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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders</title><author><name sortKey="Den Hoed, Marcel" sort="Den Hoed, Marcel" uniqKey="Den Hoed M" first="Marcel" last="Den Hoed">Marcel Den Hoed</name><affiliation><nlm:aff id="A1">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Eijgelsheim, Mark" sort="Eijgelsheim, Mark" uniqKey="Eijgelsheim M" first="Mark" last="Eijgelsheim">Mark Eijgelsheim</name><affiliation><nlm:aff id="A3">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation><nlm:aff id="A4">Estonian Biocenter, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Brundel, Bianca J J M" sort="Brundel, Bianca J J M" uniqKey="Brundel B" first="Bianca J J M" last="Brundel">Bianca J J M. Brundel</name><affiliation><nlm:aff id="A7">Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Peal, David S" sort="Peal, David S" uniqKey="Peal D" first="David S" last="Peal">David S. Peal</name><affiliation><nlm:aff id="A8">Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M" last="Evans">David M. Evans</name><affiliation><nlm:aff id="A9">MRC Centre for Causal Analyses in Translational Epidemiology (CAiTE), School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M" last="Nolte">Ilja M. Nolte</name><affiliation><nlm:aff id="A10">Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Segre, Ayellet V" sort="Segre, Ayellet V" uniqKey="Segre A" first="Ayellet V" last="Segrè">Ayellet V. Segrè</name><affiliation><nlm:aff id="A11">Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Holm, Hilma" sort="Holm, Hilma" uniqKey="Holm H" first="Hilma" last="Holm">Hilma Holm</name><affiliation><nlm:aff id="A13">deCODE Genetics, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Handsaker, Robert E" sort="Handsaker, Robert E" uniqKey="Handsaker R" first="Robert E" last="Handsaker">Robert E. Handsaker</name><affiliation><nlm:aff id="A12">Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Westra, Harm Jan" sort="Westra, Harm Jan" uniqKey="Westra H" first="Harm-Jan" last="Westra">Harm-Jan Westra</name><affiliation><nlm:aff id="A15">Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name><affiliation><nlm:aff id="A16">Clinical Pharmacology, National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name><affiliation><nlm:aff id="A3">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Centre for Medical Systems Biology, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Yang, Jian" sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name><affiliation><nlm:aff id="A19">Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Lundby, Alicia" sort="Lundby, Alicia" uniqKey="Lundby A" first="Alicia" last="Lundby">Alicia Lundby</name><affiliation><nlm:aff id="A20">Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A21">The Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="A1">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Kim, Young Jin" sort="Kim, Young Jin" uniqKey="Kim Y" first="Young Jin" last="Kim">Young Jin Kim</name><affiliation><nlm:aff id="A23">Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Daejeon, The Republic of Korea</nlm:aff></affiliation></author><author><name sortKey="Go, Min Jin" sort="Go, Min Jin" uniqKey="Go M" first="Min Jin" last="Go">Min Jin Go</name><affiliation><nlm:aff id="A23">Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Daejeon, The Republic of Korea</nlm:aff></affiliation></author><author><name sortKey="Almgren, Peter" sort="Almgren, Peter" uniqKey="Almgren P" first="Peter" last="Almgren">Peter Almgren</name><affiliation><nlm:aff id="A24">Department of Clinical Sciences, Diabetes and Endocrinology, Lund University and Lund University Diabetes Centre, Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name><affiliation><nlm:aff id="A25">Community Prevention Unit, Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Boucher, Gabrielle" sort="Boucher, Gabrielle" uniqKey="Boucher G" first="Gabrielle" last="Boucher">Gabrielle Boucher</name><affiliation><nlm:aff id="A26">Université de Montréal, Montreal, Quebec, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Montreal Heart Institute, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Cornelis, Marilyn C" sort="Cornelis, Marilyn C" uniqKey="Cornelis M" first="Marilyn C" last="Cornelis">Marilyn C. Cornelis</name><affiliation><nlm:aff id="A28">Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Gudbjartsson, Daniel" sort="Gudbjartsson, Daniel" uniqKey="Gudbjartsson D" first="Daniel" last="Gudbjartsson">Daniel Gudbjartsson</name><affiliation><nlm:aff id="A13">deCODE Genetics, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Hadley, David" sort="Hadley, David" uniqKey="Hadley D" first="David" last="Hadley">David Hadley</name><affiliation><nlm:aff id="A29">Division of Population Health Sciences and Education, St. George’s, University of London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Pediatric Epidemiology Center, University of South Florida, Tampa, Florida, USA</nlm:aff></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation><nlm:aff id="A31">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="A32">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Heijer, Martin Den" sort="Heijer, Martin Den" uniqKey="Heijer M" first="Martin Den" last="Heijer">Martin Den Heijer</name><affiliation><nlm:aff id="A33">Department of Internal Medicine, VU Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Igl, Wilmar" sort="Igl, Wilmar" uniqKey="Igl W" first="Wilmar" last="Igl">Wilmar Igl</name><affiliation><nlm:aff id="A34">Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Jackson, Anne U" sort="Jackson, Anne U" uniqKey="Jackson A" first="Anne U" last="Jackson">Anne U. Jackson</name><affiliation><nlm:aff id="A35">Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name><affiliation><nlm:aff id="A37">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Swiss Institute of Bioinformatics, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Luan, Jian N" sort="Luan, Jian N" uniqKey="Luan J" first="Jian N" last="Luan">Jian N Luan</name><affiliation><nlm:aff id="A1">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Kemp, John P" sort="Kemp, John P" uniqKey="Kemp J" first="John P" last="Kemp">John P. Kemp</name><affiliation><nlm:aff id="A9">MRC Centre for Causal Analyses in Translational Epidemiology (CAiTE), School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Kristiansson, Kati" sort="Kristiansson, Kati" uniqKey="Kristiansson K" first="Kati" last="Kristiansson">Kati Kristiansson</name><affiliation><nlm:aff id="A39">The Institute of Molecular Medicine, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Ladenvall, Claes" sort="Ladenvall, Claes" uniqKey="Ladenvall C" first="Claes" last="Ladenvall">Claes Ladenvall</name><affiliation><nlm:aff id="A24">Department of Clinical Sciences, Diabetes and Endocrinology, Lund University and Lund University Diabetes Centre, Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lorentzon, Mattias" sort="Lorentzon, Mattias" uniqKey="Lorentzon M" first="Mattias" last="Lorentzon">Mattias Lorentzon</name><affiliation><nlm:aff id="A41">Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Montasser, May E" sort="Montasser, May E" uniqKey="Montasser M" first="May E" last="Montasser">May E. Montasser</name><affiliation><nlm:aff id="A42">Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland, School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Njajou, Omer T" sort="Njajou, Omer T" uniqKey="Njajou O" first="Omer T" last="Njajou">Omer T. Njajou</name><affiliation><nlm:aff id="A43">Department of Medicine, Institute for Human Genetics, University of California, San Francisco, San Francisco, California, USA</nlm:aff></affiliation></author><author><name sortKey="O Eilly, Paul F" sort="O Eilly, Paul F" uniqKey="O Eilly P" first="Paul F" last="O Eilly">Paul F. O Eilly</name><affiliation><nlm:aff id="A44">Department of Epidemiology and Biostatistics, Imperial College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A45">MRC–Health Protection Agency (MRC-HPA) Centre for Environment and Health, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Padmanabhan, Sandosh" sort="Padmanabhan, Sandosh" uniqKey="Padmanabhan S" first="Sandosh" last="Padmanabhan">Sandosh Padmanabhan</name><affiliation><nlm:aff id="A46">Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Pourcain, Beate St" sort="Pourcain, Beate St" uniqKey="Pourcain B" first="Beate St." last="Pourcain">Beate St. Pourcain</name><affiliation><nlm:aff id="A9">MRC Centre for Causal Analyses in Translational Epidemiology (CAiTE), School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Rankinen, Tuomo" sort="Rankinen, Tuomo" uniqKey="Rankinen T" first="Tuomo" last="Rankinen">Tuomo Rankinen</name><affiliation><nlm:aff id="A47">Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA</nlm:aff></affiliation></author><author><name sortKey="Salo, Perttu" sort="Salo, Perttu" uniqKey="Salo P" first="Perttu" last="Salo">Perttu Salo</name><affiliation><nlm:aff id="A39">The Institute of Molecular Medicine, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation><nlm:aff id="A49">Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J" last="Timpson">Nicholas J. Timpson</name><affiliation><nlm:aff id="A9">MRC Centre for Causal Analyses in Translational Epidemiology (CAiTE), School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation><nlm:aff id="A32">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Waite, Lindsay" sort="Waite, Lindsay" uniqKey="Waite L" first="Lindsay" last="Waite">Lindsay Waite</name><affiliation><nlm:aff id="A50">HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA</nlm:aff></affiliation></author><author><name sortKey="Wheeler, William" sort="Wheeler, William" uniqKey="Wheeler W" first="William" last="Wheeler">William Wheeler</name><affiliation><nlm:aff id="A51">Information Management Services, Inc., Rockville, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><affiliation><nlm:aff id="A44">Department of Epidemiology and Biostatistics, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Draisma, Harmen H M" sort="Draisma, Harmen H M" uniqKey="Draisma H" first="Harmen H M" last="Draisma">Harmen H M. Draisma</name><affiliation><nlm:aff id="A52">Department of Biological Psychology, VU University Amsterdam and Institute for Health and Care Research (EMGO+), VU Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Feitosa, Mary F" sort="Feitosa, Mary F" uniqKey="Feitosa M" first="Mary F" last="Feitosa">Mary F. Feitosa</name><affiliation><nlm:aff id="A53">Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="Kerr, Kathleen F" sort="Kerr, Kathleen F" uniqKey="Kerr K" first="Kathleen F" last="Kerr">Kathleen F. Kerr</name><affiliation><nlm:aff id="A54">Department of Biostatistics, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Lind, Penelope A" sort="Lind, Penelope A" uniqKey="Lind P" first="Penelope A" last="Lind">Penelope A. Lind</name><affiliation><nlm:aff id="A55">Quantitative Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Mihailov, Evelin" sort="Mihailov, Evelin" uniqKey="Mihailov E" first="Evelin" last="Mihailov">Evelin Mihailov</name><affiliation><nlm:aff id="A4">Estonian Biocenter, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N Charlotte" last="Onland-Moret">N Charlotte Onland-Moret</name><affiliation><nlm:aff id="A56">Complex Genetics Section, Department of Medical Genetics–de Bakker Group, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Song, Ci" sort="Song, Ci" uniqKey="Song C" first="Ci" last="Song">Ci Song</name><affiliation><nlm:aff id="A58">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Weedon, Michael N" sort="Weedon, Michael N" uniqKey="Weedon M" first="Michael N" last="Weedon">Michael N. Weedon</name><affiliation><nlm:aff id="A59">Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff></affiliation></author><author><name sortKey="Xie, Weijia" sort="Xie, Weijia" uniqKey="Xie W" first="Weijia" last="Xie">Weijia Xie</name><affiliation><nlm:aff id="A59">Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff></affiliation></author><author><name sortKey="Yengo, Loic" sort="Yengo, Loic" uniqKey="Yengo L" first="Loic" last="Yengo">Loic Yengo</name><affiliation><nlm:aff id="A60">Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8199, Institut Pasteur de Lille, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Absher, Devin" sort="Absher, Devin" uniqKey="Absher D" first="Devin" last="Absher">Devin Absher</name><affiliation><nlm:aff id="A50">HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA</nlm:aff></affiliation></author><author><name sortKey="Albert, Christine M" sort="Albert, Christine M" uniqKey="Albert C" first="Christine M" last="Albert">Christine M. Albert</name><affiliation><nlm:aff id="A61">Division of Preventive Medicine, Cardiovascular Division, Brigham and Women’s Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Alonso, Alvaro" sort="Alonso, Alvaro" uniqKey="Alonso A" first="Alvaro" last="Alonso">Alvaro Alonso</name><affiliation><nlm:aff id="A63">Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Arking, Dan E" sort="Arking, Dan E" uniqKey="Arking D" first="Dan E" last="Arking">Dan E. Arking</name><affiliation><nlm:aff id="A64">Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A65">McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I W" last="De Bakker">Paul I W. De Bakker</name><affiliation><nlm:aff id="A12">Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Department of Medicine, Division of Genetics, Brigham and Women’s Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Department of Medical Genetics, Division of Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><affiliation><nlm:aff id="A68">Institut National de la Santé et de la Recherche Médicale (INSERM), CESP Centre for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease over The Lifecourse, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A69">UMRS 1018, Université Paris–Sud 11, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Barlassina, Cristina" sort="Barlassina, Cristina" uniqKey="Barlassina C" first="Cristina" last="Barlassina">Cristina Barlassina</name><affiliation><nlm:aff id="A70">Department of Health Sciences, Milan University and Filarete Foundation, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Benaglio, Paola" sort="Benaglio, Paola" uniqKey="Benaglio P" first="Paola" last="Benaglio">Paola Benaglio</name><affiliation><nlm:aff id="A37">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C" last="Bis">Joshua C. Bis</name><affiliation><nlm:aff id="A71">Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Department of Medicine, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name><affiliation><nlm:aff id="A60">Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8199, Institut Pasteur de Lille, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Lille Nord de France University, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A74">INSERM U970, Paris Cardiovascular Research Centre, Hopital Européen Georges Pampidou, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Brage, S Ren" sort="Brage, S Ren" uniqKey="Brage S" first="S Ren" last="Brage">S Ren Brage</name><affiliation><nlm:aff id="A1">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="A75">Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, Maryland, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Chines, Peter S" sort="Chines, Peter S" uniqKey="Chines P" first="Peter S" last="Chines">Peter S. Chines</name><affiliation><nlm:aff id="A77">National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Chung, Mina" sort="Chung, Mina" uniqKey="Chung M" first="Mina" last="Chung">Mina Chung</name><affiliation><nlm:aff id="A78">Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A79">Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA</nlm:aff></affiliation></author><author><name sortKey="Darbar, Dawood" sort="Darbar, Dawood" uniqKey="Darbar D" first="Dawood" last="Darbar">Dawood Darbar</name><affiliation><nlm:aff id="A80">Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA</nlm:aff></affiliation></author><author><name sortKey="Dina, Christian" sort="Dina, Christian" uniqKey="Dina C" first="Christian" last="Dina">Christian Dina</name><affiliation><nlm:aff id="A81">INSERM U1087, CNRS U6291 and University of Nantes, l’Institut du Thorax, Nantes, France</nlm:aff></affiliation><affiliation><nlm:aff id="A82">Centre Hospitalier Universitaire (CHU) Nantes, l’Institut du Thorax, Nantes, France</nlm:aff></affiliation></author><author><name sortKey="Dorr, Marcus" sort="Dorr, Marcus" uniqKey="Dorr M" first="Marcus" last="Dörr">Marcus Dörr</name><affiliation><nlm:aff id="A83">Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A84">DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation><nlm:aff id="A44">Department of Epidemiology and Biostatistics, Imperial College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A45">MRC–Health Protection Agency (MRC-HPA) Centre for Environment and Health, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Felix, Stephan B" sort="Felix, Stephan B" uniqKey="Felix S" first="Stephan B" last="Felix">Stephan B. Felix</name><affiliation><nlm:aff id="A83">Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A84">DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Fuchsberger, Christian" sort="Fuchsberger, Christian" uniqKey="Fuchsberger C" first="Christian" last="Fuchsberger">Christian Fuchsberger</name><affiliation><nlm:aff id="A35">Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J C" last="De Geus">Eco J C. De Geus</name><affiliation><nlm:aff id="A52">Department of Biological Psychology, VU University Amsterdam and Institute for Health and Care Research (EMGO+), VU Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Goyette, Philippe" sort="Goyette, Philippe" uniqKey="Goyette P" first="Philippe" last="Goyette">Philippe Goyette</name><affiliation><nlm:aff id="A26">Université de Montréal, Montreal, Quebec, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Montreal Heart Institute, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="A85">Icelandic Heart Association Research Institute, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A86">University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="A87">Laboratory for Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation><nlm:aff id="A88">Department of Clinical Sciences, Obstetrics and Gynecology, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Havulinna, Aki S" sort="Havulinna, Aki S" uniqKey="Havulinna A" first="Aki S" last="Havulinna">Aki S. Havulinna</name><affiliation><nlm:aff id="A48">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Heckbert, Susan R" sort="Heckbert, Susan R" uniqKey="Heckbert S" first="Susan R" last="Heckbert">Susan R. Heckbert</name><affiliation><nlm:aff id="A71">Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A89">Department of Epidemiology, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A" last="Hicks">Andrew A. Hicks</name><affiliation><nlm:aff id="A90">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck)</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A3">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Ageing, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Holewijn, Suzanne" sort="Holewijn, Suzanne" uniqKey="Holewijn S" first="Suzanne" last="Holewijn">Suzanne Holewijn</name><affiliation><nlm:aff id="A92">Department of General Internal Medicine, Division of Vascular Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hoogstra Berends, Femke" sort="Hoogstra Berends, Femke" uniqKey="Hoogstra Berends F" first="Femke" last="Hoogstra-Berends">Femke Hoogstra-Berends</name><affiliation><nlm:aff id="A7">Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A93">Nyken, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation><nlm:aff id="A52">Department of Biological Psychology, VU University Amsterdam and Institute for Health and Care Research (EMGO+), VU Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Jensen, Majken K" sort="Jensen, Majken K" uniqKey="Jensen M" first="Majken K" last="Jensen">Majken K. Jensen</name><affiliation><nlm:aff id="A28">Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation><nlm:aff id="A34">Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A94">Uppsala Clinical Research Center, Uppsala University Hospital, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Junttila, Juhani" sort="Junttila, Juhani" uniqKey="Junttila J" first="Juhani" last="Junttila">Juhani Junttila</name><affiliation><nlm:aff id="A95">Division of Cardiology, Miller School of Medicine, University of Miami, Miami, Florida, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A96">Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="K B, Stefan" sort="K B, Stefan" uniqKey="K B S" first="Stefan" last="K B">Stefan K B</name><affiliation><nlm:aff id="A97">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians- Universität, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A98">Munich Heart Alliance, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Kanon, Bart" sort="Kanon, Bart" uniqKey="Kanon B" first="Bart" last="Kanon">Bart Kanon</name><affiliation><nlm:aff id="A99">Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Ketkar, Shamika" sort="Ketkar, Shamika" uniqKey="Ketkar S" first="Shamika" last="Ketkar">Shamika Ketkar</name><affiliation><nlm:aff id="A53">Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:aff id="A100">Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Knowles, Joshua W" sort="Knowles, Joshua W" uniqKey="Knowles J" first="Joshua W" last="Knowles">Joshua W. Knowles</name><affiliation><nlm:aff id="A101">Department of Medicine, Stanford University School of Medicine, Stanford, California, USA</nlm:aff></affiliation></author><author><name sortKey="Kooner, Angrad S" sort="Kooner, Angrad S" uniqKey="Kooner A" first="Angrad S" last="Kooner">Angrad S. Kooner</name><affiliation><nlm:aff id="A102">Cardiology Department, Ealing Hospital National Health Service (NHS) Trust, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kors, Jan A" sort="Kors, Jan A" uniqKey="Kors J" first="Jan A" last="Kors">Jan A. Kors</name><affiliation><nlm:aff id="A103">Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name><affiliation><nlm:aff id="A104">Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Milani, Lili" sort="Milani, Lili" uniqKey="Milani L" first="Lili" last="Milani">Lili Milani</name><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Laiho, P Ivi" sort="Laiho, P Ivi" uniqKey="Laiho P" first="P Ivi" last="Laiho">P Ivi Laiho</name><affiliation><nlm:aff id="A105">National Public Health Institute, Biomedicum Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Lakatta, Edward G" sort="Lakatta, Edward G" uniqKey="Lakatta E" first="Edward G" last="Lakatta">Edward G. Lakatta</name><affiliation><nlm:aff id="A106">Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation><nlm:aff id="A1">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Leusink, Maarten" sort="Leusink, Maarten" uniqKey="Leusink M" first="Maarten" last="Leusink">Maarten Leusink</name><affiliation><nlm:aff id="A57">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A107">Division Pharmacoepidemiology & Clinical Pharmacology, Utrecht University, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation><nlm:aff id="A108">Department of Epidemiology & Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina, USA</nlm:aff></affiliation></author><author><name sortKey="Luben, Robert N" sort="Luben, Robert N" uniqKey="Luben R" first="Robert N" last="Luben">Robert N. Luben</name><affiliation><nlm:aff id="A100">Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Lunetta, Kathryn L" sort="Lunetta, Kathryn L" uniqKey="Lunetta K" first="Kathryn L" last="Lunetta">Kathryn L. Lunetta</name><affiliation><nlm:aff id="A109">Department of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A110">National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Lynch, Stacey N" sort="Lynch, Stacey N" uniqKey="Lynch S" first="Stacey N" last="Lynch">Stacey N. Lynch</name><affiliation><nlm:aff id="A8">Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Markus, Marcello R P" sort="Markus, Marcello R P" uniqKey="Markus M" first="Marcello R P" last="Markus">Marcello R P. Markus</name><affiliation><nlm:aff id="A111">Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Marques Vidal, Pedro" sort="Marques Vidal, Pedro" uniqKey="Marques Vidal P" first="Pedro" last="Marques-Vidal">Pedro Marques-Vidal</name><affiliation><nlm:aff id="A112">Institut Universitaire de Médecine Sociale et Préventive (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Leach, Irene Mateo" sort="Leach, Irene Mateo" uniqKey="Leach I" first="Irene Mateo" last="Leach">Irene Mateo Leach</name><affiliation><nlm:aff id="A31">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L" last="Mcardle">Wendy L. Mcardle</name><affiliation><nlm:aff id="A113">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Mccarroll, Steven A" sort="Mccarroll, Steven A" uniqKey="Mccarroll S" first="Steven A" last="Mccarroll">Steven A. Mccarroll</name><affiliation><nlm:aff id="A12">Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E" last="Medland">Sarah E. Medland</name><affiliation><nlm:aff id="A20">Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Quantitative Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Miller, Kathryn A" sort="Miller, Kathryn A" uniqKey="Miller K" first="Kathryn A" last="Miller">Kathryn A. Miller</name><affiliation><nlm:aff id="A44">Department of Epidemiology and Biostatistics, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W" last="Montgomery">Grant W. Montgomery</name><affiliation><nlm:aff id="A114">Molecular Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Morrison, Alanna C" sort="Morrison, Alanna C" uniqKey="Morrison A" first="Alanna C" last="Morrison">Alanna C. Morrison</name><affiliation><nlm:aff id="A115">Human Genetics Center, University of Texas Health Science Center, Houston, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name><affiliation><nlm:aff id="A97">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians- Universität, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A116">Chair of Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A117">Institute of Genetic Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Navarro, Pau" sort="Navarro, Pau" uniqKey="Navarro P" first="Pau" last="Navarro">Pau Navarro</name><affiliation><nlm:aff id="A32">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Nelis, Mari" sort="Nelis, Mari" uniqKey="Nelis M" first="Mari" last="Nelis">Mari Nelis</name><affiliation><nlm:aff id="A4">Estonian Biocenter, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A118">Department of Medical Genetics and Development, University of Geneva Medical School, Geneva, Switzerland</nlm:aff></affiliation></author><author><name sortKey="O Onnell, Jeffrey R" sort="O Onnell, Jeffrey R" uniqKey="O Onnell J" first="Jeffrey R" last="O Onnell">Jeffrey R. O Onnell</name><affiliation><nlm:aff id="A42">Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland, School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="O Onnell, Christopher J" sort="O Onnell, Christopher J" uniqKey="O Onnell C" first="Christopher J" last="O Onnell">Christopher J. O Onnell</name><affiliation><nlm:aff id="A110">National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A119">Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A120">National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Ong, Ken K" sort="Ong, Ken K" uniqKey="Ong K" first="Ken K" last="Ong">Ken K. Ong</name><affiliation><nlm:aff id="A1">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A121">MRC Unit for Lifelong Health and Ageing, London, UK</nlm:aff></affiliation></author><author><name sortKey="Newman, Anne B" sort="Newman, Anne B" uniqKey="Newman A" first="Anne B" last="Newman">Anne B. Newman</name><affiliation><nlm:aff id="A122">Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name><affiliation><nlm:aff id="A98">Munich Heart Alliance, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A123">Institute of Epidemiology II, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation><nlm:aff id="A124">Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation><nlm:aff id="A88">Department of Clinical Sciences, Obstetrics and Gynecology, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A125">National Institute for Health and Welfare, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P" last="Pramstaller">Peter P. Pramstaller</name><affiliation><nlm:aff id="A90">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck)</nlm:aff></affiliation><affiliation><nlm:aff id="A126">Department of Neurology, General Central Hospital, Bolzano, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A127">Department of Neurology, University of Lübeck, Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name><affiliation><nlm:aff id="A71">Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Department of Medicine, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A89">Department of Epidemiology, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A128">Group Health Research Institute, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A129">Department of Health Services, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Rao, Dabeeru C" sort="Rao, Dabeeru C" uniqKey="Rao D" first="Dabeeru C" last="Rao">Dabeeru C. Rao</name><affiliation><nlm:aff id="A130">Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M" last="Ring">Susan M. Ring</name><affiliation><nlm:aff id="A113">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Rossin, Elizabeth J" sort="Rossin, Elizabeth J" uniqKey="Rossin E" first="Elizabeth J" last="Rossin">Elizabeth J. Rossin</name><affiliation><nlm:aff id="A20">Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A131">Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A132">Harvard Biological and Biomedical Sciences Program, Harvard University, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A133">Health Science and Technology M.D. Program, Harvard University and Massachusetts Institute of Technology, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Rudan, Diana" sort="Rudan, Diana" uniqKey="Rudan D" first="Diana" last="Rudan">Diana Rudan</name><affiliation><nlm:aff id="A134">Department of Pathophysiology, Faculty of Medicine, University of Split, Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation><nlm:aff id="A135">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy</nlm:aff></affiliation></author><author><name sortKey="Scott, Robert A" sort="Scott, Robert A" uniqKey="Scott R" first="Robert A" last="Scott">Robert A. Scott</name><affiliation><nlm:aff id="A1">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Sehmi, Jaban S" sort="Sehmi, Jaban S" uniqKey="Sehmi J" first="Jaban S" last="Sehmi">Jaban S. Sehmi</name><affiliation><nlm:aff id="A102">Cardiology Department, Ealing Hospital National Health Service (NHS) Trust, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A136">National Heart and Lung Institute, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Sharp, Stephen" sort="Sharp, Stephen" uniqKey="Sharp S" first="Stephen" last="Sharp">Stephen Sharp</name><affiliation><nlm:aff id="A1">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Shin, Jordan T" sort="Shin, Jordan T" uniqKey="Shin J" first="Jordan T" last="Shin">Jordan T. Shin</name><affiliation><nlm:aff id="A8">Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Singleton, Andrew B" sort="Singleton, Andrew B" uniqKey="Singleton A" first="Andrew B" last="Singleton">Andrew B. Singleton</name><affiliation><nlm:aff id="A137">Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V" last="Smith">Albert V. Smith</name><affiliation><nlm:aff id="A85">Icelandic Heart Association Research Institute, Kopavogur, Iceland</nlm:aff></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation><nlm:aff id="A19">Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A138">Department of Twin Research and Genetic Epidemiology Unit, St. Thomas’ Campus, King’s College London, St. Thomas’ Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D" last="Spector">Tim D. Spector</name><affiliation><nlm:aff id="A138">Department of Twin Research and Genetic Epidemiology Unit, St. Thomas’ Campus, King’s College London, St. Thomas’ Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Stewart, Chip" sort="Stewart, Chip" uniqKey="Stewart C" first="Chip" last="Stewart">Chip Stewart</name><affiliation><nlm:aff id="A20">Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A139">Biology Department, Boston College, Chestnut Hill, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Stringham, Heather M" sort="Stringham, Heather M" uniqKey="Stringham H" first="Heather M" last="Stringham">Heather M. Stringham</name><affiliation><nlm:aff id="A35">Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Tarasov, Kirill V" sort="Tarasov, Kirill V" uniqKey="Tarasov K" first="Kirill V" last="Tarasov">Kirill V. Tarasov</name><affiliation><nlm:aff id="A106">Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G" last="Uitterlinden">André G. Uitterlinden</name><affiliation><nlm:aff id="A3">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Ageing, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A140">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Vandenput, Liesbeth" sort="Vandenput, Liesbeth" uniqKey="Vandenput L" first="Liesbeth" last="Vandenput">Liesbeth Vandenput</name><affiliation><nlm:aff id="A41">Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name><affiliation><nlm:aff id="A110">National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B" last="Whitfield">John B. Whitfield</name><affiliation><nlm:aff id="A141">genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Wijmenga, Cisca" sort="Wijmenga, Cisca" uniqKey="Wijmenga C" first="Cisca" last="Wijmenga">Cisca Wijmenga</name><affiliation><nlm:aff id="A15">Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H" last="Wild">Sarah H. Wild</name><affiliation><nlm:aff id="A142">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation><nlm:aff id="A52">Department of Biological Psychology, VU University Amsterdam and Institute for Health and Care Research (EMGO+), VU Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="A142">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Witteman, Jacqueline C M" sort="Witteman, Jacqueline C M" uniqKey="Witteman J" first="Jacqueline C M" last="Witteman">Jacqueline C M. Witteman</name><affiliation><nlm:aff id="A3">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Ageing, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wong, Andrew" sort="Wong, Andrew" uniqKey="Wong A" first="Andrew" last="Wong">Andrew Wong</name><affiliation><nlm:aff id="A121">MRC Unit for Lifelong Health and Ageing, London, UK</nlm:aff></affiliation></author><author><name sortKey="Wong, Quenna" sort="Wong, Quenna" uniqKey="Wong Q" first="Quenna" last="Wong">Quenna Wong</name><affiliation><nlm:aff id="A54">Department of Biostatistics, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Jamshidi, Yalda" sort="Jamshidi, Yalda" uniqKey="Jamshidi Y" first="Yalda" last="Jamshidi">Yalda Jamshidi</name><affiliation><nlm:aff id="A138">Department of Twin Research and Genetic Epidemiology Unit, St. Thomas’ Campus, King’s College London, St. Thomas’ Hospital, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A143">Division of Biomedical Sciences, St. George’s University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Zitting, Paavo" sort="Zitting, Paavo" uniqKey="Zitting P" first="Paavo" last="Zitting">Paavo Zitting</name><affiliation><nlm:aff id="A144">Department of Physiatrics, Lapland Central Hospital, Rovaniemi, Finland</nlm:aff></affiliation></author><author><name sortKey="Boer, Jolanda M A" sort="Boer, Jolanda M A" uniqKey="Boer J" first="Jolanda M A" last="Boer">Jolanda M A. Boer</name><affiliation><nlm:aff id="A145">Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I" last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:aff id="A52">Department of Biological Psychology, VU University Amsterdam and Institute for Health and Care Research (EMGO+), VU Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Borecki, Ingrid B" sort="Borecki, Ingrid B" uniqKey="Borecki I" first="Ingrid B" last="Borecki">Ingrid B. Borecki</name><affiliation><nlm:aff id="A53">Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A3">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Centre for Medical Systems Biology, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Ekelund, Ulf" sort="Ekelund, Ulf" uniqKey="Ekelund U" first="Ulf" last="Ekelund">Ulf Ekelund</name><affiliation><nlm:aff id="A1">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A146">Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Forouhi, Nita G" sort="Forouhi, Nita G" uniqKey="Forouhi N" first="Nita G" last="Forouhi">Nita G. Forouhi</name><affiliation><nlm:aff id="A1">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="A60">Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8199, Institut Pasteur de Lille, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Lille Nord de France University, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A147">Genomic Medicine, Hammersmith Hospital, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Hingorani, Aroon" sort="Hingorani, Aroon" uniqKey="Hingorani A" first="Aroon" last="Hingorani">Aroon Hingorani</name><affiliation><nlm:aff id="A104">Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation><nlm:aff id="A2">Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A58">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A148">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name><affiliation><nlm:aff id="A104">Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kronmal, Richard A" sort="Kronmal, Richard A" uniqKey="Kronmal R" first="Richard A" last="Kronmal">Richard A. Kronmal</name><affiliation><nlm:aff id="A54">Department of Biostatistics, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Kuh, Diana" sort="Kuh, Diana" uniqKey="Kuh D" first="Diana" last="Kuh">Diana Kuh</name><affiliation><nlm:aff id="A121">MRC Unit for Lifelong Health and Ageing, London, UK</nlm:aff></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation><nlm:aff id="A149">Department of Medical Sciences, Uppsala University, Akademiska Sjukhuset, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="A141">genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A" last="Oostra">Ben A. Oostra</name><affiliation><nlm:aff id="A150">Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L" last="Pedersen">Nancy L. Pedersen</name><affiliation><nlm:aff id="A58">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Quertermous, Thomas" sort="Quertermous, Thomas" uniqKey="Quertermous T" first="Thomas" last="Quertermous">Thomas Quertermous</name><affiliation><nlm:aff id="A101">Department of Medicine, Stanford University School of Medicine, Stanford, California, USA</nlm:aff></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I" last="Rotter">Jerome I. Rotter</name><affiliation><nlm:aff id="A151">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Van Der Schouw, Yvonne T" sort="Van Der Schouw, Yvonne T" uniqKey="Van Der Schouw Y" first="Yvonne T" last="Van Der Schouw">Yvonne T. Van Der Schouw</name><affiliation><nlm:aff id="A57">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Verschuren, W M Monique" sort="Verschuren, W M Monique" uniqKey="Verschuren W" first="W M Monique" last="Verschuren">W M Monique Verschuren</name><affiliation><nlm:aff id="A145">Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Walker, Mark" sort="Walker, Mark" uniqKey="Walker M" first="Mark" last="Walker">Mark Walker</name><affiliation><nlm:aff id="A152">Institue of Cellular Medicine, Newcastle University, Newcastle, UK</nlm:aff></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation><nlm:aff id="A75">Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Arnar, David O" sort="Arnar, David O" uniqKey="Arnar D" first="David O" last="Arnar">David O. Arnar</name><affiliation><nlm:aff id="A153">Department of Medicine, Landspitali University Hospital, Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A154">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Assimes, Themistocles L" sort="Assimes, Themistocles L" uniqKey="Assimes T" first="Themistocles L" last="Assimes">Themistocles L. Assimes</name><affiliation><nlm:aff id="A101">Department of Medicine, Stanford University School of Medicine, Stanford, California, USA</nlm:aff></affiliation></author><author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name><affiliation><nlm:aff id="A155">Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Boehnke, Michael" sort="Boehnke, Michael" uniqKey="Boehnke M" first="Michael" last="Boehnke">Michael Boehnke</name><affiliation><nlm:aff id="A35">Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="De Boer, Rudolf A" sort="De Boer, Rudolf A" uniqKey="De Boer R" first="Rudolf A" last="De Boer">Rudolf A. De Boer</name><affiliation><nlm:aff id="A31">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Bouchard, Claude" sort="Bouchard, Claude" uniqKey="Bouchard C" first="Claude" last="Bouchard">Claude Bouchard</name><affiliation><nlm:aff id="A47">Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA</nlm:aff></affiliation></author><author><name sortKey="Caulfield, W L Mark" sort="Caulfield, W L Mark" uniqKey="Caulfield W" first="W L Mark" last="Caulfield">W L Mark Caulfield</name><affiliation><nlm:aff id="A16">Clinical Pharmacology, National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Chambers, John C" sort="Chambers, John C" uniqKey="Chambers J" first="John C" last="Chambers">John C. Chambers</name><affiliation><nlm:aff id="A44">Department of Epidemiology and Biostatistics, Imperial College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A102">Cardiology Department, Ealing Hospital National Health Service (NHS) Trust, London, UK</nlm:aff></affiliation></author><author><name sortKey="Curhan, Gary" sort="Curhan, Gary" uniqKey="Curhan G" first="Gary" last="Curhan">Gary Curhan</name><affiliation><nlm:aff id="A156">Channing Laboratory and Renal Division, Brigham and Women’s Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A157">Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Cusi, Daniele" sort="Cusi, Daniele" uniqKey="Cusi D" first="Daniele" last="Cusi">Daniele Cusi</name><affiliation><nlm:aff id="A70">Department of Health Sciences, Milan University and Filarete Foundation, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Johan" sort="Eriksson, Johan" uniqKey="Eriksson J" first="Johan" last="Eriksson">Johan Eriksson</name><affiliation><nlm:aff id="A48">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A158">Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A159">Folkhälsan Research Centre, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A160">Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation><nlm:aff id="A49">Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Van Gilst, Wiek H" sort="Van Gilst, Wiek H" uniqKey="Van Gilst W" first="Wiek H" last="Van Gilst">Wiek H. Van Gilst</name><affiliation><nlm:aff id="A31">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Glorioso, Nicola" sort="Glorioso, Nicola" uniqKey="Glorioso N" first="Nicola" last="Glorioso">Nicola Glorioso</name><affiliation><nlm:aff id="A161">Hypertension and Related Diseases Centre–Azienda Ospedaliero Universitaria (AOU), University of Sassari, Sassari, Italy</nlm:aff></affiliation></author><author><name sortKey="De Graaf, Jacqueline" sort="De Graaf, Jacqueline" uniqKey="De Graaf J" first="Jacqueline" last="De Graaf">Jacqueline De Graaf</name><affiliation><nlm:aff id="A92">Department of General Internal Medicine, Division of Vascular Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Groop, Leif" sort="Groop, Leif" uniqKey="Groop L" first="Leif" last="Groop">Leif Groop</name><affiliation><nlm:aff id="A24">Department of Clinical Sciences, Diabetes and Endocrinology, Lund University and Lund University Diabetes Centre, Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation><nlm:aff id="A34">Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hsueh, Wen Chi" sort="Hsueh, Wen Chi" uniqKey="Hsueh W" first="Wen-Chi" last="Hsueh">Wen-Chi Hsueh</name><affiliation><nlm:aff id="A43">Department of Medicine, Institute for Human Genetics, University of California, San Francisco, San Francisco, California, USA</nlm:aff></affiliation></author><author><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B" last="Hu">Frank B. Hu</name><affiliation><nlm:aff id="A28">Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Huikuri, Heikki V" sort="Huikuri, Heikki V" uniqKey="Huikuri H" first="Heikki V" last="Huikuri">Heikki V. Huikuri</name><affiliation><nlm:aff id="A96">Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="A162">Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Iribarren, Carlos" sort="Iribarren, Carlos" uniqKey="Iribarren C" first="Carlos" last="Iribarren">Carlos Iribarren</name><affiliation><nlm:aff id="A163">Division of Research, Kaiser Permanente of Northern California, Oakland, California, USA</nlm:aff></affiliation></author><author><name sortKey="Isomaa, Bo" sort="Isomaa, Bo" uniqKey="Isomaa B" first="Bo" last="Isomaa">Bo Isomaa</name><affiliation><nlm:aff id="A159">Folkhälsan Research Centre, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A164">Department of Social Services and Health Care, Jakobstad, Finland</nlm:aff></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation><nlm:aff id="A44">Department of Epidemiology and Biostatistics, Imperial College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A45">MRC–Health Protection Agency (MRC-HPA) Centre for Environment and Health, Imperial College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A125">National Institute for Health and Welfare, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A165">Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A166">Institute of Health Sciences, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Jula, Antti" sort="Jula, Antti" uniqKey="Jula A" first="Antti" last="Jula">Antti Jula</name><affiliation><nlm:aff id="A167">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:aff id="A168">Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Kiemeney, Lambertus A" sort="Kiemeney, Lambertus A" uniqKey="Kiemeney L" first="Lambertus A" last="Kiemeney">Lambertus A. Kiemeney</name><affiliation><nlm:aff id="A169">Department for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A170">Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Der Klauw, Melanie M" sort="Van Der Klauw, Melanie M" uniqKey="Van Der Klauw M" first="Melanie M" last="Van Der Klauw">Melanie M. Van Der Klauw</name><affiliation><nlm:aff id="A171">Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S" last="Kooner">Jaspal S. Kooner</name><affiliation><nlm:aff id="A102">Cardiology Department, Ealing Hospital National Health Service (NHS) Trust, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A136">National Heart and Lung Institute, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="A162">Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Iacoviello, Licia" sort="Iacoviello, Licia" uniqKey="Iacoviello L" first="Licia" last="Iacoviello">Licia Iacoviello</name><affiliation><nlm:aff id="A172">Laboratory of Genetic and Environmental Epidemiology, Fondazione di Ricerca e Cura Giovanni Paolo II, Catholic University, Campobasso, Italy</nlm:aff></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:aff id="A168">Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Lokki, Marja Liisa L" sort="Lokki, Marja Liisa L" uniqKey="Lokki M" first="Marja-Liisa L" last="Lokki">Marja-Liisa L. Lokki</name><affiliation><nlm:aff id="A173">transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D" last="Mitchell">Braxton D. Mitchell</name><affiliation><nlm:aff id="A42">Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland, School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name><affiliation><nlm:aff id="A174">Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Nieminen, Markku S" sort="Nieminen, Markku S" uniqKey="Nieminen M" first="Markku S" last="Nieminen">Markku S. Nieminen</name><affiliation><nlm:aff id="A175">Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Ohlsson, Claes" sort="Ohlsson, Claes" uniqKey="Ohlsson C" first="Claes" last="Ohlsson">Claes Ohlsson</name><affiliation><nlm:aff id="A41">Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Poulter, Neil R" sort="Poulter, Neil R" uniqKey="Poulter N" first="Neil R" last="Poulter">Neil R. Poulter</name><affiliation><nlm:aff id="A176">International Centre for Circulatory Health (ICCH), Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Qi, Lu" sort="Qi, Lu" uniqKey="Qi L" first="Lu" last="Qi">Lu Qi</name><affiliation><nlm:aff id="A28">Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Raitakari, Olli T" sort="Raitakari, Olli T" uniqKey="Raitakari O" first="Olli T" last="Raitakari">Olli T. Raitakari</name><affiliation><nlm:aff id="A177">Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A178">Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Rimm, Eric B" sort="Rimm, Eric B" uniqKey="Rimm E" first="Eric B" last="Rimm">Eric B. Rimm</name><affiliation><nlm:aff id="A28">Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Rioux, John D" sort="Rioux, John D" uniqKey="Rioux J" first="John D" last="Rioux">John D. Rioux</name><affiliation><nlm:aff id="A26">Université de Montréal, Montreal, Quebec, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Montreal Heart Institute, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Rizzi, Federica" sort="Rizzi, Federica" uniqKey="Rizzi F" first="Federica" last="Rizzi">Federica Rizzi</name><affiliation><nlm:aff id="A179">Kos Genetic, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="A142">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation><nlm:aff id="A48">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Sever, Peter S" sort="Sever, Peter S" uniqKey="Sever P" first="Peter S" last="Sever">Peter S. Sever</name><affiliation><nlm:aff id="A176">International Centre for Circulatory Health (ICCH), Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Shields, Denis C" sort="Shields, Denis C" uniqKey="Shields D" first="Denis C" last="Shields">Denis C. Shields</name><affiliation><nlm:aff id="A180">Complex and Adaptive Systems Laboratory, University College Dublin, Belfield, Dublin, Ireland</nlm:aff></affiliation><affiliation><nlm:aff id="A181">Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland</nlm:aff></affiliation><affiliation><nlm:aff id="A182">School of Medicine and Medical Sciences, University College Dublin, Belfield, Dublin, Ireland</nlm:aff></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R" last="Shuldiner">Alan R. Shuldiner</name><affiliation><nlm:aff id="A42">Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland, School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A183">Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Sinisalo, Juha" sort="Sinisalo, Juha" uniqKey="Sinisalo J" first="Juha" last="Sinisalo">Juha Sinisalo</name><affiliation><nlm:aff id="A175">Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Stanton, Alice V" sort="Stanton, Alice V" uniqKey="Stanton A" first="Alice V" last="Stanton">Alice V. Stanton</name><affiliation><nlm:aff id="A184">Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland</nlm:aff></affiliation></author><author><name sortKey="Stolk, Ronald P" sort="Stolk, Ronald P" uniqKey="Stolk R" first="Ronald P" last="Stolk">Ronald P. Stolk</name><affiliation><nlm:aff id="A10">Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P" last="Strachan">David P. Strachan</name><affiliation><nlm:aff id="A29">Division of Population Health Sciences and Education, St. George’s, University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Tardif, Jean Claude" sort="Tardif, Jean Claude" uniqKey="Tardif J" first="Jean-Claude" last="Tardif">Jean-Claude Tardif</name><affiliation><nlm:aff id="A26">Université de Montréal, Montreal, Quebec, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Montreal Heart Institute, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation><nlm:aff id="A13">deCODE Genetics, Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A154">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Tuomilehto, Jaako" sort="Tuomilehto, Jaako" uniqKey="Tuomilehto J" first="Jaako" last="Tuomilehto">Jaako Tuomilehto</name><affiliation><nlm:aff id="A185">Diabetes Unit, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A186">Centre for Vascular Prevention, Danube-University Krems, Krems, Austria</nlm:aff></affiliation><affiliation><nlm:aff id="A187">Red Temática de Investigación Cooperativa en Enfermedades Cardiovasculares (Red RECAVA), Grupo RD06/0014/0015, Hospital Universitario La Paz, Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A188">King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Van Veldhuisen, Dirk J" sort="Van Veldhuisen, Dirk J" uniqKey="Van Veldhuisen D" first="Dirk J" last="Van Veldhuisen">Dirk J. Van Veldhuisen</name><affiliation><nlm:aff id="A31">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation><nlm:aff id="A48">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Viikari, Jorma" sort="Viikari, Jorma" uniqKey="Viikari J" first="Jorma" last="Viikari">Jorma Viikari</name><affiliation><nlm:aff id="A189">Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:aff id="A190">Department of Internal Medicine, University Hospital of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Waeber, Gerard" sort="Waeber, Gerard" uniqKey="Waeber G" first="Gérard" last="Waeber">Gérard Waeber</name><affiliation><nlm:aff id="A190">Department of Internal Medicine, University Hospital of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name><affiliation><nlm:aff id="A191">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Cho, Yoon Shin" sort="Cho, Yoon Shin" uniqKey="Cho Y" first="Yoon Shin" last="Cho">Yoon Shin Cho</name><affiliation><nlm:aff id="A192">Department of Biomedical Science, Hallym University, Chuncheon, Korea</nlm:aff></affiliation></author><author><name sortKey="Olsen, Jesper V" sort="Olsen, Jesper V" uniqKey="Olsen J" first="Jesper V" last="Olsen">Jesper V. Olsen</name><affiliation><nlm:aff id="A22">Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Visscher, Peter M" sort="Visscher, Peter M" uniqKey="Visscher P" first="Peter M" last="Visscher">Peter M. Visscher</name><affiliation><nlm:aff id="A193">Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Willer, Cristen" sort="Willer, Cristen" uniqKey="Willer C" first="Cristen" last="Willer">Cristen Willer</name><affiliation><nlm:aff id="A194">Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Franke, Lude" sort="Franke, Lude" uniqKey="Franke L" first="Lude" last="Franke">Lude Franke</name><affiliation><nlm:aff id="A15">Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A195">Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Erdmann, Jeanette" sort="Erdmann, Jeanette" uniqKey="Erdmann J" first="Jeanette" last="Erdmann">Jeanette Erdmann</name><affiliation><nlm:aff id="A90">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck)</nlm:aff></affiliation><affiliation><nlm:aff id="A197">Institute for Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A198">DZHK, partner site Hamburg/Kiel/Lübeck, Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Thompson, John R" sort="Thompson, John R" uniqKey="Thompson J" first="John R" last="Thompson">John R. Thompson</name><affiliation><nlm:aff id="A199">Department of Health Sciences, University of Leicester, Leicester, UK</nlm:aff></affiliation></author><author><name sortKey="Pfeufer, Arne" sort="Pfeufer, Arne" uniqKey="Pfeufer A" first="Arne" last="Pfeufer">Arne Pfeufer</name><affiliation><nlm:aff id="A200">Institute of Human Genetics, Helmholtz Zentrum München–german Research Center for Environmental Health, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A201">Institute of Human Genetics, Klinikum Rechts der Isar der Technischen Universitat München, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Sotoodehnia, Nona" sort="Sotoodehnia, Nona" uniqKey="Sotoodehnia N" first="Nona" last="Sotoodehnia">Nona Sotoodehnia</name><affiliation><nlm:aff id="A71">Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A202">Department of Medicine, Division of Cardiology, University of Washington School of Medicine, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Newton Cheh, Christopher" sort="Newton Cheh, Christopher" uniqKey="Newton Cheh C" first="Christopher" last="Newton-Cheh">Christopher Newton-Cheh</name><affiliation><nlm:aff id="A12">Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A110">National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A203">Center for Human Genetic Research, Cardiovacular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Ellinor, Patrick T" sort="Ellinor, Patrick T" uniqKey="Ellinor P" first="Patrick T" last="Ellinor">Patrick T. Ellinor</name><affiliation><nlm:aff id="A62">Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A204">Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A205">Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Stricker, Bruno H Ch" sort="Stricker, Bruno H Ch" uniqKey="Stricker B" first="Bruno H Ch" last="Stricker">Bruno H Ch Stricker</name><affiliation><nlm:aff id="A3">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Ageing, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A103">Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A140">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A206">Inspectorate of Health Care, The Hague, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation><nlm:aff id="A4">Estonian Biocenter, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A39">The Institute of Molecular Medicine, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Jacques S" sort="Beckmann, Jacques S" uniqKey="Beckmann J" first="Jacques S" last="Beckmann">Jacques S. Beckmann</name><affiliation><nlm:aff id="A37">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A207">Service of Medical Genetics, CHUV University Hospital, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><affiliation><nlm:aff id="A9">MRC Centre for Causal Analyses in Translational Epidemiology (CAiTE), School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><nlm:aff id="A13">deCODE Genetics, Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A154">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A1">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Munroe, Patricia B" sort="Munroe, Patricia B" uniqKey="Munroe P" first="Patricia B" last="Munroe">Patricia B. Munroe</name><affiliation><nlm:aff id="A16">Clinical Pharmacology, National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Sibon, Ody C M" sort="Sibon, Ody C M" uniqKey="Sibon O" first="Ody C M" last="Sibon">Ody C M. Sibon</name><affiliation><nlm:aff id="A99">Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Milan, David J" sort="Milan, David J" uniqKey="Milan D" first="David J" last="Milan">David J. Milan</name><affiliation><nlm:aff id="A8">Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A208">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation><nlm:aff id="A10">Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J" last="Samani">Nilesh J. Samani</name><affiliation><nlm:aff id="A209">Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A210">NIHR Leicester Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, UK</nlm:aff></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J F" last="Loos">Ruth J F. Loos</name><affiliation><nlm:aff id="A1">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A211">The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A212">The Charles Bronfman Institute of Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A213">The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23583979</idno><idno type="pmc">3696959</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696959</idno><idno type="RBID">PMC:3696959</idno><idno type="doi">10.1038/ng.2610</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">002143</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002143</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders</title><author><name sortKey="Den Hoed, Marcel" sort="Den Hoed, Marcel" uniqKey="Den Hoed M" first="Marcel" last="Den Hoed">Marcel Den Hoed</name><affiliation><nlm:aff id="A1">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Eijgelsheim, Mark" sort="Eijgelsheim, Mark" uniqKey="Eijgelsheim M" first="Mark" last="Eijgelsheim">Mark Eijgelsheim</name><affiliation><nlm:aff id="A3">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation><nlm:aff id="A4">Estonian Biocenter, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Brundel, Bianca J J M" sort="Brundel, Bianca J J M" uniqKey="Brundel B" first="Bianca J J M" last="Brundel">Bianca J J M. Brundel</name><affiliation><nlm:aff id="A7">Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Peal, David S" sort="Peal, David S" uniqKey="Peal D" first="David S" last="Peal">David S. Peal</name><affiliation><nlm:aff id="A8">Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M" last="Evans">David M. Evans</name><affiliation><nlm:aff id="A9">MRC Centre for Causal Analyses in Translational Epidemiology (CAiTE), School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M" last="Nolte">Ilja M. Nolte</name><affiliation><nlm:aff id="A10">Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Segre, Ayellet V" sort="Segre, Ayellet V" uniqKey="Segre A" first="Ayellet V" last="Segrè">Ayellet V. Segrè</name><affiliation><nlm:aff id="A11">Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Holm, Hilma" sort="Holm, Hilma" uniqKey="Holm H" first="Hilma" last="Holm">Hilma Holm</name><affiliation><nlm:aff id="A13">deCODE Genetics, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Handsaker, Robert E" sort="Handsaker, Robert E" uniqKey="Handsaker R" first="Robert E" last="Handsaker">Robert E. Handsaker</name><affiliation><nlm:aff id="A12">Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Westra, Harm Jan" sort="Westra, Harm Jan" uniqKey="Westra H" first="Harm-Jan" last="Westra">Harm-Jan Westra</name><affiliation><nlm:aff id="A15">Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name><affiliation><nlm:aff id="A16">Clinical Pharmacology, National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name><affiliation><nlm:aff id="A3">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Centre for Medical Systems Biology, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Yang, Jian" sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name><affiliation><nlm:aff id="A19">Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Lundby, Alicia" sort="Lundby, Alicia" uniqKey="Lundby A" first="Alicia" last="Lundby">Alicia Lundby</name><affiliation><nlm:aff id="A20">Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A21">The Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="A1">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Kim, Young Jin" sort="Kim, Young Jin" uniqKey="Kim Y" first="Young Jin" last="Kim">Young Jin Kim</name><affiliation><nlm:aff id="A23">Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Daejeon, The Republic of Korea</nlm:aff></affiliation></author><author><name sortKey="Go, Min Jin" sort="Go, Min Jin" uniqKey="Go M" first="Min Jin" last="Go">Min Jin Go</name><affiliation><nlm:aff id="A23">Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Daejeon, The Republic of Korea</nlm:aff></affiliation></author><author><name sortKey="Almgren, Peter" sort="Almgren, Peter" uniqKey="Almgren P" first="Peter" last="Almgren">Peter Almgren</name><affiliation><nlm:aff id="A24">Department of Clinical Sciences, Diabetes and Endocrinology, Lund University and Lund University Diabetes Centre, Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name><affiliation><nlm:aff id="A25">Community Prevention Unit, Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Boucher, Gabrielle" sort="Boucher, Gabrielle" uniqKey="Boucher G" first="Gabrielle" last="Boucher">Gabrielle Boucher</name><affiliation><nlm:aff id="A26">Université de Montréal, Montreal, Quebec, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Montreal Heart Institute, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Cornelis, Marilyn C" sort="Cornelis, Marilyn C" uniqKey="Cornelis M" first="Marilyn C" last="Cornelis">Marilyn C. Cornelis</name><affiliation><nlm:aff id="A28">Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Gudbjartsson, Daniel" sort="Gudbjartsson, Daniel" uniqKey="Gudbjartsson D" first="Daniel" last="Gudbjartsson">Daniel Gudbjartsson</name><affiliation><nlm:aff id="A13">deCODE Genetics, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Hadley, David" sort="Hadley, David" uniqKey="Hadley D" first="David" last="Hadley">David Hadley</name><affiliation><nlm:aff id="A29">Division of Population Health Sciences and Education, St. George’s, University of London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Pediatric Epidemiology Center, University of South Florida, Tampa, Florida, USA</nlm:aff></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation><nlm:aff id="A31">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="A32">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Heijer, Martin Den" sort="Heijer, Martin Den" uniqKey="Heijer M" first="Martin Den" last="Heijer">Martin Den Heijer</name><affiliation><nlm:aff id="A33">Department of Internal Medicine, VU Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Igl, Wilmar" sort="Igl, Wilmar" uniqKey="Igl W" first="Wilmar" last="Igl">Wilmar Igl</name><affiliation><nlm:aff id="A34">Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Jackson, Anne U" sort="Jackson, Anne U" uniqKey="Jackson A" first="Anne U" last="Jackson">Anne U. Jackson</name><affiliation><nlm:aff id="A35">Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name><affiliation><nlm:aff id="A37">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Swiss Institute of Bioinformatics, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Luan, Jian N" sort="Luan, Jian N" uniqKey="Luan J" first="Jian N" last="Luan">Jian N Luan</name><affiliation><nlm:aff id="A1">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Kemp, John P" sort="Kemp, John P" uniqKey="Kemp J" first="John P" last="Kemp">John P. Kemp</name><affiliation><nlm:aff id="A9">MRC Centre for Causal Analyses in Translational Epidemiology (CAiTE), School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Kristiansson, Kati" sort="Kristiansson, Kati" uniqKey="Kristiansson K" first="Kati" last="Kristiansson">Kati Kristiansson</name><affiliation><nlm:aff id="A39">The Institute of Molecular Medicine, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Ladenvall, Claes" sort="Ladenvall, Claes" uniqKey="Ladenvall C" first="Claes" last="Ladenvall">Claes Ladenvall</name><affiliation><nlm:aff id="A24">Department of Clinical Sciences, Diabetes and Endocrinology, Lund University and Lund University Diabetes Centre, Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lorentzon, Mattias" sort="Lorentzon, Mattias" uniqKey="Lorentzon M" first="Mattias" last="Lorentzon">Mattias Lorentzon</name><affiliation><nlm:aff id="A41">Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Montasser, May E" sort="Montasser, May E" uniqKey="Montasser M" first="May E" last="Montasser">May E. Montasser</name><affiliation><nlm:aff id="A42">Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland, School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Njajou, Omer T" sort="Njajou, Omer T" uniqKey="Njajou O" first="Omer T" last="Njajou">Omer T. Njajou</name><affiliation><nlm:aff id="A43">Department of Medicine, Institute for Human Genetics, University of California, San Francisco, San Francisco, California, USA</nlm:aff></affiliation></author><author><name sortKey="O Eilly, Paul F" sort="O Eilly, Paul F" uniqKey="O Eilly P" first="Paul F" last="O Eilly">Paul F. O Eilly</name><affiliation><nlm:aff id="A44">Department of Epidemiology and Biostatistics, Imperial College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A45">MRC–Health Protection Agency (MRC-HPA) Centre for Environment and Health, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Padmanabhan, Sandosh" sort="Padmanabhan, Sandosh" uniqKey="Padmanabhan S" first="Sandosh" last="Padmanabhan">Sandosh Padmanabhan</name><affiliation><nlm:aff id="A46">Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Pourcain, Beate St" sort="Pourcain, Beate St" uniqKey="Pourcain B" first="Beate St." last="Pourcain">Beate St. Pourcain</name><affiliation><nlm:aff id="A9">MRC Centre for Causal Analyses in Translational Epidemiology (CAiTE), School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Rankinen, Tuomo" sort="Rankinen, Tuomo" uniqKey="Rankinen T" first="Tuomo" last="Rankinen">Tuomo Rankinen</name><affiliation><nlm:aff id="A47">Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA</nlm:aff></affiliation></author><author><name sortKey="Salo, Perttu" sort="Salo, Perttu" uniqKey="Salo P" first="Perttu" last="Salo">Perttu Salo</name><affiliation><nlm:aff id="A39">The Institute of Molecular Medicine, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation><nlm:aff id="A49">Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J" last="Timpson">Nicholas J. Timpson</name><affiliation><nlm:aff id="A9">MRC Centre for Causal Analyses in Translational Epidemiology (CAiTE), School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation><nlm:aff id="A32">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Waite, Lindsay" sort="Waite, Lindsay" uniqKey="Waite L" first="Lindsay" last="Waite">Lindsay Waite</name><affiliation><nlm:aff id="A50">HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA</nlm:aff></affiliation></author><author><name sortKey="Wheeler, William" sort="Wheeler, William" uniqKey="Wheeler W" first="William" last="Wheeler">William Wheeler</name><affiliation><nlm:aff id="A51">Information Management Services, Inc., Rockville, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><affiliation><nlm:aff id="A44">Department of Epidemiology and Biostatistics, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Draisma, Harmen H M" sort="Draisma, Harmen H M" uniqKey="Draisma H" first="Harmen H M" last="Draisma">Harmen H M. Draisma</name><affiliation><nlm:aff id="A52">Department of Biological Psychology, VU University Amsterdam and Institute for Health and Care Research (EMGO+), VU Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Feitosa, Mary F" sort="Feitosa, Mary F" uniqKey="Feitosa M" first="Mary F" last="Feitosa">Mary F. Feitosa</name><affiliation><nlm:aff id="A53">Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="Kerr, Kathleen F" sort="Kerr, Kathleen F" uniqKey="Kerr K" first="Kathleen F" last="Kerr">Kathleen F. Kerr</name><affiliation><nlm:aff id="A54">Department of Biostatistics, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Lind, Penelope A" sort="Lind, Penelope A" uniqKey="Lind P" first="Penelope A" last="Lind">Penelope A. Lind</name><affiliation><nlm:aff id="A55">Quantitative Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Mihailov, Evelin" sort="Mihailov, Evelin" uniqKey="Mihailov E" first="Evelin" last="Mihailov">Evelin Mihailov</name><affiliation><nlm:aff id="A4">Estonian Biocenter, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N Charlotte" last="Onland-Moret">N Charlotte Onland-Moret</name><affiliation><nlm:aff id="A56">Complex Genetics Section, Department of Medical Genetics–de Bakker Group, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Song, Ci" sort="Song, Ci" uniqKey="Song C" first="Ci" last="Song">Ci Song</name><affiliation><nlm:aff id="A58">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Weedon, Michael N" sort="Weedon, Michael N" uniqKey="Weedon M" first="Michael N" last="Weedon">Michael N. Weedon</name><affiliation><nlm:aff id="A59">Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff></affiliation></author><author><name sortKey="Xie, Weijia" sort="Xie, Weijia" uniqKey="Xie W" first="Weijia" last="Xie">Weijia Xie</name><affiliation><nlm:aff id="A59">Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff></affiliation></author><author><name sortKey="Yengo, Loic" sort="Yengo, Loic" uniqKey="Yengo L" first="Loic" last="Yengo">Loic Yengo</name><affiliation><nlm:aff id="A60">Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8199, Institut Pasteur de Lille, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Absher, Devin" sort="Absher, Devin" uniqKey="Absher D" first="Devin" last="Absher">Devin Absher</name><affiliation><nlm:aff id="A50">HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA</nlm:aff></affiliation></author><author><name sortKey="Albert, Christine M" sort="Albert, Christine M" uniqKey="Albert C" first="Christine M" last="Albert">Christine M. Albert</name><affiliation><nlm:aff id="A61">Division of Preventive Medicine, Cardiovascular Division, Brigham and Women’s Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Alonso, Alvaro" sort="Alonso, Alvaro" uniqKey="Alonso A" first="Alvaro" last="Alonso">Alvaro Alonso</name><affiliation><nlm:aff id="A63">Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Arking, Dan E" sort="Arking, Dan E" uniqKey="Arking D" first="Dan E" last="Arking">Dan E. Arking</name><affiliation><nlm:aff id="A64">Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A65">McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I W" last="De Bakker">Paul I W. De Bakker</name><affiliation><nlm:aff id="A12">Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Department of Medicine, Division of Genetics, Brigham and Women’s Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Department of Medical Genetics, Division of Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><affiliation><nlm:aff id="A68">Institut National de la Santé et de la Recherche Médicale (INSERM), CESP Centre for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease over The Lifecourse, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A69">UMRS 1018, Université Paris–Sud 11, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Barlassina, Cristina" sort="Barlassina, Cristina" uniqKey="Barlassina C" first="Cristina" last="Barlassina">Cristina Barlassina</name><affiliation><nlm:aff id="A70">Department of Health Sciences, Milan University and Filarete Foundation, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Benaglio, Paola" sort="Benaglio, Paola" uniqKey="Benaglio P" first="Paola" last="Benaglio">Paola Benaglio</name><affiliation><nlm:aff id="A37">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C" last="Bis">Joshua C. Bis</name><affiliation><nlm:aff id="A71">Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Department of Medicine, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name><affiliation><nlm:aff id="A60">Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8199, Institut Pasteur de Lille, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Lille Nord de France University, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A74">INSERM U970, Paris Cardiovascular Research Centre, Hopital Européen Georges Pampidou, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Brage, S Ren" sort="Brage, S Ren" uniqKey="Brage S" first="S Ren" last="Brage">S Ren Brage</name><affiliation><nlm:aff id="A1">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="A75">Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, Maryland, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Chines, Peter S" sort="Chines, Peter S" uniqKey="Chines P" first="Peter S" last="Chines">Peter S. Chines</name><affiliation><nlm:aff id="A77">National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Chung, Mina" sort="Chung, Mina" uniqKey="Chung M" first="Mina" last="Chung">Mina Chung</name><affiliation><nlm:aff id="A78">Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A79">Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA</nlm:aff></affiliation></author><author><name sortKey="Darbar, Dawood" sort="Darbar, Dawood" uniqKey="Darbar D" first="Dawood" last="Darbar">Dawood Darbar</name><affiliation><nlm:aff id="A80">Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA</nlm:aff></affiliation></author><author><name sortKey="Dina, Christian" sort="Dina, Christian" uniqKey="Dina C" first="Christian" last="Dina">Christian Dina</name><affiliation><nlm:aff id="A81">INSERM U1087, CNRS U6291 and University of Nantes, l’Institut du Thorax, Nantes, France</nlm:aff></affiliation><affiliation><nlm:aff id="A82">Centre Hospitalier Universitaire (CHU) Nantes, l’Institut du Thorax, Nantes, France</nlm:aff></affiliation></author><author><name sortKey="Dorr, Marcus" sort="Dorr, Marcus" uniqKey="Dorr M" first="Marcus" last="Dörr">Marcus Dörr</name><affiliation><nlm:aff id="A83">Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A84">DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation><nlm:aff id="A44">Department of Epidemiology and Biostatistics, Imperial College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A45">MRC–Health Protection Agency (MRC-HPA) Centre for Environment and Health, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Felix, Stephan B" sort="Felix, Stephan B" uniqKey="Felix S" first="Stephan B" last="Felix">Stephan B. Felix</name><affiliation><nlm:aff id="A83">Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A84">DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Fuchsberger, Christian" sort="Fuchsberger, Christian" uniqKey="Fuchsberger C" first="Christian" last="Fuchsberger">Christian Fuchsberger</name><affiliation><nlm:aff id="A35">Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J C" last="De Geus">Eco J C. De Geus</name><affiliation><nlm:aff id="A52">Department of Biological Psychology, VU University Amsterdam and Institute for Health and Care Research (EMGO+), VU Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Goyette, Philippe" sort="Goyette, Philippe" uniqKey="Goyette P" first="Philippe" last="Goyette">Philippe Goyette</name><affiliation><nlm:aff id="A26">Université de Montréal, Montreal, Quebec, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Montreal Heart Institute, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="A85">Icelandic Heart Association Research Institute, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A86">University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="A87">Laboratory for Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation><nlm:aff id="A88">Department of Clinical Sciences, Obstetrics and Gynecology, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Havulinna, Aki S" sort="Havulinna, Aki S" uniqKey="Havulinna A" first="Aki S" last="Havulinna">Aki S. Havulinna</name><affiliation><nlm:aff id="A48">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Heckbert, Susan R" sort="Heckbert, Susan R" uniqKey="Heckbert S" first="Susan R" last="Heckbert">Susan R. Heckbert</name><affiliation><nlm:aff id="A71">Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A89">Department of Epidemiology, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A" last="Hicks">Andrew A. Hicks</name><affiliation><nlm:aff id="A90">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck)</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A3">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Ageing, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Holewijn, Suzanne" sort="Holewijn, Suzanne" uniqKey="Holewijn S" first="Suzanne" last="Holewijn">Suzanne Holewijn</name><affiliation><nlm:aff id="A92">Department of General Internal Medicine, Division of Vascular Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hoogstra Berends, Femke" sort="Hoogstra Berends, Femke" uniqKey="Hoogstra Berends F" first="Femke" last="Hoogstra-Berends">Femke Hoogstra-Berends</name><affiliation><nlm:aff id="A7">Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A93">Nyken, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation><nlm:aff id="A52">Department of Biological Psychology, VU University Amsterdam and Institute for Health and Care Research (EMGO+), VU Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Jensen, Majken K" sort="Jensen, Majken K" uniqKey="Jensen M" first="Majken K" last="Jensen">Majken K. Jensen</name><affiliation><nlm:aff id="A28">Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation><nlm:aff id="A34">Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A94">Uppsala Clinical Research Center, Uppsala University Hospital, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Junttila, Juhani" sort="Junttila, Juhani" uniqKey="Junttila J" first="Juhani" last="Junttila">Juhani Junttila</name><affiliation><nlm:aff id="A95">Division of Cardiology, Miller School of Medicine, University of Miami, Miami, Florida, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A96">Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="K B, Stefan" sort="K B, Stefan" uniqKey="K B S" first="Stefan" last="K B">Stefan K B</name><affiliation><nlm:aff id="A97">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians- Universität, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A98">Munich Heart Alliance, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Kanon, Bart" sort="Kanon, Bart" uniqKey="Kanon B" first="Bart" last="Kanon">Bart Kanon</name><affiliation><nlm:aff id="A99">Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Ketkar, Shamika" sort="Ketkar, Shamika" uniqKey="Ketkar S" first="Shamika" last="Ketkar">Shamika Ketkar</name><affiliation><nlm:aff id="A53">Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:aff id="A100">Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Knowles, Joshua W" sort="Knowles, Joshua W" uniqKey="Knowles J" first="Joshua W" last="Knowles">Joshua W. Knowles</name><affiliation><nlm:aff id="A101">Department of Medicine, Stanford University School of Medicine, Stanford, California, USA</nlm:aff></affiliation></author><author><name sortKey="Kooner, Angrad S" sort="Kooner, Angrad S" uniqKey="Kooner A" first="Angrad S" last="Kooner">Angrad S. Kooner</name><affiliation><nlm:aff id="A102">Cardiology Department, Ealing Hospital National Health Service (NHS) Trust, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kors, Jan A" sort="Kors, Jan A" uniqKey="Kors J" first="Jan A" last="Kors">Jan A. Kors</name><affiliation><nlm:aff id="A103">Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name><affiliation><nlm:aff id="A104">Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Milani, Lili" sort="Milani, Lili" uniqKey="Milani L" first="Lili" last="Milani">Lili Milani</name><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Laiho, P Ivi" sort="Laiho, P Ivi" uniqKey="Laiho P" first="P Ivi" last="Laiho">P Ivi Laiho</name><affiliation><nlm:aff id="A105">National Public Health Institute, Biomedicum Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Lakatta, Edward G" sort="Lakatta, Edward G" uniqKey="Lakatta E" first="Edward G" last="Lakatta">Edward G. Lakatta</name><affiliation><nlm:aff id="A106">Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation><nlm:aff id="A1">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Leusink, Maarten" sort="Leusink, Maarten" uniqKey="Leusink M" first="Maarten" last="Leusink">Maarten Leusink</name><affiliation><nlm:aff id="A57">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A107">Division Pharmacoepidemiology & Clinical Pharmacology, Utrecht University, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation><nlm:aff id="A108">Department of Epidemiology & Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina, USA</nlm:aff></affiliation></author><author><name sortKey="Luben, Robert N" sort="Luben, Robert N" uniqKey="Luben R" first="Robert N" last="Luben">Robert N. Luben</name><affiliation><nlm:aff id="A100">Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Lunetta, Kathryn L" sort="Lunetta, Kathryn L" uniqKey="Lunetta K" first="Kathryn L" last="Lunetta">Kathryn L. Lunetta</name><affiliation><nlm:aff id="A109">Department of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A110">National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Lynch, Stacey N" sort="Lynch, Stacey N" uniqKey="Lynch S" first="Stacey N" last="Lynch">Stacey N. Lynch</name><affiliation><nlm:aff id="A8">Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Markus, Marcello R P" sort="Markus, Marcello R P" uniqKey="Markus M" first="Marcello R P" last="Markus">Marcello R P. Markus</name><affiliation><nlm:aff id="A111">Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Marques Vidal, Pedro" sort="Marques Vidal, Pedro" uniqKey="Marques Vidal P" first="Pedro" last="Marques-Vidal">Pedro Marques-Vidal</name><affiliation><nlm:aff id="A112">Institut Universitaire de Médecine Sociale et Préventive (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Leach, Irene Mateo" sort="Leach, Irene Mateo" uniqKey="Leach I" first="Irene Mateo" last="Leach">Irene Mateo Leach</name><affiliation><nlm:aff id="A31">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L" last="Mcardle">Wendy L. Mcardle</name><affiliation><nlm:aff id="A113">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Mccarroll, Steven A" sort="Mccarroll, Steven A" uniqKey="Mccarroll S" first="Steven A" last="Mccarroll">Steven A. Mccarroll</name><affiliation><nlm:aff id="A12">Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E" last="Medland">Sarah E. Medland</name><affiliation><nlm:aff id="A20">Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Quantitative Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Miller, Kathryn A" sort="Miller, Kathryn A" uniqKey="Miller K" first="Kathryn A" last="Miller">Kathryn A. Miller</name><affiliation><nlm:aff id="A44">Department of Epidemiology and Biostatistics, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W" last="Montgomery">Grant W. Montgomery</name><affiliation><nlm:aff id="A114">Molecular Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Morrison, Alanna C" sort="Morrison, Alanna C" uniqKey="Morrison A" first="Alanna C" last="Morrison">Alanna C. Morrison</name><affiliation><nlm:aff id="A115">Human Genetics Center, University of Texas Health Science Center, Houston, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name><affiliation><nlm:aff id="A97">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians- Universität, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A116">Chair of Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A117">Institute of Genetic Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Navarro, Pau" sort="Navarro, Pau" uniqKey="Navarro P" first="Pau" last="Navarro">Pau Navarro</name><affiliation><nlm:aff id="A32">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Nelis, Mari" sort="Nelis, Mari" uniqKey="Nelis M" first="Mari" last="Nelis">Mari Nelis</name><affiliation><nlm:aff id="A4">Estonian Biocenter, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A118">Department of Medical Genetics and Development, University of Geneva Medical School, Geneva, Switzerland</nlm:aff></affiliation></author><author><name sortKey="O Onnell, Jeffrey R" sort="O Onnell, Jeffrey R" uniqKey="O Onnell J" first="Jeffrey R" last="O Onnell">Jeffrey R. O Onnell</name><affiliation><nlm:aff id="A42">Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland, School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="O Onnell, Christopher J" sort="O Onnell, Christopher J" uniqKey="O Onnell C" first="Christopher J" last="O Onnell">Christopher J. O Onnell</name><affiliation><nlm:aff id="A110">National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A119">Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A120">National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Ong, Ken K" sort="Ong, Ken K" uniqKey="Ong K" first="Ken K" last="Ong">Ken K. Ong</name><affiliation><nlm:aff id="A1">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A121">MRC Unit for Lifelong Health and Ageing, London, UK</nlm:aff></affiliation></author><author><name sortKey="Newman, Anne B" sort="Newman, Anne B" uniqKey="Newman A" first="Anne B" last="Newman">Anne B. Newman</name><affiliation><nlm:aff id="A122">Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name><affiliation><nlm:aff id="A98">Munich Heart Alliance, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A123">Institute of Epidemiology II, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation><nlm:aff id="A124">Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation><nlm:aff id="A88">Department of Clinical Sciences, Obstetrics and Gynecology, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A125">National Institute for Health and Welfare, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P" last="Pramstaller">Peter P. Pramstaller</name><affiliation><nlm:aff id="A90">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck)</nlm:aff></affiliation><affiliation><nlm:aff id="A126">Department of Neurology, General Central Hospital, Bolzano, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A127">Department of Neurology, University of Lübeck, Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name><affiliation><nlm:aff id="A71">Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Department of Medicine, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A89">Department of Epidemiology, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A128">Group Health Research Institute, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A129">Department of Health Services, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Rao, Dabeeru C" sort="Rao, Dabeeru C" uniqKey="Rao D" first="Dabeeru C" last="Rao">Dabeeru C. Rao</name><affiliation><nlm:aff id="A130">Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M" last="Ring">Susan M. Ring</name><affiliation><nlm:aff id="A113">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Rossin, Elizabeth J" sort="Rossin, Elizabeth J" uniqKey="Rossin E" first="Elizabeth J" last="Rossin">Elizabeth J. Rossin</name><affiliation><nlm:aff id="A20">Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A131">Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A132">Harvard Biological and Biomedical Sciences Program, Harvard University, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A133">Health Science and Technology M.D. Program, Harvard University and Massachusetts Institute of Technology, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Rudan, Diana" sort="Rudan, Diana" uniqKey="Rudan D" first="Diana" last="Rudan">Diana Rudan</name><affiliation><nlm:aff id="A134">Department of Pathophysiology, Faculty of Medicine, University of Split, Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation><nlm:aff id="A135">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy</nlm:aff></affiliation></author><author><name sortKey="Scott, Robert A" sort="Scott, Robert A" uniqKey="Scott R" first="Robert A" last="Scott">Robert A. Scott</name><affiliation><nlm:aff id="A1">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Sehmi, Jaban S" sort="Sehmi, Jaban S" uniqKey="Sehmi J" first="Jaban S" last="Sehmi">Jaban S. Sehmi</name><affiliation><nlm:aff id="A102">Cardiology Department, Ealing Hospital National Health Service (NHS) Trust, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A136">National Heart and Lung Institute, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Sharp, Stephen" sort="Sharp, Stephen" uniqKey="Sharp S" first="Stephen" last="Sharp">Stephen Sharp</name><affiliation><nlm:aff id="A1">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Shin, Jordan T" sort="Shin, Jordan T" uniqKey="Shin J" first="Jordan T" last="Shin">Jordan T. Shin</name><affiliation><nlm:aff id="A8">Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Singleton, Andrew B" sort="Singleton, Andrew B" uniqKey="Singleton A" first="Andrew B" last="Singleton">Andrew B. Singleton</name><affiliation><nlm:aff id="A137">Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V" last="Smith">Albert V. Smith</name><affiliation><nlm:aff id="A85">Icelandic Heart Association Research Institute, Kopavogur, Iceland</nlm:aff></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation><nlm:aff id="A19">Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A138">Department of Twin Research and Genetic Epidemiology Unit, St. Thomas’ Campus, King’s College London, St. Thomas’ Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D" last="Spector">Tim D. Spector</name><affiliation><nlm:aff id="A138">Department of Twin Research and Genetic Epidemiology Unit, St. Thomas’ Campus, King’s College London, St. Thomas’ Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Stewart, Chip" sort="Stewart, Chip" uniqKey="Stewart C" first="Chip" last="Stewart">Chip Stewart</name><affiliation><nlm:aff id="A20">Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A139">Biology Department, Boston College, Chestnut Hill, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Stringham, Heather M" sort="Stringham, Heather M" uniqKey="Stringham H" first="Heather M" last="Stringham">Heather M. Stringham</name><affiliation><nlm:aff id="A35">Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Tarasov, Kirill V" sort="Tarasov, Kirill V" uniqKey="Tarasov K" first="Kirill V" last="Tarasov">Kirill V. Tarasov</name><affiliation><nlm:aff id="A106">Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G" last="Uitterlinden">André G. Uitterlinden</name><affiliation><nlm:aff id="A3">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Ageing, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A140">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Vandenput, Liesbeth" sort="Vandenput, Liesbeth" uniqKey="Vandenput L" first="Liesbeth" last="Vandenput">Liesbeth Vandenput</name><affiliation><nlm:aff id="A41">Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name><affiliation><nlm:aff id="A110">National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B" last="Whitfield">John B. Whitfield</name><affiliation><nlm:aff id="A141">genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Wijmenga, Cisca" sort="Wijmenga, Cisca" uniqKey="Wijmenga C" first="Cisca" last="Wijmenga">Cisca Wijmenga</name><affiliation><nlm:aff id="A15">Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H" last="Wild">Sarah H. Wild</name><affiliation><nlm:aff id="A142">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation><nlm:aff id="A52">Department of Biological Psychology, VU University Amsterdam and Institute for Health and Care Research (EMGO+), VU Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="A142">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Witteman, Jacqueline C M" sort="Witteman, Jacqueline C M" uniqKey="Witteman J" first="Jacqueline C M" last="Witteman">Jacqueline C M. Witteman</name><affiliation><nlm:aff id="A3">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Ageing, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wong, Andrew" sort="Wong, Andrew" uniqKey="Wong A" first="Andrew" last="Wong">Andrew Wong</name><affiliation><nlm:aff id="A121">MRC Unit for Lifelong Health and Ageing, London, UK</nlm:aff></affiliation></author><author><name sortKey="Wong, Quenna" sort="Wong, Quenna" uniqKey="Wong Q" first="Quenna" last="Wong">Quenna Wong</name><affiliation><nlm:aff id="A54">Department of Biostatistics, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Jamshidi, Yalda" sort="Jamshidi, Yalda" uniqKey="Jamshidi Y" first="Yalda" last="Jamshidi">Yalda Jamshidi</name><affiliation><nlm:aff id="A138">Department of Twin Research and Genetic Epidemiology Unit, St. Thomas’ Campus, King’s College London, St. Thomas’ Hospital, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A143">Division of Biomedical Sciences, St. George’s University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Zitting, Paavo" sort="Zitting, Paavo" uniqKey="Zitting P" first="Paavo" last="Zitting">Paavo Zitting</name><affiliation><nlm:aff id="A144">Department of Physiatrics, Lapland Central Hospital, Rovaniemi, Finland</nlm:aff></affiliation></author><author><name sortKey="Boer, Jolanda M A" sort="Boer, Jolanda M A" uniqKey="Boer J" first="Jolanda M A" last="Boer">Jolanda M A. Boer</name><affiliation><nlm:aff id="A145">Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I" last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:aff id="A52">Department of Biological Psychology, VU University Amsterdam and Institute for Health and Care Research (EMGO+), VU Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Borecki, Ingrid B" sort="Borecki, Ingrid B" uniqKey="Borecki I" first="Ingrid B" last="Borecki">Ingrid B. Borecki</name><affiliation><nlm:aff id="A53">Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A3">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Centre for Medical Systems Biology, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Ekelund, Ulf" sort="Ekelund, Ulf" uniqKey="Ekelund U" first="Ulf" last="Ekelund">Ulf Ekelund</name><affiliation><nlm:aff id="A1">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A146">Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Forouhi, Nita G" sort="Forouhi, Nita G" uniqKey="Forouhi N" first="Nita G" last="Forouhi">Nita G. Forouhi</name><affiliation><nlm:aff id="A1">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="A60">Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8199, Institut Pasteur de Lille, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Lille Nord de France University, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A147">Genomic Medicine, Hammersmith Hospital, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Hingorani, Aroon" sort="Hingorani, Aroon" uniqKey="Hingorani A" first="Aroon" last="Hingorani">Aroon Hingorani</name><affiliation><nlm:aff id="A104">Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation><nlm:aff id="A2">Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A58">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A148">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name><affiliation><nlm:aff id="A104">Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kronmal, Richard A" sort="Kronmal, Richard A" uniqKey="Kronmal R" first="Richard A" last="Kronmal">Richard A. Kronmal</name><affiliation><nlm:aff id="A54">Department of Biostatistics, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Kuh, Diana" sort="Kuh, Diana" uniqKey="Kuh D" first="Diana" last="Kuh">Diana Kuh</name><affiliation><nlm:aff id="A121">MRC Unit for Lifelong Health and Ageing, London, UK</nlm:aff></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation><nlm:aff id="A149">Department of Medical Sciences, Uppsala University, Akademiska Sjukhuset, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="A141">genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A" last="Oostra">Ben A. Oostra</name><affiliation><nlm:aff id="A150">Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L" last="Pedersen">Nancy L. Pedersen</name><affiliation><nlm:aff id="A58">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Quertermous, Thomas" sort="Quertermous, Thomas" uniqKey="Quertermous T" first="Thomas" last="Quertermous">Thomas Quertermous</name><affiliation><nlm:aff id="A101">Department of Medicine, Stanford University School of Medicine, Stanford, California, USA</nlm:aff></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I" last="Rotter">Jerome I. Rotter</name><affiliation><nlm:aff id="A151">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Van Der Schouw, Yvonne T" sort="Van Der Schouw, Yvonne T" uniqKey="Van Der Schouw Y" first="Yvonne T" last="Van Der Schouw">Yvonne T. Van Der Schouw</name><affiliation><nlm:aff id="A57">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Verschuren, W M Monique" sort="Verschuren, W M Monique" uniqKey="Verschuren W" first="W M Monique" last="Verschuren">W M Monique Verschuren</name><affiliation><nlm:aff id="A145">Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Walker, Mark" sort="Walker, Mark" uniqKey="Walker M" first="Mark" last="Walker">Mark Walker</name><affiliation><nlm:aff id="A152">Institue of Cellular Medicine, Newcastle University, Newcastle, UK</nlm:aff></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation><nlm:aff id="A75">Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Arnar, David O" sort="Arnar, David O" uniqKey="Arnar D" first="David O" last="Arnar">David O. Arnar</name><affiliation><nlm:aff id="A153">Department of Medicine, Landspitali University Hospital, Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A154">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Assimes, Themistocles L" sort="Assimes, Themistocles L" uniqKey="Assimes T" first="Themistocles L" last="Assimes">Themistocles L. Assimes</name><affiliation><nlm:aff id="A101">Department of Medicine, Stanford University School of Medicine, Stanford, California, USA</nlm:aff></affiliation></author><author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name><affiliation><nlm:aff id="A155">Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Boehnke, Michael" sort="Boehnke, Michael" uniqKey="Boehnke M" first="Michael" last="Boehnke">Michael Boehnke</name><affiliation><nlm:aff id="A35">Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="De Boer, Rudolf A" sort="De Boer, Rudolf A" uniqKey="De Boer R" first="Rudolf A" last="De Boer">Rudolf A. De Boer</name><affiliation><nlm:aff id="A31">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Bouchard, Claude" sort="Bouchard, Claude" uniqKey="Bouchard C" first="Claude" last="Bouchard">Claude Bouchard</name><affiliation><nlm:aff id="A47">Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA</nlm:aff></affiliation></author><author><name sortKey="Caulfield, W L Mark" sort="Caulfield, W L Mark" uniqKey="Caulfield W" first="W L Mark" last="Caulfield">W L Mark Caulfield</name><affiliation><nlm:aff id="A16">Clinical Pharmacology, National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Chambers, John C" sort="Chambers, John C" uniqKey="Chambers J" first="John C" last="Chambers">John C. Chambers</name><affiliation><nlm:aff id="A44">Department of Epidemiology and Biostatistics, Imperial College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A102">Cardiology Department, Ealing Hospital National Health Service (NHS) Trust, London, UK</nlm:aff></affiliation></author><author><name sortKey="Curhan, Gary" sort="Curhan, Gary" uniqKey="Curhan G" first="Gary" last="Curhan">Gary Curhan</name><affiliation><nlm:aff id="A156">Channing Laboratory and Renal Division, Brigham and Women’s Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A157">Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Cusi, Daniele" sort="Cusi, Daniele" uniqKey="Cusi D" first="Daniele" last="Cusi">Daniele Cusi</name><affiliation><nlm:aff id="A70">Department of Health Sciences, Milan University and Filarete Foundation, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Johan" sort="Eriksson, Johan" uniqKey="Eriksson J" first="Johan" last="Eriksson">Johan Eriksson</name><affiliation><nlm:aff id="A48">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A158">Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A159">Folkhälsan Research Centre, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A160">Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation><nlm:aff id="A49">Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Van Gilst, Wiek H" sort="Van Gilst, Wiek H" uniqKey="Van Gilst W" first="Wiek H" last="Van Gilst">Wiek H. Van Gilst</name><affiliation><nlm:aff id="A31">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Glorioso, Nicola" sort="Glorioso, Nicola" uniqKey="Glorioso N" first="Nicola" last="Glorioso">Nicola Glorioso</name><affiliation><nlm:aff id="A161">Hypertension and Related Diseases Centre–Azienda Ospedaliero Universitaria (AOU), University of Sassari, Sassari, Italy</nlm:aff></affiliation></author><author><name sortKey="De Graaf, Jacqueline" sort="De Graaf, Jacqueline" uniqKey="De Graaf J" first="Jacqueline" last="De Graaf">Jacqueline De Graaf</name><affiliation><nlm:aff id="A92">Department of General Internal Medicine, Division of Vascular Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Groop, Leif" sort="Groop, Leif" uniqKey="Groop L" first="Leif" last="Groop">Leif Groop</name><affiliation><nlm:aff id="A24">Department of Clinical Sciences, Diabetes and Endocrinology, Lund University and Lund University Diabetes Centre, Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation><nlm:aff id="A34">Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hsueh, Wen Chi" sort="Hsueh, Wen Chi" uniqKey="Hsueh W" first="Wen-Chi" last="Hsueh">Wen-Chi Hsueh</name><affiliation><nlm:aff id="A43">Department of Medicine, Institute for Human Genetics, University of California, San Francisco, San Francisco, California, USA</nlm:aff></affiliation></author><author><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B" last="Hu">Frank B. Hu</name><affiliation><nlm:aff id="A28">Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Huikuri, Heikki V" sort="Huikuri, Heikki V" uniqKey="Huikuri H" first="Heikki V" last="Huikuri">Heikki V. Huikuri</name><affiliation><nlm:aff id="A96">Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="A162">Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Iribarren, Carlos" sort="Iribarren, Carlos" uniqKey="Iribarren C" first="Carlos" last="Iribarren">Carlos Iribarren</name><affiliation><nlm:aff id="A163">Division of Research, Kaiser Permanente of Northern California, Oakland, California, USA</nlm:aff></affiliation></author><author><name sortKey="Isomaa, Bo" sort="Isomaa, Bo" uniqKey="Isomaa B" first="Bo" last="Isomaa">Bo Isomaa</name><affiliation><nlm:aff id="A159">Folkhälsan Research Centre, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A164">Department of Social Services and Health Care, Jakobstad, Finland</nlm:aff></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation><nlm:aff id="A44">Department of Epidemiology and Biostatistics, Imperial College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A45">MRC–Health Protection Agency (MRC-HPA) Centre for Environment and Health, Imperial College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A125">National Institute for Health and Welfare, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A165">Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A166">Institute of Health Sciences, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Jula, Antti" sort="Jula, Antti" uniqKey="Jula A" first="Antti" last="Jula">Antti Jula</name><affiliation><nlm:aff id="A167">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:aff id="A168">Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Kiemeney, Lambertus A" sort="Kiemeney, Lambertus A" uniqKey="Kiemeney L" first="Lambertus A" last="Kiemeney">Lambertus A. Kiemeney</name><affiliation><nlm:aff id="A169">Department for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A170">Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Der Klauw, Melanie M" sort="Van Der Klauw, Melanie M" uniqKey="Van Der Klauw M" first="Melanie M" last="Van Der Klauw">Melanie M. Van Der Klauw</name><affiliation><nlm:aff id="A171">Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S" last="Kooner">Jaspal S. Kooner</name><affiliation><nlm:aff id="A102">Cardiology Department, Ealing Hospital National Health Service (NHS) Trust, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A136">National Heart and Lung Institute, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="A162">Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Iacoviello, Licia" sort="Iacoviello, Licia" uniqKey="Iacoviello L" first="Licia" last="Iacoviello">Licia Iacoviello</name><affiliation><nlm:aff id="A172">Laboratory of Genetic and Environmental Epidemiology, Fondazione di Ricerca e Cura Giovanni Paolo II, Catholic University, Campobasso, Italy</nlm:aff></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:aff id="A168">Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Lokki, Marja Liisa L" sort="Lokki, Marja Liisa L" uniqKey="Lokki M" first="Marja-Liisa L" last="Lokki">Marja-Liisa L. Lokki</name><affiliation><nlm:aff id="A173">transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D" last="Mitchell">Braxton D. Mitchell</name><affiliation><nlm:aff id="A42">Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland, School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name><affiliation><nlm:aff id="A174">Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Nieminen, Markku S" sort="Nieminen, Markku S" uniqKey="Nieminen M" first="Markku S" last="Nieminen">Markku S. Nieminen</name><affiliation><nlm:aff id="A175">Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Ohlsson, Claes" sort="Ohlsson, Claes" uniqKey="Ohlsson C" first="Claes" last="Ohlsson">Claes Ohlsson</name><affiliation><nlm:aff id="A41">Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Poulter, Neil R" sort="Poulter, Neil R" uniqKey="Poulter N" first="Neil R" last="Poulter">Neil R. Poulter</name><affiliation><nlm:aff id="A176">International Centre for Circulatory Health (ICCH), Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Qi, Lu" sort="Qi, Lu" uniqKey="Qi L" first="Lu" last="Qi">Lu Qi</name><affiliation><nlm:aff id="A28">Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Raitakari, Olli T" sort="Raitakari, Olli T" uniqKey="Raitakari O" first="Olli T" last="Raitakari">Olli T. Raitakari</name><affiliation><nlm:aff id="A177">Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A178">Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Rimm, Eric B" sort="Rimm, Eric B" uniqKey="Rimm E" first="Eric B" last="Rimm">Eric B. Rimm</name><affiliation><nlm:aff id="A28">Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Rioux, John D" sort="Rioux, John D" uniqKey="Rioux J" first="John D" last="Rioux">John D. Rioux</name><affiliation><nlm:aff id="A26">Université de Montréal, Montreal, Quebec, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Montreal Heart Institute, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Rizzi, Federica" sort="Rizzi, Federica" uniqKey="Rizzi F" first="Federica" last="Rizzi">Federica Rizzi</name><affiliation><nlm:aff id="A179">Kos Genetic, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="A142">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation><nlm:aff id="A48">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Sever, Peter S" sort="Sever, Peter S" uniqKey="Sever P" first="Peter S" last="Sever">Peter S. Sever</name><affiliation><nlm:aff id="A176">International Centre for Circulatory Health (ICCH), Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Shields, Denis C" sort="Shields, Denis C" uniqKey="Shields D" first="Denis C" last="Shields">Denis C. Shields</name><affiliation><nlm:aff id="A180">Complex and Adaptive Systems Laboratory, University College Dublin, Belfield, Dublin, Ireland</nlm:aff></affiliation><affiliation><nlm:aff id="A181">Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland</nlm:aff></affiliation><affiliation><nlm:aff id="A182">School of Medicine and Medical Sciences, University College Dublin, Belfield, Dublin, Ireland</nlm:aff></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R" last="Shuldiner">Alan R. Shuldiner</name><affiliation><nlm:aff id="A42">Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland, School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A183">Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Sinisalo, Juha" sort="Sinisalo, Juha" uniqKey="Sinisalo J" first="Juha" last="Sinisalo">Juha Sinisalo</name><affiliation><nlm:aff id="A175">Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Stanton, Alice V" sort="Stanton, Alice V" uniqKey="Stanton A" first="Alice V" last="Stanton">Alice V. Stanton</name><affiliation><nlm:aff id="A184">Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland</nlm:aff></affiliation></author><author><name sortKey="Stolk, Ronald P" sort="Stolk, Ronald P" uniqKey="Stolk R" first="Ronald P" last="Stolk">Ronald P. Stolk</name><affiliation><nlm:aff id="A10">Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P" last="Strachan">David P. Strachan</name><affiliation><nlm:aff id="A29">Division of Population Health Sciences and Education, St. George’s, University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Tardif, Jean Claude" sort="Tardif, Jean Claude" uniqKey="Tardif J" first="Jean-Claude" last="Tardif">Jean-Claude Tardif</name><affiliation><nlm:aff id="A26">Université de Montréal, Montreal, Quebec, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Montreal Heart Institute, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation><nlm:aff id="A13">deCODE Genetics, Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A154">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Tuomilehto, Jaako" sort="Tuomilehto, Jaako" uniqKey="Tuomilehto J" first="Jaako" last="Tuomilehto">Jaako Tuomilehto</name><affiliation><nlm:aff id="A185">Diabetes Unit, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A186">Centre for Vascular Prevention, Danube-University Krems, Krems, Austria</nlm:aff></affiliation><affiliation><nlm:aff id="A187">Red Temática de Investigación Cooperativa en Enfermedades Cardiovasculares (Red RECAVA), Grupo RD06/0014/0015, Hospital Universitario La Paz, Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A188">King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Van Veldhuisen, Dirk J" sort="Van Veldhuisen, Dirk J" uniqKey="Van Veldhuisen D" first="Dirk J" last="Van Veldhuisen">Dirk J. Van Veldhuisen</name><affiliation><nlm:aff id="A31">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation><nlm:aff id="A48">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Viikari, Jorma" sort="Viikari, Jorma" uniqKey="Viikari J" first="Jorma" last="Viikari">Jorma Viikari</name><affiliation><nlm:aff id="A189">Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:aff id="A190">Department of Internal Medicine, University Hospital of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Waeber, Gerard" sort="Waeber, Gerard" uniqKey="Waeber G" first="Gérard" last="Waeber">Gérard Waeber</name><affiliation><nlm:aff id="A190">Department of Internal Medicine, University Hospital of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name><affiliation><nlm:aff id="A191">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Cho, Yoon Shin" sort="Cho, Yoon Shin" uniqKey="Cho Y" first="Yoon Shin" last="Cho">Yoon Shin Cho</name><affiliation><nlm:aff id="A192">Department of Biomedical Science, Hallym University, Chuncheon, Korea</nlm:aff></affiliation></author><author><name sortKey="Olsen, Jesper V" sort="Olsen, Jesper V" uniqKey="Olsen J" first="Jesper V" last="Olsen">Jesper V. Olsen</name><affiliation><nlm:aff id="A22">Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Visscher, Peter M" sort="Visscher, Peter M" uniqKey="Visscher P" first="Peter M" last="Visscher">Peter M. Visscher</name><affiliation><nlm:aff id="A193">Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Willer, Cristen" sort="Willer, Cristen" uniqKey="Willer C" first="Cristen" last="Willer">Cristen Willer</name><affiliation><nlm:aff id="A194">Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Franke, Lude" sort="Franke, Lude" uniqKey="Franke L" first="Lude" last="Franke">Lude Franke</name><affiliation><nlm:aff id="A15">Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A195">Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Erdmann, Jeanette" sort="Erdmann, Jeanette" uniqKey="Erdmann J" first="Jeanette" last="Erdmann">Jeanette Erdmann</name><affiliation><nlm:aff id="A90">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck)</nlm:aff></affiliation><affiliation><nlm:aff id="A197">Institute for Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A198">DZHK, partner site Hamburg/Kiel/Lübeck, Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Thompson, John R" sort="Thompson, John R" uniqKey="Thompson J" first="John R" last="Thompson">John R. Thompson</name><affiliation><nlm:aff id="A199">Department of Health Sciences, University of Leicester, Leicester, UK</nlm:aff></affiliation></author><author><name sortKey="Pfeufer, Arne" sort="Pfeufer, Arne" uniqKey="Pfeufer A" first="Arne" last="Pfeufer">Arne Pfeufer</name><affiliation><nlm:aff id="A200">Institute of Human Genetics, Helmholtz Zentrum München–german Research Center for Environmental Health, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A201">Institute of Human Genetics, Klinikum Rechts der Isar der Technischen Universitat München, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Sotoodehnia, Nona" sort="Sotoodehnia, Nona" uniqKey="Sotoodehnia N" first="Nona" last="Sotoodehnia">Nona Sotoodehnia</name><affiliation><nlm:aff id="A71">Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A202">Department of Medicine, Division of Cardiology, University of Washington School of Medicine, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Newton Cheh, Christopher" sort="Newton Cheh, Christopher" uniqKey="Newton Cheh C" first="Christopher" last="Newton-Cheh">Christopher Newton-Cheh</name><affiliation><nlm:aff id="A12">Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A110">National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A203">Center for Human Genetic Research, Cardiovacular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Ellinor, Patrick T" sort="Ellinor, Patrick T" uniqKey="Ellinor P" first="Patrick T" last="Ellinor">Patrick T. Ellinor</name><affiliation><nlm:aff id="A62">Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A204">Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A205">Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Stricker, Bruno H Ch" sort="Stricker, Bruno H Ch" uniqKey="Stricker B" first="Bruno H Ch" last="Stricker">Bruno H Ch Stricker</name><affiliation><nlm:aff id="A3">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Ageing, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A103">Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A140">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A206">Inspectorate of Health Care, The Hague, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation><nlm:aff id="A4">Estonian Biocenter, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name><affiliation><nlm:aff id="A5">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A39">The Institute of Molecular Medicine, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Jacques S" sort="Beckmann, Jacques S" uniqKey="Beckmann J" first="Jacques S" last="Beckmann">Jacques S. Beckmann</name><affiliation><nlm:aff id="A37">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A207">Service of Medical Genetics, CHUV University Hospital, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><affiliation><nlm:aff id="A9">MRC Centre for Causal Analyses in Translational Epidemiology (CAiTE), School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><nlm:aff id="A13">deCODE Genetics, Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A154">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A1">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Munroe, Patricia B" sort="Munroe, Patricia B" uniqKey="Munroe P" first="Patricia B" last="Munroe">Patricia B. Munroe</name><affiliation><nlm:aff id="A16">Clinical Pharmacology, National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Sibon, Ody C M" sort="Sibon, Ody C M" uniqKey="Sibon O" first="Ody C M" last="Sibon">Ody C M. Sibon</name><affiliation><nlm:aff id="A99">Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Milan, David J" sort="Milan, David J" uniqKey="Milan D" first="David J" last="Milan">David J. Milan</name><affiliation><nlm:aff id="A8">Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A208">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation><nlm:aff id="A10">Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J" last="Samani">Nilesh J. Samani</name><affiliation><nlm:aff id="A209">Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A210">NIHR Leicester Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, UK</nlm:aff></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J F" last="Loos">Ruth J F. Loos</name><affiliation><nlm:aff id="A1">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A211">The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A212">The Charles Bronfman Institute of Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A213">The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci. Experimental downregulation of gene expression in <italic>Drosophila melanogaster</italic> and <italic>Danio rerio</italic> identified 20 genes at 11 loci that are relevant for heart rate regulation and highlight a role for genes involved in signal transmission, embryonic cardiac development and the pathophysiology of dilated cardiomyopathy, congenital heart failure and/or sudden cardiac death. In addition, genetic susceptibility to increased heart rate is associated with altered cardiac conduction and reduced risk of sick sinus syndrome, and both heart rate–increasing and heart rate–decreasing variants associate with risk of atrial fibrillation. Our findings provide fresh insights into the mechanisms regulating heart rate and identify new therapeutic targets.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id><journal-id journal-id-type="pubmed-jr-id">2419</journal-id><journal-id journal-id-type="nlm-ta">Nat Genet</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Genet.</journal-id><journal-title-group><journal-title>Nature genetics</journal-title></journal-title-group><issn pub-type="ppub">1061-4036</issn><issn pub-type="epub">1546-1718</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23583979</article-id><article-id pub-id-type="pmc">3696959</article-id><article-id pub-id-type="doi">10.1038/ng.2610</article-id><article-id pub-id-type="manuscript">NIHMS473857</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>den Hoed</surname><given-names>Marcel</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib 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rid="A154">154</xref></contrib><contrib contrib-type="author"><name><surname>Wareham</surname><given-names>Nicholas J</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Munroe</surname><given-names>Patricia B</given-names></name><xref ref-type="aff" rid="A16">16</xref><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Sibon</surname><given-names>Ody C M</given-names></name><xref ref-type="aff" rid="A99">99</xref></contrib><contrib contrib-type="author"><name><surname>Milan</surname><given-names>David J</given-names></name><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A208">208</xref></contrib><contrib contrib-type="author"><name><surname>Snieder</surname><given-names>Harold</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Samani</surname><given-names>Nilesh J</given-names></name><xref ref-type="aff" rid="A209">209</xref><xref ref-type="aff" rid="A210">210</xref></contrib><contrib contrib-type="author"><name><surname>Loos</surname><given-names>Ruth J F</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A211">211</xref><xref ref-type="aff" rid="A212">212</xref><xref ref-type="aff" rid="A213">213</xref></contrib></contrib-group><aff id="A1"><label>1</label>Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</aff><aff id="A2"><label>2</label>Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden</aff><aff id="A3"><label>3</label>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A4"><label>4</label>Estonian Biocenter, Tartu, Estonia</aff><aff id="A5"><label>5</label>Estonian Genome Center, University of Tartu, Tartu, Estonia</aff><aff id="A6"><label>6</label>Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</aff><aff id="A7"><label>7</label>Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A8"><label>8</label>Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA</aff><aff id="A9"><label>9</label>MRC Centre for Causal Analyses in Translational Epidemiology (CAiTE), School of Social and Community Medicine, University of Bristol, Bristol, UK</aff><aff id="A10"><label>10</label>Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A11"><label>11</label>Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA</aff><aff id="A12"><label>12</label>Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA</aff><aff id="A13"><label>13</label>deCODE Genetics, Reykjavik, Iceland</aff><aff id="A14"><label>14</label>Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA</aff><aff id="A15"><label>15</label>Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A16"><label>16</label>Clinical Pharmacology, National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</aff><aff id="A17"><label>17</label>Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</aff><aff id="A18"><label>18</label>Centre for Medical Systems Biology, Leiden, The Netherlands</aff><aff id="A19"><label>19</label>Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK</aff><aff id="A20"><label>20</label>Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA</aff><aff id="A21"><label>21</label>The Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark</aff><aff id="A22"><label>22</label>Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark</aff><aff id="A23"><label>23</label>Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Daejeon, The Republic of Korea</aff><aff id="A24"><label>24</label>Department of Clinical Sciences, Diabetes and Endocrinology, Lund University and Lund University Diabetes Centre, Malmö, Sweden</aff><aff id="A25"><label>25</label>Community Prevention Unit, Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland</aff><aff id="A26"><label>26</label>Université de Montréal, Montreal, Quebec, Canada</aff><aff id="A27"><label>27</label>Montreal Heart Institute, Montreal, Quebec, Canada</aff><aff id="A28"><label>28</label>Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</aff><aff id="A29"><label>29</label>Division of Population Health Sciences and Education, St. George’s, University of London, London, UK</aff><aff id="A30"><label>30</label>Pediatric Epidemiology Center, University of South Florida, Tampa, Florida, USA</aff><aff id="A31"><label>31</label>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A32"><label>32</label>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</aff><aff id="A33"><label>33</label>Department of Internal Medicine, VU Medical Center, Amsterdam, The Netherlands</aff><aff id="A34"><label>34</label>Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</aff><aff id="A35"><label>35</label>Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA</aff><aff id="A36"><label>36</label>Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA</aff><aff id="A37"><label>37</label>Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland</aff><aff id="A38"><label>38</label>Swiss Institute of Bioinformatics, Lausanne, Switzerland</aff><aff id="A39"><label>39</label>The Institute of Molecular Medicine, University of Helsinki, Helsinki, Finland</aff><aff id="A40"><label>40</label>Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland</aff><aff id="A41"><label>41</label>Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden</aff><aff id="A42"><label>42</label>Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland, School of Medicine, Baltimore, Maryland, USA</aff><aff id="A43"><label>43</label>Department of Medicine, Institute for Human Genetics, University of California, San Francisco, San Francisco, California, USA</aff><aff id="A44"><label>44</label>Department of Epidemiology and Biostatistics, Imperial College London, London, UK</aff><aff id="A45"><label>45</label>MRC–Health Protection Agency (MRC-HPA) Centre for Environment and Health, Imperial College London, London, UK</aff><aff id="A46"><label>46</label>Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK</aff><aff id="A47"><label>47</label>Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA</aff><aff id="A48"><label>48</label>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</aff><aff id="A49"><label>49</label>Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA</aff><aff id="A50"><label>50</label>HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA</aff><aff id="A51"><label>51</label>Information Management Services, Inc., Rockville, Maryland, USA</aff><aff id="A52"><label>52</label>Department of Biological Psychology, VU University Amsterdam and Institute for Health and Care Research (EMGO+), VU Medical Center, Amsterdam, The Netherlands</aff><aff id="A53"><label>53</label>Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, USA</aff><aff id="A54"><label>54</label>Department of Biostatistics, University of Washington, Seattle, Washington, USA</aff><aff id="A55"><label>55</label>Quantitative Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia</aff><aff id="A56"><label>56</label>Complex Genetics Section, Department of Medical Genetics–de Bakker Group, University Medical Center Utrecht, Utrecht, The Netherlands</aff><aff id="A57"><label>57</label>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands</aff><aff id="A58"><label>58</label>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A59"><label>59</label>Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</aff><aff id="A60"><label>60</label>Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8199, Institut Pasteur de Lille, Lille, France</aff><aff id="A61"><label>61</label>Division of Preventive Medicine, Cardiovascular Division, Brigham and Women’s Hospital, Boston, Massachusetts, USA</aff><aff id="A62"><label>62</label>Harvard Medical School, Boston, Massachusetts, USA</aff><aff id="A63"><label>63</label>Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA</aff><aff id="A64"><label>64</label>Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</aff><aff id="A65"><label>65</label>McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</aff><aff id="A66"><label>66</label>Department of Medicine, Division of Genetics, Brigham and Women’s Hospital, Boston, Massachusetts, USA</aff><aff id="A67"><label>67</label>Department of Medical Genetics, Division of Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</aff><aff id="A68"><label>68</label>Institut National de la Santé et de la Recherche Médicale (INSERM), CESP Centre for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease over The Lifecourse, Villejuif, France</aff><aff id="A69"><label>69</label>UMRS 1018, Université Paris–Sud 11, Villejuif, France</aff><aff id="A70"><label>70</label>Department of Health Sciences, Milan University and Filarete Foundation, Milan, Italy</aff><aff id="A71"><label>71</label>Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA</aff><aff id="A72"><label>72</label>Department of Medicine, University of Washington, Seattle, Washington, USA</aff><aff id="A73"><label>73</label>Lille Nord de France University, Lille, France</aff><aff id="A74"><label>74</label>INSERM U970, Paris Cardiovascular Research Centre, Hopital Européen Georges Pampidou, Paris, France</aff><aff id="A75"><label>75</label>Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, Maryland, USA</aff><aff id="A76"><label>76</label>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, Maryland, USA</aff><aff id="A77"><label>77</label>National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA</aff><aff id="A78"><label>78</label>Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA</aff><aff id="A79"><label>79</label>Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA</aff><aff id="A80"><label>80</label>Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA</aff><aff id="A81"><label>81</label>INSERM U1087, CNRS U6291 and University of Nantes, l’Institut du Thorax, Nantes, France</aff><aff id="A82"><label>82</label>Centre Hospitalier Universitaire (CHU) Nantes, l’Institut du Thorax, Nantes, France</aff><aff id="A83"><label>83</label>Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany</aff><aff id="A84"><label>84</label>DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany</aff><aff id="A85"><label>85</label>Icelandic Heart Association Research Institute, Kopavogur, Iceland</aff><aff id="A86"><label>86</label>University of Iceland, Reykjavik, Iceland</aff><aff id="A87"><label>87</label>Laboratory for Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA</aff><aff id="A88"><label>88</label>Department of Clinical Sciences, Obstetrics and Gynecology, University of Oulu, Oulu, Finland</aff><aff id="A89"><label>89</label>Department of Epidemiology, University of Washington, Seattle, Washington, USA</aff><aff id="A90"><label>90</label>Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck)</aff><aff id="A91"><label>91</label>Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Ageing, Rotterdam, The Netherlands</aff><aff id="A92"><label>92</label>Department of General Internal Medicine, Division of Vascular Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</aff><aff id="A93"><label>93</label>Nyken, Groningen, The Netherlands</aff><aff id="A94"><label>94</label>Uppsala Clinical Research Center, Uppsala University Hospital, Uppsala, Sweden</aff><aff id="A95"><label>95</label>Division of Cardiology, Miller School of Medicine, University of Miami, Miami, Florida, USA</aff><aff id="A96"><label>96</label>Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland</aff><aff id="A97"><label>97</label>Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians- Universität, Munich, Germany</aff><aff id="A98"><label>98</label>Munich Heart Alliance, Munich, Germany</aff><aff id="A99"><label>99</label>Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A100"><label>100</label>Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK</aff><aff id="A101"><label>101</label>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA</aff><aff id="A102"><label>102</label>Cardiology Department, Ealing Hospital National Health Service (NHS) Trust, London, UK</aff><aff id="A103"><label>103</label>Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A104"><label>104</label>Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, London, UK</aff><aff id="A105"><label>105</label>National Public Health Institute, Biomedicum Helsinki, Helsinki, Finland</aff><aff id="A106"><label>106</label>Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, Maryland, USA</aff><aff id="A107"><label>107</label>Division Pharmacoepidemiology & Clinical Pharmacology, Utrecht University, Utrecht, The Netherlands</aff><aff id="A108"><label>108</label>Department of Epidemiology & Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina, USA</aff><aff id="A109"><label>109</label>Department of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts, USA</aff><aff id="A110"><label>110</label>National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA</aff><aff id="A111"><label>111</label>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany</aff><aff id="A112"><label>112</label>Institut Universitaire de Médecine Sociale et Préventive (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland</aff><aff id="A113"><label>113</label>School of Social and Community Medicine, University of Bristol, Bristol, UK</aff><aff id="A114"><label>114</label>Molecular Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia</aff><aff id="A115"><label>115</label>Human Genetics Center, University of Texas Health Science Center, Houston, Texas, USA</aff><aff id="A116"><label>116</label>Chair of Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</aff><aff id="A117"><label>117</label>Institute of Genetic Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="A118"><label>118</label>Department of Medical Genetics and Development, University of Geneva Medical School, Geneva, Switzerland</aff><aff id="A119"><label>119</label>Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA</aff><aff id="A120"><label>120</label>National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA</aff><aff id="A121"><label>121</label>MRC Unit for Lifelong Health and Ageing, London, UK</aff><aff id="A122"><label>122</label>Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</aff><aff id="A123"><label>123</label>Institute of Epidemiology II, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="A124"><label>124</label>Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia</aff><aff id="A125"><label>125</label>National Institute for Health and Welfare, Oulu, Finland</aff><aff id="A126"><label>126</label>Department of Neurology, General Central Hospital, Bolzano, Italy</aff><aff id="A127"><label>127</label>Department of Neurology, University of Lübeck, Lübeck, Germany</aff><aff id="A128"><label>128</label>Group Health Research Institute, Seattle, Washington, USA</aff><aff id="A129"><label>129</label>Department of Health Services, University of Washington, Seattle, Washington, USA</aff><aff id="A130"><label>130</label>Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA</aff><aff id="A131"><label>131</label>Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA</aff><aff id="A132"><label>132</label>Harvard Biological and Biomedical Sciences Program, Harvard University, Boston, Massachusetts, USA</aff><aff id="A133"><label>133</label>Health Science and Technology M.D. Program, Harvard University and Massachusetts Institute of Technology, Boston, Massachusetts, USA</aff><aff id="A134"><label>134</label>Department of Pathophysiology, Faculty of Medicine, University of Split, Split, Croatia</aff><aff id="A135"><label>135</label>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy</aff><aff id="A136"><label>136</label>National Heart and Lung Institute, Imperial College London, London, UK</aff><aff id="A137"><label>137</label>Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA</aff><aff id="A138"><label>138</label>Department of Twin Research and Genetic Epidemiology Unit, St. Thomas’ Campus, King’s College London, St. Thomas’ Hospital, London, UK</aff><aff id="A139"><label>139</label>Biology Department, Boston College, Chestnut Hill, Massachusetts, USA</aff><aff id="A140"><label>140</label>Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</aff><aff id="A141"><label>141</label>genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia</aff><aff id="A142"><label>142</label>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</aff><aff id="A143"><label>143</label>Division of Biomedical Sciences, St. George’s University of London, London, UK</aff><aff id="A144"><label>144</label>Department of Physiatrics, Lapland Central Hospital, Rovaniemi, Finland</aff><aff id="A145"><label>145</label>Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</aff><aff id="A146"><label>146</label>Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway</aff><aff id="A147"><label>147</label>Genomic Medicine, Hammersmith Hospital, Imperial College London, London, UK</aff><aff id="A148"><label>148</label>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</aff><aff id="A149"><label>149</label>Department of Medical Sciences, Uppsala University, Akademiska Sjukhuset, Uppsala, Sweden</aff><aff id="A150"><label>150</label>Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A151"><label>151</label>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</aff><aff id="A152"><label>152</label>Institue of Cellular Medicine, Newcastle University, Newcastle, UK</aff><aff id="A153"><label>153</label>Department of Medicine, Landspitali University Hospital, Reykjavik, Iceland</aff><aff id="A154"><label>154</label>Faculty of Medicine, University of Iceland, Reykjavik, Iceland</aff><aff id="A155"><label>155</label>Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</aff><aff id="A156"><label>156</label>Channing Laboratory and Renal Division, Brigham and Women’s Hospital, Boston, Massachusetts, USA</aff><aff id="A157"><label>157</label>Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA</aff><aff id="A158"><label>158</label>Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland</aff><aff id="A159"><label>159</label>Folkhälsan Research Centre, Helsinki, Finland</aff><aff id="A160"><label>160</label>Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A161"><label>161</label>Hypertension and Related Diseases Centre–Azienda Ospedaliero Universitaria (AOU), University of Sassari, Sassari, Italy</aff><aff id="A162"><label>162</label>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</aff><aff id="A163"><label>163</label>Division of Research, Kaiser Permanente of Northern California, Oakland, California, USA</aff><aff id="A164"><label>164</label>Department of Social Services and Health Care, Jakobstad, Finland</aff><aff id="A165"><label>165</label>Biocenter Oulu, University of Oulu, Oulu, Finland</aff><aff id="A166"><label>166</label>Institute of Health Sciences, University of Oulu, Oulu, Finland</aff><aff id="A167"><label>167</label>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland</aff><aff id="A168"><label>168</label>Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Tampere, Finland</aff><aff id="A169"><label>169</label>Department for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands</aff><aff id="A170"><label>170</label>Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</aff><aff id="A171"><label>171</label>Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A172"><label>172</label>Laboratory of Genetic and Environmental Epidemiology, Fondazione di Ricerca e Cura Giovanni Paolo II, Catholic University, Campobasso, Italy</aff><aff id="A173"><label>173</label>transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland</aff><aff id="A174"><label>174</label>Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A175"><label>175</label>Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A176"><label>176</label>International Centre for Circulatory Health (ICCH), Imperial College London, London, UK</aff><aff id="A177"><label>177</label>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland</aff><aff id="A178"><label>178</label>Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland</aff><aff id="A179"><label>179</label>Kos Genetic, Milan, Italy</aff><aff id="A180"><label>180</label>Complex and Adaptive Systems Laboratory, University College Dublin, Belfield, Dublin, Ireland</aff><aff id="A181"><label>181</label>Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland</aff><aff id="A182"><label>182</label>School of Medicine and Medical Sciences, University College Dublin, Belfield, Dublin, Ireland</aff><aff id="A183"><label>183</label>Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland, USA</aff><aff id="A184"><label>184</label>Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland</aff><aff id="A185"><label>185</label>Diabetes Unit, National Institute for Health and Welfare, Helsinki, Finland</aff><aff id="A186"><label>186</label>Centre for Vascular Prevention, Danube-University Krems, Krems, Austria</aff><aff id="A187"><label>187</label>Red Temática de Investigación Cooperativa en Enfermedades Cardiovasculares (Red RECAVA), Grupo RD06/0014/0015, Hospital Universitario La Paz, Madrid, Spain</aff><aff id="A188"><label>188</label>King Abdulaziz University, Jeddah, Saudi Arabia</aff><aff id="A189"><label>189</label>Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland</aff><aff id="A190"><label>190</label>Department of Internal Medicine, University Hospital of Lausanne, Lausanne, Switzerland</aff><aff id="A191"><label>191</label>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland</aff><aff id="A192"><label>192</label>Department of Biomedical Science, Hallym University, Chuncheon, Korea</aff><aff id="A193"><label>193</label>Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia</aff><aff id="A194"><label>194</label>Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA</aff><aff id="A195"><label>195</label>Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</aff><aff id="A196"><label>196</label>A full list of members appears in the<xref rid="SD1" ref-type="supplementary-material">Supplementary Note</xref></aff><aff id="A197"><label>197</label>Institute for Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany</aff><aff id="A198"><label>198</label>DZHK, partner site Hamburg/Kiel/Lübeck, Lübeck, Germany</aff><aff id="A199"><label>199</label>Department of Health Sciences, University of Leicester, Leicester, UK</aff><aff id="A200"><label>200</label>Institute of Human Genetics, Helmholtz Zentrum München–german Research Center for Environmental Health, Munich, Germany</aff><aff id="A201"><label>201</label>Institute of Human Genetics, Klinikum Rechts der Isar der Technischen Universitat München, Munich, Germany</aff><aff id="A202"><label>202</label>Department of Medicine, Division of Cardiology, University of Washington School of Medicine, Seattle, Washington, USA</aff><aff id="A203"><label>203</label>Center for Human Genetic Research, Cardiovacular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA</aff><aff id="A204"><label>204</label>Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, Massachusetts, USA</aff><aff id="A205"><label>205</label>Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA</aff><aff id="A206"><label>206</label>Inspectorate of Health Care, The Hague, The Netherlands</aff><aff id="A207"><label>207</label>Service of Medical Genetics, CHUV University Hospital, Lausanne, Switzerland</aff><aff id="A208"><label>208</label>Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA</aff><aff id="A209"><label>209</label>Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK</aff><aff id="A210"><label>210</label>NIHR Leicester Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, UK</aff><aff id="A211"><label>211</label>The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, USA</aff><aff id="A212"><label>212</label>The Charles Bronfman Institute of Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, USA</aff><aff id="A213"><label>213</label>The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York, USA</aff><author-notes><corresp id="FN1">Correspondence should be addressed to R.J.F.L. (<email>ruth.loos@mssm.edu</email>)</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>17</day><month>5</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>14</day><month>4</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>6</month><year>2014</year></pub-date><volume>45</volume><issue>6</issue><fpage>621</fpage><lpage>631</lpage><pmc-comment>elocation-id from pubmed: 10.1038/ng.2610</pmc-comment>
<permissions><copyright-statement>© 2013 Nature America, Inc. All rights reserved.</copyright-statement><copyright-year>2013</copyright-year></permissions><abstract><p id="P1">Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci. Experimental downregulation of gene expression in <italic>Drosophila melanogaster</italic> and <italic>Danio rerio</italic> identified 20 genes at 11 loci that are relevant for heart rate regulation and highlight a role for genes involved in signal transmission, embryonic cardiac development and the pathophysiology of dilated cardiomyopathy, congenital heart failure and/or sudden cardiac death. In addition, genetic susceptibility to increased heart rate is associated with altered cardiac conduction and reduced risk of sick sinus syndrome, and both heart rate–increasing and heart rate–decreasing variants associate with risk of atrial fibrillation. Our findings provide fresh insights into the mechanisms regulating heart rate and identify new therapeutic targets.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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