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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A prospective evaluation of early detection biomarkers for ovarian cancer in the European EPIC cohort</title><author><name sortKey="Terry, Kathryn L" sort="Terry, Kathryn L" uniqKey="Terry K" first="Kathryn L." last="Terry">Kathryn L. Terry</name><affiliation><nlm:aff id="A1"> Ob/Gyn Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Schock, Helena" sort="Schock, Helena" uniqKey="Schock H" first="Helena" last="Schock">Helena Schock</name><affiliation><nlm:aff id="A3"> Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Fortner, Renee T" sort="Fortner, Renee T" uniqKey="Fortner R" first="Renée T." last="Fortner">Renée T. Fortner</name><affiliation><nlm:aff id="A3"> Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Husing, Anika" sort="Husing, Anika" uniqKey="Husing A" first="Anika" last="Hüsing">Anika Hüsing</name><affiliation><nlm:aff id="A3"> Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Fichorova, Raina N" sort="Fichorova, Raina N" uniqKey="Fichorova R" first="Raina N." last="Fichorova">Raina N. Fichorova</name><affiliation><nlm:aff id="A2"> Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4"> Genital Tract Biology Laboratory, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Yamamoto, Hidemi S" sort="Yamamoto, Hidemi S" uniqKey="Yamamoto H" first="Hidemi S." last="Yamamoto">Hidemi S. Yamamoto</name><affiliation><nlm:aff id="A2"> Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4"> Genital Tract Biology Laboratory, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Vitonis, Allison F" sort="Vitonis, Allison F" uniqKey="Vitonis A" first="Allison F." last="Vitonis">Allison F. Vitonis</name><affiliation><nlm:aff id="A1"> Ob/Gyn Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Johnson, Theron" sort="Johnson, Theron" uniqKey="Johnson T" first="Theron" last="Johnson">Theron Johnson</name><affiliation><nlm:aff id="A3"> Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name><affiliation><nlm:aff id="A5"> Department of Epidemiology, Aarhus University, Aarhus, Denmark</nlm:aff></affiliation></author><author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name><affiliation><nlm:aff id="A6"> Danish Cancer Society Research Center, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><affiliation><nlm:aff id="A7"> Université Paris-Sud, Centre de recherche en Épidémiologie et Santé des Populations (CESP), Institut Nationale de Santë et de Recherche Médicale (INSERM), Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8"> Gustave Roussy, F-94805, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Mesrine, Sylvie" sort="Mesrine, Sylvie" uniqKey="Mesrine S" first="Sylvie" last="Mesrine">Sylvie Mesrine</name><affiliation><nlm:aff id="A7"> Université Paris-Sud, Centre de recherche en Épidémiologie et Santé des Populations (CESP), Institut Nationale de Santë et de Recherche Médicale (INSERM), Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8"> Gustave Roussy, F-94805, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="A7"> Université Paris-Sud, Centre de recherche en Épidémiologie et Santé des Populations (CESP), Institut Nationale de Santë et de Recherche Médicale (INSERM), Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8"> Gustave Roussy, F-94805, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A9"> Human Genetics Foundation (HuGeF), Torino, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A10"> Cancer Council Victoria and University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Dossus, Laure" sort="Dossus, Laure" uniqKey="Dossus L" first="Laure" last="Dossus">Laure Dossus</name><affiliation><nlm:aff id="A11"> International Agency for Research on Cancer, Lyon, France, Nutrition and Metabolism section</nlm:aff></affiliation></author><author><name sortKey="Rinaldi, Sabina" sort="Rinaldi, Sabina" uniqKey="Rinaldi S" first="Sabina" last="Rinaldi">Sabina Rinaldi</name><affiliation><nlm:aff id="A11"> International Agency for Research on Cancer, Lyon, France, Nutrition and Metabolism section</nlm:aff></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation><nlm:aff id="A12"> Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany</nlm:aff></affiliation></author><author><name sortKey="Benetou, Vassiliki" sort="Benetou, Vassiliki" uniqKey="Benetou V" first="Vassiliki" last="Benetou">Vassiliki Benetou</name><affiliation><nlm:aff id="A13"> Helenic Health Foundation Athens, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A14"> WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Greece</nlm:aff></affiliation></author><author><name sortKey="Lagiou, Pagona" sort="Lagiou, Pagona" uniqKey="Lagiou P" first="Pagona" last="Lagiou">Pagona Lagiou</name><affiliation><nlm:aff id="A13"> Helenic Health Foundation Athens, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A14"> WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Greece</nlm:aff></affiliation></author><author><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name><affiliation><nlm:aff id="A13"> Helenic Health Foundation Athens, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A14"> WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Greece</nlm:aff></affiliation></author><author><name sortKey="Krogh, Vittorio" sort="Krogh, Vittorio" uniqKey="Krogh V" first="Vittorio" last="Krogh">Vittorio Krogh</name><affiliation><nlm:aff id="A15"> Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Kuhn, Elisabetta" sort="Kuhn, Elisabetta" uniqKey="Kuhn E" first="Elisabetta" last="Kuhn">Elisabetta Kuhn</name><affiliation><nlm:aff id="A16"> Department of Morphology, Surgery and Experimental Medicine and Laboratorio per le Tecnologie delle Terapie Avanzate (LTTA) Centre, University of Ferrara, Ferrara, Italy</nlm:aff></affiliation></author><author><name sortKey="Panico, Salvatore" sort="Panico, Salvatore" uniqKey="Panico S" first="Salvatore" last="Panico">Salvatore Panico</name><affiliation><nlm:aff id="A17"> Dipartimento di Medicina Clinical e Chirurgia, Federico II University, Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H. Bas" last="Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name><affiliation><nlm:aff id="A18"> National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N. Charlotte" last="Onland-Moret">N. Charlotte Onland-Moret</name><affiliation><nlm:aff id="A19"> Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name><affiliation><nlm:aff id="A19"> Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Gram, Inger Torhild" sort="Gram, Inger Torhild" uniqKey="Gram I" first="Inger Torhild" last="Gram">Inger Torhild Gram</name><affiliation><nlm:aff id="A20"> Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway</nlm:aff></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation><nlm:aff id="A20"> Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A21"> Department of Research, Cancer Registry of Norway, Institute of Population-Based Case Research, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A22"> Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A23"> Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Duell, Eric J" sort="Duell, Eric J" uniqKey="Duell E" first="Eric J." last="Duell">Eric J. Duell</name><affiliation><nlm:aff id="A24"> Unit of Nutrition and Cancer Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute, Catalan Institute of Oncology, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="Maria-Jose" last="Sanchez">Maria-Jose Sanchez</name><affiliation><nlm:aff id="A25"> Escuela Andaluza de Salud Publica, Instituto de Investigación Bionsanitaria ibs. Granada, Hospitales Universitarios de Granada, Granada, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A26"> Centro de Investigación Biomédica En Red (CIBER) , Section Epidemiology and Public Health (CIBERESP), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Ardanaz, Eva" sort="Ardanaz, Eva" uniqKey="Ardanaz E" first="Eva" last="Ardanaz">Eva Ardanaz</name><affiliation><nlm:aff id="A26"> Centro de Investigación Biomédica En Red (CIBER) , Section Epidemiology and Public Health (CIBERESP), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A27"> Navarra Public Health Institute, Pamplona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A28"> IdiSNA, Navarra Institute for Health Research, Pamplona, Spain</nlm:aff></affiliation></author><author><name sortKey="Etxezarreta, Nerea" sort="Etxezarreta, Nerea" uniqKey="Etxezarreta N" first="Nerea" last="Etxezarreta">Nerea Etxezarreta</name><affiliation><nlm:aff id="A26"> Centro de Investigación Biomédica En Red (CIBER) , Section Epidemiology and Public Health (CIBERESP), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A29"> Public Health Division of Gipuzkoa, Regional Government of the Basque Country, Spain</nlm:aff></affiliation></author><author><name sortKey="Navarro, Carmen" sort="Navarro, Carmen" uniqKey="Navarro C" first="Carmen" last="Navarro">Carmen Navarro</name><affiliation><nlm:aff id="A26"> Centro de Investigación Biomédica En Red (CIBER) , Section Epidemiology and Public Health (CIBERESP), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A30"> Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A31"> Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain</nlm:aff></affiliation></author><author><name sortKey="Idahl, Annika" sort="Idahl, Annika" uniqKey="Idahl A" first="Annika" last="Idahl">Annika Idahl</name><affiliation><nlm:aff id="A32"> Department of Clinical Sciences, Obstetrics and Gynecology Umeå, University of Umeå, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lundin, Eva" sort="Lundin, Eva" uniqKey="Lundin E" first="Eva" last="Lundin">Eva Lundin</name><affiliation><nlm:aff id="A33"> Department of Medical Biosciences, Pathology Umeå, University of Umeå, Sweden</nlm:aff></affiliation></author><author><name sortKey="Jirstrom, Karin" sort="Jirstrom, Karin" uniqKey="Jirstrom K" first="Karin" last="Jirström">Karin Jirström</name><affiliation><nlm:aff id="A34"> Department of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A35"> Department of Surgery, Skåne University Hospital, Lund University, Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Manjer, Jonas" sort="Manjer, Jonas" uniqKey="Manjer J" first="Jonas" last="Manjer">Jonas Manjer</name><affiliation><nlm:aff id="A34"> Department of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A35"> Department of Surgery, Skåne University Hospital, Lund University, Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A36"> Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:aff id="A37"> University of Cambridge School of Clinical Medicine, Clinical Gerontology, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Byrne, Karl Smith" sort="Byrne, Karl Smith" uniqKey="Byrne K" first="Karl Smith" last="Byrne">Karl Smith Byrne</name><affiliation><nlm:aff id="A38"> Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation><nlm:aff id="A38"> Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J." last="Gunter">Marc J. Gunter</name><affiliation><nlm:aff id="A39"> Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Merritt, Melissa A" sort="Merritt, Melissa A" uniqKey="Merritt M" first="Melissa A." last="Merritt">Melissa A. Merritt</name><affiliation><nlm:aff id="A39"> Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation><nlm:aff id="A39"> Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Cramer, Daniel W" sort="Cramer, Daniel W" uniqKey="Cramer D" first="Daniel W." last="Cramer">Daniel W. Cramer</name><affiliation><nlm:aff id="A1"> Ob/Gyn Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation><nlm:aff id="A2"> Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27060155</idno><idno type="pmc">5026545</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026545</idno><idno type="RBID">PMC:5026545</idno><idno type="doi">10.1158/1078-0432.CCR-16-0316</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002179</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002179</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A prospective evaluation of early detection biomarkers for ovarian cancer in the European EPIC cohort</title><author><name sortKey="Terry, Kathryn L" sort="Terry, Kathryn L" uniqKey="Terry K" first="Kathryn L." last="Terry">Kathryn L. Terry</name><affiliation><nlm:aff id="A1"> Ob/Gyn Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Schock, Helena" sort="Schock, Helena" uniqKey="Schock H" first="Helena" last="Schock">Helena Schock</name><affiliation><nlm:aff id="A3"> Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Fortner, Renee T" sort="Fortner, Renee T" uniqKey="Fortner R" first="Renée T." last="Fortner">Renée T. Fortner</name><affiliation><nlm:aff id="A3"> Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Husing, Anika" sort="Husing, Anika" uniqKey="Husing A" first="Anika" last="Hüsing">Anika Hüsing</name><affiliation><nlm:aff id="A3"> Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Fichorova, Raina N" sort="Fichorova, Raina N" uniqKey="Fichorova R" first="Raina N." last="Fichorova">Raina N. Fichorova</name><affiliation><nlm:aff id="A2"> Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4"> Genital Tract Biology Laboratory, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Yamamoto, Hidemi S" sort="Yamamoto, Hidemi S" uniqKey="Yamamoto H" first="Hidemi S." last="Yamamoto">Hidemi S. Yamamoto</name><affiliation><nlm:aff id="A2"> Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4"> Genital Tract Biology Laboratory, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Vitonis, Allison F" sort="Vitonis, Allison F" uniqKey="Vitonis A" first="Allison F." last="Vitonis">Allison F. Vitonis</name><affiliation><nlm:aff id="A1"> Ob/Gyn Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Johnson, Theron" sort="Johnson, Theron" uniqKey="Johnson T" first="Theron" last="Johnson">Theron Johnson</name><affiliation><nlm:aff id="A3"> Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name><affiliation><nlm:aff id="A5"> Department of Epidemiology, Aarhus University, Aarhus, Denmark</nlm:aff></affiliation></author><author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name><affiliation><nlm:aff id="A6"> Danish Cancer Society Research Center, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><affiliation><nlm:aff id="A7"> Université Paris-Sud, Centre de recherche en Épidémiologie et Santé des Populations (CESP), Institut Nationale de Santë et de Recherche Médicale (INSERM), Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8"> Gustave Roussy, F-94805, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Mesrine, Sylvie" sort="Mesrine, Sylvie" uniqKey="Mesrine S" first="Sylvie" last="Mesrine">Sylvie Mesrine</name><affiliation><nlm:aff id="A7"> Université Paris-Sud, Centre de recherche en Épidémiologie et Santé des Populations (CESP), Institut Nationale de Santë et de Recherche Médicale (INSERM), Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8"> Gustave Roussy, F-94805, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="A7"> Université Paris-Sud, Centre de recherche en Épidémiologie et Santé des Populations (CESP), Institut Nationale de Santë et de Recherche Médicale (INSERM), Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8"> Gustave Roussy, F-94805, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A9"> Human Genetics Foundation (HuGeF), Torino, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A10"> Cancer Council Victoria and University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Dossus, Laure" sort="Dossus, Laure" uniqKey="Dossus L" first="Laure" last="Dossus">Laure Dossus</name><affiliation><nlm:aff id="A11"> International Agency for Research on Cancer, Lyon, France, Nutrition and Metabolism section</nlm:aff></affiliation></author><author><name sortKey="Rinaldi, Sabina" sort="Rinaldi, Sabina" uniqKey="Rinaldi S" first="Sabina" last="Rinaldi">Sabina Rinaldi</name><affiliation><nlm:aff id="A11"> International Agency for Research on Cancer, Lyon, France, Nutrition and Metabolism section</nlm:aff></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation><nlm:aff id="A12"> Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany</nlm:aff></affiliation></author><author><name sortKey="Benetou, Vassiliki" sort="Benetou, Vassiliki" uniqKey="Benetou V" first="Vassiliki" last="Benetou">Vassiliki Benetou</name><affiliation><nlm:aff id="A13"> Helenic Health Foundation Athens, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A14"> WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Greece</nlm:aff></affiliation></author><author><name sortKey="Lagiou, Pagona" sort="Lagiou, Pagona" uniqKey="Lagiou P" first="Pagona" last="Lagiou">Pagona Lagiou</name><affiliation><nlm:aff id="A13"> Helenic Health Foundation Athens, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A14"> WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Greece</nlm:aff></affiliation></author><author><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name><affiliation><nlm:aff id="A13"> Helenic Health Foundation Athens, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A14"> WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Greece</nlm:aff></affiliation></author><author><name sortKey="Krogh, Vittorio" sort="Krogh, Vittorio" uniqKey="Krogh V" first="Vittorio" last="Krogh">Vittorio Krogh</name><affiliation><nlm:aff id="A15"> Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Kuhn, Elisabetta" sort="Kuhn, Elisabetta" uniqKey="Kuhn E" first="Elisabetta" last="Kuhn">Elisabetta Kuhn</name><affiliation><nlm:aff id="A16"> Department of Morphology, Surgery and Experimental Medicine and Laboratorio per le Tecnologie delle Terapie Avanzate (LTTA) Centre, University of Ferrara, Ferrara, Italy</nlm:aff></affiliation></author><author><name sortKey="Panico, Salvatore" sort="Panico, Salvatore" uniqKey="Panico S" first="Salvatore" last="Panico">Salvatore Panico</name><affiliation><nlm:aff id="A17"> Dipartimento di Medicina Clinical e Chirurgia, Federico II University, Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H. Bas" last="Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name><affiliation><nlm:aff id="A18"> National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N. Charlotte" last="Onland-Moret">N. Charlotte Onland-Moret</name><affiliation><nlm:aff id="A19"> Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name><affiliation><nlm:aff id="A19"> Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Gram, Inger Torhild" sort="Gram, Inger Torhild" uniqKey="Gram I" first="Inger Torhild" last="Gram">Inger Torhild Gram</name><affiliation><nlm:aff id="A20"> Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway</nlm:aff></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation><nlm:aff id="A20"> Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A21"> Department of Research, Cancer Registry of Norway, Institute of Population-Based Case Research, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A22"> Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A23"> Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Duell, Eric J" sort="Duell, Eric J" uniqKey="Duell E" first="Eric J." last="Duell">Eric J. Duell</name><affiliation><nlm:aff id="A24"> Unit of Nutrition and Cancer Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute, Catalan Institute of Oncology, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="Maria-Jose" last="Sanchez">Maria-Jose Sanchez</name><affiliation><nlm:aff id="A25"> Escuela Andaluza de Salud Publica, Instituto de Investigación Bionsanitaria ibs. Granada, Hospitales Universitarios de Granada, Granada, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A26"> Centro de Investigación Biomédica En Red (CIBER) , Section Epidemiology and Public Health (CIBERESP), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Ardanaz, Eva" sort="Ardanaz, Eva" uniqKey="Ardanaz E" first="Eva" last="Ardanaz">Eva Ardanaz</name><affiliation><nlm:aff id="A26"> Centro de Investigación Biomédica En Red (CIBER) , Section Epidemiology and Public Health (CIBERESP), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A27"> Navarra Public Health Institute, Pamplona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A28"> IdiSNA, Navarra Institute for Health Research, Pamplona, Spain</nlm:aff></affiliation></author><author><name sortKey="Etxezarreta, Nerea" sort="Etxezarreta, Nerea" uniqKey="Etxezarreta N" first="Nerea" last="Etxezarreta">Nerea Etxezarreta</name><affiliation><nlm:aff id="A26"> Centro de Investigación Biomédica En Red (CIBER) , Section Epidemiology and Public Health (CIBERESP), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A29"> Public Health Division of Gipuzkoa, Regional Government of the Basque Country, Spain</nlm:aff></affiliation></author><author><name sortKey="Navarro, Carmen" sort="Navarro, Carmen" uniqKey="Navarro C" first="Carmen" last="Navarro">Carmen Navarro</name><affiliation><nlm:aff id="A26"> Centro de Investigación Biomédica En Red (CIBER) , Section Epidemiology and Public Health (CIBERESP), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A30"> Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A31"> Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain</nlm:aff></affiliation></author><author><name sortKey="Idahl, Annika" sort="Idahl, Annika" uniqKey="Idahl A" first="Annika" last="Idahl">Annika Idahl</name><affiliation><nlm:aff id="A32"> Department of Clinical Sciences, Obstetrics and Gynecology Umeå, University of Umeå, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lundin, Eva" sort="Lundin, Eva" uniqKey="Lundin E" first="Eva" last="Lundin">Eva Lundin</name><affiliation><nlm:aff id="A33"> Department of Medical Biosciences, Pathology Umeå, University of Umeå, Sweden</nlm:aff></affiliation></author><author><name sortKey="Jirstrom, Karin" sort="Jirstrom, Karin" uniqKey="Jirstrom K" first="Karin" last="Jirström">Karin Jirström</name><affiliation><nlm:aff id="A34"> Department of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A35"> Department of Surgery, Skåne University Hospital, Lund University, Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Manjer, Jonas" sort="Manjer, Jonas" uniqKey="Manjer J" first="Jonas" last="Manjer">Jonas Manjer</name><affiliation><nlm:aff id="A34"> Department of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A35"> Department of Surgery, Skåne University Hospital, Lund University, Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A36"> Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:aff id="A37"> University of Cambridge School of Clinical Medicine, Clinical Gerontology, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Byrne, Karl Smith" sort="Byrne, Karl Smith" uniqKey="Byrne K" first="Karl Smith" last="Byrne">Karl Smith Byrne</name><affiliation><nlm:aff id="A38"> Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation><nlm:aff id="A38"> Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J." last="Gunter">Marc J. Gunter</name><affiliation><nlm:aff id="A39"> Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Merritt, Melissa A" sort="Merritt, Melissa A" uniqKey="Merritt M" first="Melissa A." last="Merritt">Melissa A. Merritt</name><affiliation><nlm:aff id="A39"> Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation><nlm:aff id="A39"> Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Cramer, Daniel W" sort="Cramer, Daniel W" uniqKey="Cramer D" first="Daniel W." last="Cramer">Daniel W. Cramer</name><affiliation><nlm:aff id="A1"> Ob/Gyn Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation><nlm:aff id="A2"> Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Clinical cancer research : an official journal of the American Association for Cancer Research</title><idno type="ISSN">1078-0432</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title><p id="P1">About 60% of ovarian cancers are diagnosed at late stage, when 5-year survival is less than 30% in contrast to 90% for local disease. This has prompted search for early detection biomarkers. For initial testing, specimens taken months or years before ovarian cancer diagnosis are the best source of information to evaluate early detection biomarkers. Here we evaluate the most promising ovarian cancer screening biomarkers in prospectively collected samples from the European Prospective Investigation into Cancer and Nutrition study.</p></sec><sec id="S2"><title>Experimental Design</title><p id="P2">We measured CA125, HE4, CA72.4 and CA15.3 in 810 invasive epithelial ovarian cancer cases and 1,939 controls. We calculated the sensitivity at 95% and 98% specificity as well as Area under the Receiver Operator Curve (C-statistic) for each marker individually and in combination. Additionally, we evaluated marker performance by stage at diagnosis and time between blood draw and diagnosis.</p></sec><sec id="S3"><title>Results</title><p id="P3">We observed the best discrimination between cases and controls within six months of diagnosis for CA125 (C-statistic=0.92), then HE4 (0.84), CA72.4 (0.77), and CA15.3 (0.73). Marker performance declined with longer time between blood draw and diagnosis and for earlier staged disease. However, assessment of discriminatory ability at early stage was limited by small numbers. Combinations of markers performed modestly, but significantly better than any single marker.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">CA125 remains the single best marker for the early detection of invasive epithelial ovarian cancer, but can be slightly improved by combining with other markers. Identifying novel markers for ovarian cancer will require studies including larger numbers of early stage cases.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9502500</journal-id><journal-id journal-id-type="pubmed-jr-id">8794</journal-id><journal-id journal-id-type="nlm-ta">Clin Cancer Res</journal-id><journal-id journal-id-type="iso-abbrev">Clin. Cancer Res.</journal-id><journal-title-group><journal-title>Clinical cancer research : an official journal of the American Association for Cancer Research</journal-title></journal-title-group><issn pub-type="ppub">1078-0432</issn></journal-meta><article-meta><article-id pub-id-type="pmid">27060155</article-id><article-id pub-id-type="pmc">5026545</article-id><article-id pub-id-type="doi">10.1158/1078-0432.CCR-16-0316</article-id><article-id pub-id-type="manuscript">NIHMS777015</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>A prospective evaluation of early detection biomarkers for ovarian cancer in the European EPIC cohort</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Terry</surname><given-names>Kathryn L.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="corresp" rid="CR1">*</xref></contrib><contrib contrib-type="author"><name><surname>Schock</surname><given-names>Helena</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Fortner</surname><given-names>Renée T.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Hüsing</surname><given-names>Anika</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Fichorova</surname><given-names>Raina N.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Yamamoto</surname><given-names>Hidemi S.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Vitonis</surname><given-names>Allison F.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Johnson</surname><given-names>Theron</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Overvad</surname><given-names>Kim</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Tjønneland</surname><given-names>Anne</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Boutron-Ruault</surname><given-names>Marie-Christine</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Mesrine</surname><given-names>Sylvie</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Severi</surname><given-names>Gianluca</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A9">9</xref><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Dossus</surname><given-names>Laure</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Rinaldi</surname><given-names>Sabina</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Boeing</surname><given-names>Heiner</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Benetou</surname><given-names>Vassiliki</given-names></name><xref ref-type="aff" rid="A13">13</xref><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Lagiou</surname><given-names>Pagona</given-names></name><xref ref-type="aff" rid="A13">13</xref><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Trichopoulou</surname><given-names>Antonia</given-names></name><xref ref-type="aff" rid="A13">13</xref><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Krogh</surname><given-names>Vittorio</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Kuhn</surname><given-names>Elisabetta</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Panico</surname><given-names>Salvatore</given-names></name><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Bueno-de-Mesquita</surname><given-names>H. Bas</given-names></name><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Onland-Moret</surname><given-names>N. Charlotte</given-names></name><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Peeters</surname><given-names>Petra H.</given-names></name><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Gram</surname><given-names>Inger Torhild</given-names></name><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Weiderpass</surname><given-names>Elisabete</given-names></name><xref ref-type="aff" rid="A20">20</xref><xref ref-type="aff" rid="A21">21</xref><xref ref-type="aff" rid="A22">22</xref><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Duell</surname><given-names>Eric J.</given-names></name><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Sanchez</surname><given-names>Maria-Jose</given-names></name><xref ref-type="aff" rid="A25">25</xref><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Ardanaz</surname><given-names>Eva</given-names></name><xref ref-type="aff" rid="A26">26</xref><xref ref-type="aff" rid="A27">27</xref><xref ref-type="aff" rid="A28">28</xref></contrib><contrib contrib-type="author"><name><surname>Etxezarreta</surname><given-names>Nerea</given-names></name><xref ref-type="aff" rid="A26">26</xref><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Navarro</surname><given-names>Carmen</given-names></name><xref ref-type="aff" rid="A26">26</xref><xref ref-type="aff" rid="A30">30</xref><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>Idahl</surname><given-names>Annika</given-names></name><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Lundin</surname><given-names>Eva</given-names></name><xref ref-type="aff" rid="A33">33</xref></contrib><contrib contrib-type="author"><name><surname>Jirström</surname><given-names>Karin</given-names></name><xref ref-type="aff" rid="A34">34</xref><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Manjer</surname><given-names>Jonas</given-names></name><xref ref-type="aff" rid="A34">34</xref><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Wareham</surname><given-names>Nicholas J.</given-names></name><xref ref-type="aff" rid="A36">36</xref></contrib><contrib contrib-type="author"><name><surname>Khaw</surname><given-names>Kay-Tee</given-names></name><xref ref-type="aff" rid="A37">37</xref></contrib><contrib contrib-type="author"><name><surname>Byrne</surname><given-names>Karl Smith</given-names></name><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Travis</surname><given-names>Ruth C.</given-names></name><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Gunter</surname><given-names>Marc J.</given-names></name><xref ref-type="aff" rid="A39">39</xref></contrib><contrib contrib-type="author"><name><surname>Merritt</surname><given-names>Melissa A.</given-names></name><xref ref-type="aff" rid="A39">39</xref></contrib><contrib contrib-type="author"><name><surname>Riboli</surname><given-names>Elio</given-names></name><xref ref-type="aff" rid="A39">39</xref></contrib><contrib contrib-type="author"><name><surname>Cramer</surname><given-names>Daniel W.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kaaks</surname><given-names>Rudolf</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="corresp" rid="CR1">*</xref></contrib></contrib-group><aff id="A1"><label>1</label> Ob/Gyn Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA</aff><aff id="A2"><label>2</label> Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA</aff><aff id="A3"><label>3</label> Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A4"><label>4</label> Genital Tract Biology Laboratory, Brigham and Women's Hospital, Boston, MA, USA</aff><aff id="A5"><label>5</label> Department of Epidemiology, Aarhus University, Aarhus, Denmark</aff><aff id="A6"><label>6</label> Danish Cancer Society Research Center, Copenhagen, Denmark</aff><aff id="A7"><label>7</label> Université Paris-Sud, Centre de recherche en Épidémiologie et Santé des Populations (CESP), Institut Nationale de Santë et de Recherche Médicale (INSERM), Villejuif, France</aff><aff id="A8"><label>8</label> Gustave Roussy, F-94805, Villejuif, France</aff><aff id="A9"><label>9</label> Human Genetics Foundation (HuGeF), Torino, Italy</aff><aff id="A10"><label>10</label> Cancer Council Victoria and University of Melbourne, Australia</aff><aff id="A11"><label>11</label> International Agency for Research on Cancer, Lyon, France, Nutrition and Metabolism section</aff><aff id="A12"><label>12</label> Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany</aff><aff id="A13"><label>13</label> Helenic Health Foundation Athens, Greece</aff><aff id="A14"><label>14</label> WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Greece</aff><aff id="A15"><label>15</label> Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy</aff><aff id="A16"><label>16</label> Department of Morphology, Surgery and Experimental Medicine and Laboratorio per le Tecnologie delle Terapie Avanzate (LTTA) Centre, University of Ferrara, Ferrara, Italy</aff><aff id="A17"><label>17</label> Dipartimento di Medicina Clinical e Chirurgia, Federico II University, Naples, Italy</aff><aff id="A18"><label>18</label> National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</aff><aff id="A19"><label>19</label> Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands</aff><aff id="A20"><label>20</label> Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway</aff><aff id="A21"><label>21</label> Department of Research, Cancer Registry of Norway, Institute of Population-Based Case Research, Oslo, Norway</aff><aff id="A22"><label>22</label> Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden</aff><aff id="A23"><label>23</label> Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland</aff><aff id="A24"><label>24</label> Unit of Nutrition and Cancer Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute, Catalan Institute of Oncology, Barcelona, Spain</aff><aff id="A25"><label>25</label> Escuela Andaluza de Salud Publica, Instituto de Investigación Bionsanitaria ibs. Granada, Hospitales Universitarios de Granada, Granada, Spain</aff><aff id="A26"><label>26</label> Centro de Investigación Biomédica En Red (CIBER) , Section Epidemiology and Public Health (CIBERESP), Madrid, Spain</aff><aff id="A27"><label>27</label> Navarra Public Health Institute, Pamplona, Spain</aff><aff id="A28"><label>28</label> IdiSNA, Navarra Institute for Health Research, Pamplona, Spain</aff><aff id="A29"><label>29</label> Public Health Division of Gipuzkoa, Regional Government of the Basque Country, Spain</aff><aff id="A30"><label>30</label> Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain</aff><aff id="A31"><label>31</label> Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain</aff><aff id="A32"><label>32</label> Department of Clinical Sciences, Obstetrics and Gynecology Umeå, University of Umeå, Sweden</aff><aff id="A33"><label>33</label> Department of Medical Biosciences, Pathology Umeå, University of Umeå, Sweden</aff><aff id="A34"><label>34</label> Department of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund, Sweden</aff><aff id="A35"><label>35</label> Department of Surgery, Skåne University Hospital, Lund University, Malmö, Sweden</aff><aff id="A36"><label>36</label> Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom</aff><aff id="A37"><label>37</label> University of Cambridge School of Clinical Medicine, Clinical Gerontology, Cambridge, United Kingdom</aff><aff id="A38"><label>38</label> Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom</aff><aff id="A39"><label>39</label> Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, United Kingdom</aff><author-notes><corresp id="CR1"><label>*</label><bold>Corresponding authors: Kathryn Terry</bold> Obstetrics and Gynecology Epidemiology Center Brigham and Women's Hospital and Harvard Medical School, 221 Longwod, Boston, MA 02115, USA. Phone: (617) 732-8596, Fax: (617) 732-4899, <email>kterry@partners.org</email>, <bold>Rudolf Kaaks</bold> Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany. Phone: +49 6221 422200, Fax: +49 6221 422203, <email>r.kaaks@dkfz-heidelberg.de</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>29</day><month>4</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>08</day><month>4</month><year>2016</year></pub-date><pub-date pub-type="ppub"><day>15</day><month>9</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>9</month><year>2017</year></pub-date><volume>22</volume><issue>18</issue><fpage>4664</fpage><lpage>4675</lpage><pmc-comment>elocation-id from pubmed: 10.1158/1078-0432.CCR-16-0316</pmc-comment>
<abstract><sec id="S1"><title>Purpose</title><p id="P1">About 60% of ovarian cancers are diagnosed at late stage, when 5-year survival is less than 30% in contrast to 90% for local disease. This has prompted search for early detection biomarkers. For initial testing, specimens taken months or years before ovarian cancer diagnosis are the best source of information to evaluate early detection biomarkers. Here we evaluate the most promising ovarian cancer screening biomarkers in prospectively collected samples from the European Prospective Investigation into Cancer and Nutrition study.</p></sec><sec id="S2"><title>Experimental Design</title><p id="P2">We measured CA125, HE4, CA72.4 and CA15.3 in 810 invasive epithelial ovarian cancer cases and 1,939 controls. We calculated the sensitivity at 95% and 98% specificity as well as Area under the Receiver Operator Curve (C-statistic) for each marker individually and in combination. Additionally, we evaluated marker performance by stage at diagnosis and time between blood draw and diagnosis.</p></sec><sec id="S3"><title>Results</title><p id="P3">We observed the best discrimination between cases and controls within six months of diagnosis for CA125 (C-statistic=0.92), then HE4 (0.84), CA72.4 (0.77), and CA15.3 (0.73). Marker performance declined with longer time between blood draw and diagnosis and for earlier staged disease. However, assessment of discriminatory ability at early stage was limited by small numbers. Combinations of markers performed modestly, but significantly better than any single marker.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">CA125 remains the single best marker for the early detection of invasive epithelial ovarian cancer, but can be slightly improved by combining with other markers. Identifying novel markers for ovarian cancer will require studies including larger numbers of early stage cases.</p></sec></abstract><kwd-group><kwd>ovarian cancer</kwd><kwd>CA125</kwd><kwd>HE4</kwd><kwd>CA15.3</kwd><kwd>Ca72.4</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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