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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Meta-analysis of 32 genome-wide linkage studies of schizophrenia</title><author><name sortKey="Ng, Mym" sort="Ng, Mym" uniqKey="Ng M" first="Mym" last="Ng">Mym Ng</name><affiliation><nlm:aff id="A1">King’s College London, Department of Medical and Molecular Genetics, London, UK</nlm:aff></affiliation></author><author><name sortKey="Levinson, Df" sort="Levinson, Df" uniqKey="Levinson D" first="Df" last="Levinson">Df Levinson</name><affiliation><nlm:aff id="A2">Department of Psychiatry, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Faraone, Sv" sort="Faraone, Sv" uniqKey="Faraone S" first="Sv" last="Faraone">Sv Faraone</name><affiliation><nlm:aff id="A3">Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Suarez, Bk" sort="Suarez, Bk" uniqKey="Suarez B" first="Bk" last="Suarez">Bk Suarez</name><affiliation><nlm:aff id="A4">Washington University in St Louis, St Louis, MO, USA</nlm:aff></affiliation></author><author><name sortKey="Delisi, Le" sort="Delisi, Le" uniqKey="Delisi L" first="Le" last="Delisi">Le Delisi</name><affiliation><nlm:aff id="A5">Department of Psychiatry, The New York University Langone Medical Center, New York, NY, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Arinami, T" sort="Arinami, T" uniqKey="Arinami T" first="T" last="Arinami">T. Arinami</name><affiliation><nlm:aff id="A7">Department of Medical Genetics, University of Tsukuba, Tsukuba, Japan</nlm:aff></affiliation></author><author><name sortKey="Riley, B" sort="Riley, B" uniqKey="Riley B" first="B" last="Riley">B. Riley</name><affiliation><nlm:aff id="A8">Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA</nlm:aff></affiliation></author><author><name sortKey="Paunio, T" sort="Paunio, T" uniqKey="Paunio T" first="T" last="Paunio">T. Paunio</name><affiliation><nlm:aff id="A9">National Public Health Institute, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Pulver, Ae" sort="Pulver, Ae" uniqKey="Pulver A" first="Ae" last="Pulver">Ae Pulver</name><affiliation><nlm:aff id="A11">Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Holmans, Pa" sort="Holmans, Pa" uniqKey="Holmans P" first="Pa" last="Holmans">Pa Holmans</name><affiliation><nlm:aff id="A13">Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK</nlm:aff></affiliation></author><author><name sortKey="Escamilla, M" sort="Escamilla, M" uniqKey="Escamilla M" first="M" last="Escamilla">M. Escamilla</name><affiliation><nlm:aff id="A14">University of Texas Health Science Center at San Antonio, San Antonio, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Wildenauer, Db" sort="Wildenauer, Db" uniqKey="Wildenauer D" first="Db" last="Wildenauer">Db Wildenauer</name><affiliation><nlm:aff id="A15">Center for Clinical Research in Neuropsychiatry, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA, Australia</nlm:aff></affiliation></author><author><name sortKey="Williams, Nm" sort="Williams, Nm" uniqKey="Williams N" first="Nm" last="Williams">Nm Williams</name><affiliation><nlm:aff id="A13">Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK</nlm:aff></affiliation></author><author><name sortKey="Laurent, C" sort="Laurent, C" uniqKey="Laurent C" first="C" last="Laurent">C. Laurent</name><affiliation><nlm:aff id="A16">Department of Child Psychiatry, Université Pierre et Marie Curie and Hôpital de la Pitiè-Salpêtrière, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Mowry, Bj" sort="Mowry, Bj" uniqKey="Mowry B" first="Bj" last="Mowry">Bj Mowry</name><affiliation><nlm:aff id="A17">Queensland Centre for Mental Health Research and University of Queensland, Brisbane, QLD, Australia</nlm:aff></affiliation></author><author><name sortKey="Brzustowicz, Lm" sort="Brzustowicz, Lm" uniqKey="Brzustowicz L" first="Lm" last="Brzustowicz">Lm Brzustowicz</name><affiliation><nlm:aff id="A18">Department of Genetics, Rutgers University, Piscataway, NJ, USA</nlm:aff></affiliation></author><author><name sortKey="Maziade, M" sort="Maziade, M" uniqKey="Maziade M" first="M" last="Maziade">M. Maziade</name><affiliation><nlm:aff id="A19">Department of Psychiatry, Laval University & Centre de recherche Université Laval Robert-Giffard, Québec, QC, Canada</nlm:aff></affiliation></author><author><name sortKey="Sklar, P" sort="Sklar, P" uniqKey="Sklar P" first="P" last="Sklar">P. Sklar</name><affiliation><nlm:aff id="A20">Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Garver, Dl" sort="Garver, Dl" uniqKey="Garver D" first="Dl" last="Garver">Dl Garver</name><affiliation><nlm:aff id="A21">VA Medical Center, Asheville, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Abecasis, Gr" sort="Abecasis, Gr" uniqKey="Abecasis G" first="Gr" last="Abecasis">Gr Abecasis</name><affiliation><nlm:aff id="A22">Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA</nlm:aff></affiliation></author><author><name sortKey="Lerer, B" sort="Lerer, B" uniqKey="Lerer B" first="B" last="Lerer">B. Lerer</name><affiliation><nlm:aff id="A23">Department of Psychiatry, Hadassah-Hebrew University Medical Center, Jerusalem, Israel</nlm:aff></affiliation></author><author><name sortKey="Fallin, Md" sort="Fallin, Md" uniqKey="Fallin M" first="Md" last="Fallin">Md Fallin</name><affiliation><nlm:aff id="A24">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Gurling, Hmd" sort="Gurling, Hmd" uniqKey="Gurling H" first="Hmd" last="Gurling">Hmd Gurling</name><affiliation><nlm:aff id="A25">Department of Mental Health Sciences, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Gejman, Pv" sort="Gejman, Pv" uniqKey="Gejman P" first="Pv" last="Gejman">Pv Gejman</name><affiliation><nlm:aff id="A26">Center for Psychiatric Genetics, NorthShore University HealthSystem Research Institute and Northwestern University, Evanston, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Lindholm, E" sort="Lindholm, E" uniqKey="Lindholm E" first="E" last="Lindholm">E. Lindholm</name><affiliation><nlm:aff id="A27">Department of Development & Genetics, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Moises, Hw" sort="Moises, Hw" uniqKey="Moises H" first="Hw" last="Moises">Hw Moises</name><affiliation><nlm:aff id="A28">University of Kiel, Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Byerley, W" sort="Byerley, W" uniqKey="Byerley W" first="W" last="Byerley">W. Byerley</name><affiliation><nlm:aff id="A29">University of California, San Francisco, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Wijsman, Em" sort="Wijsman, Em" uniqKey="Wijsman E" first="Em" last="Wijsman">Em Wijsman</name><affiliation><nlm:aff id="A30">Departments of Medicine and Biostatistics, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Forabosco, P" sort="Forabosco, P" uniqKey="Forabosco P" first="P" last="Forabosco">P. Forabosco</name><affiliation><nlm:aff id="A1">King’s College London, Department of Medical and Molecular Genetics, London, UK</nlm:aff></affiliation></author><author><name sortKey="Tsuang, Mt" sort="Tsuang, Mt" uniqKey="Tsuang M" first="Mt" last="Tsuang">Mt Tsuang</name><affiliation><nlm:aff id="A31">Center for Behavioral Genomics and Department of Psychiatry, University of California, San Diego, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Harvard Institute of Psychiatric Epidemiology & Genetics, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Hwu, H G" sort="Hwu, H G" uniqKey="Hwu H" first="H-G" last="Hwu">H-G Hwu</name><affiliation><nlm:aff id="A33">National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Okazaki, Y" sort="Okazaki, Y" uniqKey="Okazaki Y" first="Y" last="Okazaki">Y. Okazaki</name><affiliation><nlm:aff id="A34">Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Kendler, Ks" sort="Kendler, Ks" uniqKey="Kendler K" first="Ks" last="Kendler">Ks Kendler</name><affiliation><nlm:aff id="A8">Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA</nlm:aff></affiliation></author><author><name sortKey="Wormley, B" sort="Wormley, B" uniqKey="Wormley B" first="B" last="Wormley">B. Wormley</name><affiliation><nlm:aff id="A8">Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA</nlm:aff></affiliation></author><author><name sortKey="Fanous, A" sort="Fanous, A" uniqKey="Fanous A" first="A" last="Fanous">A. Fanous</name><affiliation><nlm:aff id="A35">Washington VA Medical Center, Washington, DC, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Department of Psychiatry, Georgetown University Medical Center, Virginia Commonwealth University, Richmond, VA, USA</nlm:aff></affiliation></author><author><name sortKey="Walsh, D" sort="Walsh, D" uniqKey="Walsh D" first="D" last="Walsh">D. Walsh</name><affiliation><nlm:aff id="A37">The Health Research Board, Dublin, Ireland</nlm:aff></affiliation></author><author><name sortKey="O Eill, Fa" sort="O Eill, Fa" uniqKey="O Eill F" first="Fa" last="O Eill">Fa O Eill</name><affiliation><nlm:aff id="A38">Department of Psychiatry, Queens University, Belfast, Northern Ireland</nlm:aff></affiliation></author><author><name sortKey="Peltonen, L" sort="Peltonen, L" uniqKey="Peltonen L" first="L" last="Peltonen">L. Peltonen</name><affiliation><nlm:aff id="A39">Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Department of Medical Genetics, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A41">The Broad Institute, MIT, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Nestadt, G" sort="Nestadt, G" uniqKey="Nestadt G" first="G" last="Nestadt">G. Nestadt</name><affiliation><nlm:aff id="A11">Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Lasseter, Vk" sort="Lasseter, Vk" uniqKey="Lasseter V" first="Vk" last="Lasseter">Vk Lasseter</name><affiliation><nlm:aff id="A11">Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Liang, Ky" sort="Liang, Ky" uniqKey="Liang K" first="Ky" last="Liang">Ky Liang</name><affiliation><nlm:aff id="A43">Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Papadimitriou, Gm" sort="Papadimitriou, Gm" uniqKey="Papadimitriou G" first="Gm" last="Papadimitriou">Gm Papadimitriou</name><affiliation><nlm:aff id="A44">1st Department of Psychiatry, University of Athens Medical School, and University Mental Health Research Institute, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Dikeos, Dg" sort="Dikeos, Dg" uniqKey="Dikeos D" first="Dg" last="Dikeos">Dg Dikeos</name><affiliation><nlm:aff id="A44">1st Department of Psychiatry, University of Athens Medical School, and University Mental Health Research Institute, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Schwab, Sg" sort="Schwab, Sg" uniqKey="Schwab S" first="Sg" last="Schwab">Sg Schwab</name><affiliation><nlm:aff id="A45">Western Australian Institute for Medical Research, University of Western Australia, Perth, WA, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A46">School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A47">School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia</nlm:aff></affiliation></author><author><name sortKey="Owen, Mj" sort="Owen, Mj" uniqKey="Owen M" first="Mj" last="Owen">Mj Owen</name><affiliation><nlm:aff id="A13">Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK</nlm:aff></affiliation></author><author><name sortKey="O Onovan, Mc" sort="O Onovan, Mc" uniqKey="O Onovan M" first="Mc" last="O Onovan">Mc O Onovan</name><affiliation><nlm:aff id="A13">Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK</nlm:aff></affiliation></author><author><name sortKey="Norton, N" sort="Norton, N" uniqKey="Norton N" first="N" last="Norton">N. Norton</name><affiliation><nlm:aff id="A13">Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK</nlm:aff></affiliation></author><author><name sortKey="Hare, E" sort="Hare, E" uniqKey="Hare E" first="E" last="Hare">E. Hare</name><affiliation><nlm:aff id="A14">University of Texas Health Science Center at San Antonio, San Antonio, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Raventos, H" sort="Raventos, H" uniqKey="Raventos H" first="H" last="Raventos">H. Raventos</name><affiliation><nlm:aff id="A48">School of Biology and CIBCM, University of Costa Rica, San Jose, Costa Rica</nlm:aff></affiliation></author><author><name sortKey="Nicolini, H" sort="Nicolini, H" uniqKey="Nicolini H" first="H" last="Nicolini">H. Nicolini</name><affiliation><nlm:aff id="A49">Carracci Medical Group and Universidad Autonoma de la Ciudad de Mexico, Mexico City, Mexico</nlm:aff></affiliation></author><author><name sortKey="Albus, M" sort="Albus, M" uniqKey="Albus M" first="M" last="Albus">M. Albus</name><affiliation><nlm:aff id="A50">State Mental Hospital, Haar, Germany</nlm:aff></affiliation></author><author><name sortKey="Maier, W" sort="Maier, W" uniqKey="Maier W" first="W" last="Maier">W. Maier</name><affiliation><nlm:aff id="A51">Department of Psychiatry, University of Bonn, Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Nimgaonkar, Vl" sort="Nimgaonkar, Vl" uniqKey="Nimgaonkar V" first="Vl" last="Nimgaonkar">Vl Nimgaonkar</name><affiliation><nlm:aff id="A52">Departments of Psychiatry and Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Terenius, L" sort="Terenius, L" uniqKey="Terenius L" first="L" last="Terenius">L. Terenius</name><affiliation><nlm:aff id="A53">Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Mallet, J" sort="Mallet, J" uniqKey="Mallet J" first="J" last="Mallet">J. Mallet</name><affiliation><nlm:aff id="A54">Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, Centre National de la Recherche Scientifique, Hôpital de la Pitié Salpêtrière, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Jay, M" sort="Jay, M" uniqKey="Jay M" first="M" last="Jay">M. Jay</name><affiliation><nlm:aff id="A55">Department of Child Psychiatry, Université Pierre et Marie Curie and Hôpital de la Pitiè-Salpêtrière, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Godard, S" sort="Godard, S" uniqKey="Godard S" first="S" last="Godard">S. Godard</name><affiliation><nlm:aff id="A56">INSERM, Institut de Myologie, Hôpital de la Pitiè-Salpêtrière, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Nertney, D" sort="Nertney, D" uniqKey="Nertney D" first="D" last="Nertney">D. Nertney</name><affiliation><nlm:aff id="A57">Queensland Centre for Mental Health Research and University of Queensland, Brisbane, QLD, Australia</nlm:aff></affiliation></author><author><name sortKey="Alexander, M" sort="Alexander, M" uniqKey="Alexander M" first="M" last="Alexander">M. Alexander</name><affiliation><nlm:aff id="A2">Department of Psychiatry, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Crowe, Rr" sort="Crowe, Rr" uniqKey="Crowe R" first="Rr" last="Crowe">Rr Crowe</name><affiliation><nlm:aff id="A58">Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, IA, USA</nlm:aff></affiliation></author><author><name sortKey="Silverman, Jm" sort="Silverman, Jm" uniqKey="Silverman J" first="Jm" last="Silverman">Jm Silverman</name><affiliation><nlm:aff id="A59">Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Bassett, As" sort="Bassett, As" uniqKey="Bassett A" first="As" last="Bassett">As Bassett</name><affiliation><nlm:aff id="A60">Clinical Genetics Research Program, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Roy, M A" sort="Roy, M A" uniqKey="Roy M" first="M-A" last="Roy">M-A Roy</name><affiliation><nlm:aff id="A19">Department of Psychiatry, Laval University & Centre de recherche Université Laval Robert-Giffard, Québec, QC, Canada</nlm:aff></affiliation></author><author><name sortKey="Merette, C" sort="Merette, C" uniqKey="Merette C" first="C" last="Mérette">C. Mérette</name><affiliation><nlm:aff id="A19">Department of Psychiatry, Laval University & Centre de recherche Université Laval Robert-Giffard, Québec, QC, Canada</nlm:aff></affiliation></author><author><name sortKey="Pato, Cn" sort="Pato, Cn" uniqKey="Pato C" first="Cn" last="Pato">Cn Pato</name><affiliation><nlm:aff id="A61">Center for Genomic Psychiatry, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Pato, Mt" sort="Pato, Mt" uniqKey="Pato M" first="Mt" last="Pato">Mt Pato</name><affiliation><nlm:aff id="A61">Center for Genomic Psychiatry, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Roos, J Louw" sort="Roos, J Louw" uniqKey="Roos J" first="J Louw" last="Roos">J Louw Roos</name><affiliation><nlm:aff id="A62">Department of Psychiatry, University of Pretoria, Weskoppies Hospital, Pretoria, Republic of South Africa</nlm:aff></affiliation></author><author><name sortKey="Kohn, Y" sort="Kohn, Y" uniqKey="Kohn Y" first="Y" last="Kohn">Y. Kohn</name><affiliation><nlm:aff id="A23">Department of Psychiatry, Hadassah-Hebrew University Medical Center, Jerusalem, Israel</nlm:aff></affiliation></author><author><name sortKey="Amann Zalcenstein, D" sort="Amann Zalcenstein, D" uniqKey="Amann Zalcenstein D" first="D" last="Amann-Zalcenstein">D. Amann-Zalcenstein</name><affiliation><nlm:aff id="A63">Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel</nlm:aff></affiliation></author><author><name sortKey="Kalsi, G" sort="Kalsi, G" uniqKey="Kalsi G" first="G" last="Kalsi">G. Kalsi</name><affiliation><nlm:aff id="A25">Department of Mental Health Sciences, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Mcquillin, A" sort="Mcquillin, A" uniqKey="Mcquillin A" first="A" last="Mcquillin">A. Mcquillin</name><affiliation><nlm:aff id="A25">Department of Mental Health Sciences, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Curtis, D" sort="Curtis, D" uniqKey="Curtis D" first="D" last="Curtis">D. Curtis</name><affiliation><nlm:aff id="A64">Department of Psychological Medicine, St Bartholomew’s and Royal London School of Medicine and Dentistry, London, UK</nlm:aff></affiliation></author><author><name sortKey="Brynjolfson, J" sort="Brynjolfson, J" uniqKey="Brynjolfson J" first="J" last="Brynjolfson">J. Brynjolfson</name><affiliation><nlm:aff id="A65">Department of Psychiatry, General Hospital, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Sigmundsson, T" sort="Sigmundsson, T" uniqKey="Sigmundsson T" first="T" last="Sigmundsson">T. Sigmundsson</name><affiliation><nlm:aff id="A65">Department of Psychiatry, General Hospital, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Petursson, H" sort="Petursson, H" uniqKey="Petursson H" first="H" last="Petursson">H. Petursson</name><affiliation><nlm:aff id="A65">Department of Psychiatry, General Hospital, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Sanders, Ar" sort="Sanders, Ar" uniqKey="Sanders A" first="Ar" last="Sanders">Ar Sanders</name><affiliation><nlm:aff id="A26">Center for Psychiatric Genetics, NorthShore University HealthSystem Research Institute and Northwestern University, Evanston, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Duan, J" sort="Duan, J" uniqKey="Duan J" first="J" last="Duan">J. Duan</name><affiliation><nlm:aff id="A26">Center for Psychiatric Genetics, NorthShore University HealthSystem Research Institute and Northwestern University, Evanston, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Jazin, E" sort="Jazin, E" uniqKey="Jazin E" first="E" last="Jazin">E. Jazin</name><affiliation><nlm:aff id="A27">Department of Development & Genetics, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Myles Worsley, M" sort="Myles Worsley, M" uniqKey="Myles Worsley M" first="M" last="Myles-Worsley">M. Myles-Worsley</name><affiliation><nlm:aff id="A66">Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Karayiorgou, M" sort="Karayiorgou, M" uniqKey="Karayiorgou M" first="M" last="Karayiorgou">M. Karayiorgou</name><affiliation><nlm:aff id="A67">Departments of Psychiatry and Genetics & Development, Columbia University Medical Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Lewis, Cm" sort="Lewis, Cm" uniqKey="Lewis C" first="Cm" last="Lewis">Cm Lewis</name><affiliation><nlm:aff id="A1">King’s College London, Department of Medical and Molecular Genetics, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A68">King’s College London, MRC SGDP Centre, Institute of Psychiatry, London, UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19349958</idno><idno type="pmc">2715392</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715392</idno><idno type="RBID">PMC:2715392</idno><idno type="doi">10.1038/mp.2008.135</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">002197</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002197</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Meta-analysis of 32 genome-wide linkage studies of schizophrenia</title><author><name sortKey="Ng, Mym" sort="Ng, Mym" uniqKey="Ng M" first="Mym" last="Ng">Mym Ng</name><affiliation><nlm:aff id="A1">King’s College London, Department of Medical and Molecular Genetics, London, UK</nlm:aff></affiliation></author><author><name sortKey="Levinson, Df" sort="Levinson, Df" uniqKey="Levinson D" first="Df" last="Levinson">Df Levinson</name><affiliation><nlm:aff id="A2">Department of Psychiatry, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Faraone, Sv" sort="Faraone, Sv" uniqKey="Faraone S" first="Sv" last="Faraone">Sv Faraone</name><affiliation><nlm:aff id="A3">Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Suarez, Bk" sort="Suarez, Bk" uniqKey="Suarez B" first="Bk" last="Suarez">Bk Suarez</name><affiliation><nlm:aff id="A4">Washington University in St Louis, St Louis, MO, USA</nlm:aff></affiliation></author><author><name sortKey="Delisi, Le" sort="Delisi, Le" uniqKey="Delisi L" first="Le" last="Delisi">Le Delisi</name><affiliation><nlm:aff id="A5">Department of Psychiatry, The New York University Langone Medical Center, New York, NY, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Arinami, T" sort="Arinami, T" uniqKey="Arinami T" first="T" last="Arinami">T. Arinami</name><affiliation><nlm:aff id="A7">Department of Medical Genetics, University of Tsukuba, Tsukuba, Japan</nlm:aff></affiliation></author><author><name sortKey="Riley, B" sort="Riley, B" uniqKey="Riley B" first="B" last="Riley">B. Riley</name><affiliation><nlm:aff id="A8">Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA</nlm:aff></affiliation></author><author><name sortKey="Paunio, T" sort="Paunio, T" uniqKey="Paunio T" first="T" last="Paunio">T. Paunio</name><affiliation><nlm:aff id="A9">National Public Health Institute, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Pulver, Ae" sort="Pulver, Ae" uniqKey="Pulver A" first="Ae" last="Pulver">Ae Pulver</name><affiliation><nlm:aff id="A11">Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Holmans, Pa" sort="Holmans, Pa" uniqKey="Holmans P" first="Pa" last="Holmans">Pa Holmans</name><affiliation><nlm:aff id="A13">Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK</nlm:aff></affiliation></author><author><name sortKey="Escamilla, M" sort="Escamilla, M" uniqKey="Escamilla M" first="M" last="Escamilla">M. Escamilla</name><affiliation><nlm:aff id="A14">University of Texas Health Science Center at San Antonio, San Antonio, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Wildenauer, Db" sort="Wildenauer, Db" uniqKey="Wildenauer D" first="Db" last="Wildenauer">Db Wildenauer</name><affiliation><nlm:aff id="A15">Center for Clinical Research in Neuropsychiatry, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA, Australia</nlm:aff></affiliation></author><author><name sortKey="Williams, Nm" sort="Williams, Nm" uniqKey="Williams N" first="Nm" last="Williams">Nm Williams</name><affiliation><nlm:aff id="A13">Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK</nlm:aff></affiliation></author><author><name sortKey="Laurent, C" sort="Laurent, C" uniqKey="Laurent C" first="C" last="Laurent">C. Laurent</name><affiliation><nlm:aff id="A16">Department of Child Psychiatry, Université Pierre et Marie Curie and Hôpital de la Pitiè-Salpêtrière, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Mowry, Bj" sort="Mowry, Bj" uniqKey="Mowry B" first="Bj" last="Mowry">Bj Mowry</name><affiliation><nlm:aff id="A17">Queensland Centre for Mental Health Research and University of Queensland, Brisbane, QLD, Australia</nlm:aff></affiliation></author><author><name sortKey="Brzustowicz, Lm" sort="Brzustowicz, Lm" uniqKey="Brzustowicz L" first="Lm" last="Brzustowicz">Lm Brzustowicz</name><affiliation><nlm:aff id="A18">Department of Genetics, Rutgers University, Piscataway, NJ, USA</nlm:aff></affiliation></author><author><name sortKey="Maziade, M" sort="Maziade, M" uniqKey="Maziade M" first="M" last="Maziade">M. Maziade</name><affiliation><nlm:aff id="A19">Department of Psychiatry, Laval University & Centre de recherche Université Laval Robert-Giffard, Québec, QC, Canada</nlm:aff></affiliation></author><author><name sortKey="Sklar, P" sort="Sklar, P" uniqKey="Sklar P" first="P" last="Sklar">P. Sklar</name><affiliation><nlm:aff id="A20">Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Garver, Dl" sort="Garver, Dl" uniqKey="Garver D" first="Dl" last="Garver">Dl Garver</name><affiliation><nlm:aff id="A21">VA Medical Center, Asheville, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Abecasis, Gr" sort="Abecasis, Gr" uniqKey="Abecasis G" first="Gr" last="Abecasis">Gr Abecasis</name><affiliation><nlm:aff id="A22">Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA</nlm:aff></affiliation></author><author><name sortKey="Lerer, B" sort="Lerer, B" uniqKey="Lerer B" first="B" last="Lerer">B. Lerer</name><affiliation><nlm:aff id="A23">Department of Psychiatry, Hadassah-Hebrew University Medical Center, Jerusalem, Israel</nlm:aff></affiliation></author><author><name sortKey="Fallin, Md" sort="Fallin, Md" uniqKey="Fallin M" first="Md" last="Fallin">Md Fallin</name><affiliation><nlm:aff id="A24">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Gurling, Hmd" sort="Gurling, Hmd" uniqKey="Gurling H" first="Hmd" last="Gurling">Hmd Gurling</name><affiliation><nlm:aff id="A25">Department of Mental Health Sciences, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Gejman, Pv" sort="Gejman, Pv" uniqKey="Gejman P" first="Pv" last="Gejman">Pv Gejman</name><affiliation><nlm:aff id="A26">Center for Psychiatric Genetics, NorthShore University HealthSystem Research Institute and Northwestern University, Evanston, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Lindholm, E" sort="Lindholm, E" uniqKey="Lindholm E" first="E" last="Lindholm">E. Lindholm</name><affiliation><nlm:aff id="A27">Department of Development & Genetics, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Moises, Hw" sort="Moises, Hw" uniqKey="Moises H" first="Hw" last="Moises">Hw Moises</name><affiliation><nlm:aff id="A28">University of Kiel, Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Byerley, W" sort="Byerley, W" uniqKey="Byerley W" first="W" last="Byerley">W. Byerley</name><affiliation><nlm:aff id="A29">University of California, San Francisco, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Wijsman, Em" sort="Wijsman, Em" uniqKey="Wijsman E" first="Em" last="Wijsman">Em Wijsman</name><affiliation><nlm:aff id="A30">Departments of Medicine and Biostatistics, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Forabosco, P" sort="Forabosco, P" uniqKey="Forabosco P" first="P" last="Forabosco">P. Forabosco</name><affiliation><nlm:aff id="A1">King’s College London, Department of Medical and Molecular Genetics, London, UK</nlm:aff></affiliation></author><author><name sortKey="Tsuang, Mt" sort="Tsuang, Mt" uniqKey="Tsuang M" first="Mt" last="Tsuang">Mt Tsuang</name><affiliation><nlm:aff id="A31">Center for Behavioral Genomics and Department of Psychiatry, University of California, San Diego, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Harvard Institute of Psychiatric Epidemiology & Genetics, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Hwu, H G" sort="Hwu, H G" uniqKey="Hwu H" first="H-G" last="Hwu">H-G Hwu</name><affiliation><nlm:aff id="A33">National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Okazaki, Y" sort="Okazaki, Y" uniqKey="Okazaki Y" first="Y" last="Okazaki">Y. Okazaki</name><affiliation><nlm:aff id="A34">Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Kendler, Ks" sort="Kendler, Ks" uniqKey="Kendler K" first="Ks" last="Kendler">Ks Kendler</name><affiliation><nlm:aff id="A8">Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA</nlm:aff></affiliation></author><author><name sortKey="Wormley, B" sort="Wormley, B" uniqKey="Wormley B" first="B" last="Wormley">B. Wormley</name><affiliation><nlm:aff id="A8">Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA</nlm:aff></affiliation></author><author><name sortKey="Fanous, A" sort="Fanous, A" uniqKey="Fanous A" first="A" last="Fanous">A. Fanous</name><affiliation><nlm:aff id="A35">Washington VA Medical Center, Washington, DC, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Department of Psychiatry, Georgetown University Medical Center, Virginia Commonwealth University, Richmond, VA, USA</nlm:aff></affiliation></author><author><name sortKey="Walsh, D" sort="Walsh, D" uniqKey="Walsh D" first="D" last="Walsh">D. Walsh</name><affiliation><nlm:aff id="A37">The Health Research Board, Dublin, Ireland</nlm:aff></affiliation></author><author><name sortKey="O Eill, Fa" sort="O Eill, Fa" uniqKey="O Eill F" first="Fa" last="O Eill">Fa O Eill</name><affiliation><nlm:aff id="A38">Department of Psychiatry, Queens University, Belfast, Northern Ireland</nlm:aff></affiliation></author><author><name sortKey="Peltonen, L" sort="Peltonen, L" uniqKey="Peltonen L" first="L" last="Peltonen">L. Peltonen</name><affiliation><nlm:aff id="A39">Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Department of Medical Genetics, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A41">The Broad Institute, MIT, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Nestadt, G" sort="Nestadt, G" uniqKey="Nestadt G" first="G" last="Nestadt">G. Nestadt</name><affiliation><nlm:aff id="A11">Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Lasseter, Vk" sort="Lasseter, Vk" uniqKey="Lasseter V" first="Vk" last="Lasseter">Vk Lasseter</name><affiliation><nlm:aff id="A11">Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Liang, Ky" sort="Liang, Ky" uniqKey="Liang K" first="Ky" last="Liang">Ky Liang</name><affiliation><nlm:aff id="A43">Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Papadimitriou, Gm" sort="Papadimitriou, Gm" uniqKey="Papadimitriou G" first="Gm" last="Papadimitriou">Gm Papadimitriou</name><affiliation><nlm:aff id="A44">1st Department of Psychiatry, University of Athens Medical School, and University Mental Health Research Institute, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Dikeos, Dg" sort="Dikeos, Dg" uniqKey="Dikeos D" first="Dg" last="Dikeos">Dg Dikeos</name><affiliation><nlm:aff id="A44">1st Department of Psychiatry, University of Athens Medical School, and University Mental Health Research Institute, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Schwab, Sg" sort="Schwab, Sg" uniqKey="Schwab S" first="Sg" last="Schwab">Sg Schwab</name><affiliation><nlm:aff id="A45">Western Australian Institute for Medical Research, University of Western Australia, Perth, WA, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A46">School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A47">School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia</nlm:aff></affiliation></author><author><name sortKey="Owen, Mj" sort="Owen, Mj" uniqKey="Owen M" first="Mj" last="Owen">Mj Owen</name><affiliation><nlm:aff id="A13">Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK</nlm:aff></affiliation></author><author><name sortKey="O Onovan, Mc" sort="O Onovan, Mc" uniqKey="O Onovan M" first="Mc" last="O Onovan">Mc O Onovan</name><affiliation><nlm:aff id="A13">Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK</nlm:aff></affiliation></author><author><name sortKey="Norton, N" sort="Norton, N" uniqKey="Norton N" first="N" last="Norton">N. Norton</name><affiliation><nlm:aff id="A13">Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK</nlm:aff></affiliation></author><author><name sortKey="Hare, E" sort="Hare, E" uniqKey="Hare E" first="E" last="Hare">E. Hare</name><affiliation><nlm:aff id="A14">University of Texas Health Science Center at San Antonio, San Antonio, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Raventos, H" sort="Raventos, H" uniqKey="Raventos H" first="H" last="Raventos">H. Raventos</name><affiliation><nlm:aff id="A48">School of Biology and CIBCM, University of Costa Rica, San Jose, Costa Rica</nlm:aff></affiliation></author><author><name sortKey="Nicolini, H" sort="Nicolini, H" uniqKey="Nicolini H" first="H" last="Nicolini">H. Nicolini</name><affiliation><nlm:aff id="A49">Carracci Medical Group and Universidad Autonoma de la Ciudad de Mexico, Mexico City, Mexico</nlm:aff></affiliation></author><author><name sortKey="Albus, M" sort="Albus, M" uniqKey="Albus M" first="M" last="Albus">M. Albus</name><affiliation><nlm:aff id="A50">State Mental Hospital, Haar, Germany</nlm:aff></affiliation></author><author><name sortKey="Maier, W" sort="Maier, W" uniqKey="Maier W" first="W" last="Maier">W. Maier</name><affiliation><nlm:aff id="A51">Department of Psychiatry, University of Bonn, Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Nimgaonkar, Vl" sort="Nimgaonkar, Vl" uniqKey="Nimgaonkar V" first="Vl" last="Nimgaonkar">Vl Nimgaonkar</name><affiliation><nlm:aff id="A52">Departments of Psychiatry and Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Terenius, L" sort="Terenius, L" uniqKey="Terenius L" first="L" last="Terenius">L. Terenius</name><affiliation><nlm:aff id="A53">Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Mallet, J" sort="Mallet, J" uniqKey="Mallet J" first="J" last="Mallet">J. Mallet</name><affiliation><nlm:aff id="A54">Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, Centre National de la Recherche Scientifique, Hôpital de la Pitié Salpêtrière, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Jay, M" sort="Jay, M" uniqKey="Jay M" first="M" last="Jay">M. Jay</name><affiliation><nlm:aff id="A55">Department of Child Psychiatry, Université Pierre et Marie Curie and Hôpital de la Pitiè-Salpêtrière, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Godard, S" sort="Godard, S" uniqKey="Godard S" first="S" last="Godard">S. Godard</name><affiliation><nlm:aff id="A56">INSERM, Institut de Myologie, Hôpital de la Pitiè-Salpêtrière, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Nertney, D" sort="Nertney, D" uniqKey="Nertney D" first="D" last="Nertney">D. Nertney</name><affiliation><nlm:aff id="A57">Queensland Centre for Mental Health Research and University of Queensland, Brisbane, QLD, Australia</nlm:aff></affiliation></author><author><name sortKey="Alexander, M" sort="Alexander, M" uniqKey="Alexander M" first="M" last="Alexander">M. Alexander</name><affiliation><nlm:aff id="A2">Department of Psychiatry, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Crowe, Rr" sort="Crowe, Rr" uniqKey="Crowe R" first="Rr" last="Crowe">Rr Crowe</name><affiliation><nlm:aff id="A58">Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, IA, USA</nlm:aff></affiliation></author><author><name sortKey="Silverman, Jm" sort="Silverman, Jm" uniqKey="Silverman J" first="Jm" last="Silverman">Jm Silverman</name><affiliation><nlm:aff id="A59">Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Bassett, As" sort="Bassett, As" uniqKey="Bassett A" first="As" last="Bassett">As Bassett</name><affiliation><nlm:aff id="A60">Clinical Genetics Research Program, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Roy, M A" sort="Roy, M A" uniqKey="Roy M" first="M-A" last="Roy">M-A Roy</name><affiliation><nlm:aff id="A19">Department of Psychiatry, Laval University & Centre de recherche Université Laval Robert-Giffard, Québec, QC, Canada</nlm:aff></affiliation></author><author><name sortKey="Merette, C" sort="Merette, C" uniqKey="Merette C" first="C" last="Mérette">C. Mérette</name><affiliation><nlm:aff id="A19">Department of Psychiatry, Laval University & Centre de recherche Université Laval Robert-Giffard, Québec, QC, Canada</nlm:aff></affiliation></author><author><name sortKey="Pato, Cn" sort="Pato, Cn" uniqKey="Pato C" first="Cn" last="Pato">Cn Pato</name><affiliation><nlm:aff id="A61">Center for Genomic Psychiatry, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Pato, Mt" sort="Pato, Mt" uniqKey="Pato M" first="Mt" last="Pato">Mt Pato</name><affiliation><nlm:aff id="A61">Center for Genomic Psychiatry, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Roos, J Louw" sort="Roos, J Louw" uniqKey="Roos J" first="J Louw" last="Roos">J Louw Roos</name><affiliation><nlm:aff id="A62">Department of Psychiatry, University of Pretoria, Weskoppies Hospital, Pretoria, Republic of South Africa</nlm:aff></affiliation></author><author><name sortKey="Kohn, Y" sort="Kohn, Y" uniqKey="Kohn Y" first="Y" last="Kohn">Y. Kohn</name><affiliation><nlm:aff id="A23">Department of Psychiatry, Hadassah-Hebrew University Medical Center, Jerusalem, Israel</nlm:aff></affiliation></author><author><name sortKey="Amann Zalcenstein, D" sort="Amann Zalcenstein, D" uniqKey="Amann Zalcenstein D" first="D" last="Amann-Zalcenstein">D. Amann-Zalcenstein</name><affiliation><nlm:aff id="A63">Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel</nlm:aff></affiliation></author><author><name sortKey="Kalsi, G" sort="Kalsi, G" uniqKey="Kalsi G" first="G" last="Kalsi">G. Kalsi</name><affiliation><nlm:aff id="A25">Department of Mental Health Sciences, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Mcquillin, A" sort="Mcquillin, A" uniqKey="Mcquillin A" first="A" last="Mcquillin">A. Mcquillin</name><affiliation><nlm:aff id="A25">Department of Mental Health Sciences, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Curtis, D" sort="Curtis, D" uniqKey="Curtis D" first="D" last="Curtis">D. Curtis</name><affiliation><nlm:aff id="A64">Department of Psychological Medicine, St Bartholomew’s and Royal London School of Medicine and Dentistry, London, UK</nlm:aff></affiliation></author><author><name sortKey="Brynjolfson, J" sort="Brynjolfson, J" uniqKey="Brynjolfson J" first="J" last="Brynjolfson">J. Brynjolfson</name><affiliation><nlm:aff id="A65">Department of Psychiatry, General Hospital, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Sigmundsson, T" sort="Sigmundsson, T" uniqKey="Sigmundsson T" first="T" last="Sigmundsson">T. Sigmundsson</name><affiliation><nlm:aff id="A65">Department of Psychiatry, General Hospital, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Petursson, H" sort="Petursson, H" uniqKey="Petursson H" first="H" last="Petursson">H. Petursson</name><affiliation><nlm:aff id="A65">Department of Psychiatry, General Hospital, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Sanders, Ar" sort="Sanders, Ar" uniqKey="Sanders A" first="Ar" last="Sanders">Ar Sanders</name><affiliation><nlm:aff id="A26">Center for Psychiatric Genetics, NorthShore University HealthSystem Research Institute and Northwestern University, Evanston, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Duan, J" sort="Duan, J" uniqKey="Duan J" first="J" last="Duan">J. Duan</name><affiliation><nlm:aff id="A26">Center for Psychiatric Genetics, NorthShore University HealthSystem Research Institute and Northwestern University, Evanston, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Jazin, E" sort="Jazin, E" uniqKey="Jazin E" first="E" last="Jazin">E. Jazin</name><affiliation><nlm:aff id="A27">Department of Development & Genetics, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Myles Worsley, M" sort="Myles Worsley, M" uniqKey="Myles Worsley M" first="M" last="Myles-Worsley">M. Myles-Worsley</name><affiliation><nlm:aff id="A66">Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Karayiorgou, M" sort="Karayiorgou, M" uniqKey="Karayiorgou M" first="M" last="Karayiorgou">M. Karayiorgou</name><affiliation><nlm:aff id="A67">Departments of Psychiatry and Genetics & Development, Columbia University Medical Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Lewis, Cm" sort="Lewis, Cm" uniqKey="Lewis C" first="Cm" last="Lewis">Cm Lewis</name><affiliation><nlm:aff id="A1">King’s College London, Department of Medical and Molecular Genetics, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A68">King’s College London, MRC SGDP Centre, Institute of Psychiatry, London, UK</nlm:aff></affiliation></author></analytic><series><title level="j">Molecular psychiatry</title><idno type="ISSN">1359-4184</idno><idno type="eISSN">1476-5578</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">A genome scan meta-analysis (GSMA) was carried out on 32 independent genome-wide linkage scan analyses that included 3255 pedigrees with 7413 genotyped cases affected with schizophrenia (SCZ) or related disorders. The primary GSMA divided the autosomes into 120 bins, rank-ordered the bins within each study according to the most positive linkage result in each bin, summed these ranks (weighted for study size) for each bin across studies and determined the empirical probability of a given summed rank (<italic>P</italic><sub>SR</sub>) by simulation. Suggestive evidence for linkage was observed in two single bins, on chromosomes 5q (142-168 Mb) and 2q (103-134 Mb). Genome-wide evidence for linkage was detected on chromosome 2q (119-152 Mb) when bin boundaries were shifted to the middle of the previous bins. The primary analysis met empirical criteria for ‘aggregate’ genome-wide significance, indicating that some or all of 10 bins are likely to contain loci linked to SCZ, including regions of chromosomes 1, 2q, 3q, 4q, 5q, 8p and 10q. In a secondary analysis of 22 studies of European-ancestry samples, suggestive evidence for linkage was observed on chromosome 8p (16-33 Mb). Although the newer genome-wide association methodology has greater power to detect weak associations to single common DNA sequence variants, linkage analysis can detect diverse genetic effects that segregate in families, including multiple rare variants within one locus or several weakly associated loci in the same region. Therefore, the regions supported by this meta-analysis deserve close attention in future studies.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9607835</journal-id><journal-id journal-id-type="pubmed-jr-id">20545</journal-id><journal-id journal-id-type="nlm-ta">Mol Psychiatry</journal-id><journal-id journal-id-type="iso-abbrev">Mol. Psychiatry</journal-id><journal-title-group><journal-title>Molecular psychiatry</journal-title></journal-title-group><issn pub-type="ppub">1359-4184</issn><issn pub-type="epub">1476-5578</issn></journal-meta><article-meta><article-id pub-id-type="pmid">19349958</article-id><article-id pub-id-type="pmc">2715392</article-id><article-id pub-id-type="doi">10.1038/mp.2008.135</article-id><article-id pub-id-type="manuscript">UKMS4952</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Meta-analysis of 32 genome-wide linkage studies of schizophrenia</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Ng</surname><given-names>MYM</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Levinson</surname><given-names>DF</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib 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contrib-type="author"><name><surname>Jazin</surname><given-names>E</given-names></name><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Myles-Worsley</surname><given-names>M</given-names></name><xref ref-type="aff" rid="A66">66</xref></contrib><contrib contrib-type="author"><name><surname>Karayiorgou</surname><given-names>M</given-names></name><xref ref-type="aff" rid="A67">67</xref></contrib><contrib contrib-type="author"><name><surname>Lewis</surname><given-names>CM</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A68">68</xref></contrib></contrib-group><aff id="A1"><label>1</label>King’s College London, Department of Medical and Molecular Genetics, London, UK</aff><aff id="A2"><label>2</label>Department of Psychiatry, Stanford University, Stanford, CA, USA</aff><aff id="A3"><label>3</label>Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA</aff><aff id="A4"><label>4</label>Washington University in St Louis, St Louis, MO, USA</aff><aff id="A5"><label>5</label>Department of Psychiatry, The New York University Langone Medical Center, New York, NY, USA</aff><aff id="A6"><label>6</label>Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY, USA</aff><aff id="A7"><label>7</label>Department of Medical Genetics, University of Tsukuba, Tsukuba, Japan</aff><aff id="A8"><label>8</label>Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA</aff><aff id="A9"><label>9</label>National Public Health Institute, Helsinki, Finland</aff><aff id="A10"><label>10</label>Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A11"><label>11</label>Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA</aff><aff id="A12"><label>12</label>Department of Psychiatry, University of Indonesia, Jakarta, Indonesia</aff><aff id="A13"><label>13</label>Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK</aff><aff id="A14"><label>14</label>University of Texas Health Science Center at San Antonio, San Antonio, TX, USA</aff><aff id="A15"><label>15</label>Center for Clinical Research in Neuropsychiatry, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA, Australia</aff><aff id="A16"><label>16</label>Department of Child Psychiatry, Université Pierre et Marie Curie and Hôpital de la Pitiè-Salpêtrière, Paris, France</aff><aff id="A17"><label>17</label>Queensland Centre for Mental Health Research and University of Queensland, Brisbane, QLD, Australia</aff><aff id="A18"><label>18</label>Department of Genetics, Rutgers University, Piscataway, NJ, USA</aff><aff id="A19"><label>19</label>Department of Psychiatry, Laval University & Centre de recherche Université Laval Robert-Giffard, Québec, QC, Canada</aff><aff id="A20"><label>20</label>Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA</aff><aff id="A21"><label>21</label>VA Medical Center, Asheville, NC, USA</aff><aff id="A22"><label>22</label>Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA</aff><aff id="A23"><label>23</label>Department of Psychiatry, Hadassah-Hebrew University Medical Center, Jerusalem, Israel</aff><aff id="A24"><label>24</label>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA</aff><aff id="A25"><label>25</label>Department of Mental Health Sciences, University College London, London, UK</aff><aff id="A26"><label>26</label>Center for Psychiatric Genetics, NorthShore University HealthSystem Research Institute and Northwestern University, Evanston, IL, USA</aff><aff id="A27"><label>27</label>Department of Development & Genetics, Uppsala University, Uppsala, Sweden</aff><aff id="A28"><label>28</label>University of Kiel, Kiel, Germany</aff><aff id="A29"><label>29</label>University of California, San Francisco, CA, USA</aff><aff id="A30"><label>30</label>Departments of Medicine and Biostatistics, University of Washington, Seattle, WA, USA</aff><aff id="A31"><label>31</label>Center for Behavioral Genomics and Department of Psychiatry, University of California, San Diego, CA, USA</aff><aff id="A32"><label>32</label>Harvard Institute of Psychiatric Epidemiology & Genetics, Boston, MA, USA</aff><aff id="A33"><label>33</label>National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan</aff><aff id="A34"><label>34</label>Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan</aff><aff id="A35"><label>35</label>Washington VA Medical Center, Washington, DC, USA</aff><aff id="A36"><label>36</label>Department of Psychiatry, Georgetown University Medical Center, Virginia Commonwealth University, Richmond, VA, USA</aff><aff id="A37"><label>37</label>The Health Research Board, Dublin, Ireland</aff><aff id="A38"><label>38</label>Department of Psychiatry, Queens University, Belfast, Northern Ireland</aff><aff id="A39"><label>39</label>Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland</aff><aff id="A40"><label>40</label>Department of Medical Genetics, University of Helsinki, Helsinki, Finland</aff><aff id="A41"><label>41</label>The Broad Institute, MIT, Boston, MA, USA</aff><aff id="A42"><label>42</label>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK</aff><aff id="A43"><label>43</label>Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA</aff><aff id="A44"><label>44</label>1st Department of Psychiatry, University of Athens Medical School, and University Mental Health Research Institute, Athens, Greece</aff><aff id="A45"><label>45</label>Western Australian Institute for Medical Research, University of Western Australia, Perth, WA, Australia</aff><aff id="A46"><label>46</label>School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA, Australia</aff><aff id="A47"><label>47</label>School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia</aff><aff id="A48"><label>48</label>School of Biology and CIBCM, University of Costa Rica, San Jose, Costa Rica</aff><aff id="A49"><label>49</label>Carracci Medical Group and Universidad Autonoma de la Ciudad de Mexico, Mexico City, Mexico</aff><aff id="A50"><label>50</label>State Mental Hospital, Haar, Germany</aff><aff id="A51"><label>51</label>Department of Psychiatry, University of Bonn, Bonn, Germany</aff><aff id="A52"><label>52</label>Departments of Psychiatry and Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA</aff><aff id="A53"><label>53</label>Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, Sweden</aff><aff id="A54"><label>54</label>Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, Centre National de la Recherche Scientifique, Hôpital de la Pitié Salpêtrière, Paris, France</aff><aff id="A55"><label>55</label>Department of Child Psychiatry, Université Pierre et Marie Curie and Hôpital de la Pitiè-Salpêtrière, Paris, France</aff><aff id="A56"><label>56</label>INSERM, Institut de Myologie, Hôpital de la Pitiè-Salpêtrière, Paris, France</aff><aff id="A57"><label>57</label>Queensland Centre for Mental Health Research and University of Queensland, Brisbane, QLD, Australia</aff><aff id="A58"><label>58</label>Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, IA, USA</aff><aff id="A59"><label>59</label>Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA</aff><aff id="A60"><label>60</label>Clinical Genetics Research Program, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, ON, Canada</aff><aff id="A61"><label>61</label>Center for Genomic Psychiatry, University of Southern California, Los Angeles, CA, USA</aff><aff id="A62"><label>62</label>Department of Psychiatry, University of Pretoria, Weskoppies Hospital, Pretoria, Republic of South Africa</aff><aff id="A63"><label>63</label>Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel</aff><aff id="A64"><label>64</label>Department of Psychological Medicine, St Bartholomew’s and Royal London School of Medicine and Dentistry, London, UK</aff><aff id="A65"><label>65</label>Department of Psychiatry, General Hospital, Reykjavik, Iceland</aff><aff id="A66"><label>66</label>Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, USA</aff><aff id="A67"><label>67</label>Departments of Psychiatry and Genetics & Development, Columbia University Medical Center, New York, NY, USA</aff><aff id="A68"><label>68</label>King’s College London, MRC SGDP Centre, Institute of Psychiatry, London, UK</aff><author-notes><corresp id="CR1">Correspondence: Dr CM Lewis, Department of Medical and Molecular Genetics, King’s College London, 8th Floor Tower Wing, Guy’s Hospital, Great Maze Pond, London SE1 9RT, UK. E-mail: <email>Cathryn.lewis@kcl.ac.uk</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>3</day><month>6</month><year>2009</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2008</year></pub-date><pub-date pub-type="ppub"><month>8</month><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>2</month><year>2010</year></pub-date><volume>14</volume><issue>8</issue><fpage>774</fpage><lpage>785</lpage><permissions><copyright-statement>© 2008 Nature Publishing Group All rights reserved</copyright-statement><copyright-year>2008</copyright-year></permissions><abstract><p id="P1">A genome scan meta-analysis (GSMA) was carried out on 32 independent genome-wide linkage scan analyses that included 3255 pedigrees with 7413 genotyped cases affected with schizophrenia (SCZ) or related disorders. The primary GSMA divided the autosomes into 120 bins, rank-ordered the bins within each study according to the most positive linkage result in each bin, summed these ranks (weighted for study size) for each bin across studies and determined the empirical probability of a given summed rank (<italic>P</italic><sub>SR</sub>) by simulation. Suggestive evidence for linkage was observed in two single bins, on chromosomes 5q (142-168 Mb) and 2q (103-134 Mb). Genome-wide evidence for linkage was detected on chromosome 2q (119-152 Mb) when bin boundaries were shifted to the middle of the previous bins. The primary analysis met empirical criteria for ‘aggregate’ genome-wide significance, indicating that some or all of 10 bins are likely to contain loci linked to SCZ, including regions of chromosomes 1, 2q, 3q, 4q, 5q, 8p and 10q. In a secondary analysis of 22 studies of European-ancestry samples, suggestive evidence for linkage was observed on chromosome 8p (16-33 Mb). Although the newer genome-wide association methodology has greater power to detect weak associations to single common DNA sequence variants, linkage analysis can detect diverse genetic effects that segregate in families, including multiple rare variants within one locus or several weakly associated loci in the same region. Therefore, the regions supported by this meta-analysis deserve close attention in future studies.</p></abstract><kwd-group><kwd>genome</kwd><kwd>human</kwd><kwd>humans</kwd><kwd>schizophrenia/genetics</kwd><kwd>genetic predisposition to disease</kwd><kwd>linkage (genetics)</kwd><kwd>meta-analysis</kwd></kwd-group><funding-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>089061 || WT</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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