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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A common variant mapping to <italic>CACNA1A</italic> is associated with susceptibility to Exfoliation syndrome</title><author><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Singapore National Eye Center, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</nlm:aff></affiliation></author><author><name sortKey="Ozaki, Mineo" sort="Ozaki, Mineo" uniqKey="Ozaki M" first="Mineo" last="Ozaki">Mineo Ozaki</name><affiliation><nlm:aff id="A4">Ozaki Eye Hospital, 1-15, Kamezaki, Hyuga, Miyazaki 883-0066 Japan</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Hayashi Eye Hospital, 4-23-35, Hakataekimae, Hakata-ku, Fukuoka, Japan</nlm:aff></affiliation></author><author><name sortKey="Mizoguchi, Takanori" sort="Mizoguchi, Takanori" uniqKey="Mizoguchi T" first="Takanori" last="Mizoguchi">Takanori Mizoguchi</name><affiliation><nlm:aff id="A5">Mizoguchi Eye Hospital, 6-13 Tawara-machi, Sasebo, Nagasaki, Japan 857-0016</nlm:aff></affiliation></author><author><name sortKey="Allingham, R Rand" sort="Allingham, R Rand" uniqKey="Allingham R" first="R Rand" last="Allingham">R Rand Allingham</name><affiliation><nlm:aff id="A6">Department of Ophthalmology, Duke University Eye Center, Durham, NC</nlm:aff></affiliation></author><author><name sortKey="Li, Zheng" sort="Li, Zheng" uniqKey="Li Z" first="Zheng" last="Li">Zheng Li</name><affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff></affiliation></author><author><name sortKey="Haripriya, Aravind" sort="Haripriya, Aravind" uniqKey="Haripriya A" first="Aravind" last="Haripriya">Aravind Haripriya</name><affiliation><nlm:aff id="A8">Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai, India</nlm:aff></affiliation></author><author><name sortKey="Nakano, Satoko" sort="Nakano, Satoko" uniqKey="Nakano S" first="Satoko" last="Nakano">Satoko Nakano</name><affiliation><nlm:aff id="A9">Department of Ophthalmology, Oita University Faculty of Medicine</nlm:aff></affiliation></author><author><name sortKey="Uebe, Steffen" sort="Uebe, Steffen" uniqKey="Uebe S" first="Steffen" last="Uebe">Steffen Uebe</name><affiliation><nlm:aff id="A10">Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Harder, Jeffrey M" sort="Harder, Jeffrey M" uniqKey="Harder J" first="Jeffrey M." last="Harder">Jeffrey M. Harder</name><affiliation><nlm:aff id="A11">The Howard Hughes Medical Institute, the Jackson Laboratory 600 Main Street, Bar Harbor, ME 04609</nlm:aff></affiliation></author><author><name sortKey="Chan, Anita S Y" sort="Chan, Anita S Y" uniqKey="Chan A" first="Anita S. Y." last="Chan">Anita S. Y. Chan</name><affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Singapore National Eye Center, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation></author><author><name sortKey="Lee, Mei Chin" sort="Lee, Mei Chin" uniqKey="Lee M" first="Mei Chin" last="Lee">Mei Chin Lee</name><affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation></author><author><name sortKey="Burdon, Kathryn P" sort="Burdon, Kathryn P" uniqKey="Burdon K" first="Kathryn P." last="Burdon">Kathryn P. Burdon</name><affiliation><nlm:aff id="A12">Department of Ophthalmology, Flinders University, Adelaide, SA, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Menzies Institute for Medical Research, University of Tasmania</nlm:aff></affiliation></author><author><name sortKey="Astakhov, Yury S" sort="Astakhov, Yury S" uniqKey="Astakhov Y" first="Yury S." last="Astakhov">Yury S. Astakhov</name><affiliation><nlm:aff id="A14">Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, 6/8 L’va Tolstogo Street, 197022 St. Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Abu Amero, Khaled K" sort="Abu Amero, Khaled K" uniqKey="Abu Amero K" first="Khaled K." last="Abu-Amero">Khaled K. Abu-Amero</name><affiliation><nlm:aff id="A15">Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Department of Ophthalmology, College of Medicine, University of Florida, Jacksonville, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Zenteno, Juan C" sort="Zenteno, Juan C" uniqKey="Zenteno J" first="Juan C." last="Zenteno">Juan C. Zenteno</name><affiliation><nlm:aff id="A17">Genetics Department, Institute of Ophthalmology “Conde de Valenciana”, Mexico</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Biochemistry Department, Faculty of Medicine, UNAM, Mexico City, Mexico</nlm:aff></affiliation></author><author><name sortKey="Nilgun, Yildirim" sort="Nilgun, Yildirim" uniqKey="Nilgun Y" first="Yildirim" last="Nilgün">Yildirim Nilgün</name><affiliation><nlm:aff id="A19">Department of Ophthalmology, Eskisehir Osmangazi University, Meselik, Eskisehir, Turkey</nlm:aff></affiliation></author><author><name sortKey="Zarnowski, Tomasz" sort="Zarnowski, Tomasz" uniqKey="Zarnowski T" first="Tomasz" last="Zarnowski">Tomasz Zarnowski</name><affiliation><nlm:aff id="A20">Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland, Chmielna 1, 20-079 Lublin, Poland</nlm:aff></affiliation></author><author><name sortKey="Pakravan, Mohammad" sort="Pakravan, Mohammad" uniqKey="Pakravan M" first="Mohammad" last="Pakravan">Mohammad Pakravan</name><affiliation><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Safieh, Leen Abu" sort="Safieh, Leen Abu" uniqKey="Safieh L" first="Leen Abu" last="Safieh">Leen Abu Safieh</name><affiliation><nlm:aff id="A22">King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Jia, Liyun" sort="Jia, Liyun" uniqKey="Jia L" first="Liyun" last="Jia">Liyun Jia</name><affiliation><nlm:aff id="A23">Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China</nlm:aff></affiliation></author><author><name sortKey="Wang, Ya Xing" sort="Wang, Ya Xing" uniqKey="Wang Y" first="Ya Xing" last="Wang">Ya Xing Wang</name><affiliation><nlm:aff id="A24">Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China</nlm:aff></affiliation></author><author><name sortKey="Williams, Susan" sort="Williams, Susan" uniqKey="Williams S" first="Susan" last="Williams">Susan Williams</name><affiliation><nlm:aff id="A25">Division of Ophthalmology, Department of Neurosciences, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff></affiliation></author><author><name sortKey="Paoli, Daniela" sort="Paoli, Daniela" uniqKey="Paoli D" first="Daniela" last="Paoli">Daniela Paoli</name><affiliation><nlm:aff id="A26">Department of Ophthalmology, Monfalcone Hospital, Gorizia, Italy</nlm:aff></affiliation></author><author><name sortKey="Schlottmann, Patricio G" sort="Schlottmann, Patricio G" uniqKey="Schlottmann P" first="Patricio G" last="Schlottmann">Patricio G. Schlottmann</name><affiliation><nlm:aff id="A27">Organización Médica de Investigación, Uruguay 725 – PB, Buenos Aires (C1015ABO) Argentina</nlm:aff></affiliation></author><author><name sortKey="Huang, Lulin" sort="Huang, Lulin" uniqKey="Huang L" first="Lulin" last="Huang">Lulin Huang</name><affiliation><nlm:aff id="A28">Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People’s Hospital, Chengdu, China</nlm:aff></affiliation><affiliation><nlm:aff id="A29">School of Medicine, University of Electronic Science and Technology of China, Chengdu, China</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, China</nlm:aff></affiliation></author><author><name sortKey="Sim, Kar Seng" sort="Sim, Kar Seng" uniqKey="Sim K" first="Kar Seng" last="Sim">Kar Seng Sim</name><affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff></affiliation></author><author><name sortKey="Foo, Jia Nee" sort="Foo, Jia Nee" uniqKey="Foo J" first="Jia Nee" last="Foo">Jia Nee Foo</name><affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff></affiliation></author><author><name sortKey="Nakano, Masakazu" sort="Nakano, Masakazu" uniqKey="Nakano M" first="Masakazu" last="Nakano">Masakazu Nakano</name><affiliation><nlm:aff id="A31">Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Ikeda, Yoko" sort="Ikeda, Yoko" uniqKey="Ikeda Y" first="Yoko" last="Ikeda">Yoko Ikeda</name><affiliation><nlm:aff id="A32">Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Kumar, Rajesh S" sort="Kumar, Rajesh S" uniqKey="Kumar R" first="Rajesh S" last="Kumar">Rajesh S. Kumar</name><affiliation><nlm:aff id="A33">Glaucoma services, Narayana Nethralaya Eye Hospital, 121/C, Chord Road, Rajajinagar, 1st R Block, Bangalore 560 010, India</nlm:aff></affiliation></author><author><name sortKey="Ueno, Morio" sort="Ueno, Morio" uniqKey="Ueno M" first="Morio" last="Ueno">Morio Ueno</name><affiliation><nlm:aff id="A32">Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Manabe, Shin Ichi" sort="Manabe, Shin Ichi" uniqKey="Manabe S" first="Shin-Ichi" last="Manabe">Shin-Ichi Manabe</name><affiliation><nlm:aff id="A34">Hayashi Eye Hospital, 4-23-35, Hakataekimae, Hakata-ku, Fukuoka, Japan</nlm:aff></affiliation></author><author><name sortKey="Hayashi, Ken" sort="Hayashi, Ken" uniqKey="Hayashi K" first="Ken" last="Hayashi">Ken Hayashi</name><affiliation><nlm:aff id="A34">Hayashi Eye Hospital, 4-23-35, Hakataekimae, Hakata-ku, Fukuoka, Japan</nlm:aff></affiliation></author><author><name sortKey="Kazama, Shigeyasu" sort="Kazama, Shigeyasu" uniqKey="Kazama S" first="Shigeyasu" last="Kazama">Shigeyasu Kazama</name><affiliation><nlm:aff id="A35">Shinjo Eye Clinic, 889-1,Mego, Simokitakatamachi, Miyazaki-shi, Miyazaki 880-0035,Japan</nlm:aff></affiliation></author><author><name sortKey="Ideta, Ryuichi" sort="Ideta, Ryuichi" uniqKey="Ideta R" first="Ryuichi" last="Ideta">Ryuichi Ideta</name><affiliation><nlm:aff id="A36">Ideta Eye Hospital, Kumamoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Mori, Yosai" sort="Mori, Yosai" uniqKey="Mori Y" first="Yosai" last="Mori">Yosai Mori</name><affiliation><nlm:aff id="A37">Miyata Eye Hospital, 6-3, Kurahara, Miyakonojo, Miyazaki 885-0051 Japan</nlm:aff></affiliation></author><author><name sortKey="Miyata, Kazunori" sort="Miyata, Kazunori" uniqKey="Miyata K" first="Kazunori" last="Miyata">Kazunori Miyata</name><affiliation><nlm:aff id="A37">Miyata Eye Hospital, 6-3, Kurahara, Miyakonojo, Miyazaki 885-0051 Japan</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan</nlm:aff></affiliation></author><author><name sortKey="Sugiyama, Kazuhisa" sort="Sugiyama, Kazuhisa" uniqKey="Sugiyama K" first="Kazuhisa" last="Sugiyama">Kazuhisa Sugiyama</name><affiliation><nlm:aff id="A39">Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan</nlm:aff></affiliation></author><author><name sortKey="Higashide, Tomomi" sort="Higashide, Tomomi" uniqKey="Higashide T" first="Tomomi" last="Higashide">Tomomi Higashide</name><affiliation><nlm:aff id="A39">Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan</nlm:aff></affiliation></author><author><name sortKey="Chihara, Etsuo" sort="Chihara, Etsuo" uniqKey="Chihara E" first="Etsuo" last="Chihara">Etsuo Chihara</name><affiliation><nlm:aff id="A40">Sensho-kai Eye Institute, Minamiyama 50-1, Iseda, Uji, Kyoto 611-0043, Japan</nlm:aff></affiliation></author><author><name sortKey="Inoue, Kenji" sort="Inoue, Kenji" uniqKey="Inoue K" first="Kenji" last="Inoue">Kenji Inoue</name><affiliation><nlm:aff id="A41">Inouye Eye Hospital, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Ishiko, Satoshi" sort="Ishiko, Satoshi" uniqKey="Ishiko S" first="Satoshi" last="Ishiko">Satoshi Ishiko</name><affiliation><nlm:aff id="A42">Department of Medicine and Engineering Combined Research Institute, Asahikawa Medical University, Asahikawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Yoshida, Akitoshi" sort="Yoshida, Akitoshi" uniqKey="Yoshida A" first="Akitoshi" last="Yoshida">Akitoshi Yoshida</name><affiliation><nlm:aff id="A43">Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Yanagi, Masahide" sort="Yanagi, Masahide" uniqKey="Yanagi M" first="Masahide" last="Yanagi">Masahide Yanagi</name><affiliation><nlm:aff id="A44">Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima, Japan</nlm:aff></affiliation></author><author><name sortKey="Kiuchi, Yoshiaki" sort="Kiuchi, Yoshiaki" uniqKey="Kiuchi Y" first="Yoshiaki" last="Kiuchi">Yoshiaki Kiuchi</name><affiliation><nlm:aff id="A44">Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima, Japan</nlm:aff></affiliation></author><author><name sortKey="Aihara, Makoto" sort="Aihara, Makoto" uniqKey="Aihara M" first="Makoto" last="Aihara">Makoto Aihara</name><affiliation><nlm:aff id="A45">Yotsuya Shirato Eye Clinic, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Ohashi, Tsutomu" sort="Ohashi, Tsutomu" uniqKey="Ohashi T" first="Tsutomu" last="Ohashi">Tsutomu Ohashi</name><affiliation><nlm:aff id="A46">Ohashi eye center, Kita1-1 Hondori6 Shiroishi-ku Sapporo 003-0027 Japan</nlm:aff></affiliation></author><author><name sortKey="Sakurai, Toshiya" sort="Sakurai, Toshiya" uniqKey="Sakurai T" first="Toshiya" last="Sakurai">Toshiya Sakurai</name><affiliation><nlm:aff id="A47">Tane Memorial Eye Hospital, Osaka</nlm:aff></affiliation></author><author><name sortKey="Sugimoto, Takako" sort="Sugimoto, Takako" uniqKey="Sugimoto T" first="Takako" last="Sugimoto">Takako Sugimoto</name><affiliation><nlm:aff id="A38">Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan</nlm:aff></affiliation></author><author><name sortKey="Chuman, Hideki" sort="Chuman, Hideki" uniqKey="Chuman H" first="Hideki" last="Chuman">Hideki Chuman</name><affiliation><nlm:aff id="A38">Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan</nlm:aff></affiliation></author><author><name sortKey="Matsuda, Fumihiko" sort="Matsuda, Fumihiko" uniqKey="Matsuda F" first="Fumihiko" last="Matsuda">Fumihiko Matsuda</name><affiliation><nlm:aff id="A48">Center for Genomic Medicine/Inserm U.852, Kyoto University Graduate School of Medicine, Kyoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Yamashiro, Kenji" sort="Yamashiro, Kenji" uniqKey="Yamashiro K" first="Kenji" last="Yamashiro">Kenji Yamashiro</name><affiliation><nlm:aff id="A49">Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Gotoh, Norimoto" sort="Gotoh, Norimoto" uniqKey="Gotoh N" first="Norimoto" last="Gotoh">Norimoto Gotoh</name><affiliation><nlm:aff id="A49">Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Miyake, Masahiro" sort="Miyake, Masahiro" uniqKey="Miyake M" first="Masahiro" last="Miyake">Masahiro Miyake</name><affiliation><nlm:aff id="A48">Center for Genomic Medicine/Inserm U.852, Kyoto University Graduate School of Medicine, Kyoto, Japan</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Astakhov, Sergei Y" sort="Astakhov, Sergei Y" uniqKey="Astakhov S" first="Sergei Y." last="Astakhov">Sergei Y. Astakhov</name><affiliation><nlm:aff id="A14">Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, 6/8 L’va Tolstogo Street, 197022 St. Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Osman, Essam A" sort="Osman, Essam A" uniqKey="Osman E" first="Essam A." last="Osman">Essam A. Osman</name><affiliation><nlm:aff id="A15">Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Al Obeidan, Saleh A" sort="Al Obeidan, Saleh A" uniqKey="Al Obeidan S" first="Saleh A." last="Al-Obeidan">Saleh A. Al-Obeidan</name><affiliation><nlm:aff id="A15">Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Owaidhah, Ohoud" sort="Owaidhah, Ohoud" uniqKey="Owaidhah O" first="Ohoud" last="Owaidhah">Ohoud Owaidhah</name><affiliation><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Al Jasim, Leyla" sort="Al Jasim, Leyla" uniqKey="Al Jasim L" first="Leyla" last="Al-Jasim">Leyla Al-Jasim</name><affiliation><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Al Shahwan, Sami" sort="Al Shahwan, Sami" uniqKey="Al Shahwan S" first="Sami" last="Al Shahwan">Sami Al Shahwan</name><affiliation><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Fogarty, Rhys A" sort="Fogarty, Rhys A" uniqKey="Fogarty R" first="Rhys A." last="Fogarty">Rhys A. Fogarty</name><affiliation><nlm:aff id="A12">Department of Ophthalmology, Flinders University, Adelaide, SA, Australia</nlm:aff></affiliation></author><author><name sortKey="Leo, Paul" sort="Leo, Paul" uniqKey="Leo P" first="Paul" last="Leo">Paul Leo</name><affiliation><nlm:aff id="A50">University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Qld, Australia</nlm:aff></affiliation></author><author><name sortKey="Yetkin, Yaz" sort="Yetkin, Yaz" uniqKey="Yetkin Y" first="Yaz" last="Yetkin">Yaz Yetkin</name><affiliation><nlm:aff id="A19">Department of Ophthalmology, Eskisehir Osmangazi University, Meselik, Eskisehir, Turkey</nlm:aff></affiliation></author><author><name sortKey="O Uz, Cilingir" sort="O Uz, Cilingir" uniqKey="O Uz C" first="Çilingir" last="O Uz">Çilingir O Uz</name><affiliation><nlm:aff id="A19">Department of Ophthalmology, Eskisehir Osmangazi University, Meselik, Eskisehir, Turkey</nlm:aff></affiliation></author><author><name sortKey="Kanavi, Mozhgan Rezaei" sort="Kanavi, Mozhgan Rezaei" uniqKey="Kanavi M" first="Mozhgan Rezaei" last="Kanavi">Mozhgan Rezaei Kanavi</name><affiliation><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Beni, Afsaneh Naderi" sort="Beni, Afsaneh Naderi" uniqKey="Beni A" first="Afsaneh Naderi" last="Beni">Afsaneh Naderi Beni</name><affiliation><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Yazdani, Shahin" sort="Yazdani, Shahin" uniqKey="Yazdani S" first="Shahin" last="Yazdani">Shahin Yazdani</name><affiliation><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Akopov, Evgeny L" sort="Akopov, Evgeny L" uniqKey="Akopov E" first="Evgeny L." last="Akopov">Evgeny L. Akopov</name><affiliation><nlm:aff id="A14">Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, 6/8 L’va Tolstogo Street, 197022 St. Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Toh, Kai Yee" sort="Toh, Kai Yee" uniqKey="Toh K" first="Kai-Yee" last="Toh">Kai-Yee Toh</name><affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff></affiliation></author><author><name sortKey="Howell, Gareth R" sort="Howell, Gareth R" uniqKey="Howell G" first="Gareth R" last="Howell">Gareth R. Howell</name><affiliation><nlm:aff id="A11">The Howard Hughes Medical Institute, the Jackson Laboratory 600 Main Street, Bar Harbor, ME 04609</nlm:aff></affiliation></author><author><name sortKey="Orr, Andrew C" sort="Orr, Andrew C" uniqKey="Orr A" first="Andrew C." last="Orr">Andrew C. Orr</name><affiliation><nlm:aff id="A51">Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Canada</nlm:aff></affiliation></author><author><name sortKey="Goh, Yufen" sort="Goh, Yufen" uniqKey="Goh Y" first="Yufen" last="Goh">Yufen Goh</name><affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff></affiliation></author><author><name sortKey="Meah, Wee Yang" sort="Meah, Wee Yang" uniqKey="Meah W" first="Wee Yang" last="Meah">Wee Yang Meah</name><affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff></affiliation></author><author><name sortKey="Peh, Su Qin" sort="Peh, Su Qin" uniqKey="Peh S" first="Su Qin" last="Peh">Su Qin Peh</name><affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff></affiliation></author><author><name sortKey="Kosior Jarecka, Ewa" sort="Kosior Jarecka, Ewa" uniqKey="Kosior Jarecka E" first="Ewa" last="Kosior-Jarecka">Ewa Kosior-Jarecka</name><affiliation><nlm:aff id="A20">Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland, Chmielna 1, 20-079 Lublin, Poland</nlm:aff></affiliation></author><author><name sortKey="Lukasik, Urszula" sort="Lukasik, Urszula" uniqKey="Lukasik U" first="Urszula" last="Lukasik">Urszula Lukasik</name><affiliation><nlm:aff id="A20">Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland, Chmielna 1, 20-079 Lublin, Poland</nlm:aff></affiliation></author><author><name sortKey="Krumbiegel, Mandy" sort="Krumbiegel, Mandy" uniqKey="Krumbiegel M" first="Mandy" last="Krumbiegel">Mandy Krumbiegel</name><affiliation><nlm:aff id="A10">Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Vithana, Eranga N" sort="Vithana, Eranga N" uniqKey="Vithana E" first="Eranga N" last="Vithana">Eranga N. Vithana</name><affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation></author><author><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien Yin" last="Wong">Tien Yin Wong</name><affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Singapore National Eye Center, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</nlm:aff></affiliation></author><author><name sortKey="Liu, Yutao" sort="Liu, Yutao" uniqKey="Liu Y" first="Yutao" last="Liu">Yutao Liu</name><affiliation><nlm:aff id="A52">Department of Medicine, Duke University Medical Center, Durham, North Carolina</nlm:aff></affiliation><affiliation><nlm:aff id="A53">Department of Cellular Biology and Anatomy, Georgia Regents University, Augusta, Georgia</nlm:aff></affiliation></author><author><name sortKey="Ashley Koch, Allison E" sort="Ashley Koch, Allison E" uniqKey="Ashley Koch A" first="Allison E." last="Ashley Koch">Allison E. Ashley Koch</name><affiliation><nlm:aff id="A52">Department of Medicine, Duke University Medical Center, Durham, North Carolina</nlm:aff></affiliation></author><author><name sortKey="Challa, Pratap" sort="Challa, Pratap" uniqKey="Challa P" first="Pratap" last="Challa">Pratap Challa</name><affiliation><nlm:aff id="A6">Department of Ophthalmology, Duke University Eye Center, Durham, NC</nlm:aff></affiliation></author><author><name sortKey="Rautenbach, Robyn M" sort="Rautenbach, Robyn M" uniqKey="Rautenbach R" first="Robyn M" last="Rautenbach">Robyn M. Rautenbach</name><affiliation><nlm:aff id="A54">Division of Ophthalmology, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A." last="Mackey">David A. Mackey</name><affiliation><nlm:aff id="A55">Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Australia</nlm:aff></affiliation></author><author><name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W" last="Hewitt">Alex W. Hewitt</name><affiliation><nlm:aff id="A13">Menzies Institute for Medical Research, University of Tasmania</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name><affiliation><nlm:aff id="A57">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, NSW Australia</nlm:aff></affiliation></author><author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name><affiliation><nlm:aff id="A57">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, NSW Australia</nlm:aff></affiliation></author><author><name sortKey="Ziskind, Ari" sort="Ziskind, Ari" uniqKey="Ziskind A" first="Ari" last="Ziskind">Ari Ziskind</name><affiliation><nlm:aff id="A54">Division of Ophthalmology, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Carmichael, Trevor" sort="Carmichael, Trevor" uniqKey="Carmichael T" first="Trevor" last="Carmichael">Trevor Carmichael</name><affiliation><nlm:aff id="A25">Division of Ophthalmology, Department of Neurosciences, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff></affiliation></author><author><name sortKey="Ramakrishnan, Rangappa" sort="Ramakrishnan, Rangappa" uniqKey="Ramakrishnan R" first="Rangappa" last="Ramakrishnan">Rangappa Ramakrishnan</name><affiliation><nlm:aff id="A8">Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai, India</nlm:aff></affiliation></author><author><name sortKey="Narendran, Kalpana" sort="Narendran, Kalpana" uniqKey="Narendran K" first="Kalpana" last="Narendran">Kalpana Narendran</name><affiliation><nlm:aff id="A8">Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai, India</nlm:aff></affiliation></author><author><name sortKey="Venkatesh, Rangaraj" sort="Venkatesh, Rangaraj" uniqKey="Venkatesh R" first="Rangaraj" last="Venkatesh">Rangaraj Venkatesh</name><affiliation><nlm:aff id="A8">Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai, India</nlm:aff></affiliation></author><author><name sortKey="Vijayan, Saravanan" sort="Vijayan, Saravanan" uniqKey="Vijayan S" first="Saravanan" last="Vijayan">Saravanan Vijayan</name><affiliation><nlm:aff id="A58">Department of Genetics, Aravind Medical Research Foundation, Madurai, India</nlm:aff></affiliation></author><author><name sortKey="Zhao, Peiquan" sort="Zhao, Peiquan" uniqKey="Zhao P" first="Peiquan" last="Zhao">Peiquan Zhao</name><affiliation><nlm:aff id="A59">Department of Ophthalmology, Xin Hua Hospital affiliated to Shanghai Jiao Tong University, School of Medicine, No. 1665, Kongjiang Road, Shanghai 200092, China</nlm:aff></affiliation></author><author><name sortKey="Chen, Xueyi" sort="Chen, Xueyi" uniqKey="Chen X" first="Xueyi" last="Chen">Xueyi Chen</name><affiliation><nlm:aff id="A60">Department of Ophthalmology, the First Affiliated Hospital of Xinjiang Medical University, Urumchi 830054, Xinjiang Uygur Autonomous Region, China</nlm:aff></affiliation></author><author><name sortKey="Guadarrama Vallejo, Dalia" sort="Guadarrama Vallejo, Dalia" uniqKey="Guadarrama Vallejo D" first="Dalia" last="Guadarrama-Vallejo">Dalia Guadarrama-Vallejo</name><affiliation><nlm:aff id="A17">Genetics Department, Institute of Ophthalmology “Conde de Valenciana”, Mexico</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Biochemistry Department, Faculty of Medicine, UNAM, Mexico City, Mexico</nlm:aff></affiliation></author><author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching Yu" last="Cheng">Ching Yu Cheng</name><affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</nlm:aff></affiliation></author><author><name sortKey="Perera, Shamira A" sort="Perera, Shamira A" uniqKey="Perera S" first="Shamira A" last="Perera">Shamira A. Perera</name><affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Singapore National Eye Center, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation></author><author><name sortKey="Husain, Rahat" sort="Husain, Rahat" uniqKey="Husain R" first="Rahat" last="Husain">Rahat Husain</name><affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Singapore National Eye Center, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation></author><author><name sortKey="Ho, Su Ling" sort="Ho, Su Ling" uniqKey="Ho S" first="Su-Ling" last="Ho">Su-Ling Ho</name><affiliation><nlm:aff id="A61">National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore</nlm:aff></affiliation></author><author><name sortKey="Welge Luessen, Ulrich Christoph" sort="Welge Luessen, Ulrich Christoph" uniqKey="Welge Luessen U" first="Ulrich-Christoph" last="Welge-Luessen">Ulrich-Christoph Welge-Luessen</name><affiliation><nlm:aff id="A62">Department of Ophthalmology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Mardin, Christian" sort="Mardin, Christian" uniqKey="Mardin C" first="Christian" last="Mardin">Christian Mardin</name><affiliation><nlm:aff id="A62">Department of Ophthalmology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Schloetzer Schrehardt, Ursula" sort="Schloetzer Schrehardt, Ursula" uniqKey="Schloetzer Schrehardt U" first="Ursula" last="Schloetzer-Schrehardt">Ursula Schloetzer-Schrehardt</name><affiliation><nlm:aff id="A62">Department of Ophthalmology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hillmer, Axel M" sort="Hillmer, Axel M" uniqKey="Hillmer A" first="Axel M." last="Hillmer">Axel M. Hillmer</name><affiliation><nlm:aff id="A63">Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore</nlm:aff></affiliation></author><author><name sortKey="Herms, Stefan" sort="Herms, Stefan" uniqKey="Herms S" first="Stefan" last="Herms">Stefan Herms</name><affiliation><nlm:aff id="A64">Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Division of Medical Genetics, University Hospital, Basel, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Human Genetics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Moebus, Susanne" sort="Moebus, Susanne" uniqKey="Moebus S" first="Susanne" last="Moebus">Susanne Moebus</name><affiliation><nlm:aff id="A68">Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name><affiliation><nlm:aff id="A64">Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Weisschuh, Nicole" sort="Weisschuh, Nicole" uniqKey="Weisschuh N" first="Nicole" last="Weisschuh">Nicole Weisschuh</name><affiliation><nlm:aff id="A69">University Eye Hospital, Wuerzburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Shetty, Rohit" sort="Shetty, Rohit" uniqKey="Shetty R" first="Rohit" last="Shetty">Rohit Shetty</name><affiliation><nlm:aff id="A33">Glaucoma services, Narayana Nethralaya Eye Hospital, 121/C, Chord Road, Rajajinagar, 1st R Block, Bangalore 560 010, India</nlm:aff></affiliation></author><author><name sortKey="Ghosh, Arkasubhra" sort="Ghosh, Arkasubhra" uniqKey="Ghosh A" first="Arkasubhra" last="Ghosh">Arkasubhra Ghosh</name><affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation><affiliation><nlm:aff id="A70">Genes, Repair and Regeneration in Ophthalmic Workstation Research Lab, Narayana Nethralaya Foundation, Bangalore, India</nlm:aff></affiliation></author><author><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik Ying" last="Teo">Yik Ying Teo</name><affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="A71">Saw Swee Hock School of Public Health, National University of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Brown, Matthew A" sort="Brown, Matthew A" uniqKey="Brown M" first="Matthew A" last="Brown">Matthew A. Brown</name><affiliation><nlm:aff id="A50">University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Qld, Australia</nlm:aff></affiliation></author><author><name sortKey="Lischinsky, Ignacio" sort="Lischinsky, Ignacio" uniqKey="Lischinsky I" first="Ignacio" last="Lischinsky">Ignacio Lischinsky</name><affiliation><nlm:aff id="A72">Centro Oftalmologico Lischinsky, Junin 692, Tucuman (4000) – Argentina</nlm:aff></affiliation></author><author><name sortKey="Crowston, Jonathan G" sort="Crowston, Jonathan G" uniqKey="Crowston J" first="Jonathan G" last="Crowston">Jonathan G. Crowston</name><affiliation><nlm:aff id="A56">Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Department of Ophthalmology, University of Melbourne</nlm:aff></affiliation></author><author><name sortKey="Coote, Michael" sort="Coote, Michael" uniqKey="Coote M" first="Michael" last="Coote">Michael Coote</name><affiliation><nlm:aff id="A56">Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Department of Ophthalmology, University of Melbourne</nlm:aff></affiliation></author><author><name sortKey="Zhao, Bowen" sort="Zhao, Bowen" uniqKey="Zhao B" first="Bowen" last="Zhao">Bowen Zhao</name><affiliation><nlm:aff id="A22">King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Sang, Jinghong" sort="Sang, Jinghong" uniqKey="Sang J" first="Jinghong" last="Sang">Jinghong Sang</name><affiliation><nlm:aff id="A23">Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China</nlm:aff></affiliation></author><author><name sortKey="Zhang, Nihong" sort="Zhang, Nihong" uniqKey="Zhang N" first="Nihong" last="Zhang">Nihong Zhang</name><affiliation><nlm:aff id="A23">Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China</nlm:aff></affiliation></author><author><name sortKey="You, Qisheng" sort="You, Qisheng" uniqKey="You Q" first="Qisheng" last="You">Qisheng You</name><affiliation><nlm:aff id="A24">Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China</nlm:aff></affiliation></author><author><name sortKey="Vysochinskaya, Vera" sort="Vysochinskaya, Vera" uniqKey="Vysochinskaya V" first="Vera" last="Vysochinskaya">Vera Vysochinskaya</name><affiliation><nlm:aff id="A74">St. Petersburg Academic University, 8/3 Klopina Street, 194021 St. Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Founti, Panayiota" sort="Founti, Panayiota" uniqKey="Founti P" first="Panayiota" last="Founti">Panayiota Founti</name><affiliation><nlm:aff id="A75">Department of Ophthalmology, Faculty of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece</nlm:aff></affiliation></author><author><name sortKey="Chatzikyriakidou, Anthoula" sort="Chatzikyriakidou, Anthoula" uniqKey="Chatzikyriakidou A" first="Anthoula" last="Chatzikyriakidou">Anthoula Chatzikyriakidou</name><affiliation><nlm:aff id="A76">Department of Biology and Genetics, Faculty of Medicine, Aristotle University of Thessaloniki, Greece</nlm:aff></affiliation></author><author><name sortKey="Lambropoulos, Alexandros" sort="Lambropoulos, Alexandros" uniqKey="Lambropoulos A" first="Alexandros" last="Lambropoulos">Alexandros Lambropoulos</name><affiliation><nlm:aff id="A76">Department of Biology and Genetics, Faculty of Medicine, Aristotle University of Thessaloniki, Greece</nlm:aff></affiliation></author><author><name sortKey="Anastasopoulos, Eleftherios" sort="Anastasopoulos, Eleftherios" uniqKey="Anastasopoulos E" first="Eleftherios" last="Anastasopoulos">Eleftherios Anastasopoulos</name><affiliation><nlm:aff id="A75">Department of Ophthalmology, Faculty of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece</nlm:aff></affiliation></author><author><name sortKey="Coleman, Anne L" sort="Coleman, Anne L" uniqKey="Coleman A" first="Anne L" last="Coleman">Anne L. Coleman</name><affiliation><nlm:aff id="A77">Center for Community Outreach and Policy, Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 United States</nlm:aff></affiliation></author><author><name sortKey="Wilson, M Roy" sort="Wilson, M Roy" uniqKey="Wilson M" first="M Roy" last="Wilson">M Roy Wilson</name><affiliation><nlm:aff id="A78">Wayne State University, Detroit, 48202, United States</nlm:aff></affiliation></author><author><name sortKey="Rhee, Douglas J" sort="Rhee, Douglas J" uniqKey="Rhee D" first="Douglas J" last="Rhee">Douglas J. Rhee</name><affiliation><nlm:aff id="A79">Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America</nlm:aff></affiliation></author><author><name sortKey="Kang, Jae Hee" sort="Kang, Jae Hee" uniqKey="Kang J" first="Jae Hee" last="Kang">Jae Hee Kang</name><affiliation><nlm:aff id="A80">Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America</nlm:aff></affiliation></author><author><name sortKey="May Bolchakova, Inna" sort="May Bolchakova, Inna" uniqKey="May Bolchakova I" first="Inna" last="May-Bolchakova">Inna May-Bolchakova</name><affiliation><nlm:aff id="A81">Ophthalmology Department, Military Hospital Begin, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Heegaard, Steffen" sort="Heegaard, Steffen" uniqKey="Heegaard S" first="Steffen" last="Heegaard">Steffen Heegaard</name><affiliation><nlm:aff id="A82">Eye Pathology Institute, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A83">Department of Ophthalmology, Glostrup University Hospital, Glostrup, Denmark</nlm:aff></affiliation></author><author><name sortKey="Mori, Kazuhiko" sort="Mori, Kazuhiko" uniqKey="Mori K" first="Kazuhiko" last="Mori">Kazuhiko Mori</name><affiliation><nlm:aff id="A32">Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Alward, Wallace L M" sort="Alward, Wallace L M" uniqKey="Alward W" first="Wallace L. M." last="Alward">Wallace L. M. Alward</name><affiliation><nlm:aff id="A84">Stephen A. Wynn Institute for Vision Research, University of Iowa, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A85">Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City</nlm:aff></affiliation></author><author><name sortKey="Jonas, Jost B" sort="Jonas, Jost B" uniqKey="Jonas J" first="Jost B" last="Jonas">Jost B. Jonas</name><affiliation><nlm:aff id="A86">Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Xu, Liang" sort="Xu, Liang" uniqKey="Xu L" first="Liang" last="Xu">Liang Xu</name><affiliation><nlm:aff id="A24">Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China</nlm:aff></affiliation></author><author><name sortKey="Liebmann, Jeffrey M" sort="Liebmann, Jeffrey M" uniqKey="Liebmann J" first="Jeffrey M" last="Liebmann">Jeffrey M. Liebmann</name><affiliation><nlm:aff id="A87">New York University School of Medicine; Manhattan Eye, Ear and Throat Hospital, New York</nlm:aff></affiliation></author><author><name sortKey="Chowbay, Balram" sort="Chowbay, Balram" uniqKey="Chowbay B" first="Balram" last="Chowbay">Balram Chowbay</name><affiliation><nlm:aff id="A88">Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre of Singapore</nlm:aff></affiliation></author><author><name sortKey="Schaeffeler, Elke" sort="Schaeffeler, Elke" uniqKey="Schaeffeler E" first="Elke" last="Schaeffeler">Elke Schaeffeler</name><affiliation><nlm:aff id="A89">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, and University Tuebingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Schwab, Matthias" sort="Schwab, Matthias" uniqKey="Schwab M" first="Matthias" last="Schwab">Matthias Schwab</name><affiliation><nlm:aff id="A89">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, and University Tuebingen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A90">Department of Clinical Pharmacology, University Hospital, Tuebingen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A91">German Cancer Consortium (DKTK), German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Lerner, Fabian" sort="Lerner, Fabian" uniqKey="Lerner F" first="Fabian" last="Lerner">Fabian Lerner</name><affiliation><nlm:aff id="A92">Fundacion para el Estudio del Glaucoma, Marcelo T de Alvear 2010 - 2A Buenos Aires (C1122AAF) Argentina</nlm:aff></affiliation></author><author><name sortKey="Wang, Ningli" sort="Wang, Ningli" uniqKey="Wang N" first="Ningli" last="Wang">Ningli Wang</name><affiliation><nlm:aff id="A23">Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China</nlm:aff></affiliation></author><author><name sortKey="Yang, Zhenglin" sort="Yang, Zhenglin" uniqKey="Yang Z" first="Zhenglin" last="Yang">Zhenglin Yang</name><affiliation><nlm:aff id="A28">Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People’s Hospital, Chengdu, China</nlm:aff></affiliation><affiliation><nlm:aff id="A29">School of Medicine, University of Electronic Science and Technology of China, Chengdu, China</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, China</nlm:aff></affiliation></author><author><name sortKey="Frezzotti, Paolo" sort="Frezzotti, Paolo" uniqKey="Frezzotti P" first="Paolo" last="Frezzotti">Paolo Frezzotti</name><affiliation><nlm:aff id="A93">Department of Surgery, Section of Ophthalmology, University of Siena, Siena, Italy</nlm:aff></affiliation></author><author><name sortKey="Kinoshita, Shigeru" sort="Kinoshita, Shigeru" uniqKey="Kinoshita S" first="Shigeru" last="Kinoshita">Shigeru Kinoshita</name><affiliation><nlm:aff id="A32">Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Fingert, John H" sort="Fingert, John H" uniqKey="Fingert J" first="John H." last="Fingert">John H. Fingert</name><affiliation><nlm:aff id="A84">Stephen A. Wynn Institute for Vision Research, University of Iowa, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A85">Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City</nlm:aff></affiliation></author><author><name sortKey="Inatani, Masaru" sort="Inatani, Masaru" uniqKey="Inatani M" first="Masaru" last="Inatani">Masaru Inatani</name><affiliation><nlm:aff id="A94">Department of Ophthalmology, Faculty of Medical Science, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Eiheiji, Yoshida, Fukui, 910-1193, Japan</nlm:aff></affiliation></author><author><name sortKey="Tashiro, Kei" sort="Tashiro, Kei" uniqKey="Tashiro K" first="Kei" last="Tashiro">Kei Tashiro</name><affiliation><nlm:aff id="A31">Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Reis, Andre" sort="Reis, Andre" uniqKey="Reis A" first="André" last="Reis">André Reis</name><affiliation><nlm:aff id="A10">Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Edward, Deepak P" sort="Edward, Deepak P" uniqKey="Edward D" first="Deepak P." last="Edward">Deepak P. Edward</name><affiliation><nlm:aff id="A22">King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="A95">Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America</nlm:aff></affiliation></author><author><name sortKey="Pasquale, Louis R" sort="Pasquale, Louis R" uniqKey="Pasquale L" first="Louis R." last="Pasquale">Louis R. Pasquale</name><affiliation><nlm:aff id="A79">Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America</nlm:aff></affiliation><affiliation><nlm:aff id="A80">Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America</nlm:aff></affiliation></author><author><name sortKey="Kubota, Toshiaki" sort="Kubota, Toshiaki" uniqKey="Kubota T" first="Toshiaki" last="Kubota">Toshiaki Kubota</name><affiliation><nlm:aff id="A9">Department of Ophthalmology, Oita University Faculty of Medicine</nlm:aff></affiliation></author><author><name sortKey="Wiggs, Janey L" sort="Wiggs, Janey L" uniqKey="Wiggs J" first="Janey L." last="Wiggs">Janey L. Wiggs</name><affiliation><nlm:aff id="A79">Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America</nlm:aff></affiliation></author><author><name sortKey="Pasutto, Francesca" sort="Pasutto, Francesca" uniqKey="Pasutto F" first="Francesca" last="Pasutto">Francesca Pasutto</name><affiliation><nlm:aff id="A10">Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Topouzis, Fotis" sort="Topouzis, Fotis" uniqKey="Topouzis F" first="Fotis" last="Topouzis">Fotis Topouzis</name><affiliation><nlm:aff id="A75">Department of Ophthalmology, Faculty of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece</nlm:aff></affiliation></author><author><name sortKey="Dubina, Michael" sort="Dubina, Michael" uniqKey="Dubina M" first="Michael" last="Dubina">Michael Dubina</name><affiliation><nlm:aff id="A14">Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, 6/8 L’va Tolstogo Street, 197022 St. Petersburg, Russia</nlm:aff></affiliation><affiliation><nlm:aff id="A74">St. Petersburg Academic University, 8/3 Klopina Street, 194021 St. Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E." last="Craig">Jamie E. Craig</name><affiliation><nlm:aff id="A12">Department of Ophthalmology, Flinders University, Adelaide, SA, Australia</nlm:aff></affiliation></author><author><name sortKey="Yoshimura, Nagahisa" sort="Yoshimura, Nagahisa" uniqKey="Yoshimura N" first="Nagahisa" last="Yoshimura">Nagahisa Yoshimura</name><affiliation><nlm:aff id="A49">Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Sundaresan, Periasamy" sort="Sundaresan, Periasamy" uniqKey="Sundaresan P" first="Periasamy" last="Sundaresan">Periasamy Sundaresan</name><affiliation><nlm:aff id="A58">Department of Genetics, Aravind Medical Research Foundation, Madurai, India</nlm:aff></affiliation></author><author><name sortKey="John, Simon W M" sort="John, Simon W M" uniqKey="John S" first="Simon W. M." last="John">Simon W. M. John</name><affiliation><nlm:aff id="A11">The Howard Hughes Medical Institute, the Jackson Laboratory 600 Main Street, Bar Harbor, ME 04609</nlm:aff></affiliation></author><author><name sortKey="Ritch, Robert" sort="Ritch, Robert" uniqKey="Ritch R" first="Robert" last="Ritch">Robert Ritch</name><affiliation><nlm:aff id="A96">Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, United States of America</nlm:aff></affiliation></author><author><name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A" last="Hauser">Michael A. Hauser</name><affiliation><nlm:aff id="A6">Department of Ophthalmology, Duke University Eye Center, Durham, NC</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Department of Medicine, Duke University Medical Center, Durham, North Carolina</nlm:aff></affiliation></author><author><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><affiliation><nlm:aff id="A3">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25706626</idno><idno type="pmc">4605818</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605818</idno><idno type="RBID">PMC:4605818</idno><idno type="doi">10.1038/ng.3226</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002148</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002148</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A common variant mapping to <italic>CACNA1A</italic> is associated with susceptibility to Exfoliation syndrome</title><author><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Singapore National Eye Center, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</nlm:aff></affiliation></author><author><name sortKey="Ozaki, Mineo" sort="Ozaki, Mineo" uniqKey="Ozaki M" first="Mineo" last="Ozaki">Mineo Ozaki</name><affiliation><nlm:aff id="A4">Ozaki Eye Hospital, 1-15, Kamezaki, Hyuga, Miyazaki 883-0066 Japan</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Hayashi Eye Hospital, 4-23-35, Hakataekimae, Hakata-ku, Fukuoka, Japan</nlm:aff></affiliation></author><author><name sortKey="Mizoguchi, Takanori" sort="Mizoguchi, Takanori" uniqKey="Mizoguchi T" first="Takanori" last="Mizoguchi">Takanori Mizoguchi</name><affiliation><nlm:aff id="A5">Mizoguchi Eye Hospital, 6-13 Tawara-machi, Sasebo, Nagasaki, Japan 857-0016</nlm:aff></affiliation></author><author><name sortKey="Allingham, R Rand" sort="Allingham, R Rand" uniqKey="Allingham R" first="R Rand" last="Allingham">R Rand Allingham</name><affiliation><nlm:aff id="A6">Department of Ophthalmology, Duke University Eye Center, Durham, NC</nlm:aff></affiliation></author><author><name sortKey="Li, Zheng" sort="Li, Zheng" uniqKey="Li Z" first="Zheng" last="Li">Zheng Li</name><affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff></affiliation></author><author><name sortKey="Haripriya, Aravind" sort="Haripriya, Aravind" uniqKey="Haripriya A" first="Aravind" last="Haripriya">Aravind Haripriya</name><affiliation><nlm:aff id="A8">Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai, India</nlm:aff></affiliation></author><author><name sortKey="Nakano, Satoko" sort="Nakano, Satoko" uniqKey="Nakano S" first="Satoko" last="Nakano">Satoko Nakano</name><affiliation><nlm:aff id="A9">Department of Ophthalmology, Oita University Faculty of Medicine</nlm:aff></affiliation></author><author><name sortKey="Uebe, Steffen" sort="Uebe, Steffen" uniqKey="Uebe S" first="Steffen" last="Uebe">Steffen Uebe</name><affiliation><nlm:aff id="A10">Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Harder, Jeffrey M" sort="Harder, Jeffrey M" uniqKey="Harder J" first="Jeffrey M." last="Harder">Jeffrey M. Harder</name><affiliation><nlm:aff id="A11">The Howard Hughes Medical Institute, the Jackson Laboratory 600 Main Street, Bar Harbor, ME 04609</nlm:aff></affiliation></author><author><name sortKey="Chan, Anita S Y" sort="Chan, Anita S Y" uniqKey="Chan A" first="Anita S. Y." last="Chan">Anita S. Y. Chan</name><affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Singapore National Eye Center, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation></author><author><name sortKey="Lee, Mei Chin" sort="Lee, Mei Chin" uniqKey="Lee M" first="Mei Chin" last="Lee">Mei Chin Lee</name><affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation></author><author><name sortKey="Burdon, Kathryn P" sort="Burdon, Kathryn P" uniqKey="Burdon K" first="Kathryn P." last="Burdon">Kathryn P. Burdon</name><affiliation><nlm:aff id="A12">Department of Ophthalmology, Flinders University, Adelaide, SA, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Menzies Institute for Medical Research, University of Tasmania</nlm:aff></affiliation></author><author><name sortKey="Astakhov, Yury S" sort="Astakhov, Yury S" uniqKey="Astakhov Y" first="Yury S." last="Astakhov">Yury S. Astakhov</name><affiliation><nlm:aff id="A14">Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, 6/8 L’va Tolstogo Street, 197022 St. Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Abu Amero, Khaled K" sort="Abu Amero, Khaled K" uniqKey="Abu Amero K" first="Khaled K." last="Abu-Amero">Khaled K. Abu-Amero</name><affiliation><nlm:aff id="A15">Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Department of Ophthalmology, College of Medicine, University of Florida, Jacksonville, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Zenteno, Juan C" sort="Zenteno, Juan C" uniqKey="Zenteno J" first="Juan C." last="Zenteno">Juan C. Zenteno</name><affiliation><nlm:aff id="A17">Genetics Department, Institute of Ophthalmology “Conde de Valenciana”, Mexico</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Biochemistry Department, Faculty of Medicine, UNAM, Mexico City, Mexico</nlm:aff></affiliation></author><author><name sortKey="Nilgun, Yildirim" sort="Nilgun, Yildirim" uniqKey="Nilgun Y" first="Yildirim" last="Nilgün">Yildirim Nilgün</name><affiliation><nlm:aff id="A19">Department of Ophthalmology, Eskisehir Osmangazi University, Meselik, Eskisehir, Turkey</nlm:aff></affiliation></author><author><name sortKey="Zarnowski, Tomasz" sort="Zarnowski, Tomasz" uniqKey="Zarnowski T" first="Tomasz" last="Zarnowski">Tomasz Zarnowski</name><affiliation><nlm:aff id="A20">Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland, Chmielna 1, 20-079 Lublin, Poland</nlm:aff></affiliation></author><author><name sortKey="Pakravan, Mohammad" sort="Pakravan, Mohammad" uniqKey="Pakravan M" first="Mohammad" last="Pakravan">Mohammad Pakravan</name><affiliation><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Safieh, Leen Abu" sort="Safieh, Leen Abu" uniqKey="Safieh L" first="Leen Abu" last="Safieh">Leen Abu Safieh</name><affiliation><nlm:aff id="A22">King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Jia, Liyun" sort="Jia, Liyun" uniqKey="Jia L" first="Liyun" last="Jia">Liyun Jia</name><affiliation><nlm:aff id="A23">Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China</nlm:aff></affiliation></author><author><name sortKey="Wang, Ya Xing" sort="Wang, Ya Xing" uniqKey="Wang Y" first="Ya Xing" last="Wang">Ya Xing Wang</name><affiliation><nlm:aff id="A24">Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China</nlm:aff></affiliation></author><author><name sortKey="Williams, Susan" sort="Williams, Susan" uniqKey="Williams S" first="Susan" last="Williams">Susan Williams</name><affiliation><nlm:aff id="A25">Division of Ophthalmology, Department of Neurosciences, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff></affiliation></author><author><name sortKey="Paoli, Daniela" sort="Paoli, Daniela" uniqKey="Paoli D" first="Daniela" last="Paoli">Daniela Paoli</name><affiliation><nlm:aff id="A26">Department of Ophthalmology, Monfalcone Hospital, Gorizia, Italy</nlm:aff></affiliation></author><author><name sortKey="Schlottmann, Patricio G" sort="Schlottmann, Patricio G" uniqKey="Schlottmann P" first="Patricio G" last="Schlottmann">Patricio G. Schlottmann</name><affiliation><nlm:aff id="A27">Organización Médica de Investigación, Uruguay 725 – PB, Buenos Aires (C1015ABO) Argentina</nlm:aff></affiliation></author><author><name sortKey="Huang, Lulin" sort="Huang, Lulin" uniqKey="Huang L" first="Lulin" last="Huang">Lulin Huang</name><affiliation><nlm:aff id="A28">Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People’s Hospital, Chengdu, China</nlm:aff></affiliation><affiliation><nlm:aff id="A29">School of Medicine, University of Electronic Science and Technology of China, Chengdu, China</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, China</nlm:aff></affiliation></author><author><name sortKey="Sim, Kar Seng" sort="Sim, Kar Seng" uniqKey="Sim K" first="Kar Seng" last="Sim">Kar Seng Sim</name><affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff></affiliation></author><author><name sortKey="Foo, Jia Nee" sort="Foo, Jia Nee" uniqKey="Foo J" first="Jia Nee" last="Foo">Jia Nee Foo</name><affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff></affiliation></author><author><name sortKey="Nakano, Masakazu" sort="Nakano, Masakazu" uniqKey="Nakano M" first="Masakazu" last="Nakano">Masakazu Nakano</name><affiliation><nlm:aff id="A31">Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Ikeda, Yoko" sort="Ikeda, Yoko" uniqKey="Ikeda Y" first="Yoko" last="Ikeda">Yoko Ikeda</name><affiliation><nlm:aff id="A32">Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Kumar, Rajesh S" sort="Kumar, Rajesh S" uniqKey="Kumar R" first="Rajesh S" last="Kumar">Rajesh S. Kumar</name><affiliation><nlm:aff id="A33">Glaucoma services, Narayana Nethralaya Eye Hospital, 121/C, Chord Road, Rajajinagar, 1st R Block, Bangalore 560 010, India</nlm:aff></affiliation></author><author><name sortKey="Ueno, Morio" sort="Ueno, Morio" uniqKey="Ueno M" first="Morio" last="Ueno">Morio Ueno</name><affiliation><nlm:aff id="A32">Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Manabe, Shin Ichi" sort="Manabe, Shin Ichi" uniqKey="Manabe S" first="Shin-Ichi" last="Manabe">Shin-Ichi Manabe</name><affiliation><nlm:aff id="A34">Hayashi Eye Hospital, 4-23-35, Hakataekimae, Hakata-ku, Fukuoka, Japan</nlm:aff></affiliation></author><author><name sortKey="Hayashi, Ken" sort="Hayashi, Ken" uniqKey="Hayashi K" first="Ken" last="Hayashi">Ken Hayashi</name><affiliation><nlm:aff id="A34">Hayashi Eye Hospital, 4-23-35, Hakataekimae, Hakata-ku, Fukuoka, Japan</nlm:aff></affiliation></author><author><name sortKey="Kazama, Shigeyasu" sort="Kazama, Shigeyasu" uniqKey="Kazama S" first="Shigeyasu" last="Kazama">Shigeyasu Kazama</name><affiliation><nlm:aff id="A35">Shinjo Eye Clinic, 889-1,Mego, Simokitakatamachi, Miyazaki-shi, Miyazaki 880-0035,Japan</nlm:aff></affiliation></author><author><name sortKey="Ideta, Ryuichi" sort="Ideta, Ryuichi" uniqKey="Ideta R" first="Ryuichi" last="Ideta">Ryuichi Ideta</name><affiliation><nlm:aff id="A36">Ideta Eye Hospital, Kumamoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Mori, Yosai" sort="Mori, Yosai" uniqKey="Mori Y" first="Yosai" last="Mori">Yosai Mori</name><affiliation><nlm:aff id="A37">Miyata Eye Hospital, 6-3, Kurahara, Miyakonojo, Miyazaki 885-0051 Japan</nlm:aff></affiliation></author><author><name sortKey="Miyata, Kazunori" sort="Miyata, Kazunori" uniqKey="Miyata K" first="Kazunori" last="Miyata">Kazunori Miyata</name><affiliation><nlm:aff id="A37">Miyata Eye Hospital, 6-3, Kurahara, Miyakonojo, Miyazaki 885-0051 Japan</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan</nlm:aff></affiliation></author><author><name sortKey="Sugiyama, Kazuhisa" sort="Sugiyama, Kazuhisa" uniqKey="Sugiyama K" first="Kazuhisa" last="Sugiyama">Kazuhisa Sugiyama</name><affiliation><nlm:aff id="A39">Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan</nlm:aff></affiliation></author><author><name sortKey="Higashide, Tomomi" sort="Higashide, Tomomi" uniqKey="Higashide T" first="Tomomi" last="Higashide">Tomomi Higashide</name><affiliation><nlm:aff id="A39">Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan</nlm:aff></affiliation></author><author><name sortKey="Chihara, Etsuo" sort="Chihara, Etsuo" uniqKey="Chihara E" first="Etsuo" last="Chihara">Etsuo Chihara</name><affiliation><nlm:aff id="A40">Sensho-kai Eye Institute, Minamiyama 50-1, Iseda, Uji, Kyoto 611-0043, Japan</nlm:aff></affiliation></author><author><name sortKey="Inoue, Kenji" sort="Inoue, Kenji" uniqKey="Inoue K" first="Kenji" last="Inoue">Kenji Inoue</name><affiliation><nlm:aff id="A41">Inouye Eye Hospital, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Ishiko, Satoshi" sort="Ishiko, Satoshi" uniqKey="Ishiko S" first="Satoshi" last="Ishiko">Satoshi Ishiko</name><affiliation><nlm:aff id="A42">Department of Medicine and Engineering Combined Research Institute, Asahikawa Medical University, Asahikawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Yoshida, Akitoshi" sort="Yoshida, Akitoshi" uniqKey="Yoshida A" first="Akitoshi" last="Yoshida">Akitoshi Yoshida</name><affiliation><nlm:aff id="A43">Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Yanagi, Masahide" sort="Yanagi, Masahide" uniqKey="Yanagi M" first="Masahide" last="Yanagi">Masahide Yanagi</name><affiliation><nlm:aff id="A44">Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima, Japan</nlm:aff></affiliation></author><author><name sortKey="Kiuchi, Yoshiaki" sort="Kiuchi, Yoshiaki" uniqKey="Kiuchi Y" first="Yoshiaki" last="Kiuchi">Yoshiaki Kiuchi</name><affiliation><nlm:aff id="A44">Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima, Japan</nlm:aff></affiliation></author><author><name sortKey="Aihara, Makoto" sort="Aihara, Makoto" uniqKey="Aihara M" first="Makoto" last="Aihara">Makoto Aihara</name><affiliation><nlm:aff id="A45">Yotsuya Shirato Eye Clinic, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Ohashi, Tsutomu" sort="Ohashi, Tsutomu" uniqKey="Ohashi T" first="Tsutomu" last="Ohashi">Tsutomu Ohashi</name><affiliation><nlm:aff id="A46">Ohashi eye center, Kita1-1 Hondori6 Shiroishi-ku Sapporo 003-0027 Japan</nlm:aff></affiliation></author><author><name sortKey="Sakurai, Toshiya" sort="Sakurai, Toshiya" uniqKey="Sakurai T" first="Toshiya" last="Sakurai">Toshiya Sakurai</name><affiliation><nlm:aff id="A47">Tane Memorial Eye Hospital, Osaka</nlm:aff></affiliation></author><author><name sortKey="Sugimoto, Takako" sort="Sugimoto, Takako" uniqKey="Sugimoto T" first="Takako" last="Sugimoto">Takako Sugimoto</name><affiliation><nlm:aff id="A38">Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan</nlm:aff></affiliation></author><author><name sortKey="Chuman, Hideki" sort="Chuman, Hideki" uniqKey="Chuman H" first="Hideki" last="Chuman">Hideki Chuman</name><affiliation><nlm:aff id="A38">Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan</nlm:aff></affiliation></author><author><name sortKey="Matsuda, Fumihiko" sort="Matsuda, Fumihiko" uniqKey="Matsuda F" first="Fumihiko" last="Matsuda">Fumihiko Matsuda</name><affiliation><nlm:aff id="A48">Center for Genomic Medicine/Inserm U.852, Kyoto University Graduate School of Medicine, Kyoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Yamashiro, Kenji" sort="Yamashiro, Kenji" uniqKey="Yamashiro K" first="Kenji" last="Yamashiro">Kenji Yamashiro</name><affiliation><nlm:aff id="A49">Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Gotoh, Norimoto" sort="Gotoh, Norimoto" uniqKey="Gotoh N" first="Norimoto" last="Gotoh">Norimoto Gotoh</name><affiliation><nlm:aff id="A49">Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Miyake, Masahiro" sort="Miyake, Masahiro" uniqKey="Miyake M" first="Masahiro" last="Miyake">Masahiro Miyake</name><affiliation><nlm:aff id="A48">Center for Genomic Medicine/Inserm U.852, Kyoto University Graduate School of Medicine, Kyoto, Japan</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Astakhov, Sergei Y" sort="Astakhov, Sergei Y" uniqKey="Astakhov S" first="Sergei Y." last="Astakhov">Sergei Y. Astakhov</name><affiliation><nlm:aff id="A14">Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, 6/8 L’va Tolstogo Street, 197022 St. Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Osman, Essam A" sort="Osman, Essam A" uniqKey="Osman E" first="Essam A." last="Osman">Essam A. Osman</name><affiliation><nlm:aff id="A15">Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Al Obeidan, Saleh A" sort="Al Obeidan, Saleh A" uniqKey="Al Obeidan S" first="Saleh A." last="Al-Obeidan">Saleh A. Al-Obeidan</name><affiliation><nlm:aff id="A15">Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Owaidhah, Ohoud" sort="Owaidhah, Ohoud" uniqKey="Owaidhah O" first="Ohoud" last="Owaidhah">Ohoud Owaidhah</name><affiliation><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Al Jasim, Leyla" sort="Al Jasim, Leyla" uniqKey="Al Jasim L" first="Leyla" last="Al-Jasim">Leyla Al-Jasim</name><affiliation><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Al Shahwan, Sami" sort="Al Shahwan, Sami" uniqKey="Al Shahwan S" first="Sami" last="Al Shahwan">Sami Al Shahwan</name><affiliation><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Fogarty, Rhys A" sort="Fogarty, Rhys A" uniqKey="Fogarty R" first="Rhys A." last="Fogarty">Rhys A. Fogarty</name><affiliation><nlm:aff id="A12">Department of Ophthalmology, Flinders University, Adelaide, SA, Australia</nlm:aff></affiliation></author><author><name sortKey="Leo, Paul" sort="Leo, Paul" uniqKey="Leo P" first="Paul" last="Leo">Paul Leo</name><affiliation><nlm:aff id="A50">University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Qld, Australia</nlm:aff></affiliation></author><author><name sortKey="Yetkin, Yaz" sort="Yetkin, Yaz" uniqKey="Yetkin Y" first="Yaz" last="Yetkin">Yaz Yetkin</name><affiliation><nlm:aff id="A19">Department of Ophthalmology, Eskisehir Osmangazi University, Meselik, Eskisehir, Turkey</nlm:aff></affiliation></author><author><name sortKey="O Uz, Cilingir" sort="O Uz, Cilingir" uniqKey="O Uz C" first="Çilingir" last="O Uz">Çilingir O Uz</name><affiliation><nlm:aff id="A19">Department of Ophthalmology, Eskisehir Osmangazi University, Meselik, Eskisehir, Turkey</nlm:aff></affiliation></author><author><name sortKey="Kanavi, Mozhgan Rezaei" sort="Kanavi, Mozhgan Rezaei" uniqKey="Kanavi M" first="Mozhgan Rezaei" last="Kanavi">Mozhgan Rezaei Kanavi</name><affiliation><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Beni, Afsaneh Naderi" sort="Beni, Afsaneh Naderi" uniqKey="Beni A" first="Afsaneh Naderi" last="Beni">Afsaneh Naderi Beni</name><affiliation><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Yazdani, Shahin" sort="Yazdani, Shahin" uniqKey="Yazdani S" first="Shahin" last="Yazdani">Shahin Yazdani</name><affiliation><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Akopov, Evgeny L" sort="Akopov, Evgeny L" uniqKey="Akopov E" first="Evgeny L." last="Akopov">Evgeny L. Akopov</name><affiliation><nlm:aff id="A14">Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, 6/8 L’va Tolstogo Street, 197022 St. Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Toh, Kai Yee" sort="Toh, Kai Yee" uniqKey="Toh K" first="Kai-Yee" last="Toh">Kai-Yee Toh</name><affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff></affiliation></author><author><name sortKey="Howell, Gareth R" sort="Howell, Gareth R" uniqKey="Howell G" first="Gareth R" last="Howell">Gareth R. Howell</name><affiliation><nlm:aff id="A11">The Howard Hughes Medical Institute, the Jackson Laboratory 600 Main Street, Bar Harbor, ME 04609</nlm:aff></affiliation></author><author><name sortKey="Orr, Andrew C" sort="Orr, Andrew C" uniqKey="Orr A" first="Andrew C." last="Orr">Andrew C. Orr</name><affiliation><nlm:aff id="A51">Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Canada</nlm:aff></affiliation></author><author><name sortKey="Goh, Yufen" sort="Goh, Yufen" uniqKey="Goh Y" first="Yufen" last="Goh">Yufen Goh</name><affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff></affiliation></author><author><name sortKey="Meah, Wee Yang" sort="Meah, Wee Yang" uniqKey="Meah W" first="Wee Yang" last="Meah">Wee Yang Meah</name><affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff></affiliation></author><author><name sortKey="Peh, Su Qin" sort="Peh, Su Qin" uniqKey="Peh S" first="Su Qin" last="Peh">Su Qin Peh</name><affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff></affiliation></author><author><name sortKey="Kosior Jarecka, Ewa" sort="Kosior Jarecka, Ewa" uniqKey="Kosior Jarecka E" first="Ewa" last="Kosior-Jarecka">Ewa Kosior-Jarecka</name><affiliation><nlm:aff id="A20">Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland, Chmielna 1, 20-079 Lublin, Poland</nlm:aff></affiliation></author><author><name sortKey="Lukasik, Urszula" sort="Lukasik, Urszula" uniqKey="Lukasik U" first="Urszula" last="Lukasik">Urszula Lukasik</name><affiliation><nlm:aff id="A20">Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland, Chmielna 1, 20-079 Lublin, Poland</nlm:aff></affiliation></author><author><name sortKey="Krumbiegel, Mandy" sort="Krumbiegel, Mandy" uniqKey="Krumbiegel M" first="Mandy" last="Krumbiegel">Mandy Krumbiegel</name><affiliation><nlm:aff id="A10">Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Vithana, Eranga N" sort="Vithana, Eranga N" uniqKey="Vithana E" first="Eranga N" last="Vithana">Eranga N. Vithana</name><affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation></author><author><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien Yin" last="Wong">Tien Yin Wong</name><affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Singapore National Eye Center, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</nlm:aff></affiliation></author><author><name sortKey="Liu, Yutao" sort="Liu, Yutao" uniqKey="Liu Y" first="Yutao" last="Liu">Yutao Liu</name><affiliation><nlm:aff id="A52">Department of Medicine, Duke University Medical Center, Durham, North Carolina</nlm:aff></affiliation><affiliation><nlm:aff id="A53">Department of Cellular Biology and Anatomy, Georgia Regents University, Augusta, Georgia</nlm:aff></affiliation></author><author><name sortKey="Ashley Koch, Allison E" sort="Ashley Koch, Allison E" uniqKey="Ashley Koch A" first="Allison E." last="Ashley Koch">Allison E. Ashley Koch</name><affiliation><nlm:aff id="A52">Department of Medicine, Duke University Medical Center, Durham, North Carolina</nlm:aff></affiliation></author><author><name sortKey="Challa, Pratap" sort="Challa, Pratap" uniqKey="Challa P" first="Pratap" last="Challa">Pratap Challa</name><affiliation><nlm:aff id="A6">Department of Ophthalmology, Duke University Eye Center, Durham, NC</nlm:aff></affiliation></author><author><name sortKey="Rautenbach, Robyn M" sort="Rautenbach, Robyn M" uniqKey="Rautenbach R" first="Robyn M" last="Rautenbach">Robyn M. Rautenbach</name><affiliation><nlm:aff id="A54">Division of Ophthalmology, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A." last="Mackey">David A. Mackey</name><affiliation><nlm:aff id="A55">Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Australia</nlm:aff></affiliation></author><author><name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W" last="Hewitt">Alex W. Hewitt</name><affiliation><nlm:aff id="A13">Menzies Institute for Medical Research, University of Tasmania</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name><affiliation><nlm:aff id="A57">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, NSW Australia</nlm:aff></affiliation></author><author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name><affiliation><nlm:aff id="A57">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, NSW Australia</nlm:aff></affiliation></author><author><name sortKey="Ziskind, Ari" sort="Ziskind, Ari" uniqKey="Ziskind A" first="Ari" last="Ziskind">Ari Ziskind</name><affiliation><nlm:aff id="A54">Division of Ophthalmology, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Carmichael, Trevor" sort="Carmichael, Trevor" uniqKey="Carmichael T" first="Trevor" last="Carmichael">Trevor Carmichael</name><affiliation><nlm:aff id="A25">Division of Ophthalmology, Department of Neurosciences, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff></affiliation></author><author><name sortKey="Ramakrishnan, Rangappa" sort="Ramakrishnan, Rangappa" uniqKey="Ramakrishnan R" first="Rangappa" last="Ramakrishnan">Rangappa Ramakrishnan</name><affiliation><nlm:aff id="A8">Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai, India</nlm:aff></affiliation></author><author><name sortKey="Narendran, Kalpana" sort="Narendran, Kalpana" uniqKey="Narendran K" first="Kalpana" last="Narendran">Kalpana Narendran</name><affiliation><nlm:aff id="A8">Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai, India</nlm:aff></affiliation></author><author><name sortKey="Venkatesh, Rangaraj" sort="Venkatesh, Rangaraj" uniqKey="Venkatesh R" first="Rangaraj" last="Venkatesh">Rangaraj Venkatesh</name><affiliation><nlm:aff id="A8">Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai, India</nlm:aff></affiliation></author><author><name sortKey="Vijayan, Saravanan" sort="Vijayan, Saravanan" uniqKey="Vijayan S" first="Saravanan" last="Vijayan">Saravanan Vijayan</name><affiliation><nlm:aff id="A58">Department of Genetics, Aravind Medical Research Foundation, Madurai, India</nlm:aff></affiliation></author><author><name sortKey="Zhao, Peiquan" sort="Zhao, Peiquan" uniqKey="Zhao P" first="Peiquan" last="Zhao">Peiquan Zhao</name><affiliation><nlm:aff id="A59">Department of Ophthalmology, Xin Hua Hospital affiliated to Shanghai Jiao Tong University, School of Medicine, No. 1665, Kongjiang Road, Shanghai 200092, China</nlm:aff></affiliation></author><author><name sortKey="Chen, Xueyi" sort="Chen, Xueyi" uniqKey="Chen X" first="Xueyi" last="Chen">Xueyi Chen</name><affiliation><nlm:aff id="A60">Department of Ophthalmology, the First Affiliated Hospital of Xinjiang Medical University, Urumchi 830054, Xinjiang Uygur Autonomous Region, China</nlm:aff></affiliation></author><author><name sortKey="Guadarrama Vallejo, Dalia" sort="Guadarrama Vallejo, Dalia" uniqKey="Guadarrama Vallejo D" first="Dalia" last="Guadarrama-Vallejo">Dalia Guadarrama-Vallejo</name><affiliation><nlm:aff id="A17">Genetics Department, Institute of Ophthalmology “Conde de Valenciana”, Mexico</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Biochemistry Department, Faculty of Medicine, UNAM, Mexico City, Mexico</nlm:aff></affiliation></author><author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching Yu" last="Cheng">Ching Yu Cheng</name><affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</nlm:aff></affiliation></author><author><name sortKey="Perera, Shamira A" sort="Perera, Shamira A" uniqKey="Perera S" first="Shamira A" last="Perera">Shamira A. Perera</name><affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Singapore National Eye Center, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation></author><author><name sortKey="Husain, Rahat" sort="Husain, Rahat" uniqKey="Husain R" first="Rahat" last="Husain">Rahat Husain</name><affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Singapore National Eye Center, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation></author><author><name sortKey="Ho, Su Ling" sort="Ho, Su Ling" uniqKey="Ho S" first="Su-Ling" last="Ho">Su-Ling Ho</name><affiliation><nlm:aff id="A61">National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore</nlm:aff></affiliation></author><author><name sortKey="Welge Luessen, Ulrich Christoph" sort="Welge Luessen, Ulrich Christoph" uniqKey="Welge Luessen U" first="Ulrich-Christoph" last="Welge-Luessen">Ulrich-Christoph Welge-Luessen</name><affiliation><nlm:aff id="A62">Department of Ophthalmology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Mardin, Christian" sort="Mardin, Christian" uniqKey="Mardin C" first="Christian" last="Mardin">Christian Mardin</name><affiliation><nlm:aff id="A62">Department of Ophthalmology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Schloetzer Schrehardt, Ursula" sort="Schloetzer Schrehardt, Ursula" uniqKey="Schloetzer Schrehardt U" first="Ursula" last="Schloetzer-Schrehardt">Ursula Schloetzer-Schrehardt</name><affiliation><nlm:aff id="A62">Department of Ophthalmology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hillmer, Axel M" sort="Hillmer, Axel M" uniqKey="Hillmer A" first="Axel M." last="Hillmer">Axel M. Hillmer</name><affiliation><nlm:aff id="A63">Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore</nlm:aff></affiliation></author><author><name sortKey="Herms, Stefan" sort="Herms, Stefan" uniqKey="Herms S" first="Stefan" last="Herms">Stefan Herms</name><affiliation><nlm:aff id="A64">Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Division of Medical Genetics, University Hospital, Basel, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Human Genetics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Moebus, Susanne" sort="Moebus, Susanne" uniqKey="Moebus S" first="Susanne" last="Moebus">Susanne Moebus</name><affiliation><nlm:aff id="A68">Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name><affiliation><nlm:aff id="A64">Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Weisschuh, Nicole" sort="Weisschuh, Nicole" uniqKey="Weisschuh N" first="Nicole" last="Weisschuh">Nicole Weisschuh</name><affiliation><nlm:aff id="A69">University Eye Hospital, Wuerzburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Shetty, Rohit" sort="Shetty, Rohit" uniqKey="Shetty R" first="Rohit" last="Shetty">Rohit Shetty</name><affiliation><nlm:aff id="A33">Glaucoma services, Narayana Nethralaya Eye Hospital, 121/C, Chord Road, Rajajinagar, 1st R Block, Bangalore 560 010, India</nlm:aff></affiliation></author><author><name sortKey="Ghosh, Arkasubhra" sort="Ghosh, Arkasubhra" uniqKey="Ghosh A" first="Arkasubhra" last="Ghosh">Arkasubhra Ghosh</name><affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff></affiliation><affiliation><nlm:aff id="A70">Genes, Repair and Regeneration in Ophthalmic Workstation Research Lab, Narayana Nethralaya Foundation, Bangalore, India</nlm:aff></affiliation></author><author><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik Ying" last="Teo">Yik Ying Teo</name><affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="A71">Saw Swee Hock School of Public Health, National University of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Brown, Matthew A" sort="Brown, Matthew A" uniqKey="Brown M" first="Matthew A" last="Brown">Matthew A. Brown</name><affiliation><nlm:aff id="A50">University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Qld, Australia</nlm:aff></affiliation></author><author><name sortKey="Lischinsky, Ignacio" sort="Lischinsky, Ignacio" uniqKey="Lischinsky I" first="Ignacio" last="Lischinsky">Ignacio Lischinsky</name><affiliation><nlm:aff id="A72">Centro Oftalmologico Lischinsky, Junin 692, Tucuman (4000) – Argentina</nlm:aff></affiliation></author><author><name sortKey="Crowston, Jonathan G" sort="Crowston, Jonathan G" uniqKey="Crowston J" first="Jonathan G" last="Crowston">Jonathan G. Crowston</name><affiliation><nlm:aff id="A56">Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Department of Ophthalmology, University of Melbourne</nlm:aff></affiliation></author><author><name sortKey="Coote, Michael" sort="Coote, Michael" uniqKey="Coote M" first="Michael" last="Coote">Michael Coote</name><affiliation><nlm:aff id="A56">Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Department of Ophthalmology, University of Melbourne</nlm:aff></affiliation></author><author><name sortKey="Zhao, Bowen" sort="Zhao, Bowen" uniqKey="Zhao B" first="Bowen" last="Zhao">Bowen Zhao</name><affiliation><nlm:aff id="A22">King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Sang, Jinghong" sort="Sang, Jinghong" uniqKey="Sang J" first="Jinghong" last="Sang">Jinghong Sang</name><affiliation><nlm:aff id="A23">Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China</nlm:aff></affiliation></author><author><name sortKey="Zhang, Nihong" sort="Zhang, Nihong" uniqKey="Zhang N" first="Nihong" last="Zhang">Nihong Zhang</name><affiliation><nlm:aff id="A23">Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China</nlm:aff></affiliation></author><author><name sortKey="You, Qisheng" sort="You, Qisheng" uniqKey="You Q" first="Qisheng" last="You">Qisheng You</name><affiliation><nlm:aff id="A24">Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China</nlm:aff></affiliation></author><author><name sortKey="Vysochinskaya, Vera" sort="Vysochinskaya, Vera" uniqKey="Vysochinskaya V" first="Vera" last="Vysochinskaya">Vera Vysochinskaya</name><affiliation><nlm:aff id="A74">St. Petersburg Academic University, 8/3 Klopina Street, 194021 St. Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Founti, Panayiota" sort="Founti, Panayiota" uniqKey="Founti P" first="Panayiota" last="Founti">Panayiota Founti</name><affiliation><nlm:aff id="A75">Department of Ophthalmology, Faculty of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece</nlm:aff></affiliation></author><author><name sortKey="Chatzikyriakidou, Anthoula" sort="Chatzikyriakidou, Anthoula" uniqKey="Chatzikyriakidou A" first="Anthoula" last="Chatzikyriakidou">Anthoula Chatzikyriakidou</name><affiliation><nlm:aff id="A76">Department of Biology and Genetics, Faculty of Medicine, Aristotle University of Thessaloniki, Greece</nlm:aff></affiliation></author><author><name sortKey="Lambropoulos, Alexandros" sort="Lambropoulos, Alexandros" uniqKey="Lambropoulos A" first="Alexandros" last="Lambropoulos">Alexandros Lambropoulos</name><affiliation><nlm:aff id="A76">Department of Biology and Genetics, Faculty of Medicine, Aristotle University of Thessaloniki, Greece</nlm:aff></affiliation></author><author><name sortKey="Anastasopoulos, Eleftherios" sort="Anastasopoulos, Eleftherios" uniqKey="Anastasopoulos E" first="Eleftherios" last="Anastasopoulos">Eleftherios Anastasopoulos</name><affiliation><nlm:aff id="A75">Department of Ophthalmology, Faculty of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece</nlm:aff></affiliation></author><author><name sortKey="Coleman, Anne L" sort="Coleman, Anne L" uniqKey="Coleman A" first="Anne L" last="Coleman">Anne L. Coleman</name><affiliation><nlm:aff id="A77">Center for Community Outreach and Policy, Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 United States</nlm:aff></affiliation></author><author><name sortKey="Wilson, M Roy" sort="Wilson, M Roy" uniqKey="Wilson M" first="M Roy" last="Wilson">M Roy Wilson</name><affiliation><nlm:aff id="A78">Wayne State University, Detroit, 48202, United States</nlm:aff></affiliation></author><author><name sortKey="Rhee, Douglas J" sort="Rhee, Douglas J" uniqKey="Rhee D" first="Douglas J" last="Rhee">Douglas J. Rhee</name><affiliation><nlm:aff id="A79">Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America</nlm:aff></affiliation></author><author><name sortKey="Kang, Jae Hee" sort="Kang, Jae Hee" uniqKey="Kang J" first="Jae Hee" last="Kang">Jae Hee Kang</name><affiliation><nlm:aff id="A80">Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America</nlm:aff></affiliation></author><author><name sortKey="May Bolchakova, Inna" sort="May Bolchakova, Inna" uniqKey="May Bolchakova I" first="Inna" last="May-Bolchakova">Inna May-Bolchakova</name><affiliation><nlm:aff id="A81">Ophthalmology Department, Military Hospital Begin, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Heegaard, Steffen" sort="Heegaard, Steffen" uniqKey="Heegaard S" first="Steffen" last="Heegaard">Steffen Heegaard</name><affiliation><nlm:aff id="A82">Eye Pathology Institute, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A83">Department of Ophthalmology, Glostrup University Hospital, Glostrup, Denmark</nlm:aff></affiliation></author><author><name sortKey="Mori, Kazuhiko" sort="Mori, Kazuhiko" uniqKey="Mori K" first="Kazuhiko" last="Mori">Kazuhiko Mori</name><affiliation><nlm:aff id="A32">Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Alward, Wallace L M" sort="Alward, Wallace L M" uniqKey="Alward W" first="Wallace L. M." last="Alward">Wallace L. M. Alward</name><affiliation><nlm:aff id="A84">Stephen A. Wynn Institute for Vision Research, University of Iowa, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A85">Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City</nlm:aff></affiliation></author><author><name sortKey="Jonas, Jost B" sort="Jonas, Jost B" uniqKey="Jonas J" first="Jost B" last="Jonas">Jost B. Jonas</name><affiliation><nlm:aff id="A86">Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Xu, Liang" sort="Xu, Liang" uniqKey="Xu L" first="Liang" last="Xu">Liang Xu</name><affiliation><nlm:aff id="A24">Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China</nlm:aff></affiliation></author><author><name sortKey="Liebmann, Jeffrey M" sort="Liebmann, Jeffrey M" uniqKey="Liebmann J" first="Jeffrey M" last="Liebmann">Jeffrey M. Liebmann</name><affiliation><nlm:aff id="A87">New York University School of Medicine; Manhattan Eye, Ear and Throat Hospital, New York</nlm:aff></affiliation></author><author><name sortKey="Chowbay, Balram" sort="Chowbay, Balram" uniqKey="Chowbay B" first="Balram" last="Chowbay">Balram Chowbay</name><affiliation><nlm:aff id="A88">Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre of Singapore</nlm:aff></affiliation></author><author><name sortKey="Schaeffeler, Elke" sort="Schaeffeler, Elke" uniqKey="Schaeffeler E" first="Elke" last="Schaeffeler">Elke Schaeffeler</name><affiliation><nlm:aff id="A89">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, and University Tuebingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Schwab, Matthias" sort="Schwab, Matthias" uniqKey="Schwab M" first="Matthias" last="Schwab">Matthias Schwab</name><affiliation><nlm:aff id="A89">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, and University Tuebingen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A90">Department of Clinical Pharmacology, University Hospital, Tuebingen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A91">German Cancer Consortium (DKTK), German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Lerner, Fabian" sort="Lerner, Fabian" uniqKey="Lerner F" first="Fabian" last="Lerner">Fabian Lerner</name><affiliation><nlm:aff id="A92">Fundacion para el Estudio del Glaucoma, Marcelo T de Alvear 2010 - 2A Buenos Aires (C1122AAF) Argentina</nlm:aff></affiliation></author><author><name sortKey="Wang, Ningli" sort="Wang, Ningli" uniqKey="Wang N" first="Ningli" last="Wang">Ningli Wang</name><affiliation><nlm:aff id="A23">Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China</nlm:aff></affiliation></author><author><name sortKey="Yang, Zhenglin" sort="Yang, Zhenglin" uniqKey="Yang Z" first="Zhenglin" last="Yang">Zhenglin Yang</name><affiliation><nlm:aff id="A28">Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People’s Hospital, Chengdu, China</nlm:aff></affiliation><affiliation><nlm:aff id="A29">School of Medicine, University of Electronic Science and Technology of China, Chengdu, China</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, China</nlm:aff></affiliation></author><author><name sortKey="Frezzotti, Paolo" sort="Frezzotti, Paolo" uniqKey="Frezzotti P" first="Paolo" last="Frezzotti">Paolo Frezzotti</name><affiliation><nlm:aff id="A93">Department of Surgery, Section of Ophthalmology, University of Siena, Siena, Italy</nlm:aff></affiliation></author><author><name sortKey="Kinoshita, Shigeru" sort="Kinoshita, Shigeru" uniqKey="Kinoshita S" first="Shigeru" last="Kinoshita">Shigeru Kinoshita</name><affiliation><nlm:aff id="A32">Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Fingert, John H" sort="Fingert, John H" uniqKey="Fingert J" first="John H." last="Fingert">John H. Fingert</name><affiliation><nlm:aff id="A84">Stephen A. Wynn Institute for Vision Research, University of Iowa, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A85">Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City</nlm:aff></affiliation></author><author><name sortKey="Inatani, Masaru" sort="Inatani, Masaru" uniqKey="Inatani M" first="Masaru" last="Inatani">Masaru Inatani</name><affiliation><nlm:aff id="A94">Department of Ophthalmology, Faculty of Medical Science, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Eiheiji, Yoshida, Fukui, 910-1193, Japan</nlm:aff></affiliation></author><author><name sortKey="Tashiro, Kei" sort="Tashiro, Kei" uniqKey="Tashiro K" first="Kei" last="Tashiro">Kei Tashiro</name><affiliation><nlm:aff id="A31">Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Reis, Andre" sort="Reis, Andre" uniqKey="Reis A" first="André" last="Reis">André Reis</name><affiliation><nlm:aff id="A10">Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Edward, Deepak P" sort="Edward, Deepak P" uniqKey="Edward D" first="Deepak P." last="Edward">Deepak P. Edward</name><affiliation><nlm:aff id="A22">King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="A95">Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America</nlm:aff></affiliation></author><author><name sortKey="Pasquale, Louis R" sort="Pasquale, Louis R" uniqKey="Pasquale L" first="Louis R." last="Pasquale">Louis R. Pasquale</name><affiliation><nlm:aff id="A79">Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America</nlm:aff></affiliation><affiliation><nlm:aff id="A80">Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America</nlm:aff></affiliation></author><author><name sortKey="Kubota, Toshiaki" sort="Kubota, Toshiaki" uniqKey="Kubota T" first="Toshiaki" last="Kubota">Toshiaki Kubota</name><affiliation><nlm:aff id="A9">Department of Ophthalmology, Oita University Faculty of Medicine</nlm:aff></affiliation></author><author><name sortKey="Wiggs, Janey L" sort="Wiggs, Janey L" uniqKey="Wiggs J" first="Janey L." last="Wiggs">Janey L. Wiggs</name><affiliation><nlm:aff id="A79">Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America</nlm:aff></affiliation></author><author><name sortKey="Pasutto, Francesca" sort="Pasutto, Francesca" uniqKey="Pasutto F" first="Francesca" last="Pasutto">Francesca Pasutto</name><affiliation><nlm:aff id="A10">Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Topouzis, Fotis" sort="Topouzis, Fotis" uniqKey="Topouzis F" first="Fotis" last="Topouzis">Fotis Topouzis</name><affiliation><nlm:aff id="A75">Department of Ophthalmology, Faculty of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece</nlm:aff></affiliation></author><author><name sortKey="Dubina, Michael" sort="Dubina, Michael" uniqKey="Dubina M" first="Michael" last="Dubina">Michael Dubina</name><affiliation><nlm:aff id="A14">Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, 6/8 L’va Tolstogo Street, 197022 St. Petersburg, Russia</nlm:aff></affiliation><affiliation><nlm:aff id="A74">St. Petersburg Academic University, 8/3 Klopina Street, 194021 St. Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E." last="Craig">Jamie E. Craig</name><affiliation><nlm:aff id="A12">Department of Ophthalmology, Flinders University, Adelaide, SA, Australia</nlm:aff></affiliation></author><author><name sortKey="Yoshimura, Nagahisa" sort="Yoshimura, Nagahisa" uniqKey="Yoshimura N" first="Nagahisa" last="Yoshimura">Nagahisa Yoshimura</name><affiliation><nlm:aff id="A49">Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Sundaresan, Periasamy" sort="Sundaresan, Periasamy" uniqKey="Sundaresan P" first="Periasamy" last="Sundaresan">Periasamy Sundaresan</name><affiliation><nlm:aff id="A58">Department of Genetics, Aravind Medical Research Foundation, Madurai, India</nlm:aff></affiliation></author><author><name sortKey="John, Simon W M" sort="John, Simon W M" uniqKey="John S" first="Simon W. M." last="John">Simon W. M. John</name><affiliation><nlm:aff id="A11">The Howard Hughes Medical Institute, the Jackson Laboratory 600 Main Street, Bar Harbor, ME 04609</nlm:aff></affiliation></author><author><name sortKey="Ritch, Robert" sort="Ritch, Robert" uniqKey="Ritch R" first="Robert" last="Ritch">Robert Ritch</name><affiliation><nlm:aff id="A96">Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, United States of America</nlm:aff></affiliation></author><author><name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A" last="Hauser">Michael A. Hauser</name><affiliation><nlm:aff id="A6">Department of Ophthalmology, Duke University Eye Center, Durham, NC</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Department of Medicine, Duke University Medical Center, Durham, North Carolina</nlm:aff></affiliation></author><author><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><affiliation><nlm:aff id="A3">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Exfoliation syndrome (XFS) is the commonest recognizable cause of open angle glaucoma world-wide. To better understand the etiology of XFS, we conducted a genome-wide association study (GWAS) on 1,484 patients and 1,188 controls from Japan, and followed up the most significant findings on a further 6,901 patients and 20,727 controls from 17 countries across 6 continents. We discovered a significant association between a new locus (<italic>CACNA1A</italic> rs4926244) and increased susceptibility to XFS (Odds ratio [OR] = 1.16, <italic>P</italic> = 3.36 × 10<sup>−11</sup>). Although overwhelming association at the <italic>LOXL1</italic> locus was confirmed, the key SNP marker (<italic>LOXL1</italic> rs4886776) demonstrated allelic reversal depending on ethnic grouping (In Japanese: OR<sub>A-allele</sub>= 9.87, <italic>P</italic> = 2.13 × 10<sup>−217</sup>; In non-Japanese: OR<sub>A-allele</sub>= 0.49, <italic>P</italic> = 2.35 × 10<sup>−31</sup>). Our findings represent the first genetic locus outside of <italic>LOXL1</italic> which surpasses genome-wide significance for XFS, and provides insight into the biology and pathogenesis of the disease.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id><journal-id journal-id-type="pubmed-jr-id">2419</journal-id><journal-id journal-id-type="nlm-ta">Nat Genet</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Genet.</journal-id><journal-title-group><journal-title>Nature genetics</journal-title></journal-title-group><issn pub-type="ppub">1061-4036</issn><issn pub-type="epub">1546-1718</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25706626</article-id><article-id pub-id-type="pmc">4605818</article-id><article-id pub-id-type="doi">10.1038/ng.3226</article-id><article-id pub-id-type="manuscript">NIHMS677372</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>A common variant mapping to <italic>CACNA1A</italic> is associated with susceptibility to Exfoliation syndrome</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Aung</surname><given-names>Tin</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Ozaki</surname><given-names>Mineo</given-names></name><xref rid="FN2" ref-type="author-notes">*</xref><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A34">34</xref></contrib><contrib contrib-type="author"><name><surname>Mizoguchi</surname><given-names>Takanori</given-names></name><xref rid="FN2" ref-type="author-notes">*</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Allingham</surname><given-names>R Rand</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Zheng</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Haripriya</surname><given-names>Aravind</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Nakano</surname><given-names>Satoko</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Uebe</surname><given-names>Steffen</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Harder</surname><given-names>Jeffrey M.</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Chan</surname><given-names>Anita S.Y.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Mei Chin</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Burdon</surname><given-names>Kathryn P.</given-names></name><xref ref-type="aff" rid="A12">12</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Astakhov</surname><given-names>Yury S.</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Abu-Amero</surname><given-names>Khaled K.</given-names></name><xref ref-type="aff" rid="A15">15</xref><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Zenteno</surname><given-names>Juan C.</given-names></name><xref ref-type="aff" rid="A17">17</xref><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Nilgün</surname><given-names>Yildirim</given-names></name><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Zarnowski</surname><given-names>Tomasz</given-names></name><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Pakravan</surname><given-names>Mohammad</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Safieh</surname><given-names>Leen Abu</given-names></name><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Jia</surname><given-names>Liyun</given-names></name><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Ya Xing</given-names></name><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Williams</surname><given-names>Susan</given-names></name><xref ref-type="aff" rid="A25">25</xref></contrib><contrib contrib-type="author"><name><surname>Paoli</surname><given-names>Daniela</given-names></name><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Schlottmann</surname><given-names>Patricio G</given-names></name><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Lulin</given-names></name><xref ref-type="aff" rid="A28">28</xref><xref ref-type="aff" rid="A29">29</xref><xref ref-type="aff" rid="A30">30</xref></contrib><contrib contrib-type="author"><name><surname>Sim</surname><given-names>Kar Seng</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Foo</surname><given-names>Jia Nee</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Nakano</surname><given-names>Masakazu</given-names></name><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>Ikeda</surname><given-names>Yoko</given-names></name><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Kumar</surname><given-names>Rajesh S</given-names></name><xref ref-type="aff" rid="A33">33</xref></contrib><contrib contrib-type="author"><name><surname>Ueno</surname><given-names>Morio</given-names></name><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Manabe</surname><given-names>Shin-ichi</given-names></name><xref ref-type="aff" rid="A34">34</xref></contrib><contrib contrib-type="author"><name><surname>Hayashi</surname><given-names>Ken</given-names></name><xref ref-type="aff" rid="A34">34</xref></contrib><contrib contrib-type="author"><name><surname>Kazama</surname><given-names>Shigeyasu</given-names></name><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Ideta</surname><given-names>Ryuichi</given-names></name><xref ref-type="aff" rid="A36">36</xref></contrib><contrib contrib-type="author"><name><surname>Mori</surname><given-names>Yosai</given-names></name><xref ref-type="aff" rid="A37">37</xref></contrib><contrib contrib-type="author"><name><surname>Miyata</surname><given-names>Kazunori</given-names></name><xref ref-type="aff" rid="A37">37</xref><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Sugiyama</surname><given-names>Kazuhisa</given-names></name><xref ref-type="aff" rid="A39">39</xref></contrib><contrib contrib-type="author"><name><surname>Higashide</surname><given-names>Tomomi</given-names></name><xref ref-type="aff" rid="A39">39</xref></contrib><contrib contrib-type="author"><name><surname>Chihara</surname><given-names>Etsuo</given-names></name><xref ref-type="aff" rid="A40">40</xref></contrib><contrib contrib-type="author"><name><surname>Inoue</surname><given-names>Kenji</given-names></name><xref ref-type="aff" rid="A41">41</xref></contrib><contrib contrib-type="author"><name><surname>Ishiko</surname><given-names>Satoshi</given-names></name><xref ref-type="aff" rid="A42">42</xref></contrib><contrib contrib-type="author"><name><surname>Yoshida</surname><given-names>Akitoshi</given-names></name><xref ref-type="aff" rid="A43">43</xref></contrib><contrib contrib-type="author"><name><surname>Yanagi</surname><given-names>Masahide</given-names></name><xref ref-type="aff" rid="A44">44</xref></contrib><contrib contrib-type="author"><name><surname>Kiuchi</surname><given-names>Yoshiaki</given-names></name><xref ref-type="aff" rid="A44">44</xref></contrib><contrib contrib-type="author"><name><surname>Aihara</surname><given-names>Makoto</given-names></name><xref ref-type="aff" rid="A45">45</xref></contrib><contrib contrib-type="author"><name><surname>Ohashi</surname><given-names>Tsutomu</given-names></name><xref ref-type="aff" rid="A46">46</xref></contrib><contrib contrib-type="author"><name><surname>Sakurai</surname><given-names>Toshiya</given-names></name><xref ref-type="aff" rid="A47">47</xref></contrib><contrib contrib-type="author"><name><surname>Sugimoto</surname><given-names>Takako</given-names></name><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Chuman</surname><given-names>Hideki</given-names></name><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Matsuda</surname><given-names>Fumihiko</given-names></name><xref ref-type="aff" rid="A48">48</xref></contrib><contrib contrib-type="author"><name><surname>Yamashiro</surname><given-names>Kenji</given-names></name><xref ref-type="aff" rid="A49">49</xref></contrib><contrib contrib-type="author"><name><surname>Gotoh</surname><given-names>Norimoto</given-names></name><xref ref-type="aff" rid="A49">49</xref></contrib><contrib contrib-type="author"><name><surname>Miyake</surname><given-names>Masahiro</given-names></name><xref ref-type="aff" rid="A48">48</xref><xref ref-type="aff" rid="A49">49</xref></contrib><contrib contrib-type="author"><name><surname>Astakhov</surname><given-names>Sergei Y.</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Osman</surname><given-names>Essam A.</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Al-Obeidan</surname><given-names>Saleh A.</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Owaidhah</surname><given-names>Ohoud</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Al-Jasim</surname><given-names>Leyla</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Al Shahwan</surname><given-names>Sami</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Fogarty</surname><given-names>Rhys A.</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Leo</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="A50">50</xref></contrib><contrib contrib-type="author"><name><surname>Yetkin</surname><given-names>Yaz</given-names></name><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Oğuz</surname><given-names>Çilingir</given-names></name><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Kanavi</surname><given-names>Mozhgan Rezaei</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Beni</surname><given-names>Afsaneh Naderi</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Yazdani</surname><given-names>Shahin</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Akopov</surname><given-names>Evgeny L.</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Toh</surname><given-names>Kai-Yee</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Howell</surname><given-names>Gareth R</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Orr</surname><given-names>Andrew C.</given-names></name><xref ref-type="aff" rid="A51">51</xref></contrib><contrib contrib-type="author"><name><surname>Goh</surname><given-names>Yufen</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Meah</surname><given-names>Wee Yang</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Peh</surname><given-names>Su Qin</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Kosior-Jarecka</surname><given-names>Ewa</given-names></name><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Lukasik</surname><given-names>Urszula</given-names></name><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Krumbiegel</surname><given-names>Mandy</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Vithana</surname><given-names>Eranga N</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Wong</surname><given-names>Tien Yin</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Yutao</given-names></name><xref ref-type="aff" rid="A52">52</xref><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Ashley Koch</surname><given-names>Allison E.</given-names></name><xref ref-type="aff" rid="A52">52</xref></contrib><contrib contrib-type="author"><name><surname>Challa</surname><given-names>Pratap</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Rautenbach</surname><given-names>Robyn M</given-names></name><xref ref-type="aff" rid="A54">54</xref></contrib><contrib contrib-type="author"><name><surname>Mackey</surname><given-names>David A.</given-names></name><xref ref-type="aff" rid="A55">55</xref></contrib><contrib contrib-type="author"><name><surname>Hewitt</surname><given-names>Alex W</given-names></name><xref ref-type="aff" rid="A13">13</xref><xref ref-type="aff" rid="A56">56</xref></contrib><contrib contrib-type="author"><name><surname>Mitchell</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="A57">57</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Jie Jin</given-names></name><xref ref-type="aff" rid="A57">57</xref></contrib><contrib contrib-type="author"><name><surname>Ziskind</surname><given-names>Ari</given-names></name><xref ref-type="aff" rid="A54">54</xref></contrib><contrib contrib-type="author"><name><surname>Carmichael</surname><given-names>Trevor</given-names></name><xref ref-type="aff" rid="A25">25</xref></contrib><contrib contrib-type="author"><name><surname>Ramakrishnan</surname><given-names>Rangappa</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Narendran</surname><given-names>Kalpana</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Venkatesh</surname><given-names>Rangaraj</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Vijayan</surname><given-names>Saravanan</given-names></name><xref ref-type="aff" rid="A58">58</xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Peiquan</given-names></name><xref ref-type="aff" rid="A59">59</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Xueyi</given-names></name><xref ref-type="aff" rid="A60">60</xref></contrib><contrib contrib-type="author"><name><surname>Guadarrama-Vallejo</surname><given-names>Dalia</given-names></name><xref ref-type="aff" rid="A17">17</xref><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Cheng</surname><given-names>Ching Yu</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Perera</surname><given-names>Shamira A</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Husain</surname><given-names>Rahat</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Ho</surname><given-names>Su-Ling</given-names></name><xref ref-type="aff" rid="A61">61</xref></contrib><contrib contrib-type="author"><name><surname>Welge-Luessen</surname><given-names>Ulrich-Christoph</given-names></name><xref ref-type="aff" rid="A62">62</xref></contrib><contrib contrib-type="author"><name><surname>Mardin</surname><given-names>Christian</given-names></name><xref ref-type="aff" rid="A62">62</xref></contrib><contrib contrib-type="author"><name><surname>Schloetzer-Schrehardt</surname><given-names>Ursula</given-names></name><xref ref-type="aff" rid="A62">62</xref></contrib><contrib contrib-type="author"><name><surname>Hillmer</surname><given-names>Axel M.</given-names></name><xref ref-type="aff" rid="A63">63</xref></contrib><contrib contrib-type="author"><name><surname>Herms</surname><given-names>Stefan</given-names></name><xref ref-type="aff" rid="A64">64</xref><xref ref-type="aff" rid="A65">65</xref><xref ref-type="aff" rid="A66">66</xref><xref ref-type="aff" rid="A67">67</xref></contrib><contrib contrib-type="author"><name><surname>Moebus</surname><given-names>Susanne</given-names></name><xref ref-type="aff" rid="A68">68</xref></contrib><contrib contrib-type="author"><name><surname>Nöthen</surname><given-names>Markus M.</given-names></name><xref ref-type="aff" rid="A64">64</xref><xref ref-type="aff" rid="A65">65</xref></contrib><contrib contrib-type="author"><name><surname>Weisschuh</surname><given-names>Nicole</given-names></name><xref ref-type="aff" rid="A69">69</xref></contrib><contrib 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contrib-type="author"><collab>Wellcome Trust Case Control Consortium</collab><xref ref-type="aff" rid="A2">2</xref><xref rid="FN4" ref-type="author-notes">73</xref></contrib><contrib contrib-type="author"><name><surname>Crowston</surname><given-names>Jonathan G</given-names></name><xref ref-type="aff" rid="A56">56</xref><xref ref-type="aff" rid="A73">74</xref></contrib><contrib contrib-type="author"><name><surname>Coote</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="A56">56</xref><xref ref-type="aff" rid="A73">74</xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Bowen</given-names></name><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Sang</surname><given-names>Jinghong</given-names></name><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Nihong</given-names></name><xref ref-type="aff" 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contrib-type="author"><name><surname>Coleman</surname><given-names>Anne L</given-names></name><xref ref-type="aff" rid="A77">78</xref></contrib><contrib contrib-type="author"><name><surname>Wilson</surname><given-names>M Roy</given-names></name><xref ref-type="aff" rid="A78">79</xref></contrib><contrib contrib-type="author"><name><surname>Rhee</surname><given-names>Douglas J</given-names></name><xref ref-type="aff" rid="A79">80</xref></contrib><contrib contrib-type="author"><name><surname>Kang</surname><given-names>Jae Hee</given-names></name><xref ref-type="aff" rid="A80">81</xref></contrib><contrib contrib-type="author"><name><surname>May-Bolchakova</surname><given-names>Inna</given-names></name><xref ref-type="aff" rid="A81">82</xref></contrib><contrib contrib-type="author"><name><surname>Heegaard</surname><given-names>Steffen</given-names></name><xref ref-type="aff" rid="A82">83</xref><xref ref-type="aff" rid="A83">84</xref></contrib><contrib contrib-type="author"><name><surname>Mori</surname><given-names>Kazuhiko</given-names></name><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Alward</surname><given-names>Wallace L.M.</given-names></name><xref ref-type="aff" rid="A84">85</xref><xref ref-type="aff" rid="A85">86</xref></contrib><contrib contrib-type="author"><name><surname>Jonas</surname><given-names>Jost B</given-names></name><xref ref-type="aff" rid="A86">87</xref></contrib><contrib contrib-type="author"><name><surname>Xu</surname><given-names>Liang</given-names></name><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Liebmann</surname><given-names>Jeffrey M</given-names></name><xref ref-type="aff" rid="A87">88</xref></contrib><contrib contrib-type="author"><name><surname>Chowbay</surname><given-names>Balram</given-names></name><xref ref-type="aff" rid="A88">89</xref></contrib><contrib contrib-type="author"><name><surname>Schaeffeler</surname><given-names>Elke</given-names></name><xref ref-type="aff" rid="A89">90</xref></contrib><contrib contrib-type="author"><name><surname>Schwab</surname><given-names>Matthias</given-names></name><xref ref-type="aff" rid="A89">90</xref><xref ref-type="aff" rid="A90">91</xref><xref ref-type="aff" rid="A91">92</xref></contrib><contrib contrib-type="author"><name><surname>Lerner</surname><given-names>Fabian</given-names></name><xref ref-type="aff" rid="A92">93</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Ningli</given-names></name><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Zhenglin</given-names></name><xref ref-type="aff" rid="A28">28</xref><xref ref-type="aff" rid="A29">29</xref><xref ref-type="aff" rid="A30">30</xref></contrib><contrib contrib-type="author"><name><surname>Frezzotti</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="A93">94</xref></contrib><contrib contrib-type="author"><name><surname>Kinoshita</surname><given-names>Shigeru</given-names></name><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Fingert</surname><given-names>John H.</given-names></name><xref ref-type="aff" rid="A84">85</xref><xref ref-type="aff" rid="A85">86</xref></contrib><contrib contrib-type="author"><name><surname>Inatani</surname><given-names>Masaru</given-names></name><xref ref-type="aff" rid="A94">95</xref></contrib><contrib contrib-type="author"><name><surname>Tashiro</surname><given-names>Kei</given-names></name><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>Reis</surname><given-names>André</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Edward</surname><given-names>Deepak P.</given-names></name><xref ref-type="aff" rid="A22">22</xref><xref ref-type="aff" rid="A95">96</xref></contrib><contrib contrib-type="author"><name><surname>Pasquale</surname><given-names>Louis R.</given-names></name><xref ref-type="aff" rid="A79">80</xref><xref ref-type="aff" rid="A80">81</xref></contrib><contrib contrib-type="author"><name><surname>Kubota</surname><given-names>Toshiaki</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Wiggs</surname><given-names>Janey L.</given-names></name><xref ref-type="aff" rid="A79">80</xref><xref rid="FN3" ref-type="author-notes">**</xref></contrib><contrib contrib-type="author"><name><surname>Pasutto</surname><given-names>Francesca</given-names></name><xref ref-type="aff" rid="A10">10</xref><xref rid="FN3" ref-type="author-notes">**</xref></contrib><contrib contrib-type="author"><name><surname>Topouzis</surname><given-names>Fotis</given-names></name><xref ref-type="aff" rid="A75">76</xref><xref rid="FN3" ref-type="author-notes">**</xref></contrib><contrib contrib-type="author"><name><surname>Dubina</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="A14">14</xref><xref ref-type="aff" rid="A74">75</xref><xref rid="FN3" ref-type="author-notes">**</xref></contrib><contrib contrib-type="author"><name><surname>Craig</surname><given-names>Jamie E.</given-names></name><xref ref-type="aff" rid="A12">12</xref><xref rid="FN3" ref-type="author-notes">**</xref></contrib><contrib contrib-type="author"><name><surname>Yoshimura</surname><given-names>Nagahisa</given-names></name><xref ref-type="aff" rid="A49">49</xref><xref rid="FN3" ref-type="author-notes">**</xref></contrib><contrib contrib-type="author"><name><surname>Sundaresan</surname><given-names>Periasamy</given-names></name><xref ref-type="aff" rid="A58">58</xref><xref rid="FN3" ref-type="author-notes">**</xref></contrib><contrib contrib-type="author"><name><surname>John</surname><given-names>Simon W.M.</given-names></name><xref ref-type="aff" rid="A11">11</xref><xref rid="FN3" ref-type="author-notes">**</xref></contrib><contrib contrib-type="author"><name><surname>Ritch</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="A96">97</xref><xref rid="FN3" ref-type="author-notes">**</xref></contrib><contrib contrib-type="author"><name><surname>Hauser</surname><given-names>Michael A</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A52">52</xref><xref rid="FN3" ref-type="author-notes">**</xref></contrib><contrib contrib-type="author"><name><surname>Khor</surname><given-names>Chiea-Chuen</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A7">7</xref><xref rid="FN3" ref-type="author-notes">**</xref></contrib></contrib-group><aff id="A1"><label>1</label>Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</aff><aff id="A2"><label>2</label>Singapore National Eye Center, 11 Third Hospital Avenue, Singapore 168751</aff><aff id="A3"><label>3</label>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</aff><aff id="A4"><label>4</label>Ozaki Eye Hospital, 1-15, Kamezaki, Hyuga, Miyazaki 883-0066 Japan</aff><aff id="A5"><label>5</label>Mizoguchi Eye Hospital, 6-13 Tawara-machi, Sasebo, Nagasaki, Japan 857-0016</aff><aff id="A6"><label>6</label>Department of Ophthalmology, Duke University Eye Center, Durham, NC</aff><aff id="A7"><label>7</label>Division of Human Genetics, Genome Institute of Singapore</aff><aff id="A8"><label>8</label>Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai, India</aff><aff id="A9"><label>9</label>Department of Ophthalmology, Oita University Faculty of Medicine</aff><aff id="A10"><label>10</label>Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</aff><aff id="A11"><label>11</label>The Howard Hughes Medical Institute, the Jackson Laboratory 600 Main Street, Bar Harbor, ME 04609</aff><aff id="A12"><label>12</label>Department of Ophthalmology, Flinders University, Adelaide, SA, Australia</aff><aff id="A13"><label>13</label>Menzies Institute for Medical Research, University of Tasmania</aff><aff id="A14"><label>14</label>Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, 6/8 L’va Tolstogo Street, 197022 St. Petersburg, Russia</aff><aff id="A15"><label>15</label>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia</aff><aff id="A16"><label>16</label>Department of Ophthalmology, College of Medicine, University of Florida, Jacksonville, FL, USA</aff><aff id="A17"><label>17</label>Genetics Department, Institute of Ophthalmology “Conde de Valenciana”, Mexico</aff><aff id="A18"><label>18</label>Biochemistry Department, Faculty of Medicine, UNAM, Mexico City, Mexico</aff><aff id="A19"><label>19</label>Department of Ophthalmology, Eskisehir Osmangazi University, Meselik, Eskisehir, Turkey</aff><aff id="A20"><label>20</label>Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland, Chmielna 1, 20-079 Lublin, Poland</aff><aff id="A21"><label>21</label>Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</aff><aff id="A22"><label>22</label>King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia</aff><aff id="A23"><label>23</label>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China</aff><aff id="A24"><label>24</label>Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China</aff><aff id="A25"><label>25</label>Division of Ophthalmology, Department of Neurosciences, University of the Witwatersrand, Johannesburg, South Africa</aff><aff id="A26"><label>26</label>Department of Ophthalmology, Monfalcone Hospital, Gorizia, Italy</aff><aff id="A27"><label>27</label>Organización Médica de Investigación, Uruguay 725 – PB, Buenos Aires (C1015ABO) Argentina</aff><aff id="A28"><label>28</label>Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People’s Hospital, Chengdu, China</aff><aff id="A29"><label>29</label>School of Medicine, University of Electronic Science and Technology of China, Chengdu, China</aff><aff id="A30"><label>30</label>Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, China</aff><aff id="A31"><label>31</label>Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan</aff><aff id="A32"><label>32</label>Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan</aff><aff id="A33"><label>33</label>Glaucoma services, Narayana Nethralaya Eye Hospital, 121/C, Chord Road, Rajajinagar, 1st R Block, Bangalore 560 010, India</aff><aff id="A34"><label>34</label>Hayashi Eye Hospital, 4-23-35, Hakataekimae, Hakata-ku, Fukuoka, Japan</aff><aff id="A35"><label>35</label>Shinjo Eye Clinic, 889-1,Mego, Simokitakatamachi, Miyazaki-shi, Miyazaki 880-0035,Japan</aff><aff id="A36"><label>36</label>Ideta Eye Hospital, Kumamoto, Japan</aff><aff id="A37"><label>37</label>Miyata Eye Hospital, 6-3, Kurahara, Miyakonojo, Miyazaki 885-0051 Japan</aff><aff id="A38"><label>38</label>Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan</aff><aff id="A39"><label>39</label>Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan</aff><aff id="A40"><label>40</label>Sensho-kai Eye Institute, Minamiyama 50-1, Iseda, Uji, Kyoto 611-0043, Japan</aff><aff id="A41"><label>41</label>Inouye Eye Hospital, Tokyo, Japan</aff><aff id="A42"><label>42</label>Department of Medicine and Engineering Combined Research Institute, Asahikawa Medical University, Asahikawa, Japan</aff><aff id="A43"><label>43</label>Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan</aff><aff id="A44"><label>44</label>Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima, Japan</aff><aff id="A45"><label>45</label>Yotsuya Shirato Eye Clinic, Tokyo, Japan</aff><aff id="A46"><label>46</label>Ohashi eye center, Kita1-1 Hondori6 Shiroishi-ku Sapporo 003-0027 Japan</aff><aff id="A47"><label>47</label>Tane Memorial Eye Hospital, Osaka</aff><aff id="A48"><label>48</label>Center for Genomic Medicine/Inserm U.852, Kyoto University Graduate School of Medicine, Kyoto, Japan</aff><aff id="A49"><label>49</label>Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan</aff><aff id="A50"><label>50</label>University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Qld, Australia</aff><aff id="A51"><label>51</label>Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Canada</aff><aff id="A52"><label>52</label>Department of Medicine, Duke University Medical Center, Durham, North Carolina</aff><aff id="A53"><label>53</label>Department of Cellular Biology and Anatomy, Georgia Regents University, Augusta, Georgia</aff><aff id="A54"><label>54</label>Division of Ophthalmology, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town, South Africa</aff><aff id="A55"><label>55</label>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Australia</aff><aff id="A56"><label>56</label>Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia</aff><aff id="A57"><label>57</label>Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, NSW Australia</aff><aff id="A58"><label>58</label>Department of Genetics, Aravind Medical Research Foundation, Madurai, India</aff><aff id="A59"><label>59</label>Department of Ophthalmology, Xin Hua Hospital affiliated to Shanghai Jiao Tong University, School of Medicine, No. 1665, Kongjiang Road, Shanghai 200092, China</aff><aff id="A60"><label>60</label>Department of Ophthalmology, the First Affiliated Hospital of Xinjiang Medical University, Urumchi 830054, Xinjiang Uygur Autonomous Region, China</aff><aff id="A61"><label>61</label>National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore</aff><aff id="A62"><label>62</label>Department of Ophthalmology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</aff><aff id="A63"><label>63</label>Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore</aff><aff id="A64"><label>64</label>Institute of Human Genetics, University of Bonn, Bonn, Germany</aff><aff id="A65"><label>65</label>Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</aff><aff id="A66"><label>66</label>Division of Medical Genetics, University Hospital, Basel, Switzerland</aff><aff id="A67"><label>67</label>Human Genetics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland</aff><aff id="A68"><label>68</label>Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany</aff><aff id="A69"><label>69</label>University Eye Hospital, Wuerzburg, Germany</aff><aff id="A70"><label>70</label>Genes, Repair and Regeneration in Ophthalmic Workstation Research Lab, Narayana Nethralaya Foundation, Bangalore, India</aff><aff id="A71"><label>71</label>Saw Swee Hock School of Public Health, National University of Singapore, Singapore</aff><aff id="A72"><label>72</label>Centro Oftalmologico Lischinsky, Junin 692, Tucuman (4000) – Argentina</aff><aff id="A73"><label>74</label>Department of Ophthalmology, University of Melbourne</aff><aff id="A74"><label>75</label>St. Petersburg Academic University, 8/3 Klopina Street, 194021 St. Petersburg, Russia</aff><aff id="A75"><label>76</label>Department of Ophthalmology, Faculty of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece</aff><aff id="A76"><label>77</label>Department of Biology and Genetics, Faculty of Medicine, Aristotle University of Thessaloniki, Greece</aff><aff id="A77"><label>78</label>Center for Community Outreach and Policy, Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 United States</aff><aff id="A78"><label>79</label>Wayne State University, Detroit, 48202, United States</aff><aff id="A79"><label>80</label>Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America</aff><aff id="A80"><label>81</label>Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America</aff><aff id="A81"><label>82</label>Ophthalmology Department, Military Hospital Begin, Paris, France</aff><aff id="A82"><label>83</label>Eye Pathology Institute, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark</aff><aff id="A83"><label>84</label>Department of Ophthalmology, Glostrup University Hospital, Glostrup, Denmark</aff><aff id="A84"><label>85</label>Stephen A. Wynn Institute for Vision Research, University of Iowa, USA</aff><aff id="A85"><label>86</label>Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City</aff><aff id="A86"><label>87</label>Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Germany</aff><aff id="A87"><label>88</label>New York University School of Medicine; Manhattan Eye, Ear and Throat Hospital, New York</aff><aff id="A88"><label>89</label>Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre of Singapore</aff><aff id="A89"><label>90</label>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, and University Tuebingen, Germany</aff><aff id="A90"><label>91</label>Department of Clinical Pharmacology, University Hospital, Tuebingen, Germany</aff><aff id="A91"><label>92</label>German Cancer Consortium (DKTK), German Cancer Research Center, Heidelberg, Germany</aff><aff id="A92"><label>93</label>Fundacion para el Estudio del Glaucoma, Marcelo T de Alvear 2010 - 2A Buenos Aires (C1122AAF) Argentina</aff><aff id="A93"><label>94</label>Department of Surgery, Section of Ophthalmology, University of Siena, Siena, Italy</aff><aff id="A94"><label>95</label>Department of Ophthalmology, Faculty of Medical Science, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Eiheiji, Yoshida, Fukui, 910-1193, Japan</aff><aff id="A95"><label>96</label>Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America</aff><aff id="A96"><label>97</label>Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, United States of America</aff><author-notes><corresp id="FN1">Correspondence should be addressed to T.A. <email>aung_tin@yahoo.co.uk</email>, or to C.C.K <email>khorcc@gis.a-star.edu.sg</email></corresp><fn id="FN2" fn-type="equal"><label>*</label><p>These authors contributed equally to this work</p></fn><fn id="FN3"><label>**</label><p>These authors jointly supervised this work</p></fn><fn id="FN4"><label>73</label><p>A full list of members and affiliations appears in the <xref rid="SD1" ref-type="supplementary-material">Supplementary Note</xref></p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>3</day><month>4</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>23</day><month>2</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>14</day><month>10</month><year>2015</year></pub-date><volume>47</volume><issue>4</issue><fpage>387</fpage><lpage>392</lpage><pmc-comment>elocation-id from pubmed: 10.1038/ng.3226</pmc-comment>
<abstract><p id="P1">Exfoliation syndrome (XFS) is the commonest recognizable cause of open angle glaucoma world-wide. To better understand the etiology of XFS, we conducted a genome-wide association study (GWAS) on 1,484 patients and 1,188 controls from Japan, and followed up the most significant findings on a further 6,901 patients and 20,727 controls from 17 countries across 6 continents. We discovered a significant association between a new locus (<italic>CACNA1A</italic> rs4926244) and increased susceptibility to XFS (Odds ratio [OR] = 1.16, <italic>P</italic> = 3.36 × 10<sup>−11</sup>). Although overwhelming association at the <italic>LOXL1</italic> locus was confirmed, the key SNP marker (<italic>LOXL1</italic> rs4886776) demonstrated allelic reversal depending on ethnic grouping (In Japanese: OR<sub>A-allele</sub>= 9.87, <italic>P</italic> = 2.13 × 10<sup>−217</sup>; In non-Japanese: OR<sub>A-allele</sub>= 0.49, <italic>P</italic> = 2.35 × 10<sup>−31</sup>). Our findings represent the first genetic locus outside of <italic>LOXL1</italic> which surpasses genome-wide significance for XFS, and provides insight into the biology and pathogenesis of the disease.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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