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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">REDUCED INTENSITY HEMATOPOIETIC CELL TRANSPLANTATION FOR PATIENTS WITH PRIMARY MYELOFIBROSIS: A COHORT ANALYSIS FROM THE CENTER FOR INTERNATIONAL BLOOD AND MARROW TRANSPLANT RESEARCH</title><author><name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name><affiliation><nlm:aff id="A1">Princess Margaret Cancer Center, University of Toronto, Toronto, CANADA</nlm:aff></affiliation></author><author><name sortKey="Malone, Adriana K" sort="Malone, Adriana K" uniqKey="Malone A" first="Adriana K." last="Malone">Adriana K. Malone</name><affiliation><nlm:aff id="A2">Mount Sinai Medical Center, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Hari, Parameswaran N" sort="Hari, Parameswaran N" uniqKey="Hari P" first="Parameswaran N." last="Hari">Parameswaran N. Hari</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Hu, Zhen Huan" sort="Hu, Zhen Huan" uniqKey="Hu Z" first="Zhen-Huan" last="Hu">Zhen-Huan Hu</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name><affiliation><nlm:aff id="A4">Imperial College, Section of Hematology, Division of Experimental Medicine, Department of Medicine, London, UNITED KINGDOM</nlm:aff></affiliation></author><author><name sortKey="Ballen, Karen K" sort="Ballen, Karen K" uniqKey="Ballen K" first="Karen K." last="Ballen">Karen K. Ballen</name><affiliation><nlm:aff id="A5">Massachusetts General Hospital, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name><affiliation><nlm:aff id="A6">West Virginia University Hospitals, Inc., Morgantown, WV</nlm:aff></affiliation></author><author><name sortKey="Olavarria, Eduardo" sort="Olavarria, Eduardo" uniqKey="Olavarria E" first="Eduardo" last="Olavarria">Eduardo Olavarria</name><affiliation><nlm:aff id="A7">Hematology Department and BMT Unit, Complejo Hospitalario de Navarra, Pamplona, SPAIN</nlm:aff></affiliation></author><author><name sortKey="Gerds, Aaron T" sort="Gerds, Aaron T" uniqKey="Gerds A" first="Aaron T." last="Gerds">Aaron T. Gerds</name><affiliation><nlm:aff id="A8">Cleveland Clinic Taussig Cancer Institute, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Waller, Edmund K" sort="Waller, Edmund K" uniqKey="Waller E" first="Edmund K." last="Waller">Edmund K. Waller</name><affiliation><nlm:aff id="A9">Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta, GA</nlm:aff></affiliation></author><author><name sortKey="Costa, Luciano J" sort="Costa, Luciano J" uniqKey="Costa L" first="Luciano J." last="Costa">Luciano J. Costa</name><affiliation><nlm:aff id="A10">Blood and Marrow Transplant Program, Medical University of South Carolina, Charleston, SC</nlm:aff></affiliation></author><author><name sortKey="Antin, Joseph H" sort="Antin, Joseph H" uniqKey="Antin J" first="Joseph H." last="Antin">Joseph H. Antin</name><affiliation><nlm:aff id="A11">Dana Farber Cancer Institute, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Kamble, Rammurti T" sort="Kamble, Rammurti T" uniqKey="Kamble R" first="Rammurti T." last="Kamble">Rammurti T. Kamble</name><affiliation><nlm:aff id="A12">Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX</nlm:aff></affiliation></author><author><name sortKey="Van Besien, Koen M" sort="Van Besien, Koen M" uniqKey="Van Besien K" first="Koen M." last="Van Besien">Koen M. Van Besien</name><affiliation><nlm:aff id="A13">Stem Cell Transplant, Weill Cornell Medical College, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name><affiliation><nlm:aff id="A14">Vanderbilt University Medical Center, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name><affiliation><nlm:aff id="A15">Academische Ziekenhuis Maastricht, Maastricht, NETHERLANDS</nlm:aff></affiliation></author><author><name sortKey="Szer, Jeffrey" sort="Szer, Jeffrey" uniqKey="Szer J" first="Jeffrey" last="Szer">Jeffrey Szer</name><affiliation><nlm:aff id="A16">Clinical Haematology and BMT Service, Royal Melbourne Hospital, Victoria, AUSTRALIA</nlm:aff></affiliation></author><author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name><affiliation><nlm:aff id="A17">Department of Hematology, University Hospital, Grenoble, FRANCE</nlm:aff></affiliation></author><author><name sortKey="De Lima, Marcos J" sort="De Lima, Marcos J" uniqKey="De Lima M" first="Marcos J." last="De Lima">Marcos J. De Lima</name><affiliation><nlm:aff id="A18">Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name><affiliation><nlm:aff id="A19">Department of Hematology/Oncology, Shands HealthCare and University of Florida, Gainesville, FL</nlm:aff></affiliation></author><author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name><affiliation><nlm:aff id="A20">King Faisal Specialist Hospital and Research Center, Riyadh, SAUDI ARABIA</nlm:aff></affiliation></author><author><name sortKey="Popat, Uday" sort="Popat, Uday" uniqKey="Popat U" first="Uday" last="Popat">Uday Popat</name><affiliation><nlm:aff id="A21">Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston, TX</nlm:aff></affiliation></author><author><name sortKey="Bejanyan, Nelli" sort="Bejanyan, Nelli" uniqKey="Bejanyan N" first="Nelli" last="Bejanyan">Nelli Bejanyan</name><affiliation><nlm:aff id="A22">Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff></affiliation></author><author><name sortKey="Litzow, Mark R" sort="Litzow, Mark R" uniqKey="Litzow M" first="Mark R." last="Litzow">Mark R. Litzow</name><affiliation><nlm:aff id="A23">Mayo Clinic Rochester, Rochester, MN</nlm:aff></affiliation></author><author><name sortKey="Norkin, Maxim" sort="Norkin, Maxim" uniqKey="Norkin M" first="Maxim" last="Norkin">Maxim Norkin</name><affiliation><nlm:aff id="A19">Department of Hematology/Oncology, Shands HealthCare and University of Florida, Gainesville, FL</nlm:aff></affiliation></author><author><name sortKey="Lewis, Ian D" sort="Lewis, Ian D" uniqKey="Lewis I" first="Ian D." last="Lewis">Ian D. Lewis</name><affiliation><nlm:aff id="A24">Haematology and Bone Marrow Transplant Unit, Royal Adelaide Hospital/SA Pathology, Adelaide, AUSTRALIA</nlm:aff></affiliation></author><author><name sortKey="Hale, Gregory A" sort="Hale, Gregory A" uniqKey="Hale G" first="Gregory A." last="Hale">Gregory A. Hale</name><affiliation><nlm:aff id="A25">All Children's Hospital, St. Petersburg, FL</nlm:aff></affiliation></author><author><name sortKey="Woolfrey, Ann E" sort="Woolfrey, Ann E" uniqKey="Woolfrey A" first="Ann E." last="Woolfrey">Ann E. Woolfrey</name><affiliation><nlm:aff id="A8">Cleveland Clinic Taussig Cancer Institute, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Miller, Alan M" sort="Miller, Alan M" uniqKey="Miller A" first="Alan M." last="Miller">Alan M. Miller</name><affiliation><nlm:aff id="A26">Baylor University Medical Center, Dallas, TX</nlm:aff></affiliation></author><author><name sortKey="Ustun, Celalettin" sort="Ustun, Celalettin" uniqKey="Ustun C" first="Celalettin" last="Ustun">Celalettin Ustun</name><affiliation><nlm:aff id="A22">Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff></affiliation></author><author><name sortKey="Jagasia, Madan H" sort="Jagasia, Madan H" uniqKey="Jagasia M" first="Madan H." last="Jagasia">Madan H. Jagasia</name><affiliation><nlm:aff id="A14">Vanderbilt University Medical Center, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Lill, Michael" sort="Lill, Michael" uniqKey="Lill M" first="Michael" last="Lill">Michael Lill</name><affiliation><nlm:aff id="A27">Division of Hematology/Oncology, Cedars-Sinai Medical Center, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Maziarz, Richard T" sort="Maziarz, Richard T" uniqKey="Maziarz R" first="Richard T." last="Maziarz">Richard T. Maziarz</name><affiliation><nlm:aff id="A28">Center for Hematologic Malignancies, Oregon Health and Science University, Portland, OR</nlm:aff></affiliation></author><author><name sortKey="Cortes, Jorge" sort="Cortes, Jorge" uniqKey="Cortes J" first="Jorge" last="Cortes">Jorge Cortes</name><affiliation><nlm:aff id="A21">Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston, TX</nlm:aff></affiliation></author><author><name sortKey="Kalaycio, Matt E" sort="Kalaycio, Matt E" uniqKey="Kalaycio M" first="Matt E." last="Kalaycio">Matt E. Kalaycio</name><affiliation><nlm:aff id="A8">Cleveland Clinic Taussig Cancer Institute, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24161923</idno><idno type="pmc">3886623</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886623</idno><idno type="RBID">PMC:3886623</idno><idno type="doi">10.1016/j.bbmt.2013.10.018</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">002187</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002187</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">REDUCED INTENSITY HEMATOPOIETIC CELL TRANSPLANTATION FOR PATIENTS WITH PRIMARY MYELOFIBROSIS: A COHORT ANALYSIS FROM THE CENTER FOR INTERNATIONAL BLOOD AND MARROW TRANSPLANT RESEARCH</title><author><name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name><affiliation><nlm:aff id="A1">Princess Margaret Cancer Center, University of Toronto, Toronto, CANADA</nlm:aff></affiliation></author><author><name sortKey="Malone, Adriana K" sort="Malone, Adriana K" uniqKey="Malone A" first="Adriana K." last="Malone">Adriana K. Malone</name><affiliation><nlm:aff id="A2">Mount Sinai Medical Center, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Hari, Parameswaran N" sort="Hari, Parameswaran N" uniqKey="Hari P" first="Parameswaran N." last="Hari">Parameswaran N. Hari</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Hu, Zhen Huan" sort="Hu, Zhen Huan" uniqKey="Hu Z" first="Zhen-Huan" last="Hu">Zhen-Huan Hu</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name><affiliation><nlm:aff id="A4">Imperial College, Section of Hematology, Division of Experimental Medicine, Department of Medicine, London, UNITED KINGDOM</nlm:aff></affiliation></author><author><name sortKey="Ballen, Karen K" sort="Ballen, Karen K" uniqKey="Ballen K" first="Karen K." last="Ballen">Karen K. Ballen</name><affiliation><nlm:aff id="A5">Massachusetts General Hospital, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name><affiliation><nlm:aff id="A6">West Virginia University Hospitals, Inc., Morgantown, WV</nlm:aff></affiliation></author><author><name sortKey="Olavarria, Eduardo" sort="Olavarria, Eduardo" uniqKey="Olavarria E" first="Eduardo" last="Olavarria">Eduardo Olavarria</name><affiliation><nlm:aff id="A7">Hematology Department and BMT Unit, Complejo Hospitalario de Navarra, Pamplona, SPAIN</nlm:aff></affiliation></author><author><name sortKey="Gerds, Aaron T" sort="Gerds, Aaron T" uniqKey="Gerds A" first="Aaron T." last="Gerds">Aaron T. Gerds</name><affiliation><nlm:aff id="A8">Cleveland Clinic Taussig Cancer Institute, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Waller, Edmund K" sort="Waller, Edmund K" uniqKey="Waller E" first="Edmund K." last="Waller">Edmund K. Waller</name><affiliation><nlm:aff id="A9">Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta, GA</nlm:aff></affiliation></author><author><name sortKey="Costa, Luciano J" sort="Costa, Luciano J" uniqKey="Costa L" first="Luciano J." last="Costa">Luciano J. Costa</name><affiliation><nlm:aff id="A10">Blood and Marrow Transplant Program, Medical University of South Carolina, Charleston, SC</nlm:aff></affiliation></author><author><name sortKey="Antin, Joseph H" sort="Antin, Joseph H" uniqKey="Antin J" first="Joseph H." last="Antin">Joseph H. Antin</name><affiliation><nlm:aff id="A11">Dana Farber Cancer Institute, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Kamble, Rammurti T" sort="Kamble, Rammurti T" uniqKey="Kamble R" first="Rammurti T." last="Kamble">Rammurti T. Kamble</name><affiliation><nlm:aff id="A12">Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX</nlm:aff></affiliation></author><author><name sortKey="Van Besien, Koen M" sort="Van Besien, Koen M" uniqKey="Van Besien K" first="Koen M." last="Van Besien">Koen M. Van Besien</name><affiliation><nlm:aff id="A13">Stem Cell Transplant, Weill Cornell Medical College, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name><affiliation><nlm:aff id="A14">Vanderbilt University Medical Center, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name><affiliation><nlm:aff id="A15">Academische Ziekenhuis Maastricht, Maastricht, NETHERLANDS</nlm:aff></affiliation></author><author><name sortKey="Szer, Jeffrey" sort="Szer, Jeffrey" uniqKey="Szer J" first="Jeffrey" last="Szer">Jeffrey Szer</name><affiliation><nlm:aff id="A16">Clinical Haematology and BMT Service, Royal Melbourne Hospital, Victoria, AUSTRALIA</nlm:aff></affiliation></author><author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name><affiliation><nlm:aff id="A17">Department of Hematology, University Hospital, Grenoble, FRANCE</nlm:aff></affiliation></author><author><name sortKey="De Lima, Marcos J" sort="De Lima, Marcos J" uniqKey="De Lima M" first="Marcos J." last="De Lima">Marcos J. De Lima</name><affiliation><nlm:aff id="A18">Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name><affiliation><nlm:aff id="A19">Department of Hematology/Oncology, Shands HealthCare and University of Florida, Gainesville, FL</nlm:aff></affiliation></author><author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name><affiliation><nlm:aff id="A20">King Faisal Specialist Hospital and Research Center, Riyadh, SAUDI ARABIA</nlm:aff></affiliation></author><author><name sortKey="Popat, Uday" sort="Popat, Uday" uniqKey="Popat U" first="Uday" last="Popat">Uday Popat</name><affiliation><nlm:aff id="A21">Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston, TX</nlm:aff></affiliation></author><author><name sortKey="Bejanyan, Nelli" sort="Bejanyan, Nelli" uniqKey="Bejanyan N" first="Nelli" last="Bejanyan">Nelli Bejanyan</name><affiliation><nlm:aff id="A22">Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff></affiliation></author><author><name sortKey="Litzow, Mark R" sort="Litzow, Mark R" uniqKey="Litzow M" first="Mark R." last="Litzow">Mark R. Litzow</name><affiliation><nlm:aff id="A23">Mayo Clinic Rochester, Rochester, MN</nlm:aff></affiliation></author><author><name sortKey="Norkin, Maxim" sort="Norkin, Maxim" uniqKey="Norkin M" first="Maxim" last="Norkin">Maxim Norkin</name><affiliation><nlm:aff id="A19">Department of Hematology/Oncology, Shands HealthCare and University of Florida, Gainesville, FL</nlm:aff></affiliation></author><author><name sortKey="Lewis, Ian D" sort="Lewis, Ian D" uniqKey="Lewis I" first="Ian D." last="Lewis">Ian D. Lewis</name><affiliation><nlm:aff id="A24">Haematology and Bone Marrow Transplant Unit, Royal Adelaide Hospital/SA Pathology, Adelaide, AUSTRALIA</nlm:aff></affiliation></author><author><name sortKey="Hale, Gregory A" sort="Hale, Gregory A" uniqKey="Hale G" first="Gregory A." last="Hale">Gregory A. Hale</name><affiliation><nlm:aff id="A25">All Children's Hospital, St. Petersburg, FL</nlm:aff></affiliation></author><author><name sortKey="Woolfrey, Ann E" sort="Woolfrey, Ann E" uniqKey="Woolfrey A" first="Ann E." last="Woolfrey">Ann E. Woolfrey</name><affiliation><nlm:aff id="A8">Cleveland Clinic Taussig Cancer Institute, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Miller, Alan M" sort="Miller, Alan M" uniqKey="Miller A" first="Alan M." last="Miller">Alan M. Miller</name><affiliation><nlm:aff id="A26">Baylor University Medical Center, Dallas, TX</nlm:aff></affiliation></author><author><name sortKey="Ustun, Celalettin" sort="Ustun, Celalettin" uniqKey="Ustun C" first="Celalettin" last="Ustun">Celalettin Ustun</name><affiliation><nlm:aff id="A22">Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff></affiliation></author><author><name sortKey="Jagasia, Madan H" sort="Jagasia, Madan H" uniqKey="Jagasia M" first="Madan H." last="Jagasia">Madan H. Jagasia</name><affiliation><nlm:aff id="A14">Vanderbilt University Medical Center, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Lill, Michael" sort="Lill, Michael" uniqKey="Lill M" first="Michael" last="Lill">Michael Lill</name><affiliation><nlm:aff id="A27">Division of Hematology/Oncology, Cedars-Sinai Medical Center, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Maziarz, Richard T" sort="Maziarz, Richard T" uniqKey="Maziarz R" first="Richard T." last="Maziarz">Richard T. Maziarz</name><affiliation><nlm:aff id="A28">Center for Hematologic Malignancies, Oregon Health and Science University, Portland, OR</nlm:aff></affiliation></author><author><name sortKey="Cortes, Jorge" sort="Cortes, Jorge" uniqKey="Cortes J" first="Jorge" last="Cortes">Jorge Cortes</name><affiliation><nlm:aff id="A21">Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston, TX</nlm:aff></affiliation></author><author><name sortKey="Kalaycio, Matt E" sort="Kalaycio, Matt E" uniqKey="Kalaycio M" first="Matt E." last="Kalaycio">Matt E. Kalaycio</name><affiliation><nlm:aff id="A8">Cleveland Clinic Taussig Cancer Institute, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author></analytic><series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title><idno type="ISSN">1083-8791</idno><idno type="eISSN">1523-6536</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">We evaluated the outcomes and associated prognostic factors in 233 patients undergoing allogeneic hematopoietic cell transplantation (HCT) for primary myelofibrosis (MF) using reduced intensity conditioning (RIC). Median age at HCT was 55 years. Donors were: matched sibling donor (MSD), 34%; HLA-well-matched unrelated donors (URD), 45%; and partially/mismatched URD, 21%. Risk stratification according to Dynamic International Prognostic Scoring System (DIPSS): low, 12%; intermediate-1, 49%; intermediate-2, 37%; and high, 1%. The probability of survival at 5-years was 47% (95% CI 40–53). In a multivariate analysis, donor type was the only independent factor associated with survival. Adjusted probabilities of survival at 5-years for MSD, well matched URD and partially matched/mismatched URD were 56% (95% CI 44–67), 48% (95% CI 37–58), and 34% (95% CI 21–47), respectively (p=0.002). Relative risks (RR) for NRM for well-matched URD and partially matched/mismatched URD were 3.92 (p=0.006) and 9.37 (p<0.0001), respectively. A trend towards increased NRM (RR 1.7, p=0.07) and inferior survival (RR 1.37, p=0.10) was observed in DIPSS-intermediate-2/high-risk patients compared to DIPSS-low/intermediate-1 risk patients.</p><p id="P2">RIC HCT is a potentially curative option for patients with MF, and donor type is the most important factor influencing survival in these patients.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9600628</journal-id><journal-id journal-id-type="pubmed-jr-id">20830</journal-id><journal-id journal-id-type="nlm-ta">Biol Blood Marrow Transplant</journal-id><journal-id journal-id-type="iso-abbrev">Biol. Blood Marrow Transplant.</journal-id><journal-title-group><journal-title>Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</journal-title></journal-title-group><issn pub-type="ppub">1083-8791</issn><issn pub-type="epub">1523-6536</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24161923</article-id><article-id pub-id-type="pmc">3886623</article-id><article-id pub-id-type="doi">10.1016/j.bbmt.2013.10.018</article-id><article-id pub-id-type="manuscript">NIHMS544568</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>REDUCED INTENSITY HEMATOPOIETIC CELL TRANSPLANTATION FOR PATIENTS WITH PRIMARY MYELOFIBROSIS: A COHORT ANALYSIS FROM THE CENTER FOR INTERNATIONAL BLOOD AND MARROW TRANSPLANT RESEARCH</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Gupta</surname><given-names>Vikas</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Malone</surname><given-names>Adriana K.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Hari</surname><given-names>Parameswaran N.</given-names></name><degrees>MD, MS</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Ahn</surname><given-names>Kwang Woo</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Hu</surname><given-names>Zhen-Huan</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Gale</surname><given-names>Robert Peter</given-names></name><degrees>MD, PhD, DSc(hon); FACP</degrees><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Ballen</surname><given-names>Karen K.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Hamadani</surname><given-names>Mehdi</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Olavarria</surname><given-names>Eduardo</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Gerds</surname><given-names>Aaron T.</given-names></name><degrees>MD, MS</degrees><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Waller</surname><given-names>Edmund K.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Costa</surname><given-names>Luciano J.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Antin</surname><given-names>Joseph H.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Kamble</surname><given-names>Rammurti T.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>van Besien</surname><given-names>Koen M.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Savani</surname><given-names>Bipin N.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Schouten</surname><given-names>Harry C.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Szer</surname><given-names>Jeffrey</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Cahn</surname><given-names>Jean-Yves</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>de Lima</surname><given-names>Marcos J.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Wirk</surname><given-names>Baldeep</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Aljurf</surname><given-names>Mahmoud D.</given-names></name><degrees>MD, MPH</degrees><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Popat</surname><given-names>Uday</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Bejanyan</surname><given-names>Nelli</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Litzow</surname><given-names>Mark R.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Norkin</surname><given-names>Maxim</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Lewis</surname><given-names>Ian D.</given-names></name><degrees>MBBS, PhD</degrees><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Hale</surname><given-names>Gregory A.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A25">25</xref></contrib><contrib contrib-type="author"><name><surname>Woolfrey</surname><given-names>Ann E.</given-names></name><degrees>MD, BA</degrees><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Miller</surname><given-names>Alan M.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Ustun</surname><given-names>Celalettin</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Jagasia</surname><given-names>Madan H.</given-names></name><degrees>MBBS, MS</degrees><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Lill</surname><given-names>Michael</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Maziarz</surname><given-names>Richard T.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A28">28</xref></contrib><contrib contrib-type="author"><name><surname>Cortes</surname><given-names>Jorge</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Kalaycio</surname><given-names>Matt E.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Saber</surname><given-names>Wael</given-names></name><degrees>MD, MS</degrees><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label>Princess Margaret Cancer Center, University of Toronto, Toronto, CANADA</aff><aff id="A2"><label>2</label>Mount Sinai Medical Center, New York, NY</aff><aff id="A3"><label>3</label>Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</aff><aff id="A4"><label>4</label>Imperial College, Section of Hematology, Division of Experimental Medicine, Department of Medicine, London, UNITED KINGDOM</aff><aff id="A5"><label>5</label>Massachusetts General Hospital, Boston, MA</aff><aff id="A6"><label>6</label>West Virginia University Hospitals, Inc., Morgantown, WV</aff><aff id="A7"><label>7</label>Hematology Department and BMT Unit, Complejo Hospitalario de Navarra, Pamplona, SPAIN</aff><aff id="A8"><label>8</label>Cleveland Clinic Taussig Cancer Institute, Cleveland, OH</aff><aff id="A9"><label>9</label>Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta, GA</aff><aff id="A10"><label>10</label>Blood and Marrow Transplant Program, Medical University of South Carolina, Charleston, SC</aff><aff id="A11"><label>11</label>Dana Farber Cancer Institute, Boston, MA</aff><aff id="A12"><label>12</label>Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX</aff><aff id="A13"><label>13</label>Stem Cell Transplant, Weill Cornell Medical College, New York, NY</aff><aff id="A14"><label>14</label>Vanderbilt University Medical Center, Nashville, TN</aff><aff id="A15"><label>15</label>Academische Ziekenhuis Maastricht, Maastricht, NETHERLANDS</aff><aff id="A16"><label>16</label>Clinical Haematology and BMT Service, Royal Melbourne Hospital, Victoria, AUSTRALIA</aff><aff id="A17"><label>17</label>Department of Hematology, University Hospital, Grenoble, FRANCE</aff><aff id="A18"><label>18</label>Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH</aff><aff id="A19"><label>19</label>Department of Hematology/Oncology, Shands HealthCare and University of Florida, Gainesville, FL</aff><aff id="A20"><label>20</label>King Faisal Specialist Hospital and Research Center, Riyadh, SAUDI ARABIA</aff><aff id="A21"><label>21</label>Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston, TX</aff><aff id="A22"><label>22</label>Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical Center, Minneapolis, MN</aff><aff id="A23"><label>23</label>Mayo Clinic Rochester, Rochester, MN</aff><aff id="A24"><label>24</label>Haematology and Bone Marrow Transplant Unit, Royal Adelaide Hospital/SA Pathology, Adelaide, AUSTRALIA</aff><aff id="A25"><label>25</label>All Children's Hospital, St. Petersburg, FL</aff><aff id="A26"><label>26</label>Baylor University Medical Center, Dallas, TX</aff><aff id="A27"><label>27</label>Division of Hematology/Oncology, Cedars-Sinai Medical Center, Los Angeles, CA</aff><aff id="A28"><label>28</label>Center for Hematologic Malignancies, Oregon Health and Science University, Portland, OR</aff><author-notes><corresp id="CR1"><bold>Corresponding author:</bold> Vikas Gupta, MD; Princess Margaret Cancer Center, 610 University Avenue, Suite 5-217, Toronto, ON M5G2M9, Canada; Phone: 416-946-4521; Fax: 416-946-6546; <email>vikas.gupta@uhn.on.ca</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>2</day><month>1</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>23</day><month>10</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>1</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>1</month><year>2015</year></pub-date><volume>20</volume><issue>1</issue><elocation-id>10.1016/j.bbmt.2013.10.018</elocation-id><permissions><copyright-statement>© 2013 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved</copyright-statement><copyright-year>2013</copyright-year></permissions><abstract><p id="P1">We evaluated the outcomes and associated prognostic factors in 233 patients undergoing allogeneic hematopoietic cell transplantation (HCT) for primary myelofibrosis (MF) using reduced intensity conditioning (RIC). Median age at HCT was 55 years. Donors were: matched sibling donor (MSD), 34%; HLA-well-matched unrelated donors (URD), 45%; and partially/mismatched URD, 21%. Risk stratification according to Dynamic International Prognostic Scoring System (DIPSS): low, 12%; intermediate-1, 49%; intermediate-2, 37%; and high, 1%. The probability of survival at 5-years was 47% (95% CI 40–53). In a multivariate analysis, donor type was the only independent factor associated with survival. Adjusted probabilities of survival at 5-years for MSD, well matched URD and partially matched/mismatched URD were 56% (95% CI 44–67), 48% (95% CI 37–58), and 34% (95% CI 21–47), respectively (p=0.002). Relative risks (RR) for NRM for well-matched URD and partially matched/mismatched URD were 3.92 (p=0.006) and 9.37 (p<0.0001), respectively. A trend towards increased NRM (RR 1.7, p=0.07) and inferior survival (RR 1.37, p=0.10) was observed in DIPSS-intermediate-2/high-risk patients compared to DIPSS-low/intermediate-1 risk patients.</p><p id="P2">RIC HCT is a potentially curative option for patients with MF, and donor type is the most important factor influencing survival in these patients.</p></abstract><kwd-group><kwd>Myelofibrosis</kwd><kwd>allogeneic transplantation</kwd><kwd>reduced intensity</kwd><kwd>prognosis</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>U10 HL069294 || HL</award-id></award-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>T32 HL007093 || HL</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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