="1" colspan="1">6.26×10<sup>−7</sup></td><td align="left" rowspan="1" colspan="1">7575 (0.21)</td><td align="left" rowspan="1" colspan="1">630 (0.26)</td><td align="left" rowspan="1" colspan="1">1.35 (1.18–1.55)</td><td align="left" rowspan="1" colspan="1">1.90×10<sup>−5</sup></td><td align="left" rowspan="1" colspan="1">8.57×10<sup>−11</sup></td></tr></tbody></table></alternatives><table-wrap-foot><fn id="nt108"><label>*</label><p>HRs estimated under the single disease risk model.</p></fn></table-wrap-foot></table-wrap><p>The combined analysis of stage 1 and 2 samples, and <italic>BRCA2</italic> carriers, identified seven SNPs on the iCOGS array (pairwise r<sup>2</sup> range: 0.68–1.00) from a 1.3 Mb (40.8–42.1 Mb, build 36.3) region of 17q21.31 that were strongly associated (P<1.27×10<sup>−9</sup>) with ovarian cancer risk (<xref ref-type="table" rid="pgen-1003212-t004">Table 4</xref>, <xref ref-type="fig" rid="pgen-1003212-g002">Figure 2</xref>). Stepwise-regression analysis based on observed genotype data retained only one of the seven SNPs in the model, but it was not possible to distinguish between the SNPs. Imputation through the 1000 Genomes Project, revealed several SNPs in 17q21.31 with stronger associations (<xref ref-type="fig" rid="pgen-1003212-g002">Figure 2</xref>, <xref ref-type="supplementary-material" rid="pgen.1003212.s020">Table S8</xref>) than the most significant genotyped SNP in the combined <italic>BRCA1/2</italic> analysis (rs169201, P = 6.24×10<sup>−11</sup>). The most significant SNP (rs140338099 (17-44034340), P = 3×10<sup>−12</sup>), located in <italic>MAPT</italic>, was highly correlated (r<sup>2</sup> = 0.78) with rs169201 in <italic>NSF</italic> (<xref ref-type="fig" rid="pgen-1003212-g002">Figure 2</xref>). This locus appears to be distinct from a previously identified ovarian cancer susceptibility locus located >1 Mb distal on 17q21 (spanning 43.3–44.3 Mb, build 36.3) <xref rid="pgen.1003212-Goode1" ref-type="bibr">[30]</xref>. None of the SNPs in the novel region were strongly correlated with any of the SNPs in the 43.3–44.3 Mb region (maximum r<sup>2</sup> = 0.07, <xref ref-type="supplementary-material" rid="pgen.1003212.s008">Figure S8</xref>). The most significantly associated SNP from the <italic>BRCA1</italic> GWAS from the 43.3–44.3 Mb locus was rs11651753 (p = 4.6×10<sup>−4</sup>) (<xref ref-type="table" rid="pgen-1003212-t001">Table 1</xref>) (r<sup>2</sup><0.023 with the seven most significant SNPs in the novel 17q21.31 region). An analysis of the joint associations of rs11651753 and rs17631303 from the two 17q21 loci with ovarian cancer risk for <italic>BRCA1</italic> carriers (Stage 1 and 2 samples) revealed that both SNPs remained significant in the model (P-for inclusion = 0.001 for rs11651753, 1.2×10<sup>−6</sup> for rs17631303), further suggesting that the two regions are independently associated with ovarian cancer for <italic>BRCA1</italic> carriers.</p><fig id="pgen-1003212-g002" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pgen.1003212.g002</object-id><label>Figure 2</label><caption><title>Mapping of the 17q21 locus. </title><p><italic>Top 3 panels:</italic> P-values of association (−log<sub>10</sub> scale) with ovarian cancer risk for genotyped and imputed SNPs (1000 Genomes Project CEU), by chromosome position (b.37) at the 17q21 region, for <italic>BRCA1</italic>, <italic>BRCA2</italic> mutation carriers and combined. Results based on the kinship-adjusted score test statistic (1 d.f.). <italic>Fourth panel:</italic> Genes in the region spanning (43.4–44.9 Mb, b.37) and the location of the most significant genotyped SNPs (in red font) and imputed SNPs (in black font). <italic>Bottom panel:</italic> Pairwise r<sup>2</sup> values for genotyped SNPs on iCOG array in the 17q21 region covering positions (43.4–44.9 Mb, b.37).</p></caption><graphic xlink:href="pgen.1003212.g002"></graphic></fig><p>The minor allele of rs4691139 at the novel 4q32.3 region was also associated with an increased ovarian cancer risk for <italic>BRCA1</italic> carriers (per-allele HR = 1.20, 95%CI:1.17–1.38, <xref ref-type="table" rid="pgen-1003212-t002">Table 2</xref>), but was not associated with breast cancer risk (<xref ref-type="table" rid="pgen-1003212-t003">Table 3</xref>). No other SNPs from the 4q32.3 region on the iCOGS array were more significantly associated with ovarian cancer for <italic>BRCA1</italic> carriers. Analysis of associations with variants identified through 1000 Genomes Project-based imputation of the Stage 1 and 2 samples, revealed 19 SNPs with stronger evidence of association (P = 5.4×10<sup>−7</sup> to 1.1×10<sup>−6</sup>) than rs4691139 (<xref ref-type="supplementary-material" rid="pgen.1003212.s009">Figure S9</xref>). All were highly correlated (pairwise r<sup>2</sup>>0.89) and the most significant (rs4588418) had r<sup>2</sup> = 0.97 with rs4691139. There was no evidence for association between rs4691139 and ovarian cancer risk for <italic>BRCA2</italic> carriers (HR = 1.08, 95%CI: 0.96–1.21, P = 0.22).</p></sec><sec id="s3c"><title>Absolute risks of developing breast and ovarian cancer</title><p>The current analyses suggest that 10 loci are now known to be associated with breast cancer risk for <italic>BRCA1</italic> mutation carriers: 1q32, 10q25.3, 19p13, 6q25.1, 12p11, <italic>TOX3</italic>, 2q35, <italic>LSP1</italic> and <italic>RAD51L1</italic> all reported here and <italic>TERT</italic><xref rid="pgen.1003212-Bojesen1" ref-type="bibr">[31]</xref>. Similarly, seven loci are associated with ovarian cancer risk for <italic>BRCA1</italic> mutation carriers: 9p22, 8q24, 3q25, 17q21, 19p13, 17q21.31 and 4q32.3. <xref ref-type="supplementary-material" rid="pgen.1003212.s010">Figure S10</xref> shows the range of combined HRs at different percentiles of the combined genotype distribution, based on the single SNP HR and minor allele estimates from <xref ref-type="table" rid="pgen-1003212-t001">Table 1</xref>, <xref ref-type="table" rid="pgen-1003212-t002">Table 2</xref>, and <xref ref-type="supplementary-material" rid="pgen.1003212.s016">Table S4</xref> and for TERT from Bojesen et al <xref rid="pgen.1003212-Bojesen1" ref-type="bibr">[31]</xref> and assuming that all SNPs interact multiplicatively. Relative to <italic>BRCA1</italic> mutation carriers at lowest risk, the median, 5<sup>th</sup> and 95<sup>th</sup> percentile breast cancer HRs were 3.40, 2.27, and 5.35 respectively. These translate to absolute risks of developing breast cancer by age 80 of 65%, 51% and 81% for those at median, 5<sup>th</sup> and 95<sup>th</sup> percentiles of the combined genotype distribution (<xref ref-type="fig" rid="pgen-1003212-g003">Figure 3</xref>, <xref ref-type="supplementary-material" rid="pgen.1003212.s010">Figure S10</xref>). Similarly, the median, 5<sup>th</sup> and 95<sup>th</sup> percentile combined HRs for ovarian cancer were 6.53, 3.75 and 11.12 respectively, relative to those at lowest ovarian cancer risk (<xref ref-type="supplementary-material" rid="pgen.1003212.s010">Figure S10</xref>). These HRs translate to absolute risks of developing ovarian cancer of 44%, 28% and 63% by age 80 for the median, 5<sup>th</sup> and 95<sup>th</sup> percentile of the combined genotype distribution (<xref ref-type="fig" rid="pgen-1003212-g003">Figure 3</xref>).</p><fig id="pgen-1003212-g003" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pgen.1003212.g003</object-id><label>Figure 3</label><caption><title>Predicted breast and ovarian cancer absolute risks for <italic>BRCA1</italic> mutation carriers at the 5<sup>th</sup>, 10<sup>th</sup>, 90<sup>th</sup>, and 95<sup>th</sup> percentiles of the combined SNP profile distributions.</title><p>The minimum, maximum and average risks are also shown. Predicted cancer risks are based on the associations of known breast or ovarian cancer susceptibility loci (identified through GWAS) with cancer risk for <italic>BRCA1</italic> mutation carriers and loci identified through the present study. Breast cancer risks based on the associations with: 1q32, 10q25.3, 19p13, 6q25.1, 12p11, <italic>TOX3</italic>, 2q35, <italic>LSP1</italic>, <italic>RAD51L1</italic> (based on HR and minor allele frequency estimates from <xref ref-type="table" rid="pgen-1003212-t001">Table 1</xref>, <xref ref-type="table" rid="pgen-1003212-t002">Table 2</xref>, and <xref ref-type="supplementary-material" rid="pgen.1003212.s016">Table S4</xref>) and <italic>TERT</italic><xref rid="pgen.1003212-Bojesen1" ref-type="bibr">[31]</xref>. Ovarian cancer risks based on the associations with: 9p22, 8q24, 3q25, 17q21, 19p13 (<xref ref-type="table" rid="pgen-1003212-t001">Table 1</xref>) and 17q21.31, 4q32.3 (<xref ref-type="table" rid="pgen-1003212-t002">Table 2</xref>). Only the top SNP from each region was chosen. Average breast and ovarian cancer risks were obtained from published data <xref rid="pgen.1003212-Antoniou10" ref-type="bibr">[25]</xref>. The methods for calculating the predicted risks have been described previously <xref rid="pgen.1003212-Antoniou11" ref-type="bibr">[28]</xref>.</p></caption><graphic xlink:href="pgen.1003212.g003"></graphic></fig></sec></sec><sec id="s4"><title>Discussion</title><p>In this study we analyzed data from 11,705 <italic>BRCA1</italic> mutation carriers from CIMBA who were genotyped using the iCOGS high-density custom array, which included 31,812 SNPs selected on the basis of a <italic>BRCA1</italic> GWAS. This study forms the large-scale replication stage of the first GWAS of breast and ovarian cancer risk modifiers for <italic>BRCA1</italic> mutation carriers. We have identified a novel locus at 1q32, containing the <italic>MDM4</italic> oncogene, that is associated with breast cancer risk for <italic>BRCA1</italic> mutation carriers (P<5×10<sup>−8</sup>). A separate locus at 10q23.5, containing the <italic>TCF7L2</italic> gene, provided strong evidence of association with breast cancer risk for <italic>BRCA1</italic> carriers but did not reach a GWAS level of significance. We have also identified two novel loci associated with ovarian cancer for <italic>BRCA1</italic> mutation carriers at 17q21.31 and 4q32.2 (P<5×10<sup>−8</sup>). We further confirmed associations with loci previously shown to be associated with breast or ovarian cancer risk for <italic>BRCA1</italic> mutation carriers. In most cases stronger associations were detected with either the same SNP reported previously (due to increased sample size) or other SNPs in the regions. Future fine mapping studies of these loci will aim to identify potentially causal variants for the observed associations.</p><p>Although the 10q25.3 locus did not reach the strict GWAS level of significance for association with breast cancer risk, the association was observed at all three independent stages of the experiment. Additional evidence for the involvement of this locus in breast cancer susceptibility comes from parallel studies of the Breast Cancer Association Consortium (BCAC). SNPs at 10q25.3 had also been independently selected for inclusion on the iCOGS array through population based GWAS of breast cancer. Analyses of those SNPs in BCAC iCOGS studies also found that SNPs at 10q25.3 were associated with breast cancer risk in the general population <xref rid="pgen.1003212-Michailidou1" ref-type="bibr">[32]</xref>. Thus, 10q25.3 is likely a breast cancer risk-modifying locus for <italic>BRCA1</italic> mutation carriers. The most significant SNPs at 10q25.3 were located in <italic>TCF7L2</italic>, a transcription factor that plays a key role in the Wnt signaling pathway and in glucose homeostasis, and is expressed in normal and malignant breast tissue (The Cancer Genome Atlas (TCGA)). Variation in the <italic>TCF7L2</italic> locus has previously been associated with Type 2 diabetes in a number of GWAS. The most significantly associated SNPs with Type 2 diabetes (rs7903146 and rs4506565) <xref rid="pgen.1003212-Wellcome1" ref-type="bibr">[22]</xref>, <xref rid="pgen.1003212-Sladek1" ref-type="bibr">[33]</xref> were also associated with breast cancer risk for <italic>BRCA1</italic> mutation carriers in stage 1 and 2 analyses (p = 3.7×10<sup>−4</sup> and p = 2.5×10<sup>−4</sup> respectively); these SNPs were correlated with the most significant hit (rs11196174) for <italic>BRCA1</italic> breast cancer (r<sup>2</sup> = 0.40 and 0.37 based on stage 1 and 2 samples). This raises the possibility that variants in this locus influence breast cancer indirectly through effects on cellular metabolism.</p><p>We found that SNPs at 1q32 were primarily associated with ER-negative breast cancer risk for <italic>BRCA1</italic> mutation carriers. There was also evidence of association with ER-negative breast cancer for <italic>BRCA2</italic> mutation carriers. SNPs at the 1q32 region were independently selected for inclusion on iCOGS through GWAS of breast cancer in the general population by BCAC. In parallel analyses of iCOGS data by BCAC, 1q32 was found to be associated with ER-negative breast cancer <xref rid="pgen.1003212-GarciaClosas1" ref-type="bibr">[34]</xref> but not overall breast cancer risk <xref rid="pgen.1003212-Michailidou1" ref-type="bibr">[32]</xref>. Taken together, these results are in agreement with our findings and in line with the observation that the majority of <italic>BRCA1</italic> breast cancers are ER-negative. However, they are not in agreement with a previous smaller candidate-gene study that found an association between a correlated SNP in <italic>MDM4</italic> (r<sup>2</sup>>0.85) and overall breast cancer risk <xref rid="pgen.1003212-Atwal1" ref-type="bibr">[35]</xref>. The 1q32 locus includes the <italic>MDM4</italic> oncogene which plays a role in regulation of p53 and MDM2 and the apoptotic response to cell stress. <italic>MDM4</italic> is expressed in breast tissue and is amplified and overexpressed along with <italic>LRRN2</italic> and <italic>PIK3C2B</italic> in breast and other tumor types (TCGA) <xref rid="pgen.1003212-Curtis1" ref-type="bibr">[36]</xref>–<xref rid="pgen.1003212-Wade1" ref-type="bibr">[38]</xref>. Although fine mapping will be necessary to identify the functionally relevant SNPs in this locus, we found evidence of cis-regulatory variation impacting <italic>MDM4</italic> expression <xref rid="pgen.1003212-Fairfax1" ref-type="bibr">[39]</xref>–<xref rid="pgen.1003212-Grundberg1" ref-type="bibr">[41]</xref> (<xref ref-type="supplementary-material" rid="pgen.1003212.s022">Text S1</xref>, <xref ref-type="supplementary-material" rid="pgen.1003212.s021">Table S9</xref>, <xref ref-type="supplementary-material" rid="pgen.1003212.s011">Figure S11</xref>), suggesting that common variation in the 1q32 locus may influence the risk of breast cancer through direct effects on <italic>MDM4</italic> expression.</p><p>Several correlated SNPs at 17q21.31 from the iCOGS array provided strong evidence of association with ovarian cancer risk in both <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers. A subsequent analysis of these SNPs, which were selected through the <italic>BRCA1</italic> GWAS, in case-control samples from the Ovarian Cancer Association Consortium (OCAC), revealed that the 17q21.31 locus is associated with ovarian cancer risk in the general population [Wey et al, personal communication]. Thus, 17q21.31 is likely a novel susceptibility locus for ovarian cancer in <italic>BRCA1</italic> mutation carriers. The most significant associations at 17q21.31 were clustered in a large region of strong linkage disequilibrium which has previously been identified as a “17q21.31 inversion” (∼900 kb long) consisting of two haplotypes (termed H1 and H2) <xref rid="pgen.1003212-Stefansson1" ref-type="bibr">[42]</xref>. The minor allele of rs2532348 (MAF = 0.21), which tags H2, was associated with increased ovarian cancer risk for <italic>BRCA1</italic> mutation carriers (<xref ref-type="table" rid="pgen-1003212-t004">Table 4</xref>). The 1.3 Mb 17q21.31 locus contains 13 genes and several predicted pseudogenes (<xref ref-type="fig" rid="pgen-1003212-g002">Figure 2</xref>), several of which are expressed in normal ovarian surface epithelium and ovarian adenocarcinoma <xref rid="pgen.1003212-Bowen1" ref-type="bibr">[43]</xref>. Variation in this region has been associated with Parkinson's disease (<italic>MAPT</italic>, <italic>PLEKHM1</italic>, <italic>NSF</italic>, <italic>c17orf69</italic>) progressive supranuclear palsy (<italic>MAPT</italic>), celiac disease (<italic>WNT3</italic>), bone mineral density (<italic>CRHR1</italic>) (NHGRI GWAS catalog) and intracranial volume <xref rid="pgen.1003212-Ikram1" ref-type="bibr">[44]</xref>. Of the top hits for these phenotypes, SNP rs199533 in <italic>NSF</italic>, previously associated with Parkinson's disease <xref rid="pgen.1003212-SimonSanchez1" ref-type="bibr">[45]</xref> and rs9915547 associated with intracranial volume <xref rid="pgen.1003212-Ikram1" ref-type="bibr">[44]</xref> were strongly associated with ovarian cancer (P<10<sup>−9</sup> in <italic>BRCA1/2</italic> combined). Whether these phenotypes have shared causal variants in this locus remains to be elucidated. Further exploration of the functional relevance of the strongest hits in the 17q21.31 locus (P<10<sup>−8</sup> in <italic>BRCA1/2</italic> combined) provided evidence that cis-regulatory variation alters expression of several genes at 17q21, including <italic>PLEKHM1</italic>, <italic>c17orf69</italic>, <italic>ARHGAP27</italic>, <italic>MAPT</italic>, <italic>KANSL1</italic> and <italic>WNT3</italic><xref rid="pgen.1003212-Fairfax1" ref-type="bibr">[39]</xref>, <xref rid="pgen.1003212-Grundberg1" ref-type="bibr">[41]</xref> (<xref ref-type="supplementary-material" rid="pgen.1003212.s021">Table S9</xref>, <xref ref-type="supplementary-material" rid="pgen.1003212.s012">Figure S12</xref>), suggesting that ovarian cancer risk may be associated with altered expression of one or more genes in this region.</p><p>Our analyses revealed that a second novel locus at 4q32.3 was also associated with ovarian cancer risk for <italic>BRCA1</italic> mutation carries (P<5×10<sup>−8)</sup>. However, we found no evidence of association for these SNPs with ovarian cancer risk for <italic>BRCA2</italic> mutation carriers using 8,211 CIMBA samples genotyped using the iCOGS array. Likewise, no evidence of association was found between rs4691139 at 4q32.3 and ovarian cancer risk in the general population based on data by OCAC data derived from 18,174 cases and 26,134 controls (odds ratio = 1.00, 95%CI:0.97–1.04, P = 0.76) <xref rid="pgen.1003212-Pharoah1" ref-type="bibr">[46]</xref>. The confidence intervals rule out a comparable effect to that found in <italic>BRCA1</italic> carriers. Therefore, our findings may represent a <italic>BRCA1</italic>-specific association with ovarian cancer risk, the first of its kind. The 4q32.2 region contains several members of the <italic>TRIM</italic> (Tripartite motif containing) gene family, <italic>c4orf39</italic> and <italic>TMEM192</italic>. <italic>TRIM60</italic>, <italic>c4orf39</italic> and <italic>TMEM19</italic>2 are expressed in normal ovarian epithelium and/or ovarian tumors (TCGA).</p><p>In summary, we have identified a novel locus at 1q32 associated with breast cancer risk for <italic>BRCA1</italic> mutation carriers, which was also associated with ER-negative breast cancer for <italic>BRCA2</italic> carriers and in the general population. A separate locus at 10q23.5 provided strong evidence of association with breast cancer risk for <italic>BRCA1</italic> carriers. We have also identified 2 novel loci associated with ovarian cancer for <italic>BRCA1</italic> mutation carriers. Of these, the 4q32.2 locus was associated with ovarian cancer risk for <italic>BRCA1</italic> carriers but not for <italic>BRCA2</italic> carriers or in the general population. Additional functional characterisation of the loci will further improve our understanding of the biology of breast and ovarian cancer development in <italic>BRCA1</italic> carriers. Taken together with other identified genetic modifiers, 10 loci are now known to be associated with breast cancer risk for <italic>BRCA1</italic> mutation carriers (1q32, 10q25.3, 19p13, 6q25.1, 12p11, <italic>TOX3</italic>, 2q35, <italic>LSP1</italic>, <italic>RAD51L1</italic> and <italic>TERT</italic> and seven loci are known to be associated with ovarian cancer risk for <italic>BRCA1</italic> mutation carriers (9p22, 8q24, 3q25, 17q21, 19p13 and 17q21.31, 4q32.3).</p><p>As <italic>BRCA1</italic> mutations confer high breast and ovarian cancer risks, the results from the present study, taken together with other identified genetic modifiers, demonstrate for the first time that they can result in large differences in the absolute risk of developing breast or ovarian cancer for <italic>BRCA1</italic> between genotypes. For example, the breast cancer lifetime risks for the 5% of <italic>BRCA1</italic> carriers at lowest risk are predicted to be 28–50% compared to 81–100% for the 5% at highest risk (<xref ref-type="fig" rid="pgen-1003212-g003">Figure 3</xref>). Based on the distribution of ovarian cancer risk modifiers, the 5% of <italic>BRCA1</italic> mutation carriers at lowest risk will have a lifetime risk of developing ovarian cancer of 28% or lower whereas the 5% at highest risk will have a lifetime risk of 63% or higher. Similarly, the breast cancer risk by age 40 is predicted to be 4–9% for the 5% of <italic>BRCA1</italic> carriers at lowest risk compared to 20–49% for the 5% at highest risk, whereas the ovarian cancer risk at age 50 ranges from 3–7% for the 5% at lowest risk and from 18–47% for the 5% at highest risk. The risks at all ages for the 10% at highest or lowest risk of breast and ovarian cancer are predicted to be similar to those for the highest and lowest 5%. Thus, at least 20% of BRCA1 mutation carriers are predicted to have absolute risks of disease that are different from the average <italic>BRCA1</italic> carriers. These large differences in cancer risks may have practical implications for the clinical management of <italic>BRCA1</italic> mutation carriers, for example in deciding the timing of interventions. Such risks, in combination with other lifestyle and hormonal risk factors could be incorporated into cancer risk prediction algorithms for use by clinical genetics centers. These algorithms could then be used to inform the development of effective and consistent clinical recommendations for the clinical management of <italic>BRCA1</italic> mutation carriers.</p></sec><sec sec-type="supplementary-material" id="s5"><title>Supporting Information</title><supplementary-material content-type="local-data" id="pgen.1003212.s001"><label>Figure S1</label><caption><p>Multidimensional scaling of stage 1 and stage 2 (genotyped on iCOGS) samples. Panel A: Graphical representation of the first two components, for the <italic>BRCA1</italic> carriers, for subgroups defined by the common 185delAG (c.68_69delAG) <italic>BRCA1</italic> Jewish founder mutation, the 5382insC (c.5266dupC) Eastern European founder mutation and Hapap individuals (CEU: European; ASI: Includes CHB and JPT populations; YRI: African). Panel B: Red dots represent the samples with >22% non-European ancestry, excluded from the analysis.</p><p>(PDF)</p></caption><media xlink:href="pgen.1003212.s001.pdf"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pgen.1003212.s002"><label>Figure S2</label><caption><p>Genotyping cluster plots in the <italic>BRCA1</italic> samples for the key associated SNPs.</p><p>(PDF)</p></caption><media xlink:href="pgen.1003212.s002.pdf"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pgen.1003212.s003"><label>Figure S3</label><caption><p>Quantile-quantile plot for the kinship adjusted score test statistic for stage 2 samples (1 degree of freedom χ<sup>2</sup> trend test) for the associations with breast cancer (panel A) and ovarian cancer (panel B) risk for <italic>BRCA1</italic> mutation carriers. The y = x line corresponds to the expected distribution, under the hypothesis of no inflation. Inflation was estimated using the values of the lowest 90% test statistics.</p><p>(PDF)</p></caption><media xlink:href="pgen.1003212.s003.pdf"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pgen.1003212.s004"><label>Figure S4</label><caption><p>P-values (on −log<sub>10</sub> scale) by chromosomal position, for the associations of 31,812 <italic>BRCA1</italic> GWAS SNPs with breast (panel A) and ovarian (panel B) cancer risk for <italic>BRCA1</italic> mutation carriers in the combined stage 1 and stage 2 samples. Blue lines correspond to a P-value of 10<sup>−5</sup>; red lines correspond to P-value 5×10<sup>−8</sup>.</p><p>(PDF)</p></caption><media xlink:href="pgen.1003212.s004.pdf"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pgen.1003212.s005"><label>Figure S5</label><caption><p>Forest plots of the associations by country of residence of <italic>BRCA1</italic> mutation carriers in the combined stage 1, stage 2 and stage 3 samples for SNPs found to be associated with breast and ovarian cancer risk for <italic>BRCA1</italic> mutation carriers. Squares indicate the country specific, per-allele HR estimates for the SNPs. The area of the square is proportional to the inverse of the variance of the estimate. Horizontal lines indicate 95% confidence intervals. There was some evidence of heterogeneity in country-specific HR estimates for the rs2290854 and rs6682208 SNP (P = 0.04 and 0.02 respectively, <xref ref-type="supplementary-material" rid="pgen.1003212.s003">Figure S3</xref>), but after accounting for opposite effects of these SNPs in Finland/Denmark, there was no evidence of heterogeneity. There was some evidence of heterogeneity in the country-specific HRs for rs17631303 (P-het = 0.004, df = 19) but this was no longer present after excluding one country (Poland, P-het = 0.12, df = 18), or when restricting analyses to Stage 1 and 2 samples only (P-het = 0.09, df = 19). There was no evidence of heterogeneity for correlated SNP rs183211 (P-het = 0.10). There was no evidence of hereterogeneity in the country-specific HRs for any of the other SNPs (P>0.68).</p><p>(PDF)</p></caption><media xlink:href="pgen.1003212.s005.pdf"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pgen.1003212.s006"><label>Figure S6</label><caption><p><italic>MDM4</italic> regional association plot using <italic>BRCA1</italic> stage 1 and stage 2 samples. P-values for association (−log<sub>10</sub> scale) with breast cancer risk for <italic>BRCA1</italic> mutation carriers for genotyped SNPs (diamond symbols ◊) and SNPs imputed from the 1000 genomes project data (square symbols □), by position (hg18) on chromosome 1. Red gradient represents r<sup>2</sup> value with the most significant genotyped SNP rs4951407. The blue peaks represent recombination rate in the region.</p><p>(PDF)</p></caption><media xlink:href="pgen.1003212.s006.pdf"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pgen.1003212.s007"><label>Figure S7</label><caption><p><italic>TCF7L2</italic> regional association plot using <italic>BRCA1</italic> stage 1 and stage 2 samples. P-values for association (−log<sub>10</sub> scale) with breast cancer risk for <italic>BRCA1</italic> mutation carriers for genotyped SNPs (diamond symbols ◊) and SNPs imputed from the 1000 genomes project data (square symbols □), by position (hg18) on chromosome 1. Missing genotypes were replaced by imputed results. Red gradient represents r<sup>2</sup> value with the most significant genotyped SNP rs11196174. The blue peaks represent recombination rate in the region.</p><p>(PDF)</p></caption><media xlink:href="pgen.1003212.s007.pdf"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pgen.1003212.s008"><label>Figure S8</label><caption><p>Linkage disequilibrium patterns between the SNPs in the novel (17q21.31) and previously identified regions on 17q21. SNPs in the novel region are uncorrelated with SNPs in the 43.3–44.3 Mb region (positions according to hg build 36.3).</p><p>(PDF)</p></caption><media xlink:href="pgen.1003212.s008.pdf"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pgen.1003212.s009"><label>Figure S9</label><caption><p>4q32.3 regional association plot using <italic>BRCA1</italic> stage 1 and stage 2 samples. P-values for association (−log<sub>10</sub> scale) with ovarian cancer risk for <italic>BRCA1</italic> mutation carriers for genotyped SNPs (diamond symbols ◊) and imputed SNPs from the 1000 genomes project data (square symbols □), by position (hg18) on chromosome 1. Red gradient represents r<sup>2</sup> value with the most significant genotyped SNP rs4691139. Blue peaks represent recombination rate in the region.</p><p>(PDF)</p></caption><media xlink:href="pgen.1003212.s009.pdf"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pgen.1003212.s010"><label>Figure S10</label><caption><p>Combined Hazard Ratios (HR) for breast and ovarian cancer for <italic>BRCA1</italic> mutation carriers. (A) HR for Breast Cancer based on 10 loci associated with breast cancer risk for <italic>BRCA1</italic> mutation carriers. (B) Ovarian Cancer based on 7 loci associated with ovarian cancer risk for <italic>BRCA1</italic> mutation carriers. All HRs computed relative to the lowest risk category. The Y-axes translate the combined HRs into absolute risks of developing breast or ovarian cancer by age 80. The absolute risks and HRs at different percentiles of the combined genotype distribution are also marked. The combined HRs were obtained under the assumption that the loci interact multiplicatively.</p><p>(PDF)</p></caption><media xlink:href="pgen.1003212.s010.pdf"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pgen.1003212.s011"><label>Figure S11</label><caption><p>Cis-eQTL and allelic expression (AE) analyses at <italic>MDM4</italic> locus. A) Cis-eQTLs for SNPs at <italic>MDM4</italic> locus using expression data from primary human osteoblasts (HOb). B) AE mapping for cis-regulatory variation in <italic>MDM4</italic> locus using primary skin fibroblasts. Coordinates (hg18) for locus shown on top; blue tracks indicate the −log<sub>10</sub>(P value) of the association across all SNPs tested. The location of transcripts in this region is shown below.</p><p>(PDF)</p></caption><media xlink:href="pgen.1003212.s011.pdf"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pgen.1003212.s012"><label>Figure S12</label><caption><p>Cis-eQTL and allelic expression (AE) analyses at chr17q21.31 locus. (Upper panel) Cis-eQTLs for SNPs at c17orf69 locus using expression data from primary human osteoblasts. Allelic expression mapping for cis-regulatory variation in <italic>KANSL1</italic> (middle panel) and <italic>WNT3</italic> loci (lower panel) using a CEU population panel of lymphoblastoid cells. Coordinates (hg18) for loci are shown on top; blue tracks indicate the −log<sub>10</sub>(P value) of the association across all SNPs tested. The location of transcripts in these regions are shown.</p><p>(PDF)</p></caption><media xlink:href="pgen.1003212.s012.pdf"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pgen.1003212.s013"><label>Table S1</label><caption><p>Affected and unaffected <italic>BRCA1</italic> mutation carriers by study country in the breast and ovarian cancer analysis used in SNP selection for the iCOGS array.</p><p>(DOCX)</p></caption><media xlink:href="pgen.1003212.s013.docx"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pgen.1003212.s014"><label>Table S2</label><caption><p>Origin of <italic>BRCA1</italic> samples by Country and Stage used in the current analysis.</p><p>(DOCX)</p></caption><media xlink:href="pgen.1003212.s014.docx"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pgen.1003212.s015"><label>Table S3</label><caption><p>Sample and SNP quality control summary.</p><p>(DOCX)</p></caption><media xlink:href="pgen.1003212.s015.docx"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pgen.1003212.s016"><label>Table S4</label><caption><p>Associations with breast cancer risk for <italic>BRCA1</italic> mutation carriers, for known breast cancer susceptibility variants.</p><p>(DOCX)</p></caption><media xlink:href="pgen.1003212.s016.docx"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pgen.1003212.s017"><label>Table S5</label><caption><p>Associations with <italic>BRCA1</italic> breast or ovarian cancer risk for SNPs genotyped at stages 1, 2, and 3.</p><p>(DOCX)</p></caption><media xlink:href="pgen.1003212.s017.docx"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pgen.1003212.s018"><label>Table S6</label><caption><p>Analysis of breast cancer associations by <italic>BRCA1</italic> mutation class.</p><p>(DOCX)</p></caption><media xlink:href="pgen.1003212.s018.docx"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pgen.1003212.s019"><label>Table S7</label><caption><p>Associations with Breast Cancer ER status in <italic>BRCA1</italic> carriers for SNPs genotyped in stages 1–3.</p><p>(DOCX)</p></caption><media xlink:href="pgen.1003212.s019.docx"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pgen.1003212.s020"><label>Table S8</label><caption><p>Imputed SNPs at the novel 17q21 region with P-values less than the most significant genotyped SNP (rs169201).</p><p>(DOCX)</p></caption><media xlink:href="pgen.1003212.s020.docx"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pgen.1003212.s021"><label>Table S9</label><caption><p>SNPs associated (P<1×10<sup>−5</sup>) with local expression and Allelic Imbalance.</p><p>(DOCX)</p></caption><media xlink:href="pgen.1003212.s021.docx"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pgen.1003212.s022"><label>Text S1</label><caption><p>Supplementary Methods.</p><p>(DOCX)</p></caption><media xlink:href="pgen.1003212.s022.docx"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material></sec></body><back><ack><p>Antonis C. Antoniou is a Cancer Research–UK Senior Cancer Research Fellow. Douglas F. Easton is a Cancer Research UK Principal Research Fellow. Georgia Chenevix-Trench is an NHMRC Senior Principal Research Fellow.</p><p><bold>iCOGS:</bold> CIMBA acknowledges the contributions of Kyriaki Michailidou, Jonathan Tyrer, and Ali Amin Al Olama to the iCOGS statistical analyses; Shahana Ahmed, Melanie J. Maranian, and Catherine S. Healey for their contributions to the iCOGS genotyping quality control process; and the staff of the genotyping unit in the Medical Genomics Facility at the Mayo Clinic under the supervision of Dr. Julie Cunningham.</p><p><bold>Breast Cancer Family Registry (BCFR) Studies:</bold> Samples from the NC-BCFR were processed and distributed by the Coriell Institute for Medical Research. We wish to thank members and participants in the Breast Cancer Family Registry for their contributions to the study. The ABCFS would like to also thank Maggie Angelakos, Judi Maskiell, and Gillian Dite. The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centers in the BCFR, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government or the BCFR.</p><p><bold>Baltic Familial Breast Ovarian Cancer Consortium (BFBOCC):</bold> BFBOCC acknowledges Vilius Rudaitis and Laimonas Griškevičius. BFBOCC-LV acknowledges oncologists Janis Eglitis, Anna Krilova and Aivars Stengrevics.</p><p><bold>BRCA-gene mutations and breast cancer in South African women (BMBSA):</bold> BMBSA thanks the families who contributed to the BMBSA study.</p><p><bold>Beckman Research Institute of the City of Hope (BRICOH):</bold> BRICOH thanks Greg Wilhoite and Marie Pinto for their work in participant enrollment and biospecimen and data management.</p><p><bold>Copenhagen Breast Cancer Study (CBCS):</bold> CBCS thanks the Danish Breast Cancer Cooperative Group (DBCG) for clinical data.</p><p><bold>Spanish National Cancer Centre (CNIO):</bold> CNIO thanks Alicia Barroso, Rosario Alonso and Guillermo Pita for their assistance.</p><p><bold>CONsorzio Studi ITaliani sui Tumori Ereditari Alla Mammella (CONSIT TEAM):</bold> CONSIT TEAM acknowledges Daniela Zaffaroni of the Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Monica Barile of Istituto Europeo di Oncologia (IEO), Milan, Riccardo Dolcetti of the Centro di Riferimento Oncologico (CRO) IRCCS, Aviano (PN), Maurizio Genuardi of University of Florence, Florence, Giuseppe Giannini of “La Sapienza” University, Rome, Adele Patrini of the Ospedale di Circolo-Università dell'Insubria, Varese, Antonella Savarese and Aline Martayain of the Istituto Nazionale Tumori Regina Elena (IRE), Rome and Stefania Tommasi of the Istituto Nazionale Tumori “Giovanni Paolo II”, Bari and the personnel of the CGT-lab at IFOM-IEO Campus, Milan, Italy.</p><p><bold>Dana-Farber Cancer Institute (DFCI):</bold> DFCI thanks the study staff and participants.</p><p><bold>The Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON):</bold> HEBON recognizes Netherlands Cancer Institute, Amsterdam, NL: M.A. Rookus, F.B.L. Hogervorst, S. Verhoef, F.E. van Leeuwen, M.K. Schmidt, J. de Lange; Erasmus Medical Center, Rotterdam, NL: J.M. Collée, A.M.W. van den Ouweland, M.J. Hooning, C. Seynaeve; Leiden University Medical Center, NL: C.J. van Asperen, J.T. Wijnen, R.A. Tollenaar, P. Devilee, T.C.T.E.F. van Cronenburg; Radboud University Nijmegen Medical Center, NL: C.M. Kets, A.R. Mensenkamp; University Medical Center Utrecht, NL: M.G.E.M. Ausems, R.B. van der Luijt; Amsterdam Medical Center, NL: C.M. Aalfs, T.A.M. van Os; VU University Medical Center, Amsterdam, NL: J.J.P. Gille, Q. Waisfisz, H.E.J. Meijers-Heijboer; University Hospital Maastricht, NL: E.B. Gómez-Garcia, M.J. Blok; University Medical Center Groningen, NL: J.C. Oosterwijk, H. van der Hout, M.J. Mourits, G.H. de Bock.</p><p><bold>Epidemiological study of BRCA1 & BRCA2 mutation carriers (EMBRACE):</bold> Douglas F. Easton is the PI of the study. EMBRACE acknowledges the Coordinating Centre, Cambridge: Susan Peock, Debra Frost, Steve Ellis, Elena Fineberg, Radka Platte. North of Scotland Regional Genetics Service, Aberdeen: Zosia Miedzybrodzka, Helen Gregory. Northern Ireland Regional Genetics Service, Belfast: Patrick Morrison, Lisa Jeffers. West Midlands Regional Clinical Genetics Service, Birmingham: Trevor Cole, Kai-ren Ong, Jonathan Hoffman. South West Regional Genetics Service, Bristol: Alan Donaldson, Margaret James. East Anglian Regional Genetics Service, Cambridge: Marc Tischkowitz, Joan Paterson, Amy Taylor. Medical Genetics Services for Wales, Cardiff: Alexandra Murray, Mark T. Rogers, Emma McCann. St James's Hospital, Dublin & National Centre for Medical Genetics, Dublin: M. John Kennedy, David Barton. South East of Scotland Regional Genetics Service, Edinburgh: Mary Porteous, Sarah Drummond. Peninsula Clinical Genetics Service, Exeter: Carole Brewer, Emma Kivuva, Anne Searle, Selina Goodman, Kathryn Hill. West of Scotland Regional Genetics Service, Glasgow: Rosemarie Davidson, Victoria Murday, Nicola Bradshaw, Lesley Snadden, Mark Longmuir, Catherine Watt, Sarah Gibson, Eshika Haque, Ed Tobias, Alexis Duncan. South East Thames Regional Genetics Service, Guy's Hospital London: Louise Izatt, Chris Jacobs, Caroline Langman. North West Thames Regional Genetics Service, Harrow: Huw Dorkins, Angela Brady, Athalie Melville, Kashmir Randhawa. Leicestershire Clinical Genetics Service, Leicester: Julian Barwell. Yorkshire Regional Genetics Service, Leeds: Julian Adlard, Gemma Serra-Feliu. Cheshire & Merseyside Clinical Genetics Service, Liverpool: Ian Ellis, Catherine Houghton. Manchester Regional Genetics Service, Manchester: D Gareth Evans, Fiona Lalloo, Jane Taylor. North East Thames Regional Genetics Service, NE Thames, London: Lucy Side, Alison Male, Cheryl Berlin. Nottingham Centre for Medical Genetics, Nottingham: Jacqueline Eason, Rebecca Collier. Northern Clinical Genetics Service, Newcastle: Fiona Douglas, Oonagh Claber, Irene Jobson. Oxford Regional Genetics Service, Oxford: Lisa Walker, Diane McLeod, Dorothy Halliday, Sarah Durell, Barbara Stayner. The Institute of Cancer Research and Royal Marsden NHS Foundation Trust: Rosalind A. Eeles, Susan Shanley, Nazneen Rahman, Richard Houlston, Astrid Stormorken, Elizabeth Bancroft, Elizabeth Page, Audrey Ardern-Jones, Kelly Kohut, Jennifer Wiggins, Elena Castro, Emma Killick, Sue Martin, Gillian Rea, Anjana Kulkarni. North Trent Clinical Genetics Service, Sheffield: Jackie Cook, Oliver Quarrell, Cathryn Bardsley. South West Thames Regional Genetics Service, London: Shirley Hodgson, Sheila Goff, Glen Brice, Lizzie Winchester, Charlotte Eddy, Vishakha Tripathi, Virginia Attard, Anna Lehmann. Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton: Diana Eccles, Anneke Lucassen, Gillian Crawford, Donna McBride, Sarah Smalley.</p><p><bold>Fox Chase Cancer Canter (FCCC):</bold> FCCC thanks Dr. Betsy Bove for her technical support.</p><p><bold>German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC):</bold> GC-HBOC thanks all family members who participated in this study, Wolfram Heinritz, Center Leipzig, and Dieter Schäfer, Center Frankfurt, for providing DNA samples and Juliane Köhler for excellent technical assistance.</p><p><bold>Genetic Modifiers of Cancer Risk in BRCA1/2 Mutation Carriers (GEMO):</bold> GEMO thanks all the GEMO collaborating groups for their contribution to this study. GEMO Collaborating Centers are: Coordinating Centres, Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard, & Equipe «Génétique du cancer du sein», Centre de Recherche en Cancérologie de Lyon: Olga Sinilnikova, Sylvie Mazoyer, Francesca Damiola, Laure Barjhoux, Carole Verny-Pierre, Sophie Giraud, Mélanie Léone; and Service de Génétique Oncologique, Institut Curie, Paris: Dominique Stoppa-Lyonnet, Marion Gauthier-Villars, Bruno Buecher, Claude Houdayer, Virginie Moncoutier, Muriel Belotti, Carole Tirapo, Antoine de Pauw. Institut Gustave Roussy, Villejuif: Brigitte Bressac-de-Paillerets, Olivier Caron. Centre Jean Perrin, Clermont–Ferrand: Yves-Jean Bignon, Nancy Uhrhammer. Centre Léon Bérard, Lyon: Christine Lasset, Valérie Bonadona, Sandrine Handallou. Centre François Baclesse, Caen: Agnès Hardouin, Pascaline Berthet. Institut Paoli Calmettes, Marseille: Hagay Sobol, Violaine Bourdon, Tetsuro Noguchi, Audrey Remenieras, François Eisinger. CHU Arnaud-de-Villeneuve, Montpellier: Isabelle Coupier, Pascal Pujol. Centre Oscar Lambret, Lille: Jean-Philippe Peyrat, Joëlle Fournier, Françoise Révillion, Philippe Vennin, Claude Adenis. Hôpital René Huguenin/Institut Curie, St Cloud: Etienne Rouleau, Rosette Lidereau, Liliane Demange, Catherine Nogues. Centre Paul Strauss, Strasbourg: Danièle Muller, Jean-Pierre Fricker. Institut Bergonié, Bordeaux: Emmanuelle Barouk-Simonet, Françoise Bonnet, Virginie Bubien, Nicolas Sevenet, Michel Longy. Institut Claudius Regaud, Toulouse: Christine Toulas, Rosine Guimbaud, Laurence Gladieff, Viviane Feillel. CHU Grenoble: Dominique Leroux, Hélène Dreyfus, Christine Rebischung, Magalie Peysselon. CHU Dijon: Fanny Coron, Laurence Faivre. CHU St-Etienne: Fabienne Prieur, Marine Lebrun, Caroline Kientz. Hôtel Dieu Centre Hospitalier, Chambéry: Sandra Fert Ferrer. Centre Antoine Lacassagne, Nice: Marc Frénay. CHU Limoges: Laurence Vénat-Bouvet. CHU Nantes: Capucine Delnatte. CHU Bretonneau, Tours: Isabelle Mortemousque. Groupe Hospitalier Pitié-Salpétrière, Paris: Florence Coulet, Chrystelle Colas, Florent Soubrier. CHU Vandoeuvre-les-Nancy : Johanna Sokolowska, Myriam Bronner. Creighton University, Omaha, USA: Henry T. Lynch, Carrie L. Snyder.</p><p><bold>GFAST:</bold> G-FAST acknowledges the contribution of Bruce Poppe and Anne De Paepe and the technical support of Ilse Coene en Brecht Crombez.</p><p><bold>Hospital Clinico San Carlos (HCSC):</bold> HCSC acknowledges Alicia Tosar for her technical assistance</p><p><bold>Helsinki Breast Cancer Study (HEBCS):</bold> HEBCS thanks Carl Blomqvist, Kirsimari Aaltonen and RN Irja Erkkilä for their help with the HEBCS data and samples.</p><p><bold>Study of Genetic Mutations in Breast and Ovarian Cancer patients in Hong Kong and Asia (HRBCP):</bold> HRBCP thanks Hong Kong Sanatoriuma and Hospital for their continual support.</p><p><bold>Molecular Genetic Studies of Breast and Ovarian Cancer in Hungary (HUNBOCS):</bold> HUNBOCS thanks Hungarian Breast and Ovarian Cancer Study Group members (Janos Papp, Aniko Bozsik, Kristof Arvai, Judit Franko, Maria Balogh, Gabriella Varga, Judit Ferenczi, Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary) and the clinicians and patients for their contributions to this study.</p><p><bold>INterdisciplinary HEalth Research Internal Team BReast CAncer susceptibility (INHERIT):</bold> INHERIT thanks Dr Martine Dumont, Martine Tranchant for sample management and skillful technical assistance. J.S. is Chairholder of the Canada Research Chair in Oncogenetics.</p><p><bold>Kathleen Cuningham Consortium for Research into Familial Breast Cancer (kConFab):</bold> kConFab thanks Heather Thorne, Eveline Niedermayr, all the kConFab research nurses and staff, the heads and staff of the Family Cancer Clinics, and the Clinical Follow Up Study for their contributions to this resource, and the many families who contribute to kConFab.</p><p><bold>Modifier Study of Quantitative Effects on Disease (MODSQUAD):</bold> MODSQUAD acknowledges ModSQuaD members Csilla Szabo and Zohra Ali-Kahn Catts (University of Delaware, Newark, USA); Lenka Foretova and Eva Machackova (Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic); and Michal Zikan, Petr Pohlreich and Zdenek Kleibl (Oncogynecologic Center and Department of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic).</p><p><bold>National Israeli Cancer Control Center (NICCC):</bold> NICCC thanks the NICCC National Familial Cancer Consultation Service team led by Sara Dishon, the laboratory team led by Dr. Flavio Lejbkowicz, and the research field operations team led by Dr. Mila Pinchev.</p><p><bold>Ontario Cancer Genetics Network (OCGN):</bold> OCGN thanks the study staff and participants.</p><p><bold>The Ohio State University Comprehensive Cancer Center (OSUCCG):</bold> OSU CCG acknowledges Kevin Sweet, Caroline Craven and Michelle O'Connor who were instrumental in accrual of study participants, ascertainment of medical records and database management. Samples were processed by the OSU Human Genetics Sample Bank.</p><p><bold>South East Asian Breast Cancer Association Study (SEABASS):</bold> SEABASS thanks Yip Cheng Har, Nur Aishah Mohd Taib, Phuah Sze Yee, Norhashimah Hassan and all the research nurses, research assistants and doctors involved in the MyBrCa Study for assistance in patient recruitment, data collection and sample preparation. In addition, we thank Philip Iau, Sng Jen-Hwei and Sharifah Nor Akmal for contributing samples from the Singapore Breast Cancer Study and the HUKM-HKL Study respectively.</p><p><bold>Sheba Medical Centre (SMC):</bold> SMC acknowledges the assistance of the Meirav Comprehensice breast cancer center team at the Sheba Medical Center for assistance in this study.</p><p><bold>Swedish Breast Cancer Study (SWE-BRCA):</bold> SWE-BRCA Acknowledges SWE-BRCA collaborators from Lund University and University Hospital: Åke Borg, Håkan Olsson, Helena Jernström, Karin Henriksson, Katja Harbst, Maria Soller, Niklas Loman, Ulf Kristoffersson; Gothenburg Sahlgrenska University Hospital: Anna Öfverholm, Margareta Nordling, Per Karlsson, Zakaria Einbeigi; Stockholm and Karolinska University Hospital: Anna von Wachenfeldt, Annelie Liljegren, Annika Lindblom, Brita Arver, Gisela Barbany Bustinza, Johanna Rantala; Umeå University Hospital: Beatrice Melin, Christina Edwinsdotter Ardnor, Monica Emanuelsson; Uppsala University: Hans Ehrencrona, Maritta Hellström Pigg, Richard Rosenquist; Linköping University Hospital: Marie Stenmark-Askmalm, Sigrun Liedgren.</p><p><bold>The University of Chicago Center for Clinical Cancer Genetics and Global Health (UCHICAGO):</bold> UCHICAGO thanks Cecilia Zvocec, Qun Niu, physicians, genetic counselors, research nurses and staff of the Cancer Risk Clinic for their contributions to this resource, and the many families who contribute to our program. OIO is an ACS Clinical Research Professor.</p><p><bold>University of California Los Angeles (UCLA):</bold> UCLA thanks Joyce Seldon MSGC and Lorna Kwan, MPH for assembling the data for this study.</p><p><bold>University of California San Francisco (UCSF):</bold> UCSF thanks Ms. Salina Chan for her data management and the following genetic counselors for participant recruitment: Beth Crawford, Nicola Stewart, Julie Mak, and Kate Lamvik.</p><p><bold>United Kingdom Familial Ovarian Cancer Registries (UKFOCR):</bold> UKFOCR thanks Paul Pharoah, Simon Gayther, Carole Pye, Patricia Harrington and Eva Wozniak for their contributions towards the UKFOCR.</p><p><bold>Victorian Familial Cancer Trials Group (VFCTG):</bold> VFCTG thanks Sarah Sawyer and Rebecca Driessen for assembling this data and Ella Thompson for performing all DNA amplification.</p></ack><ref-list><title>References</title><ref id="pgen.1003212-Antoniou1"><label>1</label><mixed-citation 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