Evidence-based organization and patient safety strategies in European hospitals
Identifieur interne : 002611 ( Pmc/Corpus ); précédent : 002610; suivant : 002612Evidence-based organization and patient safety strategies in European hospitals
Auteurs : Rosa Sunol ; Cordula Wagner ; Onyebuchi A. Arah ; Charles D. Shaw ; Solvejg Kristensen ; Caroline A. Thompson ; Maral Dersarkissian ; Paul D. Bartels ; Holger Pfaff ; Mariona Secanell ; Nuria Mora ; Frantisek Vlcek ; Halina Kutaj-Wasikowska ; Basia Kutryba ; Philippe Michel ; Oliver GroeneSource :
- International Journal for Quality in Health Care [ 1353-4505 ] ; 2014.
Abstract
To explore how European hospitals have implemented patient safety strategies (PSS) and evidence-based organization of care pathway (EBOP) recommendations and examine the extent to which implementation varies between countries and hospitals.
Mixed-method multilevel cross-sectional design in seven countries as part of the European Union-funded project ‘Deepening our Understanding of Quality improvement in Europe’ (DUQuE).
Seventy-four acute care hospitals with 292 departments managing acute myocardial infarction (AMI), hip fracture, stroke, and obstetric deliveries.
Five multi-item composite measures—one generic measure for PSS and four pathway-specific measures for EBOP.
Potassium chloride had only been removed from general medication stocks in 9.4–30.5% of different pathways wards and patients were adequately identified with wristband in 43.0–59.7%. Although 86.3% of areas treating AMI patients had immediate access to a specialist physician, only 56.0% had arrangements for patients to receive thrombolysis within 30 min of arrival at the hospital. A substantial amount of the total variance observed was due to between-hospital differences in the same country for PSS (65.9%). In EBOP, between-country differences play also an important role (10.1% in AMI to 57.1% in hip fracture).
There were substantial gaps between evidence and practice of PSS and EBOP in a sample of European hospitals and variations due to country differences are more important in EBOP than in PSS, but less important than within-country variations. Agencies supporting the implementation of PSS and EBOP should closely re-examine the effectiveness of their current strategies.
Url:
DOI: 10.1093/intqhc/mzu016
PubMed: 24578501
PubMed Central: 4001691
Links to Exploration step
PMC:4001691Le document en format XML
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<author><name sortKey="Secanell, Mariona" sort="Secanell, Mariona" uniqKey="Secanell M" first="Mariona" last="Secanell">Mariona Secanell</name>
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<author><name sortKey="Mora, Nuria" sort="Mora, Nuria" uniqKey="Mora N" first="Nuria" last="Mora">Nuria Mora</name>
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<author><name sortKey="Vlcek, Frantisek" sort="Vlcek, Frantisek" uniqKey="Vlcek F" first="Frantisek" last="Vlcek">Frantisek Vlcek</name>
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<author><name sortKey="Kutaj Wasikowska, Halina" sort="Kutaj Wasikowska, Halina" uniqKey="Kutaj Wasikowska H" first="Halina" last="Kutaj-Wasikowska">Halina Kutaj-Wasikowska</name>
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<author><name sortKey="Michel, Philippe" sort="Michel, Philippe" uniqKey="Michel P" first="Philippe" last="Michel">Philippe Michel</name>
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<author><name sortKey="Groene, Oliver" sort="Groene, Oliver" uniqKey="Groene O" first="Oliver" last="Groene">Oliver Groene</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Evidence-based organization and patient safety strategies in European hospitals</title>
<author><name sortKey="Sunol, Rosa" sort="Sunol, Rosa" uniqKey="Sunol R" first="Rosa" last="Sunol">Rosa Sunol</name>
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,<country>Spain</country>
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<author><name sortKey="Wagner, Cordula" sort="Wagner, Cordula" uniqKey="Wagner C" first="Cordula" last="Wagner">Cordula Wagner</name>
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,<country>The Netherlands</country>
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<affiliation><nlm:aff id="af4"><addr-line>Department of Public and Occupational Health</addr-line>
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,<addr-line>Amsterdam</addr-line>
,<country>The Netherlands</country>
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<author><name sortKey="Arah, Onyebuchi A" sort="Arah, Onyebuchi A" uniqKey="Arah O" first="Onyebuchi A." last="Arah">Onyebuchi A. Arah</name>
<affiliation><nlm:aff id="af5"><addr-line>Department of Epidemiology, Fielding School of Public Health</addr-line>
,<institution>University of California, Los Angeles (UCLA)</institution>
,<addr-line>Los Angeles, CA</addr-line>
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<author><name sortKey="Shaw, Charles D" sort="Shaw, Charles D" uniqKey="Shaw C" first="Charles D." last="Shaw">Charles D. Shaw</name>
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,<country>Australia</country>
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</affiliation>
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<author><name sortKey="Kristensen, Solvejg" sort="Kristensen, Solvejg" uniqKey="Kristensen S" first="Solvejg" last="Kristensen">Solvejg Kristensen</name>
<affiliation><nlm:aff id="af7"><addr-line>Central Denmark Region & Center for Healthcare Improvements</addr-line>
,<institution>Aalborg University</institution>
,<country>Denmark</country>
</nlm:aff>
</affiliation>
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<author><name sortKey="Thompson, Caroline A" sort="Thompson, Caroline A" uniqKey="Thompson C" first="Caroline A." last="Thompson">Caroline A. Thompson</name>
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<author><name sortKey="Dersarkissian, Maral" sort="Dersarkissian, Maral" uniqKey="Dersarkissian M" first="Maral" last="Dersarkissian">Maral Dersarkissian</name>
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<author><name sortKey="Bartels, Paul D" sort="Bartels, Paul D" uniqKey="Bartels P" first="Paul D." last="Bartels">Paul D. Bartels</name>
<affiliation><nlm:aff id="af8"><addr-line>Palo Alto Medical Foundation Research Institute, Palo Alto, CA, USA</addr-line>
</nlm:aff>
</affiliation>
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<author><name sortKey="Pfaff, Holger" sort="Pfaff, Holger" uniqKey="Pfaff H" first="Holger" last="Pfaff">Holger Pfaff</name>
<affiliation><nlm:aff id="af9"><addr-line>Central Denmark Region & The Department of Clinical Medicine</addr-line>
,<institution>Aalborg University</institution>
,<country>Denmark</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Secanell, Mariona" sort="Secanell, Mariona" uniqKey="Secanell M" first="Mariona" last="Secanell">Mariona Secanell</name>
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</nlm:aff>
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,<country>Spain</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mora, Nuria" sort="Mora, Nuria" uniqKey="Mora N" first="Nuria" last="Mora">Nuria Mora</name>
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,<country>Spain</country>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af2"><institution>Red de investigación en servicios de salud en enfermedades crónicas REDISSEC</institution>
,<country>Spain</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vlcek, Frantisek" sort="Vlcek, Frantisek" uniqKey="Vlcek F" first="Frantisek" last="Vlcek">Frantisek Vlcek</name>
<affiliation><nlm:aff id="af10"><addr-line>Institute of Medical Sociology, Health Services Research and Rehabilitation Science</addr-line>
,<institution>University of Cologne</institution>
,<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kutaj Wasikowska, Halina" sort="Kutaj Wasikowska, Halina" uniqKey="Kutaj Wasikowska H" first="Halina" last="Kutaj-Wasikowska">Halina Kutaj-Wasikowska</name>
<affiliation><nlm:aff id="af11"><institution>Czech Accreditation Committee</institution>
,<country>Czech Republic</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kutryba, Basia" sort="Kutryba, Basia" uniqKey="Kutryba B" first="Basia" last="Kutryba">Basia Kutryba</name>
<affiliation><nlm:aff id="af11"><institution>Czech Accreditation Committee</institution>
,<country>Czech Republic</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Michel, Philippe" sort="Michel, Philippe" uniqKey="Michel P" first="Philippe" last="Michel">Philippe Michel</name>
<affiliation><nlm:aff id="af12"><institution>Polish Society for Quality Promotion in Health Care</institution>
,<country>Poland</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Groene, Oliver" sort="Groene, Oliver" uniqKey="Groene O" first="Oliver" last="Groene">Oliver Groene</name>
<affiliation><nlm:aff id="af13"><addr-line>Quality and Safety Department</addr-line>
,<institution>Lyon University, Hospital Network</institution>
,<country>France</country>
</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">International Journal for Quality in Health Care</title>
<idno type="ISSN">1353-4505</idno>
<idno type="eISSN">1464-3677</idno>
<imprint><date when="2014">2014</date>
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<front><div type="abstract" xml:lang="en"><sec><title>Objective</title>
<p>To explore how European hospitals have implemented patient safety strategies (PSS) and evidence-based organization of care pathway (EBOP) recommendations and examine the extent to which implementation varies between countries and hospitals.</p>
</sec>
<sec><title>Design</title>
<p>Mixed-method multilevel cross-sectional design in seven countries as part of the European Union-funded project ‘Deepening our Understanding of Quality improvement in Europe’ (DUQuE).</p>
</sec>
<sec><title>Setting and participants</title>
<p>Seventy-four acute care hospitals with 292 departments managing acute myocardial infarction (AMI), hip fracture, stroke, and obstetric deliveries.</p>
</sec>
<sec><title>Main outcome measure</title>
<p>Five multi-item composite measures—one generic measure for PSS and four pathway-specific measures for EBOP.</p>
</sec>
<sec><title>Results</title>
<p>Potassium chloride had only been removed from general medication stocks in 9.4–30.5% of different pathways wards and patients were adequately identified with wristband in 43.0–59.7%. Although 86.3% of areas treating AMI patients had immediate access to a specialist physician, only 56.0% had arrangements for patients to receive thrombolysis within 30 min of arrival at the hospital. A substantial amount of the total variance observed was due to between-hospital differences in the same country for PSS (65.9%). In EBOP, between-country differences play also an important role (10.1% in AMI to 57.1% in hip fracture).</p>
</sec>
<sec><title>Conclusions</title>
<p>There were substantial gaps between evidence and practice of PSS and EBOP in a sample of European hospitals and variations due to country differences are more important in EBOP than in PSS, but less important than within-country variations. Agencies supporting the implementation of PSS and EBOP should closely re-examine the effectiveness of their current strategies.</p>
</sec>
</div>
</front>
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<biblStruct><analytic><author><name sortKey="Grimshaw, Jm" uniqKey="Grimshaw J">JM Grimshaw</name>
</author>
<author><name sortKey="Shirran, L" uniqKey="Shirran L">L Shirran</name>
</author>
<author><name sortKey="Thomas, R" uniqKey="Thomas R">R Thomas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Groene, O" uniqKey="Groene O">O Groene</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Qual Health Care</journal-id>
<journal-id journal-id-type="iso-abbrev">Int J Qual Health Care</journal-id>
<journal-id journal-id-type="publisher-id">intqhc</journal-id>
<journal-id journal-id-type="hwp">intqhc</journal-id>
<journal-title-group><journal-title>International Journal for Quality in Health Care</journal-title>
</journal-title-group>
<issn pub-type="ppub">1353-4505</issn>
<issn pub-type="epub">1464-3677</issn>
<publisher><publisher-name>Oxford University Press</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24578501</article-id>
<article-id pub-id-type="pmc">4001691</article-id>
<article-id pub-id-type="doi">10.1093/intqhc/mzu016</article-id>
<article-id pub-id-type="publisher-id">mzu016</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Papers</subject>
</subj-group>
</article-categories>
<title-group><article-title>Evidence-based organization and patient safety strategies in European hospitals</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Sunol</surname>
<given-names>Rosa</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
<xref ref-type="aff" rid="af2">2</xref>
<xref ref-type="corresp" rid="cor1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wagner</surname>
<given-names>Cordula</given-names>
</name>
<xref ref-type="aff" rid="af3">3</xref>
<xref ref-type="aff" rid="af4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Arah</surname>
<given-names>Onyebuchi A.</given-names>
</name>
<xref ref-type="aff" rid="af5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shaw</surname>
<given-names>Charles D.</given-names>
</name>
<xref ref-type="aff" rid="af6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kristensen</surname>
<given-names>Solvejg</given-names>
</name>
<xref ref-type="aff" rid="af7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Thompson</surname>
<given-names>Caroline A.</given-names>
</name>
<xref ref-type="aff" rid="af5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dersarkissian</surname>
<given-names>Maral</given-names>
</name>
<xref ref-type="aff" rid="af5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bartels</surname>
<given-names>Paul D.</given-names>
</name>
<xref ref-type="aff" rid="af8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pfaff</surname>
<given-names>Holger</given-names>
</name>
<xref ref-type="aff" rid="af9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Secanell</surname>
<given-names>Mariona</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
<xref ref-type="aff" rid="af2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mora</surname>
<given-names>Nuria</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
<xref ref-type="aff" rid="af2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vlcek</surname>
<given-names>Frantisek</given-names>
</name>
<xref ref-type="aff" rid="af10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kutaj-Wasikowska</surname>
<given-names>Halina</given-names>
</name>
<xref ref-type="aff" rid="af11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kutryba</surname>
<given-names>Basia</given-names>
</name>
<xref ref-type="aff" rid="af11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Michel</surname>
<given-names>Philippe</given-names>
</name>
<xref ref-type="aff" rid="af12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Groene</surname>
<given-names>Oliver</given-names>
</name>
<xref ref-type="aff" rid="af13">13</xref>
</contrib>
<contrib contrib-type="author"><collab>on behalf of the DUQuE Project Consortium</collab>
<xref ref-type="author-notes" rid="AN1">†</xref>
</contrib>
</contrib-group>
<contrib-group><contrib contrib-type="author"><name><surname>Klazinga</surname>
<given-names>N.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Kringos</surname>
<given-names>D.S.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Lombarts</surname>
<given-names>M.J.M.H.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Plochg</surname>
<given-names>T.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Lopez</surname>
<given-names>M.A.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Vallejo</surname>
<given-names>P.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Saillour-Glenisson</surname>
<given-names>F.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Car</surname>
<given-names>M.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Jones</surname>
<given-names>S.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Klaus</surname>
<given-names>E.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Bottaro</surname>
<given-names>S.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Garel</surname>
<given-names>P.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Saluvan</surname>
<given-names>M.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Bruneau</surname>
<given-names>C.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Depaigne-Loth</surname>
<given-names>A.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Hammer</surname>
<given-names>A.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Ommen</surname>
<given-names>O.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Pfaff</surname>
<given-names>H.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Botje</surname>
<given-names>D.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Escoval</surname>
<given-names>A.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Lívio</surname>
<given-names>A.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Eiras</surname>
<given-names>M.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Franca</surname>
<given-names>M.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Leite</surname>
<given-names>I.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Almeman</surname>
<given-names>F.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Kus</surname>
<given-names>H.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Ozturk</surname>
<given-names>K.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Mannion</surname>
<given-names>R.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>A.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Thompson</surname>
<given-names>A.</given-names>
</name>
</contrib>
</contrib-group>
<aff id="af1"><label>1</label>
<institution>Avedis Donabedian Research Institute (FAD), Universitat Autonoma de Barcelona</institution>
,<country>Spain</country>
</aff>
<aff id="af2"><label>2</label>
<institution>Red de investigación en servicios de salud en enfermedades crónicas REDISSEC</institution>
,<country>Spain</country>
</aff>
<aff id="af3"><label>3</label>
<institution>NIVEL Netherlands Institute for Health Services Research</institution>
,<addr-line>Utrecht</addr-line>
,<country>The Netherlands</country>
</aff>
<aff id="af4"><label>4</label>
<addr-line>Department of Public and Occupational Health</addr-line>
,<institution>EMGO+ Institute for Health and Care Research</institution>
,<institution>VU University Medical Center</institution>
,<addr-line>Amsterdam</addr-line>
,<country>The Netherlands</country>
</aff>
<aff id="af5"><label>5</label>
<addr-line>Department of Epidemiology, Fielding School of Public Health</addr-line>
,<institution>University of California, Los Angeles (UCLA)</institution>
,<addr-line>Los Angeles, CA</addr-line>
,<country>USA</country>
</aff>
<aff id="af6"><label>6</label>
<institution>University of New South Wales</institution>
,<country>Australia</country>
</aff>
<aff id="af7"><label>7</label>
<addr-line>Central Denmark Region & Center for Healthcare Improvements</addr-line>
,<institution>Aalborg University</institution>
,<country>Denmark</country>
</aff>
<aff id="af8"><label>8</label>
<addr-line>Palo Alto Medical Foundation Research Institute, Palo Alto, CA, USA</addr-line>
</aff>
<aff id="af9"><label>9</label>
<addr-line>Central Denmark Region & The Department of Clinical Medicine</addr-line>
,<institution>Aalborg University</institution>
,<country>Denmark</country>
</aff>
<aff id="af10"><label>10</label>
<addr-line>Institute of Medical Sociology, Health Services Research and Rehabilitation Science</addr-line>
,<institution>University of Cologne</institution>
,<country>Germany</country>
</aff>
<aff id="af11"><label>11</label>
<institution>Czech Accreditation Committee</institution>
,<country>Czech Republic</country>
</aff>
<aff id="af12"><label>12</label>
<institution>Polish Society for Quality Promotion in Health Care</institution>
,<country>Poland</country>
</aff>
<aff id="af13"><label>13</label>
<addr-line>Quality and Safety Department</addr-line>
,<institution>Lyon University, Hospital Network</institution>
,<country>France</country>
</aff>
<aff id="af14"><label>14</label>
<institution>London School of Hygiene and Tropical Medicine</institution>
,<country>UK</country>
</aff>
<author-notes><corresp id="cor1">Address reprint requests to: Rosa Sunol, Avedis Donabedian Research Institute (FAD), Universitat Autonoma de Barcelona, C/Provenza 293 pral, 08037 Barcelona, Spain. Fax: +<fax>34-93-459-38-64</fax>
; E-mail: <email>rsunol@fadq.org</email>
; <email>fad@fadq.org</email>
</corresp>
<fn id="AN1"><label>†</label>
<p>The authors and the DUQuE consortium are given in the Appendix.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><month>4</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>26</day>
<month>2</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>26</day>
<month>2</month>
<year>2014</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
. </pmc-comment>
<volume>26</volume>
<issue>Suppl 1</issue>
<issue-title>How does Hospital Quality Management Drive Quality? Results from the Deepening our Understanding of Quality Improvement (DUQuE) project</issue-title>
<fpage>47</fpage>
<lpage>55</lpage>
<history><date date-type="accepted"><day>23</day>
<month>1</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>© The Author 2014. Published by Oxford University Press in association with the International Society for Quality in Health Care.</copyright-statement>
<copyright-year>2014</copyright-year>
<license license-type="creative-commons" xlink:href="http://creativecommons.org/licenses/by/3.0/"><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/3.0/">http://creativecommons.org/licenses/by/3.0/</ext-link>
), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="mzu016.pdf"></self-uri>
<abstract><sec><title>Objective</title>
<p>To explore how European hospitals have implemented patient safety strategies (PSS) and evidence-based organization of care pathway (EBOP) recommendations and examine the extent to which implementation varies between countries and hospitals.</p>
</sec>
<sec><title>Design</title>
<p>Mixed-method multilevel cross-sectional design in seven countries as part of the European Union-funded project ‘Deepening our Understanding of Quality improvement in Europe’ (DUQuE).</p>
</sec>
<sec><title>Setting and participants</title>
<p>Seventy-four acute care hospitals with 292 departments managing acute myocardial infarction (AMI), hip fracture, stroke, and obstetric deliveries.</p>
</sec>
<sec><title>Main outcome measure</title>
<p>Five multi-item composite measures—one generic measure for PSS and four pathway-specific measures for EBOP.</p>
</sec>
<sec><title>Results</title>
<p>Potassium chloride had only been removed from general medication stocks in 9.4–30.5% of different pathways wards and patients were adequately identified with wristband in 43.0–59.7%. Although 86.3% of areas treating AMI patients had immediate access to a specialist physician, only 56.0% had arrangements for patients to receive thrombolysis within 30 min of arrival at the hospital. A substantial amount of the total variance observed was due to between-hospital differences in the same country for PSS (65.9%). In EBOP, between-country differences play also an important role (10.1% in AMI to 57.1% in hip fracture).</p>
</sec>
<sec><title>Conclusions</title>
<p>There were substantial gaps between evidence and practice of PSS and EBOP in a sample of European hospitals and variations due to country differences are more important in EBOP than in PSS, but less important than within-country variations. Agencies supporting the implementation of PSS and EBOP should closely re-examine the effectiveness of their current strategies.</p>
</sec>
</abstract>
<kwd-group><kwd>patient safety</kwd>
<kwd>quality improvement</kwd>
<kwd>quality management</kwd>
<kwd>practice variations</kwd>
<kwd>appropriate healthcare</kwd>
<kwd>hospital care</kwd>
<kwd>effectiveness</kwd>
</kwd-group>
</article-meta>
</front>
<body><sec sec-type="intro" id="s1"><title>Introduction</title>
<p>Evidence-based medicine and the implementation of patient safety recommendations are considered two of the cornerstones for improving clinical care outcomes [<xref rid="MZU016C1" ref-type="bibr">1</xref>
]. Agencies such as the National Institute for Health Care and Excellence (NICE) and the Scottish Intercollegiate Guidelines Network (SIGN) in the UK and the French Haute Autorité de Santé (HAS) have long-standing clinical pathway guidelines including measures and descriptors for the delivery of high-quality care based on the implementation of evidence-based clinical recommendations and organizational practices [<xref rid="MZU016C2" ref-type="bibr">2</xref>
–<xref rid="MZU016C4" ref-type="bibr">4</xref>
], such as access to 24/7 diagnostic and intervention facilities and systems for triage and transfer to a specialist unit.</p>
<p>International patient safety efforts include the Global Patient Safety Alliance launched by the World Health Organization (WHO) and the Health Care Quality Indicator Project led by the Organization for Economic Co-operation and Development (OECD) [<xref rid="MZU016C5" ref-type="bibr">5</xref>
]. In Europe, the Safety Improvement for Patients in Europe (SImPatIE) project established a common European vocabulary and set of indicators and internal and external instruments to improve safety in healthcare [<xref rid="MZU016C6" ref-type="bibr">6</xref>
] and the European Network for Patient Safety (EUNetPaS) created an umbrella network of all European Union (EU) member states and stakeholders to enhance collaboration in the field of patient safety [<xref rid="MZU016C7" ref-type="bibr">7</xref>
]. Currently, the joint action on Patient Safety and Quality of Care is identifying activities and tools for mutual learning among all EU member states [<xref rid="MZU016C8" ref-type="bibr">8</xref>
].</p>
<p>In recent decades, clinical managers have sought to adopt the above recommendations and improve patient care through system design, guidelines and protocols, adverse event (AE) reporting, and risk management. There is, however, limited evidence that the efforts undertaken have led to significant improvements in compliance with evidence-based medicine or reduction in AEs [<xref rid="MZU016C9" ref-type="bibr">9</xref>
–<xref rid="MZU016C12" ref-type="bibr">12</xref>
]. Another concern is the scarcity of information on the implementation of patient safety strategies (PSS) and evidence-based organization of pathways (EBOP) in European hospitals. Compliance with these best practices in EU countries is also an important policy issue as the recent EU directive on cross-border healthcare reinforces the rights of citizens to seek care in another member state [<xref rid="MZU016C13" ref-type="bibr">13</xref>
].</p>
<p>Our objectives are to describe the implementation of PSS and EBOP in a sample of European hospitals and to explore the extent to which individual countries, hospitals, and department level effects explain the variations observed.</p>
</sec>
<sec sec-type="methods" id="s2"><title>Methods</title>
<sec id="s2a"><title>Setting</title>
<p>This study was conducted as part of the Deepening our Understanding of Quality improvement in Europe (DUQuE) research project, whose conceptual framework and design is detailed elsewhere [<xref rid="MZU016C14" ref-type="bibr">14</xref>
]. We performed a cross-sectional, multilevel study in which patient-level measurements are nested in hospital departments, which, in turn, are nested in hospitals in seven European countries (Czech Republic, France, Germany, Poland, Portugal, Spain, and Turkey). Thirty hospitals were randomly selected in each country and of these, 12 were selected, also randomly, for comprehensive data collection at department and patient level (maximum of 84 hospitals). Pathway and patient-level data were collected for four areas: acute myocardial infarction (AMI), obstetric deliveries, hip fracture, and stroke. Ethical approval was obtained from the Bioethics Committee of the Catalan Health Department (Spain) and each country complied with confidentiality issues according to national legislation or country-specific standards of practice.</p>
</sec>
<sec id="s2b"><title>Measures used in the analysis</title>
<p>PSS were identified through a mapping process of patient safety recommendations drawn from the WHO High 5s project [<xref rid="MZU016C15" ref-type="bibr">15</xref>
], the Joint Commission International Patient Safety Goals [<xref rid="MZU016C16" ref-type="bibr">16</xref>
], Required Organizational Practices from Accreditation Canada [<xref rid="MZU016C17" ref-type="bibr">17</xref>
], and guidelines from intergovernmental organizations such as the Council of Europe [<xref rid="MZU016C18" ref-type="bibr">18</xref>
], the Council of the European Union [<xref rid="MZU016C19" ref-type="bibr">19</xref>
], and the WHO (World Alliance on Patient Safety program) [<xref rid="MZU016C20" ref-type="bibr">20</xref>
]. Selection of PSS was based on the frequency of mention in the reviewed documents and coverage of key safety areas (infection control, medication, life support, AE reporting systems, and security). Selection was also based on the underlying evidence that a patient safety practice prevents or reduces AEs. Eleven PSS items were analyzed. Nine were common to the four pathways (elimination of potassium chloride concentrate from ward stocks, use of wristband identification, needle disposal boxes, hand hygiene promotion/reminders, alcohol-based hand rubs, resuscitation flow charts, crash carts, AE reporting systems, use of AE reports in department quality of care evaluations) and two were specific to obstetric deliveries (neonate identification and secure nursery access). We decided not to analyze safe injection practices as this recommendation was considered to be generally implemented in the countries analyzed. EBOP items were derived from NICE quality standards and SIGN audit tools for the areas relevant to our study [<xref rid="MZU016C21" ref-type="bibr">21</xref>
–<xref rid="MZU016C24" ref-type="bibr">24</xref>
]. Although specific EBOP recommendations differed for the four areas, they followed a generic care pathway design and included items related to admission, acute care, rehabilitation (where appropriate), and discharge. The final measures included 5–10 pathway-specific items (Tables <xref ref-type="table" rid="MZU016TB3">3</xref>
and <xref ref-type="table" rid="MZU016TB4">4</xref>
) [<xref rid="MZU016C25" ref-type="bibr">25</xref>
]. We assumed that hospital characteristics (size, ownership, and teaching status) and extent of implementation of quality management (QM) systems at hospital level could influence the implementation of PSS and EBOP at department level. In the DUQuE project, hospital-level QM systems are assessed using three measures: the QM Systems Index (QMSI) (having QM systems in place), the QM Compliance Index (QMCI) (compliance with Plan-Do-Check/Study-Act cycle), and the Clinical Quality Implementation Index (CQII). The validation and results of these measures are reported elsewhere [<xref rid="MZU016C26" ref-type="bibr">26</xref>
, <xref rid="MZU016C27" ref-type="bibr">27</xref>
].</p>
</sec>
<sec id="s2c"><title>Data collection</title>
<p>Data on PSS, EBOP, QMSI, and CQII were gathered during a 1.5-day onsite audit with visits to all clinical areas, including emergency rooms, contemplated in this study. The audits were performed by external auditors (14 in total) with experience in quality and safety management and hospital accreditation and no relationship with the hospital in question. A centralized ‘teach the teacher’ session was carried out with leading auditors to unify the implementation of the external assessment tool. Training included theoretical and practical information, instructions on the main aspects to be assessed, and scoring guidance.</p>
<p>All items included in PSS and EBOP were assessed by direct observation and rated on a five-point-Likert scale ranging from ‘no or negligible compliance’ (score 0) to ‘full compliance’ (score 4). Explicit criteria were developed to rank each of these positions for each item. Data were collected between May 2011 and February 2012.</p>
</sec>
<sec id="s2d"><title>Statistical analysis</title>
<p>We used univariate and bivariate statistics to report the implementation of PSS and EBOP. Descriptive tables show the number and percentage of departments rated as fully compliant (≥90%) for each item. In order to report the country range for each item, we calculated the percentage of hospitals in each country reported being fully compliant for each item. The country range shows the minimum and maximum of this value across the seven countries included in our analysis. We computed an overall score from the mean score for all items on each specific scale to be used in the multilevel regression models.</p>
<p>We used multivariable adjusted linear mixed models to decompose the outcome variance for PSS and EBOP at each pathway. The model for PSS included two random intercepts for country and hospitals nested within country to account for clustering of hospitals within countries and clustering of the four pathways within hospitals. This allowed us to estimate between-country, between-hospital, and within-hospital variances. The PSS model also included fixed effects for pathway, hospital characteristics (ownership, hospital size, and teaching status), and QM measures at hospital level (QMSI, QMCI, and CQII). A second set of models stratified by pathway were also used to estimate the contribution of between-country and within-country variances to the total variance of EBOP. These models included a random intercept by country to account for clustering of hospitals within countries and fixed effects for hospital characteristics (ownership, hospital size, and teaching status) and QM measures at hospital level (QMSI, QMCI, and CQII). These statistical analyses were carried out in SAS (version 9.3, SAS Institute Inc., NC, USA, 2001) [<xref rid="MZU016C28" ref-type="bibr">28</xref>
].</p>
</sec>
</sec>
<sec sec-type="results" id="s3"><title>Results</title>
<p>Seventy-four hospitals from seven countries provided valid data. We analyzed 292 pathways. The hospital and pathway characteristics are shown in Table <xref ref-type="table" rid="MZU016TB1">1</xref>
.
<table-wrap id="MZU016TB1" position="float"><label>Table 1</label>
<caption><p>Characteristics of hospitals by care pathway</p>
</caption>
<table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col>
<col align="char" char=" " span="1"></col>
<col align="char" char=" " span="1"></col>
<col align="char" char=" " span="1"></col>
<col align="char" char=" " span="1"></col>
</colgroup>
<thead><tr><th align="left" rowspan="2" colspan="1"> </th>
<th align="left" rowspan="1" colspan="1">AMI (<italic>n</italic>
= 72)</th>
<th align="left" rowspan="1" colspan="1">Obstetric deliveries (<italic>n</italic>
= 72)</th>
<th align="left" rowspan="1" colspan="1">Hip fracture (<italic>n</italic>
= 74)</th>
<th align="left" rowspan="1" colspan="1">Stroke (<italic>n</italic>
= 74)</th>
</tr>
<tr><th align="left" rowspan="1" colspan="1"><italic>n</italic>
(%)</th>
<th align="left" rowspan="1" colspan="1"><italic>n</italic>
(%)</th>
<th align="left" rowspan="1" colspan="1"><italic>n</italic>
(%)</th>
<th align="left" rowspan="1" colspan="1"><italic>n</italic>
(%)</th>
</tr>
</thead>
<tbody><tr><td colspan="5" rowspan="1">Teaching hospital</td>
</tr>
<tr><td rowspan="1" colspan="1"> Yes</td>
<td rowspan="1" colspan="1">32 (44.4)</td>
<td rowspan="1" colspan="1">33 (45.8)</td>
<td rowspan="1" colspan="1">33 (44.5)</td>
<td rowspan="1" colspan="1">33 (44.5)</td>
</tr>
<tr><td rowspan="1" colspan="1"> No</td>
<td rowspan="1" colspan="1">40 (55.5)</td>
<td rowspan="1" colspan="1">39 (54.1)</td>
<td rowspan="1" colspan="1">41 (55.4)</td>
<td rowspan="1" colspan="1">41 (55.4)</td>
</tr>
<tr><td colspan="5" rowspan="1">Ownership</td>
</tr>
<tr><td rowspan="1" colspan="1"> Public</td>
<td rowspan="1" colspan="1">59 (81.9)</td>
<td rowspan="1" colspan="1">58 (80.5)</td>
<td rowspan="1" colspan="1">59 (79.7)</td>
<td rowspan="1" colspan="1">59 (79.7)</td>
</tr>
<tr><td rowspan="1" colspan="1"> Private or mixed</td>
<td rowspan="1" colspan="1">13 (18.0)</td>
<td rowspan="1" colspan="1">14 (19.4)</td>
<td rowspan="1" colspan="1">15 (20.2)</td>
<td rowspan="1" colspan="1">15 (20.2)</td>
</tr>
<tr><td colspan="5" rowspan="1">Number of beds</td>
</tr>
<tr><td rowspan="1" colspan="1"> <200</td>
<td rowspan="1" colspan="1">7 (9.7)</td>
<td rowspan="1" colspan="1">6 (8.3)</td>
<td rowspan="1" colspan="1">7 (9.4)</td>
<td rowspan="1" colspan="1">7 (9.4)</td>
</tr>
<tr><td rowspan="1" colspan="1"> 200–500</td>
<td rowspan="1" colspan="1">21 (29.1)</td>
<td rowspan="1" colspan="1">22 (30.5)</td>
<td rowspan="1" colspan="1">22 (29.7)</td>
<td rowspan="1" colspan="1">22 (29.7)</td>
</tr>
<tr><td rowspan="1" colspan="1"> 500–1000</td>
<td rowspan="1" colspan="1">30 (41.6)</td>
<td rowspan="1" colspan="1">31 (43.0)</td>
<td rowspan="1" colspan="1">31 (41.8)</td>
<td rowspan="1" colspan="1">31 (41.8)</td>
</tr>
<tr><td rowspan="1" colspan="1"> >1000</td>
<td rowspan="1" colspan="1">14 (19.4)</td>
<td rowspan="1" colspan="1">13 (18.0)</td>
<td rowspan="1" colspan="1">14 (18.9)</td>
<td rowspan="1" colspan="1">14 (18.9)</td>
</tr>
<tr><td colspan="5" rowspan="1">Teaching department status</td>
</tr>
<tr><td rowspan="1" colspan="1"> Yes</td>
<td rowspan="1" colspan="1">39 (54.1)</td>
<td rowspan="1" colspan="1">42</td>
<td rowspan="1" colspan="1">45 (60.8)</td>
<td rowspan="1" colspan="1">40 (54.0)</td>
</tr>
<tr><td rowspan="1" colspan="1"> No</td>
<td rowspan="1" colspan="1">33 (45.8)</td>
<td rowspan="1" colspan="1">30</td>
<td rowspan="1" colspan="1">29 (39.1)</td>
<td rowspan="1" colspan="1">34 (45.9)</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn><p>AMI, acute myocardial infarction.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</p>
<p>Table <xref ref-type="table" rid="MZU016TB2">2</xref>
shows compliance with PSS by department together with the average country range for each item. Over 90% of patients were identified by wristband in 43.0% of AMI wards (31/72), compared with 59.7% of maternity wards (43/72). No significant differences between-department were observed for compliance with patient identification recommendations, but the differences between country averages were substantial, with figures ranging from 0 to 91.7%. Recommendations such as the use of needle disposal boxes and alcohol-based rubs were met in over 85% of all departments, and the variability between countries was lower (66.7–100.0%). Over two-thirds of maternity wards still had potassium chloride concentrate in their medication stocks, and the figures were even higher in the other departments. AE reporting systems were available in just one-third of the departments audited and reports were used for quality of care evaluations in just half of these.
<table-wrap id="MZU016TB2" position="float"><label>Table 2</label>
<caption><p>Compliance with PSS by department and country ranges<sup>a</sup>
</p>
</caption>
<table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col>
<col align="char" char=" " span="1"></col>
<col align="char" char="." span="1"></col>
<col align="char" char=" " span="1"></col>
<col align="char" char="." span="1"></col>
<col align="char" char=" " span="1"></col>
<col align="char" char="." span="1"></col>
<col align="char" char=" " span="1"></col>
<col align="char" char="." span="1"></col>
<col align="char" char="." span="1"></col>
</colgroup>
<thead><tr><th align="left" rowspan="2" colspan="1"> </th>
<th align="left" rowspan="1" colspan="1">AMI (<italic>n</italic>
= 72)</th>
<th align="left" rowspan="1" colspan="1">Country range</th>
<th align="left" rowspan="1" colspan="1">Obstetric deliveries (<italic>n</italic>
= 72)</th>
<th align="left" rowspan="1" colspan="1">Country range</th>
<th align="left" rowspan="1" colspan="1">Hip (<italic>n</italic>
= 74)</th>
<th align="left" rowspan="1" colspan="1">Country range</th>
<th align="left" rowspan="1" colspan="1">Stroke (<italic>n</italic>
= 74)</th>
<th align="left" rowspan="1" colspan="1">Average country range</th>
<th align="left" rowspan="2" colspan="1"><italic>P</italic>
-value<sup>b</sup>
</th>
</tr>
<tr><th align="left" rowspan="1" colspan="1"><italic>n</italic>
(%)</th>
<th align="left" rowspan="1" colspan="1">%</th>
<th align="left" rowspan="1" colspan="1"><italic>n</italic>
(%)</th>
<th rowspan="1" colspan="1"></th>
<th align="left" rowspan="1" colspan="1"><italic>n</italic>
(%)</th>
<th align="left" rowspan="1" colspan="1">%</th>
<th align="left" rowspan="1" colspan="1"><italic>n</italic>
(%)</th>
<th align="left" rowspan="1" colspan="1">%</th>
</tr>
</thead>
<tbody><tr><td rowspan="1" colspan="1">Patient wristbands</td>
<td rowspan="1" colspan="1">31 (43.0)</td>
<td rowspan="1" colspan="1">25.0–63.6</td>
<td rowspan="1" colspan="1">43 (59.7)</td>
<td rowspan="1" colspan="1">0.0–90.9</td>
<td rowspan="1" colspan="1">37 (50.0)</td>
<td rowspan="1" colspan="1">25.0–75.0</td>
<td rowspan="1" colspan="1">41 (55.4)</td>
<td rowspan="1" colspan="1">25.0–91.7</td>
<td rowspan="1" colspan="1">0.2131</td>
</tr>
<tr><td rowspan="1" colspan="1">Needle disposal boxes</td>
<td rowspan="1" colspan="1">65 (90.2)</td>
<td rowspan="1" colspan="1">75.0–100.0</td>
<td rowspan="1" colspan="1">67 (93.0)</td>
<td rowspan="1" colspan="1">75.0–100.0</td>
<td rowspan="1" colspan="1">66 (89.1)</td>
<td rowspan="1" colspan="1">66.7–100.0</td>
<td rowspan="1" colspan="1">65 (87.8)</td>
<td rowspan="1" colspan="1">66.7–100.0</td>
<td rowspan="1" colspan="1">0.7537</td>
</tr>
<tr><td rowspan="1" colspan="1">Hand hygiene promotion/reminder</td>
<td rowspan="1" colspan="1">55 (76.3)</td>
<td rowspan="1" colspan="1">54.6–100.0</td>
<td rowspan="1" colspan="1">53 (73.6)</td>
<td rowspan="1" colspan="1">54.6–100.0</td>
<td rowspan="1" colspan="1">53 (71.6)</td>
<td rowspan="1" colspan="1">58.3–83.3</td>
<td rowspan="1" colspan="1">50 (67.5)</td>
<td rowspan="1" colspan="1">50.0–91.7</td>
<td rowspan="1" colspan="1">0.6809</td>
</tr>
<tr><td rowspan="1" colspan="1">Alcohol-based hand rubs</td>
<td rowspan="1" colspan="1">65 (90.2)</td>
<td rowspan="1" colspan="1">75.0–100.0</td>
<td rowspan="1" colspan="1">65 (90.2)</td>
<td rowspan="1" colspan="1">66.7–100</td>
<td rowspan="1" colspan="1">66 (89.1)</td>
<td rowspan="1" colspan="1">75.0–100.0</td>
<td rowspan="1" colspan="1">68 (91.8)</td>
<td rowspan="1" colspan="1">75.0–100.0</td>
<td rowspan="1" colspan="1">0.9567</td>
</tr>
<tr><td rowspan="1" colspan="1">No potassium chloride concentrate in patient services areas</td>
<td rowspan="1" colspan="1">11 (15.2)</td>
<td rowspan="1" colspan="1">0.0–50.0</td>
<td rowspan="1" colspan="1">22 (30.5)</td>
<td rowspan="1" colspan="1">8.3–50.0</td>
<td rowspan="1" colspan="1">7 (9.4)</td>
<td rowspan="1" colspan="1">0.0–41.7</td>
<td rowspan="1" colspan="1">8 (10.8)</td>
<td rowspan="1" colspan="1">0.0–41.7</td>
<td rowspan="1" colspan="1">0.0020</td>
</tr>
<tr><td rowspan="1" colspan="1">Resuscitation flow charts</td>
<td rowspan="1" colspan="1">14 (19.4)</td>
<td rowspan="1" colspan="1">0.0–100.0</td>
<td rowspan="1" colspan="1">11 (15.2)</td>
<td rowspan="1" colspan="1">0.0–75.0</td>
<td rowspan="1" colspan="1">10 (13.5)</td>
<td rowspan="1" colspan="1">0.0–75.0</td>
<td rowspan="1" colspan="1">10 (13.5)</td>
<td rowspan="1" colspan="1">0.0–50.0</td>
<td rowspan="1" colspan="1">0.7272</td>
</tr>
<tr><td rowspan="1" colspan="1">Crash cart</td>
<td rowspan="1" colspan="1">40 (55.5)</td>
<td rowspan="1" colspan="1">0.0–90.9</td>
<td rowspan="1" colspan="1">37 (51.3)</td>
<td rowspan="1" colspan="1">8.3–83.3</td>
<td rowspan="1" colspan="1">34 (45.9)</td>
<td rowspan="1" colspan="1">0.0–75.0</td>
<td rowspan="1" colspan="1">37 (50.0)</td>
<td rowspan="1" colspan="1">0.0–81.8</td>
<td rowspan="1" colspan="1">0.7111</td>
</tr>
<tr><td rowspan="1" colspan="1">Adverse event reporting system</td>
<td rowspan="1" colspan="1">25 (34.7)</td>
<td rowspan="1" colspan="1">8.3–75.0</td>
<td rowspan="1" colspan="1">23 (31.9)</td>
<td rowspan="1" colspan="1">16.7–75.0</td>
<td rowspan="1" colspan="1">22 (29.7)</td>
<td rowspan="1" colspan="1">0.0–54.6</td>
<td rowspan="1" colspan="1">22 (29.7)</td>
<td rowspan="1" colspan="1">0.0–75.0</td>
<td rowspan="1" colspan="1">0.9037</td>
</tr>
<tr><td rowspan="1" colspan="1">Adverse event reports used for quality of care evaluations</td>
<td rowspan="1" colspan="1">11 (15.2)</td>
<td rowspan="1" colspan="1">0.0–25.0</td>
<td rowspan="1" colspan="1">20 (27.7)</td>
<td rowspan="1" colspan="1">8.3–75.0</td>
<td rowspan="1" colspan="1">9 (12.1)</td>
<td rowspan="1" colspan="1">8.3–50</td>
<td rowspan="1" colspan="1">12 (16.2)</td>
<td rowspan="1" colspan="1">0.0–33.3</td>
<td rowspan="1" colspan="1">0.0737</td>
</tr>
<tr><td rowspan="1" colspan="1">Overall score, mean (SD)</td>
<td colspan="2" align="left" rowspan="1">2.6 (0.5)</td>
<td colspan="2" align="left" rowspan="1">2.7 (0.6)</td>
<td colspan="2" align="left" rowspan="1">2.5 (0.5)</td>
<td colspan="2" align="left" rowspan="1">2.5 (0.6)</td>
<td rowspan="1" colspan="1"></td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn><p><sup>a</sup>
Compliance is shown by number (%) of departments reporting full compliance; country ranges show minimum–maximum compliance rates (%) based on country averages.</p>
</fn>
<fn><p><sup>b</sup>
<italic>P</italic>
-value for differences in items across pathways (<italic>χ</italic>
<sup>2</sup>
test).</p>
</fn>
</table-wrap-foot>
</table-wrap>
</p>
<p>Tables <xref ref-type="table" rid="MZU016TB3">3</xref>
and <xref ref-type="table" rid="MZU016TB4">4</xref>
show results for EBOP. Although a high proportion of areas treating AMI patients (83.6%; country range, 66.7–100%) have immediate, around-the-clock access to a specialist physician to assess the need for coronary revascularization, only 56.0% (country range, 18.2–85.7%) have arrangements for patients to receive thrombolysis within 30 min of arrival at the hospital.
<table-wrap id="MZU016TB3" position="float"><label>Table 3</label>
<caption><p>Compliance with evidence-based organization of care pathway recommendations for AMI and stroke<sup>a</sup>
</p>
</caption>
<table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col>
<col align="left" span="1"></col>
<col align="char" char="." span="1"></col>
</colgroup>
<thead><tr><th align="left" rowspan="1" colspan="1">Item</th>
<th align="left" rowspan="1" colspan="1"><italic>n</italic>
(%), full compliance</th>
<th align="left" rowspan="1" colspan="1">Average country range<sup>a</sup>
(%)</th>
</tr>
</thead>
<tbody><tr><td colspan="3" rowspan="1">Acute myocardial infarction departments (<italic>n</italic>
= 66)</td>
</tr>
<tr><td rowspan="1" colspan="1"> 1. There are written criteria and procedures for fast-track admission and treatment of patients presenting with acute chest pain</td>
<td rowspan="1" colspan="1">36 (54.5)</td>
<td rowspan="1" colspan="1">18.2–90.9</td>
</tr>
<tr><td rowspan="1" colspan="1"> 2. Arrangements ensure that eligible STEMI (S-T elevation Myocardial Infarction) patients can receive thrombolysis within 30 min of arrival at the hospital</td>
<td rowspan="1" colspan="1">37 (56.0)</td>
<td rowspan="1" colspan="1">18.2–85.7</td>
</tr>
<tr><td rowspan="1" colspan="1"> 3. Immediate access is available 24/7 to a specialist physician to determine whether coronary revascularization is appropriate</td>
<td rowspan="1" colspan="1">57 (86.3)</td>
<td rowspan="1" colspan="1">66.7–100.0</td>
</tr>
<tr><td rowspan="1" colspan="1"> 4. Facilities are immediately available for performance of and transport for emergency coronary angiography</td>
<td rowspan="1" colspan="1">48 (72.7)</td>
<td rowspan="1" colspan="1">40.0–90.9</td>
</tr>
<tr><td rowspan="1" colspan="1"> 5. Facilities are immediately available for performance of and transport for percutaneous coronary intervention</td>
<td rowspan="1" colspan="1">44 (66.6)</td>
<td rowspan="1" colspan="1">36.4–81.8</td>
</tr>
<tr><td rowspan="1" colspan="1">Overall score, mean (SD)</td>
<td rowspan="1" colspan="1">3.2 (0.9)</td>
<td rowspan="1" colspan="1"></td>
</tr>
<tr><td colspan="3" rowspan="1">Stroke departments (<italic>n</italic>
= 74)</td>
</tr>
<tr><td rowspan="1" colspan="1"> 1. There is an agreed procedure for appropriate patients to be directly transported by ambulance personnel to a stroke unit</td>
<td rowspan="1" colspan="1">42 (56.7)</td>
<td rowspan="1" colspan="1">36.4–100.0</td>
</tr>
<tr><td rowspan="1" colspan="1"> 2. Agreed procedures ensure that patients with suspected stroke are assessed for receiving thrombolysis, if clinically indicated</td>
<td rowspan="1" colspan="1">55 (74.3)</td>
<td rowspan="1" colspan="1">41.7–100.0</td>
</tr>
<tr><td rowspan="1" colspan="1"> 3. A thrombolysis service is available 7 days a week in the hospital or by formal arrangement elsewhere</td>
<td rowspan="1" colspan="1">62 (83.7)</td>
<td rowspan="1" colspan="1">58.3–100.0</td>
</tr>
<tr><td rowspan="1" colspan="1"> 4. Agreed procedures ensure that patients with acute stroke have their swallowing screened by a specially trained healthcare professional</td>
<td rowspan="1" colspan="1">35 (47.2)</td>
<td rowspan="1" colspan="1">0.0–100.0</td>
</tr>
<tr><td rowspan="1" colspan="1"> 5. Protocols and procedures are available for patients to receive brain imaging within 1 h of arrival at the hospital</td>
<td rowspan="1" colspan="1">46 (62.1)</td>
<td rowspan="1" colspan="1">25.0–91.7</td>
</tr>
<tr><td rowspan="1" colspan="1"> 6. Protocols are in place to ensure documented multidisciplinary goals are agreed within 5 days of admission to hospital</td>
<td rowspan="1" colspan="1">31 (41.8)</td>
<td rowspan="1" colspan="1">8.3–66.7</td>
</tr>
<tr><td rowspan="1" colspan="1"> 7. There is immediate access (1 h) to a specialist acute stroke unit (or area) for those with persisting neurological symptoms</td>
<td rowspan="1" colspan="1">51 (68.9)</td>
<td rowspan="1" colspan="1">50.0–83.3</td>
</tr>
<tr><td rowspan="1" colspan="1">Overall score, mean (SD)</td>
<td rowspan="1" colspan="1">3.0 (1.0)</td>
<td rowspan="1" colspan="1"></td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn><p><sup>a</sup>
Minimum–maximum percentage of fully compliant hospitals by country used to determine country ranges.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="MZU016TB4" position="float"><label>Table 4</label>
<caption><p>Compliance with evidence-based organization of care pathway recommendations for obstetric deliveries and hip fracture<sup>a</sup>
</p>
</caption>
<table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col>
<col align="left" span="1"></col>
<col align="char" char="." span="1"></col>
</colgroup>
<thead><tr><th align="left" rowspan="1" colspan="1">Item</th>
<th align="left" rowspan="1" colspan="1"><italic>n</italic>
(%), full compliance</th>
<th align="left" rowspan="1" colspan="1">Average country range (%)</th>
</tr>
</thead>
<tbody><tr><td colspan="3" rowspan="1">Obstetric deliveries (<italic>n</italic>
= 72)</td>
</tr>
<tr><td rowspan="1" colspan="1"> 1.A structured, accurate record of all events during the antenatal childbirth and postnatal periods is maintained for every woman and child</td>
<td rowspan="1" colspan="1">66 (91.6)</td>
<td rowspan="1" colspan="1">58.3–100.0</td>
</tr>
<tr><td rowspan="1" colspan="1"> 2. All women who have epidural analgesia or an operative delivery have their pain assessed using a pain assessment tool approved by the hospital</td>
<td rowspan="1" colspan="1">42 (58.3)</td>
<td rowspan="1" colspan="1">8.3–100.0</td>
</tr>
<tr><td rowspan="1" colspan="1"> 3. There is prompt access to ultrasound facilities with trained staff</td>
<td rowspan="1" colspan="1">72 (100)</td>
<td rowspan="1" colspan="1">100.0–100.0</td>
</tr>
<tr><td rowspan="1" colspan="1"> 4. There is a procedure that guarantees that all women who are identified in the screening program as at risk of rhesus disease are properly managed</td>
<td rowspan="1" colspan="1">44 (61.1)</td>
<td rowspan="1" colspan="1">25.0–100.0</td>
</tr>
<tr><td rowspan="1" colspan="1"> 5. Each woman receives one-to-one midwifery care from a trained midwife during established labor and childbirth</td>
<td rowspan="1" colspan="1">63 (87.5)</td>
<td rowspan="1" colspan="1">0.0–100.0</td>
</tr>
<tr><td rowspan="1" colspan="1"> 6. Epidural analgesia is available at all times</td>
<td rowspan="1" colspan="1">61 (84.7)</td>
<td rowspan="1" colspan="1">58.3–100.0</td>
</tr>
<tr><td rowspan="1" colspan="1"> 7. Adult intensive care facilities and specialist medical back-up are available onsite</td>
<td rowspan="1" colspan="1">70 (97.2)</td>
<td rowspan="1" colspan="1">90.9–100.0</td>
</tr>
<tr><td rowspan="1" colspan="1"> 8. Patient monitoring equipment and clinical expertise in its management are available within the obstetric unit</td>
<td rowspan="1" colspan="1">71 (98.6)</td>
<td rowspan="1" colspan="1">91.7–100.0</td>
</tr>
<tr><td rowspan="1" colspan="1"> 9. There is a system in place to ensure that anesthetic and theater services respond within 30 min to obstetric emergencies and expedite delivery in the event of maternal or fetal compromise</td>
<td rowspan="1" colspan="1">69 (95.8)</td>
<td rowspan="1" colspan="1">83.3–100.0</td>
</tr>
<tr><td rowspan="1" colspan="1"> 10. All babies are clinically examined prior to discharge from hospital and/or within 72 h of birth by a suitably qualified healthcare professional</td>
<td rowspan="1" colspan="1">71 (98.6)</td>
<td rowspan="1" colspan="1">90.9–100.0</td>
</tr>
<tr><td rowspan="1" colspan="1"> Overall score, mean (SD)</td>
<td rowspan="1" colspan="1">3.7 (0.3)</td>
<td rowspan="1" colspan="1"></td>
</tr>
<tr><td colspan="3" rowspan="1">Hip fracture (<italic>n</italic>
= 74)</td>
</tr>
<tr><td rowspan="1" colspan="1"> 1. The guidelines require that medical staff assess patients suspected of having a fractured hip within 1 h of arrival in the emergency department or of the incident if the patient was already in hospital</td>
<td rowspan="1" colspan="1">27 (36.4)</td>
<td rowspan="1" colspan="1">0.0–75.0</td>
</tr>
<tr><td rowspan="1" colspan="1"> 2. The guidelines require a multidisciplinary assessment plan and individual goals for rehabilitation to be documented within 24 h postoperatively</td>
<td rowspan="1" colspan="1">16 (21.6)</td>
<td rowspan="1" colspan="1">0.0–75.0</td>
</tr>
<tr><td rowspan="1" colspan="1"> 3. Magnetic resonance imaging (MRI) is immediately available if hip fracture is suspected, despite negative plain X-rays</td>
<td rowspan="1" colspan="1">40 (54.0)</td>
<td rowspan="1" colspan="1">0.0–100.0</td>
</tr>
<tr><td rowspan="1" colspan="1"> 4. The guidelines require that all patients presenting with a fragility (pathological) fracture are managed on a ward with routine access to orthogeriatric medical support</td>
<td rowspan="1" colspan="1">14 (18.9)</td>
<td rowspan="1" colspan="1">0.0–75.0</td>
</tr>
<tr><td rowspan="1" colspan="1"> 5. Whenever clinically appropriate, surgery is performed within 48 h of admission</td>
<td rowspan="1" colspan="1">45 (60.8)</td>
<td rowspan="1" colspan="1">33.3–100.0</td>
</tr>
<tr><td rowspan="1" colspan="1"> 6. Guidelines require that all patients undergoing hip fracture surgery receive antibiotic prophylaxis</td>
<td rowspan="1" colspan="1">51 (68.9)</td>
<td rowspan="1" colspan="1">0.0–100.0</td>
</tr>
<tr><td rowspan="1" colspan="1"> 7. Guidelines require that, if the patient's overall medical condition allows, mobilization begins within 24 h postoperatively</td>
<td rowspan="1" colspan="1">28 (37.8)</td>
<td rowspan="1" colspan="1">0.0–75.0</td>
</tr>
<tr><td rowspan="1" colspan="1"> Overall score, mean (SD)</td>
<td rowspan="1" colspan="1">2.3 (1.0)</td>
<td rowspan="1" colspan="1"></td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn><p><sup>a</sup>
Minimum–maximum percentage of fully compliant hospitals by country used to determine country range.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</p>
<p>Findings for fast-track admission, timely intervention, access to specialist skills, and diagnostic and treatment facilities were similar for stroke and AMI patients. Screening of swallowing by a specially trained healthcare professional in acute stroke patients was limited (47.2%), with dramatic differences in compliance (0–100%) between countries.</p>
<p>Delivery departments showed the best compliance with EBOP, with prompt access to ultrasound facilities available in all 72 departments. In one country, all 10 criteria analyzed were met in all the hospitals, but in the other countries, fewer than half of the departments complied with recommendations regarding pain assessment, one-to-one midwifery care, and screening for Rhesus disease.</p>
<p>Hip fracture departments showed the lowest overall compliance with EBOP and also the highest between-country variability. Six of the seven criteria assessed were not met in at least one country, but were fully met in others. Where indicated, 61% of departments (country range, 33.3–100%) perform hip surgery within 48 h of admission.</p>
<p>Table <xref ref-type="table" rid="MZU016TB5">5</xref>
shows estimates for the covariance parameters from the linear mixed models described above. In the case of PSS (Model 1 of Table <xref ref-type="table" rid="MZU016TB5">5</xref>
), after adjusting for pathway and hospital-level predictors, country differences in our sample accounted for 0% of the total variance. A larger amount of the total variance (65.9%) was explained by differences between hospitals within countries.
<table-wrap id="MZU016TB5" position="float"><label>Table 5</label>
<caption><p>Country- and hospital-level variances (as percentages of the total variance) of PSS and evidence-based organization of the care pathway (EBOP) scores</p>
</caption>
<table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col>
<col align="char" char=" " span="1"></col>
<col align="char" char=" " span="1"></col>
<col align="left" span="1"></col>
<col align="left" span="1"></col>
</colgroup>
<thead><tr><th align="left" rowspan="2" colspan="1"> </th>
<th align="left" rowspan="1" colspan="1">Between-country variability</th>
<th align="left" rowspan="1" colspan="1">Within-country (between-hospital) variability</th>
<th align="left" rowspan="1" colspan="1">Within-hospital (between-department) variability</th>
<th align="left" rowspan="2" colspan="1">Total variance</th>
</tr>
<tr><th align="left" rowspan="1" colspan="1">Variance (%)</th>
<th align="left" rowspan="1" colspan="1">Variance (%)</th>
<th align="left" rowspan="1" colspan="1">Variance (%)</th>
</tr>
</thead>
<tbody><tr><td rowspan="1" colspan="1"><sup>a</sup>
Model 1. PSS modeled as a function of pathway, hospital-level quality implementation, ownership status, teaching status, and size of hospitals with random intercepts for country and hospital nested within country</td>
<td rowspan="1" colspan="1">0 (0)</td>
<td rowspan="1" colspan="1">0.1827 (65.9)</td>
<td rowspan="1" colspan="1">0.0943 (34.1)</td>
<td rowspan="1" colspan="1">0.2770</td>
</tr>
<tr><td rowspan="1" colspan="1"><sup>b</sup>
Model 2. AMI-EBOP modeled as a function of hospital-level quality implementation, ownership status, teaching status, and size of hospitals with random intercepts for country and hospital nested within country</td>
<td rowspan="1" colspan="1">0.0685 (10.1)</td>
<td rowspan="1" colspan="1">0.6127 (89.9)</td>
<td rowspan="1" colspan="1">N.A.</td>
<td rowspan="1" colspan="1">0.6812</td>
</tr>
<tr><td rowspan="1" colspan="1"><sup>b</sup>
Model 3. STROKE-EBOP modeled as a function of hospital-level quality implementation, ownership status, teaching status, and size of hospitals with random intercepts for country and hospital nested within country</td>
<td rowspan="1" colspan="1">0.3078 (31.8)</td>
<td rowspan="1" colspan="1">0.6603 (68.2)</td>
<td rowspan="1" colspan="1">N.A.</td>
<td rowspan="1" colspan="1">0.9681</td>
</tr>
<tr><td rowspan="1" colspan="1"><sup>b</sup>
Model 4.OBSTETRIC DELIVERIES-EBOP modeled as a function of hospital level quality implementation, ownership status, teaching status, and size of hospitals with random intercepts for country and hospital nested within country</td>
<td rowspan="1" colspan="1">0.0557 (40.0)</td>
<td rowspan="1" colspan="1">0.0835 (60.0)</td>
<td rowspan="1" colspan="1">N.A.</td>
<td rowspan="1" colspan="1">0.1392</td>
</tr>
<tr><td rowspan="1" colspan="1"><sup>b</sup>
Model 5. HIP FRACTURE-EBOP modeled as a function of hospital-level quality implementation, ownership status, teaching status, and size of hospitals with random intercepts for country and hospital nested within country</td>
<td rowspan="1" colspan="1">0.7226 (56.3)</td>
<td rowspan="1" colspan="1">0.5611 (43.7)</td>
<td rowspan="1" colspan="1">N.A.</td>
<td rowspan="1" colspan="1">1.2837</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn><p><sup>a</sup>
Linear mixed regression with random intercept by country and hospital nested within country, and fixed effects for pathway, hospital-level quality implementation (QMSI, QMSCI, CQII), and hospital characteristics (number of beds, hospital ownership, hospital teaching status).</p>
</fn>
<fn><p><sup>b</sup>
Linear mixed regression by pathway with random intercept by country, and fixed effects for hospital-level quality implementation (QMSI, QMSCI, CQII) and hospital characteristics (number of beds, hospital ownership, hospital teaching status).</p>
</fn>
</table-wrap-foot>
</table-wrap>
</p>
<p>Models 2–5 in Table <xref ref-type="table" rid="MZU016TB5">5</xref>
show variance decomposition results for EBOP. For AMI, obstetric deliveries, and stroke, the proportion of variance explained by between-country variation was considerable, but less (10.1% in AMI, 40.0% in obstetric deliveries, and 31.8% in stroke) than that explained by differences within countries. Between-country differences explained a greater proportion of the variance of EBOP in the hip fracture pathway (56.3%) compared with the other pathways.</p>
</sec>
<sec sec-type="discussion" id="s4"><title>Discussion</title>
<p>We assessed the implementation of PSS and EBOP and possible sources of variation in a large sample of European hospitals. Our results indicate that neither PSS nor EBOP recommendations are routinely followed and that there are substantial differences between departments and hospitals. Our findings raise serious concerns regarding the delivery of optimal care and indicate substantial room for improvement. Unfortunately, there is a scarcity of both literature on compliance with PSS and EBOP recommendations in Europe and comparable indicators. The criteria we used in our assessment were based on guidelines from international expert groups and on research findings and empirical evidence, which in many cases, date back several years.</p>
<p>Our results show that compliance with certain key recommendations is far from ideal. Just one in three wards (in some countries, 1 in 10) have removed potassium chloride concentrate solution from their general stocks, even though this practice was recommended by the UK National Patient Safety Agency as early as 2002 [<xref rid="MZU016C29" ref-type="bibr">29</xref>
] and has since been advocated by many other safety agencies. Other areas, in contrast, seem to have improved. In a similar external ward evaluation conducted in 2007 in eight EU countries, the percentage of wristband-identified patients in medical and surgical wards was 22–30% [<xref rid="MZU016C30" ref-type="bibr">30</xref>
]. In our study, 43.0–59.7% of wards have over 90% of patients adequately identified. While our figures indicate an improvement, they are still far below the compliance rates that would be expected for such a basic and crucial safety recommendation [<xref rid="MZU016C31" ref-type="bibr">31</xref>
].</p>
<p>Prompt, timely intervention is a key component of the care pathway in most conditions. In our study, only 56.0% of clinical areas treating AMI patients (country range, 18.2–85.7%) had verifiable arrangements for patients to receive thrombolysis within the recommended timeframe. While some EBOP recommendations have been fully implemented in some departments and hospitals, in others, they are scarcely visible. The variations in the adoption of these recommendations are similar to those reported for the uptake of research evidence [<xref rid="MZU016C32" ref-type="bibr">32</xref>
] and guidelines in clinical practice [<xref rid="MZU016C33" ref-type="bibr">33</xref>
]. With the exception of timely access to specialized diagnostic and treatment facilities, most of the gaps identified in our study could be remedied with minimum investment and simple strategies such as wristband identification, removal of potassium chloride stocks, or the implementation of swallowing screening protocols for stroke patients. Barriers to implementation might include conflicting messages from different sources and a lack of information in local languages. Additionally, poor compliance with PSS and EBOP recommendations might be influenced by the fact that they are not a legal or contractual requirement and also perhaps by the fact that agencies advocating their implementation have overly focused on the passive dissemination of knowledge, and ignored contextual factors that might facilitate or hinder implementation [<xref rid="MZU016C34" ref-type="bibr">34</xref>
].</p>
<p>In the area of patient safety, differences between hospitals within a country accounted for a greater proportion of the total variance (65.9%), while between-country differences accounted for 0% of the total variance after adjusting for hospital-level predictors. Country-level compliance could be similar, because of a possible direct effect on hospitals of patient safety recommendations by international agencies, and low influence by country policies. In the case of EBOP, between-country differences play more important role and explained at least 30% of the total variance for three of four pathways. One possible explanation could be that EBOP is linked to consensus statements issued by specialist groups that are disseminated nationally through scientific meetings, country-wide recommendations, etc. Variations between countries were lower in areas where more level A evidence was available at the time of the study (e.g. AMI).</p>
<p>Our study has some limitations. Our findings cannot be generalized to the EU as a whole. Although random sampling was performed in each country, the conclusions are not generalizable because of our study design, the limited sample sizes and substantial differences in the percentage of refusals from one country to the next. It was not the aim of this study to present findings that could be generalized or compared at the country level, although such information would logically be of interest to policymakers. Rather, given that all EU hospitals potentially deliver services to all European citizens in the context of cross-border care, we decided to explore potential sources of variation in the measures. Here, again, sample size limitation could be important in the findings analysis because it could contribute to unstable variance estimates. It should also be noted that the instruments used to evaluate PSS and EBOP are new and need further testing and refinement before their widespread use can be recommended. We also did not analyze inter-rater reliability, but potential bias from this source was limited by organizing centralized training sessions and using a limited number of auditors per country. Despite the limitations of our study, we performed one of the largest ever European studies and used an identical set of indicators to measure PSS and EBOP across seven countries.</p>
<p>Regarding implications for policy, healthcare providers, purchasers, and insurers should focus not only on bundles of care but also on timing, as prompt delivery of care can optimize both costs and benefits. Delays can be reduced through investment in skills and equipment, adoption of triage and fast-track strategies, and early transfer of patients to specialist centers where indicated. In stroke patients, for instance, early differentiation between ischemic and haemorrhagic causes is critical to early intervention and faster recovery. In our study, the structures required to grant this ‘window of opportunity’ were in place in just 62.1% of departments, and in some countries, this percentage was as low as 25%. Findings from the Stroke Improvement National Audit Programme of the Royal College of Physicians of London show that the percentage of stroke patients receiving a brain scan within 24 h of admission increased from 42% in 2006 to 90% in 2012 [<xref rid="MZU016C35" ref-type="bibr">35</xref>
], demonstrating that changes in hospital practices can clearly benefit patients. Making PSS and EBOP recommendations, department requirements could help to improve the situation in many areas.</p>
<p>The EU directive on cross-border healthcare [<xref rid="MZU016C13" ref-type="bibr">13</xref>
] requires member states of treatment (where cross-border healthcare is provided) to develop quality and safety standards and guidelines but allows member states of affiliation (where patients are insured) to refuse authorization for treatment in another country for a number of reasons, including exposure ‘with reasonable certainty to a patient-safety risk that cannot be regarded as acceptable’. There is no definition of acceptable risk, but evidence of failure to adopt well-evidenced guidelines on systems to protect patients may offer legitimate grounds for denial of authorization. In our study, 224 (83%) of the 292 departments would be considered ‘unsafe’ if removal of potassium chloride concentrate from general ward stocks was considered essential, and in the case of wristband identification, 140 departments (48%) would not pass the test.</p>
<p>The fact that country differences seem to play a minor role in explaining the variations observed in the implementation of PSS has important policy consequences for EU member states because, at least based on our findings, there are no indications that citizens have a better chance of receiving safer care outside their country. In the case for EBOP, country differences account for more than one-third of variation in three conditions, but within-country differences were the main source of variation, except for hip fracture. This has also important consequences when patients seek for care outside of their country. These findings highlight the importance of compiling public data on the extent of implementation of PSS and EBOP to help citizens to choose hospitals not only outside their country of origin but also within their own country.</p>
</sec>
<sec sec-type="conclusions" id="s5"><title>Conclusions</title>
<p>This study shows significant gaps between knowledge and practice of patient safety and evidence-based organization in a sample of European hospitals. Our findings have implications for both policy and individual welfare as they suggest that a substantial proportion of European citizens are at risk of receiving suboptimal care and compliance with PSS and EBOP varied considerably from one hospital to the next in the same country and less between countries. Citizens need to be informed of these variations and to understand the importance of having access to information on hospital and department compliance with PSS and EBOP recommendations both inside and outside their countries. Direct comparisons were not feasible in our study because of the small sample sizes, but future research could focus on comparative analysis and explore in greater depth the causes of variability within regions, states, and even across borders.</p>
</sec>
<sec id="s6"><title>Funding</title>
<p>This study was funded by the <funding-source>European Commission's Seventh Framework Programme</funding-source>
<award-id>FP7/2007–2013</award-id>
under grant agreement <award-id>n° 24188.</award-id>
Funding to pay the Open Access publication charges for this article was provided by European Commission's Seventh Framework Programme FP7/2007–2013 under grant agreement n° 24188.</p>
</sec>
</body>
<back><ack><title>Acknowledgment</title>
<p>Special thanks to Mrs. Anne Murray for her assistance and comments on the last English version.</p>
</ack>
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<app-group><app><title>Appendix</title>
<p>The DUQuE Project Consortium comprises: N. Klazinga, D.S. Kringos, M.J.M.H. Lombarts, and T. Plochg (Academic Medical Centre—AMC, University of Amsterdam, The Netherlands); M.A. Lopez, M.S., R.S., and P. Vallejo (Avedis Donabedian University Institute-Universitat Autónoma de Barcelona FAD, Red de investigación en servicios de salud en enfermedades crónicas REDISSEC, Spain); P.D.B. and S.K. (Central Denmark Region and Center for Healthcare Improvements, Aalborg University, Denmark); P.M. and F. Saillour-Glenisson (Comité de la Coordination de l'Evaluation Clinique et de la Qualité en Aquitaine, France); F.V. (Czech Accreditation Committee, Czech Republic); M. Car, S. Jones, and E. Klaus (Dr Foster Intelligence—DFI, UK); S. Bottaro and P. Garel (European Hospital and Healthcare Federation-HOPE, Belgium); M. Saluvan (Hacettepe University, Turkey); C. Bruneau and A. Depaigne-Loth (Haute Autorité de la Santé-HAS, France); C.D.S. (University of New South Wales, Australia); A. Hammer, O. Ommen, and H. Pfaff (Institute of Medical Sociology, Health Services Research and Rehabilitation Science, University of Cologne-IMVR, Germany); O.G. (London School of Hygiene and Tropical Medicine, UK); D. Botje and C.W. (The Netherlands Institute for Health Services Research—NIVEL, The Netherlands); H.K.-W. and B.K. (Polish Society for Quality Promotion in Health Care-TPJ, Poland); A. Escoval and A. Lívio (Portuguese Association for Hospital Development-APDH, Portugal) and M. Eiras, M. Franca, and I. Leite (Portuguese Society for Quality in Health Care-SPQS, Portugal); F. Almeman, H. Kus, and K. Ozturk (Turkish Society for Quality Improvement in Healthcare-SKID, Turkey); R. Mannion (University of Birmingham, UK); O.A.A., M.D., C.A.T., and A. Wang (University of California, Los Angeles—UCLA, USA); A. Thompson (University of Edinburgh, UK).</p>
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