Serveur d'exploration sur les relations entre la France et l'Australie

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<title xml:lang="en">Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci</title>
<author>
<name sortKey="Cortes, Adrian" sort="Cortes, Adrian" uniqKey="Cortes A" first="Adrian" last="Cortes">Adrian Cortes</name>
<affiliation>
<nlm:aff id="A1">University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hadler, Johanna" sort="Hadler, Johanna" uniqKey="Hadler J" first="Johanna" last="Hadler">Johanna Hadler</name>
<affiliation>
<nlm:aff id="A1">University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Pointon, Jenny P" sort="Pointon, Jenny P" uniqKey="Pointon J" first="Jenny P" last="Pointon">Jenny P. Pointon</name>
<affiliation>
<nlm:aff id="A2">National Institute for Health Research (NIHR) Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford, UK</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Robinson, Philip C" sort="Robinson, Philip C" uniqKey="Robinson P" first="Philip C" last="Robinson">Philip C. Robinson</name>
<affiliation>
<nlm:aff id="A1">University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Karaderi, Tugce" sort="Karaderi, Tugce" uniqKey="Karaderi T" first="Tugce" last="Karaderi">Tugce Karaderi</name>
<affiliation>
<nlm:aff id="A2">National Institute for Health Research (NIHR) Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford, UK</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Leo, Paul" sort="Leo, Paul" uniqKey="Leo P" first="Paul" last="Leo">Paul Leo</name>
<affiliation>
<nlm:aff id="A1">University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Cremin, Katie" sort="Cremin, Katie" uniqKey="Cremin K" first="Katie" last="Cremin">Katie Cremin</name>
<affiliation>
<nlm:aff id="A1">University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Pryce, Karena" sort="Pryce, Karena" uniqKey="Pryce K" first="Karena" last="Pryce">Karena Pryce</name>
<affiliation>
<nlm:aff id="A1">University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Harris, Jessica" sort="Harris, Jessica" uniqKey="Harris J" first="Jessica" last="Harris">Jessica Harris</name>
<affiliation>
<nlm:aff id="A1">University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lee, Seunghun" sort="Lee, Seunghun" uniqKey="Lee S" first="Seunghun" last="Lee">Seunghun Lee</name>
<affiliation>
<nlm:aff id="A3">Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Joo, Kyung Bin" sort="Joo, Kyung Bin" uniqKey="Joo K" first="Kyung Bin" last="Joo">Kyung Bin Joo</name>
<affiliation>
<nlm:aff id="A3">Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Shim, Seung Cheol" sort="Shim, Seung Cheol" uniqKey="Shim S" first="Seung-Cheol" last="Shim">Seung-Cheol Shim</name>
<affiliation>
<nlm:aff id="A4">Department of Medicine, Division of Rheumatology, Eulji University Hospital, Daejeon, Republic of Korea</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Weisman, Michael" sort="Weisman, Michael" uniqKey="Weisman M" first="Michael" last="Weisman">Michael Weisman</name>
<affiliation>
<nlm:aff id="A5">Department of Medicine/Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ward, Michael" sort="Ward, Michael" uniqKey="Ward M" first="Michael" last="Ward">Michael Ward</name>
<affiliation>
<nlm:aff id="A6">National Institute of Arthritis and Musculoskeletal and Skin Diseases, US National Institutes of Health, Bethesda, Maryland, USA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Zhou, Xiaodong" sort="Zhou, Xiaodong" uniqKey="Zhou X" first="Xiaodong" last="Zhou">Xiaodong Zhou</name>
<affiliation>
<nlm:aff id="A7">Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, Texas, USA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Garchon, Henri Jean" sort="Garchon, Henri Jean" uniqKey="Garchon H" first="Henri-Jean" last="Garchon">Henri-Jean Garchon</name>
<affiliation>
<nlm:aff id="A8">Institut Cochin, Université Paris–Descartes, Centre National de Recherche Scientifique (CNRS) Unité Mixte de Recherhce (UMR) 8104, Institut National de la Santé et de la Recherche Médicale (INSERM) U1016, Paris, France</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A9">Division of Rheumatology, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris, Versailles-Saint-Quentin en Yvelines University, Boulogne-Billancourt, France</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Chiocchia, Gilles" sort="Chiocchia, Gilles" uniqKey="Chiocchia G" first="Gilles" last="Chiocchia">Gilles Chiocchia</name>
<affiliation>
<nlm:aff id="A8">Institut Cochin, Université Paris–Descartes, Centre National de Recherche Scientifique (CNRS) Unité Mixte de Recherhce (UMR) 8104, Institut National de la Santé et de la Recherche Médicale (INSERM) U1016, Paris, France</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Nossent, Johannes" sort="Nossent, Johannes" uniqKey="Nossent J" first="Johannes" last="Nossent">Johannes Nossent</name>
<affiliation>
<nlm:aff id="A10">University Hospital North Norway, Tromso, Norway</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A11">Division of Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lie, Benedicte A" sort="Lie, Benedicte A" uniqKey="Lie B" first="Benedicte A" last="Lie">Benedicte A. Lie</name>
<affiliation>
<nlm:aff id="A12">Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo, Norway</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A13">Department of Immunology, Oslo University Hospital, Oslo, Norway</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="F Rre, Ystein" sort="F Rre, Ystein" uniqKey="F Rre " first=" Ystein" last="F Rre"> Ystein F Rre</name>
<affiliation>
<nlm:aff id="A14">Department of Rheumatology, University Hospital Oslo, Oslo, Norway</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Tuomilehto, Jaakko" sort="Tuomilehto, Jaakko" uniqKey="Tuomilehto J" first="Jaakko" last="Tuomilehto">Jaakko Tuomilehto</name>
<affiliation>
<nlm:aff id="A15">Centre for Vascular Prevention, Danube-University Krems, Krems, Austria</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A16">Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A17">King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Laiho, Kari" sort="Laiho, Kari" uniqKey="Laiho K" first="Kari" last="Laiho">Kari Laiho</name>
<affiliation>
<nlm:aff id="A18">Paijat-Hame Central Hospital, Lahti, Finland</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Jiang, Lei" sort="Jiang, Lei" uniqKey="Jiang L" first="Lei" last="Jiang">Lei Jiang</name>
<affiliation>
<nlm:aff id="A19">Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Liu, Yu" sort="Liu, Yu" uniqKey="Liu Y" first="Yu" last="Liu">Yu Liu</name>
<affiliation>
<nlm:aff id="A19">Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wu, Xin" sort="Wu, Xin" uniqKey="Wu X" first="Xin" last="Wu">Xin Wu</name>
<affiliation>
<nlm:aff id="A19">Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Bradbury, Linda A" sort="Bradbury, Linda A" uniqKey="Bradbury L" first="Linda A" last="Bradbury">Linda A. Bradbury</name>
<affiliation>
<nlm:aff id="A1">University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Elewaut, Dirk" sort="Elewaut, Dirk" uniqKey="Elewaut D" first="Dirk" last="Elewaut">Dirk Elewaut</name>
<affiliation>
<nlm:aff id="A20">Department of Rheumatology, Ghent University Hospital, Ghent, Belgium</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Burgos Vargas, Ruben" sort="Burgos Vargas, Ruben" uniqKey="Burgos Vargas R" first="Ruben" last="Burgos-Vargas">Ruben Burgos-Vargas</name>
<affiliation>
<nlm:aff id="A21">Department of Rheumatology, Hospital General de México, Faculty of Medicine, Universidad Nacional Autónoma de México, Mexico City, México</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Stebbings, Simon" sort="Stebbings, Simon" uniqKey="Stebbings S" first="Simon" last="Stebbings">Simon Stebbings</name>
<affiliation>
<nlm:aff id="A22">Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Appleton, Louise" sort="Appleton, Louise" uniqKey="Appleton L" first="Louise" last="Appleton">Louise Appleton</name>
<affiliation>
<nlm:aff id="A2">National Institute for Health Research (NIHR) Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford, UK</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Farrah, Claire" sort="Farrah, Claire" uniqKey="Farrah C" first="Claire" last="Farrah">Claire Farrah</name>
<affiliation>
<nlm:aff id="A2">National Institute for Health Research (NIHR) Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford, UK</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lau, Jonathan" sort="Lau, Jonathan" uniqKey="Lau J" first="Jonathan" last="Lau">Jonathan Lau</name>
<affiliation>
<nlm:aff id="A2">National Institute for Health Research (NIHR) Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford, UK</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Kenna, Tony J" sort="Kenna, Tony J" uniqKey="Kenna T" first="Tony J" last="Kenna">Tony J. Kenna</name>
<affiliation>
<nlm:aff id="A1">University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Haroon, Nigil" sort="Haroon, Nigil" uniqKey="Haroon N" first="Nigil" last="Haroon">Nigil Haroon</name>
<affiliation>
<nlm:aff id="A23">Division of Rheumatology, Toronto Western Hospital, Toronto, Ontario, Canada</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ferreira, Manuel A" sort="Ferreira, Manuel A" uniqKey="Ferreira M" first="Manuel A" last="Ferreira">Manuel A. Ferreira</name>
<affiliation>
<nlm:aff id="A24">Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Queensland, Australia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Yang, Jian" sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name>
<affiliation>
<nlm:aff id="A1">University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mulero, Juan" sort="Mulero, Juan" uniqKey="Mulero J" first="Juan" last="Mulero">Juan Mulero</name>
<affiliation>
<nlm:aff id="A25">Rheumatology Department, Hospital Puerta de Hierro, Madrid, Spain</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Fernandez Sueiro, Jose Luis" sort="Fernandez Sueiro, Jose Luis" uniqKey="Fernandez Sueiro J" first="Jose Luis" last="Fernandez-Sueiro">Jose Luis Fernandez-Sueiro</name>
<affiliation>
<nlm:aff id="A26">Rheumatology Department, Complejo Hospitalario La Coruña, Instituto de Investigación Biomédica A Coruña (INIBIC), La Coruña, Spain</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gonzalez Gay, Miguel A" sort="Gonzalez Gay, Miguel A" uniqKey="Gonzalez Gay M" first="Miguel A" last="Gonzalez-Gay">Miguel A. Gonzalez-Gay</name>
<affiliation>
<nlm:aff id="A27">Rheumatology Department, Hospital Marqués de Valcecilla, Instituto de Formación e Investigación Marqués de Valcecillas (IFIMAV), Santander, Spain</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lopez Larrea, Carlos" sort="Lopez Larrea, Carlos" uniqKey="Lopez Larrea C" first="Carlos" last="Lopez-Larrea">Carlos Lopez-Larrea</name>
<affiliation>
<nlm:aff id="A28">Department of Immunology, Asturias Central University Hospital, Oviedo, Spain</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A29">Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name>
<affiliation>
<nlm:aff id="A30">Wellcome Trust Sanger Institute, Cambridge, UK</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Donnelly, Peter" sort="Donnelly, Peter" uniqKey="Donnelly P" first="Peter" last="Donnelly">Peter Donnelly</name>
<affiliation>
<nlm:aff id="A31">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Bowness, Paul" sort="Bowness, Paul" uniqKey="Bowness P" first="Paul" last="Bowness">Paul Bowness</name>
<affiliation>
<nlm:aff id="A2">National Institute for Health Research (NIHR) Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford, UK</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gafney, Karl" sort="Gafney, Karl" uniqKey="Gafney K" first="Karl" last="Gafney">Karl Gafney</name>
<affiliation>
<nlm:aff id="A33">Department of Rheumatology, Norfolk and Norwich University Hospital, Norwich, UK</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gaston, Hill" sort="Gaston, Hill" uniqKey="Gaston H" first="Hill" last="Gaston">Hill Gaston</name>
<affiliation>
<nlm:aff id="A34">Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gladman, Dafna D" sort="Gladman, Dafna D" uniqKey="Gladman D" first="Dafna D" last="Gladman">Dafna D. Gladman</name>
<affiliation>
<nlm:aff id="A35">Division of Rheumatology, University of Toronto, Toronto, Ontario, Canada</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A36">Toronto Western Research Institute, Toronto, Ontario, Canada</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A37">Psoriatic Arthritis Program, University Health Network, Toronto, Ontario, Canada</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Rahman, Proton" sort="Rahman, Proton" uniqKey="Rahman P" first="Proton" last="Rahman">Proton Rahman</name>
<affiliation>
<nlm:aff id="A38">Memorial University of Newfoundland, St. John's, Newfoundland, Canada</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Maksymowych, Walter P" sort="Maksymowych, Walter P" uniqKey="Maksymowych W" first="Walter P" last="Maksymowych">Walter P. Maksymowych</name>
<affiliation>
<nlm:aff id="A39">Department of Medicine, University of Alberta, Edmonton, Alberta, Canada</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Xu, Huji" sort="Xu, Huji" uniqKey="Xu H" first="Huji" last="Xu">Huji Xu</name>
<affiliation>
<nlm:aff id="A19">Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Crusius, J Bart A" sort="Crusius, J Bart A" uniqKey="Crusius J" first="J Bart A" last="Crusius">J Bart A. Crusius</name>
<affiliation>
<nlm:aff id="A40">Laboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Der Horst Bruinsma, Irene E" sort="Van Der Horst Bruinsma, Irene E" uniqKey="Van Der Horst Bruinsma I" first="Irene E" last="Van Der Horst-Bruinsma">Irene E. Van Der Horst-Bruinsma</name>
<affiliation>
<nlm:aff id="A41">Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Chou, Chung Tei" sort="Chou, Chung Tei" uniqKey="Chou C" first="Chung-Tei" last="Chou">Chung-Tei Chou</name>
<affiliation>
<nlm:aff id="A42">Department of Medicine, Division of Allergy, Immunology, Rheumatology, Taipei Veterans General Hospital, Taipei, Taiwan</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A43">School of Medicine, National Yang-Ming University, Taipei, Taiwan</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Valle O Ate, Raphael" sort="Valle O Ate, Raphael" uniqKey="Valle O Ate R" first="Raphael" last="Valle-O Ate">Raphael Valle-O Ate</name>
<affiliation>
<nlm:aff id="A44">Spondyloarthropathy Group, Division of Rheumatology, Hospital Militar Central, Universidad de La Sabana, Bogotá, Colombia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Romero Sanchez, Consuelo" sort="Romero Sanchez, Consuelo" uniqKey="Romero Sanchez C" first="Consuelo" last="Romero-Sánchez">Consuelo Romero-Sánchez</name>
<affiliation>
<nlm:aff id="A44">Spondyloarthropathy Group, Division of Rheumatology, Hospital Militar Central, Universidad de La Sabana, Bogotá, Colombia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hansen, Inger Myrnes" sort="Hansen, Inger Myrnes" uniqKey="Hansen I" first="Inger Myrnes" last="Hansen">Inger Myrnes Hansen</name>
<affiliation>
<nlm:aff id="A45">Helgelandssykehuset, Mo i Rana, Norway</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Pimentel Santos, Fernando M" sort="Pimentel Santos, Fernando M" uniqKey="Pimentel Santos F" first="Fernando M" last="Pimentel-Santos">Fernando M. Pimentel-Santos</name>
<affiliation>
<nlm:aff id="A46">Chronic Diseases Research Centre (CEDOC), Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Inman, Robert D" sort="Inman, Robert D" uniqKey="Inman R" first="Robert D" last="Inman">Robert D. Inman</name>
<affiliation>
<nlm:aff id="A23">Division of Rheumatology, Toronto Western Hospital, Toronto, Ontario, Canada</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Videm, Vibeke" sort="Videm, Vibeke" uniqKey="Videm V" first="Vibeke" last="Videm">Vibeke Videm</name>
<affiliation>
<nlm:aff id="A47">Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A48">Department of Immunology and Transfusion Medicine, Trondheim University Hospital, Trondheim, Norway</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Martin, Javier" sort="Martin, Javier" uniqKey="Martin J" first="Javier" last="Martin">Javier Martin</name>
<affiliation>
<nlm:aff id="A49">Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Breban, Maxime" sort="Breban, Maxime" uniqKey="Breban M" first="Maxime" last="Breban">Maxime Breban</name>
<affiliation>
<nlm:aff id="A8">Institut Cochin, Université Paris–Descartes, Centre National de Recherche Scientifique (CNRS) Unité Mixte de Recherhce (UMR) 8104, Institut National de la Santé et de la Recherche Médicale (INSERM) U1016, Paris, France</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A9">Division of Rheumatology, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris, Versailles-Saint-Quentin en Yvelines University, Boulogne-Billancourt, France</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Reveille, John D" sort="Reveille, John D" uniqKey="Reveille J" first="John D" last="Reveille">John D. Reveille</name>
<affiliation>
<nlm:aff id="A7">Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, Texas, USA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M" last="Evans">David M. Evans</name>
<affiliation>
<nlm:aff id="A50">Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Socia and Community Medicine, Bristol, UK</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Kim, Tae Hwan" sort="Kim, Tae Hwan" uniqKey="Kim T" first="Tae-Hwan" last="Kim">Tae-Hwan Kim</name>
<affiliation>
<nlm:aff id="A3">Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wordsworth, Bryan Paul" sort="Wordsworth, Bryan Paul" uniqKey="Wordsworth B" first="Bryan Paul" last="Wordsworth">Bryan Paul Wordsworth</name>
<affiliation>
<nlm:aff id="A2">National Institute for Health Research (NIHR) Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford, UK</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Brown, Matthew A" sort="Brown, Matthew A" uniqKey="Brown M" first="Matthew A" last="Brown">Matthew A. Brown</name>
<affiliation>
<nlm:aff id="A1">University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PMC</idno>
<idno type="pmid">23749187</idno>
<idno type="pmc">3757343</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757343</idno>
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<idno type="doi">10.1038/ng.2667</idno>
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<title xml:lang="en" level="a" type="main">Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci</title>
<author>
<name sortKey="Cortes, Adrian" sort="Cortes, Adrian" uniqKey="Cortes A" first="Adrian" last="Cortes">Adrian Cortes</name>
<affiliation>
<nlm:aff id="A1">University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia</nlm:aff>
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<name sortKey="Hadler, Johanna" sort="Hadler, Johanna" uniqKey="Hadler J" first="Johanna" last="Hadler">Johanna Hadler</name>
<affiliation>
<nlm:aff id="A1">University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia</nlm:aff>
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<affiliation>
<nlm:aff id="A2">National Institute for Health Research (NIHR) Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford, UK</nlm:aff>
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<affiliation>
<nlm:aff id="A1">University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia</nlm:aff>
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<name sortKey="Karaderi, Tugce" sort="Karaderi, Tugce" uniqKey="Karaderi T" first="Tugce" last="Karaderi">Tugce Karaderi</name>
<affiliation>
<nlm:aff id="A2">National Institute for Health Research (NIHR) Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford, UK</nlm:aff>
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<affiliation>
<nlm:aff id="A1">University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia</nlm:aff>
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<affiliation>
<nlm:aff id="A1">University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia</nlm:aff>
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<name sortKey="Pryce, Karena" sort="Pryce, Karena" uniqKey="Pryce K" first="Karena" last="Pryce">Karena Pryce</name>
<affiliation>
<nlm:aff id="A1">University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia</nlm:aff>
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<name sortKey="Harris, Jessica" sort="Harris, Jessica" uniqKey="Harris J" first="Jessica" last="Harris">Jessica Harris</name>
<affiliation>
<nlm:aff id="A1">University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia</nlm:aff>
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<name sortKey="Lee, Seunghun" sort="Lee, Seunghun" uniqKey="Lee S" first="Seunghun" last="Lee">Seunghun Lee</name>
<affiliation>
<nlm:aff id="A3">Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea</nlm:aff>
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<name sortKey="Joo, Kyung Bin" sort="Joo, Kyung Bin" uniqKey="Joo K" first="Kyung Bin" last="Joo">Kyung Bin Joo</name>
<affiliation>
<nlm:aff id="A3">Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Shim, Seung Cheol" sort="Shim, Seung Cheol" uniqKey="Shim S" first="Seung-Cheol" last="Shim">Seung-Cheol Shim</name>
<affiliation>
<nlm:aff id="A4">Department of Medicine, Division of Rheumatology, Eulji University Hospital, Daejeon, Republic of Korea</nlm:aff>
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</author>
<author>
<name sortKey="Weisman, Michael" sort="Weisman, Michael" uniqKey="Weisman M" first="Michael" last="Weisman">Michael Weisman</name>
<affiliation>
<nlm:aff id="A5">Department of Medicine/Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff>
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<name sortKey="Ward, Michael" sort="Ward, Michael" uniqKey="Ward M" first="Michael" last="Ward">Michael Ward</name>
<affiliation>
<nlm:aff id="A6">National Institute of Arthritis and Musculoskeletal and Skin Diseases, US National Institutes of Health, Bethesda, Maryland, USA</nlm:aff>
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<name sortKey="Zhou, Xiaodong" sort="Zhou, Xiaodong" uniqKey="Zhou X" first="Xiaodong" last="Zhou">Xiaodong Zhou</name>
<affiliation>
<nlm:aff id="A7">Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, Texas, USA</nlm:aff>
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</author>
<author>
<name sortKey="Garchon, Henri Jean" sort="Garchon, Henri Jean" uniqKey="Garchon H" first="Henri-Jean" last="Garchon">Henri-Jean Garchon</name>
<affiliation>
<nlm:aff id="A8">Institut Cochin, Université Paris–Descartes, Centre National de Recherche Scientifique (CNRS) Unité Mixte de Recherhce (UMR) 8104, Institut National de la Santé et de la Recherche Médicale (INSERM) U1016, Paris, France</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A9">Division of Rheumatology, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris, Versailles-Saint-Quentin en Yvelines University, Boulogne-Billancourt, France</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Chiocchia, Gilles" sort="Chiocchia, Gilles" uniqKey="Chiocchia G" first="Gilles" last="Chiocchia">Gilles Chiocchia</name>
<affiliation>
<nlm:aff id="A8">Institut Cochin, Université Paris–Descartes, Centre National de Recherche Scientifique (CNRS) Unité Mixte de Recherhce (UMR) 8104, Institut National de la Santé et de la Recherche Médicale (INSERM) U1016, Paris, France</nlm:aff>
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<name sortKey="Nossent, Johannes" sort="Nossent, Johannes" uniqKey="Nossent J" first="Johannes" last="Nossent">Johannes Nossent</name>
<affiliation>
<nlm:aff id="A10">University Hospital North Norway, Tromso, Norway</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A11">Division of Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lie, Benedicte A" sort="Lie, Benedicte A" uniqKey="Lie B" first="Benedicte A" last="Lie">Benedicte A. Lie</name>
<affiliation>
<nlm:aff id="A12">Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo, Norway</nlm:aff>
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<affiliation>
<nlm:aff id="A13">Department of Immunology, Oslo University Hospital, Oslo, Norway</nlm:aff>
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<name sortKey="F Rre, Ystein" sort="F Rre, Ystein" uniqKey="F Rre " first=" Ystein" last="F Rre"> Ystein F Rre</name>
<affiliation>
<nlm:aff id="A14">Department of Rheumatology, University Hospital Oslo, Oslo, Norway</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Tuomilehto, Jaakko" sort="Tuomilehto, Jaakko" uniqKey="Tuomilehto J" first="Jaakko" last="Tuomilehto">Jaakko Tuomilehto</name>
<affiliation>
<nlm:aff id="A15">Centre for Vascular Prevention, Danube-University Krems, Krems, Austria</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A16">Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff>
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<affiliation>
<nlm:aff id="A17">King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff>
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<name sortKey="Laiho, Kari" sort="Laiho, Kari" uniqKey="Laiho K" first="Kari" last="Laiho">Kari Laiho</name>
<affiliation>
<nlm:aff id="A18">Paijat-Hame Central Hospital, Lahti, Finland</nlm:aff>
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<name sortKey="Jiang, Lei" sort="Jiang, Lei" uniqKey="Jiang L" first="Lei" last="Jiang">Lei Jiang</name>
<affiliation>
<nlm:aff id="A19">Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Liu, Yu" sort="Liu, Yu" uniqKey="Liu Y" first="Yu" last="Liu">Yu Liu</name>
<affiliation>
<nlm:aff id="A19">Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wu, Xin" sort="Wu, Xin" uniqKey="Wu X" first="Xin" last="Wu">Xin Wu</name>
<affiliation>
<nlm:aff id="A19">Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China</nlm:aff>
</affiliation>
</author>
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<name sortKey="Bradbury, Linda A" sort="Bradbury, Linda A" uniqKey="Bradbury L" first="Linda A" last="Bradbury">Linda A. Bradbury</name>
<affiliation>
<nlm:aff id="A1">University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Elewaut, Dirk" sort="Elewaut, Dirk" uniqKey="Elewaut D" first="Dirk" last="Elewaut">Dirk Elewaut</name>
<affiliation>
<nlm:aff id="A20">Department of Rheumatology, Ghent University Hospital, Ghent, Belgium</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Burgos Vargas, Ruben" sort="Burgos Vargas, Ruben" uniqKey="Burgos Vargas R" first="Ruben" last="Burgos-Vargas">Ruben Burgos-Vargas</name>
<affiliation>
<nlm:aff id="A21">Department of Rheumatology, Hospital General de México, Faculty of Medicine, Universidad Nacional Autónoma de México, Mexico City, México</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Stebbings, Simon" sort="Stebbings, Simon" uniqKey="Stebbings S" first="Simon" last="Stebbings">Simon Stebbings</name>
<affiliation>
<nlm:aff id="A22">Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Appleton, Louise" sort="Appleton, Louise" uniqKey="Appleton L" first="Louise" last="Appleton">Louise Appleton</name>
<affiliation>
<nlm:aff id="A2">National Institute for Health Research (NIHR) Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford, UK</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Farrah, Claire" sort="Farrah, Claire" uniqKey="Farrah C" first="Claire" last="Farrah">Claire Farrah</name>
<affiliation>
<nlm:aff id="A2">National Institute for Health Research (NIHR) Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford, UK</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lau, Jonathan" sort="Lau, Jonathan" uniqKey="Lau J" first="Jonathan" last="Lau">Jonathan Lau</name>
<affiliation>
<nlm:aff id="A2">National Institute for Health Research (NIHR) Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford, UK</nlm:aff>
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</author>
<author>
<name sortKey="Kenna, Tony J" sort="Kenna, Tony J" uniqKey="Kenna T" first="Tony J" last="Kenna">Tony J. Kenna</name>
<affiliation>
<nlm:aff id="A1">University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Haroon, Nigil" sort="Haroon, Nigil" uniqKey="Haroon N" first="Nigil" last="Haroon">Nigil Haroon</name>
<affiliation>
<nlm:aff id="A23">Division of Rheumatology, Toronto Western Hospital, Toronto, Ontario, Canada</nlm:aff>
</affiliation>
</author>
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<name sortKey="Ferreira, Manuel A" sort="Ferreira, Manuel A" uniqKey="Ferreira M" first="Manuel A" last="Ferreira">Manuel A. Ferreira</name>
<affiliation>
<nlm:aff id="A24">Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Queensland, Australia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Yang, Jian" sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name>
<affiliation>
<nlm:aff id="A1">University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mulero, Juan" sort="Mulero, Juan" uniqKey="Mulero J" first="Juan" last="Mulero">Juan Mulero</name>
<affiliation>
<nlm:aff id="A25">Rheumatology Department, Hospital Puerta de Hierro, Madrid, Spain</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Fernandez Sueiro, Jose Luis" sort="Fernandez Sueiro, Jose Luis" uniqKey="Fernandez Sueiro J" first="Jose Luis" last="Fernandez-Sueiro">Jose Luis Fernandez-Sueiro</name>
<affiliation>
<nlm:aff id="A26">Rheumatology Department, Complejo Hospitalario La Coruña, Instituto de Investigación Biomédica A Coruña (INIBIC), La Coruña, Spain</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gonzalez Gay, Miguel A" sort="Gonzalez Gay, Miguel A" uniqKey="Gonzalez Gay M" first="Miguel A" last="Gonzalez-Gay">Miguel A. Gonzalez-Gay</name>
<affiliation>
<nlm:aff id="A27">Rheumatology Department, Hospital Marqués de Valcecilla, Instituto de Formación e Investigación Marqués de Valcecillas (IFIMAV), Santander, Spain</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lopez Larrea, Carlos" sort="Lopez Larrea, Carlos" uniqKey="Lopez Larrea C" first="Carlos" last="Lopez-Larrea">Carlos Lopez-Larrea</name>
<affiliation>
<nlm:aff id="A28">Department of Immunology, Asturias Central University Hospital, Oviedo, Spain</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A29">Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name>
<affiliation>
<nlm:aff id="A30">Wellcome Trust Sanger Institute, Cambridge, UK</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Donnelly, Peter" sort="Donnelly, Peter" uniqKey="Donnelly P" first="Peter" last="Donnelly">Peter Donnelly</name>
<affiliation>
<nlm:aff id="A31">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Bowness, Paul" sort="Bowness, Paul" uniqKey="Bowness P" first="Paul" last="Bowness">Paul Bowness</name>
<affiliation>
<nlm:aff id="A2">National Institute for Health Research (NIHR) Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford, UK</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gafney, Karl" sort="Gafney, Karl" uniqKey="Gafney K" first="Karl" last="Gafney">Karl Gafney</name>
<affiliation>
<nlm:aff id="A33">Department of Rheumatology, Norfolk and Norwich University Hospital, Norwich, UK</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gaston, Hill" sort="Gaston, Hill" uniqKey="Gaston H" first="Hill" last="Gaston">Hill Gaston</name>
<affiliation>
<nlm:aff id="A34">Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gladman, Dafna D" sort="Gladman, Dafna D" uniqKey="Gladman D" first="Dafna D" last="Gladman">Dafna D. Gladman</name>
<affiliation>
<nlm:aff id="A35">Division of Rheumatology, University of Toronto, Toronto, Ontario, Canada</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A36">Toronto Western Research Institute, Toronto, Ontario, Canada</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A37">Psoriatic Arthritis Program, University Health Network, Toronto, Ontario, Canada</nlm:aff>
</affiliation>
</author>
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<name sortKey="Rahman, Proton" sort="Rahman, Proton" uniqKey="Rahman P" first="Proton" last="Rahman">Proton Rahman</name>
<affiliation>
<nlm:aff id="A38">Memorial University of Newfoundland, St. John's, Newfoundland, Canada</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Maksymowych, Walter P" sort="Maksymowych, Walter P" uniqKey="Maksymowych W" first="Walter P" last="Maksymowych">Walter P. Maksymowych</name>
<affiliation>
<nlm:aff id="A39">Department of Medicine, University of Alberta, Edmonton, Alberta, Canada</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Xu, Huji" sort="Xu, Huji" uniqKey="Xu H" first="Huji" last="Xu">Huji Xu</name>
<affiliation>
<nlm:aff id="A19">Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Crusius, J Bart A" sort="Crusius, J Bart A" uniqKey="Crusius J" first="J Bart A" last="Crusius">J Bart A. Crusius</name>
<affiliation>
<nlm:aff id="A40">Laboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
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<name sortKey="Van Der Horst Bruinsma, Irene E" sort="Van Der Horst Bruinsma, Irene E" uniqKey="Van Der Horst Bruinsma I" first="Irene E" last="Van Der Horst-Bruinsma">Irene E. Van Der Horst-Bruinsma</name>
<affiliation>
<nlm:aff id="A41">Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Chou, Chung Tei" sort="Chou, Chung Tei" uniqKey="Chou C" first="Chung-Tei" last="Chou">Chung-Tei Chou</name>
<affiliation>
<nlm:aff id="A42">Department of Medicine, Division of Allergy, Immunology, Rheumatology, Taipei Veterans General Hospital, Taipei, Taiwan</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A43">School of Medicine, National Yang-Ming University, Taipei, Taiwan</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Valle O Ate, Raphael" sort="Valle O Ate, Raphael" uniqKey="Valle O Ate R" first="Raphael" last="Valle-O Ate">Raphael Valle-O Ate</name>
<affiliation>
<nlm:aff id="A44">Spondyloarthropathy Group, Division of Rheumatology, Hospital Militar Central, Universidad de La Sabana, Bogotá, Colombia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Romero Sanchez, Consuelo" sort="Romero Sanchez, Consuelo" uniqKey="Romero Sanchez C" first="Consuelo" last="Romero-Sánchez">Consuelo Romero-Sánchez</name>
<affiliation>
<nlm:aff id="A44">Spondyloarthropathy Group, Division of Rheumatology, Hospital Militar Central, Universidad de La Sabana, Bogotá, Colombia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hansen, Inger Myrnes" sort="Hansen, Inger Myrnes" uniqKey="Hansen I" first="Inger Myrnes" last="Hansen">Inger Myrnes Hansen</name>
<affiliation>
<nlm:aff id="A45">Helgelandssykehuset, Mo i Rana, Norway</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Pimentel Santos, Fernando M" sort="Pimentel Santos, Fernando M" uniqKey="Pimentel Santos F" first="Fernando M" last="Pimentel-Santos">Fernando M. Pimentel-Santos</name>
<affiliation>
<nlm:aff id="A46">Chronic Diseases Research Centre (CEDOC), Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Inman, Robert D" sort="Inman, Robert D" uniqKey="Inman R" first="Robert D" last="Inman">Robert D. Inman</name>
<affiliation>
<nlm:aff id="A23">Division of Rheumatology, Toronto Western Hospital, Toronto, Ontario, Canada</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Videm, Vibeke" sort="Videm, Vibeke" uniqKey="Videm V" first="Vibeke" last="Videm">Vibeke Videm</name>
<affiliation>
<nlm:aff id="A47">Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A48">Department of Immunology and Transfusion Medicine, Trondheim University Hospital, Trondheim, Norway</nlm:aff>
</affiliation>
</author>
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<name sortKey="Martin, Javier" sort="Martin, Javier" uniqKey="Martin J" first="Javier" last="Martin">Javier Martin</name>
<affiliation>
<nlm:aff id="A49">Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain</nlm:aff>
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</author>
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<name sortKey="Breban, Maxime" sort="Breban, Maxime" uniqKey="Breban M" first="Maxime" last="Breban">Maxime Breban</name>
<affiliation>
<nlm:aff id="A8">Institut Cochin, Université Paris–Descartes, Centre National de Recherche Scientifique (CNRS) Unité Mixte de Recherhce (UMR) 8104, Institut National de la Santé et de la Recherche Médicale (INSERM) U1016, Paris, France</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A9">Division of Rheumatology, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris, Versailles-Saint-Quentin en Yvelines University, Boulogne-Billancourt, France</nlm:aff>
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</author>
<author>
<name sortKey="Reveille, John D" sort="Reveille, John D" uniqKey="Reveille J" first="John D" last="Reveille">John D. Reveille</name>
<affiliation>
<nlm:aff id="A7">Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, Texas, USA</nlm:aff>
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<name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M" last="Evans">David M. Evans</name>
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<nlm:aff id="A50">Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Socia and Community Medicine, Bristol, UK</nlm:aff>
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<name sortKey="Kim, Tae Hwan" sort="Kim, Tae Hwan" uniqKey="Kim T" first="Tae-Hwan" last="Kim">Tae-Hwan Kim</name>
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<nlm:aff id="A3">Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea</nlm:aff>
</affiliation>
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<author>
<name sortKey="Wordsworth, Bryan Paul" sort="Wordsworth, Bryan Paul" uniqKey="Wordsworth B" first="Bryan Paul" last="Wordsworth">Bryan Paul Wordsworth</name>
<affiliation>
<nlm:aff id="A2">National Institute for Health Research (NIHR) Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford, UK</nlm:aff>
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<author>
<name sortKey="Brown, Matthew A" sort="Brown, Matthew A" uniqKey="Brown M" first="Matthew A" last="Brown">Matthew A. Brown</name>
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<nlm:aff id="A1">University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia</nlm:aff>
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</analytic>
<series>
<title level="j">Nature genetics</title>
<idno type="ISSN">1061-4036</idno>
<idno type="eISSN">1546-1718</idno>
<imprint>
<date when="2013">2013</date>
</imprint>
</series>
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</fileDesc>
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<textClass></textClass>
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</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<p id="P1">Ankylosing spondylitis is a common, highly heritable inflammatory arthritis affecting primarily the spine and pelvis. In addition to
<italic>HLA-B*27</italic>
alleles, 12 loci have previously been identified that are associated with ankylosing spondylitis in populations of European ancestry, and 2 associated loci have been identified in Asians. In this study, we used the Illumina Immunochip microarray to perform a case-control association study involving 10,619 individuals with ankylosing spondylitis (cases) and 15,145 controls. We identified 13 new risk loci and 12 additional ankylosing spondylitis–associated haplotypes at 11 loci. Two ankylosing spondylitis–associated regions have now been identified encoding four aminopeptidases that are involved in peptide processing before major histocompatibility complex (MHC) class I presentation. Protective variants at two of these loci are associated both with reduced aminopeptidase function and with MHC class I cell surface expression.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article">
<pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-journal-id">9216904</journal-id>
<journal-id journal-id-type="pubmed-jr-id">2419</journal-id>
<journal-id journal-id-type="nlm-ta">Nat Genet</journal-id>
<journal-id journal-id-type="iso-abbrev">Nat. Genet.</journal-id>
<journal-title-group>
<journal-title>Nature genetics</journal-title>
</journal-title-group>
<issn pub-type="ppub">1061-4036</issn>
<issn pub-type="epub">1546-1718</issn>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">23749187</article-id>
<article-id pub-id-type="pmc">3757343</article-id>
<article-id pub-id-type="doi">10.1038/ng.2667</article-id>
<article-id pub-id-type="manuscript">NIHMS503617</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<collab>International Genetics of Ankylosing Spondylitis Consortium (IGAS)</collab>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Cortes</surname>
<given-names>Adrian</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hadler</surname>
<given-names>Johanna</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Pointon</surname>
<given-names>Jenny P</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Robinson</surname>
<given-names>Philip C</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Karaderi</surname>
<given-names>Tugce</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Leo</surname>
<given-names>Paul</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Cremin</surname>
<given-names>Katie</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Pryce</surname>
<given-names>Karena</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Harris</surname>
<given-names>Jessica</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>lee</surname>
<given-names>Seunghun</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Joo</surname>
<given-names>Kyung Bin</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Shim</surname>
<given-names>Seung-Cheol</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Weisman</surname>
<given-names>Michael</given-names>
</name>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ward</surname>
<given-names>Michael</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Zhou</surname>
<given-names>Xiaodong</given-names>
</name>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Garchon</surname>
<given-names>Henri-Jean</given-names>
</name>
<xref ref-type="aff" rid="A8">8</xref>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chiocchia</surname>
<given-names>Gilles</given-names>
</name>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Nossent</surname>
<given-names>Johannes</given-names>
</name>
<xref ref-type="aff" rid="A10">10</xref>
<xref ref-type="aff" rid="A11">11</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lie</surname>
<given-names>Benedicte A</given-names>
</name>
<xref ref-type="aff" rid="A12">12</xref>
<xref ref-type="aff" rid="A13">13</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Førre</surname>
<given-names>Øystein</given-names>
</name>
<xref ref-type="aff" rid="A14">14</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Tuomilehto</surname>
<given-names>Jaakko</given-names>
</name>
<xref ref-type="aff" rid="A15">15</xref>
<xref ref-type="aff" rid="A16">16</xref>
<xref ref-type="aff" rid="A17">17</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Laiho</surname>
<given-names>Kari</given-names>
</name>
<xref ref-type="aff" rid="A18">18</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Jiang</surname>
<given-names>Lei</given-names>
</name>
<xref ref-type="aff" rid="A19">19</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Liu</surname>
<given-names>Yu</given-names>
</name>
<xref ref-type="aff" rid="A19">19</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Wu</surname>
<given-names>Xin</given-names>
</name>
<xref ref-type="aff" rid="A19">19</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Bradbury</surname>
<given-names>Linda A</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Elewaut</surname>
<given-names>Dirk</given-names>
</name>
<xref ref-type="aff" rid="A20">20</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Burgos-Vargas</surname>
<given-names>Ruben</given-names>
</name>
<xref ref-type="aff" rid="A21">21</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Stebbings</surname>
<given-names>Simon</given-names>
</name>
<xref ref-type="aff" rid="A22">22</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Appleton</surname>
<given-names>Louise</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Farrah</surname>
<given-names>Claire</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lau</surname>
<given-names>Jonathan</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kenna</surname>
<given-names>Tony J</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Haroon</surname>
<given-names>Nigil</given-names>
</name>
<xref ref-type="aff" rid="A23">23</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ferreira</surname>
<given-names>Manuel A</given-names>
</name>
<xref ref-type="aff" rid="A24">24</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Yang</surname>
<given-names>Jian</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Mulero</surname>
<given-names>Juan</given-names>
</name>
<xref ref-type="aff" rid="A25">25</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Fernandez-Sueiro</surname>
<given-names>Jose Luis</given-names>
</name>
<xref ref-type="aff" rid="A26">26</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Gonzalez-Gay</surname>
<given-names>Miguel A</given-names>
</name>
<xref ref-type="aff" rid="A27">27</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>lopez-Larrea</surname>
<given-names>Carlos</given-names>
</name>
<xref ref-type="aff" rid="A28">28</xref>
<xref ref-type="aff" rid="A29">29</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Deloukas</surname>
<given-names>Panos</given-names>
</name>
<xref ref-type="aff" rid="A30">30</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Donnelly</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="A31">31</xref>
</contrib>
<contrib contrib-type="author">
<collab>Australo-Anglo-American Spondyloarthritis Consortium (tASC)</collab>
<xref ref-type="aff" rid="A32">32</xref>
</contrib>
<contrib contrib-type="author">
<collab>Groupe Française d'Etude Génétique des Spondylarthrites (GFeGS)</collab>
<xref ref-type="aff" rid="A32">32</xref>
</contrib>
<contrib contrib-type="author">
<collab>Nord-Trøndelag Health Study (HUNT)</collab>
<xref ref-type="aff" rid="A32">32</xref>
</contrib>
<contrib contrib-type="author">
<collab>Spondyloarthritis Research Consortium of Canada (SPARCC)</collab>
<xref ref-type="aff" rid="A32">32</xref>
</contrib>
<contrib contrib-type="author">
<collab>Wellcome Trust Case Control Consortium 2 (ETCCC2)</collab>
<xref ref-type="aff" rid="A32">32</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Bowness</surname>
<given-names>Paul</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Gafney</surname>
<given-names>Karl</given-names>
</name>
<xref ref-type="aff" rid="A33">33</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Gaston</surname>
<given-names>Hill</given-names>
</name>
<xref ref-type="aff" rid="A34">34</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Gladman</surname>
<given-names>Dafna D</given-names>
</name>
<xref ref-type="aff" rid="A35">35</xref>
<xref ref-type="aff" rid="A36">36</xref>
<xref ref-type="aff" rid="A37">37</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Rahman</surname>
<given-names>Proton</given-names>
</name>
<xref ref-type="aff" rid="A38">38</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Maksymowych</surname>
<given-names>Walter P</given-names>
</name>
<xref ref-type="aff" rid="A39">39</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Xu</surname>
<given-names>Huji</given-names>
</name>
<xref ref-type="aff" rid="A19">19</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Crusius</surname>
<given-names>J Bart A</given-names>
</name>
<xref ref-type="aff" rid="A40">40</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>van der Horst-Bruinsma</surname>
<given-names>Irene E</given-names>
</name>
<xref ref-type="aff" rid="A41">41</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chou</surname>
<given-names>Chung-Tei</given-names>
</name>
<xref ref-type="aff" rid="A42">42</xref>
<xref ref-type="aff" rid="A43">43</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Valle-Oñate</surname>
<given-names>Raphael</given-names>
</name>
<xref ref-type="aff" rid="A44">44</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Romero-Sánchez</surname>
<given-names>Consuelo</given-names>
</name>
<xref ref-type="aff" rid="A44">44</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hansen</surname>
<given-names>Inger Myrnes</given-names>
</name>
<xref ref-type="aff" rid="A45">45</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Pimentel-Santos</surname>
<given-names>Fernando M</given-names>
</name>
<xref ref-type="aff" rid="A46">46</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Inman</surname>
<given-names>Robert D</given-names>
</name>
<xref ref-type="aff" rid="A23">23</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Videm</surname>
<given-names>Vibeke</given-names>
</name>
<xref ref-type="aff" rid="A47">47</xref>
<xref ref-type="aff" rid="A48">48</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Martin</surname>
<given-names>Javier</given-names>
</name>
<xref ref-type="aff" rid="A49">49</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Breban</surname>
<given-names>Maxime</given-names>
</name>
<xref ref-type="aff" rid="A8">8</xref>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Reveille</surname>
<given-names>John D</given-names>
</name>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Evans</surname>
<given-names>David M</given-names>
</name>
<xref ref-type="aff" rid="A50">50</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kim</surname>
<given-names>Tae-Hwan</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Wordsworth</surname>
<given-names>Bryan Paul</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Brown</surname>
<given-names>Matthew A</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
</contrib-group>
<aff id="A1">
<label>1</label>
University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia</aff>
<aff id="A2">
<label>2</label>
National Institute for Health Research (NIHR) Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford, UK</aff>
<aff id="A3">
<label>3</label>
Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea</aff>
<aff id="A4">
<label>4</label>
Department of Medicine, Division of Rheumatology, Eulji University Hospital, Daejeon, Republic of Korea</aff>
<aff id="A5">
<label>5</label>
Department of Medicine/Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California, USA</aff>
<aff id="A6">
<label>6</label>
National Institute of Arthritis and Musculoskeletal and Skin Diseases, US National Institutes of Health, Bethesda, Maryland, USA</aff>
<aff id="A7">
<label>7</label>
Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, Texas, USA</aff>
<aff id="A8">
<label>8</label>
Institut Cochin, Université Paris–Descartes, Centre National de Recherche Scientifique (CNRS) Unité Mixte de Recherhce (UMR) 8104, Institut National de la Santé et de la Recherche Médicale (INSERM) U1016, Paris, France</aff>
<aff id="A9">
<label>9</label>
Division of Rheumatology, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris, Versailles-Saint-Quentin en Yvelines University, Boulogne-Billancourt, France</aff>
<aff id="A10">
<label>10</label>
University Hospital North Norway, Tromso, Norway</aff>
<aff id="A11">
<label>11</label>
Division of Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia</aff>
<aff id="A12">
<label>12</label>
Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo, Norway</aff>
<aff id="A13">
<label>13</label>
Department of Immunology, Oslo University Hospital, Oslo, Norway</aff>
<aff id="A14">
<label>14</label>
Department of Rheumatology, University Hospital Oslo, Oslo, Norway</aff>
<aff id="A15">
<label>15</label>
Centre for Vascular Prevention, Danube-University Krems, Krems, Austria</aff>
<aff id="A16">
<label>16</label>
Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</aff>
<aff id="A17">
<label>17</label>
King Abdulaziz University, Jeddah, Saudi Arabia</aff>
<aff id="A18">
<label>18</label>
Paijat-Hame Central Hospital, Lahti, Finland</aff>
<aff id="A19">
<label>19</label>
Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China</aff>
<aff id="A20">
<label>20</label>
Department of Rheumatology, Ghent University Hospital, Ghent, Belgium</aff>
<aff id="A21">
<label>21</label>
Department of Rheumatology, Hospital General de México, Faculty of Medicine, Universidad Nacional Autónoma de México, Mexico City, México</aff>
<aff id="A22">
<label>22</label>
Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand</aff>
<aff id="A23">
<label>23</label>
Division of Rheumatology, Toronto Western Hospital, Toronto, Ontario, Canada</aff>
<aff id="A24">
<label>24</label>
Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Queensland, Australia</aff>
<aff id="A25">
<label>25</label>
Rheumatology Department, Hospital Puerta de Hierro, Madrid, Spain</aff>
<aff id="A26">
<label>26</label>
Rheumatology Department, Complejo Hospitalario La Coruña, Instituto de Investigación Biomédica A Coruña (INIBIC), La Coruña, Spain</aff>
<aff id="A27">
<label>27</label>
Rheumatology Department, Hospital Marqués de Valcecilla, Instituto de Formación e Investigación Marqués de Valcecillas (IFIMAV), Santander, Spain</aff>
<aff id="A28">
<label>28</label>
Department of Immunology, Asturias Central University Hospital, Oviedo, Spain</aff>
<aff id="A29">
<label>29</label>
Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain</aff>
<aff id="A30">
<label>30</label>
Wellcome Trust Sanger Institute, Cambridge, UK</aff>
<aff id="A31">
<label>31</label>
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</aff>
<aff id="A32">
<label>32</label>
Details appear in the
<xref rid="SD1" ref-type="supplementary-material">supplementary Note</xref>
</aff>
<aff id="A33">
<label>33</label>
Department of Rheumatology, Norfolk and Norwich University Hospital, Norwich, UK</aff>
<aff id="A34">
<label>34</label>
Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK</aff>
<aff id="A35">
<label>35</label>
Division of Rheumatology, University of Toronto, Toronto, Ontario, Canada</aff>
<aff id="A36">
<label>36</label>
Toronto Western Research Institute, Toronto, Ontario, Canada</aff>
<aff id="A37">
<label>37</label>
Psoriatic Arthritis Program, University Health Network, Toronto, Ontario, Canada</aff>
<aff id="A38">
<label>38</label>
Memorial University of Newfoundland, St. John's, Newfoundland, Canada</aff>
<aff id="A39">
<label>39</label>
Department of Medicine, University of Alberta, Edmonton, Alberta, Canada</aff>
<aff id="A40">
<label>40</label>
Laboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands</aff>
<aff id="A41">
<label>41</label>
Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands</aff>
<aff id="A42">
<label>42</label>
Department of Medicine, Division of Allergy, Immunology, Rheumatology, Taipei Veterans General Hospital, Taipei, Taiwan</aff>
<aff id="A43">
<label>43</label>
School of Medicine, National Yang-Ming University, Taipei, Taiwan</aff>
<aff id="A44">
<label>44</label>
Spondyloarthropathy Group, Division of Rheumatology, Hospital Militar Central, Universidad de La Sabana, Bogotá, Colombia</aff>
<aff id="A45">
<label>45</label>
Helgelandssykehuset, Mo i Rana, Norway</aff>
<aff id="A46">
<label>46</label>
Chronic Diseases Research Centre (CEDOC), Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal</aff>
<aff id="A47">
<label>47</label>
Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway</aff>
<aff id="A48">
<label>48</label>
Department of Immunology and Transfusion Medicine, Trondheim University Hospital, Trondheim, Norway</aff>
<aff id="A49">
<label>49</label>
Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain</aff>
<aff id="A50">
<label>50</label>
Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Socia and Community Medicine, Bristol, UK</aff>
<author-notes>
<corresp id="FN1">Correspondence should be addressed to M.A.B. (
<email>matt.brown@uq.edu.au</email>
)</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted">
<day>9</day>
<month>8</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub">
<day>09</day>
<month>6</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="ppub">
<month>7</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>30</day>
<month>8</month>
<year>2013</year>
</pub-date>
<volume>45</volume>
<issue>7</issue>
<fpage>730</fpage>
<lpage>738</lpage>
<permissions>
<copyright-statement>© 2013 Nature America, Inc. All rights reserved.</copyright-statement>
<copyright-year>2013</copyright-year>
</permissions>
<abstract>
<p id="P1">Ankylosing spondylitis is a common, highly heritable inflammatory arthritis affecting primarily the spine and pelvis. In addition to
<italic>HLA-B*27</italic>
alleles, 12 loci have previously been identified that are associated with ankylosing spondylitis in populations of European ancestry, and 2 associated loci have been identified in Asians. In this study, we used the Illumina Immunochip microarray to perform a case-control association study involving 10,619 individuals with ankylosing spondylitis (cases) and 15,145 controls. We identified 13 new risk loci and 12 additional ankylosing spondylitis–associated haplotypes at 11 loci. Two ankylosing spondylitis–associated regions have now been identified encoding four aminopeptidases that are involved in peptide processing before major histocompatibility complex (MHC) class I presentation. Protective variants at two of these loci are associated both with reduced aminopeptidase function and with MHC class I cell surface expression.</p>
</abstract>
<funding-group>
<award-group>
<funding-source country="United States">National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS</funding-source>
<award-id>P01 AR052915 || AR</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>

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