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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">GWAS for executive function and processing speed suggests involvement of the
<italic>CADM2</italic> gene</title><author><name sortKey="Ibrahim Verbaas, Ca" sort="Ibrahim Verbaas, Ca" uniqKey="Ibrahim Verbaas C" first="Ca" last="Ibrahim-Verbaas">Ca Ibrahim-Verbaas</name><affiliation><nlm:aff id="A1">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Bressler, J" sort="Bressler, J" uniqKey="Bressler J" first="J" last="Bressler">J. Bressler</name><affiliation><nlm:aff id="A3">Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Debette, S" sort="Debette, S" uniqKey="Debette S" first="S" last="Debette">S. Debette</name><affiliation><nlm:aff id="A4">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Institut National de la Santé et de la Recherche Médicale (INSERM), U897, Epidemiology and Biostatistics, University of Bordeaux, Bordeaux, France</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Department of Neurology, Bordeaux University Hospital, Bordeaux, France</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Schuur, M" sort="Schuur, M" uniqKey="Schuur M" first="M" last="Schuur">M. Schuur</name><affiliation><nlm:aff id="A1">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Smith, Av" sort="Smith, Av" uniqKey="Smith A" first="Av" last="Smith">Av Smith</name><affiliation><nlm:aff id="A7">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Bis, Jc" sort="Bis, Jc" uniqKey="Bis J" first="Jc" last="Bis">Jc Bis</name><affiliation><nlm:aff id="A9">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Davies, G" sort="Davies, G" uniqKey="Davies G" first="G" last="Davies">G. Davies</name><affiliation><nlm:aff id="A10">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Trompet, S" sort="Trompet, S" uniqKey="Trompet S" first="S" last="Trompet">S. Trompet</name><affiliation><nlm:aff id="A11">Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Smith, Ja" sort="Smith, Ja" uniqKey="Smith J" first="Ja" last="Smith">Ja Smith</name><affiliation><nlm:aff id="A13">Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA</nlm:aff></affiliation></author><author><name sortKey="Wolf, C" sort="Wolf, C" uniqKey="Wolf C" first="C" last="Wolf">C. Wolf</name><affiliation><nlm:aff id="A14">RG Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Chibnik, Lb" sort="Chibnik, Lb" uniqKey="Chibnik L" first="Lb" last="Chibnik">Lb Chibnik</name><affiliation><nlm:aff id="A15">Program in Translational Neuropsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Liu, Y" sort="Liu, Y" uniqKey="Liu Y" first="Y" last="Liu">Y. Liu</name><affiliation><nlm:aff id="A16">Department of Epidemiology, Wake Forest School of Medicine, Winston-Salem, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Vitart, V" sort="Vitart, V" uniqKey="Vitart V" first="V" last="Vitart">V. Vitart</name><affiliation><nlm:aff id="A17">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Kirin, M" sort="Kirin, M" uniqKey="Kirin M" first="M" last="Kirin">M. Kirin</name><affiliation><nlm:aff id="A18">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Petrovic, K" sort="Petrovic, K" uniqKey="Petrovic K" first="K" last="Petrovic">K. Petrovic</name><affiliation><nlm:aff id="A19">Department of Neurology, Medical University and General Hospital of Graz, Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Polasek, O" sort="Polasek, O" uniqKey="Polasek O" first="O" last="Polasek">O. Polasek</name><affiliation><nlm:aff id="A20">Department of Public Health, University of Split, Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Zgaga, L" sort="Zgaga, L" uniqKey="Zgaga L" first="L" last="Zgaga">L. Zgaga</name><affiliation><nlm:aff id="A21">Department of Public Health and Primary Care, Trinity College Dublin, Dublin, Ireland</nlm:aff></affiliation></author><author><name sortKey="Fawns Ritchie, C" sort="Fawns Ritchie, C" uniqKey="Fawns Ritchie C" first="C" last="Fawns-Ritchie">C. Fawns-Ritchie</name><affiliation><nlm:aff id="A10">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Hoffmann, P" sort="Hoffmann, P" uniqKey="Hoffmann P" first="P" last="Hoffmann">P. Hoffmann</name><affiliation><nlm:aff id="A22">Institute of Neuroscience and Medicine (INM -1), Research Center Juelich, Juelich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Department of Genomics, Life and Brain Research Center, Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Karjalainen, J" sort="Karjalainen, J" uniqKey="Karjalainen J" first="J" last="Karjalainen">J. Karjalainen</name><affiliation><nlm:aff id="A25">Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Lahti, J" sort="Lahti, J" uniqKey="Lahti J" first="J" last="Lahti">J. Lahti</name><affiliation><nlm:aff id="A26">Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Folkhälsan Research Centre, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Llewellyn, Dj" sort="Llewellyn, Dj" uniqKey="Llewellyn D" first="Dj" last="Llewellyn">Dj Llewellyn</name><affiliation><nlm:aff id="A28">Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, UK</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Co" sort="Schmidt, Co" uniqKey="Schmidt C" first="Co" last="Schmidt">Co Schmidt</name><affiliation><nlm:aff id="A29">Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Mather, Ka" sort="Mather, Ka" uniqKey="Mather K" first="Ka" last="Mather">Ka Mather</name><affiliation><nlm:aff id="A30">Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Chouraki, V" sort="Chouraki, V" uniqKey="Chouraki V" first="V" last="Chouraki">V. Chouraki</name><affiliation><nlm:aff id="A31">Inserm, U1167, Institut Pasteur de Lille, Université Lille-Nord de France, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Sun, Q" sort="Sun, Q" uniqKey="Sun Q" first="Q" last="Sun">Q. Sun</name><affiliation><nlm:aff id="A32">Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Resnick, Sm" sort="Resnick, Sm" uniqKey="Resnick S" first="Sm" last="Resnick">Sm Resnick</name><affiliation><nlm:aff id="A33">Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Rose, Lm" sort="Rose, Lm" uniqKey="Rose L" first="Lm" last="Rose">Lm Rose</name><affiliation><nlm:aff id="A34">Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Oldmeadow, C" sort="Oldmeadow, C" uniqKey="Oldmeadow C" first="C" last="Oldmeadow">C. Oldmeadow</name><affiliation><nlm:aff id="A35">Hunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Stewart, M" sort="Stewart, M" uniqKey="Stewart M" first="M" last="Stewart">M. Stewart</name><affiliation><nlm:aff id="A18">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Smith, Bh" sort="Smith, Bh" uniqKey="Smith B" first="Bh" last="Smith">Bh Smith</name><affiliation><nlm:aff id="A36">Medical Research Institute, University of Dundee, Dundee, UK</nlm:aff></affiliation></author><author><name sortKey="Gudnason, V" sort="Gudnason, V" uniqKey="Gudnason V" first="V" last="Gudnason">V. Gudnason</name><affiliation><nlm:aff id="A7">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Yang, Q" sort="Yang, Q" uniqKey="Yang Q" first="Q" last="Yang">Q. Yang</name><affiliation><nlm:aff id="A37">The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Mirza, Ss" sort="Mirza, Ss" uniqKey="Mirza S" first="Ss" last="Mirza">Ss Mirza</name><affiliation><nlm:aff id="A39">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Jukema, Jw" sort="Jukema, Jw" uniqKey="Jukema J" first="Jw" last="Jukema">Jw Jukema</name><affiliation><nlm:aff id="A11">Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Dejager, Pl" sort="Dejager, Pl" uniqKey="Dejager P" first="Pl" last="Dejager">Pl Dejager</name><affiliation><nlm:aff id="A15">Program in Translational Neuropsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Harris, Tb" sort="Harris, Tb" uniqKey="Harris T" first="Tb" last="Harris">Tb Harris</name><affiliation><nlm:aff id="A41">Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Liewald, Dc" sort="Liewald, Dc" uniqKey="Liewald D" first="Dc" last="Liewald">Dc Liewald</name><affiliation><nlm:aff id="A10">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Department of Psychology, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Amin, N" sort="Amin, N" uniqKey="Amin N" first="N" last="Amin">N. Amin</name><affiliation><nlm:aff id="A1">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Coker, Lh" sort="Coker, Lh" uniqKey="Coker L" first="Lh" last="Coker">Lh Coker</name><affiliation><nlm:aff id="A43">Division of Public Health Sciences and Neurology, Wake Forest School of Medicine, Winston-Salem, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Stegle, O" sort="Stegle, O" uniqKey="Stegle O" first="O" last="Stegle">O. Stegle</name><affiliation><nlm:aff id="A44">Max Planck Institute for Developmental Biology, Max Planck Institute for Intelligent Systems, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Lopez, Ol" sort="Lopez, Ol" uniqKey="Lopez O" first="Ol" last="Lopez">Ol Lopez</name><affiliation><nlm:aff id="A45">Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Schmidt, R" sort="Schmidt, R" uniqKey="Schmidt R" first="R" last="Schmidt">R. Schmidt</name><affiliation><nlm:aff id="A19">Department of Neurology, Medical University and General Hospital of Graz, Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Teumer, A" sort="Teumer, A" uniqKey="Teumer A" first="A" last="Teumer">A. Teumer</name><affiliation><nlm:aff id="A46">Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Ford, I" sort="Ford, I" uniqKey="Ford I" first="I" last="Ford">I. Ford</name><affiliation><nlm:aff id="A47">Robertson Center for biostatistics, University of Glasgow, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Karbalai, N" sort="Karbalai, N" uniqKey="Karbalai N" first="N" last="Karbalai">N. Karbalai</name><affiliation><nlm:aff id="A14">RG Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Becker, Jt" sort="Becker, Jt" uniqKey="Becker J" first="Jt" last="Becker">Jt Becker</name><affiliation><nlm:aff id="A45">Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Jonsdottir, Mk" sort="Jonsdottir, Mk" uniqKey="Jonsdottir M" first="Mk" last="Jonsdottir">Mk Jonsdottir</name><affiliation><nlm:aff id="A50">Landspitali Hospital, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Au, R" sort="Au, R" uniqKey="Au R" first="R" last="Au">R. Au</name><affiliation><nlm:aff id="A4">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A37">The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Fehrmann, Rsn" sort="Fehrmann, Rsn" uniqKey="Fehrmann R" first="Rsn" last="Fehrmann">Rsn Fehrmann</name><affiliation><nlm:aff id="A25">Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Herms, S" sort="Herms, S" uniqKey="Herms S" first="S" last="Herms">S. Herms</name><affiliation><nlm:aff id="A23">Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Department of Genomics, Life and Brain Research Center, Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Nalls, M" sort="Nalls, M" uniqKey="Nalls M" first="M" last="Nalls">M. Nalls</name><affiliation><nlm:aff id="A51">Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Zhao, W" sort="Zhao, W" uniqKey="Zhao W" first="W" last="Zhao">W. Zhao</name><affiliation><nlm:aff id="A13">Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA</nlm:aff></affiliation></author><author><name sortKey="Turner, St" sort="Turner, St" uniqKey="Turner S" first="St" last="Turner">St Turner</name><affiliation><nlm:aff id="A52">Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Yaffe, K" sort="Yaffe, K" uniqKey="Yaffe K" first="K" last="Yaffe">K. Yaffe</name><affiliation><nlm:aff id="A53">Departments of Psychiatry, Neurology and Epidemiology, University of California, San Francisco and San Francisco VA Medical Center, San Francisco, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Lohman, K" sort="Lohman, K" uniqKey="Lohman K" first="K" last="Lohman">K. Lohman</name><affiliation><nlm:aff id="A16">Department of Epidemiology, Wake Forest School of Medicine, Winston-Salem, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Van Swieten, Jc" sort="Van Swieten, Jc" uniqKey="Van Swieten J" first="Jc" last="Van Swieten">Jc Van Swieten</name><affiliation><nlm:aff id="A2">Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kardia, Slr" sort="Kardia, Slr" uniqKey="Kardia S" first="Slr" last="Kardia">Slr Kardia</name><affiliation><nlm:aff id="A13">Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA</nlm:aff></affiliation></author><author><name sortKey="Knopman, Ds" sort="Knopman, Ds" uniqKey="Knopman D" first="Ds" last="Knopman">Ds Knopman</name><affiliation><nlm:aff id="A54">Department of Neurology, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Meeks, Wm" sort="Meeks, Wm" uniqKey="Meeks W" first="Wm" last="Meeks">Wm Meeks</name><affiliation><nlm:aff id="A55">Department of Medicine, Division of Geriatrics, University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff></affiliation></author><author><name sortKey="Heiss, G" sort="Heiss, G" uniqKey="Heiss G" first="G" last="Heiss">G. Heiss</name><affiliation><nlm:aff id="A56">Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Holliday, Eg" sort="Holliday, Eg" uniqKey="Holliday E" first="Eg" last="Holliday">Eg Holliday</name><affiliation><nlm:aff id="A35">Hunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Schofield, Pw" sort="Schofield, Pw" uniqKey="Schofield P" first="Pw" last="Schofield">Pw Schofield</name><affiliation><nlm:aff id="A57">School of Medicine and Public Health, Faculty of Health, University of Newcastle, Newcastle, SW, Australia</nlm:aff></affiliation></author><author><name sortKey="Tanaka, T" sort="Tanaka, T" uniqKey="Tanaka T" first="T" last="Tanaka">T. Tanaka</name><affiliation><nlm:aff id="A58">Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Stott, Dj" sort="Stott, Dj" uniqKey="Stott D" first="Dj" last="Stott">Dj Stott</name><affiliation><nlm:aff id="A59">Department of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Wang, J" sort="Wang, J" uniqKey="Wang J" first="J" last="Wang">J. Wang</name><affiliation><nlm:aff id="A38">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Ridker, P" sort="Ridker, P" uniqKey="Ridker P" first="P" last="Ridker">P. Ridker</name><affiliation><nlm:aff id="A34">Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Gow, Aj" sort="Gow, Aj" uniqKey="Gow A" first="Aj" last="Gow">Aj Gow</name><affiliation><nlm:aff id="A10">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Department of Psychology, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Pattie, A" sort="Pattie, A" uniqKey="Pattie A" first="A" last="Pattie">A. Pattie</name><affiliation><nlm:aff id="A10">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Starr, Jm" sort="Starr, Jm" uniqKey="Starr J" first="Jm" last="Starr">Jm Starr</name><affiliation><nlm:aff id="A10">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A60">Alzheimer Scotland Research Centre, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Hocking, Lj" sort="Hocking, Lj" uniqKey="Hocking L" first="Lj" last="Hocking">Lj Hocking</name><affiliation><nlm:aff id="A61">Division of Applied Medicine, University of Aberdeen, Aberdeen, UK</nlm:aff></affiliation></author><author><name sortKey="Armstrong, Nj" sort="Armstrong, Nj" uniqKey="Armstrong N" first="Nj" last="Armstrong">Nj Armstrong</name><affiliation><nlm:aff id="A30">Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A63">School of Mathematics & Statistics and Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Mclachlan, S" sort="Mclachlan, S" uniqKey="Mclachlan S" first="S" last="Mclachlan">S. Mclachlan</name><affiliation><nlm:aff id="A18">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Shulman, Jm" sort="Shulman, Jm" uniqKey="Shulman J" first="Jm" last="Shulman">Jm Shulman</name><affiliation><nlm:aff id="A64">Department of Neurology, Baylor College of Medicine, Houston, TX, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Department of Molecular and Human Genetics, The Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Pilling, Lc" sort="Pilling, Lc" uniqKey="Pilling L" first="Lc" last="Pilling">Lc Pilling</name><affiliation><nlm:aff id="A66">Epidemiology and Public Health Group, University of Exeter Medical School, Exeter, UK</nlm:aff></affiliation></author><author><name sortKey="Eiriksdottir, G" sort="Eiriksdottir, G" uniqKey="Eiriksdottir G" first="G" last="Eiriksdottir">G. Eiriksdottir</name><affiliation><nlm:aff id="A7">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation></author><author><name sortKey="Scott, Rj" sort="Scott, Rj" uniqKey="Scott R" first="Rj" last="Scott">Rj Scott</name><affiliation><nlm:aff id="A35">Hunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Kochan, Na" sort="Kochan, Na" uniqKey="Kochan N" first="Na" last="Kochan">Na Kochan</name><affiliation><nlm:aff id="A30">Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Neuropsychiatric Institute, The Prince of Wales Hospital, Sydney, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Palotie, A" sort="Palotie, A" uniqKey="Palotie A" first="A" last="Palotie">A. Palotie</name><affiliation><nlm:aff id="A68">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A69">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A70">Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Hsieh, Y C" sort="Hsieh, Y C" uniqKey="Hsieh Y" first="Y-C" last="Hsieh">Y-C Hsieh</name><affiliation><nlm:aff id="A71">School of Public Health, Taipei Medical University, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Jg" sort="Eriksson, Jg" uniqKey="Eriksson J" first="Jg" last="Eriksson">Jg Eriksson</name><affiliation><nlm:aff id="A27">Folkhälsan Research Centre, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A73">National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A74">Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A75">Vasa Central Hospital, Vasa, Finland</nlm:aff></affiliation></author><author><name sortKey="Penman, A" sort="Penman, A" uniqKey="Penman A" first="A" last="Penman">A. Penman</name><affiliation><nlm:aff id="A76">Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff></affiliation></author><author><name sortKey="Gottesman, Rf" sort="Gottesman, Rf" uniqKey="Gottesman R" first="Rf" last="Gottesman">Rf Gottesman</name><affiliation><nlm:aff id="A77">Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Oostra, Ba" sort="Oostra, Ba" uniqKey="Oostra B" first="Ba" last="Oostra">Ba Oostra</name><affiliation><nlm:aff id="A1">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Yu, L" sort="Yu, L" uniqKey="Yu L" first="L" last="Yu">L. Yu</name><affiliation><nlm:aff id="A78">Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Destefano, Al" sort="Destefano, Al" uniqKey="Destefano A" first="Al" last="Destefano">Al Destefano</name><affiliation><nlm:aff id="A4">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A37">The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Beiser, A" sort="Beiser, A" uniqKey="Beiser A" first="A" last="Beiser">A. Beiser</name><affiliation><nlm:aff id="A4">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A37">The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Garcia, M" sort="Garcia, M" uniqKey="Garcia M" first="M" last="Garcia">M. Garcia</name><affiliation><nlm:aff id="A41">Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Rotter, Ji" sort="Rotter, Ji" uniqKey="Rotter J" first="Ji" last="Rotter">Ji Rotter</name><affiliation><nlm:aff id="A79">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A80">Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A81">Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Nothen, Mm" sort="Nothen, Mm" uniqKey="Nothen M" first="Mm" last="Nöthen">Mm Nöthen</name><affiliation><nlm:aff id="A24">Department of Genomics, Life and Brain Research Center, Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A82">German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Hofman, A" sort="Hofman, A" uniqKey="Hofman A" first="A" last="Hofman">A. Hofman</name><affiliation><nlm:aff id="A39">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Slagboom, Pe" sort="Slagboom, Pe" uniqKey="Slagboom P" first="Pe" last="Slagboom">Pe Slagboom</name><affiliation><nlm:aff id="A83">Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Westendorp, Rgj" sort="Westendorp, Rgj" uniqKey="Westendorp R" first="Rgj" last="Westendorp">Rgj Westendorp</name><affiliation><nlm:aff id="A84">Leiden Academy of Vitality and Ageing, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Buckley, Bm" sort="Buckley, Bm" uniqKey="Buckley B" first="Bm" last="Buckley">Bm Buckley</name><affiliation><nlm:aff id="A85">Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland</nlm:aff></affiliation></author><author><name sortKey="Wolf, Pa" sort="Wolf, Pa" uniqKey="Wolf P" first="Pa" last="Wolf">Pa Wolf</name><affiliation><nlm:aff id="A4">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A37">The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Ag" sort="Uitterlinden, Ag" uniqKey="Uitterlinden A" first="Ag" last="Uitterlinden">Ag Uitterlinden</name><affiliation><nlm:aff id="A39">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A86">Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Psaty, Bm" sort="Psaty, Bm" uniqKey="Psaty B" first="Bm" last="Psaty">Bm Psaty</name><affiliation><nlm:aff id="A9">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A88">Department of Health Services, University of Washington, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A89">Group Health Research Institute, Group Health, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Grabe, Hj" sort="Grabe, Hj" uniqKey="Grabe H" first="Hj" last="Grabe">Hj Grabe</name><affiliation><nlm:aff id="A90">Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS-Hospital Stralsund, Stralsund, Germany</nlm:aff></affiliation></author><author><name sortKey="Bandinelli, S" sort="Bandinelli, S" uniqKey="Bandinelli S" first="S" last="Bandinelli">S. Bandinelli</name><affiliation><nlm:aff id="A91">Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Chasman, Di" sort="Chasman, Di" uniqKey="Chasman D" first="Di" last="Chasman">Di Chasman</name><affiliation><nlm:aff id="A34">Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Grodstein, F" sort="Grodstein, F" uniqKey="Grodstein F" first="F" last="Grodstein">F. Grodstein</name><affiliation><nlm:aff id="A32">Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="R Ikkonen, K" sort="R Ikkonen, K" uniqKey="R Ikkonen K" first="K" last="R Ikkönen">K. R Ikkönen</name><affiliation><nlm:aff id="A26">Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Lambert, J C" sort="Lambert, J C" uniqKey="Lambert J" first="J-C" last="Lambert">J-C Lambert</name><affiliation><nlm:aff id="A31">Inserm, U1167, Institut Pasteur de Lille, Université Lille-Nord de France, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Porteous, Dj" sort="Porteous, Dj" uniqKey="Porteous D" first="Dj" last="Porteous">Dj Porteous</name><affiliation><nlm:aff id="A92">Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Price, Jf" sort="Price, Jf" uniqKey="Price J" first="Jf" last="Price">Jf Price</name><affiliation><nlm:aff id="A18">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Sachdev, Ps" sort="Sachdev, Ps" uniqKey="Sachdev P" first="Ps" last="Sachdev">Ps Sachdev</name><affiliation><nlm:aff id="A30">Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Neuropsychiatric Institute, The Prince of Wales Hospital, Sydney, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Ferrucci, L" sort="Ferrucci, L" uniqKey="Ferrucci L" first="L" last="Ferrucci">L. Ferrucci</name><affiliation><nlm:aff id="A58">Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Attia, Jr" sort="Attia, Jr" uniqKey="Attia J" first="Jr" last="Attia">Jr Attia</name><affiliation><nlm:aff id="A35">Hunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Rudan, I" sort="Rudan, I" uniqKey="Rudan I" first="I" last="Rudan">I. Rudan</name><affiliation><nlm:aff id="A18">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Hayward, C" sort="Hayward, C" uniqKey="Hayward C" first="C" last="Hayward">C. Hayward</name><affiliation><nlm:aff id="A17">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Wright, Af" sort="Wright, Af" uniqKey="Wright A" first="Af" last="Wright">Af Wright</name><affiliation><nlm:aff id="A17">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Wilson, Jf" sort="Wilson, Jf" uniqKey="Wilson J" first="Jf" last="Wilson">Jf Wilson</name><affiliation><nlm:aff id="A18">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Cichon, S" sort="Cichon, S" uniqKey="Cichon S" first="S" last="Cichon">S. Cichon</name><affiliation><nlm:aff id="A23">Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Department of Genomics, Life and Brain Research Center, Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A93">Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany</nlm:aff></affiliation></author><author><name sortKey="Franke, L" sort="Franke, L" uniqKey="Franke L" first="L" last="Franke">L. Franke</name><affiliation><nlm:aff id="A25">Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Schmidt, H" sort="Schmidt, H" uniqKey="Schmidt H" first="H" last="Schmidt">H. Schmidt</name><affiliation><nlm:aff id="A19">Department of Neurology, Medical University and General Hospital of Graz, Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Ding, J" sort="Ding, J" uniqKey="Ding J" first="J" last="Ding">J. Ding</name><affiliation><nlm:aff id="A94">Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA</nlm:aff></affiliation></author><author><name sortKey="De Craen, Ajm" sort="De Craen, Ajm" uniqKey="De Craen A" first="Ajm" last="De Craen">Ajm De Craen</name><affiliation><nlm:aff id="A12">Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Fornage, M" sort="Fornage, M" uniqKey="Fornage M" first="M" last="Fornage">M. Fornage</name><affiliation><nlm:aff id="A95">Institute for Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Bennett, Da" sort="Bennett, Da" uniqKey="Bennett D" first="Da" last="Bennett">Da Bennett</name><affiliation><nlm:aff id="A78">Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Deary, Ij" sort="Deary, Ij" uniqKey="Deary I" first="Ij" last="Deary">Ij Deary</name><affiliation><nlm:aff id="A10">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Department of Psychology, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Ikram, Ma" sort="Ikram, Ma" uniqKey="Ikram M" first="Ma" last="Ikram">Ma Ikram</name><affiliation><nlm:aff id="A2">Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A96">Department of Radiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Launer, Lj" sort="Launer, Lj" uniqKey="Launer L" first="Lj" last="Launer">Lj Launer</name><affiliation><nlm:aff id="A41">Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Fitzpatrick, Al" sort="Fitzpatrick, Al" uniqKey="Fitzpatrick A" first="Al" last="Fitzpatrick">Al Fitzpatrick</name><affiliation><nlm:aff id="A87">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Seshadri, S" sort="Seshadri, S" uniqKey="Seshadri S" first="S" last="Seshadri">S. 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<italic>CADM2</italic> gene</title><author><name sortKey="Ibrahim Verbaas, Ca" sort="Ibrahim Verbaas, Ca" uniqKey="Ibrahim Verbaas C" first="Ca" last="Ibrahim-Verbaas">Ca Ibrahim-Verbaas</name><affiliation><nlm:aff id="A1">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Bressler, J" sort="Bressler, J" uniqKey="Bressler J" first="J" last="Bressler">J. Bressler</name><affiliation><nlm:aff id="A3">Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Debette, S" sort="Debette, S" uniqKey="Debette S" first="S" last="Debette">S. Debette</name><affiliation><nlm:aff id="A4">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Institut National de la Santé et de la Recherche Médicale (INSERM), U897, Epidemiology and Biostatistics, University of Bordeaux, Bordeaux, France</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Department of Neurology, Bordeaux University Hospital, Bordeaux, France</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Schuur, M" sort="Schuur, M" uniqKey="Schuur M" first="M" last="Schuur">M. Schuur</name><affiliation><nlm:aff id="A1">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Smith, Av" sort="Smith, Av" uniqKey="Smith A" first="Av" last="Smith">Av Smith</name><affiliation><nlm:aff id="A7">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Bis, Jc" sort="Bis, Jc" uniqKey="Bis J" first="Jc" last="Bis">Jc Bis</name><affiliation><nlm:aff id="A9">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Davies, G" sort="Davies, G" uniqKey="Davies G" first="G" last="Davies">G. Davies</name><affiliation><nlm:aff id="A10">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Trompet, S" sort="Trompet, S" uniqKey="Trompet S" first="S" last="Trompet">S. Trompet</name><affiliation><nlm:aff id="A11">Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Smith, Ja" sort="Smith, Ja" uniqKey="Smith J" first="Ja" last="Smith">Ja Smith</name><affiliation><nlm:aff id="A13">Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA</nlm:aff></affiliation></author><author><name sortKey="Wolf, C" sort="Wolf, C" uniqKey="Wolf C" first="C" last="Wolf">C. Wolf</name><affiliation><nlm:aff id="A14">RG Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Chibnik, Lb" sort="Chibnik, Lb" uniqKey="Chibnik L" first="Lb" last="Chibnik">Lb Chibnik</name><affiliation><nlm:aff id="A15">Program in Translational Neuropsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Liu, Y" sort="Liu, Y" uniqKey="Liu Y" first="Y" last="Liu">Y. Liu</name><affiliation><nlm:aff id="A16">Department of Epidemiology, Wake Forest School of Medicine, Winston-Salem, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Vitart, V" sort="Vitart, V" uniqKey="Vitart V" first="V" last="Vitart">V. Vitart</name><affiliation><nlm:aff id="A17">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Kirin, M" sort="Kirin, M" uniqKey="Kirin M" first="M" last="Kirin">M. Kirin</name><affiliation><nlm:aff id="A18">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Petrovic, K" sort="Petrovic, K" uniqKey="Petrovic K" first="K" last="Petrovic">K. Petrovic</name><affiliation><nlm:aff id="A19">Department of Neurology, Medical University and General Hospital of Graz, Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Polasek, O" sort="Polasek, O" uniqKey="Polasek O" first="O" last="Polasek">O. Polasek</name><affiliation><nlm:aff id="A20">Department of Public Health, University of Split, Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Zgaga, L" sort="Zgaga, L" uniqKey="Zgaga L" first="L" last="Zgaga">L. Zgaga</name><affiliation><nlm:aff id="A21">Department of Public Health and Primary Care, Trinity College Dublin, Dublin, Ireland</nlm:aff></affiliation></author><author><name sortKey="Fawns Ritchie, C" sort="Fawns Ritchie, C" uniqKey="Fawns Ritchie C" first="C" last="Fawns-Ritchie">C. Fawns-Ritchie</name><affiliation><nlm:aff id="A10">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Hoffmann, P" sort="Hoffmann, P" uniqKey="Hoffmann P" first="P" last="Hoffmann">P. Hoffmann</name><affiliation><nlm:aff id="A22">Institute of Neuroscience and Medicine (INM -1), Research Center Juelich, Juelich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Department of Genomics, Life and Brain Research Center, Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Karjalainen, J" sort="Karjalainen, J" uniqKey="Karjalainen J" first="J" last="Karjalainen">J. Karjalainen</name><affiliation><nlm:aff id="A25">Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Lahti, J" sort="Lahti, J" uniqKey="Lahti J" first="J" last="Lahti">J. Lahti</name><affiliation><nlm:aff id="A26">Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Folkhälsan Research Centre, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Llewellyn, Dj" sort="Llewellyn, Dj" uniqKey="Llewellyn D" first="Dj" last="Llewellyn">Dj Llewellyn</name><affiliation><nlm:aff id="A28">Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, UK</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Co" sort="Schmidt, Co" uniqKey="Schmidt C" first="Co" last="Schmidt">Co Schmidt</name><affiliation><nlm:aff id="A29">Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Mather, Ka" sort="Mather, Ka" uniqKey="Mather K" first="Ka" last="Mather">Ka Mather</name><affiliation><nlm:aff id="A30">Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Chouraki, V" sort="Chouraki, V" uniqKey="Chouraki V" first="V" last="Chouraki">V. Chouraki</name><affiliation><nlm:aff id="A31">Inserm, U1167, Institut Pasteur de Lille, Université Lille-Nord de France, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Sun, Q" sort="Sun, Q" uniqKey="Sun Q" first="Q" last="Sun">Q. Sun</name><affiliation><nlm:aff id="A32">Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Resnick, Sm" sort="Resnick, Sm" uniqKey="Resnick S" first="Sm" last="Resnick">Sm Resnick</name><affiliation><nlm:aff id="A33">Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Rose, Lm" sort="Rose, Lm" uniqKey="Rose L" first="Lm" last="Rose">Lm Rose</name><affiliation><nlm:aff id="A34">Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Oldmeadow, C" sort="Oldmeadow, C" uniqKey="Oldmeadow C" first="C" last="Oldmeadow">C. Oldmeadow</name><affiliation><nlm:aff id="A35">Hunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Stewart, M" sort="Stewart, M" uniqKey="Stewart M" first="M" last="Stewart">M. Stewart</name><affiliation><nlm:aff id="A18">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Smith, Bh" sort="Smith, Bh" uniqKey="Smith B" first="Bh" last="Smith">Bh Smith</name><affiliation><nlm:aff id="A36">Medical Research Institute, University of Dundee, Dundee, UK</nlm:aff></affiliation></author><author><name sortKey="Gudnason, V" sort="Gudnason, V" uniqKey="Gudnason V" first="V" last="Gudnason">V. Gudnason</name><affiliation><nlm:aff id="A7">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Yang, Q" sort="Yang, Q" uniqKey="Yang Q" first="Q" last="Yang">Q. Yang</name><affiliation><nlm:aff id="A37">The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Mirza, Ss" sort="Mirza, Ss" uniqKey="Mirza S" first="Ss" last="Mirza">Ss Mirza</name><affiliation><nlm:aff id="A39">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Jukema, Jw" sort="Jukema, Jw" uniqKey="Jukema J" first="Jw" last="Jukema">Jw Jukema</name><affiliation><nlm:aff id="A11">Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Dejager, Pl" sort="Dejager, Pl" uniqKey="Dejager P" first="Pl" last="Dejager">Pl Dejager</name><affiliation><nlm:aff id="A15">Program in Translational Neuropsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Harris, Tb" sort="Harris, Tb" uniqKey="Harris T" first="Tb" last="Harris">Tb Harris</name><affiliation><nlm:aff id="A41">Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Liewald, Dc" sort="Liewald, Dc" uniqKey="Liewald D" first="Dc" last="Liewald">Dc Liewald</name><affiliation><nlm:aff id="A10">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Department of Psychology, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Amin, N" sort="Amin, N" uniqKey="Amin N" first="N" last="Amin">N. Amin</name><affiliation><nlm:aff id="A1">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Coker, Lh" sort="Coker, Lh" uniqKey="Coker L" first="Lh" last="Coker">Lh Coker</name><affiliation><nlm:aff id="A43">Division of Public Health Sciences and Neurology, Wake Forest School of Medicine, Winston-Salem, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Stegle, O" sort="Stegle, O" uniqKey="Stegle O" first="O" last="Stegle">O. Stegle</name><affiliation><nlm:aff id="A44">Max Planck Institute for Developmental Biology, Max Planck Institute for Intelligent Systems, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Lopez, Ol" sort="Lopez, Ol" uniqKey="Lopez O" first="Ol" last="Lopez">Ol Lopez</name><affiliation><nlm:aff id="A45">Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Schmidt, R" sort="Schmidt, R" uniqKey="Schmidt R" first="R" last="Schmidt">R. Schmidt</name><affiliation><nlm:aff id="A19">Department of Neurology, Medical University and General Hospital of Graz, Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Teumer, A" sort="Teumer, A" uniqKey="Teumer A" first="A" last="Teumer">A. Teumer</name><affiliation><nlm:aff id="A46">Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Ford, I" sort="Ford, I" uniqKey="Ford I" first="I" last="Ford">I. Ford</name><affiliation><nlm:aff id="A47">Robertson Center for biostatistics, University of Glasgow, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Karbalai, N" sort="Karbalai, N" uniqKey="Karbalai N" first="N" last="Karbalai">N. Karbalai</name><affiliation><nlm:aff id="A14">RG Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Becker, Jt" sort="Becker, Jt" uniqKey="Becker J" first="Jt" last="Becker">Jt Becker</name><affiliation><nlm:aff id="A45">Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Jonsdottir, Mk" sort="Jonsdottir, Mk" uniqKey="Jonsdottir M" first="Mk" last="Jonsdottir">Mk Jonsdottir</name><affiliation><nlm:aff id="A50">Landspitali Hospital, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Au, R" sort="Au, R" uniqKey="Au R" first="R" last="Au">R. Au</name><affiliation><nlm:aff id="A4">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A37">The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Fehrmann, Rsn" sort="Fehrmann, Rsn" uniqKey="Fehrmann R" first="Rsn" last="Fehrmann">Rsn Fehrmann</name><affiliation><nlm:aff id="A25">Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Herms, S" sort="Herms, S" uniqKey="Herms S" first="S" last="Herms">S. Herms</name><affiliation><nlm:aff id="A23">Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Department of Genomics, Life and Brain Research Center, Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Nalls, M" sort="Nalls, M" uniqKey="Nalls M" first="M" last="Nalls">M. Nalls</name><affiliation><nlm:aff id="A51">Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Zhao, W" sort="Zhao, W" uniqKey="Zhao W" first="W" last="Zhao">W. Zhao</name><affiliation><nlm:aff id="A13">Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA</nlm:aff></affiliation></author><author><name sortKey="Turner, St" sort="Turner, St" uniqKey="Turner S" first="St" last="Turner">St Turner</name><affiliation><nlm:aff id="A52">Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Yaffe, K" sort="Yaffe, K" uniqKey="Yaffe K" first="K" last="Yaffe">K. Yaffe</name><affiliation><nlm:aff id="A53">Departments of Psychiatry, Neurology and Epidemiology, University of California, San Francisco and San Francisco VA Medical Center, San Francisco, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Lohman, K" sort="Lohman, K" uniqKey="Lohman K" first="K" last="Lohman">K. Lohman</name><affiliation><nlm:aff id="A16">Department of Epidemiology, Wake Forest School of Medicine, Winston-Salem, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Van Swieten, Jc" sort="Van Swieten, Jc" uniqKey="Van Swieten J" first="Jc" last="Van Swieten">Jc Van Swieten</name><affiliation><nlm:aff id="A2">Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kardia, Slr" sort="Kardia, Slr" uniqKey="Kardia S" first="Slr" last="Kardia">Slr Kardia</name><affiliation><nlm:aff id="A13">Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA</nlm:aff></affiliation></author><author><name sortKey="Knopman, Ds" sort="Knopman, Ds" uniqKey="Knopman D" first="Ds" last="Knopman">Ds Knopman</name><affiliation><nlm:aff id="A54">Department of Neurology, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Meeks, Wm" sort="Meeks, Wm" uniqKey="Meeks W" first="Wm" last="Meeks">Wm Meeks</name><affiliation><nlm:aff id="A55">Department of Medicine, Division of Geriatrics, University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff></affiliation></author><author><name sortKey="Heiss, G" sort="Heiss, G" uniqKey="Heiss G" first="G" last="Heiss">G. Heiss</name><affiliation><nlm:aff id="A56">Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Holliday, Eg" sort="Holliday, Eg" uniqKey="Holliday E" first="Eg" last="Holliday">Eg Holliday</name><affiliation><nlm:aff id="A35">Hunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Schofield, Pw" sort="Schofield, Pw" uniqKey="Schofield P" first="Pw" last="Schofield">Pw Schofield</name><affiliation><nlm:aff id="A57">School of Medicine and Public Health, Faculty of Health, University of Newcastle, Newcastle, SW, Australia</nlm:aff></affiliation></author><author><name sortKey="Tanaka, T" sort="Tanaka, T" uniqKey="Tanaka T" first="T" last="Tanaka">T. Tanaka</name><affiliation><nlm:aff id="A58">Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Stott, Dj" sort="Stott, Dj" uniqKey="Stott D" first="Dj" last="Stott">Dj Stott</name><affiliation><nlm:aff id="A59">Department of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Wang, J" sort="Wang, J" uniqKey="Wang J" first="J" last="Wang">J. Wang</name><affiliation><nlm:aff id="A38">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Ridker, P" sort="Ridker, P" uniqKey="Ridker P" first="P" last="Ridker">P. Ridker</name><affiliation><nlm:aff id="A34">Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Gow, Aj" sort="Gow, Aj" uniqKey="Gow A" first="Aj" last="Gow">Aj Gow</name><affiliation><nlm:aff id="A10">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Department of Psychology, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Pattie, A" sort="Pattie, A" uniqKey="Pattie A" first="A" last="Pattie">A. Pattie</name><affiliation><nlm:aff id="A10">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Starr, Jm" sort="Starr, Jm" uniqKey="Starr J" first="Jm" last="Starr">Jm Starr</name><affiliation><nlm:aff id="A10">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A60">Alzheimer Scotland Research Centre, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Hocking, Lj" sort="Hocking, Lj" uniqKey="Hocking L" first="Lj" last="Hocking">Lj Hocking</name><affiliation><nlm:aff id="A61">Division of Applied Medicine, University of Aberdeen, Aberdeen, UK</nlm:aff></affiliation></author><author><name sortKey="Armstrong, Nj" sort="Armstrong, Nj" uniqKey="Armstrong N" first="Nj" last="Armstrong">Nj Armstrong</name><affiliation><nlm:aff id="A30">Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A63">School of Mathematics & Statistics and Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Mclachlan, S" sort="Mclachlan, S" uniqKey="Mclachlan S" first="S" last="Mclachlan">S. Mclachlan</name><affiliation><nlm:aff id="A18">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Shulman, Jm" sort="Shulman, Jm" uniqKey="Shulman J" first="Jm" last="Shulman">Jm Shulman</name><affiliation><nlm:aff id="A64">Department of Neurology, Baylor College of Medicine, Houston, TX, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Department of Molecular and Human Genetics, The Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Pilling, Lc" sort="Pilling, Lc" uniqKey="Pilling L" first="Lc" last="Pilling">Lc Pilling</name><affiliation><nlm:aff id="A66">Epidemiology and Public Health Group, University of Exeter Medical School, Exeter, UK</nlm:aff></affiliation></author><author><name sortKey="Eiriksdottir, G" sort="Eiriksdottir, G" uniqKey="Eiriksdottir G" first="G" last="Eiriksdottir">G. Eiriksdottir</name><affiliation><nlm:aff id="A7">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation></author><author><name sortKey="Scott, Rj" sort="Scott, Rj" uniqKey="Scott R" first="Rj" last="Scott">Rj Scott</name><affiliation><nlm:aff id="A35">Hunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Kochan, Na" sort="Kochan, Na" uniqKey="Kochan N" first="Na" last="Kochan">Na Kochan</name><affiliation><nlm:aff id="A30">Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Neuropsychiatric Institute, The Prince of Wales Hospital, Sydney, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Palotie, A" sort="Palotie, A" uniqKey="Palotie A" first="A" last="Palotie">A. Palotie</name><affiliation><nlm:aff id="A68">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A69">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A70">Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Hsieh, Y C" sort="Hsieh, Y C" uniqKey="Hsieh Y" first="Y-C" last="Hsieh">Y-C Hsieh</name><affiliation><nlm:aff id="A71">School of Public Health, Taipei Medical University, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Jg" sort="Eriksson, Jg" uniqKey="Eriksson J" first="Jg" last="Eriksson">Jg Eriksson</name><affiliation><nlm:aff id="A27">Folkhälsan Research Centre, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A73">National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A74">Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A75">Vasa Central Hospital, Vasa, Finland</nlm:aff></affiliation></author><author><name sortKey="Penman, A" sort="Penman, A" uniqKey="Penman A" first="A" last="Penman">A. Penman</name><affiliation><nlm:aff id="A76">Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff></affiliation></author><author><name sortKey="Gottesman, Rf" sort="Gottesman, Rf" uniqKey="Gottesman R" first="Rf" last="Gottesman">Rf Gottesman</name><affiliation><nlm:aff id="A77">Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Oostra, Ba" sort="Oostra, Ba" uniqKey="Oostra B" first="Ba" last="Oostra">Ba Oostra</name><affiliation><nlm:aff id="A1">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Yu, L" sort="Yu, L" uniqKey="Yu L" first="L" last="Yu">L. Yu</name><affiliation><nlm:aff id="A78">Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Destefano, Al" sort="Destefano, Al" uniqKey="Destefano A" first="Al" last="Destefano">Al Destefano</name><affiliation><nlm:aff id="A4">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A37">The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Beiser, A" sort="Beiser, A" uniqKey="Beiser A" first="A" last="Beiser">A. Beiser</name><affiliation><nlm:aff id="A4">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A37">The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Garcia, M" sort="Garcia, M" uniqKey="Garcia M" first="M" last="Garcia">M. Garcia</name><affiliation><nlm:aff id="A41">Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Rotter, Ji" sort="Rotter, Ji" uniqKey="Rotter J" first="Ji" last="Rotter">Ji Rotter</name><affiliation><nlm:aff id="A79">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A80">Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A81">Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Nothen, Mm" sort="Nothen, Mm" uniqKey="Nothen M" first="Mm" last="Nöthen">Mm Nöthen</name><affiliation><nlm:aff id="A24">Department of Genomics, Life and Brain Research Center, Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A82">German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Hofman, A" sort="Hofman, A" uniqKey="Hofman A" first="A" last="Hofman">A. Hofman</name><affiliation><nlm:aff id="A39">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Slagboom, Pe" sort="Slagboom, Pe" uniqKey="Slagboom P" first="Pe" last="Slagboom">Pe Slagboom</name><affiliation><nlm:aff id="A83">Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Westendorp, Rgj" sort="Westendorp, Rgj" uniqKey="Westendorp R" first="Rgj" last="Westendorp">Rgj Westendorp</name><affiliation><nlm:aff id="A84">Leiden Academy of Vitality and Ageing, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Buckley, Bm" sort="Buckley, Bm" uniqKey="Buckley B" first="Bm" last="Buckley">Bm Buckley</name><affiliation><nlm:aff id="A85">Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland</nlm:aff></affiliation></author><author><name sortKey="Wolf, Pa" sort="Wolf, Pa" uniqKey="Wolf P" first="Pa" last="Wolf">Pa Wolf</name><affiliation><nlm:aff id="A4">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A37">The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Ag" sort="Uitterlinden, Ag" uniqKey="Uitterlinden A" first="Ag" last="Uitterlinden">Ag Uitterlinden</name><affiliation><nlm:aff id="A39">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A86">Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Psaty, Bm" sort="Psaty, Bm" uniqKey="Psaty B" first="Bm" last="Psaty">Bm Psaty</name><affiliation><nlm:aff id="A9">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A88">Department of Health Services, University of Washington, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A89">Group Health Research Institute, Group Health, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Grabe, Hj" sort="Grabe, Hj" uniqKey="Grabe H" first="Hj" last="Grabe">Hj Grabe</name><affiliation><nlm:aff id="A90">Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS-Hospital Stralsund, Stralsund, Germany</nlm:aff></affiliation></author><author><name sortKey="Bandinelli, S" sort="Bandinelli, S" uniqKey="Bandinelli S" first="S" last="Bandinelli">S. Bandinelli</name><affiliation><nlm:aff id="A91">Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Chasman, Di" sort="Chasman, Di" uniqKey="Chasman D" first="Di" last="Chasman">Di Chasman</name><affiliation><nlm:aff id="A34">Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Grodstein, F" sort="Grodstein, F" uniqKey="Grodstein F" first="F" last="Grodstein">F. Grodstein</name><affiliation><nlm:aff id="A32">Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="R Ikkonen, K" sort="R Ikkonen, K" uniqKey="R Ikkonen K" first="K" last="R Ikkönen">K. R Ikkönen</name><affiliation><nlm:aff id="A26">Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Lambert, J C" sort="Lambert, J C" uniqKey="Lambert J" first="J-C" last="Lambert">J-C Lambert</name><affiliation><nlm:aff id="A31">Inserm, U1167, Institut Pasteur de Lille, Université Lille-Nord de France, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Porteous, Dj" sort="Porteous, Dj" uniqKey="Porteous D" first="Dj" last="Porteous">Dj Porteous</name><affiliation><nlm:aff id="A92">Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Price, Jf" sort="Price, Jf" uniqKey="Price J" first="Jf" last="Price">Jf Price</name><affiliation><nlm:aff id="A18">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Sachdev, Ps" sort="Sachdev, Ps" uniqKey="Sachdev P" first="Ps" last="Sachdev">Ps Sachdev</name><affiliation><nlm:aff id="A30">Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Neuropsychiatric Institute, The Prince of Wales Hospital, Sydney, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Ferrucci, L" sort="Ferrucci, L" uniqKey="Ferrucci L" first="L" last="Ferrucci">L. Ferrucci</name><affiliation><nlm:aff id="A58">Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Attia, Jr" sort="Attia, Jr" uniqKey="Attia J" first="Jr" last="Attia">Jr Attia</name><affiliation><nlm:aff id="A35">Hunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Rudan, I" sort="Rudan, I" uniqKey="Rudan I" first="I" last="Rudan">I. Rudan</name><affiliation><nlm:aff id="A18">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Hayward, C" sort="Hayward, C" uniqKey="Hayward C" first="C" last="Hayward">C. Hayward</name><affiliation><nlm:aff id="A17">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Wright, Af" sort="Wright, Af" uniqKey="Wright A" first="Af" last="Wright">Af Wright</name><affiliation><nlm:aff id="A17">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Wilson, Jf" sort="Wilson, Jf" uniqKey="Wilson J" first="Jf" last="Wilson">Jf Wilson</name><affiliation><nlm:aff id="A18">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Cichon, S" sort="Cichon, S" uniqKey="Cichon S" first="S" last="Cichon">S. Cichon</name><affiliation><nlm:aff id="A23">Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Department of Genomics, Life and Brain Research Center, Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A93">Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany</nlm:aff></affiliation></author><author><name sortKey="Franke, L" sort="Franke, L" uniqKey="Franke L" first="L" last="Franke">L. Franke</name><affiliation><nlm:aff id="A25">Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Schmidt, H" sort="Schmidt, H" uniqKey="Schmidt H" first="H" last="Schmidt">H. Schmidt</name><affiliation><nlm:aff id="A19">Department of Neurology, Medical University and General Hospital of Graz, Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Ding, J" sort="Ding, J" uniqKey="Ding J" first="J" last="Ding">J. Ding</name><affiliation><nlm:aff id="A94">Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA</nlm:aff></affiliation></author><author><name sortKey="De Craen, Ajm" sort="De Craen, Ajm" uniqKey="De Craen A" first="Ajm" last="De Craen">Ajm De Craen</name><affiliation><nlm:aff id="A12">Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Fornage, M" sort="Fornage, M" uniqKey="Fornage M" first="M" last="Fornage">M. Fornage</name><affiliation><nlm:aff id="A95">Institute for Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Bennett, Da" sort="Bennett, Da" uniqKey="Bennett D" first="Da" last="Bennett">Da Bennett</name><affiliation><nlm:aff id="A78">Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Deary, Ij" sort="Deary, Ij" uniqKey="Deary I" first="Ij" last="Deary">Ij Deary</name><affiliation><nlm:aff id="A10">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Department of Psychology, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Ikram, Ma" sort="Ikram, Ma" uniqKey="Ikram M" first="Ma" last="Ikram">Ma Ikram</name><affiliation><nlm:aff id="A2">Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A96">Department of Radiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Launer, Lj" sort="Launer, Lj" uniqKey="Launer L" first="Lj" last="Launer">Lj Launer</name><affiliation><nlm:aff id="A41">Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Fitzpatrick, Al" sort="Fitzpatrick, Al" uniqKey="Fitzpatrick A" first="Al" last="Fitzpatrick">Al Fitzpatrick</name><affiliation><nlm:aff id="A87">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Seshadri, S" sort="Seshadri, S" uniqKey="Seshadri S" first="S" last="Seshadri">S. Seshadri</name><affiliation><nlm:aff id="A4">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A37">The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cm" sort="Van Duijn, Cm" uniqKey="Van Duijn C" first="Cm" last="Van Duijn">Cm Van Duijn</name><affiliation><nlm:aff id="A1">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Mosley, Th" sort="Mosley, Th" uniqKey="Mosley T" first="Th" last="Mosley">Th Mosley</name><affiliation><nlm:aff id="A97">Department of Medicine and Neurology, University of Mississippi Medical Center, Jackson, MS, USA.</nlm:aff></affiliation></author></analytic><series><title level="j">Molecular psychiatry</title><idno type="ISSN">1359-4184</idno><idno type="eISSN">1476-5578</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">To identify common variants contributing to normal variation in two specific
domains of cognitive functioning, we conducted a genome-wide association study (GWAS) of
executive functioning and information processing speed in non-demented older adults from
the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) consortium.
Neuropsychological testing was available for 5429–32 070 subjects of European
ancestry aged 45 years or older, free of dementia and clinical stroke at the time of
cognitive testing from 20 cohorts in the discovery phase. We analyzed performance on the
Trail Making Test parts A and B, the Letter Digit Substitution Test (LDST), the Digit
Symbol Substitution Task (DSST), semantic and phonemic fluency tests, and the Stroop Color
and Word Test. Replication was sought in 1311-21860 subjects from 20 independent cohorts.
A significant association was observed in the discovery cohorts for the single-nucleotide
polymorphism (SNP) rs17518584 (discovery <italic>P-value</italic> = 3.12 ×
10<sup>−8</sup>) and in the joint discovery and replication meta-analysis
(<italic>P-value</italic> = 3.28 × 10<sup>−9</sup> after adjustment for
age, gender and education) in an intron of the gene cell adhesion molecule 2
(<italic>CADM2</italic>) for performance on the LDST/DSST. Rs17518584 is located about
170 kb upstream of the transcription start site of the major transcript for the
<italic>CADM2</italic> gene, but is within an intron of a variant transcript that
includes an alternative first exon. The variant is associated with expression of
<italic>CADM2</italic> in the cingulate cortex (<italic>P-value</italic> = 4 ×
10<sup>−4</sup>). The protein encoded by <italic>CADM2</italic> is involved in
glutamate signaling (<italic>P-value</italic> = 7.22 × 10<sup>−15</sup>),
gamma-aminobutyric acid (GABA) transport (<italic>P-value</italic> = 1.36 ×
10<sup>−11</sup>) and neuron cell-cell adhesion (<italic>P-value</italic> = 1.48
× 10<sup>−13</sup>). Our findings suggest that genetic variation in the
<italic>CADM2</italic> gene is associated with individual differences in information
processing speed.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
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ref-type="aff" rid="A97">97</xref></contrib></contrib-group><aff id="A1"><label>1</label>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A2"><label>2</label>Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A3"><label>3</label>Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA</aff><aff id="A4"><label>4</label>Department of Neurology, Boston University School of Medicine, Boston, MA, USA</aff><aff id="A5"><label>5</label>Institut National de la Santé et de la Recherche Médicale (INSERM), U897, Epidemiology and Biostatistics, University of Bordeaux, Bordeaux, France</aff><aff id="A6"><label>6</label>Department of Neurology, Bordeaux University Hospital, Bordeaux, France</aff><aff id="A7"><label>7</label>Icelandic Heart Association, Kopavogur, Iceland</aff><aff id="A8"><label>8</label>Faculty of Medicine, University of Iceland, Reykjavik, Iceland</aff><aff id="A9"><label>9</label>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA</aff><aff id="A10"><label>10</label>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</aff><aff id="A11"><label>11</label>Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="A12"><label>12</label>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="A13"><label>13</label>Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA</aff><aff id="A14"><label>14</label>RG Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany</aff><aff id="A15"><label>15</label>Program in Translational Neuropsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA</aff><aff id="A16"><label>16</label>Department of Epidemiology, Wake Forest School of Medicine, Winston-Salem, NC, USA</aff><aff id="A17"><label>17</label>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</aff><aff id="A18"><label>18</label>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</aff><aff id="A19"><label>19</label>Department of Neurology, Medical University and General Hospital of Graz, Graz, Austria</aff><aff id="A20"><label>20</label>Department of Public Health, University of Split, Split, Croatia</aff><aff id="A21"><label>21</label>Department of Public Health and Primary Care, Trinity College Dublin, Dublin, Ireland</aff><aff id="A22"><label>22</label>Institute of Neuroscience and Medicine (INM -1), Research Center Juelich, Juelich, Germany</aff><aff id="A23"><label>23</label>Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland</aff><aff id="A24"><label>24</label>Department of Genomics, Life and Brain Research Center, Institute of Human Genetics, University of Bonn, Bonn, Germany</aff><aff id="A25"><label>25</label>Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A26"><label>26</label>Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland</aff><aff id="A27"><label>27</label>Folkhälsan Research Centre, Helsinki, Finland</aff><aff id="A28"><label>28</label>Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, UK</aff><aff id="A29"><label>29</label>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany</aff><aff id="A30"><label>30</label>Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia</aff><aff id="A31"><label>31</label>Inserm, U1167, Institut Pasteur de Lille, Université Lille-Nord de France, Lille, France</aff><aff id="A32"><label>32</label>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA</aff><aff id="A33"><label>33</label>Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH, Baltimore, MD, USA</aff><aff id="A34"><label>34</label>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA</aff><aff id="A35"><label>35</label>Hunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia</aff><aff id="A36"><label>36</label>Medical Research Institute, University of Dundee, Dundee, UK</aff><aff id="A37"><label>37</label>The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA</aff><aff id="A38"><label>38</label>Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</aff><aff id="A39"><label>39</label>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A40"><label>40</label>Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands</aff><aff id="A41"><label>41</label>Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA</aff><aff id="A42"><label>42</label>Department of Psychology, University of Edinburgh, Edinburgh, UK</aff><aff id="A43"><label>43</label>Division of Public Health Sciences and Neurology, Wake Forest School of Medicine, Winston-Salem, NC, USA</aff><aff id="A44"><label>44</label>Max Planck Institute for Developmental Biology, Max Planck Institute for Intelligent Systems, Tübingen, Germany</aff><aff id="A45"><label>45</label>Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA</aff><aff id="A46"><label>46</label>Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany</aff><aff id="A47"><label>47</label>Robertson Center for biostatistics, University of Glasgow, Glasgow, UK</aff><aff id="A48"><label>48</label>Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA</aff><aff id="A49"><label>49</label>Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA</aff><aff id="A50"><label>50</label>Landspitali Hospital, Reykjavik, Iceland</aff><aff id="A51"><label>51</label>Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA</aff><aff id="A52"><label>52</label>Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA</aff><aff id="A53"><label>53</label>Departments of Psychiatry, Neurology and Epidemiology, University of California, San Francisco and San Francisco VA Medical Center, San Francisco, CA, USA</aff><aff id="A54"><label>54</label>Department of Neurology, Mayo Clinic, Rochester, MN, USA</aff><aff id="A55"><label>55</label>Department of Medicine, Division of Geriatrics, University of Mississippi Medical Center, Jackson, MS, USA</aff><aff id="A56"><label>56</label>Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA</aff><aff id="A57"><label>57</label>School of Medicine and Public Health, Faculty of Health, University of Newcastle, Newcastle, SW, Australia</aff><aff id="A58"><label>58</label>Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA</aff><aff id="A59"><label>59</label>Department of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK</aff><aff id="A60"><label>60</label>Alzheimer Scotland Research Centre, Edinburgh, UK</aff><aff id="A61"><label>61</label>Division of Applied Medicine, University of Aberdeen, Aberdeen, UK</aff><aff id="A62"><label>62</label>Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia</aff><aff id="A63"><label>63</label>School of Mathematics & Statistics and Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia</aff><aff id="A64"><label>64</label>Department of Neurology, Baylor College of Medicine, Houston, TX, USA</aff><aff id="A65"><label>65</label>Department of Molecular and Human Genetics, The Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA</aff><aff id="A66"><label>66</label>Epidemiology and Public Health Group, University of Exeter Medical School, Exeter, UK</aff><aff id="A67"><label>67</label>Neuropsychiatric Institute, The Prince of Wales Hospital, Sydney, NSW, Australia</aff><aff id="A68"><label>68</label>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK</aff><aff id="A69"><label>69</label>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland</aff><aff id="A70"><label>70</label>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</aff><aff id="A71"><label>71</label>School of Public Health, Taipei Medical University, Taipei, Taiwan</aff><aff id="A72"><label>72</label>Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland</aff><aff id="A73"><label>73</label>National Institute for Health and Welfare, Helsinki, Finland</aff><aff id="A74"><label>74</label>Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland</aff><aff id="A75"><label>75</label>Vasa Central Hospital, Vasa, Finland</aff><aff id="A76"><label>76</label>Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MS, USA</aff><aff id="A77"><label>77</label>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA</aff><aff id="A78"><label>78</label>Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA</aff><aff id="A79"><label>79</label>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</aff><aff id="A80"><label>80</label>Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA</aff><aff id="A81"><label>81</label>Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA</aff><aff id="A82"><label>82</label>German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany</aff><aff id="A83"><label>83</label>Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="A84"><label>84</label>Leiden Academy of Vitality and Ageing, Leiden, The Netherlands</aff><aff id="A85"><label>85</label>Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland</aff><aff id="A86"><label>86</label>Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A87"><label>87</label>Department of Epidemiology, University of Washington, Seattle, WA, USA</aff><aff id="A88"><label>88</label>Department of Health Services, University of Washington, Seattle, WA, USA</aff><aff id="A89"><label>89</label>Group Health Research Institute, Group Health, Seattle, WA, USA</aff><aff id="A90"><label>90</label>Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS-Hospital Stralsund, Stralsund, Germany</aff><aff id="A91"><label>91</label>Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</aff><aff id="A92"><label>92</label>Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</aff><aff id="A93"><label>93</label>Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany</aff><aff id="A94"><label>94</label>Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA</aff><aff id="A95"><label>95</label>Institute for Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA</aff><aff id="A96"><label>96</label>Department of Radiology, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A97"><label>97</label>Department of Medicine and Neurology, University of Mississippi Medical Center, Jackson, MS, USA.</aff><author-notes><corresp id="CR1">Correspondence: Dr TH Mosley, Department of Medicine (Geriatrics),
University of Mississippi Medical Center, 2500 North State Street, Jackson, 39216-4505 MS,
USA. <email>tmosley@umc.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>11</day><month>1</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>14</day><month>4</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>2</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>2</month><year>2016</year></pub-date><volume>21</volume><issue>2</issue><fpage>189</fpage><lpage>197</lpage><pmc-comment>elocation-id from pubmed: 10.1038/mp.2015.37</pmc-comment>
<abstract><p id="P1">To identify common variants contributing to normal variation in two specific
domains of cognitive functioning, we conducted a genome-wide association study (GWAS) of
executive functioning and information processing speed in non-demented older adults from
the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) consortium.
Neuropsychological testing was available for 5429–32 070 subjects of European
ancestry aged 45 years or older, free of dementia and clinical stroke at the time of
cognitive testing from 20 cohorts in the discovery phase. We analyzed performance on the
Trail Making Test parts A and B, the Letter Digit Substitution Test (LDST), the Digit
Symbol Substitution Task (DSST), semantic and phonemic fluency tests, and the Stroop Color
and Word Test. Replication was sought in 1311-21860 subjects from 20 independent cohorts.
A significant association was observed in the discovery cohorts for the single-nucleotide
polymorphism (SNP) rs17518584 (discovery <italic>P-value</italic> = 3.12 ×
10<sup>−8</sup>) and in the joint discovery and replication meta-analysis
(<italic>P-value</italic> = 3.28 × 10<sup>−9</sup> after adjustment for
age, gender and education) in an intron of the gene cell adhesion molecule 2
(<italic>CADM2</italic>) for performance on the LDST/DSST. Rs17518584 is located about
170 kb upstream of the transcription start site of the major transcript for the
<italic>CADM2</italic> gene, but is within an intron of a variant transcript that
includes an alternative first exon. The variant is associated with expression of
<italic>CADM2</italic> in the cingulate cortex (<italic>P-value</italic> = 4 ×
10<sup>−4</sup>). The protein encoded by <italic>CADM2</italic> is involved in
glutamate signaling (<italic>P-value</italic> = 7.22 × 10<sup>−15</sup>),
gamma-aminobutyric acid (GABA) transport (<italic>P-value</italic> = 1.36 ×
10<sup>−11</sup>) and neuron cell-cell adhesion (<italic>P-value</italic> = 1.48
× 10<sup>−13</sup>). Our findings suggest that genetic variation in the
<italic>CADM2</italic> gene is associated with individual differences in information
processing speed.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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