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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association of Serum Vitamin D with the Risk of Incident Dementia and Subclinical Indices of Brain Aging: The Framingham Heart Study</title><author><name sortKey="Karakis, Ioannis" sort="Karakis, Ioannis" uniqKey="Karakis I" first="Ioannis" last="Karakis">Ioannis Karakis</name><affiliation><nlm:aff id="A1">Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA</nlm:aff></affiliation></author><author><name sortKey="Pase, Matthew P" sort="Pase, Matthew P" uniqKey="Pase M" first="Matthew P." last="Pase">Matthew P. Pase</name><affiliation><nlm:aff id="A2">Framingham Heart Study, Framingham, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia</nlm:aff></affiliation></author><author><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name><affiliation><nlm:aff id="A2">Framingham Heart Study, Framingham, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Booth, Sarah L" sort="Booth, Sarah L" uniqKey="Booth S" first="Sarah L." last="Booth">Sarah L. Booth</name><affiliation><nlm:aff id="A6">Jean Mayer-U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Jacques, Paul F" sort="Jacques, Paul F" uniqKey="Jacques P" first="Paul F." last="Jacques">Paul F. Jacques</name><affiliation><nlm:aff id="A6">Jean Mayer-U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Rogers, Gail" sort="Rogers, Gail" uniqKey="Rogers G" first="Gail" last="Rogers">Gail Rogers</name><affiliation><nlm:aff id="A6">Jean Mayer-U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name><affiliation><nlm:aff id="A7">Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience, University of California, Davis, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Vasan, Ramachandran S" sort="Vasan, Ramachandran S" uniqKey="Vasan R" first="Ramachandran S." last="Vasan">Ramachandran S. Vasan</name><affiliation><nlm:aff id="A2">Framingham Heart Study, Framingham, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Thomas J" sort="Wang, Thomas J" uniqKey="Wang T" first="Thomas J." last="Wang">Thomas J. Wang</name><affiliation><nlm:aff id="A8">Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Himali, Jayandra J" sort="Himali, Jayandra J" uniqKey="Himali J" first="Jayandra J." last="Himali">Jayandra J. Himali</name><affiliation><nlm:aff id="A2">Framingham Heart Study, Framingham, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Annweiler, Cedric" sort="Annweiler, Cedric" uniqKey="Annweiler C" first="Cedric" last="Annweiler">Cedric Annweiler</name><affiliation><nlm:aff id="A9">Department of Neuroscience, Division of Geriatric Medicine, University of Angers, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation><nlm:aff id="A2">Framingham Heart Study, Framingham, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26890771</idno><idno type="pmc">4911705</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911705</idno><idno type="RBID">PMC:4911705</idno><idno type="doi">10.3233/JAD-150991</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002215</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002215</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association of Serum Vitamin D with the Risk of Incident Dementia and Subclinical Indices of Brain Aging: The Framingham Heart Study</title><author><name sortKey="Karakis, Ioannis" sort="Karakis, Ioannis" uniqKey="Karakis I" first="Ioannis" last="Karakis">Ioannis Karakis</name><affiliation><nlm:aff id="A1">Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA</nlm:aff></affiliation></author><author><name sortKey="Pase, Matthew P" sort="Pase, Matthew P" uniqKey="Pase M" first="Matthew P." last="Pase">Matthew P. Pase</name><affiliation><nlm:aff id="A2">Framingham Heart Study, Framingham, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia</nlm:aff></affiliation></author><author><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name><affiliation><nlm:aff id="A2">Framingham Heart Study, Framingham, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Booth, Sarah L" sort="Booth, Sarah L" uniqKey="Booth S" first="Sarah L." last="Booth">Sarah L. Booth</name><affiliation><nlm:aff id="A6">Jean Mayer-U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Jacques, Paul F" sort="Jacques, Paul F" uniqKey="Jacques P" first="Paul F." last="Jacques">Paul F. Jacques</name><affiliation><nlm:aff id="A6">Jean Mayer-U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Rogers, Gail" sort="Rogers, Gail" uniqKey="Rogers G" first="Gail" last="Rogers">Gail Rogers</name><affiliation><nlm:aff id="A6">Jean Mayer-U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name><affiliation><nlm:aff id="A7">Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience, University of California, Davis, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Vasan, Ramachandran S" sort="Vasan, Ramachandran S" uniqKey="Vasan R" first="Ramachandran S." last="Vasan">Ramachandran S. Vasan</name><affiliation><nlm:aff id="A2">Framingham Heart Study, Framingham, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Thomas J" sort="Wang, Thomas J" uniqKey="Wang T" first="Thomas J." last="Wang">Thomas J. Wang</name><affiliation><nlm:aff id="A8">Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Himali, Jayandra J" sort="Himali, Jayandra J" uniqKey="Himali J" first="Jayandra J." last="Himali">Jayandra J. Himali</name><affiliation><nlm:aff id="A2">Framingham Heart Study, Framingham, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Annweiler, Cedric" sort="Annweiler, Cedric" uniqKey="Annweiler C" first="Cedric" last="Annweiler">Cedric Annweiler</name><affiliation><nlm:aff id="A9">Department of Neuroscience, Division of Geriatric Medicine, University of Angers, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation><nlm:aff id="A2">Framingham Heart Study, Framingham, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Alzheimer's disease : JAD</title><idno type="ISSN">1387-2877</idno><idno type="eISSN">1875-8908</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Identifying nutrition- and lifestyle-based risk factors for cognitive impairment and dementia may aid future primary prevention efforts.</p></sec><sec id="S2"><title>Objective</title><p id="P2">We aimed to examine the association of serum vitamin D levels with incident all-cause dementia, clinically characterized Alzheimer’s disease (AD), MRI markers of brain aging, and neuropsychological function.</p></sec><sec id="S3"><title>Methods</title><p id="P3">Framingham Heart Study participants had baseline serum 25-hydroxyvitamin D (25(OH)D) concentrations measured between 1986 and 2001. Vitamin D status was considered both as a continuous variable and dichotomized as deficient (<10 ng/mL), or at the cohort-specific 20th and 80th percentiles. Vitamin D was related to the 9-year risk of incident dementia (<italic>n</italic>= 1663), multiple neuropsychological tests (<italic>n</italic>= 1291) and MRI markers of brain volume, white matter hyperintensities and silent cerebral infarcts (<italic>n</italic> = 1139).</p></sec><sec id="S4"><title>Results</title><p id="P4">In adjusted models, participants with vitamin D deficiency (<italic>n</italic> = 104, 8% of the cognitive sample) displayed poorer performance on Trail Making B-A (β = −0.03 to −0.05 ±0.02) and the Hooper Visual Organization Test (β = −0.09 to −0.12 ±0.05), indicating poorer executive function, processing speed, and visuo-perceptual skills. These associations remained when vitamin D was examined as a continuous variable or dichotomized at the cohort specific 20th percentile. Vitamin D deficiency was also associated with lower hippocampal volumes (β = −0.01 ±0.01) but not total brain volume, white matter hyperintensities, or silent brain infarcts. No association was found between vitamin D deficiency and incident all-cause dementia or clinically characterized AD.</p></sec><sec id="S5"><title>Conclusions</title><p id="P5">In this large community-based sample, low 25(OH)D concentrations were associated with smaller hippocampal volume and poorer neuropsychological function.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9814863</journal-id><journal-id journal-id-type="pubmed-jr-id">21942</journal-id><journal-id journal-id-type="nlm-ta">J Alzheimers Dis</journal-id><journal-id journal-id-type="iso-abbrev">J. Alzheimers Dis.</journal-id><journal-title-group><journal-title>Journal of Alzheimer's disease : JAD</journal-title></journal-title-group><issn pub-type="ppub">1387-2877</issn><issn pub-type="epub">1875-8908</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26890771</article-id><article-id pub-id-type="pmc">4911705</article-id><article-id pub-id-type="doi">10.3233/JAD-150991</article-id><article-id pub-id-type="manuscript">NIHMS787465</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Association of Serum Vitamin D with the Risk of Incident Dementia and Subclinical Indices of Brain Aging: The Framingham Heart Study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Karakis</surname><given-names>Ioannis</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Pase</surname><given-names>Matthew P.</given-names></name><xref ref-type="aff" rid="A2">b</xref><xref ref-type="aff" rid="A3">c</xref><xref ref-type="aff" rid="A4">d</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Beiser</surname><given-names>Alexa</given-names></name><xref ref-type="aff" rid="A2">b</xref><xref ref-type="aff" rid="A3">c</xref><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Booth</surname><given-names>Sarah L.</given-names></name><xref ref-type="aff" rid="A6">f</xref></contrib><contrib contrib-type="author"><name><surname>Jacques</surname><given-names>Paul F.</given-names></name><xref ref-type="aff" rid="A6">f</xref></contrib><contrib contrib-type="author"><name><surname>Rogers</surname><given-names>Gail</given-names></name><xref ref-type="aff" rid="A6">f</xref></contrib><contrib contrib-type="author"><name><surname>DeCarli</surname><given-names>Charles</given-names></name><xref ref-type="aff" rid="A7">g</xref></contrib><contrib contrib-type="author"><name><surname>Vasan</surname><given-names>Ramachandran S.</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Thomas J.</given-names></name><xref ref-type="aff" rid="A8">h</xref></contrib><contrib contrib-type="author"><name><surname>Himali</surname><given-names>Jayandra J.</given-names></name><xref ref-type="aff" rid="A2">b</xref><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Annweiler</surname><given-names>Cedric</given-names></name><xref ref-type="aff" rid="A9">i</xref><xref ref-type="aff" rid="A10">j</xref></contrib><contrib contrib-type="author"><name><surname>Seshadri</surname><given-names>Sudha</given-names></name><xref ref-type="aff" rid="A2">b</xref><xref ref-type="aff" rid="A3">c</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="A1"><label>a</label>Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA</aff><aff id="A2"><label>b</label>Framingham Heart Study, Framingham, MA, USA</aff><aff id="A3"><label>c</label>Department of Neurology, Boston University School of Medicine, Boston, MA, USA</aff><aff id="A4"><label>d</label>Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia</aff><aff id="A5"><label>e</label>Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</aff><aff id="A6"><label>f</label>Jean Mayer-U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA</aff><aff id="A7"><label>g</label>Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience, University of California, Davis, CA, USA</aff><aff id="A8"><label>h</label>Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA</aff><aff id="A9"><label>i</label>Department of Neuroscience, Division of Geriatric Medicine, University of Angers, France</aff><aff id="A10"><label>j</label>Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada</aff><author-notes><corresp id="cor1"><label>*</label>Correspondence to: Dr. Sudha Seshadri and Dr. Matthew P. Pase, Department of Neurology, Boston University School of Medicine, B602, 72 East Concord Street, Boston, MA 02118, USA. Tel.: + 1 617 414 1337; Fax: + 1 617 638 8086; <email>suseshad@bu.edu</email> (Dr. S. Seshadri); Tel.:+ 1 617 638 8064; Fax: + 1 617 638 8086; <email>matthewpase@gmail.com</email> (Dr. M.P. Pase)</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>20</day><month>5</month><year>2016</year></pub-date><pub-date pub-type="ppub"><day>6</day><month>2</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>17</day><month>6</month><year>2016</year></pub-date><volume>51</volume><issue>2</issue><fpage>451</fpage><lpage>461</lpage><pmc-comment>elocation-id from pubmed: 10.3233/JAD-150991</pmc-comment>
<abstract><sec id="S1"><title>Background</title><p id="P1">Identifying nutrition- and lifestyle-based risk factors for cognitive impairment and dementia may aid future primary prevention efforts.</p></sec><sec id="S2"><title>Objective</title><p id="P2">We aimed to examine the association of serum vitamin D levels with incident all-cause dementia, clinically characterized Alzheimer’s disease (AD), MRI markers of brain aging, and neuropsychological function.</p></sec><sec id="S3"><title>Methods</title><p id="P3">Framingham Heart Study participants had baseline serum 25-hydroxyvitamin D (25(OH)D) concentrations measured between 1986 and 2001. Vitamin D status was considered both as a continuous variable and dichotomized as deficient (<10 ng/mL), or at the cohort-specific 20th and 80th percentiles. Vitamin D was related to the 9-year risk of incident dementia (<italic>n</italic>= 1663), multiple neuropsychological tests (<italic>n</italic>= 1291) and MRI markers of brain volume, white matter hyperintensities and silent cerebral infarcts (<italic>n</italic> = 1139).</p></sec><sec id="S4"><title>Results</title><p id="P4">In adjusted models, participants with vitamin D deficiency (<italic>n</italic> = 104, 8% of the cognitive sample) displayed poorer performance on Trail Making B-A (β = −0.03 to −0.05 ±0.02) and the Hooper Visual Organization Test (β = −0.09 to −0.12 ±0.05), indicating poorer executive function, processing speed, and visuo-perceptual skills. These associations remained when vitamin D was examined as a continuous variable or dichotomized at the cohort specific 20th percentile. Vitamin D deficiency was also associated with lower hippocampal volumes (β = −0.01 ±0.01) but not total brain volume, white matter hyperintensities, or silent brain infarcts. No association was found between vitamin D deficiency and incident all-cause dementia or clinically characterized AD.</p></sec><sec id="S5"><title>Conclusions</title><p id="P5">In this large community-based sample, low 25(OH)D concentrations were associated with smaller hippocampal volume and poorer neuropsychological function.</p></sec></abstract><kwd-group><kwd>Alzheimer’s disease</kwd><kwd>brain</kwd><kwd>dementia</kwd><kwd>diet</kwd><kwd>lifestyle</kwd><kwd>magnetic resonance imaging</kwd><kwd>neuropsychology</kwd><kwd>nutritional status</kwd><kwd>risk factors</kwd><kwd>vitamin D</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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