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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Gait phenotype from MCI to moderate dementia: results from the GOOD initiative</title><author><name sortKey="Allali, Gilles" sort="Allali, Gilles" uniqKey="Allali G" first="Gilles" last="Allali">Gilles Allali</name><affiliation><nlm:aff id="A1">Department of Neurology, Division of Cognitive & Motor Aging, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Neurology, Geneva University Hospital and University of Geneva, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Annweiler, Cedric" sort="Annweiler, Cedric" uniqKey="Annweiler C" first="Cédric" last="Annweiler">Cédric Annweiler</name><affiliation><nlm:aff id="A3">Department of Neuroscience, Division of Geriatric Medicine, UPRES EA 4638, UNAM, Angers University Hospital, Angers, France</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Center for Functional and Metabolic Mapping, Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Blumen, Helena M" sort="Blumen, Helena M" uniqKey="Blumen H" first="Helena M." last="Blumen">Helena M. Blumen</name><affiliation><nlm:aff id="A1">Department of Neurology, Division of Cognitive & Motor Aging, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Callisaya, Michele L" sort="Callisaya, Michele L" uniqKey="Callisaya M" first="Michele L." last="Callisaya">Michele L. Callisaya</name><affiliation><nlm:aff id="A5">Menzies Institute of Medical Research, University of Tasmania, Tasmania, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Stroke and Ageing Research Group, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="De Cock, Anne Marie" sort="De Cock, Anne Marie" uniqKey="De Cock A" first="Anne-Marie" last="De Cock">Anne-Marie De Cock</name><affiliation><nlm:aff id="A7">Department of Geriatric Medicine, AZ ST Maarten Mechelen, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Department of Geriatrics, University of Antwerp, Antwerp, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Department of Primary an Interdisciplinary Care (ELIZA), University of Antwerp, Antwerp, Belgium</nlm:aff></affiliation></author><author><name sortKey="Kressig, Reto W" sort="Kressig, Reto W" uniqKey="Kressig R" first="Reto W." last="Kressig">Reto W. Kressig</name><affiliation><nlm:aff id="A10">University Center for Medicine of Aging, Felix Platter Hospital and University of Basel, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Srikanth, Velandai" sort="Srikanth, Velandai" uniqKey="Srikanth V" first="Velandai" last="Srikanth">Velandai Srikanth</name><affiliation><nlm:aff id="A5">Menzies Institute of Medical Research, University of Tasmania, Tasmania, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Stroke and Ageing Research Group, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Steinmetz, Jean Paul" sort="Steinmetz, Jean Paul" uniqKey="Steinmetz J" first="Jean-Paul" last="Steinmetz">Jean-Paul Steinmetz</name><affiliation><nlm:aff id="A11">Centre for Memory and Mobility (CeM<sup>2</sup>), Luxembourg-city, Luxembourg</nlm:aff></affiliation></author><author><name sortKey="Verghese, Joe" sort="Verghese, Joe" uniqKey="Verghese J" first="Joe" last="Verghese">Joe Verghese</name><affiliation><nlm:aff id="A1">Department of Neurology, Division of Cognitive & Motor Aging, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Beauchet, Olivier" sort="Beauchet, Olivier" uniqKey="Beauchet O" first="Olivier" last="Beauchet">Olivier Beauchet</name><affiliation><nlm:aff id="A3">Department of Neuroscience, Division of Geriatric Medicine, UPRES EA 4638, UNAM, Angers University Hospital, Angers, France</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Department of Medicine, Division of Geriatric Medicine, Jewish General Hospital, McGill University, Montréal, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Biomathics, Paris, France</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26662508</idno><idno type="pmc">4769662</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769662</idno><idno type="RBID">PMC:4769662</idno><idno type="doi">10.1111/ene.12882</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002183</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002183</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Gait phenotype from MCI to moderate dementia: results from the GOOD initiative</title><author><name sortKey="Allali, Gilles" sort="Allali, Gilles" uniqKey="Allali G" first="Gilles" last="Allali">Gilles Allali</name><affiliation><nlm:aff id="A1">Department of Neurology, Division of Cognitive & Motor Aging, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Neurology, Geneva University Hospital and University of Geneva, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Annweiler, Cedric" sort="Annweiler, Cedric" uniqKey="Annweiler C" first="Cédric" last="Annweiler">Cédric Annweiler</name><affiliation><nlm:aff id="A3">Department of Neuroscience, Division of Geriatric Medicine, UPRES EA 4638, UNAM, Angers University Hospital, Angers, France</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Center for Functional and Metabolic Mapping, Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Blumen, Helena M" sort="Blumen, Helena M" uniqKey="Blumen H" first="Helena M." last="Blumen">Helena M. Blumen</name><affiliation><nlm:aff id="A1">Department of Neurology, Division of Cognitive & Motor Aging, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Callisaya, Michele L" sort="Callisaya, Michele L" uniqKey="Callisaya M" first="Michele L." last="Callisaya">Michele L. Callisaya</name><affiliation><nlm:aff id="A5">Menzies Institute of Medical Research, University of Tasmania, Tasmania, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Stroke and Ageing Research Group, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="De Cock, Anne Marie" sort="De Cock, Anne Marie" uniqKey="De Cock A" first="Anne-Marie" last="De Cock">Anne-Marie De Cock</name><affiliation><nlm:aff id="A7">Department of Geriatric Medicine, AZ ST Maarten Mechelen, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Department of Geriatrics, University of Antwerp, Antwerp, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Department of Primary an Interdisciplinary Care (ELIZA), University of Antwerp, Antwerp, Belgium</nlm:aff></affiliation></author><author><name sortKey="Kressig, Reto W" sort="Kressig, Reto W" uniqKey="Kressig R" first="Reto W." last="Kressig">Reto W. Kressig</name><affiliation><nlm:aff id="A10">University Center for Medicine of Aging, Felix Platter Hospital and University of Basel, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Srikanth, Velandai" sort="Srikanth, Velandai" uniqKey="Srikanth V" first="Velandai" last="Srikanth">Velandai Srikanth</name><affiliation><nlm:aff id="A5">Menzies Institute of Medical Research, University of Tasmania, Tasmania, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Stroke and Ageing Research Group, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Steinmetz, Jean Paul" sort="Steinmetz, Jean Paul" uniqKey="Steinmetz J" first="Jean-Paul" last="Steinmetz">Jean-Paul Steinmetz</name><affiliation><nlm:aff id="A11">Centre for Memory and Mobility (CeM<sup>2</sup>), Luxembourg-city, Luxembourg</nlm:aff></affiliation></author><author><name sortKey="Verghese, Joe" sort="Verghese, Joe" uniqKey="Verghese J" first="Joe" last="Verghese">Joe Verghese</name><affiliation><nlm:aff id="A1">Department of Neurology, Division of Cognitive & Motor Aging, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Beauchet, Olivier" sort="Beauchet, Olivier" uniqKey="Beauchet O" first="Olivier" last="Beauchet">Olivier Beauchet</name><affiliation><nlm:aff id="A3">Department of Neuroscience, Division of Geriatric Medicine, UPRES EA 4638, UNAM, Angers University Hospital, Angers, France</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Department of Medicine, Division of Geriatric Medicine, Jewish General Hospital, McGill University, Montréal, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Biomathics, Paris, France</nlm:aff></affiliation></author></analytic><series><title level="j">European journal of neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">The differences in gait abnormalities from the earliest to the latter stages of dementia and in the different subtypes of dementia have not been fully examined. This study aims to compare spatio-temporal gait parameters in cognitively healthy individuals, patients with amnestic (aMCI) and non-amnestic (naMCI) MCI, and patients with mild and moderate stages of Alzheimer’s disease (AD) and non-Alzheimer’s disease (non-AD).</p></sec><sec id="S2"><title>Methods</title><p id="P2">Based on a cross-sectional design, 1719 participants (77.4±7.3 years, 53.9% female) were recruited from cohorts from seven countries participating in the “Gait, cOgnitiOn & Decline” initiative. Mean values and coefficients of variation of spatio-temporal gait parameters were measured during normal pace walking with the GAITRite system at all sites.</p></sec><sec id="S3"><title>Results</title><p id="P3">Performance of spatio-temporal gait parameters declined in parallel to the stage of cognitive decline from MCI status to moderate dementia. Gait parameters of patients with naMCI were more disturbed compared to patients with aMCI, and MCI subgroups performed better than demented patients. Patients with non-AD dementia had worse gait performance than those with AD dementia. This degradation of the gait parameters was similar between mean values and coefficients of variation of spatio-temporal gait parameters in the earliest stages of cognitive decline, but different in the most advanced stages, especially in the non-AD subtypes.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Spatio-temporal gait parameters were more disturbed in the advanced stages of dementia, and more affected in the non-AD dementias than in AD. These findings suggest that quantitative gait parameters could be used as a surrogate marker for improving the diagnosis of dementia.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9506311</journal-id><journal-id journal-id-type="pubmed-jr-id">20870</journal-id><journal-id journal-id-type="nlm-ta">Eur J Neurol</journal-id><journal-id journal-id-type="iso-abbrev">Eur. J. Neurol.</journal-id><journal-title-group><journal-title>European journal of neurology</journal-title></journal-title-group><issn pub-type="ppub">1351-5101</issn><issn pub-type="epub">1468-1331</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26662508</article-id><article-id pub-id-type="pmc">4769662</article-id><article-id pub-id-type="doi">10.1111/ene.12882</article-id><article-id pub-id-type="manuscript">NIHMS719445</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Gait phenotype from MCI to moderate dementia: results from the GOOD initiative</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Allali</surname><given-names>Gilles</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Annweiler</surname><given-names>Cédric</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Blumen</surname><given-names>Helena M.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Callisaya</surname><given-names>Michele L.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>De Cock</surname><given-names>Anne-Marie</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Kressig</surname><given-names>Reto W.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Srikanth</surname><given-names>Velandai</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Steinmetz</surname><given-names>Jean-Paul</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Verghese</surname><given-names>Joe</given-names></name><degrees>MBBS</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Beauchet</surname><given-names>Olivier</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A12">12</xref><xref ref-type="aff" rid="A13">13</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Neurology, Division of Cognitive & Motor Aging, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, USA</aff><aff id="A2"><label>2</label>Department of Neurology, Geneva University Hospital and University of Geneva, Switzerland</aff><aff id="A3"><label>3</label>Department of Neuroscience, Division of Geriatric Medicine, UPRES EA 4638, UNAM, Angers University Hospital, Angers, France</aff><aff id="A4"><label>4</label>Center for Functional and Metabolic Mapping, Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, Ontario, Canada</aff><aff id="A5"><label>5</label>Menzies Institute of Medical Research, University of Tasmania, Tasmania, Australia</aff><aff id="A6"><label>6</label>Stroke and Ageing Research Group, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Victoria, Australia</aff><aff id="A7"><label>7</label>Department of Geriatric Medicine, AZ ST Maarten Mechelen, Belgium</aff><aff id="A8"><label>8</label>Department of Geriatrics, University of Antwerp, Antwerp, Belgium</aff><aff id="A9"><label>9</label>Department of Primary an Interdisciplinary Care (ELIZA), University of Antwerp, Antwerp, Belgium</aff><aff id="A10"><label>10</label>University Center for Medicine of Aging, Felix Platter Hospital and University of Basel, Basel, Switzerland</aff><aff id="A11"><label>11</label>Centre for Memory and Mobility (CeM<sup>2</sup>), Luxembourg-city, Luxembourg</aff><aff id="A12"><label>12</label>Department of Medicine, Division of Geriatric Medicine, Jewish General Hospital, McGill University, Montréal, Canada</aff><aff id="A13"><label>13</label>Biomathics, Paris, France</aff><author-notes><corresp id="FN1">Correspondence to: Gilles Allali, Albert Einstein College of Medicine, Yeshiva University, 1165 Morris Park Avenue, Room 420, Bronx, New York 10461; T#: +1-718-430-3991; F#: +1-718-430-3829; <email>gilles.allali@einstein.yu.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>4</day><month>9</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>14</day><month>12</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>3</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>3</month><year>2017</year></pub-date><volume>23</volume><issue>3</issue><fpage>527</fpage><lpage>541</lpage><pmc-comment>elocation-id from pubmed: 10.1111/ene.12882</pmc-comment>
<abstract><sec id="S1"><title>Background</title><p id="P1">The differences in gait abnormalities from the earliest to the latter stages of dementia and in the different subtypes of dementia have not been fully examined. This study aims to compare spatio-temporal gait parameters in cognitively healthy individuals, patients with amnestic (aMCI) and non-amnestic (naMCI) MCI, and patients with mild and moderate stages of Alzheimer’s disease (AD) and non-Alzheimer’s disease (non-AD).</p></sec><sec id="S2"><title>Methods</title><p id="P2">Based on a cross-sectional design, 1719 participants (77.4±7.3 years, 53.9% female) were recruited from cohorts from seven countries participating in the “Gait, cOgnitiOn & Decline” initiative. Mean values and coefficients of variation of spatio-temporal gait parameters were measured during normal pace walking with the GAITRite system at all sites.</p></sec><sec id="S3"><title>Results</title><p id="P3">Performance of spatio-temporal gait parameters declined in parallel to the stage of cognitive decline from MCI status to moderate dementia. Gait parameters of patients with naMCI were more disturbed compared to patients with aMCI, and MCI subgroups performed better than demented patients. Patients with non-AD dementia had worse gait performance than those with AD dementia. This degradation of the gait parameters was similar between mean values and coefficients of variation of spatio-temporal gait parameters in the earliest stages of cognitive decline, but different in the most advanced stages, especially in the non-AD subtypes.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Spatio-temporal gait parameters were more disturbed in the advanced stages of dementia, and more affected in the non-AD dementias than in AD. These findings suggest that quantitative gait parameters could be used as a surrogate marker for improving the diagnosis of dementia.</p></sec></abstract><kwd-group><kwd>Dementia</kwd><kwd>mild cognitive impairment</kwd><kwd>aging</kwd><kwd>Alzheimer’s disease</kwd><kwd>gait disorders</kwd><kwd>quantitative gait parameters</kwd><kwd>motor control</kwd><kwd>cohort studies</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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