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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The global establishment of a highly-fluoroquinolone resistant <italic>Salmonella enterica</italic> serotype Kentucky ST198 strain</title><author><name sortKey="Le Hello, Simon" sort="Le Hello, Simon" uniqKey="Le Hello S" first="Simon" last="Le Hello">Simon Le Hello</name><affiliation><nlm:aff id="aff1"><institution>Unité des Bactéries Pathogènes Entériques, Centre National de Référence des Escherichia coli, Shigella et Salmonella, Institut Pasteur</institution><country>Paris, France</country></nlm:aff></affiliation></author><author><name sortKey="Bekhit, Amany" sort="Bekhit, Amany" uniqKey="Bekhit A" first="Amany" last="Bekhit">Amany Bekhit</name><affiliation><nlm:aff id="aff1"><institution>Unité des Bactéries Pathogènes Entériques, Centre National de Référence des Escherichia coli, Shigella et Salmonella, Institut Pasteur</institution><country>Paris, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Biochemistry Department, Faculty of Pharmacy, Minia University</institution><country>Minia, Egypt</country></nlm:aff></affiliation></author><author><name sortKey="Granier, Sophie A" sort="Granier, Sophie A" uniqKey="Granier S" first="Sophie A." last="Granier">Sophie A. Granier</name><affiliation><nlm:aff id="aff3"><institution>Unité Caractérisation et épidémiologie Bactérienne, Laboratoire de Sécurité des Aliments, Université Paris-Est</institution><country>Anses, Maisons-Alfort, France</country></nlm:aff></affiliation></author><author><name sortKey="Barua, Himel" sort="Barua, Himel" uniqKey="Barua H" first="Himel" last="Barua">Himel Barua</name><affiliation><nlm:aff id="aff4"><institution>Department of Microbiology, Faculty of Veterinary Medicine, Chittagong Veterinary and Animal Sciences University</institution><country>Chittagong, Bangladesh</country></nlm:aff></affiliation></author><author><name sortKey="Beutlich, Janine" sort="Beutlich, Janine" uniqKey="Beutlich J" first="Janine" last="Beutlich">Janine Beutlich</name><affiliation><nlm:aff id="aff5"><institution>Unit Antimicrobial Resistance and Resistance Determinants, National Reference Laboratory for Antimicrobial Resistance, Department Biological Safety, Federal Institute for Risk Assessment</institution><country>Berlin, Germany</country></nlm:aff></affiliation></author><author><name sortKey="Zaj C, Magdalena" sort="Zaj C, Magdalena" uniqKey="Zaj C M" first="Magdalena" last="Zaj C">Magdalena Zaj C</name><affiliation><nlm:aff id="aff6"><institution>Department of Microbiology, National Veterinary Research Institute</institution><country>Puławy, Poland</country></nlm:aff></affiliation></author><author><name sortKey="Munch, Sebastian" sort="Munch, Sebastian" uniqKey="Munch S" first="Sebastian" last="Münch">Sebastian Münch</name><affiliation><nlm:aff id="aff7"><institution>National Reference Centre for Salmonellae and other Bacterial Enteric Pathogens, Robert Koch Institute</institution><country>Wernigerode, Germany</country></nlm:aff></affiliation></author><author><name sortKey="Sintchenko, Vitali" sort="Sintchenko, Vitali" uniqKey="Sintchenko V" first="Vitali" last="Sintchenko">Vitali Sintchenko</name><affiliation><nlm:aff id="aff8"><institution>Centre for Infectious Diseases and Microbiology – Public Health, University of Sydney, ICPMR</institution><country>Sydney, NSW, Australia</country></nlm:aff></affiliation></author><author><name sortKey="Bouchrif, Brahim" sort="Bouchrif, Brahim" uniqKey="Bouchrif B" first="Brahim" last="Bouchrif">Brahim Bouchrif</name><affiliation><nlm:aff id="aff9"><institution>Institut Pasteur du Maroc, Sécurité alimentaire et Environnement</institution><country>Casablanca, Maroc</country></nlm:aff></affiliation></author><author><name sortKey="Fashae, Kayode" sort="Fashae, Kayode" uniqKey="Fashae K" first="Kayode" last="Fashae">Kayode Fashae</name><affiliation><nlm:aff id="aff10"><institution>Department of Microbiology, University of Ibadan</institution><country>Ibadan, Nigeria</country></nlm:aff></affiliation></author><author><name sortKey="Pinsard, Jean Louis" sort="Pinsard, Jean Louis" uniqKey="Pinsard J" first="Jean-Louis" last="Pinsard">Jean-Louis Pinsard</name><affiliation><nlm:aff id="aff11"><institution>Bio Chêne Vert, FINALAB</institution><country>Châteaubourg, France</country></nlm:aff></affiliation></author><author><name sortKey="Sontag, Lucile" sort="Sontag, Lucile" uniqKey="Sontag L" first="Lucile" last="Sontag">Lucile Sontag</name><affiliation><nlm:aff id="aff1"><institution>Unité des Bactéries Pathogènes Entériques, Centre National de Référence des Escherichia coli, Shigella et Salmonella, Institut Pasteur</institution><country>Paris, France</country></nlm:aff></affiliation></author><author><name sortKey="Fabre, Laetitia" sort="Fabre, Laetitia" uniqKey="Fabre L" first="Laetitia" last="Fabre">Laetitia Fabre</name><affiliation><nlm:aff id="aff1"><institution>Unité des Bactéries Pathogènes Entériques, Centre National de Référence des Escherichia coli, Shigella et Salmonella, Institut Pasteur</institution><country>Paris, France</country></nlm:aff></affiliation></author><author><name sortKey="Garnier, Martine" sort="Garnier, Martine" uniqKey="Garnier M" first="Martine" last="Garnier">Martine Garnier</name><affiliation><nlm:aff id="aff1"><institution>Unité des Bactéries Pathogènes Entériques, Centre National de Référence des Escherichia coli, Shigella et Salmonella, Institut Pasteur</institution><country>Paris, France</country></nlm:aff></affiliation></author><author><name sortKey="Guibert, Veronique" sort="Guibert, Veronique" uniqKey="Guibert V" first="Véronique" last="Guibert">Véronique Guibert</name><affiliation><nlm:aff id="aff1"><institution>Unité des Bactéries Pathogènes Entériques, Centre National de Référence des Escherichia coli, Shigella et Salmonella, Institut Pasteur</institution><country>Paris, France</country></nlm:aff></affiliation></author><author><name sortKey="Howard, Peter" sort="Howard, Peter" uniqKey="Howard P" first="Peter" last="Howard">Peter Howard</name><affiliation><nlm:aff id="aff9"><institution>Institut Pasteur du Maroc, Sécurité alimentaire et Environnement</institution><country>Casablanca, Maroc</country></nlm:aff></affiliation></author><author><name sortKey="Hendriksen, Rene S" sort="Hendriksen, Rene S" uniqKey="Hendriksen R" first="Rene S." last="Hendriksen">Rene S. Hendriksen</name><affiliation><nlm:aff id="aff12"><institution>WHO Collaborating Center for Antimicrobial Resistance in Foodborne Pathogens and European Union Reference Laboratory for Antimicrobial Resistance, Technical University of Denmark</institution><country>Kgs. Lyngby, Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Christensen, Jens P" sort="Christensen, Jens P" uniqKey="Christensen J" first="Jens P." last="Christensen">Jens P. Christensen</name><affiliation><nlm:aff id="aff13"><institution>Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen</institution><country>Frederiksberg, Copenhagen, Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Biswas, Paritosh K" sort="Biswas, Paritosh K" uniqKey="Biswas P" first="Paritosh K." last="Biswas">Paritosh K. Biswas</name><affiliation><nlm:aff id="aff4"><institution>Department of Microbiology, Faculty of Veterinary Medicine, Chittagong Veterinary and Animal Sciences University</institution><country>Chittagong, Bangladesh</country></nlm:aff></affiliation></author><author><name sortKey="Cloeckaert, Axel" sort="Cloeckaert, Axel" uniqKey="Cloeckaert A" first="Axel" last="Cloeckaert">Axel Cloeckaert</name><affiliation><nlm:aff id="aff14"><institution>Institut national de la recherche agronomique, UMR1282 Infectiologie et Santé publique</institution><country>Nouzilly, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff15"><institution>Université François Rabelais de Tours, UMR1282 Infectiologie et Santé publique</institution><country>Tours, France</country></nlm:aff></affiliation></author><author><name sortKey="Rabsch, Wolfgang" sort="Rabsch, Wolfgang" uniqKey="Rabsch W" first="Wolfgang" last="Rabsch">Wolfgang Rabsch</name><affiliation><nlm:aff id="aff7"><institution>National Reference Centre for Salmonellae and other Bacterial Enteric Pathogens, Robert Koch Institute</institution><country>Wernigerode, Germany</country></nlm:aff></affiliation></author><author><name sortKey="Wasyl, Dariusz" sort="Wasyl, Dariusz" uniqKey="Wasyl D" first="Dariusz" last="Wasyl">Dariusz Wasyl</name><affiliation><nlm:aff id="aff6"><institution>Department of Microbiology, National Veterinary Research Institute</institution><country>Puławy, Poland</country></nlm:aff></affiliation></author><author><name sortKey="Doublet, Benoit" sort="Doublet, Benoit" uniqKey="Doublet B" first="Benoit" last="Doublet">Benoit Doublet</name><affiliation><nlm:aff id="aff14"><institution>Institut national de la recherche agronomique, UMR1282 Infectiologie et Santé publique</institution><country>Nouzilly, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff15"><institution>Université François Rabelais de Tours, UMR1282 Infectiologie et Santé publique</institution><country>Tours, France</country></nlm:aff></affiliation></author><author><name sortKey="Weill, Francois Xavier" sort="Weill, Francois Xavier" uniqKey="Weill F" first="François-Xavier" last="Weill">François-Xavier Weill</name><affiliation><nlm:aff id="aff1"><institution>Unité des Bactéries Pathogènes Entériques, Centre National de Référence des Escherichia coli, Shigella et Salmonella, Institut Pasteur</institution><country>Paris, France</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24385975</idno><idno type="pmc">3866546</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866546</idno><idno type="RBID">PMC:3866546</idno><idno type="doi">10.3389/fmicb.2013.00395</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">002497</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002497</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The global establishment of a highly-fluoroquinolone resistant <italic>Salmonella enterica</italic> serotype Kentucky ST198 strain</title><author><name sortKey="Le Hello, Simon" sort="Le Hello, Simon" uniqKey="Le Hello S" first="Simon" last="Le Hello">Simon Le Hello</name><affiliation><nlm:aff id="aff1"><institution>Unité des Bactéries Pathogènes Entériques, Centre National de Référence des Escherichia coli, Shigella et Salmonella, Institut Pasteur</institution><country>Paris, France</country></nlm:aff></affiliation></author><author><name sortKey="Bekhit, Amany" sort="Bekhit, Amany" uniqKey="Bekhit A" first="Amany" last="Bekhit">Amany Bekhit</name><affiliation><nlm:aff id="aff1"><institution>Unité des Bactéries Pathogènes Entériques, Centre National de Référence des Escherichia coli, Shigella et Salmonella, Institut Pasteur</institution><country>Paris, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Biochemistry Department, Faculty of Pharmacy, Minia University</institution><country>Minia, Egypt</country></nlm:aff></affiliation></author><author><name sortKey="Granier, Sophie A" sort="Granier, Sophie A" uniqKey="Granier S" first="Sophie A." last="Granier">Sophie A. Granier</name><affiliation><nlm:aff id="aff3"><institution>Unité Caractérisation et épidémiologie Bactérienne, Laboratoire de Sécurité des Aliments, Université Paris-Est</institution><country>Anses, Maisons-Alfort, France</country></nlm:aff></affiliation></author><author><name sortKey="Barua, Himel" sort="Barua, Himel" uniqKey="Barua H" first="Himel" last="Barua">Himel Barua</name><affiliation><nlm:aff id="aff4"><institution>Department of Microbiology, Faculty of Veterinary Medicine, Chittagong Veterinary and Animal Sciences University</institution><country>Chittagong, Bangladesh</country></nlm:aff></affiliation></author><author><name sortKey="Beutlich, Janine" sort="Beutlich, Janine" uniqKey="Beutlich J" first="Janine" last="Beutlich">Janine Beutlich</name><affiliation><nlm:aff id="aff5"><institution>Unit Antimicrobial Resistance and Resistance Determinants, National Reference Laboratory for Antimicrobial Resistance, Department Biological Safety, Federal Institute for Risk Assessment</institution><country>Berlin, Germany</country></nlm:aff></affiliation></author><author><name sortKey="Zaj C, Magdalena" sort="Zaj C, Magdalena" uniqKey="Zaj C M" first="Magdalena" last="Zaj C">Magdalena Zaj C</name><affiliation><nlm:aff id="aff6"><institution>Department of Microbiology, National Veterinary Research Institute</institution><country>Puławy, Poland</country></nlm:aff></affiliation></author><author><name sortKey="Munch, Sebastian" sort="Munch, Sebastian" uniqKey="Munch S" first="Sebastian" last="Münch">Sebastian Münch</name><affiliation><nlm:aff id="aff7"><institution>National Reference Centre for Salmonellae and other Bacterial Enteric Pathogens, Robert Koch Institute</institution><country>Wernigerode, Germany</country></nlm:aff></affiliation></author><author><name sortKey="Sintchenko, Vitali" sort="Sintchenko, Vitali" uniqKey="Sintchenko V" first="Vitali" last="Sintchenko">Vitali Sintchenko</name><affiliation><nlm:aff id="aff8"><institution>Centre for Infectious Diseases and Microbiology – Public Health, University of Sydney, ICPMR</institution><country>Sydney, NSW, Australia</country></nlm:aff></affiliation></author><author><name sortKey="Bouchrif, Brahim" sort="Bouchrif, Brahim" uniqKey="Bouchrif B" first="Brahim" last="Bouchrif">Brahim Bouchrif</name><affiliation><nlm:aff id="aff9"><institution>Institut Pasteur du Maroc, Sécurité alimentaire et Environnement</institution><country>Casablanca, Maroc</country></nlm:aff></affiliation></author><author><name sortKey="Fashae, Kayode" sort="Fashae, Kayode" uniqKey="Fashae K" first="Kayode" last="Fashae">Kayode Fashae</name><affiliation><nlm:aff id="aff10"><institution>Department of Microbiology, University of Ibadan</institution><country>Ibadan, Nigeria</country></nlm:aff></affiliation></author><author><name sortKey="Pinsard, Jean Louis" sort="Pinsard, Jean Louis" uniqKey="Pinsard J" first="Jean-Louis" last="Pinsard">Jean-Louis Pinsard</name><affiliation><nlm:aff id="aff11"><institution>Bio Chêne Vert, FINALAB</institution><country>Châteaubourg, France</country></nlm:aff></affiliation></author><author><name sortKey="Sontag, Lucile" sort="Sontag, Lucile" uniqKey="Sontag L" first="Lucile" last="Sontag">Lucile Sontag</name><affiliation><nlm:aff id="aff1"><institution>Unité des Bactéries Pathogènes Entériques, Centre National de Référence des Escherichia coli, Shigella et Salmonella, Institut Pasteur</institution><country>Paris, France</country></nlm:aff></affiliation></author><author><name sortKey="Fabre, Laetitia" sort="Fabre, Laetitia" uniqKey="Fabre L" first="Laetitia" last="Fabre">Laetitia Fabre</name><affiliation><nlm:aff id="aff1"><institution>Unité des Bactéries Pathogènes Entériques, Centre National de Référence des Escherichia coli, Shigella et Salmonella, Institut Pasteur</institution><country>Paris, France</country></nlm:aff></affiliation></author><author><name sortKey="Garnier, Martine" sort="Garnier, Martine" uniqKey="Garnier M" first="Martine" last="Garnier">Martine Garnier</name><affiliation><nlm:aff id="aff1"><institution>Unité des Bactéries Pathogènes Entériques, Centre National de Référence des Escherichia coli, Shigella et Salmonella, Institut Pasteur</institution><country>Paris, France</country></nlm:aff></affiliation></author><author><name sortKey="Guibert, Veronique" sort="Guibert, Veronique" uniqKey="Guibert V" first="Véronique" last="Guibert">Véronique Guibert</name><affiliation><nlm:aff id="aff1"><institution>Unité des Bactéries Pathogènes Entériques, Centre National de Référence des Escherichia coli, Shigella et Salmonella, Institut Pasteur</institution><country>Paris, France</country></nlm:aff></affiliation></author><author><name sortKey="Howard, Peter" sort="Howard, Peter" uniqKey="Howard P" first="Peter" last="Howard">Peter Howard</name><affiliation><nlm:aff id="aff9"><institution>Institut Pasteur du Maroc, Sécurité alimentaire et Environnement</institution><country>Casablanca, Maroc</country></nlm:aff></affiliation></author><author><name sortKey="Hendriksen, Rene S" sort="Hendriksen, Rene S" uniqKey="Hendriksen R" first="Rene S." last="Hendriksen">Rene S. Hendriksen</name><affiliation><nlm:aff id="aff12"><institution>WHO Collaborating Center for Antimicrobial Resistance in Foodborne Pathogens and European Union Reference Laboratory for Antimicrobial Resistance, Technical University of Denmark</institution><country>Kgs. Lyngby, Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Christensen, Jens P" sort="Christensen, Jens P" uniqKey="Christensen J" first="Jens P." last="Christensen">Jens P. Christensen</name><affiliation><nlm:aff id="aff13"><institution>Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen</institution><country>Frederiksberg, Copenhagen, Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Biswas, Paritosh K" sort="Biswas, Paritosh K" uniqKey="Biswas P" first="Paritosh K." last="Biswas">Paritosh K. Biswas</name><affiliation><nlm:aff id="aff4"><institution>Department of Microbiology, Faculty of Veterinary Medicine, Chittagong Veterinary and Animal Sciences University</institution><country>Chittagong, Bangladesh</country></nlm:aff></affiliation></author><author><name sortKey="Cloeckaert, Axel" sort="Cloeckaert, Axel" uniqKey="Cloeckaert A" first="Axel" last="Cloeckaert">Axel Cloeckaert</name><affiliation><nlm:aff id="aff14"><institution>Institut national de la recherche agronomique, UMR1282 Infectiologie et Santé publique</institution><country>Nouzilly, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff15"><institution>Université François Rabelais de Tours, UMR1282 Infectiologie et Santé publique</institution><country>Tours, France</country></nlm:aff></affiliation></author><author><name sortKey="Rabsch, Wolfgang" sort="Rabsch, Wolfgang" uniqKey="Rabsch W" first="Wolfgang" last="Rabsch">Wolfgang Rabsch</name><affiliation><nlm:aff id="aff7"><institution>National Reference Centre for Salmonellae and other Bacterial Enteric Pathogens, Robert Koch Institute</institution><country>Wernigerode, Germany</country></nlm:aff></affiliation></author><author><name sortKey="Wasyl, Dariusz" sort="Wasyl, Dariusz" uniqKey="Wasyl D" first="Dariusz" last="Wasyl">Dariusz Wasyl</name><affiliation><nlm:aff id="aff6"><institution>Department of Microbiology, National Veterinary Research Institute</institution><country>Puławy, Poland</country></nlm:aff></affiliation></author><author><name sortKey="Doublet, Benoit" sort="Doublet, Benoit" uniqKey="Doublet B" first="Benoit" last="Doublet">Benoit Doublet</name><affiliation><nlm:aff id="aff14"><institution>Institut national de la recherche agronomique, UMR1282 Infectiologie et Santé publique</institution><country>Nouzilly, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff15"><institution>Université François Rabelais de Tours, UMR1282 Infectiologie et Santé publique</institution><country>Tours, France</country></nlm:aff></affiliation></author><author><name sortKey="Weill, Francois Xavier" sort="Weill, Francois Xavier" uniqKey="Weill F" first="François-Xavier" last="Weill">François-Xavier Weill</name><affiliation><nlm:aff id="aff1"><institution>Unité des Bactéries Pathogènes Entériques, Centre National de Référence des Escherichia coli, Shigella et Salmonella, Institut Pasteur</institution><country>Paris, France</country></nlm:aff></affiliation></author></analytic><series><title level="j">Frontiers in Microbiology</title><idno type="eISSN">1664-302X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>While the spread of <italic>Salmonella enterica</italic> serotype Kentucky resistant to ciprofloxacin across Africa and the Middle-East has been described recently, the presence of this strain in humans, food, various animal species (livestock, pets, and wildlife) and in environment is suspected in other countries of different continents. Here, we report results of an in-depth molecular epidemiological study on a global human and non-human collection of <italic>S.</italic> Kentucky (<italic>n</italic> = 70). We performed <italic>Xba</italic>I-pulsed field gel electrophoresis and multilocus sequence typing, assessed mutations in the quinolone resistance-determining regions, detected β-lactam resistance mechanisms, and screened the presence of the <italic>Salmonella</italic> genomic island 1 (SGI1). In this study, we highlight the rapid and extensive worldwide dissemination of the ciprofloxacin-resistant <italic>S.</italic> Kentucky ST198-X1-SGI1 strain since the mid-2000s in an increasingly large number of contaminated sources, including the environment. This strain has accumulated an increasing number of chromosomal and plasmid resistance determinants and has been identified in the Indian subcontinent, Southeast Asia and Europe since 2010. The second substitution at position 87 in GyrA (replacing the amino acid Asp) appeared helpful for epidemiological studies to track the origin of contamination. This global study provides evidence leading to the conclusion that high-level resistance to ciprofloxacin in <italic>S.</italic> Kentucky is a simple microbiological trait that facilitates the identification of the epidemic clone of interest, ST198-X1-SGI1. Taking this into account is essential in order to detect and monitor it easily and to take rapid measures in livestock to ensure control of this infection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Achtman, M" uniqKey="Achtman M">M. Achtman</name></author><author><name sortKey="Wain, J" uniqKey="Wain J">J. Wain</name></author><author><name sortKey="Weill, F X" uniqKey="Weill F">F.-X. Weill</name></author><author><name sortKey="Nair, S" uniqKey="Nair S">S. Nair</name></author><author><name sortKey="Zhou, Z" uniqKey="Zhou Z">Z. Zhou</name></author><author><name sortKey="Sangal, V" uniqKey="Sangal V">V. Sangal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Angulo, F J" uniqKey="Angulo F">F. J. Angulo</name></author><author><name sortKey="Johnson, K R" uniqKey="Johnson K">K. R. Johnson</name></author><author><name sortKey="Tauxe, R V" uniqKey="Tauxe R">R. V. Tauxe</name></author><author><name sortKey="Cohen, M L" uniqKey="Cohen M">M. L. Cohen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arlet, G" uniqKey="Arlet G">G. Arlet</name></author><author><name sortKey="Barrett, T J" uniqKey="Barrett T">T. J. Barrett</name></author><author><name sortKey="Butaye, P" uniqKey="Butaye P">P. Butaye</name></author><author><name sortKey="Cloeckaert, A" uniqKey="Cloeckaert A">A. Cloeckaert</name></author><author><name sortKey="Mulvey, M R" uniqKey="Mulvey M">M. R. Mulvey</name></author><author><name sortKey="White, D G" uniqKey="White D">D. G. White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barua, H" uniqKey="Barua H">H. Barua</name></author><author><name sortKey="Biswas, P K" uniqKey="Biswas P">P. K. Biswas</name></author><author><name sortKey="Olsen, K E P" uniqKey="Olsen K">K. E. P. Olsen</name></author><author><name sortKey="Christensen, J P" uniqKey="Christensen J">J. P. Christensen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barua, H" uniqKey="Barua H">H. Barua</name></author><author><name sortKey="Biswas, P K" uniqKey="Biswas P">P. K. Biswas</name></author><author><name sortKey="Olsen, K E P" uniqKey="Olsen K">K. E. P. Olsen</name></author><author><name sortKey="Shil, S K" uniqKey="Shil S">S. K. Shil</name></author><author><name sortKey="Christensen, J P" uniqKey="Christensen J">J. P. Christensen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baucheron, S" uniqKey="Baucheron S">S. Baucheron</name></author><author><name sortKey="Le Hello, S" uniqKey="Le Hello S">S. Le Hello</name></author><author><name sortKey="Doublet, B" uniqKey="Doublet B">B. Doublet</name></author><author><name sortKey="Giraud, E" uniqKey="Giraud E">E. Giraud</name></author><author><name sortKey="Weill, F X" uniqKey="Weill F">F.-X. Weill</name></author><author><name sortKey="Cloeckaert, A" uniqKey="Cloeckaert A">A. Cloeckaert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beutlich, J" uniqKey="Beutlich J">J. Beutlich</name></author><author><name sortKey="Guerra, B" uniqKey="Guerra B">B. Guerra</name></author><author><name sortKey="Schroeter, A" uniqKey="Schroeter A">A. Schroeter</name></author><author><name sortKey="Arvand, M" uniqKey="Arvand M">M. Arvand</name></author><author><name sortKey="Szabo, I" uniqKey="Szabo I">I. Szabo</name></author><author><name sortKey="Helmuth, R" uniqKey="Helmuth R">R. Helmuth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boumghar Bourtchai, L" uniqKey="Boumghar Bourtchai L">L. Boumghar-Bourtchai</name></author><author><name sortKey="Mariani Kurkdjian, P" uniqKey="Mariani Kurkdjian P">P. Mariani-Kurkdjian</name></author><author><name sortKey="Bingen, E" uniqKey="Bingen E">E. Bingen</name></author><author><name sortKey="Filliol, I" uniqKey="Filliol I">I. Filliol</name></author><author><name sortKey="Dhalluin, A" uniqKey="Dhalluin A">A. Dhalluin</name></author><author><name sortKey="Ifrane, S A" uniqKey="Ifrane S">S. A. Ifrane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boyd, D" uniqKey="Boyd D">D. Boyd</name></author><author><name sortKey="Cloeckaert, A" uniqKey="Cloeckaert A">A. Cloeckaert</name></author><author><name sortKey="Chaslus Dancla, E" uniqKey="Chaslus Dancla E">E. Chaslus-Dancla</name></author><author><name sortKey="Mulvey, M R" uniqKey="Mulvey M">M. R. Mulvey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boyd, D" uniqKey="Boyd D">D. Boyd</name></author><author><name sortKey="Peters, G A" uniqKey="Peters G">G. A. Peters</name></author><author><name sortKey="Cloeckaert, A" uniqKey="Cloeckaert A">A. Cloeckaert</name></author><author><name sortKey="Boumedine, K S" uniqKey="Boumedine K">K. S. Boumedine</name></author><author><name sortKey="Chaslus Dancla, E" uniqKey="Chaslus Dancla E">E. Chaslus-Dancla</name></author><author><name sortKey="Imberechts, H" uniqKey="Imberechts H">H. Imberechts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Collard, J M" uniqKey="Collard J">J. M. Collard</name></author><author><name sortKey="Place, S" uniqKey="Place S">S. Place</name></author><author><name sortKey="Denis, O" uniqKey="Denis O">O. Denis</name></author><author><name sortKey="Rodriguez Villalobos, H" uniqKey="Rodriguez Villalobos H">H. Rodriguez-Villalobos</name></author><author><name sortKey="Vrints, M" uniqKey="Vrints M">M. Vrints</name></author><author><name sortKey="Weill, F X" uniqKey="Weill F">F.-X. Weill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Doublet, B" uniqKey="Doublet B">B. Doublet</name></author><author><name sortKey="Praud, K" uniqKey="Praud K">K. Praud</name></author><author><name sortKey="Bertrand, S" uniqKey="Bertrand S">S. Bertrand</name></author><author><name sortKey="Collard, J M" uniqKey="Collard J">J. M. Collard</name></author><author><name sortKey="Weill, F X" uniqKey="Weill F">F.-X. Weill</name></author><author><name sortKey="Cloeckaert, A" uniqKey="Cloeckaert A">A. Cloeckaert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Edwards, P R" uniqKey="Edwards P">P. R. Edwards</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grimont, P A D" uniqKey="Grimont P">P. A. D. Grimont</name></author><author><name sortKey="Weill, F X" uniqKey="Weill F">F.-X. Weill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guillon, F" uniqKey="Guillon F">F. Guillon</name></author><author><name sortKey="Chasset, P" uniqKey="Chasset P">P. Chasset</name></author><author><name sortKey="Le Hello, S" uniqKey="Le Hello S">S. Le Hello</name></author><author><name sortKey="Granier, S A" uniqKey="Granier S">S. A. Granier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hill, D R" uniqKey="Hill D">D. R. Hill</name></author><author><name sortKey="Beeching, N J" uniqKey="Beeching N">N. J. Beeching</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Le Hello, S" uniqKey="Le Hello S">S. Le Hello</name></author><author><name sortKey="Harrois, D" uniqKey="Harrois D">D. Harrois</name></author><author><name sortKey="Bouchrif, B" uniqKey="Bouchrif B">B. Bouchrif</name></author><author><name sortKey="Sontag, L" uniqKey="Sontag L">L. Sontag</name></author><author><name sortKey="Elhani, D" uniqKey="Elhani D">D. Elhani</name></author><author><name sortKey="Guibert, V" uniqKey="Guibert V">V. Guibert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Le Hello, S" uniqKey="Le Hello S">S. Le Hello</name></author><author><name sortKey="Hendriksen, R S" uniqKey="Hendriksen R">R. S. Hendriksen</name></author><author><name sortKey="Doublet, B" uniqKey="Doublet B">B. Doublet</name></author><author><name sortKey="Fisher, I" uniqKey="Fisher I">I. Fisher</name></author><author><name sortKey="Nielsen, E M" uniqKey="Nielsen E">E. M. Nielsen</name></author><author><name sortKey="Whichard, J M" uniqKey="Whichard J">J. M. Whichard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Le Hello, S" uniqKey="Le Hello S">S. Le Hello</name></author><author><name sortKey="Weill, F X" uniqKey="Weill F">F.-X. Weill</name></author><author><name sortKey="Guibert, V" uniqKey="Guibert V">V. Guibert</name></author><author><name sortKey="Praud, K" uniqKey="Praud K">K. Praud</name></author><author><name sortKey="Cloeckaert, A" uniqKey="Cloeckaert A">A. Cloeckaert</name></author><author><name sortKey="Doublet, B" uniqKey="Doublet B">B. Doublet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levings, R S" uniqKey="Levings R">R. S. Levings</name></author><author><name sortKey="Partridge, S R" uniqKey="Partridge S">S. R. Partridge</name></author><author><name sortKey="Djordjevic, S P" uniqKey="Djordjevic S">S. P. Djordjevic</name></author><author><name sortKey="Hall, R M" uniqKey="Hall R">R. M. Hall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, L" uniqKey="Li L">L. Li</name></author><author><name sortKey="Liao, X" uniqKey="Liao X">X. Liao</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name></author><author><name sortKey="Sun, J" uniqKey="Sun J">J. Sun</name></author><author><name sortKey="Li, L" uniqKey="Li L">L. Li</name></author><author><name sortKey="Liu, B" uniqKey="Liu B">B. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mather, A E" uniqKey="Mather A">A. E. Mather</name></author><author><name sortKey="Reid, S W" uniqKey="Reid S">S. W. Reid</name></author><author><name sortKey="Maskell, D J" uniqKey="Maskell D">D. J. Maskell</name></author><author><name sortKey="Parkhill, J" uniqKey="Parkhill J">J. Parkhill</name></author><author><name sortKey="Fookes, M C" uniqKey="Fookes M">M. C. Fookes</name></author><author><name sortKey="Harris, S R" uniqKey="Harris S">S. R. Harris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="M Lbak, K" uniqKey="M Lbak K">K. Mølbak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Munch, S" uniqKey="Munch S">S. Münch</name></author><author><name sortKey="Braun, P" uniqKey="Braun P">P. Braun</name></author><author><name sortKey="Wernery, U" uniqKey="Wernery U">U. Wernery</name></author><author><name sortKey="Kinne, J" uniqKey="Kinne J">J. Kinne</name></author><author><name sortKey="Pees, M" uniqKey="Pees M">M. Pees</name></author><author><name sortKey="Flieger, A" uniqKey="Flieger A">A. Flieger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ribot, E M" uniqKey="Ribot E">E. M. Ribot</name></author><author><name sortKey="Wierzba, R K" uniqKey="Wierzba R">R. K. Wierzba</name></author><author><name sortKey="Angulo, F J" uniqKey="Angulo F">F. J. Angulo</name></author><author><name sortKey="Barrett, T J" uniqKey="Barrett T">T. J. Barrett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tauxe, R V" uniqKey="Tauxe R">R. V. Tauxe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Threlfall, E J" uniqKey="Threlfall E">E. J. Threlfall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turki, Y" uniqKey="Turki Y">Y. Turki</name></author><author><name sortKey="Ouzari, H" uniqKey="Ouzari H">H. Ouzari</name></author><author><name sortKey="Merhi, I" uniqKey="Merhi I">I. Merhi</name></author><author><name sortKey="Ben Aissa, R" uniqKey="Ben Aissa R">R. Ben Aissa</name></author><author><name sortKey="Hassen, A" uniqKey="Hassen A">A. Hassen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walsh, C" uniqKey="Walsh C">C. Walsh</name></author><author><name sortKey="Fanning, S" uniqKey="Fanning S">S. Fanning</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wasyl, D" uniqKey="Wasyl D">D. Wasyl</name></author><author><name sortKey="Hoszowski, A" uniqKey="Hoszowski A">A. Hoszowski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weill, F X" uniqKey="Weill F">F.-X. Weill</name></author><author><name sortKey="Guesnier, F" uniqKey="Guesnier F">F. Guesnier</name></author><author><name sortKey="Guibert, V" uniqKey="Guibert V">V. Guibert</name></author><author><name sortKey="Timinouni, M" uniqKey="Timinouni M">M. Timinouni</name></author><author><name sortKey="Demartin, M" uniqKey="Demartin M">M. Demartin</name></author><author><name sortKey="Polomack, L" uniqKey="Polomack L">L. Polomack</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weill, F X" uniqKey="Weill F">F.-X. Weill</name></author><author><name sortKey="Bertrand, S" uniqKey="Bertrand S">S. Bertrand</name></author><author><name sortKey="Guesnier, F" uniqKey="Guesnier F">F. Guesnier</name></author><author><name sortKey="Baucheron, S" uniqKey="Baucheron S">S. Baucheron</name></author><author><name sortKey="Cloeckaert, A" uniqKey="Cloeckaert A">A. Cloeckaert</name></author><author><name sortKey="Grimont, P A" uniqKey="Grimont P">P. A. Grimont</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weill, F X" uniqKey="Weill F">F.-X. Weill</name></author><author><name sortKey="Fabre, L" uniqKey="Fabre L">L. Fabre</name></author><author><name sortKey="Grandry, B" uniqKey="Grandry B">B. Grandry</name></author><author><name sortKey="Grimont, P A D" uniqKey="Grimont P">P. A. D. Grimont</name></author><author><name sortKey="Casin, I" uniqKey="Casin I">I. Casin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaj C, M" uniqKey="Zaj C M">M. Zając</name></author><author><name sortKey="Wasyl, D" uniqKey="Wasyl D">D. Wasyl</name></author><author><name sortKey="Hoszowski, A" uniqKey="Hoszowski A">A. Hoszowski</name></author><author><name sortKey="Le Hello, S" uniqKey="Le Hello S">S. Le Hello</name></author><author><name sortKey="Szulowski, K" uniqKey="Szulowski K">K. Szulowski</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Microbiol</journal-id><journal-id journal-id-type="iso-abbrev">Front Microbiol</journal-id><journal-id journal-id-type="publisher-id">Front. Microbiol.</journal-id><journal-title-group><journal-title>Frontiers in Microbiology</journal-title></journal-title-group><issn pub-type="epub">1664-302X</issn><publisher><publisher-name>Frontiers Media S.A.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24385975</article-id><article-id pub-id-type="pmc">3866546</article-id><article-id pub-id-type="doi">10.3389/fmicb.2013.00395</article-id><article-categories><subj-group subj-group-type="heading"><subject>Microbiology</subject><subj-group><subject>Original Research Article</subject></subj-group></subj-group></article-categories><title-group><article-title>The global establishment of a highly-fluoroquinolone resistant <italic>Salmonella enterica</italic> serotype Kentucky ST198 strain</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Le Hello</surname><given-names>Simon</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn001"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bekhit</surname><given-names>Amany</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Granier</surname><given-names>Sophie A.</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Barua</surname><given-names>Himel</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Beutlich</surname><given-names>Janine</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zając</surname><given-names>Magdalena</given-names></name><xref ref-type="aff" rid="aff6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Münch</surname><given-names>Sebastian</given-names></name><xref ref-type="aff" rid="aff7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sintchenko</surname><given-names>Vitali</given-names></name><xref ref-type="aff" rid="aff8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bouchrif</surname><given-names>Brahim</given-names></name><xref ref-type="aff" rid="aff9"><sup>9</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fashae</surname><given-names>Kayode</given-names></name><xref ref-type="aff" rid="aff10"><sup>10</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pinsard</surname><given-names>Jean-Louis</given-names></name><xref ref-type="aff" rid="aff11"><sup>11</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sontag</surname><given-names>Lucile</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fabre</surname><given-names>Laetitia</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Garnier</surname><given-names>Martine</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Guibert</surname><given-names>Véronique</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Howard</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="aff9"><sup>9</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hendriksen</surname><given-names>Rene S.</given-names></name><xref ref-type="aff" rid="aff12"><sup>12</sup></xref></contrib><contrib contrib-type="author"><name><surname>Christensen</surname><given-names>Jens P.</given-names></name><xref ref-type="aff" rid="aff13"><sup>13</sup></xref></contrib><contrib contrib-type="author"><name><surname>Biswas</surname><given-names>Paritosh K.</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cloeckaert</surname><given-names>Axel</given-names></name><xref ref-type="aff" rid="aff14"><sup>14</sup></xref><xref ref-type="aff" rid="aff15"><sup>15</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rabsch</surname><given-names>Wolfgang</given-names></name><xref ref-type="aff" rid="aff7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wasyl</surname><given-names>Dariusz</given-names></name><xref ref-type="aff" rid="aff6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Doublet</surname><given-names>Benoit</given-names></name><xref ref-type="aff" rid="aff14"><sup>14</sup></xref><xref ref-type="aff" rid="aff15"><sup>15</sup></xref></contrib><contrib contrib-type="author"><name><surname>Weill</surname><given-names>François-Xavier</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib></contrib-group><aff id="aff1"><sup>1</sup><institution>Unité des Bactéries Pathogènes Entériques, Centre National de Référence des Escherichia coli, Shigella et Salmonella, Institut Pasteur</institution><country>Paris, France</country></aff><aff id="aff2"><sup>2</sup><institution>Biochemistry Department, Faculty of Pharmacy, Minia University</institution><country>Minia, Egypt</country></aff><aff id="aff3"><sup>3</sup><institution>Unité Caractérisation et épidémiologie Bactérienne, Laboratoire de Sécurité des Aliments, Université Paris-Est</institution><country>Anses, Maisons-Alfort, France</country></aff><aff id="aff4"><sup>4</sup><institution>Department of Microbiology, Faculty of Veterinary Medicine, Chittagong Veterinary and Animal Sciences University</institution><country>Chittagong, Bangladesh</country></aff><aff id="aff5"><sup>5</sup><institution>Unit Antimicrobial Resistance and Resistance Determinants, National Reference Laboratory for Antimicrobial Resistance, Department Biological Safety, Federal Institute for Risk Assessment</institution><country>Berlin, Germany</country></aff><aff id="aff6"><sup>6</sup><institution>Department of Microbiology, National Veterinary Research Institute</institution><country>Puławy, Poland</country></aff><aff id="aff7"><sup>7</sup><institution>National Reference Centre for Salmonellae and other Bacterial Enteric Pathogens, Robert Koch Institute</institution><country>Wernigerode, Germany</country></aff><aff id="aff8"><sup>8</sup><institution>Centre for Infectious Diseases and Microbiology – Public Health, University of Sydney, ICPMR</institution><country>Sydney, NSW, Australia</country></aff><aff id="aff9"><sup>9</sup><institution>Institut Pasteur du Maroc, Sécurité alimentaire et Environnement</institution><country>Casablanca, Maroc</country></aff><aff id="aff10"><sup>10</sup><institution>Department of Microbiology, University of Ibadan</institution><country>Ibadan, Nigeria</country></aff><aff id="aff11"><sup>11</sup><institution>Bio Chêne Vert, FINALAB</institution><country>Châteaubourg, France</country></aff><aff id="aff12"><sup>12</sup><institution>WHO Collaborating Center for Antimicrobial Resistance in Foodborne Pathogens and European Union Reference Laboratory for Antimicrobial Resistance, Technical University of Denmark</institution><country>Kgs. Lyngby, Denmark</country></aff><aff id="aff13"><sup>13</sup><institution>Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen</institution><country>Frederiksberg, Copenhagen, Denmark</country></aff><aff id="aff14"><sup>14</sup><institution>Institut national de la recherche agronomique, UMR1282 Infectiologie et Santé publique</institution><country>Nouzilly, France</country></aff><aff id="aff15"><sup>15</sup><institution>Université François Rabelais de Tours, UMR1282 Infectiologie et Santé publique</institution><country>Tours, France</country></aff><author-notes><fn fn-type="edited-by"><p>Edited by: Michel S. Zygmunt, Institut National de la Recherche Agronomique, France</p></fn><fn fn-type="edited-by"><p>Reviewed by: Kunihiko Nishino, Osaka University, Japan; Seamus Fanning, University College Dublin, Ireland</p></fn><corresp id="fn001">*Correspondence: Simon Le Hello, Unité des Bactéries Pathogènes Entériques, Centre National de Référence des Escherichia coli, Shigella et Salmonella, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris cedex 15, France e-mail: <email xlink:type="simple">slehello@pasteur.fr</email></corresp><fn fn-type="other" id="fn002"><p>This article was submitted to Antimicrobials, Resistance and Chemotherapy, a section of the journal Frontiers in Microbiology.</p></fn></author-notes><pub-date pub-type="epub"><day>18</day><month>12</month><year>2013</year></pub-date><pub-date pub-type="collection"><year>2013</year></pub-date><volume>4</volume><elocation-id>395</elocation-id><history><date date-type="received"><day>15</day><month>10</month><year>2013</year></date><date date-type="accepted"><day>03</day><month>12</month><year>2013</year></date></history><permissions><copyright-statement>Copyright © 2013 Le Hello, Bekhit, Granier, Barua, Beutlich, Zając, Münch, Sintchenko, Bouchrif, Fashae, Pinsard, Sontag, Fabre, Garnier, Guibert, Howard, Hendriksen, Christensen, Biswas, Cloeckaert, Rabsch, Wasyl, Doublet and Weill.</copyright-statement><copyright-year>2013</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/3.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p></license></permissions><abstract><p>While the spread of <italic>Salmonella enterica</italic> serotype Kentucky resistant to ciprofloxacin across Africa and the Middle-East has been described recently, the presence of this strain in humans, food, various animal species (livestock, pets, and wildlife) and in environment is suspected in other countries of different continents. Here, we report results of an in-depth molecular epidemiological study on a global human and non-human collection of <italic>S.</italic> Kentucky (<italic>n</italic> = 70). We performed <italic>Xba</italic>I-pulsed field gel electrophoresis and multilocus sequence typing, assessed mutations in the quinolone resistance-determining regions, detected β-lactam resistance mechanisms, and screened the presence of the <italic>Salmonella</italic> genomic island 1 (SGI1). In this study, we highlight the rapid and extensive worldwide dissemination of the ciprofloxacin-resistant <italic>S.</italic> Kentucky ST198-X1-SGI1 strain since the mid-2000s in an increasingly large number of contaminated sources, including the environment. This strain has accumulated an increasing number of chromosomal and plasmid resistance determinants and has been identified in the Indian subcontinent, Southeast Asia and Europe since 2010. The second substitution at position 87 in GyrA (replacing the amino acid Asp) appeared helpful for epidemiological studies to track the origin of contamination. This global study provides evidence leading to the conclusion that high-level resistance to ciprofloxacin in <italic>S.</italic> Kentucky is a simple microbiological trait that facilitates the identification of the epidemic clone of interest, ST198-X1-SGI1. Taking this into account is essential in order to detect and monitor it easily and to take rapid measures in livestock to ensure control of this infection.</p></abstract><kwd-group><kwd><italic>S.</italic> Kentucky</kwd><kwd>ST198</kwd><kwd>SGI1</kwd><kwd>QRDR</kwd><kwd>MDR <italic>Salmonella</italic> dissemination</kwd><kwd>poultry</kwd></kwd-group><counts><fig-count count="2"></fig-count><table-count count="2"></table-count><equation-count count="0"></equation-count><ref-count count="34"></ref-count><page-count count="10"></page-count><word-count count="6448"></word-count></counts></article-meta></front><body><sec id="s1"><title>Introduction</title><p>Despite the substantial progress made in preventing foodborne diseases, new pathogens have emerged, some of which have spread worldwide decade after decade (Tauxe, <xref ref-type="bibr" rid="B26">1997</xref>). These pathogens include strains of multi-drug resistant (MDR) <italic>Salmonella</italic> (Arlet et al., <xref ref-type="bibr" rid="B3">2006</xref>; Walsh and Fanning, <xref ref-type="bibr" rid="B29">2008</xref>). Their treatment in both animals and humans has become more difficult and the number of reports of foodborne infections and outbreaks of MDR <italic>Salmonella</italic> has increased (Angulo et al., <xref ref-type="bibr" rid="B2">2000</xref>; Mølbak, <xref ref-type="bibr" rid="B23">2005</xref>). The global spread of an MDR <italic>Salmonella enterica</italic> serotype Typhimurium phage type DT104 in animals and humans since the 1990s (Threlfall, <xref ref-type="bibr" rid="B27">2000</xref>; Mather et al., <xref ref-type="bibr" rid="B22">2013</xref>) is a good example. While the spread of DT104 may have been facilitated by the use of antimicrobials, the national and international trade of infected animals is thought to have played a major role in its spread across borders (Ribot et al., <xref ref-type="bibr" rid="B25">2002</xref>; Weill et al., <xref ref-type="bibr" rid="B31">2006a</xref>).</p><p>More recently, an emerging <italic>S.</italic> Kentucky strain has been described (Weill et al., <xref ref-type="bibr" rid="B32">2006b</xref>; Le Hello et al., <xref ref-type="bibr" rid="B18">2011</xref>) and belonged to the ST198-X1 subtype. It has accumulated various chromosomal resistance determinants since the mid-1990s with the integration of the <italic>Salmonella</italic> genomic island 1 (SGI1), a 43-kilobase genomic island initially described in DT104 (Boyd et al., <xref ref-type="bibr" rid="B10">2001</xref>), encoding resistance to multiple antimicrobials including amoxicillin, gentamicin, and sulfonamides (Doublet et al., <xref ref-type="bibr" rid="B12">2008</xref>), followed by cumulative mutations in the <italic>gyrA</italic> and <italic>parC</italic> genes, leading to resistance to nalidixic acid and then to ciprofloxacin in 2002 (<italic>S.</italic> Kentucky CIP-R). This population was mostly detected in Egypt before 2005, but has now rapidly spread throughout Africa and the Middle East (Le Hello et al., <xref ref-type="bibr" rid="B18">2011</xref>). Another matter of concern is the expanding livestock reservoir of this <italic>S.</italic> Kentucky CIP-R strain. It was initially identified in autochthonous poultry but was then found in various animals and foods (contaminated spices in France and the United States of America (US), turkey flocks in Germany and Poland, wild animals, etc) (Le Hello et al., <xref ref-type="bibr" rid="B18">2011</xref>; Beutlich et al., <xref ref-type="bibr" rid="B7">2012</xref>; Münch et al., <xref ref-type="bibr" rid="B24">2012</xref>; Wasyl and Hoszowski, <xref ref-type="bibr" rid="B30">2012</xref>). Several isolates give rise to considerable concern, as they have become producers of various carbapenemases and/or cephamycinase and/or extended spectrum β-lactamases (ESBL) (Le Hello et al., <xref ref-type="bibr" rid="B17">2013</xref>).</p><p>Since these studies, several reports have mentioned <italic>S.</italic> Kentucky CIP-R isolates that have been identified from different sources (animals, food, the environment and humans) and geographic locations, in particular in several new countries in the Indian sub-continent and Southeast Asia. The purpose of this study was to examine whether the <italic>S.</italic> Kentucky strains isolated around the world from different ecosystems belong to this expanding ST198-X1-SGI1 strain.</p></sec><sec sec-type="materials|methods" id="s2"><title>Materials and methods</title><sec><title>Collection of strains</title><p>Following the publication of the first studies on <italic>S</italic>. Kentucky ST198-X1-SGI1 CIP-R surveillance (Weill et al., <xref ref-type="bibr" rid="B32">2006b</xref>; Le Hello et al., <xref ref-type="bibr" rid="B18">2011</xref>, <xref ref-type="bibr" rid="B17">2013</xref>), public health agencies in several different regions have notified the same isolation of <italic>S</italic>. Kentucky CIP-R in their animal flocks, in the environment, in food and in humans (traveler-related or domestic). We studied 70 <italic>S</italic>. Kentucky strains from the following participating countries: 41 strains collected from the French National Reference Center for <italic>Salmonella</italic> (FNRC-Salm), 11 from the French Food Safety Agency <italic>Salmonella</italic> network (ANSES Laboratory for Food Safety, Maisons-Alfort, France), six from Denmark (five from the Veterinary Clinical Microbiology Section, Department of Veterinary Disease Biology, University of Copenhagen and one from the Technical University of Denmark, DTU), five from Germany (three from the National Reference Laboratory for <italic>Salmonella</italic>, Federal Institute for Risk Assessment, BfR, and two from the German National Reference Center for Salmonellae and other Enterics, RKI), three from the NSW Enteric Reference Laboratory, ICPMR, Westmead Hospital, Sydney (Australia), two from the National Veterinary Research Institute (Poland) and one from the Institut Pasteur of Morocco, and the reference strain 98K (Edwards, <xref ref-type="bibr" rid="B13">1938</xref>) from the WHO Collaborating Center for Reference and Research on <italic>Salmonella</italic>, Paris, France.</p><p>The global collection, presented in Table <xref ref-type="table" rid="T1">1</xref>, gathers <italic>S</italic>. Kentucky isolates from around the world (four continents, 28 countries) covering a long time-span (including preantibiotic era isolates, from 1937 to 2013), various livestock species (swine, turkey, layer, and broiler poultry farms), humans, food (soya bean, meat, seafood, and spices), wild and domestic animals (reptiles, horses, camels, birds, dogs) and the environment (compost and rivers).</p><table-wrap id="T1" position="float"><label>Table 1</label><caption><p><bold>Characteristics of the <italic>S. enterica</italic> serotype Kentucky isolates that constitute the representative Kentucky ST198 collection in this study</bold>.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1"><bold>Numbering</bold></th><th align="left" rowspan="1" colspan="1"><bold>Year of isolation</bold></th><th align="left" rowspan="1" colspan="1"><bold>Country of contamination</bold></th><th align="left" rowspan="1" colspan="1"><bold>Sources</bold></th><th align="left" rowspan="1" colspan="1"><bold>AST<xref ref-type="table-fn" rid="TN1a"><sup>a</sup></xref></bold></th><th align="left" rowspan="1" colspan="1"><bold><italic>bla</italic> genes<xref ref-type="table-fn" rid="TN1b"><sup>b</sup></xref></bold></th><th align="left" rowspan="1" colspan="1"><bold>Asp87 substitution in GyrA</bold></th><th align="left" rowspan="1" colspan="1"><bold>CIP MIC mg/L</bold></th><th align="left" rowspan="1" colspan="1"><bold>PFGE-type</bold></th><th align="left" rowspan="1" colspan="1"><bold>MLST</bold></th><th align="left" rowspan="1" colspan="1"><bold>SGI1<xref ref-type="table-fn" rid="TN1c"><sup>c</sup></xref></bold></th><th align="left" rowspan="1" colspan="1"><bold>References<xref ref-type="table-fn" rid="TN1d"><sup>d</sup></xref></bold></th></tr></thead><tbody><tr><td align="left" colspan="12" rowspan="1"><bold>HISTORICAL STRAINS (FROM 1937 TO 1999)</bold></td></tr><tr><td align="left" rowspan="1" colspan="1">98K</td><td align="left" rowspan="1" colspan="1">1937</td><td align="left" rowspan="1" colspan="1">USA</td><td align="left" rowspan="1" colspan="1">Chicken</td><td align="left" rowspan="1" colspan="1">Susceptible</td><td align="left" rowspan="1" colspan="1">–</td><td align="left" rowspan="1" colspan="1">No</td><td align="left" rowspan="1" colspan="1">0.008</td><td align="left" rowspan="1" colspan="1">X4</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Absence</td><td align="left" rowspan="1" colspan="1">Edwards, <xref ref-type="bibr" rid="B13">1938</xref></td></tr><tr><td align="left" rowspan="1" colspan="1">1–61</td><td align="left" rowspan="1" colspan="1">1961</td><td align="left" rowspan="1" colspan="1">Senegal</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">Susceptible</td><td align="left" rowspan="1" colspan="1">–</td><td align="left" rowspan="1" colspan="1">No</td><td align="left" rowspan="1" colspan="1">0.016</td><td align="left" rowspan="1" colspan="1">X1d</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Absence</td><td align="left" rowspan="1" colspan="1">Le Hello et al., <xref ref-type="bibr" rid="B18">2011</xref></td></tr><tr><td align="left" rowspan="1" colspan="1">1–66</td><td align="left" rowspan="1" colspan="1">1966</td><td align="left" rowspan="1" colspan="1">Vietnam</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">R2</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">No</td><td align="left" rowspan="1" colspan="1">0.016</td><td align="left" rowspan="1" colspan="1">X18</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Absence</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">1–68</td><td align="left" rowspan="1" colspan="1">1968</td><td align="left" rowspan="1" colspan="1">Senegal</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">SSu</td><td align="left" rowspan="1" colspan="1">–</td><td align="left" rowspan="1" colspan="1">No</td><td align="left" rowspan="1" colspan="1">0.016</td><td align="left" rowspan="1" colspan="1">X1b</td><td align="left" rowspan="1" colspan="1">727</td><td align="left" rowspan="1" colspan="1">Absence</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">2–75</td><td align="left" rowspan="1" colspan="1">1975</td><td align="left" rowspan="1" colspan="1">Senegal</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">Susceptible</td><td align="left" rowspan="1" colspan="1">–</td><td align="left" rowspan="1" colspan="1">No</td><td align="left" rowspan="1" colspan="1">0.023</td><td align="left" rowspan="1" colspan="1">X1b</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Absence</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">5–76</td><td align="left" rowspan="1" colspan="1">1976</td><td align="left" rowspan="1" colspan="1">France</td><td align="left" rowspan="1" colspan="1">Soya bean</td><td align="left" rowspan="1" colspan="1">Susceptible</td><td align="left" rowspan="1" colspan="1">–</td><td align="left" rowspan="1" colspan="1">No</td><td align="left" rowspan="1" colspan="1">0.008</td><td align="left" rowspan="1" colspan="1">X4</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Absence</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">19–85</td><td align="left" rowspan="1" colspan="1">1985</td><td align="left" rowspan="1" colspan="1">Egypt</td><td align="left" rowspan="1" colspan="1">meat</td><td align="left" rowspan="1" colspan="1">SSpSuCTe</td><td align="left" rowspan="1" colspan="1">–</td><td align="left" rowspan="1" colspan="1">No</td><td align="left" rowspan="1" colspan="1">0.016</td><td align="left" rowspan="1" colspan="1">X2b</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">J6</td><td align="left" rowspan="1" colspan="1">Le Hello et al., <xref ref-type="bibr" rid="B18">2011</xref></td></tr><tr><td align="left" rowspan="1" colspan="1">93–6429</td><td align="left" rowspan="1" colspan="1">1993</td><td align="left" rowspan="1" colspan="1">Indonesia</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">Su</td><td align="left" rowspan="1" colspan="1">–</td><td align="left" rowspan="1" colspan="1">No</td><td align="left" rowspan="1" colspan="1">0.016</td><td align="left" rowspan="1" colspan="1">X2c</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">J4</td><td align="left" rowspan="1" colspan="1">Le Hello et al., <xref ref-type="bibr" rid="B19">2012</xref></td></tr><tr><td align="left" rowspan="1" colspan="1">96–11313</td><td align="left" rowspan="1" colspan="1">1996</td><td align="left" rowspan="1" colspan="1">Egypt</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">SSpGSuTe</td><td align="left" rowspan="1" colspan="1">–</td><td align="left" rowspan="1" colspan="1">No</td><td align="left" rowspan="1" colspan="1">0.023</td><td align="left" rowspan="1" colspan="1">X1a</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Ks</td><td align="left" rowspan="1" colspan="1">Le Hello et al., <xref ref-type="bibr" rid="B18">2011</xref></td></tr><tr><td align="left" rowspan="1" colspan="1">97–6819</td><td align="left" rowspan="1" colspan="1">1997</td><td align="left" rowspan="1" colspan="1">Egypt</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">ASSpSuTe</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">No</td><td align="left" rowspan="1" colspan="1">0.008</td><td align="left" rowspan="1" colspan="1">X1a</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Ks</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">97–11473</td><td align="left" rowspan="1" colspan="1">1997</td><td align="left" rowspan="1" colspan="1">Egypt</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">R1-Nal</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">No<xref ref-type="table-fn" rid="TN1e"><sup>1</sup></xref></td><td align="left" rowspan="1" colspan="1">0.125</td><td align="left" rowspan="1" colspan="1">X1k</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Ks</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">99–2998</td><td align="left" rowspan="1" colspan="1">1999</td><td align="left" rowspan="1" colspan="1">Egypt</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">HR1-Nal</td><td align="left" rowspan="1" colspan="1">CMY-2</td><td align="left" rowspan="1" colspan="1">Asn</td><td align="left" rowspan="1" colspan="1">0.125</td><td align="left" rowspan="1" colspan="1">X1t</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Absence</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" colspan="12" rowspan="1"><bold>RECENT STRAINS (SINCE 2000)</bold></td></tr><tr><td align="left" colspan="12" rowspan="1"><bold>HUMAN</bold></td></tr><tr><td align="left" rowspan="1" colspan="1">00–1059</td><td align="left" rowspan="1" colspan="1">2000</td><td align="left" rowspan="1" colspan="1">Egypt</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">R2-Nal</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">No<xref ref-type="table-fn" rid="TN1e"><sup>1</sup></xref></td><td align="left" rowspan="1" colspan="1">0.125</td><td align="left" rowspan="1" colspan="1">X1a</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">P1</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">01–2100</td><td align="left" rowspan="1" colspan="1">2001</td><td align="left" rowspan="1" colspan="1">Egypt</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">R1-Nal</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">No<xref ref-type="table-fn" rid="TN1e"><sup>1</sup></xref></td><td align="left" rowspan="1" colspan="1">0.125</td><td align="left" rowspan="1" colspan="1">X1a</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">K1</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">02–9866</td><td align="left" rowspan="1" colspan="1">2002</td><td align="left" rowspan="1" colspan="1">Egypt</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">R1-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Asn<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">8</td><td align="left" rowspan="1" colspan="1">X1a</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Ks</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">04–4567</td><td align="left" rowspan="1" colspan="1">2004</td><td align="left" rowspan="1" colspan="1">Egypt</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">R1-KTmpCNalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Gly<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">4</td><td align="left" rowspan="1" colspan="1">X1g</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">K1</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">05–1016</td><td align="left" rowspan="1" colspan="1">2005</td><td align="left" rowspan="1" colspan="1">Kenya</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">R3</td><td align="left" rowspan="1" colspan="1">–</td><td align="left" rowspan="1" colspan="1">Tyr<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">4</td><td align="left" rowspan="1" colspan="1">X1a</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Q2</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">05–4680</td><td align="left" rowspan="1" colspan="1">2005</td><td align="left" rowspan="1" colspan="1">Sudan</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">SSpGSuTmpNalCip</td><td align="left" rowspan="1" colspan="1">–</td><td align="left" rowspan="1" colspan="1">Gly<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">4</td><td align="left" rowspan="1" colspan="1">X1l</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">K4</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">07–1511</td><td align="left" rowspan="1" colspan="1">2007</td><td align="left" rowspan="1" colspan="1">Morocco</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">R2-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Asn<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">16</td><td align="left" rowspan="1" colspan="1">X1a</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Ps</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">07–7991</td><td align="left" rowspan="1" colspan="1">2007</td><td align="left" rowspan="1" colspan="1">Tunisia</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">R2-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Asn<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">12</td><td align="left" rowspan="1" colspan="1">X1b</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">08–4705</td><td align="left" rowspan="1" colspan="1">2008</td><td align="left" rowspan="1" colspan="1">Iran</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">R3</td><td align="left" rowspan="1" colspan="1">–</td><td align="left" rowspan="1" colspan="1">Asn<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">12</td><td align="left" rowspan="1" colspan="1">X1a</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">08–5707</td><td align="left" rowspan="1" colspan="1">2008</td><td align="left" rowspan="1" colspan="1">Tanzania</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">R1-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Tyr<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">16</td><td align="left" rowspan="1" colspan="1">X1c</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">09–8391</td><td align="left" rowspan="1" colspan="1">2009</td><td align="left" rowspan="1" colspan="1">Morocco</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">HR2-NalCip</td><td align="left" rowspan="1" colspan="1">CMY-2</td><td align="left" rowspan="1" colspan="1">Asn<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">32</td><td align="left" rowspan="1" colspan="1">X1e</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">Le Hello et al., <xref ref-type="bibr" rid="B17">2013</xref></td></tr><tr><td align="left" rowspan="1" colspan="1">09–9322</td><td align="left" rowspan="1" colspan="1">2009</td><td align="left" rowspan="1" colspan="1">Egypt</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">HR3-NalCipAzi</td><td align="left" rowspan="1" colspan="1">TEM-1 + CMY-2</td><td align="left" rowspan="1" colspan="1">Gly<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">12</td><td align="left" rowspan="1" colspan="1">X1w</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">2010/00305</td><td align="left" rowspan="1" colspan="1">2010</td><td align="left" rowspan="1" colspan="1">Egypt</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">KCTmpNalCip</td><td align="left" rowspan="1" colspan="1">–</td><td align="left" rowspan="1" colspan="1">Gly<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">12</td><td align="left" rowspan="1" colspan="1">X1w</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">2010/00720</td><td align="left" rowspan="1" colspan="1">2010</td><td align="left" rowspan="1" colspan="1">Turkey</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">HR4-NalCip</td><td align="left" rowspan="1" colspan="1">TEM-1 + CTX-M-1</td><td align="left" rowspan="1" colspan="1">Asn<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">16</td><td align="left" rowspan="1" colspan="1">X1b</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">2010/01922</td><td align="left" rowspan="1" colspan="1">2010</td><td align="left" rowspan="1" colspan="1">Morocco</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">HR5-NalCip</td><td align="left" rowspan="1" colspan="1">TEM-1 + VIM-2</td><td align="left" rowspan="1" colspan="1">Gly<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">12</td><td align="left" rowspan="1" colspan="1">X1m</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">2010/05456</td><td align="left" rowspan="1" colspan="1">2010</td><td align="left" rowspan="1" colspan="1">Algeria</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">HR6-NalCipAzi</td><td align="left" rowspan="1" colspan="1">CTX-M-15</td><td align="left" rowspan="1" colspan="1">Asn<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">12</td><td align="left" rowspan="1" colspan="1">X1a</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Qs</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">2010/07071</td><td align="left" rowspan="1" colspan="1">2010</td><td align="left" rowspan="1" colspan="1">Cote d'Ivoire</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">R1-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Tyr<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">12</td><td rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">This study</td></tr><tr><td align="left" rowspan="1" colspan="1">2010/07297</td><td align="left" rowspan="1" colspan="1">2010</td><td align="left" rowspan="1" colspan="1">Unknown</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">ASul</td><td align="left" rowspan="1" colspan="1">PSE-1</td><td align="left" rowspan="1" colspan="1">No</td><td align="left" rowspan="1" colspan="1">0.016</td><td rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">This study</td></tr><tr><td align="left" rowspan="1" colspan="1">2010/07503</td><td align="left" rowspan="1" colspan="1">2010</td><td align="left" rowspan="1" colspan="1">India</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">R1-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Tyr<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">8</td><td align="left" rowspan="1" colspan="1">X1b</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Ks</td><td align="left" rowspan="1" colspan="1">This study</td></tr><tr><td align="left" colspan="12" rowspan="1"><bold>RECENT STRAINS (SINCE 2000) HUMAN</bold></td></tr><tr><td align="left" rowspan="1" colspan="1">2010/08553</td><td align="left" rowspan="1" colspan="1">2010</td><td align="left" rowspan="1" colspan="1">Senegal</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">R1-NalCip</td><td align="left" rowspan="1" colspan="1">TEM-1</td><td align="left" rowspan="1" colspan="1">Asn<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">12</td><td rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">This study</td></tr><tr><td align="left" rowspan="1" colspan="1">2010/09778</td><td align="left" rowspan="1" colspan="1">2010</td><td align="left" rowspan="1" colspan="1">Libya</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">R1-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Asn<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">24</td><td rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">1680</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">This study</td></tr><tr><td align="left" rowspan="1" colspan="1">2011/00664</td><td align="left" rowspan="1" colspan="1">2011</td><td align="left" rowspan="1" colspan="1">Egypt</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">R2-NalCipAzi</td><td align="left" rowspan="1" colspan="1">OXA-48</td><td align="left" rowspan="1" colspan="1">Gly<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">8</td><td align="left" rowspan="1" colspan="1">X1w</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">Le Hello et al., <xref ref-type="bibr" rid="B17">2013</xref></td></tr><tr><td align="left" rowspan="1" colspan="1">2011/01683</td><td align="left" rowspan="1" colspan="1">2011</td><td align="left" rowspan="1" colspan="1">India</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">R1-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Tyr<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">>32</td><td rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">This study</td></tr><tr><td align="left" rowspan="1" colspan="1">2011/01801</td><td align="left" rowspan="1" colspan="1">2011</td><td align="left" rowspan="1" colspan="1">Mali</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">HR2</td><td align="left" rowspan="1" colspan="1">CMY-2</td><td align="left" rowspan="1" colspan="1">No</td><td align="left" rowspan="1" colspan="1">0.016</td><td align="left" rowspan="1" colspan="1">X3</td><td align="left" rowspan="1" colspan="1">1679</td><td align="left" rowspan="1" colspan="1">Absence</td><td align="left" rowspan="1" colspan="1">This study</td></tr><tr><td align="left" rowspan="1" colspan="1">2011/06348</td><td align="left" rowspan="1" colspan="1">2011</td><td align="left" rowspan="1" colspan="1">India</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">R1-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Tyr<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">8</td><td rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">This study</td></tr><tr><td align="left" rowspan="1" colspan="1">201111973</td><td align="left" rowspan="1" colspan="1">2011</td><td align="left" rowspan="1" colspan="1">Cameroon</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">R3</td><td align="left" rowspan="1" colspan="1">-</td><td align="left" rowspan="1" colspan="1">Gly<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">12</td><td rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Qs</td><td align="left" rowspan="1" colspan="1">This study</td></tr><tr><td align="left" rowspan="1" colspan="1">80-11-227-5139</td><td align="left" rowspan="1" colspan="1">2011</td><td align="left" rowspan="1" colspan="1">India</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">R1-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Tyr<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">6</td><td rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">This study</td></tr><tr><td align="left" rowspan="1" colspan="1">80-11-252-4482</td><td align="left" rowspan="1" colspan="1">2011</td><td align="left" rowspan="1" colspan="1">Iraq</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">ASGSulCTeNalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Gly<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">8</td><td rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">This study</td></tr><tr><td align="left" rowspan="1" colspan="1">80-11-309-2385</td><td align="left" rowspan="1" colspan="1">2011</td><td align="left" rowspan="1" colspan="1">Cambodia</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">ASulTeNalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Asn<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">8</td><td rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">This study</td></tr><tr><td align="left" rowspan="1" colspan="1">201203105</td><td align="left" rowspan="1" colspan="1">2012</td><td align="left" rowspan="1" colspan="1">Indonesia</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">R1-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Asn<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">32</td><td align="left" rowspan="1" colspan="1">X1a</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Ks</td><td align="left" rowspan="1" colspan="1">This study</td></tr><tr><td align="left" rowspan="1" colspan="1">201205363</td><td align="left" rowspan="1" colspan="1">2012</td><td align="left" rowspan="1" colspan="1">Kuwait</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">ASSpGTeNalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Gly<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">16</td><td align="left" rowspan="1" colspan="1">X1l</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Ks</td><td align="left" rowspan="1" colspan="1">This study</td></tr><tr><td align="left" rowspan="1" colspan="1">201207374</td><td align="left" rowspan="1" colspan="1">2012</td><td align="left" rowspan="1" colspan="1">Vietnam</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">ASulTeNalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Asn<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">32</td><td align="left" rowspan="1" colspan="1">X1c</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Ks</td><td align="left" rowspan="1" colspan="1">This study</td></tr><tr><td align="left" rowspan="1" colspan="1">2013/01062</td><td align="left" rowspan="1" colspan="1">2013</td><td align="left" rowspan="1" colspan="1">Algeria</td><td align="left" rowspan="1" colspan="1">Human</td><td align="left" rowspan="1" colspan="1">HR7-NalCipAzi</td><td align="left" rowspan="1" colspan="1">TEM-1 + OXA-48</td><td align="left" rowspan="1" colspan="1">Asn<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">8</td><td align="left" rowspan="1" colspan="1">X1b</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Ks</td><td align="left" rowspan="1" colspan="1">This study</td></tr><tr><td align="left" colspan="12" rowspan="1"><bold>NON HUMAN</bold></td></tr><tr><td align="left" rowspan="1" colspan="1">BfR 05-04625</td><td align="left" rowspan="1" colspan="1">2005</td><td align="left" rowspan="1" colspan="1">Ethiopia</td><td align="left" rowspan="1" colspan="1">Swine</td><td align="left" rowspan="1" colspan="1">R3</td><td align="left" rowspan="1" colspan="1">–</td><td align="left" rowspan="1" colspan="1">Gly<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">8</td><td align="left" rowspan="1" colspan="1">X1a</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">This study</td></tr><tr><td align="left" rowspan="1" colspan="1">07AF4403</td><td align="left" rowspan="1" colspan="1">2006</td><td align="left" rowspan="1" colspan="1">Ethiopia</td><td align="left" rowspan="1" colspan="1">Chicken</td><td align="left" rowspan="1" colspan="1">R1-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Gly<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">12</td><td align="left" rowspan="1" colspan="1">X1a</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Ks</td><td align="left" rowspan="1" colspan="1">Le Hello et al., <xref ref-type="bibr" rid="B18">2011</xref></td></tr><tr><td align="left" rowspan="1" colspan="1">Em 06-02339</td><td align="left" rowspan="1" colspan="1">2006</td><td align="left" rowspan="1" colspan="1">United Arab Emirates</td><td align="left" rowspan="1" colspan="1">Camel</td><td align="left" rowspan="1" colspan="1">R1-KNalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Gly<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">8</td><td rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">Münch et al., <xref ref-type="bibr" rid="B24">2012</xref></td></tr><tr><td align="left" rowspan="1" colspan="1">Em 07-04654</td><td align="left" rowspan="1" colspan="1">2007</td><td align="left" rowspan="1" colspan="1">United Arab Emirates</td><td align="left" rowspan="1" colspan="1">Houbara</td><td align="left" rowspan="1" colspan="1">ASSpKTSulTeNalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Gly<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">12</td><td rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">08-KS6</td><td align="left" rowspan="1" colspan="1">2008</td><td align="left" rowspan="1" colspan="1">Nigeria</td><td align="left" rowspan="1" colspan="1">Chicken</td><td align="left" rowspan="1" colspan="1">R1-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Gly<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">12</td><td align="left" rowspan="1" colspan="1">X1a</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Ks</td><td align="left" rowspan="1" colspan="1">Le Hello et al., <xref ref-type="bibr" rid="B18">2011</xref></td></tr><tr><td align="left" rowspan="1" colspan="1">08-015</td><td align="left" rowspan="1" colspan="1">2008</td><td align="left" rowspan="1" colspan="1">Morocco</td><td align="left" rowspan="1" colspan="1">Seafood</td><td align="left" rowspan="1" colspan="1">R1-TNalCip</td><td align="left" rowspan="1" colspan="1">Nd</td><td align="left" rowspan="1" colspan="1">Asn<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">16</td><td align="left" rowspan="1" colspan="1">X1d</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Ks</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">09-8745</td><td align="left" rowspan="1" colspan="1">2009</td><td align="left" rowspan="1" colspan="1">Togo</td><td align="left" rowspan="1" colspan="1">Chicken</td><td align="left" rowspan="1" colspan="1">R1-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Gly<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">12</td><td rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Ks</td><td align="left" rowspan="1" colspan="1">This study</td></tr><tr><td align="left" rowspan="1" colspan="1">K-50</td><td align="left" rowspan="1" colspan="1">2009</td><td align="left" rowspan="1" colspan="1">Bangladesh</td><td align="left" rowspan="1" colspan="1">Layer poultry farms</td><td align="left" rowspan="1" colspan="1">R1-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Tyr<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">8</td><td align="left" rowspan="1" colspan="1">X1e</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">Barua et al., <xref ref-type="bibr" rid="B4">2012</xref></td></tr><tr><td align="left" rowspan="1" colspan="1">K-26</td><td align="left" rowspan="1" colspan="1">2009</td><td align="left" rowspan="1" colspan="1">Bangladesh</td><td align="left" rowspan="1" colspan="1">Layer poultry farms</td><td align="left" rowspan="1" colspan="1">R1-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Tyr<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">16</td><td align="left" rowspan="1" colspan="1">X1e</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Ks</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">BfR 10-02164</td><td align="left" rowspan="1" colspan="1">2010</td><td align="left" rowspan="1" colspan="1">Germany</td><td align="left" rowspan="1" colspan="1">Turkey meat</td><td align="left" rowspan="1" colspan="1">R1-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Tyr<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">8</td><td align="left" rowspan="1" colspan="1">X1b</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Ks</td><td align="left" rowspan="1" colspan="1">Beutlich et al., <xref ref-type="bibr" rid="B7">2012</xref></td></tr><tr><td align="left" rowspan="1" colspan="1">BfR 10-02979</td><td align="left" rowspan="1" colspan="1">2010</td><td align="left" rowspan="1" colspan="1">Germany</td><td align="left" rowspan="1" colspan="1">Reptile organs</td><td align="left" rowspan="1" colspan="1">R1-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Tyr<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">12</td><td align="left" rowspan="1" colspan="1">X1n</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Ks</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">1090/10</td><td align="left" rowspan="1" colspan="1">2010</td><td align="left" rowspan="1" colspan="1">Poland</td><td align="left" rowspan="1" colspan="1">Turkey meat</td><td align="left" rowspan="1" colspan="1">R2-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Tyr<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">16</td><td align="left" rowspan="1" colspan="1">X1b</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">Zając et al., <xref ref-type="bibr" rid="B34">2013</xref></td></tr><tr><td align="left" rowspan="1" colspan="1">10CEB962</td><td align="left" rowspan="1" colspan="1">2010</td><td align="left" rowspan="1" colspan="1">France</td><td align="left" rowspan="1" colspan="1">Compost</td><td align="left" rowspan="1" colspan="1">R2-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Asn<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">12</td><td rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">This study</td></tr><tr><td align="left" rowspan="1" colspan="1">10CEB8465</td><td align="left" rowspan="1" colspan="1">2010</td><td align="left" rowspan="1" colspan="1">Côte d'Ivoire</td><td align="left" rowspan="1" colspan="1">Poultry meat</td><td align="left" rowspan="1" colspan="1">R1-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Tyr<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">8</td><td rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">This study</td></tr><tr><td align="left" rowspan="1" colspan="1">10CEB8748</td><td align="left" rowspan="1" colspan="1">2010</td><td align="left" rowspan="1" colspan="1">France</td><td align="left" rowspan="1" colspan="1">Horse placenta</td><td align="left" rowspan="1" colspan="1">R1-TmpNalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Asn<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">16</td><td rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">This study</td></tr><tr><td align="left" rowspan="1" colspan="1">10CEB8766</td><td align="left" rowspan="1" colspan="1">2010</td><td align="left" rowspan="1" colspan="1">France</td><td align="left" rowspan="1" colspan="1">river</td><td align="left" rowspan="1" colspan="1">SSpGSulTeNalCip</td><td align="left" rowspan="1" colspan="1">–</td><td align="left" rowspan="1" colspan="1">Asn<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">12</td><td rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">This study</td></tr><tr><td align="left" colspan="12" rowspan="1"><bold>NON HUMAN</bold></td></tr><tr><td align="left" rowspan="1" colspan="1">B-81</td><td align="left" rowspan="1" colspan="1">2010</td><td align="left" rowspan="1" colspan="1">Bangladesh</td><td align="left" rowspan="1" colspan="1">Broiler poultry farms</td><td align="left" rowspan="1" colspan="1">R1-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Tyr<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">8</td><td align="left" rowspan="1" colspan="1">X1a</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">Barua et al., <xref ref-type="bibr" rid="B5">2013</xref></td></tr><tr><td align="left" rowspan="1" colspan="1">B-11</td><td align="left" rowspan="1" colspan="1">2010</td><td align="left" rowspan="1" colspan="1">Bangladesh</td><td align="left" rowspan="1" colspan="1">Broiler poultry farms</td><td align="left" rowspan="1" colspan="1">R1-TTmpNalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Tyr<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">8</td><td align="left" rowspan="1" colspan="1">X1e</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">id</td></tr><tr><td align="left" rowspan="1" colspan="1">K-78</td><td align="left" rowspan="1" colspan="1">2010</td><td align="left" rowspan="1" colspan="1">Bangladesh</td><td align="left" rowspan="1" colspan="1">Layer poultry farms</td><td align="left" rowspan="1" colspan="1">R1-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Tyr<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">8</td><td align="left" rowspan="1" colspan="1">X1i</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">Barua et al., <xref ref-type="bibr" rid="B4">2012</xref></td></tr><tr><td align="left" rowspan="1" colspan="1">2189/11</td><td align="left" rowspan="1" colspan="1">2011</td><td align="left" rowspan="1" colspan="1">Poland</td><td align="left" rowspan="1" colspan="1">Reptile</td><td align="left" rowspan="1" colspan="1">R2-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Gly<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">16</td><td align="left" rowspan="1" colspan="1">X1a</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">Zając et al., <xref ref-type="bibr" rid="B34">2013</xref></td></tr><tr><td align="left" rowspan="1" colspan="1">11CEB3342</td><td align="left" rowspan="1" colspan="1">2011</td><td align="left" rowspan="1" colspan="1">France</td><td align="left" rowspan="1" colspan="1">Spice</td><td align="left" rowspan="1" colspan="1">R2-NalCip</td><td align="left" rowspan="1" colspan="1">TEM-1</td><td align="left" rowspan="1" colspan="1">Asn<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">12</td><td rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">This study</td></tr><tr><td align="left" rowspan="1" colspan="1">11CEB4816</td><td align="left" rowspan="1" colspan="1">2011</td><td align="left" rowspan="1" colspan="1">France</td><td align="left" rowspan="1" colspan="1">Marinated turkey meat</td><td align="left" rowspan="1" colspan="1">R1-NalCip</td><td align="left" rowspan="1" colspan="1">TEM-1</td><td align="left" rowspan="1" colspan="1">Tyr<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">12</td><td rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">This study</td></tr><tr><td align="left" rowspan="1" colspan="1">12CEB716</td><td align="left" rowspan="1" colspan="1">2012</td><td align="left" rowspan="1" colspan="1">France</td><td align="left" rowspan="1" colspan="1">Dog</td><td align="left" rowspan="1" colspan="1">R2-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Asn<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">8</td><td rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">+</td><td align="left" rowspan="1" colspan="1">This study</td></tr><tr><td align="left" rowspan="1" colspan="1">12CEB4452</td><td align="left" rowspan="1" colspan="1">2012</td><td align="left" rowspan="1" colspan="1">France</td><td align="left" rowspan="1" colspan="1">Turkey farms</td><td align="left" rowspan="1" colspan="1">R1-NalCip</td><td align="left" rowspan="1" colspan="1">TEM-1</td><td align="left" rowspan="1" colspan="1">Asn<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">16</td><td align="left" rowspan="1" colspan="1">X1f</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Ks</td><td align="left" rowspan="1" colspan="1">Guillon et al., <xref ref-type="bibr" rid="B15">2013</xref></td></tr><tr><td align="left" rowspan="1" colspan="1">13CEB2160</td><td align="left" rowspan="1" colspan="1">2013</td><td align="left" rowspan="1" colspan="1">Poland</td><td align="left" rowspan="1" colspan="1">Turkey meat</td><td align="left" rowspan="1" colspan="1">R1-NalCip</td><td align="left" rowspan="1" colspan="1">TEM</td><td align="left" rowspan="1" colspan="1">Tyr<xref ref-type="table-fn" rid="TN1f"><sup>2</sup></xref></td><td align="left" rowspan="1" colspan="1">8</td><td align="left" rowspan="1" colspan="1">X1x</td><td align="left" rowspan="1" colspan="1">198</td><td align="left" rowspan="1" colspan="1">Ks</td><td align="left" rowspan="1" colspan="1">This study</td></tr></tbody></table><table-wrap-foot><fn id="TN1a"><label>a</label><p>R1: resistance to amoxicillin, A; streptomycin, S; spectinomycin, Sp; gentamicin, G; sulfamethoxazole, Su; and tetracycline, Te.</p></fn><p>R2: resistance to A.</p><p>R3: no resistance associated with NalCip.</p><p>ceftriaxone, Cro; ceftazidime, Caz; cefoxitin, Fox; trimethoprim, Tmp; chloramphenicol, C; azithromycin, Azi; imipenem, Imp; kanamycin, K; tobramycin, T; netilmicin, N; amikacin, A; isepamicin, I.</p><p>HR1: ACroCazFoxSSuTmpCTe.</p><p>HR2: ACroCazFox.</p><p>HR3: ACroCazFoxSSpKTNCSuTmp.</p><p>HR4: ACroSSpGSuTe.</p><p>HR5: ACroCazFoxImpSSpKTNGAISuTe.</p><p>HR6: ACroCazSSpKTGNAISulTmp.</p><p>HR7: AImpSSpGSuTmpTe.</p><fn id="TN1b"><label>b</label><p>Nd, not done; –, any bla gene found.</p></fn><fn id="TN1e"><label>1</label><p>associated with the gyrA Ser83Phe substitution.</p></fn><fn id="TN1f"><label>2</label><p>associated with the gyrA Ser83Phe substitution and parC Ser80Ile substitution.</p></fn><fn id="TN1c"><label>c</label><p>+, positive for SGI1; Js, Ks, Ps, and Qs, variants of SGI1.</p></fn><fn id="TN1d"><label>d</label><p>id, idem, same reference as above.</p></fn></table-wrap-foot></table-wrap></sec><sec><title>Microbiological investigations</title><p>Serotyping was performed on the basis of the White-Kauffmann-Le Minor scheme (Grimont and Weill, <xref ref-type="bibr" rid="B14">2007</xref>). We carried out antimicrobial susceptibility testing (AST) on all <italic>S.</italic> Kentucky isolates with the disk diffusion method, for a panel of 32 antimicrobial drugs (Bio-Rad, Marnes-La-Coquette, France). Using Etests (bioMérieux, Marcy l'′Etoile, France), we determined the minimum inhibitory concentration (MIC) of ciprofloxacin, as previously described (Le Hello et al., <xref ref-type="bibr" rid="B17">2013</xref>). The results were then interpreted using the breakpoints of the Antibiogram Committee of the French Society for Microbiology (CA-SFM) which implements the EUCAST breakpoints. Resistance to ciprofloxacin is defined as having an MIC of more than 1 mg/L and being susceptible at an MIC of 0.5 mg/L or less, irrespective of isolate source (i.e., intestinal or extraintestinal).</p><p>For molecular typing, we performed multilocus sequence typing (MLST) on all <italic>S.</italic> Kentucky isolates and PulseNet standard pulsed-field gel electrophoresis (PFGE) of <italic>Xba</italic>I-digested chromosomal DNA on a selection of isolates (<italic>n</italic> = 50) (Le Hello et al., <xref ref-type="bibr" rid="B18">2011</xref>; Achtman et al., <xref ref-type="bibr" rid="B1">2012</xref>).</p><p>To determine the resistance mechanisms, we assessed the presence of β-lactam resistance genes (<italic>bla</italic><sub><italic>TEM</italic></sub>, <italic>bla</italic><sub><italic>SHV</italic></sub>, <italic>bla</italic><sub><italic>PSE</italic></sub>, <italic>bla</italic><sub><italic>OXA</italic>−1</sub> group, <italic>bla</italic><sub><italic>CMY</italic></sub>, <italic>bla</italic><sub><italic>CTX</italic>−<italic>M</italic></sub>, <italic>bla</italic><sub><italic>OXA</italic>−48</sub>, <italic>bla</italic><sub><italic>VIM</italic></sub>, <italic>bla</italic><sub><italic>NDM</italic></sub>, and <italic>bla</italic><sub><italic>KPC</italic></sub>), plasmid-mediated quinolone resistance genes (known PMQR genes, <italic>qnr</italic>A, <italic>qnr</italic>B, <italic>qnr</italic>S, <italic>qnr</italic>D, <italic>aac(6)′-Ib-cr</italic>, <italic>qep</italic>A and the recent <italic>oqx</italic>A and <italic>oqx</italic>B), macrolide resistance genes (<italic>mph</italic>A) and <italic>Salmonella</italic> genomic island1 (SGI1) by PCR, as described previously (Le Hello et al., <xref ref-type="bibr" rid="B17">2013</xref>; Li et al., <xref ref-type="bibr" rid="B21">2013</xref>). Variants SGI1-K, P, and Q and J were differentiated in some strains (<italic>n</italic> = 28) by selected primers, as described in Table <xref ref-type="table" rid="T2">2</xref> and also described previously (Doublet et al., <xref ref-type="bibr" rid="B12">2008</xref>; Le Hello et al., <xref ref-type="bibr" rid="B19">2012</xref>).</p><table-wrap id="T2" position="float"><label>Table 2</label><caption><p><bold>PCR set (SGI1- Ks, -Ps, and -Qs)</bold>.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1"><bold>PCR No</bold>.</th><th align="left" rowspan="1" colspan="1"><bold>Primer</bold></th><th align="left" rowspan="1" colspan="1"><bold>Nucleotide sequence (5'-3')</bold></th><th align="left" rowspan="1" colspan="1"><bold>Tm(°C)</bold></th><th align="left" rowspan="1" colspan="1"><bold>Size (bp)</bold></th><th align="left" rowspan="1" colspan="1"><bold>Remark</bold></th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">13</td><td align="left" rowspan="1" colspan="1">sulTER</td><td align="left" rowspan="1" colspan="1">AAGGATTTCCTGACCCTG</td><td align="left" rowspan="1" colspan="1">59</td><td align="left" rowspan="1" colspan="1">2040</td><td align="left" rowspan="1" colspan="1">+ for SGI1-Ks</td></tr><tr><td rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">RvTn501</td><td align="left" rowspan="1" colspan="1">ATGGATGTGGTGGCTGAAGG</td><td align="left" rowspan="1" colspan="1">67.2</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">A</td><td align="left" rowspan="1" colspan="1">FwS026</td><td align="left" rowspan="1" colspan="1">CGGTTTTGAATAAGAAGGCA</td><td align="left" rowspan="1" colspan="1">61.5</td><td align="left" rowspan="1" colspan="1">Variable</td><td align="left" rowspan="1" colspan="1">+ for SGI1-Ps</td></tr><tr><td rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">OT4</td><td align="left" rowspan="1" colspan="1">CCAATGCTTAATCAGTGAGG</td><td align="left" rowspan="1" colspan="1">59.7</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">23</td><td align="left" rowspan="1" colspan="1">OT3</td><td align="left" rowspan="1" colspan="1">ATGAGTATTCAACATTTCCG</td><td align="left" rowspan="1" colspan="1">56.5</td><td align="left" rowspan="1" colspan="1">2192</td><td align="left" rowspan="1" colspan="1">+ for SGI1-Ps and – for SGI1-Qs</td></tr><tr><td rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">RvS044c</td><td align="left" rowspan="1" colspan="1">GTATTGTCGTCGGGATGATT</td><td align="left" rowspan="1" colspan="1">61.2</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">C</td><td align="left" rowspan="1" colspan="1">FwS026</td><td align="left" rowspan="1" colspan="1">CGGTTTTGAATAAGAAGGCA</td><td align="left" rowspan="1" colspan="1">61.5</td><td align="left" rowspan="1" colspan="1">Variable (~1500–3000)</td><td align="left" rowspan="1" colspan="1">+ for SGI1-Qs</td></tr><tr><td rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">RvS044c</td><td align="left" rowspan="1" colspan="1">GTATTGTCGTCGGGATGATT</td><td align="left" rowspan="1" colspan="1">61.2</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td></tr></tbody></table></table-wrap><p>The quinolone resistance-determining region (QRDR) of <italic>gyr</italic>A, <italic>gyr</italic>B, <italic>par</italic>C, and <italic>par</italic>E (encoding subunits of the DNA gyrase and the topoisomerase IV) was sequenced in all <italic>S</italic>. Kentucky strains as described previously (Le Hello et al., <xref ref-type="bibr" rid="B17">2013</xref>). The nucleotide and deduced amino acid sequences were analyzed and compared with sequences available from the National Center for Biotechnology Information.</p></sec></sec><sec sec-type="results" id="s3"><title>Results</title><p>The Table <xref ref-type="table" rid="T1">1</xref> presents the characteristics of serotype Kentucky isolates and summarizes the results of antimicrobial resistance and genomic typing.</p><sec><title>Molecular typing</title><p>All but one of the 70 <italic>S</italic>. Kentucky isolates belonged to the e-burst group 56: ST198 and two single locus variants (SLV), ST727 and ST1680. The remaining isolate belonged to a new ST, ST1679, sharing only three loci out of seven (this isolate was susceptible to quinolones and belonged to an X3 PFGE type). We distinguished diverse PFGE types among the ST198 and SLV isolates. The major one, X1 and its many variants (X1a–X1x), representing almost 90% of the ST198 isolates (<italic>n</italic> = 44), has been associated with strains isolated over the last 50 years, whereas X2 (<italic>n</italic> = 2/<italic>N</italic> = 50) has been linked to isolates from Asia isolated before the 2000s and several other patterns for older strains isolated before the 1980s (X4 for the reference strain 98K and strain 5–76 isolated from soya bean, and X18 for a Vietnamese strain, isolated in 1937, 1976, and 1966, respectively). Most common representative PFGE subtypes are shown in Figure <xref ref-type="fig" rid="F1">1</xref>.</p><fig id="F1" position="float"><label>Figure 1</label><caption><p><bold>Representatives of <italic>Xba</italic>I-PFGE profiles obtained among <italic>S. enterica</italic> serotype Kentucky isolates from humans and nonhumans during the period 1937–2013</bold>.</p></caption><graphic xlink:href="fmicb-04-00395-g0001"></graphic></fig><p>The SGI1-K variants were firstly identified in Kentucky ST198 isolates from Egypt in 1996. Then, the SGI1-Ks and its derivative variants -Ps or -Qs were present in all the ST198 (or its SLV) isolates. As shown here, all the SGI1 variants were independently distributed between periods, countries and sources (Table <xref ref-type="table" rid="T1">1</xref>).</p></sec><sec><title>Antimicrobial susceptibility testing and resistance genes</title><p>Among the <italic>S.</italic> Kentucky isolates studied, increased resistance to fluoroquinolones has been observed since the isolation of the first ciprofloxacin-resistant isolate in 2002. As shown in Table <xref ref-type="table" rid="T1">1</xref> ciprofloxacin MICs seem to increase over time, from 0.008 mg/L to 0.125 mg/L during the 1990s, 4 mg/L to 12 mg/L between 2002 and 2006 and since 2007 with the emergence of highly ciprofloxacin resistant strains (16 to >32 mg/L). Apart from quinolone resistance, additional resistance was observed in some <italic>S.</italic> Kentucky CIP-R isolates (Table <xref ref-type="table" rid="T1">1</xref>). The most prevalent drug resistance patterns were R1 (<italic>n</italic> = 25, 46%), which included resistance to amoxicillin, streptomycin, spectinomycin, gentamicin, sulfamethoxazole, and tetracycline; R2 (<italic>n</italic> = 8, 15%), which included resistance to amoxicillin; and R3 (<italic>n</italic> = 4, 7%), which included resistance only to nalidixic acid and ciprofloxacin. Before 2002, these resistance patterns were also described with decreased susceptibility to ciprofloxacin (CIP-DS; MIC, 0.125 mg/L). These patterns and other less frequent ones were all associated with the presence of SGI1-Ks (for R1) and -Ps (for R2), both carrying the <italic>bla</italic><sub><italic>TEM</italic></sub> gene, and -Qs (for R3 which do not carry any drug resistance genes).</p><p>More recently, additional resistance to third generation cephalosporins (C3G) and/or carbapenems was observed in CIP-R <italic>S.</italic> Kentucky X1-ST198-SGI1 isolates. These isolates contained the cephamycinase <italic>bla</italic><sub><italic>CMY</italic>−2</sub> (<italic>n</italic> = 3), the ESBLs <italic>bla</italic><sub><italic>CTX</italic>−<italic>M</italic>−1</sub> (<italic>n</italic> = 1) and <italic>bla</italic><sub><italic>CTX</italic>−<italic>M</italic>−15</sub> (<italic>n</italic> = 1), and the carbapenemases <italic>bla</italic><sub><italic>VIM</italic>−2</sub> (<italic>n</italic> = 1) and <italic>bla</italic><sub><italic>OXA</italic>−48</sub> (<italic>n</italic> = 2). High-level resistance to azithromycin (32 mg/L to 128 mg/L) was found in four of them which carried the phosphotransferase <italic>mph</italic>A gene known to inactivate macrolide antimicrobial drugs.</p><p>In addition to the ST198-X1 SGI1-Ks, -Ps, and -Qs isolates, we observed other drug-resistant <italic>S.</italic> Kentucky ST198 populations in our collection. Initially, we identified ST198-X2, which carried SGI-Js and was isolated in Asia before the 2000s (see Le Hello et al., <xref ref-type="bibr" rid="B19">2012</xref>); secondly, we identified here for the first time a putative SGI1-B variant carrying <italic>S.</italic> Kentucky ST198 isolate (no. 2010/07297) which contains a <italic>bla</italic><sub><italic>PSE</italic>−1</sub> gene found occasionally in other serotypes such as Typhimurium DT104 and Paratyphi B d-tartrate fermenting (Boyd et al., <xref ref-type="bibr" rid="B9">2002</xref>; Weill et al., <xref ref-type="bibr" rid="B33">2005</xref>). Lastly, an SGI1 free isolate susceptible to nalidixic acid and producing the CMY-2 cephamycinase was acquired in Mali in 2011 (no. 2011/01801).</p></sec><sec><title>Temporal and geographic distribution of <italic>s</italic>. kentucky isolates with QRDR mutations</title><p>As shown in Table <xref ref-type="table" rid="T1">1</xref>, ciprofloxacin resistance in all the 54 CIP-R <italic>S</italic>. Kentucky isolates was related to GyrA and ParC substitutions (Table <xref ref-type="table" rid="T1">1</xref>). All contained double substitutions in GyrA (at codons Ser83 and Asp87) and a single ParC substitution (Ser80 encoding an isoleucine residue). None of the isolates contained GyrB or ParE modifications. In GyrA, all the isolates contained phenylalanine at codon Ser83, whereas mutations in codon Asp87 resulted in different substitutions to asparagine (Asn), tyrosine (Tyr), or glycine (Gly) residues depending on the geographic origin of the isolates (Figure <xref ref-type="fig" rid="F2">2</xref>). All the Egyptian isolates presented three possible mutations in codon Asp87 (<italic>n</italic> = 6), whereas the isolates from North Africa (Morocco, Algeria, Tunisia, Libya) had a modification that resulted in Asp87Asn (<italic>n</italic> = 7). An exception was the VIM-2 producing Kentucky 2010/01922 isolate from Morocco which had Asp87Tyr. Those from the Middle East (Iraq, United Arab Emirates, Kuwait, Turkey, and Iran) presented both Asp87Gly and Asp87Asn, apart from two nonhuman Ethiopian isolates and one Sudanese human isolate in 2005 that had an Asp87Gly substitution; those from East Africa, India and Bangladesh had an Asp87Tyr modification (<italic>n</italic> = 12). Apart from the two strains from the Ivory Coast which presented Asp87Tyr, those from West Africa presented Asp87Gly (<italic>n</italic> = 3). All three isolates from Southeast Asia (Cambodia, Indonesia and Vietnam) had an Asp87Asn amino acid change.</p><fig id="F2" position="float"><label>Figure 2</label><caption><p><bold>Geographical distribution in the eastern hemisphere of the different substitutions at codon 87 of GyrA to asparagine (Asn), tyrosine (Tyr), or glycine (Gly) in <italic>S. enterica</italic> serotype Kentucky resistant to ciprofloxacin of the present collection</bold>. H, Human isolates; V, nonhuman isolates.</p></caption><graphic xlink:href="fmicb-04-00395-g0002"></graphic></fig><p>Isolates from food, animal feed and the environment isolated in Europe presented an intermediate situation with isolates mostly having an Asp87Tyr residue in Germany and Poland and an Asp87Asn residue in France.</p><p>No PMQR genes, such as <italic>qnr, aac(6′)-Ib-cr, qepA</italic> and <italic>oqxAB</italic> were detected in <italic>S</italic>. Kentucky CIP-R isolates of this study.</p></sec><sec><title>Nonhuman sources of the <italic>s</italic>. kentucky ST198-x1-SGI1 strain</title><p>The nonhuman isolates of <italic>S</italic>. Kentucky ST198-X1-SGI1 have mainly been found in poultry farms (chicken, layer and turkey, <italic>n</italic> = 14) since its first description in a chicken from Ethiopia in 2006 (Le Hello et al., <xref ref-type="bibr" rid="B18">2011</xref>). This strain has further been described in poultry flocks in East, West and North Africa, the Indian sub-continent and Europe. It has also been described in food products (seafood, meat, or spice), domestic animals (dog, horse, camel, or pet reptiles) and wild animals (houbara or reptiles) and various environments (river or compost) (see Table <xref ref-type="table" rid="T1">1</xref>).</p></sec></sec><sec sec-type="discussion" id="s4"><title>Discussion</title><p>By gathering and studying this global collection, we confirmed that one strain has disseminated throughout the developing countries in both human and nonhuman sources. Strain ST198-X1 displays high-level resistance to ciprofloxacin and harbors SGI1-Ks or its derivative variants -Ps or -Qs. The high-diversity of antibiotic resistance patterns could be related to genetic rearrangements mediated by various insertion sequences (in particular IS26) and transposons in SGI1-Ks, -Ps, and -Qs (Doublet et al., <xref ref-type="bibr" rid="B12">2008</xref>). In parallel, contrary to the relatively few PFGE patterns associated with <italic>S</italic>. Typhimurium DT104, <italic>S</italic>. Kentucky ST198 displayed high-diversity in X1 subtypes, suggesting frequent events of genomic rearrangements present in SGI1 or the acquisition/loss of various plasmids. Several other ST198 strains belonging to other PFGE subtypes and/or containing different antibiotic resistance mechanisms have been isolated sporadically or have no longer been isolated since the 2000s (Le Hello et al., <xref ref-type="bibr" rid="B19">2012</xref>). The odyssey of the <italic>S</italic>. Kentucky ST198-X1 isolate has lasted since it was found in Egypt in the mid-1990s. It has since then accumulated various chromosomal resistance determinants, with the integration of SGI1 (encoding resistance to multiple antimicrobial drugs), followed by cumulative mutations in the <italic>gyr</italic>A and <italic>par</italic>C genes, leading to resistance to nalidixic acid, and then to ciprofloxacin in 2002. Since 2002, this strain has spread rapidly throughout Africa and the Middle East (Le Hello et al., <xref ref-type="bibr" rid="B18">2011</xref>) and, in 2009, it was identified in India in travelers and in Bangladesh in poultry flocks (Barua et al., <xref ref-type="bibr" rid="B4">2012</xref>, <xref ref-type="bibr" rid="B5">2013</xref>). Furthermore, the first description of SGI1 variant K was identified in a <italic>Salmonella</italic> serotype Kentucky strain isolated in 2001 from spices imported into Australia from India (Levings et al., <xref ref-type="bibr" rid="B20">2007</xref>). Since 2011, a pattern of propagation across Asia is also suggested by the recent recovery of ciprofloxacin-resistant <italic>S</italic>. Kentucky isolates from stool samples of patients in France and Australia with a history of recent travel to Vietnam, Cambodia and Indonesia. This global collection also makes it possible to confirm the recent increase of <italic>S</italic>. Kentucky ST198-X1-SGI1 CIP-R clinical strains that have acquired additional genes, making them resistant to extended spectrum cephalosporins and/or carbapenems, in particular in the Mediterranean basin (Collard et al., <xref ref-type="bibr" rid="B11">2007</xref>; Le Hello et al., <xref ref-type="bibr" rid="B17">2013</xref>). High-level resistance to azithromycin due to the acquisition of the <italic>mph</italic>A gene among these isolates is of concern as this antimicrobial agent is presented as a good alternative treatment for severe <italic>Salmonella</italic> infections (Hill and Beeching, <xref ref-type="bibr" rid="B16">2010</xref>) and it completes the variety of enteric bacteria already described producing this phosphotransferase (Boumghar-Bourtchai et al., <xref ref-type="bibr" rid="B8">2008</xref>). Last but not least, as shown in this study, ciprofloxacin MIC has increased decade after decade in <italic>S</italic>. Kentucky isolates. The recent increase in MIC is not due to additional mutations in QRDR, nor to the presence of PMQR. However, the increase could be due to the overexpression of an efflux system such as AcrAB-TolC (Baucheron et al., <xref ref-type="bibr" rid="B6">2013</xref>).</p><p>Another matter of concern is the expanding livestock reservoir of this <italic>S</italic>. Kentucky ST198-X1-SGI1 CIP-R strain, initially identified in African autochthonous poultry but subsequently found in various animals and food (Le Hello et al., <xref ref-type="bibr" rid="B18">2011</xref>; Barua et al., <xref ref-type="bibr" rid="B4">2012</xref>, <xref ref-type="bibr" rid="B5">2013</xref>; Beutlich et al., <xref ref-type="bibr" rid="B7">2012</xref>; Münch et al., <xref ref-type="bibr" rid="B24">2012</xref>; Wasyl and Hoszowski, <xref ref-type="bibr" rid="B30">2012</xref>). Poultry flocks have contributed to the global dissemination of this clone in developing countries since 2005. Hence this strain was isolated in Ethiopia in 2006 (chicken), Nigeria (chicken), and Morocco (turkey) in 2008 (Le Hello et al., <xref ref-type="bibr" rid="B18">2011</xref>), in Togo (chicken) in 2009, and from layers in 2009, from broilers in 2010 in Bangladesh (Barua et al., <xref ref-type="bibr" rid="B4">2012</xref>, <xref ref-type="bibr" rid="B5">2013</xref>), and in developed countries since 2010 (Poland, Wasyl and Hoszowski, <xref ref-type="bibr" rid="B30">2012</xref>; Germany, Beutlich et al., <xref ref-type="bibr" rid="B7">2012</xref>; and France, Guillon et al., <xref ref-type="bibr" rid="B15">2013</xref>). Interestingly, the <italic>S</italic>. Kentucky ST198-X1-SGI1 CIP-R identified in Europe was exclusively associated with turkeys. An investigation following the epidemics in Poland (Wasyl and Hoszowski, <xref ref-type="bibr" rid="B30">2012</xref>) has established that at least one of the infected flocks was hatched from eggs imported from the Middle East. The diversity of nonhuman sources described in this study is another reason of concern. In particular, the description of <italic>S</italic>. Kentucky ST198-X1-SGI1 CIP-R in the environment (rivers and compost) and animals such as reptiles, indicates its potential long-term presence, suggesting its capacity to produce biofilm, as was previously identified in Tunisian isolates (Turki et al., <xref ref-type="bibr" rid="B28">2012</xref>). This intrinsic characteristic could possibly facilitate secondary contaminations and persistence into a novel host/source but this remains to be investigated.</p><p>Regarding its recent establishment in Bangladesh (18% of 500 farms were <italic>S</italic>. Kentucky positive during the period 2009–2010), we do not have any information on how <italic>S</italic>. Kentucky ST198-X1-SGI1 CIP-R was introduced in poultry, although locally produced fish meal used as a protein source has been associated with the presence of <italic>Salmonella</italic> in flocks (Barua et al., <xref ref-type="bibr" rid="B4">2012</xref>, <xref ref-type="bibr" rid="B5">2013</xref>). Small poultry farmers purchase this raw ingredient from the local market to produce low-cost feed by mixing it with other ingredients. Meat and bone meal imported from different countries are also used for preparing poultry and fish feed as a source of protein. Regarding broiler chicks, they are supplied from commercial breeding farms. Further investigations are necessary to obtain information on locally produced poultry feed. The microbiological characteristics of Kentucky ST198-X1-SGI1 CIP-R isolated from poultry farms in Bangladesh indicated that the amino acid substitution in codon 87 of GyrA was exclusively a tyrosine residue like that found in Kentucky for India, East Africa, Egypt and in some Middle East countries. We do not know whether humans play any role in the introduction of this strain in various flocks. Regarding this, it is noteworthy that several million emigrants from Bangladesh work in the Middle East. The human role in the contamination of livestock by <italic>S</italic>. Kentucky ST198-X1-SGI1CIP-R has been pinpointed recently in local turkey flocks in France. The epidemiological investigation performed highlighted the introduction of this strain following the return of farmers from Morocco, a country where this strain is endemic, and suffering from diarrhea (Guillon et al., <xref ref-type="bibr" rid="B15">2013</xref>). This hypothesis may be further reinforced as this isolate (12CEB4452) presented GyrA Asp87Asn substitution which is clearly associated with the North African <italic>S</italic>. Kentucky ST198-X1-SGI1 CIP-R, while isolate 13CEB2160, found in turkey meat sold in France but imported from Poland, presented tyrosine substitution, a characteristic described more frequently in Polish turkey flocks.</p><p>In the era of globalized food supply, livestock, and international human travel, the ciprofloxacin-resistant <italic>S.</italic> Kentucky ST198-X1-SGI1 strain is not restricted to one country, rendering measures to subject livestock to controls more difficult. National and international health, food, and agricultural authorities should include it among the strains targeted in national programs to control <italic>Salmonella</italic> spp in poultry. Based on different studies, including this one, the <italic>S.</italic> Kentucky ST198-X1-SGI1 epidemic clone of interest can nowadays easily be identified by simple serotyping (Kentucky) and by testing its susceptibility <italic>in vitro</italic> to ciprofloxacin (disk diffusion or MIC). It is essential to consider this strain at both national and international level, in order to take preventive measures as soon as possible to limit its worldwide propagation. Like this, we suggest including this emerging <italic>Salmonella</italic> in the European Union's list of target serotypes for mandatory monitoring (EU Commission regulations No.200/2012 of 8 March 2012).</p></sec><sec><title>Author contributions</title><p>Simon Le Hello and François-Xavier Weill conceived and designed the experiments, analyzed the data, and wrote the report. Amany Bekhit, Lucile Sontag, Laetitia Fabre, Martine Garnier, and Véronique Guibert performed the experiments. The other Kentucky working group authors participated in the continuous monitoring of Kentucky strains, sent materials, participated in the discussion and reviewed the manuscript.</p><sec><title>Conflict of interest statement</title><p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p></sec></sec></body><back><ack><p>We would like to thank all the corresponding laboratories of the French National Reference Center for <italic>Escherichia coli</italic>, <italic>Shigella</italic>, and <italic>Salmonella</italic>. The French National Reference Center for <italic>Escherichia coli</italic>, <italic>Shigella</italic>, and <italic>Salmonella</italic> is funded by the Institut Pasteur and the Institut de Veille Sanitaire. The Unité des Bactéries Pathogènes Entériques belongs to the Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence funded by the French Government “Investissement d'Avenir” program (grant number ANR-10-LABX-62-IBEID).</p></ack><ref-list><title>References</title><ref id="B1"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Achtman</surname><given-names>M.</given-names></name><name><surname>Wain</surname><given-names>J.</given-names></name><name><surname>Weill</surname><given-names>F.-X.</given-names></name><name><surname>Nair</surname><given-names>S.</given-names></name><name><surname>Zhou</surname><given-names>Z.</given-names></name><name><surname>Sangal</surname><given-names>V.</given-names></name><etal></etal></person-group> (<year>2012</year>). <article-title>Multilocus sequence typing as a replacement for serotyping in <italic>Salmonella enterica</italic></article-title>. <source>PLoS Pathog</source>. <volume>8</volume>:<fpage>e1002776</fpage><pub-id pub-id-type="doi">10.1371/journal.ppat.1002776</pub-id><pub-id pub-id-type="pmid">22737074</pub-id></mixed-citation></ref><ref id="B2"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Angulo</surname><given-names>F. J.</given-names></name><name><surname>Johnson</surname><given-names>K. R.</given-names></name><name><surname>Tauxe</surname><given-names>R. V.</given-names></name><name><surname>Cohen</surname><given-names>M. L.</given-names></name></person-group> (<year>2000</year>). <article-title>Origins and consequences of antimicrobial-resistant nontyphoidal <italic>Salmonella</italic>: implications for the use of fluoroquinolones in food animals</article-title>. <source>Microb. Drug. Resist</source>. <volume>6</volume>, <fpage>77</fpage>–<lpage>83</lpage><pub-id pub-id-type="doi">10.1089/mdr.2000.6.77</pub-id><pub-id pub-id-type="pmid">10868811</pub-id></mixed-citation></ref><ref id="B3"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Arlet</surname><given-names>G.</given-names></name><name><surname>Barrett</surname><given-names>T. J.</given-names></name><name><surname>Butaye</surname><given-names>P.</given-names></name><name><surname>Cloeckaert</surname><given-names>A.</given-names></name><name><surname>Mulvey</surname><given-names>M. R.</given-names></name><name><surname>White</surname><given-names>D. G.</given-names></name></person-group> (<year>2006</year>). <article-title><italic>Salmonella</italic> resistant to extended-spectrum cephalosporins: prevalence and epidemiology</article-title>. <source>Microbes Infect</source>. <volume>8</volume>, <fpage>1945</fpage>–<lpage>1954</lpage><pub-id pub-id-type="doi">10.1016/j.micinf.2005.12.029</pub-id><pub-id pub-id-type="pmid">16714134</pub-id></mixed-citation></ref><ref id="B4"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Barua</surname><given-names>H.</given-names></name><name><surname>Biswas</surname><given-names>P. K.</given-names></name><name><surname>Olsen</surname><given-names>K. E. P.</given-names></name><name><surname>Christensen</surname><given-names>J. P.</given-names></name></person-group> (<year>2012</year>). <article-title>Prevalence and characterization of motile <italic>Salmonella</italic> in commercial layer poultry farms in Bangladesh</article-title>. <source>PLoS ONE</source><volume>7</volume>:<fpage>e35914</fpage><pub-id pub-id-type="doi">10.1371/journal.pone.0035914</pub-id><pub-id pub-id-type="pmid">22558269</pub-id></mixed-citation></ref><ref id="B5"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Barua</surname><given-names>H.</given-names></name><name><surname>Biswas</surname><given-names>P. K.</given-names></name><name><surname>Olsen</surname><given-names>K. E. P.</given-names></name><name><surname>Shil</surname><given-names>S. K.</given-names></name><name><surname>Christensen</surname><given-names>J. P.</given-names></name></person-group> (<year>2013</year>). <article-title>Molecular characterization of motile serovars of <italic>Salmonella enterica</italic> from breeder and commercial broiler poultry farms in Bangladesh</article-title>. <source>PLoS ONE</source><volume>8</volume>:<fpage>e57811</fpage><pub-id pub-id-type="doi">10.1371/journal.pone.0057811</pub-id><pub-id pub-id-type="pmid">23483931</pub-id></mixed-citation></ref><ref id="B6"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Baucheron</surname><given-names>S.</given-names></name><name><surname>Le Hello</surname><given-names>S.</given-names></name><name><surname>Doublet</surname><given-names>B.</given-names></name><name><surname>Giraud</surname><given-names>E.</given-names></name><name><surname>Weill</surname><given-names>F.-X.</given-names></name><name><surname>Cloeckaert</surname><given-names>A.</given-names></name></person-group> (<year>2013</year>). <article-title><italic>ramR</italic> mutations affecting fluoroquinolone susceptibility in epidemic multidrug-resistant <italic>Salmonella enterica</italic> serovar Kentucky ST198</article-title>. <source>Front. Microbiol</source>. <volume>4</volume>:<issue>213</issue><pub-id pub-id-type="doi">10.3389/fmicb.2013.00213</pub-id><pub-id pub-id-type="pmid">23914184</pub-id></mixed-citation></ref><ref id="B7"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Beutlich</surname><given-names>J.</given-names></name><name><surname>Guerra</surname><given-names>B.</given-names></name><name><surname>Schroeter</surname><given-names>A.</given-names></name><name><surname>Arvand</surname><given-names>M.</given-names></name><name><surname>Szabo</surname><given-names>I.</given-names></name><name><surname>Helmuth</surname><given-names>R.</given-names></name></person-group> (<year>2012</year>). <article-title>[Highly ciprofloxacin resistant <italic>Salmonella enterica</italic> serovar Kentucky isolates in turkey meat and a human patient]</article-title>. <source>Berl. Munch. Tierarztl. Wochenschr</source>. <volume>125</volume>, <fpage>89</fpage>–<lpage>95</lpage><pub-id pub-id-type="doi">10.2376/0005-9366-125-89</pub-id><pub-id pub-id-type="pmid">22515025</pub-id></mixed-citation></ref><ref id="B8"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Boumghar-Bourtchai</surname><given-names>L.</given-names></name><name><surname>Mariani-Kurkdjian</surname><given-names>P.</given-names></name><name><surname>Bingen</surname><given-names>E.</given-names></name><name><surname>Filliol</surname><given-names>I.</given-names></name><name><surname>Dhalluin</surname><given-names>A.</given-names></name><name><surname>Ifrane</surname><given-names>S. A.</given-names></name><etal></etal></person-group> (<year>2008</year>). <article-title>Macrolide-resistant <italic>Shigella sonnei</italic></article-title>. <source>Emerging Infect. Dis</source>. <volume>14</volume>, <fpage>1297</fpage>–<lpage>1299</lpage><pub-id pub-id-type="doi">10.3201/eid1408.080147</pub-id><pub-id pub-id-type="pmid">18680661</pub-id></mixed-citation></ref><ref id="B9"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Boyd</surname><given-names>D.</given-names></name><name><surname>Cloeckaert</surname><given-names>A.</given-names></name><name><surname>Chaslus-Dancla</surname><given-names>E.</given-names></name><name><surname>Mulvey</surname><given-names>M. R.</given-names></name></person-group> (<year>2002</year>). <article-title>Characterization of variant <italic>Salmonella</italic> genomic island 1 multidrug resistance regions from serovars Typhimurium DT104 and Agona</article-title>. <source>Antimicrob. Agents Chemother</source>. <volume>46</volume>, <fpage>1714</fpage>–<lpage>1722</lpage><pub-id pub-id-type="doi">10.1128/AAC.46.6.1714-1722.2002</pub-id><pub-id pub-id-type="pmid">12019080</pub-id></mixed-citation></ref><ref id="B10"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Boyd</surname><given-names>D.</given-names></name><name><surname>Peters</surname><given-names>G. A.</given-names></name><name><surname>Cloeckaert</surname><given-names>A.</given-names></name><name><surname>Boumedine</surname><given-names>K. S.</given-names></name><name><surname>Chaslus-Dancla</surname><given-names>E.</given-names></name><name><surname>Imberechts</surname><given-names>H.</given-names></name><etal></etal></person-group> (<year>2001</year>). <article-title>Complete nucleotide sequence of a 43-kilobase genomic island associated with the multidrug resistance region of <italic>Salmonella enterica</italic> serovar Typhimurium DT104 and its identification in phage type DT120 and serovar Agona</article-title>. <source>J. Bacteriol</source>. <volume>183</volume>, <fpage>5725</fpage>–<lpage>5732</lpage><pub-id pub-id-type="doi">10.1128/JB.183.19.5725-5732.2001</pub-id><pub-id pub-id-type="pmid">11544236</pub-id></mixed-citation></ref><ref id="B11"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Collard</surname><given-names>J. M.</given-names></name><name><surname>Place</surname><given-names>S.</given-names></name><name><surname>Denis</surname><given-names>O.</given-names></name><name><surname>Rodriguez-Villalobos</surname><given-names>H.</given-names></name><name><surname>Vrints</surname><given-names>M.</given-names></name><name><surname>Weill</surname><given-names>F.-X.</given-names></name><etal></etal></person-group> (<year>2007</year>). <article-title>Travel-acquired salmonellosis due to <italic>Salmonella</italic> Kentucky resistant to ciprofloxacin, ceftriaxone and co-trimoxazole and associated with treatment failure</article-title>. <source>J. Antimicrob. Chemother</source>. <volume>60</volume>, <fpage>190</fpage>–<lpage>192</lpage><pub-id pub-id-type="doi">10.1093/jac/dkm114</pub-id><pub-id pub-id-type="pmid">17449886</pub-id></mixed-citation></ref><ref id="B12"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Doublet</surname><given-names>B.</given-names></name><name><surname>Praud</surname><given-names>K.</given-names></name><name><surname>Bertrand</surname><given-names>S.</given-names></name><name><surname>Collard</surname><given-names>J. M.</given-names></name><name><surname>Weill</surname><given-names>F.-X.</given-names></name><name><surname>Cloeckaert</surname><given-names>A.</given-names></name></person-group> (<year>2008</year>). <article-title>Novel insertion sequence- and transposon-mediated genetic rearrangements in genomic island SGI1 of <italic>Salmonella enterica</italic> serovar Kentucky</article-title>. <source>Antimicrob. Agents Chemother</source>. <volume>52</volume>, <fpage>3745</fpage>–<lpage>3754</lpage><pub-id pub-id-type="doi">10.1128/AAC.00525-08</pub-id><pub-id pub-id-type="pmid">18676889</pub-id></mixed-citation></ref><ref id="B13"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Edwards</surname><given-names>P. R.</given-names></name></person-group> (<year>1938</year>). <article-title>A new <italic>Salmonella</italic> type: <italic>Salmonella</italic> Kentucky</article-title>. <source>J. Hyg. (Lond)</source>. <volume>38</volume>, <fpage>306</fpage>–<lpage>308</lpage><pub-id pub-id-type="doi">10.1017/S0022172400011177</pub-id><pub-id pub-id-type="pmid">20475432</pub-id></mixed-citation></ref><ref id="B14"><mixed-citation publication-type="webpage"><person-group person-group-type="author"><name><surname>Grimont</surname><given-names>P. A. D.</given-names></name><name><surname>Weill</surname><given-names>F.-X.</given-names></name></person-group> (<year>2007</year>). <article-title>Antigenic formulae of the <italic>Salmonella</italic> serovars, 9th edn. Paris: WHO Collaborating Center for Reference and Research on <italic>Salmonella</italic>, Institut Pasteur</article-title>. Available online at: <ext-link ext-link-type="uri" xlink:href="http://www.pasteur.fr/cnr/salmonelles">www.pasteur.fr/cnr/salmonelles</ext-link></mixed-citation></ref><ref id="B15"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Guillon</surname><given-names>F.</given-names></name><name><surname>Chasset</surname><given-names>P.</given-names></name><name><surname>Le Hello</surname><given-names>S.</given-names></name><name><surname>Granier</surname><given-names>S. A.</given-names></name></person-group> (<year>2013</year>). <article-title>Epidemiological investigation of highly ciprofloxacin resistant <italic>Salmonella</italic> Kentucky detected for the first time in French avian production</article-title>. <source>Bull. Épidémiol</source>. <volume>57</volume>, <fpage>22</fpage>–<lpage>23</lpage> Available online at: <ext-link ext-link-type="uri" xlink:href="http://www.ansespro.fr/bulletin-epidemiologique/Documents/BEP-mg-BE57.pdf">http://www.ansespro.fr/bulletin-epidemiologique/Documents/BEP-mg-BE57.pdf</ext-link></mixed-citation></ref><ref id="B16"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hill</surname><given-names>D. R.</given-names></name><name><surname>Beeching</surname><given-names>N. J.</given-names></name></person-group> (<year>2010</year>). <article-title>Travelers' diarrhea</article-title>. <source>Curr. Opin. Infect. Dis</source>. <volume>23</volume>, <fpage>481</fpage>–<lpage>487</lpage><pub-id pub-id-type="doi">10.1097/QCO.0b013e32833dfca5</pub-id><pub-id pub-id-type="pmid">20683261</pub-id></mixed-citation></ref><ref id="B17"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Le Hello</surname><given-names>S.</given-names></name><name><surname>Harrois</surname><given-names>D.</given-names></name><name><surname>Bouchrif</surname><given-names>B.</given-names></name><name><surname>Sontag</surname><given-names>L.</given-names></name><name><surname>Elhani</surname><given-names>D.</given-names></name><name><surname>Guibert</surname><given-names>V.</given-names></name><etal></etal></person-group> (<year>2013</year>). <article-title>Highly drug-resistant <italic>Salmonella</italic> Kentucky ST198-X1: a microbiological study</article-title>. <source>Lancet Infect. Dis</source>. <volume>13</volume>, <fpage>672</fpage>–<lpage>679</lpage><pub-id pub-id-type="doi">10.1016/S1473-3099(13)70124-5</pub-id><pub-id pub-id-type="pmid">23721756</pub-id></mixed-citation></ref><ref id="B18"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Le Hello</surname><given-names>S.</given-names></name><name><surname>Hendriksen</surname><given-names>R. S.</given-names></name><name><surname>Doublet</surname><given-names>B.</given-names></name><name><surname>Fisher</surname><given-names>I.</given-names></name><name><surname>Nielsen</surname><given-names>E. M.</given-names></name><name><surname>Whichard</surname><given-names>J. M.</given-names></name><etal></etal></person-group> (<year>2011</year>). <article-title>International spread of an epidemic population of <italic>Salmonella enterica</italic> serotype Kentucky ST198 resistant to ciprofloxacin</article-title>. <source>J. Infect. Dis</source>. <volume>204</volume>, <fpage>675</fpage>–<lpage>684</lpage><pub-id pub-id-type="doi">10.1093/infdis/jir409</pub-id><pub-id pub-id-type="pmid">21813512</pub-id></mixed-citation></ref><ref id="B19"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Le Hello</surname><given-names>S.</given-names></name><name><surname>Weill</surname><given-names>F.-X.</given-names></name><name><surname>Guibert</surname><given-names>V.</given-names></name><name><surname>Praud</surname><given-names>K.</given-names></name><name><surname>Cloeckaert</surname><given-names>A.</given-names></name><name><surname>Doublet</surname><given-names>B.</given-names></name></person-group> (<year>2012</year>). <article-title>Early strains of multidrug-resistant <italic>Salmonella enterica</italic> serovar Kentucky sequence type 198 from Southeast Asia harbor <italic>Salmonella</italic> genomic island 1-J variants with a novel insertion sequence</article-title>. <source>Antimicrob. Agents Chemother</source>. <volume>56</volume>, <fpage>5096</fpage>–<lpage>5102</lpage><pub-id pub-id-type="doi">10.1128/AAC.00732-12</pub-id><pub-id pub-id-type="pmid">22802251</pub-id></mixed-citation></ref><ref id="B20"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Levings</surname><given-names>R. S.</given-names></name><name><surname>Partridge</surname><given-names>S. R.</given-names></name><name><surname>Djordjevic</surname><given-names>S. P.</given-names></name><name><surname>Hall</surname><given-names>R. M.</given-names></name></person-group> (<year>2007</year>). <article-title>SGI1-K, a variant of the SGI1 genomic island carrying a mercury resistance region, in <italic>Salmonella enterica</italic> serovar Kentucky</article-title>. <source>Antimicrob. Agents Chemother</source>. <volume>51</volume>, <fpage>317</fpage>–<lpage>323</lpage><pub-id pub-id-type="doi">10.1128/AAC.01229-06</pub-id><pub-id pub-id-type="pmid">17088481</pub-id></mixed-citation></ref><ref id="B21"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname><given-names>L.</given-names></name><name><surname>Liao</surname><given-names>X.</given-names></name><name><surname>Yang</surname><given-names>Y.</given-names></name><name><surname>Sun</surname><given-names>J.</given-names></name><name><surname>Li</surname><given-names>L.</given-names></name><name><surname>Liu</surname><given-names>B.</given-names></name><etal></etal></person-group> (<year>2013</year>). <article-title>Spread of oqxAB in <italic>Salmonella enterica</italic> serotype Typhimurium predominantly by IncHI2 plasmids</article-title>. <source>J. Antimicrob. Chemother</source>. <volume>68</volume>, <fpage>2263</fpage>–<lpage>2268</lpage><pub-id pub-id-type="doi">10.1093/jac/dkt209</pub-id><pub-id pub-id-type="pmid">23737490</pub-id></mixed-citation></ref><ref id="B22"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mather</surname><given-names>A. E.</given-names></name><name><surname>Reid</surname><given-names>S. W.</given-names></name><name><surname>Maskell</surname><given-names>D. J.</given-names></name><name><surname>Parkhill</surname><given-names>J.</given-names></name><name><surname>Fookes</surname><given-names>M. C.</given-names></name><name><surname>Harris</surname><given-names>S. R.</given-names></name><etal></etal></person-group> (<year>2013</year>). <article-title>Distinguishable epidemics of multidrug-resistant <italic>Salmonella</italic> Typhimurium DT104 in different hosts</article-title>. <source>Science</source><volume>341</volume>, <fpage>1514</fpage>–<lpage>1517</lpage><pub-id pub-id-type="doi">10.1126/science.1240578</pub-id><pub-id pub-id-type="pmid">24030491</pub-id></mixed-citation></ref><ref id="B23"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mølbak</surname><given-names>K.</given-names></name></person-group> (<year>2005</year>). <article-title>Human health consequences of antimicrobial drug-resistant <italic>Salmonella</italic> and other foodborne pathogens</article-title>. <source>Clin. Infect. Dis</source>. <volume>41</volume>, <fpage>1613</fpage>–<lpage>1620</lpage><pub-id pub-id-type="doi">10.1086/497599</pub-id><pub-id pub-id-type="pmid">16267734</pub-id></mixed-citation></ref><ref id="B24"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Münch</surname><given-names>S.</given-names></name><name><surname>Braun</surname><given-names>P.</given-names></name><name><surname>Wernery</surname><given-names>U.</given-names></name><name><surname>Kinne</surname><given-names>J.</given-names></name><name><surname>Pees</surname><given-names>M.</given-names></name><name><surname>Flieger</surname><given-names>A.</given-names></name><etal></etal></person-group> (<year>2012</year>). <article-title>Prevalence, serovars, phage types, and antibiotic susceptibilities of <italic>Salmonella</italic> strains isolated from animals in the United Arab Emirates from 1996 to 2009</article-title>. <source>Trop. Anim. Health Prod</source>. <volume>44</volume>, <fpage>1725</fpage>–<lpage>1738</lpage><pub-id pub-id-type="doi">10.1007/s11250-012-0130-4</pub-id><pub-id pub-id-type="pmid">22476789</pub-id></mixed-citation></ref><ref id="B25"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ribot</surname><given-names>E. M.</given-names></name><name><surname>Wierzba</surname><given-names>R. K.</given-names></name><name><surname>Angulo</surname><given-names>F. J.</given-names></name><name><surname>Barrett</surname><given-names>T. J.</given-names></name></person-group> (<year>2002</year>). <article-title><italic>Salmonella enterica</italic> serotype Typhimurium DT104 isolated from humans, United States, 1985, 1990, and 1995</article-title>. <source>Emerging Infect. Dis</source>. <volume>8</volume>, <fpage>387</fpage>–<lpage>391</lpage><pub-id pub-id-type="doi">10.3201/eid0804.010202</pub-id><pub-id pub-id-type="pmid">11971772</pub-id></mixed-citation></ref><ref id="B26"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tauxe</surname><given-names>R. V.</given-names></name></person-group> (<year>1997</year>). <article-title>Emerging foodborne diseases: an evolving public health challenge</article-title>. <source>Emerg. Infect. Dis</source>. <volume>3</volume>, <fpage>425</fpage>–<lpage>434</lpage><pub-id pub-id-type="doi">10.3201/eid0304.970403</pub-id><pub-id pub-id-type="pmid">9366593</pub-id></mixed-citation></ref><ref id="B27"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Threlfall</surname><given-names>E. J.</given-names></name></person-group> (<year>2000</year>). <article-title>Epidemic <italic>Salmonella</italic> typhimurium DT 104–a truly international multiresistant clone</article-title>. <source>J. Antimicrob. Chemother</source>. <volume>46</volume>, <fpage>7</fpage>–<lpage>10</lpage><pub-id pub-id-type="doi">10.1093/jac/46.1.7</pub-id><pub-id pub-id-type="pmid">10882682</pub-id></mixed-citation></ref><ref id="B28"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Turki</surname><given-names>Y.</given-names></name><name><surname>Ouzari</surname><given-names>H.</given-names></name><name><surname>Merhi</surname><given-names>I.</given-names></name><name><surname>Ben Aissa</surname><given-names>R.</given-names></name><name><surname>Hassen</surname><given-names>A.</given-names></name></person-group> (<year>2012</year>). <article-title>Biofilm formation, virulence gene and multi-drug resistance in <italic>Salmonella</italic> Kentucky isolated in Tunisia</article-title>. <source>Food Res. Int</source>. <volume>45</volume>, <fpage>940</fpage>–<lpage>946</lpage><pub-id pub-id-type="doi">10.1016/j.foodres.2011.05.031</pub-id></mixed-citation></ref><ref id="B29"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Walsh</surname><given-names>C.</given-names></name><name><surname>Fanning</surname><given-names>S.</given-names></name></person-group> (<year>2008</year>). <article-title>Antimicrobial Resistance in Foodborne Pathogens - A Cause for Concern?</article-title><source>Curr. Drug Targets</source>. <volume>9</volume>, <fpage>808</fpage>–<lpage>815</lpage><pub-id pub-id-type="doi">10.2174/138945008785747761</pub-id><pub-id pub-id-type="pmid">18781926</pub-id></mixed-citation></ref><ref id="B30"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wasyl</surname><given-names>D.</given-names></name><name><surname>Hoszowski</surname><given-names>A.</given-names></name></person-group> (<year>2012</year>). <article-title>First isolation of ESBL-producing <italic>Salmonella</italic> and emergence of multiresistant <italic>Salmonella</italic> Kentucky in turkey in Poland</article-title>. <source>Food Res. Int</source>. <volume>45</volume>, <fpage>958</fpage>–<lpage>961</lpage><pub-id pub-id-type="doi">10.1016/j.foodres.2011.07.024</pub-id></mixed-citation></ref><ref id="B31"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Weill</surname><given-names>F.-X.</given-names></name><name><surname>Guesnier</surname><given-names>F.</given-names></name><name><surname>Guibert</surname><given-names>V.</given-names></name><name><surname>Timinouni</surname><given-names>M.</given-names></name><name><surname>Demartin</surname><given-names>M.</given-names></name><name><surname>Polomack</surname><given-names>L.</given-names></name><etal></etal></person-group> (<year>2006a</year>). <article-title>Multidrug resistance in <italic>Salmonella</italic> enterica serotype Typhimurium from humans in France (1993 to 2003)</article-title>. <source>J. Clin. Microbiol</source>. <volume>44</volume>, <fpage>700</fpage>–<lpage>708</lpage><pub-id pub-id-type="doi">10.1128/JCM.44.3.700-708.2006</pub-id><pub-id pub-id-type="pmid">16517842</pub-id></mixed-citation></ref><ref id="B32"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Weill</surname><given-names>F.-X.</given-names></name><name><surname>Bertrand</surname><given-names>S.</given-names></name><name><surname>Guesnier</surname><given-names>F.</given-names></name><name><surname>Baucheron</surname><given-names>S.</given-names></name><name><surname>Cloeckaert</surname><given-names>A.</given-names></name><name><surname>Grimont</surname><given-names>P. A.</given-names></name></person-group> (<year>2006b</year>). <article-title>Ciprofloxacin-resistant <italic>Salmonella</italic> Kentucky in travelers</article-title>. <source>Emerg. Infect. Dis</source>. <volume>12</volume>, <fpage>1611</fpage>–<lpage>1612</lpage><pub-id pub-id-type="doi">10.3201/eid1210.060589</pub-id><pub-id pub-id-type="pmid">17176589</pub-id></mixed-citation></ref><ref id="B33"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Weill</surname><given-names>F.-X.</given-names></name><name><surname>Fabre</surname><given-names>L.</given-names></name><name><surname>Grandry</surname><given-names>B.</given-names></name><name><surname>Grimont</surname><given-names>P. A. D.</given-names></name><name><surname>Casin</surname><given-names>I.</given-names></name></person-group> (<year>2005</year>). <article-title>Multiple-antibiotic resistance in <italic>Salmonella enterica</italic> serotype Paratyphi B isolates collected in France between 2000 and 2003 is due mainly to strains harboring <italic>Salmonella</italic> genomic islands 1, 1-B, and 1-C</article-title>. <source>Antimicrob. Agents Chemother</source>. <volume>49</volume>, <fpage>2793</fpage>–<lpage>2801</lpage><pub-id pub-id-type="doi">10.1128/AAC.49.7.2793-2801.2005</pub-id><pub-id pub-id-type="pmid">15980351</pub-id></mixed-citation></ref><ref id="B34"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zając</surname><given-names>M.</given-names></name><name><surname>Wasyl</surname><given-names>D.</given-names></name><name><surname>Hoszowski</surname><given-names>A.</given-names></name><name><surname>Le Hello</surname><given-names>S.</given-names></name><name><surname>Szulowski</surname><given-names>K.</given-names></name></person-group> (<year>2013</year>). <article-title>Genetic lineages of <italic>Salmonella enterica</italic> serovar Kentucky spreading in pet reptiles</article-title>. <source>Vet. Microbiol</source>. <volume>166</volume>, <fpage>686</fpage>–<lpage>689</lpage><pub-id pub-id-type="doi">10.1016/j.vetmic.2013.07.023</pub-id><pub-id pub-id-type="pmid">23962467</pub-id></mixed-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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