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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparison of Outcomes of Allogeneic Transplantation for CML with Cyclophosphamide in Combination with Intravenous Busulfan, Oral Busulfan or TBI</title><author><name sortKey="Copelan, Edward A" sort="Copelan, Edward A" uniqKey="Copelan E" first="Edward A." last="Copelan">Edward A. Copelan</name><affiliation><nlm:aff id="A1">Levine Cancer Institute, Carolinas Healthcare System, Charlotte, NC</nlm:aff></affiliation></author><author><name sortKey="Avalos, Belinda" sort="Avalos, Belinda" uniqKey="Avalos B" first="Belinda" last="Avalos">Belinda Avalos</name><affiliation><nlm:aff id="A1">Levine Cancer Institute, Carolinas Healthcare System, Charlotte, NC</nlm:aff></affiliation></author><author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name><affiliation><nlm:aff id="A2">Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Zhu, Xiaochun" sort="Zhu, Xiaochun" uniqKey="Zhu X" first="Xiaochun" last="Zhu">Xiaochun Zhu</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name><affiliation><nlm:aff id="A4">Hematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College of London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Grunwald, Michael R" sort="Grunwald, Michael R" uniqKey="Grunwald M" first="Michael R." last="Grunwald">Michael R. Grunwald</name><affiliation><nlm:aff id="A1">Levine Cancer Institute, Carolinas Healthcare System, Charlotte, NC</nlm:aff></affiliation></author><author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Hamilton, Betty K" sort="Hamilton, Betty K" uniqKey="Hamilton B" first="Betty K." last="Hamilton">Betty K. Hamilton</name><affiliation><nlm:aff id="A5">Department of Hematology and Oncology, Cleveland Clinic, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Hale, Gregory A" sort="Hale, Gregory A" uniqKey="Hale G" first="Gregory A." last="Hale">Gregory A. Hale</name><affiliation><nlm:aff id="A6">Department of Hematology/Oncology, All Children’s Hospital, St. Petersburg, FL</nlm:aff></affiliation></author><author><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I." last="Marks">David I. Marks</name><affiliation><nlm:aff id="A7">University Hospitals Bristol NHS Trust, Bristol, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Waller, Edmund K" sort="Waller, Edmund K" uniqKey="Waller E" first="Edmund K." last="Waller">Edmund K. Waller</name><affiliation><nlm:aff id="A8">Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA</nlm:aff></affiliation></author><author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name><affiliation><nlm:aff id="A9">Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Costa, Luciano J" sort="Costa, Luciano J" uniqKey="Costa L" first="Luciano J." last="Costa">Luciano J. Costa</name><affiliation><nlm:aff id="A10">Division of Hematology/Oncology, Department of Medicine, Medical University of South Carolina, Charleston, SC</nlm:aff></affiliation></author><author><name sortKey="Ramanathan, Muthalagu" sort="Ramanathan, Muthalagu" uniqKey="Ramanathan M" first="Muthalagu" last="Ramanathan">Muthalagu Ramanathan</name><affiliation><nlm:aff id="A11">UMass Memorial Medical Center, Worcester, MA</nlm:aff></affiliation></author><author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name><affiliation><nlm:aff id="A12">Department of Hematology, University Hospital, Grenoble, France</nlm:aff></affiliation></author><author><name sortKey="Khoury, H Jean" sort="Khoury, H Jean" uniqKey="Khoury H" first="H. Jean" last="Khoury">H. Jean Khoury</name><affiliation><nlm:aff id="A8">Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA</nlm:aff></affiliation></author><author><name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J." last="Weisdorf">Daniel J. Weisdorf</name><affiliation><nlm:aff id="A13">Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff></affiliation></author><author><name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name><affiliation><nlm:aff id="A14">Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff></affiliation></author><author><name sortKey="Kamble, Rammurti T" sort="Kamble, Rammurti T" uniqKey="Kamble R" first="Rammurti T." last="Kamble">Rammurti T. Kamble</name><affiliation><nlm:aff id="A15">Division of Hematology and Oncology, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX</nlm:aff></affiliation></author><author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name><affiliation><nlm:aff id="A16">Divison of Hematology, Academische Ziekenhuis Maastricht, Maastricht, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name><affiliation><nlm:aff id="A17">Department of Internal Medicine, Stony Brook University Medical Center, Stony Brook, NY</nlm:aff></affiliation></author><author><name sortKey="Litzow, Mark R" sort="Litzow, Mark R" uniqKey="Litzow M" first="Mark R." last="Litzow">Mark R. Litzow</name><affiliation><nlm:aff id="A18">Mayo Clinic, Rochester, MN</nlm:aff></affiliation></author><author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name><affiliation><nlm:aff id="A19">Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Van Besien, Koen W" sort="Van Besien, Koen W" uniqKey="Van Besien K" first="Koen W." last="Van Besien">Koen W. Van Besien</name><affiliation><nlm:aff id="A20">Department of Medical Oncology, Weill Cornell Medical College, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Ustun, Celalettin" sort="Ustun, Celalettin" uniqKey="Ustun C" first="Celalettin" last="Ustun">Celalettin Ustun</name><affiliation><nlm:aff id="A13">Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff></affiliation></author><author><name sortKey="Bolwell, Brian J" sort="Bolwell, Brian J" uniqKey="Bolwell B" first="Brian J." last="Bolwell">Brian J. Bolwell</name><affiliation><nlm:aff id="A5">Department of Hematology and Oncology, Cleveland Clinic, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Bredeson, Christopher N" sort="Bredeson, Christopher N" uniqKey="Bredeson C" first="Christopher N." last="Bredeson">Christopher N. Bredeson</name><affiliation><nlm:aff id="A21">The Ottawa Hospital Blood & Marrow Transplant Program and the Ottawa Hospital Research Institute, Ottawa, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Fasan, Omotayo" sort="Fasan, Omotayo" uniqKey="Fasan O" first="Omotayo" last="Fasan">Omotayo Fasan</name><affiliation><nlm:aff id="A1">Levine Cancer Institute, Carolinas Healthcare System, Charlotte, NC</nlm:aff></affiliation></author><author><name sortKey="Ghosh, Nilanjan" sort="Ghosh, Nilanjan" uniqKey="Ghosh N" first="Nilanjan" last="Ghosh">Nilanjan Ghosh</name><affiliation><nlm:aff id="A1">Levine Cancer Institute, Carolinas Healthcare System, Charlotte, NC</nlm:aff></affiliation></author><author><name sortKey="Horowitz, Mary M" sort="Horowitz, Mary M" uniqKey="Horowitz M" first="Mary M." last="Horowitz">Mary M. Horowitz</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Arora, Mukta" sort="Arora, Mukta" uniqKey="Arora M" first="Mukta" last="Arora">Mukta Arora</name><affiliation><nlm:aff id="A13">Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff></affiliation></author><author><name sortKey="Szer, Jeffrey" sort="Szer, Jeffrey" uniqKey="Szer J" first="Jeffrey" last="Szer">Jeffrey Szer</name><affiliation><nlm:aff id="A22">Department of Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Loren, Alison W" sort="Loren, Alison W" uniqKey="Loren A" first="Alison W." last="Loren">Alison W. Loren</name><affiliation><nlm:aff id="A23">Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</nlm:aff></affiliation></author><author><name sortKey="Alyea, Edwin P" sort="Alyea, Edwin P" uniqKey="Alyea E" first="Edwin P." last="Alyea">Edwin P. Alyea</name><affiliation><nlm:aff id="A24">Center of Hematologic Oncology, Dana-Farber Cancer Institute, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Cortes, Jorge" sort="Cortes, Jorge" uniqKey="Cortes J" first="Jorge" last="Cortes">Jorge Cortes</name><affiliation><nlm:aff id="A25">Department of Leukemia, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX</nlm:aff></affiliation></author><author><name sortKey="Maziarz, Richard T" sort="Maziarz, Richard T" uniqKey="Maziarz R" first="Richard T." last="Maziarz">Richard T. Maziarz</name><affiliation><nlm:aff id="A26">Center for Hematologic Malignancies, Oregon Health and Science University, Portland, OR</nlm:aff></affiliation></author><author><name sortKey="Kalaycio, Matt E" sort="Kalaycio, Matt E" uniqKey="Kalaycio M" first="Matt E." last="Kalaycio">Matt E. Kalaycio</name><affiliation><nlm:aff id="A5">Department of Hematology and Oncology, Cleveland Clinic, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25528388</idno><idno type="pmc">4329042</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329042</idno><idno type="RBID">PMC:4329042</idno><idno type="doi">10.1016/j.bbmt.2014.12.010</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002190</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002190</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparison of Outcomes of Allogeneic Transplantation for CML with Cyclophosphamide in Combination with Intravenous Busulfan, Oral Busulfan or TBI</title><author><name sortKey="Copelan, Edward A" sort="Copelan, Edward A" uniqKey="Copelan E" first="Edward A." last="Copelan">Edward A. Copelan</name><affiliation><nlm:aff id="A1">Levine Cancer Institute, Carolinas Healthcare System, Charlotte, NC</nlm:aff></affiliation></author><author><name sortKey="Avalos, Belinda" sort="Avalos, Belinda" uniqKey="Avalos B" first="Belinda" last="Avalos">Belinda Avalos</name><affiliation><nlm:aff id="A1">Levine Cancer Institute, Carolinas Healthcare System, Charlotte, NC</nlm:aff></affiliation></author><author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name><affiliation><nlm:aff id="A2">Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Zhu, Xiaochun" sort="Zhu, Xiaochun" uniqKey="Zhu X" first="Xiaochun" last="Zhu">Xiaochun Zhu</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name><affiliation><nlm:aff id="A4">Hematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College of London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Grunwald, Michael R" sort="Grunwald, Michael R" uniqKey="Grunwald M" first="Michael R." last="Grunwald">Michael R. Grunwald</name><affiliation><nlm:aff id="A1">Levine Cancer Institute, Carolinas Healthcare System, Charlotte, NC</nlm:aff></affiliation></author><author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Hamilton, Betty K" sort="Hamilton, Betty K" uniqKey="Hamilton B" first="Betty K." last="Hamilton">Betty K. Hamilton</name><affiliation><nlm:aff id="A5">Department of Hematology and Oncology, Cleveland Clinic, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Hale, Gregory A" sort="Hale, Gregory A" uniqKey="Hale G" first="Gregory A." last="Hale">Gregory A. Hale</name><affiliation><nlm:aff id="A6">Department of Hematology/Oncology, All Children’s Hospital, St. Petersburg, FL</nlm:aff></affiliation></author><author><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I." last="Marks">David I. Marks</name><affiliation><nlm:aff id="A7">University Hospitals Bristol NHS Trust, Bristol, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Waller, Edmund K" sort="Waller, Edmund K" uniqKey="Waller E" first="Edmund K." last="Waller">Edmund K. Waller</name><affiliation><nlm:aff id="A8">Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA</nlm:aff></affiliation></author><author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name><affiliation><nlm:aff id="A9">Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Costa, Luciano J" sort="Costa, Luciano J" uniqKey="Costa L" first="Luciano J." last="Costa">Luciano J. Costa</name><affiliation><nlm:aff id="A10">Division of Hematology/Oncology, Department of Medicine, Medical University of South Carolina, Charleston, SC</nlm:aff></affiliation></author><author><name sortKey="Ramanathan, Muthalagu" sort="Ramanathan, Muthalagu" uniqKey="Ramanathan M" first="Muthalagu" last="Ramanathan">Muthalagu Ramanathan</name><affiliation><nlm:aff id="A11">UMass Memorial Medical Center, Worcester, MA</nlm:aff></affiliation></author><author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name><affiliation><nlm:aff id="A12">Department of Hematology, University Hospital, Grenoble, France</nlm:aff></affiliation></author><author><name sortKey="Khoury, H Jean" sort="Khoury, H Jean" uniqKey="Khoury H" first="H. Jean" last="Khoury">H. Jean Khoury</name><affiliation><nlm:aff id="A8">Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA</nlm:aff></affiliation></author><author><name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J." last="Weisdorf">Daniel J. Weisdorf</name><affiliation><nlm:aff id="A13">Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff></affiliation></author><author><name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name><affiliation><nlm:aff id="A14">Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff></affiliation></author><author><name sortKey="Kamble, Rammurti T" sort="Kamble, Rammurti T" uniqKey="Kamble R" first="Rammurti T." last="Kamble">Rammurti T. Kamble</name><affiliation><nlm:aff id="A15">Division of Hematology and Oncology, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX</nlm:aff></affiliation></author><author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name><affiliation><nlm:aff id="A16">Divison of Hematology, Academische Ziekenhuis Maastricht, Maastricht, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name><affiliation><nlm:aff id="A17">Department of Internal Medicine, Stony Brook University Medical Center, Stony Brook, NY</nlm:aff></affiliation></author><author><name sortKey="Litzow, Mark R" sort="Litzow, Mark R" uniqKey="Litzow M" first="Mark R." last="Litzow">Mark R. Litzow</name><affiliation><nlm:aff id="A18">Mayo Clinic, Rochester, MN</nlm:aff></affiliation></author><author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name><affiliation><nlm:aff id="A19">Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Van Besien, Koen W" sort="Van Besien, Koen W" uniqKey="Van Besien K" first="Koen W." last="Van Besien">Koen W. Van Besien</name><affiliation><nlm:aff id="A20">Department of Medical Oncology, Weill Cornell Medical College, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Ustun, Celalettin" sort="Ustun, Celalettin" uniqKey="Ustun C" first="Celalettin" last="Ustun">Celalettin Ustun</name><affiliation><nlm:aff id="A13">Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff></affiliation></author><author><name sortKey="Bolwell, Brian J" sort="Bolwell, Brian J" uniqKey="Bolwell B" first="Brian J." last="Bolwell">Brian J. Bolwell</name><affiliation><nlm:aff id="A5">Department of Hematology and Oncology, Cleveland Clinic, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Bredeson, Christopher N" sort="Bredeson, Christopher N" uniqKey="Bredeson C" first="Christopher N." last="Bredeson">Christopher N. Bredeson</name><affiliation><nlm:aff id="A21">The Ottawa Hospital Blood & Marrow Transplant Program and the Ottawa Hospital Research Institute, Ottawa, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Fasan, Omotayo" sort="Fasan, Omotayo" uniqKey="Fasan O" first="Omotayo" last="Fasan">Omotayo Fasan</name><affiliation><nlm:aff id="A1">Levine Cancer Institute, Carolinas Healthcare System, Charlotte, NC</nlm:aff></affiliation></author><author><name sortKey="Ghosh, Nilanjan" sort="Ghosh, Nilanjan" uniqKey="Ghosh N" first="Nilanjan" last="Ghosh">Nilanjan Ghosh</name><affiliation><nlm:aff id="A1">Levine Cancer Institute, Carolinas Healthcare System, Charlotte, NC</nlm:aff></affiliation></author><author><name sortKey="Horowitz, Mary M" sort="Horowitz, Mary M" uniqKey="Horowitz M" first="Mary M." last="Horowitz">Mary M. Horowitz</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Arora, Mukta" sort="Arora, Mukta" uniqKey="Arora M" first="Mukta" last="Arora">Mukta Arora</name><affiliation><nlm:aff id="A13">Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff></affiliation></author><author><name sortKey="Szer, Jeffrey" sort="Szer, Jeffrey" uniqKey="Szer J" first="Jeffrey" last="Szer">Jeffrey Szer</name><affiliation><nlm:aff id="A22">Department of Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Loren, Alison W" sort="Loren, Alison W" uniqKey="Loren A" first="Alison W." last="Loren">Alison W. Loren</name><affiliation><nlm:aff id="A23">Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</nlm:aff></affiliation></author><author><name sortKey="Alyea, Edwin P" sort="Alyea, Edwin P" uniqKey="Alyea E" first="Edwin P." last="Alyea">Edwin P. Alyea</name><affiliation><nlm:aff id="A24">Center of Hematologic Oncology, Dana-Farber Cancer Institute, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Cortes, Jorge" sort="Cortes, Jorge" uniqKey="Cortes J" first="Jorge" last="Cortes">Jorge Cortes</name><affiliation><nlm:aff id="A25">Department of Leukemia, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX</nlm:aff></affiliation></author><author><name sortKey="Maziarz, Richard T" sort="Maziarz, Richard T" uniqKey="Maziarz R" first="Richard T." last="Maziarz">Richard T. Maziarz</name><affiliation><nlm:aff id="A26">Center for Hematologic Malignancies, Oregon Health and Science University, Portland, OR</nlm:aff></affiliation></author><author><name sortKey="Kalaycio, Matt E" sort="Kalaycio, Matt E" uniqKey="Kalaycio M" first="Matt E." last="Kalaycio">Matt E. Kalaycio</name><affiliation><nlm:aff id="A5">Department of Hematology and Oncology, Cleveland Clinic, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author></analytic><series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title><idno type="ISSN">1083-8791</idno><idno type="eISSN">1523-6536</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Cyclophosphamide in combination with busulfan (Bu) or total body irradiation (TBI) are the most commonly used myeloablative conditioning regimens in patients with Chronic Myeloid Leukemia (CML). We used data from the Center for International Bone Marrow Transplantation Research to compare outcomes in adults who underwent hematopoietic cell transplantation for CML in first chronic phase following myeloablative conditioning with cyclophosphamide (Cy) in combination with TBI, oral Bu or intravenous (IV) Bu. Four hundred thirty-eight adults received human leukocyte antigen (HLA)-matched sibling grafts and 235 received well-matched grafts from unrelated donors from 2000 through 2006. Important differences existed between the groups in distribution of donor relation, exposure to tyrosine kinase inhibitors and year of transplantation. In multivariate analysis, relapse occurred less frequently among patients receiving IV Bu compared to TBI (RR=0.36; P=0.022) or oral Bu (RR=0.39; P=0.028), but non-relapse mortality and survival were similar. A significant interaction was detected between donor relation and the main effect in leukemia-free survival (LFS). Among recipients of HLA-identical sibling grafts, but not URD grafts, LFS was better in patients receiving IV (RR=0.53; P=0.025) or oral Bu (RR=0.64; P=0.017) compared to TBI. In CML in first chronic phase, Cy in combination with IV Bu was associated with less relapse than TBI or oral Bu. LFS was better following IV or oral Bu compared to TBI.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9600628</journal-id><journal-id journal-id-type="pubmed-jr-id">20830</journal-id><journal-id journal-id-type="nlm-ta">Biol Blood Marrow Transplant</journal-id><journal-id journal-id-type="iso-abbrev">Biol. Blood Marrow Transplant.</journal-id><journal-title-group><journal-title>Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</journal-title></journal-title-group><issn pub-type="ppub">1083-8791</issn><issn pub-type="epub">1523-6536</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25528388</article-id><article-id pub-id-type="pmc">4329042</article-id><article-id pub-id-type="doi">10.1016/j.bbmt.2014.12.010</article-id><article-id pub-id-type="manuscript">NIHMS650721</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Comparison of Outcomes of Allogeneic Transplantation for CML with Cyclophosphamide in Combination with Intravenous Busulfan, Oral Busulfan or TBI</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Copelan</surname><given-names>Edward A.</given-names></name><degrees>MD, FACP</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Avalos</surname><given-names>Belinda</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ahn</surname><given-names>Kwang Woo</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Zhu</surname><given-names>Xiaochun</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Gale</surname><given-names>Robert Peter</given-names></name><degrees>MD, PhD, DSc(hon), FACP</degrees><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Grunwald</surname><given-names>Michael R.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Hamadani</surname><given-names>Mehdi</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Hamilton</surname><given-names>Betty K.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Hale</surname><given-names>Gregory A.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Marks</surname><given-names>David I.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Waller</surname><given-names>Edmund K.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Savani</surname><given-names>Bipin N.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Costa</surname><given-names>Luciano J.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Ramanathan</surname><given-names>Muthalagu</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Cahn</surname><given-names>Jean-Yves</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Khoury</surname><given-names>H. Jean</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Weisdorf</surname><given-names>Daniel J.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Inamoto</surname><given-names>Yoshihiro</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Kamble</surname><given-names>Rammurti T.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Schouten</surname><given-names>Harry C.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Wirk</surname><given-names>Baldeep</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Litzow</surname><given-names>Mark R.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Aljurf</surname><given-names>Mahmoud D.</given-names></name><degrees>MD, MPH</degrees><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>van Besien</surname><given-names>Koen W.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Ustun</surname><given-names>Celalettin</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Bolwell</surname><given-names>Brian J.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Bredeson</surname><given-names>Christopher N.</given-names></name><degrees>MD, MSc</degrees><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Fasan</surname><given-names>Omotayo</given-names></name><degrees>MD, MRCP</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ghosh</surname><given-names>Nilanjan</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Horowitz</surname><given-names>Mary M.</given-names></name><degrees>MD, MS</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Arora</surname><given-names>Mukta</given-names></name><degrees>MD, MS</degrees><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Szer</surname><given-names>Jeffrey</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Loren</surname><given-names>Alison W.</given-names></name><degrees>MD, MS</degrees><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Alyea</surname><given-names>Edwin P.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Cortes</surname><given-names>Jorge</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A25">25</xref></contrib><contrib contrib-type="author"><name><surname>Maziarz</surname><given-names>Richard T.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Kalaycio</surname><given-names>Matt E.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Saber</surname><given-names>Wael</given-names></name><degrees>MD, MS</degrees><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label>Levine Cancer Institute, Carolinas Healthcare System, Charlotte, NC</aff><aff id="A2"><label>2</label>Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI</aff><aff id="A3"><label>3</label>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</aff><aff id="A4"><label>4</label>Hematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College of London, United Kingdom</aff><aff id="A5"><label>5</label>Department of Hematology and Oncology, Cleveland Clinic, Cleveland, OH</aff><aff id="A6"><label>6</label>Department of Hematology/Oncology, All Children’s Hospital, St. Petersburg, FL</aff><aff id="A7"><label>7</label>University Hospitals Bristol NHS Trust, Bristol, United Kingdom</aff><aff id="A8"><label>8</label>Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA</aff><aff id="A9"><label>9</label>Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN</aff><aff id="A10"><label>10</label>Division of Hematology/Oncology, Department of Medicine, Medical University of South Carolina, Charleston, SC</aff><aff id="A11"><label>11</label>UMass Memorial Medical Center, Worcester, MA</aff><aff id="A12"><label>12</label>Department of Hematology, University Hospital, Grenoble, France</aff><aff id="A13"><label>13</label>Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis, MN</aff><aff id="A14"><label>14</label>Fred Hutchinson Cancer Research Center, Seattle, WA</aff><aff id="A15"><label>15</label>Division of Hematology and Oncology, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX</aff><aff id="A16"><label>16</label>Divison of Hematology, Academische Ziekenhuis Maastricht, Maastricht, Netherlands</aff><aff id="A17"><label>17</label>Department of Internal Medicine, Stony Brook University Medical Center, Stony Brook, NY</aff><aff id="A18"><label>18</label>Mayo Clinic, Rochester, MN</aff><aff id="A19"><label>19</label>Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh, Saudi Arabia</aff><aff id="A20"><label>20</label>Department of Medical Oncology, Weill Cornell Medical College, New York, NY</aff><aff id="A21"><label>21</label>The Ottawa Hospital Blood & Marrow Transplant Program and the Ottawa Hospital Research Institute, Ottawa, ON, Canada</aff><aff id="A22"><label>22</label>Department of Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital, Victoria, Australia</aff><aff id="A23"><label>23</label>Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</aff><aff id="A24"><label>24</label>Center of Hematologic Oncology, Dana-Farber Cancer Institute, Boston, MA</aff><aff id="A25"><label>25</label>Department of Leukemia, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX</aff><aff id="A26"><label>26</label>Center for Hematologic Malignancies, Oregon Health and Science University, Portland, OR</aff><author-notes><corresp id="CR1"><bold>Corresponding Author:</bold> Edward A. Copelan, MD; Levine Cancer Institute, 1021 Morehead Medical Drive, Suite 5300, Charlotte, NC, 28204; Telephone: 980-442-3104; Fax: 980-442-3101; <email>Edward.Copelan@carolinashealthcare.org</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>25</day><month>12</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>17</day><month>12</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>3</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>3</month><year>2016</year></pub-date><volume>21</volume><issue>3</issue><fpage>552</fpage><lpage>558</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.bbmt.2014.12.010</pmc-comment>
<abstract><p id="P1">Cyclophosphamide in combination with busulfan (Bu) or total body irradiation (TBI) are the most commonly used myeloablative conditioning regimens in patients with Chronic Myeloid Leukemia (CML). We used data from the Center for International Bone Marrow Transplantation Research to compare outcomes in adults who underwent hematopoietic cell transplantation for CML in first chronic phase following myeloablative conditioning with cyclophosphamide (Cy) in combination with TBI, oral Bu or intravenous (IV) Bu. Four hundred thirty-eight adults received human leukocyte antigen (HLA)-matched sibling grafts and 235 received well-matched grafts from unrelated donors from 2000 through 2006. Important differences existed between the groups in distribution of donor relation, exposure to tyrosine kinase inhibitors and year of transplantation. In multivariate analysis, relapse occurred less frequently among patients receiving IV Bu compared to TBI (RR=0.36; P=0.022) or oral Bu (RR=0.39; P=0.028), but non-relapse mortality and survival were similar. A significant interaction was detected between donor relation and the main effect in leukemia-free survival (LFS). Among recipients of HLA-identical sibling grafts, but not URD grafts, LFS was better in patients receiving IV (RR=0.53; P=0.025) or oral Bu (RR=0.64; P=0.017) compared to TBI. In CML in first chronic phase, Cy in combination with IV Bu was associated with less relapse than TBI or oral Bu. LFS was better following IV or oral Bu compared to TBI.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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