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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Allogeneic Hematopoietic Cell Transplantation for Advanced Polycythemia Vera and Essential Thrombocythemia</title><author><name sortKey="Ballen, Karen K" sort="Ballen, Karen K" uniqKey="Ballen K" first="Karen K." last="Ballen">Karen K. Ballen</name><affiliation><nlm:aff id="A1">Division of Hematology/Oncology, Massachusetts General Hospital, Boston, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Woolfrey, Ann E" sort="Woolfrey, Ann E" uniqKey="Woolfrey A" first="Ann E." last="Woolfrey">Ann E. Woolfrey</name><affiliation><nlm:aff id="A2">Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Zhu, Xiaochun" sort="Zhu, Xiaochun" uniqKey="Zhu X" first="Xiaochun" last="Zhu">Xiaochun Zhu</name><affiliation><nlm:aff id="A3">Department of Medicine, Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, Wisconsin</nlm:aff></affiliation></author><author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name><affiliation><nlm:aff id="A4">Division of Biostatistics, Medical College of Wisconsin, Milwaukee, Wisconsin</nlm:aff></affiliation></author><author><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name><affiliation><nlm:aff id="A5">Department of Hematology/Oncology, Shands Healthcare, University of Florida, Gainesville, Florida</nlm:aff></affiliation></author><author><name sortKey="Arora, Mukta" sort="Arora, Mukta" uniqKey="Arora M" first="Mukta" last="Arora">Mukta Arora</name><affiliation><nlm:aff id="A6">Department of Hematology, Oncology and Transplant, University of Minnesota Medical Center, Minneapolis, Minnesota</nlm:aff></affiliation></author><author><name sortKey="George, Biju" sort="George, Biju" uniqKey="George B" first="Biju" last="George">Biju George</name><affiliation><nlm:aff id="A7">Department of Hematology, Christian Medical College Hospital, Vellore, Tamil Nadu, India</nlm:aff></affiliation></author><author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name><affiliation><nlm:aff id="A8">Vanderbilt University Medical Center, Brentwood, Tennessee</nlm:aff></affiliation></author><author><name sortKey="Bolwell, Brian" sort="Bolwell, Brian" uniqKey="Bolwell B" first="Brian" last="Bolwell">Brian Bolwell</name><affiliation><nlm:aff id="A9">Department of Bone Marrow Transplant, Cleveland Clinic, Cleveland, Ohio</nlm:aff></affiliation></author><author><name sortKey="Porter, David L" sort="Porter, David L" uniqKey="Porter D" first="David L." last="Porter">David L. Porter</name><affiliation><nlm:aff id="A10">Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania</nlm:aff></affiliation></author><author><name sortKey="Copelan, Ed" sort="Copelan, Ed" uniqKey="Copelan E" first="Ed" last="Copelan">Ed Copelan</name><affiliation><nlm:aff id="A9">Department of Bone Marrow Transplant, Cleveland Clinic, Cleveland, Ohio</nlm:aff></affiliation></author><author><name sortKey="Hale, Gregory" sort="Hale, Gregory" uniqKey="Hale G" first="Gregory" last="Hale">Gregory Hale</name><affiliation><nlm:aff id="A11">Department of Pediatric Hematology/Oncology/BMT, All Children’s Hospital, St. Petersburg, Florida</nlm:aff></affiliation></author><author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name><affiliation><nlm:aff id="A12">Interne Geneeskunde, Academische Ziekenhuis Maastricht, Maastricht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Lewis, Ian" sort="Lewis, Ian" uniqKey="Lewis I" first="Ian" last="Lewis">Ian Lewis</name><affiliation><nlm:aff id="A13">Haematology and Bone Marrow Transplant Unit, Royal Adelaïde Hôpital/South Australia Pathology, Adelaïde, South Australia</nlm:aff></affiliation></author><author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean Yves" last="Cahn">Jean Yves Cahn</name><affiliation><nlm:aff id="A14">Département d’Hématologie, Hôpital A. Michallon, CHU de Grenoble, Grenoble, France</nlm:aff></affiliation></author><author><name sortKey="Halter, Joerg" sort="Halter, Joerg" uniqKey="Halter J" first="Joerg" last="Halter">Joerg Halter</name><affiliation><nlm:aff id="A15">Department of Internal Medicine, University Hospital Basel, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Cortes, Jorge" sort="Cortes, Jorge" uniqKey="Cortes J" first="Jorge" last="Cortes">Jorge Cortes</name><affiliation><nlm:aff id="A16">MD Anderson Cancer Center, University of Texas, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Kalaycio, Matt E" sort="Kalaycio, Matt E" uniqKey="Kalaycio M" first="Matt E." last="Kalaycio">Matt E. Kalaycio</name><affiliation><nlm:aff id="A9">Department of Bone Marrow Transplant, Cleveland Clinic, Cleveland, Ohio</nlm:aff></affiliation></author><author><name sortKey="Antin, Joseph" sort="Antin, Joseph" uniqKey="Antin J" first="Joseph" last="Antin">Joseph Antin</name><affiliation><nlm:aff id="A17">Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name><affiliation><nlm:aff id="A18">Department of Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Carabasi, Matthew H" sort="Carabasi, Matthew H" uniqKey="Carabasi M" first="Matthew H." last="Carabasi">Matthew H. Carabasi</name><affiliation><nlm:aff id="A19">Department of Medical Oncology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania</nlm:aff></affiliation></author><author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name><affiliation><nlm:aff id="A20">Department of Hematology/Oncology, West Virginia University Hospitals, Inc., Morgantown, West Virginia</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Philip" sort="Mccarthy, Philip" uniqKey="Mccarthy P" first="Philip" last="Mccarthy">Philip Mccarthy</name><affiliation><nlm:aff id="A21">Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York</nlm:aff></affiliation></author><author><name sortKey="Pavletic, Steven" sort="Pavletic, Steven" uniqKey="Pavletic S" first="Steven" last="Pavletic">Steven Pavletic</name><affiliation><nlm:aff id="A22">Graft-vs-Host and Autoimmunity Unit, National Institutes of Health/National Cancer Institute, Bethesda, Maryland</nlm:aff></affiliation></author><author><name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name><affiliation><nlm:aff id="A23">Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Deeg, H Joachim" sort="Deeg, H Joachim" uniqKey="Deeg H" first="H. Joachim" last="Deeg">H. Joachim Deeg</name><affiliation><nlm:aff id="A2">Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Maziarz, Richard T" sort="Maziarz, Richard T" uniqKey="Maziarz R" first="Richard T." last="Maziarz">Richard T. Maziarz</name><affiliation><nlm:aff id="A24">Center for Hematologic Malignancies, Oregon Health and Science University, Portland, Oregon</nlm:aff></affiliation></author><author><name sortKey="Horowitz, Mary M" sort="Horowitz, Mary M" uniqKey="Horowitz M" first="Mary M." last="Horowitz">Mary M. Horowitz</name><affiliation><nlm:aff id="A3">Department of Medicine, Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, Wisconsin</nlm:aff></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation><nlm:aff id="A3">Department of Medicine, Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, Wisconsin</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22449610</idno><idno type="pmc">3499973</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499973</idno><idno type="RBID">PMC:3499973</idno><idno type="doi">10.1016/j.bbmt.2012.03.009</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002186</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002186</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Allogeneic Hematopoietic Cell Transplantation for Advanced Polycythemia Vera and Essential Thrombocythemia</title><author><name sortKey="Ballen, Karen K" sort="Ballen, Karen K" uniqKey="Ballen K" first="Karen K." last="Ballen">Karen K. Ballen</name><affiliation><nlm:aff id="A1">Division of Hematology/Oncology, Massachusetts General Hospital, Boston, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Woolfrey, Ann E" sort="Woolfrey, Ann E" uniqKey="Woolfrey A" first="Ann E." last="Woolfrey">Ann E. Woolfrey</name><affiliation><nlm:aff id="A2">Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Zhu, Xiaochun" sort="Zhu, Xiaochun" uniqKey="Zhu X" first="Xiaochun" last="Zhu">Xiaochun Zhu</name><affiliation><nlm:aff id="A3">Department of Medicine, Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, Wisconsin</nlm:aff></affiliation></author><author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name><affiliation><nlm:aff id="A4">Division of Biostatistics, Medical College of Wisconsin, Milwaukee, Wisconsin</nlm:aff></affiliation></author><author><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name><affiliation><nlm:aff id="A5">Department of Hematology/Oncology, Shands Healthcare, University of Florida, Gainesville, Florida</nlm:aff></affiliation></author><author><name sortKey="Arora, Mukta" sort="Arora, Mukta" uniqKey="Arora M" first="Mukta" last="Arora">Mukta Arora</name><affiliation><nlm:aff id="A6">Department of Hematology, Oncology and Transplant, University of Minnesota Medical Center, Minneapolis, Minnesota</nlm:aff></affiliation></author><author><name sortKey="George, Biju" sort="George, Biju" uniqKey="George B" first="Biju" last="George">Biju George</name><affiliation><nlm:aff id="A7">Department of Hematology, Christian Medical College Hospital, Vellore, Tamil Nadu, India</nlm:aff></affiliation></author><author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name><affiliation><nlm:aff id="A8">Vanderbilt University Medical Center, Brentwood, Tennessee</nlm:aff></affiliation></author><author><name sortKey="Bolwell, Brian" sort="Bolwell, Brian" uniqKey="Bolwell B" first="Brian" last="Bolwell">Brian Bolwell</name><affiliation><nlm:aff id="A9">Department of Bone Marrow Transplant, Cleveland Clinic, Cleveland, Ohio</nlm:aff></affiliation></author><author><name sortKey="Porter, David L" sort="Porter, David L" uniqKey="Porter D" first="David L." last="Porter">David L. Porter</name><affiliation><nlm:aff id="A10">Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania</nlm:aff></affiliation></author><author><name sortKey="Copelan, Ed" sort="Copelan, Ed" uniqKey="Copelan E" first="Ed" last="Copelan">Ed Copelan</name><affiliation><nlm:aff id="A9">Department of Bone Marrow Transplant, Cleveland Clinic, Cleveland, Ohio</nlm:aff></affiliation></author><author><name sortKey="Hale, Gregory" sort="Hale, Gregory" uniqKey="Hale G" first="Gregory" last="Hale">Gregory Hale</name><affiliation><nlm:aff id="A11">Department of Pediatric Hematology/Oncology/BMT, All Children’s Hospital, St. Petersburg, Florida</nlm:aff></affiliation></author><author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name><affiliation><nlm:aff id="A12">Interne Geneeskunde, Academische Ziekenhuis Maastricht, Maastricht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Lewis, Ian" sort="Lewis, Ian" uniqKey="Lewis I" first="Ian" last="Lewis">Ian Lewis</name><affiliation><nlm:aff id="A13">Haematology and Bone Marrow Transplant Unit, Royal Adelaïde Hôpital/South Australia Pathology, Adelaïde, South Australia</nlm:aff></affiliation></author><author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean Yves" last="Cahn">Jean Yves Cahn</name><affiliation><nlm:aff id="A14">Département d’Hématologie, Hôpital A. Michallon, CHU de Grenoble, Grenoble, France</nlm:aff></affiliation></author><author><name sortKey="Halter, Joerg" sort="Halter, Joerg" uniqKey="Halter J" first="Joerg" last="Halter">Joerg Halter</name><affiliation><nlm:aff id="A15">Department of Internal Medicine, University Hospital Basel, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Cortes, Jorge" sort="Cortes, Jorge" uniqKey="Cortes J" first="Jorge" last="Cortes">Jorge Cortes</name><affiliation><nlm:aff id="A16">MD Anderson Cancer Center, University of Texas, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Kalaycio, Matt E" sort="Kalaycio, Matt E" uniqKey="Kalaycio M" first="Matt E." last="Kalaycio">Matt E. Kalaycio</name><affiliation><nlm:aff id="A9">Department of Bone Marrow Transplant, Cleveland Clinic, Cleveland, Ohio</nlm:aff></affiliation></author><author><name sortKey="Antin, Joseph" sort="Antin, Joseph" uniqKey="Antin J" first="Joseph" last="Antin">Joseph Antin</name><affiliation><nlm:aff id="A17">Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name><affiliation><nlm:aff id="A18">Department of Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Carabasi, Matthew H" sort="Carabasi, Matthew H" uniqKey="Carabasi M" first="Matthew H." last="Carabasi">Matthew H. Carabasi</name><affiliation><nlm:aff id="A19">Department of Medical Oncology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania</nlm:aff></affiliation></author><author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name><affiliation><nlm:aff id="A20">Department of Hematology/Oncology, West Virginia University Hospitals, Inc., Morgantown, West Virginia</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Philip" sort="Mccarthy, Philip" uniqKey="Mccarthy P" first="Philip" last="Mccarthy">Philip Mccarthy</name><affiliation><nlm:aff id="A21">Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York</nlm:aff></affiliation></author><author><name sortKey="Pavletic, Steven" sort="Pavletic, Steven" uniqKey="Pavletic S" first="Steven" last="Pavletic">Steven Pavletic</name><affiliation><nlm:aff id="A22">Graft-vs-Host and Autoimmunity Unit, National Institutes of Health/National Cancer Institute, Bethesda, Maryland</nlm:aff></affiliation></author><author><name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name><affiliation><nlm:aff id="A23">Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Deeg, H Joachim" sort="Deeg, H Joachim" uniqKey="Deeg H" first="H. Joachim" last="Deeg">H. Joachim Deeg</name><affiliation><nlm:aff id="A2">Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Maziarz, Richard T" sort="Maziarz, Richard T" uniqKey="Maziarz R" first="Richard T." last="Maziarz">Richard T. Maziarz</name><affiliation><nlm:aff id="A24">Center for Hematologic Malignancies, Oregon Health and Science University, Portland, Oregon</nlm:aff></affiliation></author><author><name sortKey="Horowitz, Mary M" sort="Horowitz, Mary M" uniqKey="Horowitz M" first="Mary M." last="Horowitz">Mary M. Horowitz</name><affiliation><nlm:aff id="A3">Department of Medicine, Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, Wisconsin</nlm:aff></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation><nlm:aff id="A3">Department of Medicine, Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, Wisconsin</nlm:aff></affiliation></author></analytic><series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title><idno type="ISSN">1083-8791</idno><idno type="eISSN">1523-6536</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Allogeneic hematopoietic cell transplantation (HCT) is curative for selected patients with advanced essential thrombocythemia (ET) or polycythemia vera (PV). From 1990 to 2007, 75 patients with ET (median age 49 years) and 42 patients with PV (median age 53 years) underwent transplantations at the Fred Hutchinson Cancer Research Center (FHCRC; n = 43) or at other Center for International Blood and Marrow Transplant Research (CIBMTR) centers (n = 74). Thirty-eight percent of the patients had splenomegaly and 28% had a prior splenectomy. Most patients (69%for ET and 67%for PV) received a myeloablative (MA) conditioning regimen. Cumulative incidence of neutrophil engraftment at 28 days was 88% for ET patients and 90% for PV patients. Acute graft-versus- host disease (aGVHD) grades II to IV occurred in 57% and 50% of ET and PV patients, respectively. The 1-year treatment-related mortality (TRM) was 27% for ET and 22% for PV. The 5-year cumulative incidence of relapse was 13% for ET and 30% for PV. Five-year survival/progression-free survival (PFS) was 55%/47%and 71%/48% for ET and PV, respectively. Patients without splenomegaly had faster neutrophil and platelet engraftment, but there were no differences in TRM, survival, or PFS. Presence of myelofibrosis (MF) did not affect engraftment or TRM. Over 45% of the patients who undergo transplantations for ET and PV experience long-term PFS.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9600628</journal-id><journal-id journal-id-type="pubmed-jr-id">20830</journal-id><journal-id journal-id-type="nlm-ta">Biol Blood Marrow Transplant</journal-id><journal-id journal-id-type="iso-abbrev">Biol. Blood Marrow Transplant.</journal-id><journal-title-group><journal-title>Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</journal-title></journal-title-group><issn pub-type="ppub">1083-8791</issn><issn pub-type="epub">1523-6536</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22449610</article-id><article-id pub-id-type="pmc">3499973</article-id><article-id pub-id-type="doi">10.1016/j.bbmt.2012.03.009</article-id><article-id pub-id-type="manuscript">NIHMS406457</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Allogeneic Hematopoietic Cell Transplantation for Advanced Polycythemia Vera and Essential Thrombocythemia</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Ballen</surname><given-names>Karen K.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Woolfrey</surname><given-names>Ann E.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Zhu</surname><given-names>Xiaochun</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Ahn</surname><given-names>Kwang Woo</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Wirk</surname><given-names>Baldeep</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Arora</surname><given-names>Mukta</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>George</surname><given-names>Biju</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Savani</surname><given-names>Bipin N.</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Bolwell</surname><given-names>Brian</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Porter</surname><given-names>David L.</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Copelan</surname><given-names>Ed</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Hale</surname><given-names>Gregory</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Schouten</surname><given-names>Harry C.</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Lewis</surname><given-names>Ian</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Cahn</surname><given-names>Jean Yves</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Halter</surname><given-names>Joerg</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Cortes</surname><given-names>Jorge</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Kalaycio</surname><given-names>Matt E.</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Antin</surname><given-names>Joseph</given-names></name><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Aljurf</surname><given-names>Mahmoud D.</given-names></name><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Carabasi</surname><given-names>Matthew H.</given-names></name><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Hamadani</surname><given-names>Mehdi</given-names></name><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>McCarthy</surname><given-names>Philip</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Pavletic</surname><given-names>Steven</given-names></name><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Gupta</surname><given-names>Vikas</given-names></name><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Deeg</surname><given-names>H. Joachim</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Maziarz</surname><given-names>Richard T.</given-names></name><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Horowitz</surname><given-names>Mary M.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Saber</surname><given-names>Wael</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label>Division of Hematology/Oncology, Massachusetts General Hospital, Boston, Massachusetts</aff><aff id="A2"><label>2</label>Fred Hutchinson Cancer Research Center, Seattle, Washington</aff><aff id="A3"><label>3</label>Department of Medicine, Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, Wisconsin</aff><aff id="A4"><label>4</label>Division of Biostatistics, Medical College of Wisconsin, Milwaukee, Wisconsin</aff><aff id="A5"><label>5</label>Department of Hematology/Oncology, Shands Healthcare, University of Florida, Gainesville, Florida</aff><aff id="A6"><label>6</label>Department of Hematology, Oncology and Transplant, University of Minnesota Medical Center, Minneapolis, Minnesota</aff><aff id="A7"><label>7</label>Department of Hematology, Christian Medical College Hospital, Vellore, Tamil Nadu, India</aff><aff id="A8"><label>8</label>Vanderbilt University Medical Center, Brentwood, Tennessee</aff><aff id="A9"><label>9</label>Department of Bone Marrow Transplant, Cleveland Clinic, Cleveland, Ohio</aff><aff id="A10"><label>10</label>Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania</aff><aff id="A11"><label>11</label>Department of Pediatric Hematology/Oncology/BMT, All Children’s Hospital, St. Petersburg, Florida</aff><aff id="A12"><label>12</label>Interne Geneeskunde, Academische Ziekenhuis Maastricht, Maastricht, The Netherlands</aff><aff id="A13"><label>13</label>Haematology and Bone Marrow Transplant Unit, Royal Adelaïde Hôpital/South Australia Pathology, Adelaïde, South Australia</aff><aff id="A14"><label>14</label>Département d’Hématologie, Hôpital A. Michallon, CHU de Grenoble, Grenoble, France</aff><aff id="A15"><label>15</label>Department of Internal Medicine, University Hospital Basel, Basel, Switzerland</aff><aff id="A16"><label>16</label>MD Anderson Cancer Center, University of Texas, Houston, Texas</aff><aff id="A17"><label>17</label>Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts</aff><aff id="A18"><label>18</label>Department of Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia</aff><aff id="A19"><label>19</label>Department of Medical Oncology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania</aff><aff id="A20"><label>20</label>Department of Hematology/Oncology, West Virginia University Hospitals, Inc., Morgantown, West Virginia</aff><aff id="A21"><label>21</label>Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York</aff><aff id="A22"><label>22</label>Graft-vs-Host and Autoimmunity Unit, National Institutes of Health/National Cancer Institute, Bethesda, Maryland</aff><aff id="A23"><label>23</label>Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada</aff><aff id="A24"><label>24</label>Center for Hematologic Malignancies, Oregon Health and Science University, Portland, Oregon</aff><author-notes><corresp id="FN1">Correspondence and reprint requests: Karen K. Ballen, MD, Division of Hematology/Oncology, Massachusetts General Hospital, Zero Emerson, Suite 118, Boston, MA 02214 (<email>kballen@partners.org</email>)</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>21</day><month>9</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>24</day><month>3</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>9</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>9</month><year>2013</year></pub-date><volume>18</volume><issue>9</issue><fpage>1446</fpage><lpage>1454</lpage><permissions><copyright-statement>© 2012 American Society for Blood and Marrow Transplantation</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract><p id="P1">Allogeneic hematopoietic cell transplantation (HCT) is curative for selected patients with advanced essential thrombocythemia (ET) or polycythemia vera (PV). From 1990 to 2007, 75 patients with ET (median age 49 years) and 42 patients with PV (median age 53 years) underwent transplantations at the Fred Hutchinson Cancer Research Center (FHCRC; n = 43) or at other Center for International Blood and Marrow Transplant Research (CIBMTR) centers (n = 74). Thirty-eight percent of the patients had splenomegaly and 28% had a prior splenectomy. Most patients (69%for ET and 67%for PV) received a myeloablative (MA) conditioning regimen. Cumulative incidence of neutrophil engraftment at 28 days was 88% for ET patients and 90% for PV patients. Acute graft-versus- host disease (aGVHD) grades II to IV occurred in 57% and 50% of ET and PV patients, respectively. The 1-year treatment-related mortality (TRM) was 27% for ET and 22% for PV. The 5-year cumulative incidence of relapse was 13% for ET and 30% for PV. Five-year survival/progression-free survival (PFS) was 55%/47%and 71%/48% for ET and PV, respectively. Patients without splenomegaly had faster neutrophil and platelet engraftment, but there were no differences in TRM, survival, or PFS. Presence of myelofibrosis (MF) did not affect engraftment or TRM. Over 45% of the patients who undergo transplantations for ET and PV experience long-term PFS.</p></abstract><kwd-group><kwd>Transplantation</kwd><kwd>PV</kwd><kwd>ET</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>U24 CA076518 || CA</award-id></award-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>U01 HL069294 || HL</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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