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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genome-wide association analysis identifies six new loci associated with forced vital capacity</title><author><name sortKey="Loth, Daan W" sort="Loth, Daan W" uniqKey="Loth D" first="Daan W." last="Loth">Daan W. Loth</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Netherlands Health Care Inspectorate, The Hague, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Artigas, Maria Soler" sort="Artigas, Maria Soler" uniqKey="Artigas M" first="María Soler" last="Artigas">María Soler Artigas</name><affiliation><nlm:aff id="A3">Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A4">National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK.</nlm:aff></affiliation></author><author><name sortKey="Gharib, Sina A" sort="Gharib, Sina A" uniqKey="Gharib S" first="Sina A." last="Gharib">Sina A. Gharib</name><affiliation><nlm:aff id="A5">Computational Medicine Core, Center for Lung Biology, University of Washington, Seattle, WA, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Department of Medicine, University of Washington, Seattle, WA, USA.</nlm:aff></affiliation></author><author><name sortKey="Wain, Louise V" sort="Wain, Louise V" uniqKey="Wain L" first="Louise V." last="Wain">Louise V. Wain</name><affiliation><nlm:aff id="A3">Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A4">National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK.</nlm:aff></affiliation></author><author><name sortKey="Franceschini, Nora" sort="Franceschini, Nora" uniqKey="Franceschini N" first="Nora" last="Franceschini">Nora Franceschini</name><affiliation><nlm:aff id="A7">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Carolina Center for Genome Sciences University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:aff></affiliation></author><author><name sortKey="Koch, Beate" sort="Koch, Beate" uniqKey="Koch B" first="Beate" last="Koch">Beate Koch</name><affiliation><nlm:aff id="A9">Department of Internal Medicine B - Pneumology, Cardiology, Intensive Care and Infectious Diseases, University Hospital Greifswald, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Pottinger, Tess" sort="Pottinger, Tess" uniqKey="Pottinger T" first="Tess" last="Pottinger">Tess Pottinger</name><affiliation><nlm:aff id="A10">Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name><affiliation><nlm:aff id="A11">Iceland Heart Association, Kopavogur, Iceland.</nlm:aff></affiliation><affiliation><nlm:aff id="A12">University of Iceland, Reykjavik, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Duan, Qing" sort="Duan, Qing" uniqKey="Duan Q" first="Qing" last="Duan">Qing Duan</name><affiliation><nlm:aff id="A13">Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.</nlm:aff></affiliation></author><author><name sortKey="Oldmeadow, Chris" sort="Oldmeadow, Chris" uniqKey="Oldmeadow C" first="Chris" last="Oldmeadow">Chris Oldmeadow</name><affiliation><nlm:aff id="A14">Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff></affiliation></author><author><name sortKey="Lee, Mi Kyeong" sort="Lee, Mi Kyeong" uniqKey="Lee M" first="Mi Kyeong" last="Lee">Mi Kyeong Lee</name><affiliation><nlm:aff id="A16">Institute of Health and Environment, Seoul National University, Seoul, South Korea.</nlm:aff></affiliation></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P." last="Strachan">David P. Strachan</name><affiliation><nlm:aff id="A17">Division of Population Health Sciences and Education, St George's, University of London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="James, Alan L" sort="James, Alan L" uniqKey="James A" first="Alan L." last="James">Alan L. James</name><affiliation><nlm:aff id="A18">Department of Pulmonary Physiology and Sleep Medicine/West Australian Sleep Disorders Research Institute, Nedlands, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A19">School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Busselton Population Medical Research Institute, Busselton, Australia.</nlm:aff></affiliation></author><author><name sortKey="Huffman, Jennifer E" sort="Huffman, Jennifer E" uniqKey="Huffman J" first="Jennifer E." last="Huffman">Jennifer E. Huffman</name><affiliation><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Ramasamy, Adaikalavan" sort="Ramasamy, Adaikalavan" uniqKey="Ramasamy A" first="Adaikalavan" last="Ramasamy">Adaikalavan Ramasamy</name><affiliation><nlm:aff id="A22">Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A24">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.</nlm:aff></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation><nlm:aff id="A25">Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A26">The National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Wang, Xin Qun" sort="Wang, Xin Qun" uniqKey="Wang X" first="Xin-Qun" last="Wang">Xin-Qun Wang</name><affiliation><nlm:aff id="A28">Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.</nlm:aff></affiliation></author><author><name sortKey="Trochet, Holly" sort="Trochet, Holly" uniqKey="Trochet H" first="Holly" last="Trochet">Holly Trochet</name><affiliation><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:aff id="A29">Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland.</nlm:aff></affiliation></author><author><name sortKey="Flexeder, Claudia" sort="Flexeder, Claudia" uniqKey="Flexeder C" first="Claudia" last="Flexeder">Claudia Flexeder</name><affiliation><nlm:aff id="A30">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Albrecht, Eva" sort="Albrecht, Eva" uniqKey="Albrecht E" first="Eva" last="Albrecht">Eva Albrecht</name><affiliation><nlm:aff id="A31">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M." last="Lopez">Lorna M. Lopez</name><affiliation><nlm:aff id="A32">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Department of Psychology, The University of Edinburgh, Edinburgh, UK.</nlm:aff></affiliation></author><author><name sortKey="De Jong, Kim" sort="De Jong, Kim" uniqKey="De Jong K" first="Kim" last="De Jong">Kim De Jong</name><affiliation><nlm:aff id="A34">University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A35">GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Thyagarajan, Bharat" sort="Thyagarajan, Bharat" uniqKey="Thyagarajan B" first="Bharat" last="Thyagarajan">Bharat Thyagarajan</name><affiliation><nlm:aff id="A36">Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.</nlm:aff></affiliation></author><author><name sortKey="Alves, Alexessander Couto" sort="Alves, Alexessander Couto" uniqKey="Alves A" first="Alexessander Couto" last="Alves">Alexessander Couto Alves</name><affiliation><nlm:aff id="A23">Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Enroth, Stefan" sort="Enroth, Stefan" uniqKey="Enroth S" first="Stefan" last="Enroth">Stefan Enroth</name><affiliation><nlm:aff id="A37">Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Omenaas, Ernst" sort="Omenaas, Ernst" uniqKey="Omenaas E" first="Ernst" last="Omenaas">Ernst Omenaas</name><affiliation><nlm:aff id="A39">Haukeland University Hospital, Bergen, Norway.</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Department Clinical Sciences, University of Bergen, Bergen, Norway.</nlm:aff></affiliation></author><author><name sortKey="Joshi, Peter K" sort="Joshi, Peter K" uniqKey="Joshi P" first="Peter K." last="Joshi">Peter K. Joshi</name><affiliation><nlm:aff id="A41">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Fall, Tove" sort="Fall, Tove" uniqKey="Fall T" first="Tove" last="Fall">Tove Fall</name><affiliation><nlm:aff id="A38">Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Vi Uela, Ana" sort="Vi Uela, Ana" uniqKey="Vi Uela A" first="Ana" last="Vi Uela">Ana Vi Uela</name><affiliation><nlm:aff id="A43">Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><affiliation><nlm:aff id="A44">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</nlm:aff></affiliation></author><author><name sortKey="Loehr, Laura R" sort="Loehr, Laura R" uniqKey="Loehr L" first="Laura R." last="Loehr">Laura R. Loehr</name><affiliation><nlm:aff id="A7">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Carolina Center for Genome Sciences University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:aff></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation><nlm:aff id="A45">Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A46">Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:aff></affiliation></author><author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name><affiliation><nlm:aff id="A47">Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.</nlm:aff></affiliation></author><author><name sortKey="Wilk, Jemma B" sort="Wilk, Jemma B" uniqKey="Wilk J" first="Jemma B." last="Wilk">Jemma B. Wilk</name><affiliation><nlm:aff id="A48">Precision Medicine, Pfizer Global Research and Development, Cambridge, MA, USA.</nlm:aff></affiliation></author><author><name sortKey="Tang, Wenbo" sort="Tang, Wenbo" uniqKey="Tang W" first="Wenbo" last="Tang">Wenbo Tang</name><affiliation><nlm:aff id="A49">Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.</nlm:aff></affiliation></author><author><name sortKey="Manichaikul, Ani" sort="Manichaikul, Ani" uniqKey="Manichaikul A" first="Ani" last="Manichaikul">Ani Manichaikul</name><affiliation><nlm:aff id="A50">Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A51">Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA</nlm:aff></affiliation></author><author><name sortKey="Lahousse, Lies" sort="Lahousse, Lies" uniqKey="Lahousse L" first="Lies" last="Lahousse">Lies Lahousse</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="A44">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</nlm:aff></affiliation></author><author><name sortKey="North, Kari E" sort="North, Kari E" uniqKey="North K" first="Kari E." last="North">Kari E. North</name><affiliation><nlm:aff id="A7">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:aff></affiliation></author><author><name sortKey="Rudnicka, Alicja R" sort="Rudnicka, Alicja R" uniqKey="Rudnicka A" first="Alicja R." last="Rudnicka">Alicja R. Rudnicka</name><affiliation><nlm:aff id="A17">Division of Population Health Sciences and Education, St George's, University of London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Hui, Jennie" sort="Hui, Jennie" uniqKey="Hui J" first="Jennie" last="Hui">Jennie Hui</name><affiliation><nlm:aff id="A53">PathWest Laboratory Medicine WA, Nedlands, Australia.</nlm:aff></affiliation></author><author><name sortKey="Gu, Xiangjun" sort="Gu, Xiangjun" uniqKey="Gu X" first="Xiangjun" last="Gu">Xiangjun Gu</name><affiliation><nlm:aff id="A45">Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A46">Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:aff></affiliation></author><author><name sortKey="Lumley, Thomas" sort="Lumley, Thomas" uniqKey="Lumley T" first="Thomas" last="Lumley">Thomas Lumley</name><affiliation><nlm:aff id="A54">Department of Statistics, University of Auckland, Auckland, New Zealand.</nlm:aff></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name><affiliation><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Hastie, Nicholas D" sort="Hastie, Nicholas D" uniqKey="Hastie N" first="Nicholas D." last="Hastie">Nicholas D. Hastie</name><affiliation><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Campbell, Susan" sort="Campbell, Susan" uniqKey="Campbell S" first="Susan" last="Campbell">Susan Campbell</name><affiliation><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Kumar, Rajesh" sort="Kumar, Rajesh" uniqKey="Kumar R" first="Rajesh" last="Kumar">Rajesh Kumar</name><affiliation><nlm:aff id="A55">Northwestern University Feinberg School of Medicine, Chicago, IL, USA.</nlm:aff></affiliation></author><author><name sortKey="Pin, Isabelle" sort="Pin, Isabelle" uniqKey="Pin I" first="Isabelle" last="Pin">Isabelle Pin</name><affiliation><nlm:aff id="A56">Centre Hospitallier Universitaire de Grenoble, Grenoble, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A57">INSERM U823, Institut Albert Bonniot, Grenoble, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A58">Université Joseph Fourier, Grenoble, France.</nlm:aff></affiliation></author><author><name sortKey="Scott, Robert A" sort="Scott, Robert A" uniqKey="Scott R" first="Robert A." last="Scott">Robert A. Scott</name><affiliation><nlm:aff id="A24">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.</nlm:aff></affiliation></author><author><name sortKey="Pietil Inen, Kirsi H" sort="Pietil Inen, Kirsi H" uniqKey="Pietil Inen K" first="Kirsi H." last="Pietil Inen">Kirsi H. Pietil Inen</name><affiliation><nlm:aff id="A27">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A60">Department of Medicine, Division of Internal Medicine, Helsinki University Central Hospital, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Surakka, Ida" sort="Surakka, Ida" uniqKey="Surakka I" first="Ida" last="Surakka">Ida Surakka</name><affiliation><nlm:aff id="A27">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Public Health Genomics Unit, Department of Chronic Disease Prevention, The National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation><nlm:aff id="A62">Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.</nlm:aff></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name><affiliation><nlm:aff id="A14">Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff></affiliation></author><author><name sortKey="Schulz, Holger" sort="Schulz, Holger" uniqKey="Schulz H" first="Holger" last="Schulz">Holger Schulz</name><affiliation><nlm:aff id="A30">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name><affiliation><nlm:aff id="A30">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Davies, Gail" sort="Davies, Gail" uniqKey="Davies G" first="Gail" last="Davies">Gail Davies</name><affiliation><nlm:aff id="A32">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Department of Psychology, The University of Edinburgh, Edinburgh, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A63">Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, Edinburgh, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A64">MRC Institute of Genetics and Molecular Medicine, Edinburgh, UK.</nlm:aff></affiliation></author><author><name sortKey="Vonk, Judith M" sort="Vonk, Judith M" uniqKey="Vonk J" first="Judith M." last="Vonk">Judith M. Vonk</name><affiliation><nlm:aff id="A34">University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A35">GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Wojczynski, Mary" sort="Wojczynski, Mary" uniqKey="Wojczynski M" first="Mary" last="Wojczynski">Mary Wojczynski</name><affiliation><nlm:aff id="A65">Department of Statistical Genomics, Washington University, St. Louis, MO, USA.</nlm:aff></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation><nlm:aff id="A66">National Institute for Health and Welfare, Oulu, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation><nlm:aff id="A37">Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name><affiliation><nlm:aff id="A41">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation><nlm:aff id="A38">Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation><affiliation><nlm:aff id="A69">Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation><affiliation><nlm:aff id="A70">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.</nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="A71">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation><nlm:aff id="A73">Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Hysi, Pirro G" sort="Hysi, Pirro G" uniqKey="Hysi P" first="Pirro G." last="Hysi">Pirro G. Hysi</name><affiliation><nlm:aff id="A43">Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation><nlm:aff id="A11">Iceland Heart Association, Kopavogur, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Morrison, Alanna C" sort="Morrison, Alanna C" uniqKey="Morrison A" first="Alanna C." last="Morrison">Alanna C. Morrison</name><affiliation><nlm:aff id="A74">School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:aff></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name><affiliation><nlm:aff id="A75">Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.</nlm:aff></affiliation></author><author><name sortKey="Gao, Wei" sort="Gao, Wei" uniqKey="Gao W" first="Wei" last="Gao">Wei Gao</name><affiliation><nlm:aff id="A77">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.</nlm:aff></affiliation></author><author><name sortKey="Postma, Dirkje S" sort="Postma, Dirkje S" uniqKey="Postma D" first="Dirkje S." last="Postma">Dirkje S. Postma</name><affiliation><nlm:aff id="A35">GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A78">University of Groningen, University Medical Center Groningen, Department of Pulmonology, Groningen, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="White, Wendy B" sort="White, Wendy B" uniqKey="White W" first="Wendy B." last="White">Wendy B. White</name><affiliation><nlm:aff id="A79">Tougaloo College, Jackson, MS, USA.</nlm:aff></affiliation></author><author><name sortKey="Rich, Stephen S" sort="Rich, Stephen S" uniqKey="Rich S" first="Stephen S." last="Rich">Stephen S. Rich</name><affiliation><nlm:aff id="A50">Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A51">Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name><affiliation><nlm:aff id="A11">Iceland Heart Association, Kopavogur, Iceland.</nlm:aff></affiliation><affiliation><nlm:aff id="A12">University of Iceland, Reykjavik, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Couper, David" sort="Couper, David" uniqKey="Couper D" first="David" last="Couper">David Couper</name><affiliation><nlm:aff id="A80">Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:aff></affiliation></author><author><name sortKey="Smith, Lewis J" sort="Smith, Lewis J" uniqKey="Smith L" first="Lewis J." last="Smith">Lewis J. Smith</name><affiliation><nlm:aff id="A55">Northwestern University Feinberg School of Medicine, Chicago, IL, USA.</nlm:aff></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name><affiliation><nlm:aff id="A6">Department of Medicine, University of Washington, Seattle, WA, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A47">Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A81">Department of Epidemiology, University of Washington, Seattle, WA, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A82">Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.</nlm:aff></affiliation></author><author><name sortKey="Lohman, Kurt" sort="Lohman, Kurt" uniqKey="Lohman K" first="Kurt" last="Lohman">Kurt Lohman</name><affiliation><nlm:aff id="A83">Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.</nlm:aff></affiliation></author><author><name sortKey="Burchard, Esteban G" sort="Burchard, Esteban G" uniqKey="Burchard E" first="Esteban G." last="Burchard">Esteban G. Burchard</name><affiliation><nlm:aff id="A84">Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, CA, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A85">Department of Medicine, University of California, San Francisco, CA, USA.</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G." last="Uitterlinden">André G. Uitterlinden</name><affiliation><nlm:aff id="A71">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Garcia, Melissa" sort="Garcia, Melissa" uniqKey="Garcia M" first="Melissa" last="Garcia">Melissa Garcia</name><affiliation><nlm:aff id="A44">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</nlm:aff></affiliation></author><author><name sortKey="Joubert, Bonnie R" sort="Joubert, Bonnie R" uniqKey="Joubert B" first="Bonnie R." last="Joubert">Bonnie R. Joubert</name><affiliation><nlm:aff id="A86">Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.</nlm:aff></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L." last="Mcardle">Wendy L. Mcardle</name><affiliation><nlm:aff id="A87">School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</nlm:aff></affiliation></author><author><name sortKey="Musk, A Bill" sort="Musk, A Bill" uniqKey="Musk A" first="A. Bill" last="Musk">A. Bill Musk</name><affiliation><nlm:aff id="A88">Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Australia.</nlm:aff></affiliation></author><author><name sortKey="Hansel, Nadia" sort="Hansel, Nadia" uniqKey="Hansel N" first="Nadia" last="Hansel">Nadia Hansel</name><affiliation><nlm:aff id="A89">Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.</nlm:aff></affiliation></author><author><name sortKey="Heckbert, Susan R" sort="Heckbert, Susan R" uniqKey="Heckbert S" first="Susan R." last="Heckbert">Susan R. Heckbert</name><affiliation><nlm:aff id="A47">Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A81">Department of Epidemiology, University of Washington, Seattle, WA, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A82">Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.</nlm:aff></affiliation></author><author><name sortKey="Zgaga, Lina" sort="Zgaga, Lina" uniqKey="Zgaga L" first="Lina" last="Zgaga">Lina Zgaga</name><affiliation><nlm:aff id="A90">Department of Public Health and Primary Care, Trinity College Dublin, Dublin, Ireland.</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Adrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Van Meurs, Joyce B J" sort="Van Meurs, Joyce B J" uniqKey="Van Meurs J" first="Joyce B. J." last="Van Meurs">Joyce B. J. Van Meurs</name><affiliation><nlm:aff id="A71">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Navarro, Pau" sort="Navarro, Pau" uniqKey="Navarro P" first="Pau" last="Navarro">Pau Navarro</name><affiliation><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="A92">Centre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Oh, Yeon Mok" sort="Oh, Yeon Mok" uniqKey="Oh Y" first="Yeon-Mok" last="Oh">Yeon-Mok Oh</name><affiliation><nlm:aff id="A93">Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.</nlm:aff></affiliation><affiliation><nlm:aff id="A94">Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.</nlm:aff></affiliation></author><author><name sortKey="Redline, Susan" sort="Redline, Susan" uniqKey="Redline S" first="Susan" last="Redline">Susan Redline</name><affiliation><nlm:aff id="A95">Department of Medicine, Brigham Women's Hospital, Boston, MA, USA.</nlm:aff></affiliation></author><author><name sortKey="Jarvis, Deborah" sort="Jarvis, Deborah" uniqKey="Jarvis D" first="Deborah" last="Jarvis">Deborah Jarvis</name><affiliation><nlm:aff id="A22">Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A96">MRC-PHE Centre for Environment & Health, Imperial College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="A24">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.</nlm:aff></affiliation></author><author><name sortKey="Rantanen, Taina" sort="Rantanen, Taina" uniqKey="Rantanen T" first="Taina" last="Rantanen">Taina Rantanen</name><affiliation><nlm:aff id="A97">Gerontology Research Centre, Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland.</nlm:aff></affiliation></author><author><name sortKey="O Onnor, George T" sort="O Onnor, George T" uniqKey="O Onnor G" first="George T." last="O Onnor">George T. O Onnor</name><affiliation><nlm:aff id="A98">Pulmonary Center, Boston University School of Medicine, Boston, MA, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A99">The NHLBI's Framingham Heart Study, Framingham, MA, USA.</nlm:aff></affiliation></author><author><name sortKey="Ripatti, Samuli" sort="Ripatti, Samuli" uniqKey="Ripatti S" first="Samuli" last="Ripatti">Samuli Ripatti</name><affiliation><nlm:aff id="A27">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Public Health Genomics Unit, Department of Chronic Disease Prevention, The National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A100">Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name><affiliation><nlm:aff id="A14">Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff></affiliation></author><author><name sortKey="Karrasch, Stefan" sort="Karrasch, Stefan" uniqKey="Karrasch S" first="Stefan" last="Karrasch">Stefan Karrasch</name><affiliation><nlm:aff id="A30">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A101">Institute for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universität, Munich, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A102">Institute of General Practice, University Hospital Klinikum rechts der Isar, Technische Universität München, Munich, Germany.</nlm:aff></affiliation></author><author><name sortKey="Grallert, Harald" sort="Grallert, Harald" uniqKey="Grallert H" first="Harald" last="Grallert">Harald Grallert</name><affiliation><nlm:aff id="A103">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Gaddis, Nathan C" sort="Gaddis, Nathan C" uniqKey="Gaddis N" first="Nathan C." last="Gaddis">Nathan C. Gaddis</name><affiliation><nlm:aff id="A104">Research Computing Division, Research Triangle Institute International, Research Triangle Park, NC, USA.</nlm:aff></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><affiliation><nlm:aff id="A32">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A105">Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.</nlm:aff></affiliation></author><author><name sortKey="Wijmenga, Cisca" sort="Wijmenga, Cisca" uniqKey="Wijmenga C" first="Cisca" last="Wijmenga">Cisca Wijmenga</name><affiliation><nlm:aff id="A106">Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Minster, Ryan L" sort="Minster, Ryan L" uniqKey="Minster R" first="Ryan L." last="Minster">Ryan L. Minster</name><affiliation><nlm:aff id="A107">Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.</nlm:aff></affiliation></author><author><name sortKey="Lederer, David J" sort="Lederer, David J" uniqKey="Lederer D" first="David J." last="Lederer">David J. Lederer</name><affiliation><nlm:aff id="A10">Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A108">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.</nlm:aff></affiliation></author><author><name sortKey="Pekkanen, Juha" sort="Pekkanen, Juha" uniqKey="Pekkanen J" first="Juha" last="Pekkanen">Juha Pekkanen</name><affiliation><nlm:aff id="A109">Department of Environmental Health, National Institute for Health and Welfare (THL), Kuopio, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A110">Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.</nlm:aff></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation><nlm:aff id="A37">Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="A41">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Morris, Andrew P" sort="Morris, Andrew P" uniqKey="Morris A" first="Andrew P." last="Morris">Andrew P. Morris</name><affiliation><nlm:aff id="A70">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.</nlm:aff></affiliation></author><author><name sortKey="Gl Ser, Sven" sort="Gl Ser, Sven" uniqKey="Gl Ser S" first="Sven" last="Gl Ser">Sven Gl Ser</name><affiliation><nlm:aff id="A9">Department of Internal Medicine B - Pneumology, Cardiology, Intensive Care and Infectious Diseases, University Hospital Greifswald, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Hammond, Christopher J" sort="Hammond, Christopher J" uniqKey="Hammond C" first="Christopher J." last="Hammond">Christopher J. Hammond</name><affiliation><nlm:aff id="A43">Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Burkart, Kristin M" sort="Burkart, Kristin M" uniqKey="Burkart K" first="Kristin M." last="Burkart">Kristin M. Burkart</name><affiliation><nlm:aff id="A10">Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff></affiliation></author><author><name sortKey="Beilby, John" sort="Beilby, John" uniqKey="Beilby J" first="John" last="Beilby">John Beilby</name><affiliation><nlm:aff id="A53">PathWest Laboratory Medicine WA, Nedlands, Australia.</nlm:aff></affiliation></author><author><name sortKey="Kritchevsky, Stephen B" sort="Kritchevsky, Stephen B" uniqKey="Kritchevsky S" first="Stephen B." last="Kritchevsky">Stephen B. Kritchevsky</name><affiliation><nlm:aff id="A111">Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, USA.</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="A11">Iceland Heart Association, Kopavogur, Iceland.</nlm:aff></affiliation><affiliation><nlm:aff id="A12">University of Iceland, Reykjavik, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Hancock, Dana B" sort="Hancock, Dana B" uniqKey="Hancock D" first="Dana B." last="Hancock">Dana B. Hancock</name><affiliation><nlm:aff id="A112">Behavioral Health Epidemiology Program, Research Triangle Institute International, Research Triangle Park, NC, USA.</nlm:aff></affiliation></author><author><name sortKey="Williams, O Dale" sort="Williams, O Dale" uniqKey="Williams O" first="O. Dale" last="Williams">O. Dale Williams</name><affiliation><nlm:aff id="A113">Florida International University, Miami, FL, USA.</nlm:aff></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation><nlm:aff id="A114">Department of Public Health, Medical School, University of Split, Split, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Zemunik, Tatijana" sort="Zemunik, Tatijana" uniqKey="Zemunik T" first="Tatijana" last="Zemunik">Tatijana Zemunik</name><affiliation><nlm:aff id="A115">Department of Medical Biology, Medical School, University of Split, Split, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name><affiliation><nlm:aff id="A114">Department of Public Health, Medical School, University of Split, Split, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Petrini, Marcy F" sort="Petrini, Marcy F" uniqKey="Petrini M" first="Marcy F." last="Petrini">Marcy F. Petrini</name><affiliation><nlm:aff id="A116">Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.</nlm:aff></affiliation></author><author><name sortKey="Wjst, Matthias" sort="Wjst, Matthias" uniqKey="Wjst M" first="Matthias" last="Wjst">Matthias Wjst</name><affiliation><nlm:aff id="A117">Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München (HMGU), München, Germany.</nlm:aff></affiliation></author><author><name sortKey="Kim, Woo Jin" sort="Kim, Woo Jin" uniqKey="Kim W" first="Woo Jin" last="Kim">Woo Jin Kim</name><affiliation><nlm:aff id="A118">Department of Internal Medicine, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea.</nlm:aff></affiliation><affiliation><nlm:aff id="A119">Environmental Health Center, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea.</nlm:aff></affiliation></author><author><name sortKey="Porteous, David J" sort="Porteous, David J" uniqKey="Porteous D" first="David J." last="Porteous">David J. Porteous</name><affiliation><nlm:aff id="A63">Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, Edinburgh, UK.</nlm:aff></affiliation></author><author><name sortKey="Scotland, Generation" sort="Scotland, Generation" uniqKey="Scotland G" first="Generation" last="Scotland">Generation Scotland</name><affiliation><nlm:aff id="A76">Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.</nlm:aff></affiliation></author><author><name sortKey="Smith, Blair H" sort="Smith, Blair H" uniqKey="Smith B" first="Blair H." last="Smith">Blair H. Smith</name><affiliation><nlm:aff id="A75">Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA.</nlm:aff></affiliation></author><author><name sortKey="Viljanen, Anne" sort="Viljanen, Anne" uniqKey="Viljanen A" first="Anne" last="Viljanen">Anne Viljanen</name><affiliation><nlm:aff id="A97">Gerontology Research Centre, Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland.</nlm:aff></affiliation></author><author><name sortKey="Heliovaara, Markku" sort="Heliovaara, Markku" uniqKey="Heliovaara M" first="Markku" last="Heliövaara">Markku Heliövaara</name><affiliation><nlm:aff id="A26">The National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Attia, John R" sort="Attia, John R" uniqKey="Attia J" first="John R." last="Attia">John R. Attia</name><affiliation><nlm:aff id="A14">Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff></affiliation></author><author><name sortKey="Sayers, Ian" sort="Sayers, Ian" uniqKey="Sayers I" first="Ian" last="Sayers">Ian Sayers</name><affiliation><nlm:aff id="A120">Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, UK.</nlm:aff></affiliation></author><author><name sortKey="Hampel, Regina" sort="Hampel, Regina" uniqKey="Hampel R" first="Regina" last="Hampel">Regina Hampel</name><affiliation><nlm:aff id="A121">Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation><nlm:aff id="A31">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><affiliation><nlm:aff id="A32">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Department of Psychology, The University of Edinburgh, Edinburgh, UK.</nlm:aff></affiliation></author><author><name sortKey="Boezen, H Marike" sort="Boezen, H Marike" uniqKey="Boezen H" first="H. Marike" last="Boezen">H. Marike Boezen</name><affiliation><nlm:aff id="A34">University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A35">GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Newman, Anne" sort="Newman, Anne" uniqKey="Newman A" first="Anne" last="Newman">Anne Newman</name><affiliation><nlm:aff id="A122">Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, PA, USA.</nlm:aff></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation><nlm:aff id="A23">Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A123">Institute of Health Sciences, University of Oulu, Oulu, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A124">Biocenter Oulu, University of Oulu, Oulu, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A125">Unit of Primary Care, Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A126">Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="A41">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation><nlm:aff id="A69">Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Stricker, Bruno H" sort="Stricker, Bruno H" uniqKey="Stricker B" first="Bruno H." last="Stricker">Bruno H. Stricker</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Netherlands Health Care Inspectorate, The Hague, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A71">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:aff id="A127">Department for Genetics and Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D." last="Spector">Timothy D. Spector</name><affiliation><nlm:aff id="A43">Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Melen, Erik" sort="Melen, Erik" uniqKey="Melen E" first="Erik" last="Melén">Erik Melén</name><affiliation><nlm:aff id="A128">Institute of Environmental Medicine, Karolinska Institutet and Sachs’ Children’s Hospital, Stockholm, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Peters, Marjolein J" sort="Peters, Marjolein J" uniqKey="Peters M" first="Marjolein J." last="Peters">Marjolein J. Peters</name><affiliation><nlm:aff id="A71">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Lange, Leslie A" sort="Lange, Leslie A" uniqKey="Lange L" first="Leslie A." last="Lange">Leslie A. Lange</name><affiliation><nlm:aff id="A13">Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.</nlm:aff></affiliation></author><author><name sortKey="Barr, R Graham" sort="Barr, R Graham" uniqKey="Barr R" first="R. Graham" last="Barr">R. Graham Barr</name><affiliation><nlm:aff id="A108">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.</nlm:aff></affiliation></author><author><name sortKey="Bracke, Ken R" sort="Bracke, Ken R" uniqKey="Bracke K" first="Ken R." last="Bracke">Ken R. Bracke</name><affiliation><nlm:aff id="A52">Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:aff></affiliation></author><author><name sortKey="Verhamme, Fien M" sort="Verhamme, Fien M" uniqKey="Verhamme F" first="Fien M." last="Verhamme">Fien M. Verhamme</name><affiliation><nlm:aff id="A52">Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:aff></affiliation></author><author><name sortKey="Sung, Joohon" sort="Sung, Joohon" uniqKey="Sung J" first="Joohon" last="Sung">Joohon Sung</name><affiliation><nlm:aff id="A16">Institute of Health and Environment, Seoul National University, Seoul, South Korea.</nlm:aff></affiliation><affiliation><nlm:aff id="A129">Complex Disease & Genetic Epidemiology Branch, Department of Epidemiology, Seoul National University School of Public Health, Seoul, South Korea.</nlm:aff></affiliation></author><author><name sortKey="Hiemstra, Pieter S" sort="Hiemstra, Pieter S" uniqKey="Hiemstra P" first="Pieter S." last="Hiemstra">Pieter S. Hiemstra</name><affiliation><nlm:aff id="A130">Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Cassano, Patricia A" sort="Cassano, Patricia A" uniqKey="Cassano P" first="Patricia A." last="Cassano">Patricia A. Cassano</name><affiliation><nlm:aff id="A49">Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A131">Department of Public Health, Division of Biostatistics and Epidemiology, Weill Cornell Medical College, New York, NY, USA.</nlm:aff></affiliation></author><author><name sortKey="Sood, Akshay" sort="Sood, Akshay" uniqKey="Sood A" first="Akshay" last="Sood">Akshay Sood</name><affiliation><nlm:aff id="A132">University of New Mexico Health Sciences Center School of Medicine, Albuquerque, NM, USA.</nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Dupuis, Josee" sort="Dupuis, Josee" uniqKey="Dupuis J" first="Josée" last="Dupuis">Josée Dupuis</name><affiliation><nlm:aff id="A77">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A99">The NHLBI's Framingham Heart Study, Framingham, MA, USA.</nlm:aff></affiliation></author><author><name sortKey="Hall, Ian P" sort="Hall, Ian P" uniqKey="Hall I" first="Ian P." last="Hall">Ian P. Hall</name><affiliation><nlm:aff id="A120">Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, UK.</nlm:aff></affiliation></author><author><name sortKey="Brusselle, Guy G" sort="Brusselle, Guy G" uniqKey="Brusselle G" first="Guy G." last="Brusselle">Guy G. Brusselle</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:aff></affiliation><affiliation><nlm:aff id="A133">Department of Respiratory Medicine, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Tobin, Martin D" sort="Tobin, Martin D" uniqKey="Tobin M" first="Martin D." last="Tobin">Martin D. Tobin</name><affiliation><nlm:aff id="A3">Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A4">National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK.</nlm:aff></affiliation></author><author><name sortKey="London, Stephanie J" sort="London, Stephanie J" uniqKey="London S" first="Stephanie J." last="London">Stephanie J. London</name><affiliation><nlm:aff id="A86">Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24929828</idno><idno type="pmc">4140093</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140093</idno><idno type="RBID">PMC:4140093</idno><idno type="doi">10.1038/ng.3011</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002146</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002146</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide association analysis identifies six new loci associated with forced vital capacity</title><author><name sortKey="Loth, Daan W" sort="Loth, Daan W" uniqKey="Loth D" first="Daan W." last="Loth">Daan W. Loth</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Netherlands Health Care Inspectorate, The Hague, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Artigas, Maria Soler" sort="Artigas, Maria Soler" uniqKey="Artigas M" first="María Soler" last="Artigas">María Soler Artigas</name><affiliation><nlm:aff id="A3">Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A4">National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK.</nlm:aff></affiliation></author><author><name sortKey="Gharib, Sina A" sort="Gharib, Sina A" uniqKey="Gharib S" first="Sina A." last="Gharib">Sina A. Gharib</name><affiliation><nlm:aff id="A5">Computational Medicine Core, Center for Lung Biology, University of Washington, Seattle, WA, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Department of Medicine, University of Washington, Seattle, WA, USA.</nlm:aff></affiliation></author><author><name sortKey="Wain, Louise V" sort="Wain, Louise V" uniqKey="Wain L" first="Louise V." last="Wain">Louise V. Wain</name><affiliation><nlm:aff id="A3">Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A4">National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK.</nlm:aff></affiliation></author><author><name sortKey="Franceschini, Nora" sort="Franceschini, Nora" uniqKey="Franceschini N" first="Nora" last="Franceschini">Nora Franceschini</name><affiliation><nlm:aff id="A7">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Carolina Center for Genome Sciences University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:aff></affiliation></author><author><name sortKey="Koch, Beate" sort="Koch, Beate" uniqKey="Koch B" first="Beate" last="Koch">Beate Koch</name><affiliation><nlm:aff id="A9">Department of Internal Medicine B - Pneumology, Cardiology, Intensive Care and Infectious Diseases, University Hospital Greifswald, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Pottinger, Tess" sort="Pottinger, Tess" uniqKey="Pottinger T" first="Tess" last="Pottinger">Tess Pottinger</name><affiliation><nlm:aff id="A10">Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name><affiliation><nlm:aff id="A11">Iceland Heart Association, Kopavogur, Iceland.</nlm:aff></affiliation><affiliation><nlm:aff id="A12">University of Iceland, Reykjavik, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Duan, Qing" sort="Duan, Qing" uniqKey="Duan Q" first="Qing" last="Duan">Qing Duan</name><affiliation><nlm:aff id="A13">Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.</nlm:aff></affiliation></author><author><name sortKey="Oldmeadow, Chris" sort="Oldmeadow, Chris" uniqKey="Oldmeadow C" first="Chris" last="Oldmeadow">Chris Oldmeadow</name><affiliation><nlm:aff id="A14">Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff></affiliation></author><author><name sortKey="Lee, Mi Kyeong" sort="Lee, Mi Kyeong" uniqKey="Lee M" first="Mi Kyeong" last="Lee">Mi Kyeong Lee</name><affiliation><nlm:aff id="A16">Institute of Health and Environment, Seoul National University, Seoul, South Korea.</nlm:aff></affiliation></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P." last="Strachan">David P. Strachan</name><affiliation><nlm:aff id="A17">Division of Population Health Sciences and Education, St George's, University of London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="James, Alan L" sort="James, Alan L" uniqKey="James A" first="Alan L." last="James">Alan L. James</name><affiliation><nlm:aff id="A18">Department of Pulmonary Physiology and Sleep Medicine/West Australian Sleep Disorders Research Institute, Nedlands, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A19">School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Busselton Population Medical Research Institute, Busselton, Australia.</nlm:aff></affiliation></author><author><name sortKey="Huffman, Jennifer E" sort="Huffman, Jennifer E" uniqKey="Huffman J" first="Jennifer E." last="Huffman">Jennifer E. Huffman</name><affiliation><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Ramasamy, Adaikalavan" sort="Ramasamy, Adaikalavan" uniqKey="Ramasamy A" first="Adaikalavan" last="Ramasamy">Adaikalavan Ramasamy</name><affiliation><nlm:aff id="A22">Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A24">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.</nlm:aff></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation><nlm:aff id="A25">Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A26">The National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Wang, Xin Qun" sort="Wang, Xin Qun" uniqKey="Wang X" first="Xin-Qun" last="Wang">Xin-Qun Wang</name><affiliation><nlm:aff id="A28">Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.</nlm:aff></affiliation></author><author><name sortKey="Trochet, Holly" sort="Trochet, Holly" uniqKey="Trochet H" first="Holly" last="Trochet">Holly Trochet</name><affiliation><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:aff id="A29">Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland.</nlm:aff></affiliation></author><author><name sortKey="Flexeder, Claudia" sort="Flexeder, Claudia" uniqKey="Flexeder C" first="Claudia" last="Flexeder">Claudia Flexeder</name><affiliation><nlm:aff id="A30">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Albrecht, Eva" sort="Albrecht, Eva" uniqKey="Albrecht E" first="Eva" last="Albrecht">Eva Albrecht</name><affiliation><nlm:aff id="A31">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M." last="Lopez">Lorna M. Lopez</name><affiliation><nlm:aff id="A32">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Department of Psychology, The University of Edinburgh, Edinburgh, UK.</nlm:aff></affiliation></author><author><name sortKey="De Jong, Kim" sort="De Jong, Kim" uniqKey="De Jong K" first="Kim" last="De Jong">Kim De Jong</name><affiliation><nlm:aff id="A34">University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A35">GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Thyagarajan, Bharat" sort="Thyagarajan, Bharat" uniqKey="Thyagarajan B" first="Bharat" last="Thyagarajan">Bharat Thyagarajan</name><affiliation><nlm:aff id="A36">Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.</nlm:aff></affiliation></author><author><name sortKey="Alves, Alexessander Couto" sort="Alves, Alexessander Couto" uniqKey="Alves A" first="Alexessander Couto" last="Alves">Alexessander Couto Alves</name><affiliation><nlm:aff id="A23">Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Enroth, Stefan" sort="Enroth, Stefan" uniqKey="Enroth S" first="Stefan" last="Enroth">Stefan Enroth</name><affiliation><nlm:aff id="A37">Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Omenaas, Ernst" sort="Omenaas, Ernst" uniqKey="Omenaas E" first="Ernst" last="Omenaas">Ernst Omenaas</name><affiliation><nlm:aff id="A39">Haukeland University Hospital, Bergen, Norway.</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Department Clinical Sciences, University of Bergen, Bergen, Norway.</nlm:aff></affiliation></author><author><name sortKey="Joshi, Peter K" sort="Joshi, Peter K" uniqKey="Joshi P" first="Peter K." last="Joshi">Peter K. Joshi</name><affiliation><nlm:aff id="A41">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Fall, Tove" sort="Fall, Tove" uniqKey="Fall T" first="Tove" last="Fall">Tove Fall</name><affiliation><nlm:aff id="A38">Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Vi Uela, Ana" sort="Vi Uela, Ana" uniqKey="Vi Uela A" first="Ana" last="Vi Uela">Ana Vi Uela</name><affiliation><nlm:aff id="A43">Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><affiliation><nlm:aff id="A44">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</nlm:aff></affiliation></author><author><name sortKey="Loehr, Laura R" sort="Loehr, Laura R" uniqKey="Loehr L" first="Laura R." last="Loehr">Laura R. Loehr</name><affiliation><nlm:aff id="A7">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Carolina Center for Genome Sciences University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:aff></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation><nlm:aff id="A45">Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A46">Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:aff></affiliation></author><author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name><affiliation><nlm:aff id="A47">Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.</nlm:aff></affiliation></author><author><name sortKey="Wilk, Jemma B" sort="Wilk, Jemma B" uniqKey="Wilk J" first="Jemma B." last="Wilk">Jemma B. Wilk</name><affiliation><nlm:aff id="A48">Precision Medicine, Pfizer Global Research and Development, Cambridge, MA, USA.</nlm:aff></affiliation></author><author><name sortKey="Tang, Wenbo" sort="Tang, Wenbo" uniqKey="Tang W" first="Wenbo" last="Tang">Wenbo Tang</name><affiliation><nlm:aff id="A49">Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.</nlm:aff></affiliation></author><author><name sortKey="Manichaikul, Ani" sort="Manichaikul, Ani" uniqKey="Manichaikul A" first="Ani" last="Manichaikul">Ani Manichaikul</name><affiliation><nlm:aff id="A50">Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A51">Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA</nlm:aff></affiliation></author><author><name sortKey="Lahousse, Lies" sort="Lahousse, Lies" uniqKey="Lahousse L" first="Lies" last="Lahousse">Lies Lahousse</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="A44">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</nlm:aff></affiliation></author><author><name sortKey="North, Kari E" sort="North, Kari E" uniqKey="North K" first="Kari E." last="North">Kari E. North</name><affiliation><nlm:aff id="A7">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:aff></affiliation></author><author><name sortKey="Rudnicka, Alicja R" sort="Rudnicka, Alicja R" uniqKey="Rudnicka A" first="Alicja R." last="Rudnicka">Alicja R. Rudnicka</name><affiliation><nlm:aff id="A17">Division of Population Health Sciences and Education, St George's, University of London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Hui, Jennie" sort="Hui, Jennie" uniqKey="Hui J" first="Jennie" last="Hui">Jennie Hui</name><affiliation><nlm:aff id="A53">PathWest Laboratory Medicine WA, Nedlands, Australia.</nlm:aff></affiliation></author><author><name sortKey="Gu, Xiangjun" sort="Gu, Xiangjun" uniqKey="Gu X" first="Xiangjun" last="Gu">Xiangjun Gu</name><affiliation><nlm:aff id="A45">Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A46">Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:aff></affiliation></author><author><name sortKey="Lumley, Thomas" sort="Lumley, Thomas" uniqKey="Lumley T" first="Thomas" last="Lumley">Thomas Lumley</name><affiliation><nlm:aff id="A54">Department of Statistics, University of Auckland, Auckland, New Zealand.</nlm:aff></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name><affiliation><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Hastie, Nicholas D" sort="Hastie, Nicholas D" uniqKey="Hastie N" first="Nicholas D." last="Hastie">Nicholas D. Hastie</name><affiliation><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Campbell, Susan" sort="Campbell, Susan" uniqKey="Campbell S" first="Susan" last="Campbell">Susan Campbell</name><affiliation><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Kumar, Rajesh" sort="Kumar, Rajesh" uniqKey="Kumar R" first="Rajesh" last="Kumar">Rajesh Kumar</name><affiliation><nlm:aff id="A55">Northwestern University Feinberg School of Medicine, Chicago, IL, USA.</nlm:aff></affiliation></author><author><name sortKey="Pin, Isabelle" sort="Pin, Isabelle" uniqKey="Pin I" first="Isabelle" last="Pin">Isabelle Pin</name><affiliation><nlm:aff id="A56">Centre Hospitallier Universitaire de Grenoble, Grenoble, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A57">INSERM U823, Institut Albert Bonniot, Grenoble, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A58">Université Joseph Fourier, Grenoble, France.</nlm:aff></affiliation></author><author><name sortKey="Scott, Robert A" sort="Scott, Robert A" uniqKey="Scott R" first="Robert A." last="Scott">Robert A. Scott</name><affiliation><nlm:aff id="A24">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.</nlm:aff></affiliation></author><author><name sortKey="Pietil Inen, Kirsi H" sort="Pietil Inen, Kirsi H" uniqKey="Pietil Inen K" first="Kirsi H." last="Pietil Inen">Kirsi H. Pietil Inen</name><affiliation><nlm:aff id="A27">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A60">Department of Medicine, Division of Internal Medicine, Helsinki University Central Hospital, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Surakka, Ida" sort="Surakka, Ida" uniqKey="Surakka I" first="Ida" last="Surakka">Ida Surakka</name><affiliation><nlm:aff id="A27">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Public Health Genomics Unit, Department of Chronic Disease Prevention, The National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation><nlm:aff id="A62">Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.</nlm:aff></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name><affiliation><nlm:aff id="A14">Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff></affiliation></author><author><name sortKey="Schulz, Holger" sort="Schulz, Holger" uniqKey="Schulz H" first="Holger" last="Schulz">Holger Schulz</name><affiliation><nlm:aff id="A30">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name><affiliation><nlm:aff id="A30">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Davies, Gail" sort="Davies, Gail" uniqKey="Davies G" first="Gail" last="Davies">Gail Davies</name><affiliation><nlm:aff id="A32">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Department of Psychology, The University of Edinburgh, Edinburgh, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A63">Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, Edinburgh, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A64">MRC Institute of Genetics and Molecular Medicine, Edinburgh, UK.</nlm:aff></affiliation></author><author><name sortKey="Vonk, Judith M" sort="Vonk, Judith M" uniqKey="Vonk J" first="Judith M." last="Vonk">Judith M. Vonk</name><affiliation><nlm:aff id="A34">University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A35">GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Wojczynski, Mary" sort="Wojczynski, Mary" uniqKey="Wojczynski M" first="Mary" last="Wojczynski">Mary Wojczynski</name><affiliation><nlm:aff id="A65">Department of Statistical Genomics, Washington University, St. Louis, MO, USA.</nlm:aff></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation><nlm:aff id="A66">National Institute for Health and Welfare, Oulu, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation><nlm:aff id="A37">Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name><affiliation><nlm:aff id="A41">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation><nlm:aff id="A38">Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation><affiliation><nlm:aff id="A69">Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation><affiliation><nlm:aff id="A70">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.</nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="A71">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation><nlm:aff id="A73">Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Hysi, Pirro G" sort="Hysi, Pirro G" uniqKey="Hysi P" first="Pirro G." last="Hysi">Pirro G. Hysi</name><affiliation><nlm:aff id="A43">Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation><nlm:aff id="A11">Iceland Heart Association, Kopavogur, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Morrison, Alanna C" sort="Morrison, Alanna C" uniqKey="Morrison A" first="Alanna C." last="Morrison">Alanna C. Morrison</name><affiliation><nlm:aff id="A74">School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:aff></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name><affiliation><nlm:aff id="A75">Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.</nlm:aff></affiliation></author><author><name sortKey="Gao, Wei" sort="Gao, Wei" uniqKey="Gao W" first="Wei" last="Gao">Wei Gao</name><affiliation><nlm:aff id="A77">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.</nlm:aff></affiliation></author><author><name sortKey="Postma, Dirkje S" sort="Postma, Dirkje S" uniqKey="Postma D" first="Dirkje S." last="Postma">Dirkje S. Postma</name><affiliation><nlm:aff id="A35">GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A78">University of Groningen, University Medical Center Groningen, Department of Pulmonology, Groningen, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="White, Wendy B" sort="White, Wendy B" uniqKey="White W" first="Wendy B." last="White">Wendy B. White</name><affiliation><nlm:aff id="A79">Tougaloo College, Jackson, MS, USA.</nlm:aff></affiliation></author><author><name sortKey="Rich, Stephen S" sort="Rich, Stephen S" uniqKey="Rich S" first="Stephen S." last="Rich">Stephen S. Rich</name><affiliation><nlm:aff id="A50">Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A51">Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name><affiliation><nlm:aff id="A11">Iceland Heart Association, Kopavogur, Iceland.</nlm:aff></affiliation><affiliation><nlm:aff id="A12">University of Iceland, Reykjavik, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Couper, David" sort="Couper, David" uniqKey="Couper D" first="David" last="Couper">David Couper</name><affiliation><nlm:aff id="A80">Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:aff></affiliation></author><author><name sortKey="Smith, Lewis J" sort="Smith, Lewis J" uniqKey="Smith L" first="Lewis J." last="Smith">Lewis J. Smith</name><affiliation><nlm:aff id="A55">Northwestern University Feinberg School of Medicine, Chicago, IL, USA.</nlm:aff></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name><affiliation><nlm:aff id="A6">Department of Medicine, University of Washington, Seattle, WA, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A47">Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A81">Department of Epidemiology, University of Washington, Seattle, WA, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A82">Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.</nlm:aff></affiliation></author><author><name sortKey="Lohman, Kurt" sort="Lohman, Kurt" uniqKey="Lohman K" first="Kurt" last="Lohman">Kurt Lohman</name><affiliation><nlm:aff id="A83">Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.</nlm:aff></affiliation></author><author><name sortKey="Burchard, Esteban G" sort="Burchard, Esteban G" uniqKey="Burchard E" first="Esteban G." last="Burchard">Esteban G. Burchard</name><affiliation><nlm:aff id="A84">Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, CA, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A85">Department of Medicine, University of California, San Francisco, CA, USA.</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G." last="Uitterlinden">André G. Uitterlinden</name><affiliation><nlm:aff id="A71">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Garcia, Melissa" sort="Garcia, Melissa" uniqKey="Garcia M" first="Melissa" last="Garcia">Melissa Garcia</name><affiliation><nlm:aff id="A44">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</nlm:aff></affiliation></author><author><name sortKey="Joubert, Bonnie R" sort="Joubert, Bonnie R" uniqKey="Joubert B" first="Bonnie R." last="Joubert">Bonnie R. Joubert</name><affiliation><nlm:aff id="A86">Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.</nlm:aff></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L." last="Mcardle">Wendy L. Mcardle</name><affiliation><nlm:aff id="A87">School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</nlm:aff></affiliation></author><author><name sortKey="Musk, A Bill" sort="Musk, A Bill" uniqKey="Musk A" first="A. Bill" last="Musk">A. Bill Musk</name><affiliation><nlm:aff id="A88">Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Australia.</nlm:aff></affiliation></author><author><name sortKey="Hansel, Nadia" sort="Hansel, Nadia" uniqKey="Hansel N" first="Nadia" last="Hansel">Nadia Hansel</name><affiliation><nlm:aff id="A89">Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.</nlm:aff></affiliation></author><author><name sortKey="Heckbert, Susan R" sort="Heckbert, Susan R" uniqKey="Heckbert S" first="Susan R." last="Heckbert">Susan R. Heckbert</name><affiliation><nlm:aff id="A47">Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A81">Department of Epidemiology, University of Washington, Seattle, WA, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A82">Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.</nlm:aff></affiliation></author><author><name sortKey="Zgaga, Lina" sort="Zgaga, Lina" uniqKey="Zgaga L" first="Lina" last="Zgaga">Lina Zgaga</name><affiliation><nlm:aff id="A90">Department of Public Health and Primary Care, Trinity College Dublin, Dublin, Ireland.</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Adrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Van Meurs, Joyce B J" sort="Van Meurs, Joyce B J" uniqKey="Van Meurs J" first="Joyce B. J." last="Van Meurs">Joyce B. J. Van Meurs</name><affiliation><nlm:aff id="A71">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Navarro, Pau" sort="Navarro, Pau" uniqKey="Navarro P" first="Pau" last="Navarro">Pau Navarro</name><affiliation><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="A92">Centre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Oh, Yeon Mok" sort="Oh, Yeon Mok" uniqKey="Oh Y" first="Yeon-Mok" last="Oh">Yeon-Mok Oh</name><affiliation><nlm:aff id="A93">Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.</nlm:aff></affiliation><affiliation><nlm:aff id="A94">Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.</nlm:aff></affiliation></author><author><name sortKey="Redline, Susan" sort="Redline, Susan" uniqKey="Redline S" first="Susan" last="Redline">Susan Redline</name><affiliation><nlm:aff id="A95">Department of Medicine, Brigham Women's Hospital, Boston, MA, USA.</nlm:aff></affiliation></author><author><name sortKey="Jarvis, Deborah" sort="Jarvis, Deborah" uniqKey="Jarvis D" first="Deborah" last="Jarvis">Deborah Jarvis</name><affiliation><nlm:aff id="A22">Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A96">MRC-PHE Centre for Environment & Health, Imperial College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="A24">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.</nlm:aff></affiliation></author><author><name sortKey="Rantanen, Taina" sort="Rantanen, Taina" uniqKey="Rantanen T" first="Taina" last="Rantanen">Taina Rantanen</name><affiliation><nlm:aff id="A97">Gerontology Research Centre, Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland.</nlm:aff></affiliation></author><author><name sortKey="O Onnor, George T" sort="O Onnor, George T" uniqKey="O Onnor G" first="George T." last="O Onnor">George T. O Onnor</name><affiliation><nlm:aff id="A98">Pulmonary Center, Boston University School of Medicine, Boston, MA, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A99">The NHLBI's Framingham Heart Study, Framingham, MA, USA.</nlm:aff></affiliation></author><author><name sortKey="Ripatti, Samuli" sort="Ripatti, Samuli" uniqKey="Ripatti S" first="Samuli" last="Ripatti">Samuli Ripatti</name><affiliation><nlm:aff id="A27">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Public Health Genomics Unit, Department of Chronic Disease Prevention, The National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A100">Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name><affiliation><nlm:aff id="A14">Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff></affiliation></author><author><name sortKey="Karrasch, Stefan" sort="Karrasch, Stefan" uniqKey="Karrasch S" first="Stefan" last="Karrasch">Stefan Karrasch</name><affiliation><nlm:aff id="A30">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A101">Institute for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universität, Munich, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A102">Institute of General Practice, University Hospital Klinikum rechts der Isar, Technische Universität München, Munich, Germany.</nlm:aff></affiliation></author><author><name sortKey="Grallert, Harald" sort="Grallert, Harald" uniqKey="Grallert H" first="Harald" last="Grallert">Harald Grallert</name><affiliation><nlm:aff id="A103">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Gaddis, Nathan C" sort="Gaddis, Nathan C" uniqKey="Gaddis N" first="Nathan C." last="Gaddis">Nathan C. Gaddis</name><affiliation><nlm:aff id="A104">Research Computing Division, Research Triangle Institute International, Research Triangle Park, NC, USA.</nlm:aff></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><affiliation><nlm:aff id="A32">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A105">Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.</nlm:aff></affiliation></author><author><name sortKey="Wijmenga, Cisca" sort="Wijmenga, Cisca" uniqKey="Wijmenga C" first="Cisca" last="Wijmenga">Cisca Wijmenga</name><affiliation><nlm:aff id="A106">Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Minster, Ryan L" sort="Minster, Ryan L" uniqKey="Minster R" first="Ryan L." last="Minster">Ryan L. Minster</name><affiliation><nlm:aff id="A107">Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.</nlm:aff></affiliation></author><author><name sortKey="Lederer, David J" sort="Lederer, David J" uniqKey="Lederer D" first="David J." last="Lederer">David J. Lederer</name><affiliation><nlm:aff id="A10">Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A108">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.</nlm:aff></affiliation></author><author><name sortKey="Pekkanen, Juha" sort="Pekkanen, Juha" uniqKey="Pekkanen J" first="Juha" last="Pekkanen">Juha Pekkanen</name><affiliation><nlm:aff id="A109">Department of Environmental Health, National Institute for Health and Welfare (THL), Kuopio, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A110">Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.</nlm:aff></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation><nlm:aff id="A37">Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="A41">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Morris, Andrew P" sort="Morris, Andrew P" uniqKey="Morris A" first="Andrew P." last="Morris">Andrew P. Morris</name><affiliation><nlm:aff id="A70">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.</nlm:aff></affiliation></author><author><name sortKey="Gl Ser, Sven" sort="Gl Ser, Sven" uniqKey="Gl Ser S" first="Sven" last="Gl Ser">Sven Gl Ser</name><affiliation><nlm:aff id="A9">Department of Internal Medicine B - Pneumology, Cardiology, Intensive Care and Infectious Diseases, University Hospital Greifswald, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Hammond, Christopher J" sort="Hammond, Christopher J" uniqKey="Hammond C" first="Christopher J." last="Hammond">Christopher J. Hammond</name><affiliation><nlm:aff id="A43">Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Burkart, Kristin M" sort="Burkart, Kristin M" uniqKey="Burkart K" first="Kristin M." last="Burkart">Kristin M. Burkart</name><affiliation><nlm:aff id="A10">Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff></affiliation></author><author><name sortKey="Beilby, John" sort="Beilby, John" uniqKey="Beilby J" first="John" last="Beilby">John Beilby</name><affiliation><nlm:aff id="A53">PathWest Laboratory Medicine WA, Nedlands, Australia.</nlm:aff></affiliation></author><author><name sortKey="Kritchevsky, Stephen B" sort="Kritchevsky, Stephen B" uniqKey="Kritchevsky S" first="Stephen B." last="Kritchevsky">Stephen B. Kritchevsky</name><affiliation><nlm:aff id="A111">Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, USA.</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="A11">Iceland Heart Association, Kopavogur, Iceland.</nlm:aff></affiliation><affiliation><nlm:aff id="A12">University of Iceland, Reykjavik, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Hancock, Dana B" sort="Hancock, Dana B" uniqKey="Hancock D" first="Dana B." last="Hancock">Dana B. Hancock</name><affiliation><nlm:aff id="A112">Behavioral Health Epidemiology Program, Research Triangle Institute International, Research Triangle Park, NC, USA.</nlm:aff></affiliation></author><author><name sortKey="Williams, O Dale" sort="Williams, O Dale" uniqKey="Williams O" first="O. Dale" last="Williams">O. Dale Williams</name><affiliation><nlm:aff id="A113">Florida International University, Miami, FL, USA.</nlm:aff></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation><nlm:aff id="A114">Department of Public Health, Medical School, University of Split, Split, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Zemunik, Tatijana" sort="Zemunik, Tatijana" uniqKey="Zemunik T" first="Tatijana" last="Zemunik">Tatijana Zemunik</name><affiliation><nlm:aff id="A115">Department of Medical Biology, Medical School, University of Split, Split, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name><affiliation><nlm:aff id="A114">Department of Public Health, Medical School, University of Split, Split, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Petrini, Marcy F" sort="Petrini, Marcy F" uniqKey="Petrini M" first="Marcy F." last="Petrini">Marcy F. Petrini</name><affiliation><nlm:aff id="A116">Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.</nlm:aff></affiliation></author><author><name sortKey="Wjst, Matthias" sort="Wjst, Matthias" uniqKey="Wjst M" first="Matthias" last="Wjst">Matthias Wjst</name><affiliation><nlm:aff id="A117">Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München (HMGU), München, Germany.</nlm:aff></affiliation></author><author><name sortKey="Kim, Woo Jin" sort="Kim, Woo Jin" uniqKey="Kim W" first="Woo Jin" last="Kim">Woo Jin Kim</name><affiliation><nlm:aff id="A118">Department of Internal Medicine, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea.</nlm:aff></affiliation><affiliation><nlm:aff id="A119">Environmental Health Center, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea.</nlm:aff></affiliation></author><author><name sortKey="Porteous, David J" sort="Porteous, David J" uniqKey="Porteous D" first="David J." last="Porteous">David J. Porteous</name><affiliation><nlm:aff id="A63">Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, Edinburgh, UK.</nlm:aff></affiliation></author><author><name sortKey="Scotland, Generation" sort="Scotland, Generation" uniqKey="Scotland G" first="Generation" last="Scotland">Generation Scotland</name><affiliation><nlm:aff id="A76">Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.</nlm:aff></affiliation></author><author><name sortKey="Smith, Blair H" sort="Smith, Blair H" uniqKey="Smith B" first="Blair H." last="Smith">Blair H. Smith</name><affiliation><nlm:aff id="A75">Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA.</nlm:aff></affiliation></author><author><name sortKey="Viljanen, Anne" sort="Viljanen, Anne" uniqKey="Viljanen A" first="Anne" last="Viljanen">Anne Viljanen</name><affiliation><nlm:aff id="A97">Gerontology Research Centre, Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland.</nlm:aff></affiliation></author><author><name sortKey="Heliovaara, Markku" sort="Heliovaara, Markku" uniqKey="Heliovaara M" first="Markku" last="Heliövaara">Markku Heliövaara</name><affiliation><nlm:aff id="A26">The National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Attia, John R" sort="Attia, John R" uniqKey="Attia J" first="John R." last="Attia">John R. Attia</name><affiliation><nlm:aff id="A14">Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff></affiliation></author><author><name sortKey="Sayers, Ian" sort="Sayers, Ian" uniqKey="Sayers I" first="Ian" last="Sayers">Ian Sayers</name><affiliation><nlm:aff id="A120">Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, UK.</nlm:aff></affiliation></author><author><name sortKey="Hampel, Regina" sort="Hampel, Regina" uniqKey="Hampel R" first="Regina" last="Hampel">Regina Hampel</name><affiliation><nlm:aff id="A121">Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation><nlm:aff id="A31">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><affiliation><nlm:aff id="A32">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Department of Psychology, The University of Edinburgh, Edinburgh, UK.</nlm:aff></affiliation></author><author><name sortKey="Boezen, H Marike" sort="Boezen, H Marike" uniqKey="Boezen H" first="H. Marike" last="Boezen">H. Marike Boezen</name><affiliation><nlm:aff id="A34">University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A35">GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Newman, Anne" sort="Newman, Anne" uniqKey="Newman A" first="Anne" last="Newman">Anne Newman</name><affiliation><nlm:aff id="A122">Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, PA, USA.</nlm:aff></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation><nlm:aff id="A23">Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A123">Institute of Health Sciences, University of Oulu, Oulu, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A124">Biocenter Oulu, University of Oulu, Oulu, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A125">Unit of Primary Care, Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A126">Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="A41">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation><nlm:aff id="A69">Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Stricker, Bruno H" sort="Stricker, Bruno H" uniqKey="Stricker B" first="Bruno H." last="Stricker">Bruno H. Stricker</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Netherlands Health Care Inspectorate, The Hague, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A71">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:aff id="A127">Department for Genetics and Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D." last="Spector">Timothy D. Spector</name><affiliation><nlm:aff id="A43">Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Melen, Erik" sort="Melen, Erik" uniqKey="Melen E" first="Erik" last="Melén">Erik Melén</name><affiliation><nlm:aff id="A128">Institute of Environmental Medicine, Karolinska Institutet and Sachs’ Children’s Hospital, Stockholm, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Peters, Marjolein J" sort="Peters, Marjolein J" uniqKey="Peters M" first="Marjolein J." last="Peters">Marjolein J. Peters</name><affiliation><nlm:aff id="A71">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Lange, Leslie A" sort="Lange, Leslie A" uniqKey="Lange L" first="Leslie A." last="Lange">Leslie A. Lange</name><affiliation><nlm:aff id="A13">Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.</nlm:aff></affiliation></author><author><name sortKey="Barr, R Graham" sort="Barr, R Graham" uniqKey="Barr R" first="R. Graham" last="Barr">R. Graham Barr</name><affiliation><nlm:aff id="A108">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.</nlm:aff></affiliation></author><author><name sortKey="Bracke, Ken R" sort="Bracke, Ken R" uniqKey="Bracke K" first="Ken R." last="Bracke">Ken R. Bracke</name><affiliation><nlm:aff id="A52">Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:aff></affiliation></author><author><name sortKey="Verhamme, Fien M" sort="Verhamme, Fien M" uniqKey="Verhamme F" first="Fien M." last="Verhamme">Fien M. Verhamme</name><affiliation><nlm:aff id="A52">Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:aff></affiliation></author><author><name sortKey="Sung, Joohon" sort="Sung, Joohon" uniqKey="Sung J" first="Joohon" last="Sung">Joohon Sung</name><affiliation><nlm:aff id="A16">Institute of Health and Environment, Seoul National University, Seoul, South Korea.</nlm:aff></affiliation><affiliation><nlm:aff id="A129">Complex Disease & Genetic Epidemiology Branch, Department of Epidemiology, Seoul National University School of Public Health, Seoul, South Korea.</nlm:aff></affiliation></author><author><name sortKey="Hiemstra, Pieter S" sort="Hiemstra, Pieter S" uniqKey="Hiemstra P" first="Pieter S." last="Hiemstra">Pieter S. Hiemstra</name><affiliation><nlm:aff id="A130">Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Cassano, Patricia A" sort="Cassano, Patricia A" uniqKey="Cassano P" first="Patricia A." last="Cassano">Patricia A. Cassano</name><affiliation><nlm:aff id="A49">Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A131">Department of Public Health, Division of Biostatistics and Epidemiology, Weill Cornell Medical College, New York, NY, USA.</nlm:aff></affiliation></author><author><name sortKey="Sood, Akshay" sort="Sood, Akshay" uniqKey="Sood A" first="Akshay" last="Sood">Akshay Sood</name><affiliation><nlm:aff id="A132">University of New Mexico Health Sciences Center School of Medicine, Albuquerque, NM, USA.</nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Dupuis, Josee" sort="Dupuis, Josee" uniqKey="Dupuis J" first="Josée" last="Dupuis">Josée Dupuis</name><affiliation><nlm:aff id="A77">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A99">The NHLBI's Framingham Heart Study, Framingham, MA, USA.</nlm:aff></affiliation></author><author><name sortKey="Hall, Ian P" sort="Hall, Ian P" uniqKey="Hall I" first="Ian P." last="Hall">Ian P. Hall</name><affiliation><nlm:aff id="A120">Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, UK.</nlm:aff></affiliation></author><author><name sortKey="Brusselle, Guy G" sort="Brusselle, Guy G" uniqKey="Brusselle G" first="Guy G." last="Brusselle">Guy G. Brusselle</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:aff></affiliation><affiliation><nlm:aff id="A133">Department of Respiratory Medicine, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Tobin, Martin D" sort="Tobin, Martin D" uniqKey="Tobin M" first="Martin D." last="Tobin">Martin D. Tobin</name><affiliation><nlm:aff id="A3">Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A4">National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK.</nlm:aff></affiliation></author><author><name sortKey="London, Stephanie J" sort="London, Stephanie J" uniqKey="London S" first="Stephanie J." last="London">Stephanie J. London</name><affiliation><nlm:aff id="A86">Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.</nlm:aff></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P3">Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (<italic>P</italic> < 5 × 10<sup>−8</sup>) with FVC in or near <italic>EFEMP1, BMP6, MIR-129-2/HSD17B12, PRDM11, WWOX</italic>, and <italic>KCNJ2</italic>. Two (<italic>GSTCD</italic> and <italic>PTCH1</italic>) loci previously associated with spirometric measures were related to FVC. Newly implicated regions were followed-up in samples of African American, Korean, Chinese, and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and pathogenesis of restrictive lung disease.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id><journal-id journal-id-type="pubmed-jr-id">2419</journal-id><journal-id journal-id-type="nlm-ta">Nat Genet</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Genet.</journal-id><journal-title-group><journal-title>Nature genetics</journal-title></journal-title-group><issn pub-type="ppub">1061-4036</issn><issn pub-type="epub">1546-1718</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24929828</article-id><article-id pub-id-type="pmc">4140093</article-id><article-id pub-id-type="doi">10.1038/ng.3011</article-id><article-id pub-id-type="manuscript">NIHMS608728</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Genome-wide association analysis identifies six new loci associated with forced vital capacity</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Loth</surname><given-names>Daan W.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib 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contrib-type="author"><name><surname>Sood</surname><given-names>Akshay</given-names></name><xref ref-type="aff" rid="A132">132</xref><xref ref-type="author-notes" rid="FN2">**</xref></contrib><contrib contrib-type="author"><name><surname>Hayward</surname><given-names>Caroline</given-names></name><xref ref-type="aff" rid="A21">21</xref><xref ref-type="author-notes" rid="FN2">**</xref></contrib><contrib contrib-type="author"><name><surname>Dupuis</surname><given-names>Josée</given-names></name><xref ref-type="aff" rid="A77">77</xref><xref ref-type="aff" rid="A99">99</xref><xref ref-type="author-notes" rid="FN2">**</xref></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>Ian P.</given-names></name><xref ref-type="aff" rid="A120">120</xref><xref ref-type="author-notes" rid="FN2">**</xref></contrib><contrib contrib-type="author"><name><surname>Brusselle</surname><given-names>Guy G.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A52">52</xref><xref ref-type="aff" rid="A133">133</xref><xref ref-type="author-notes" rid="FN2">**</xref></contrib><contrib contrib-type="author"><name><surname>Tobin</surname><given-names>Martin D.</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref><xref ref-type="author-notes" rid="FN2">**</xref></contrib><contrib contrib-type="author"><name><surname>London</surname><given-names>Stephanie J.</given-names></name><xref ref-type="aff" rid="A86">86</xref><xref ref-type="author-notes" rid="FN2">**</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</aff><aff id="A2"><label>2</label>Netherlands Health Care Inspectorate, The Hague, The Netherlands.</aff><aff id="A3"><label>3</label>Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.</aff><aff id="A4"><label>4</label>National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK.</aff><aff id="A5"><label>5</label>Computational Medicine Core, Center for Lung Biology, University of Washington, Seattle, WA, USA.</aff><aff id="A6"><label>6</label>Department of Medicine, University of Washington, Seattle, WA, USA.</aff><aff id="A7"><label>7</label>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</aff><aff id="A8"><label>8</label>Carolina Center for Genome Sciences University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</aff><aff id="A9"><label>9</label>Department of Internal Medicine B - Pneumology, Cardiology, Intensive Care and Infectious Diseases, University Hospital Greifswald, Greifswald, Germany.</aff><aff id="A10"><label>10</label>Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</aff><aff id="A11"><label>11</label>Iceland Heart Association, Kopavogur, Iceland.</aff><aff id="A12"><label>12</label>University of Iceland, Reykjavik, Iceland.</aff><aff id="A13"><label>13</label>Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.</aff><aff id="A14"><label>14</label>Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.</aff><aff id="A15"><label>15</label>Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</aff><aff id="A16"><label>16</label>Institute of Health and Environment, Seoul National University, Seoul, South Korea.</aff><aff id="A17"><label>17</label>Division of Population Health Sciences and Education, St George's, University of London, London, UK.</aff><aff id="A18"><label>18</label>Department of Pulmonary Physiology and Sleep Medicine/West Australian Sleep Disorders Research Institute, Nedlands, Australia.</aff><aff id="A19"><label>19</label>School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia.</aff><aff id="A20"><label>20</label>Busselton Population Medical Research Institute, Busselton, Australia.</aff><aff id="A21"><label>21</label>MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</aff><aff id="A22"><label>22</label>Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, UK.</aff><aff id="A23"><label>23</label>Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.</aff><aff id="A24"><label>24</label>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.</aff><aff id="A25"><label>25</label>Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland.</aff><aff id="A26"><label>26</label>The National Institute for Health and Welfare (THL), Helsinki, Finland.</aff><aff id="A27"><label>27</label>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</aff><aff id="A28"><label>28</label>Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.</aff><aff id="A29"><label>29</label>Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland.</aff><aff id="A30"><label>30</label>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</aff><aff id="A31"><label>31</label>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</aff><aff id="A32"><label>32</label>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.</aff><aff id="A33"><label>33</label>Department of Psychology, The University of Edinburgh, Edinburgh, UK.</aff><aff id="A34"><label>34</label>University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.</aff><aff id="A35"><label>35</label>GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</aff><aff id="A36"><label>36</label>Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.</aff><aff id="A37"><label>37</label>Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.</aff><aff id="A38"><label>38</label>Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</aff><aff id="A39"><label>39</label>Haukeland University Hospital, Bergen, Norway.</aff><aff id="A40"><label>40</label>Department Clinical Sciences, University of Bergen, Bergen, Norway.</aff><aff id="A41"><label>41</label>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</aff><aff id="A42"><label>42</label>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</aff><aff id="A43"><label>43</label>Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.</aff><aff id="A44"><label>44</label>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</aff><aff id="A45"><label>45</label>Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.</aff><aff id="A46"><label>46</label>Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.</aff><aff id="A47"><label>47</label>Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.</aff><aff id="A48"><label>48</label>Precision Medicine, Pfizer Global Research and Development, Cambridge, MA, USA.</aff><aff id="A49"><label>49</label>Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.</aff><aff id="A50"><label>50</label>Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.</aff><aff id="A51"><label>51</label>Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA</aff><aff id="A52"><label>52</label>Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</aff><aff id="A53"><label>53</label>PathWest Laboratory Medicine WA, Nedlands, Australia.</aff><aff id="A54"><label>54</label>Department of Statistics, University of Auckland, Auckland, New Zealand.</aff><aff id="A55"><label>55</label>Northwestern University Feinberg School of Medicine, Chicago, IL, USA.</aff><aff id="A56"><label>56</label>Centre Hospitallier Universitaire de Grenoble, Grenoble, France.</aff><aff id="A57"><label>57</label>INSERM U823, Institut Albert Bonniot, Grenoble, France.</aff><aff id="A58"><label>58</label>Université Joseph Fourier, Grenoble, France.</aff><aff id="A59"><label>59</label>Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.</aff><aff id="A60"><label>60</label>Department of Medicine, Division of Internal Medicine, Helsinki University Central Hospital, Helsinki, Finland.</aff><aff id="A61"><label>61</label>Public Health Genomics Unit, Department of Chronic Disease Prevention, The National Institute for Health and Welfare (THL), Helsinki, Finland.</aff><aff id="A62"><label>62</label>Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.</aff><aff id="A63"><label>63</label>Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, Edinburgh, UK.</aff><aff id="A64"><label>64</label>MRC Institute of Genetics and Molecular Medicine, Edinburgh, UK.</aff><aff id="A65"><label>65</label>Department of Statistical Genomics, Washington University, St. Louis, MO, USA.</aff><aff id="A66"><label>66</label>National Institute for Health and Welfare, Oulu, Finland.</aff><aff id="A67"><label>67</label>Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, Oulu, Finland.</aff><aff id="A68"><label>68</label>Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.</aff><aff id="A69"><label>69</label>Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</aff><aff id="A70"><label>70</label>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.</aff><aff id="A71"><label>71</label>Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.</aff><aff id="A72"><label>72</label>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</aff><aff id="A73"><label>73</label>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany</aff><aff id="A74"><label>74</label>School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.</aff><aff id="A75"><label>75</label>Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA.</aff><aff id="A76"><label>76</label>Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.</aff><aff id="A77"><label>77</label>Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.</aff><aff id="A78"><label>78</label>University of Groningen, University Medical Center Groningen, Department of Pulmonology, Groningen, The Netherlands.</aff><aff id="A79"><label>79</label>Tougaloo College, Jackson, MS, USA.</aff><aff id="A80"><label>80</label>Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</aff><aff id="A81"><label>81</label>Department of Epidemiology, University of Washington, Seattle, WA, USA.</aff><aff id="A82"><label>82</label>Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.</aff><aff id="A83"><label>83</label>Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.</aff><aff id="A84"><label>84</label>Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, CA, USA.</aff><aff id="A85"><label>85</label>Department of Medicine, University of California, San Francisco, CA, USA.</aff><aff id="A86"><label>86</label>Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.</aff><aff id="A87"><label>87</label>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</aff><aff id="A88"><label>88</label>Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Australia.</aff><aff id="A89"><label>89</label>Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.</aff><aff id="A90"><label>90</label>Department of Public Health and Primary Care, Trinity College Dublin, Dublin, Ireland.</aff><aff id="A91"><label>91</label>Adrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia.</aff><aff id="A92"><label>92</label>Centre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, Scotland, UK.</aff><aff id="A93"><label>93</label>Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.</aff><aff id="A94"><label>94</label>Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.</aff><aff id="A95"><label>95</label>Department of Medicine, Brigham Women's Hospital, Boston, MA, USA.</aff><aff id="A96"><label>96</label>MRC-PHE Centre for Environment & Health, Imperial College London, London, UK.</aff><aff id="A97"><label>97</label>Gerontology Research Centre, Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland.</aff><aff id="A98"><label>98</label>Pulmonary Center, Boston University School of Medicine, Boston, MA, USA.</aff><aff id="A99"><label>99</label>The NHLBI's Framingham Heart Study, Framingham, MA, USA.</aff><aff id="A100"><label>100</label>Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.</aff><aff id="A101"><label>101</label>Institute for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universität, Munich, Germany.</aff><aff id="A102"><label>102</label>Institute of General Practice, University Hospital Klinikum rechts der Isar, Technische Universität München, Munich, Germany.</aff><aff id="A103"><label>103</label>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany.</aff><aff id="A104"><label>104</label>Research Computing Division, Research Triangle Institute International, Research Triangle Park, NC, USA.</aff><aff id="A105"><label>105</label>Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.</aff><aff id="A106"><label>106</label>Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.</aff><aff id="A107"><label>107</label>Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.</aff><aff id="A108"><label>108</label>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.</aff><aff id="A109"><label>109</label>Department of Environmental Health, National Institute for Health and Welfare (THL), Kuopio, Finland.</aff><aff id="A110"><label>110</label>Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.</aff><aff id="A111"><label>111</label>Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, USA.</aff><aff id="A112"><label>112</label>Behavioral Health Epidemiology Program, Research Triangle Institute International, Research Triangle Park, NC, USA.</aff><aff id="A113"><label>113</label>Florida International University, Miami, FL, USA.</aff><aff id="A114"><label>114</label>Department of Public Health, Medical School, University of Split, Split, Croatia.</aff><aff id="A115"><label>115</label>Department of Medical Biology, Medical School, University of Split, Split, Croatia.</aff><aff id="A116"><label>116</label>Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.</aff><aff id="A117"><label>117</label>Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München (HMGU), München, Germany.</aff><aff id="A118"><label>118</label>Department of Internal Medicine, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea.</aff><aff id="A119"><label>119</label>Environmental Health Center, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea.</aff><aff id="A120"><label>120</label>Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, UK.</aff><aff id="A121"><label>121</label>Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</aff><aff id="A122"><label>122</label>Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, PA, USA.</aff><aff id="A123"><label>123</label>Institute of Health Sciences, University of Oulu, Oulu, Finland.</aff><aff id="A124"><label>124</label>Biocenter Oulu, University of Oulu, Oulu, Finland.</aff><aff id="A125"><label>125</label>Unit of Primary Care, Oulu University Hospital, Oulu, Finland</aff><aff id="A126"><label>126</label>Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland.</aff><aff id="A127"><label>127</label>Department for Genetics and Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.</aff><aff id="A128"><label>128</label>Institute of Environmental Medicine, Karolinska Institutet and Sachs’ Children’s Hospital, Stockholm, Sweden.</aff><aff id="A129"><label>129</label>Complex Disease & Genetic Epidemiology Branch, Department of Epidemiology, Seoul National University School of Public Health, Seoul, South Korea.</aff><aff id="A130"><label>130</label>Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.</aff><aff id="A131"><label>131</label>Department of Public Health, Division of Biostatistics and Epidemiology, Weill Cornell Medical College, New York, NY, USA.</aff><aff id="A132"><label>132</label>University of New Mexico Health Sciences Center School of Medicine, Albuquerque, NM, USA.</aff><aff id="A133"><label>133</label>Department of Respiratory Medicine, Erasmus MC, Rotterdam, The Netherlands.</aff><author-notes><corresp id="cor1">Correspondence regarding this manuscript should be directed to: Stephanie J. London, <email>london2@niehs.nih.gov</email>, Martin D. Tobin, <email>mt47@le.ac.uk</email></corresp><fn id="FN1" fn-type="equal"><label>*</label><p id="P1">These authors contributed equally to this work</p></fn><fn id="FN2"><label>**</label><p id="P2">These authors jointly directed this work</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>27</day><month>6</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>15</day><month>6</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>1</month><year>2015</year></pub-date><volume>46</volume><issue>7</issue><fpage>669</fpage><lpage>677</lpage><pmc-comment>elocation-id from pubmed: 10.1038/ng.3011</pmc-comment>
<abstract><p id="P3">Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (<italic>P</italic> < 5 × 10<sup>−8</sup>) with FVC in or near <italic>EFEMP1, BMP6, MIR-129-2/HSD17B12, PRDM11, WWOX</italic>, and <italic>KCNJ2</italic>. Two (<italic>GSTCD</italic> and <italic>PTCH1</italic>) loci previously associated with spirometric measures were related to FVC. Newly implicated regions were followed-up in samples of African American, Korean, Chinese, and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and pathogenesis of restrictive lung disease.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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