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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genome-wide association analyses identify 18 new loci associated with serum urate concentrations</title><author><name sortKey="Kottgen, Anna" sort="Kottgen, Anna" uniqKey="Kottgen A" first="Anna" last="Köttgen">Anna Köttgen</name><affiliation><nlm:aff id="A1">Renal Division, Freiburg University Hospital, Freiburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Albrecht, Eva" sort="Albrecht, Eva" uniqKey="Albrecht E" first="Eva" last="Albrecht">Eva Albrecht</name><affiliation><nlm:aff id="A3">Institute of Genetic Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:aff id="A4">Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation><nlm:aff id="A5">Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Krumsiek, Jan" sort="Krumsiek, Jan" uniqKey="Krumsiek J" first="Jan" last="Krumsiek">Jan Krumsiek</name><affiliation><nlm:aff id="A6">Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hundertmark, Claudia" sort="Hundertmark, Claudia" uniqKey="Hundertmark C" first="Claudia" last="Hundertmark">Claudia Hundertmark</name><affiliation><nlm:aff id="A1">Renal Division, Freiburg University Hospital, Freiburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Pistis, Giorgio" sort="Pistis, Giorgio" uniqKey="Pistis G" first="Giorgio" last="Pistis">Giorgio Pistis</name><affiliation><nlm:aff id="A7">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Ruggiero, Daniela" sort="Ruggiero, Daniela" uniqKey="Ruggiero D" first="Daniela" last="Ruggiero">Daniela Ruggiero</name><affiliation><nlm:aff id="A8">Institute of Genetics and Biophysics A. Buzzati-Traverso, Consiglio Nazionale delle Ricerche (CNR), Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="O Eaghdha, Conall M" sort="O Eaghdha, Conall M" uniqKey="O Eaghdha C" first="Conall M" last="O Eaghdha">Conall M. O Eaghdha</name><affiliation><nlm:aff id="A9">National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A10">National Heart, Lung, and Blood Institute’s Center for Population Studies, Framingham, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Renal Division, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Haller, Toomas" sort="Haller, Toomas" uniqKey="Haller T" first="Toomas" last="Haller">Toomas Haller</name><affiliation><nlm:aff id="A12">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name><affiliation><nlm:aff id="A9">National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A10">National Heart, Lung, and Blood Institute’s Center for Population Studies, Framingham, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Department of Biostatistics, Boston University, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation><nlm:aff id="A14">Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D" last="Johnson">Andrew D. Johnson</name><affiliation><nlm:aff id="A9">National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A10">National Heart, Lung, and Blood Institute’s Center for Population Studies, Framingham, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name><affiliation><nlm:aff id="A15">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Swiss Institute of Bioinformatics, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V" last="Smith">Albert V. Smith</name><affiliation><nlm:aff id="A17">Icelandic Heart Association Research Institute, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Shi, Julia" sort="Shi, Julia" uniqKey="Shi J" first="Julia" last="Shi">Julia Shi</name><affiliation><nlm:aff id="A19">University of Maryland School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name><affiliation><nlm:aff id="A20">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Middelberg, Rita P S" sort="Middelberg, Rita P S" uniqKey="Middelberg R" first="Rita P S" last="Middelberg">Rita P S. Middelberg</name><affiliation><nlm:aff id="A21">Department of Medicine, Prince Charles Hospital, Chermside, Queensland, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Brown, Morris J" sort="Brown, Morris J" uniqKey="Brown M" first="Morris J" last="Brown">Morris J. Brown</name><affiliation><nlm:aff id="A23">Clinical Pharmacology Unit, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Gaffo, Angelo L" sort="Gaffo, Angelo L" uniqKey="Gaffo A" first="Angelo L" last="Gaffo">Angelo L. Gaffo</name><affiliation><nlm:aff id="A24">Division of Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A25">Birmingham Veterans Affairs Medical Center, University of Alabama at Birmingham, Birmingham, Alabama, USA</nlm:aff></affiliation></author><author><name sortKey="Pirastu, Nicola" sort="Pirastu, Nicola" uniqKey="Pirastu N" first="Nicola" last="Pirastu">Nicola Pirastu</name><affiliation><nlm:aff id="A26">Institute for Maternal and Child Health, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Burlo Garofolo–Trieste, University of Trieste, Trieste, Italy</nlm:aff></affiliation></author><author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name><affiliation><nlm:aff id="A27">Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="A5">Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Zemunik, Tatijana" sort="Zemunik, Tatijana" uniqKey="Zemunik T" first="Tatijana" last="Zemunik">Tatijana Zemunik</name><affiliation><nlm:aff id="A28">Faculty of Medicine, University of Split, Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Huffman, Jennifer" sort="Huffman, Jennifer" uniqKey="Huffman J" first="Jennifer" last="Huffman">Jennifer Huffman</name><affiliation><nlm:aff id="A5">Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Yengo, Loic" sort="Yengo, Loic" uniqKey="Yengo L" first="Loic" last="Yengo">Loic Yengo</name><affiliation><nlm:aff id="A29">Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8199, Genomics and Molecular Physiology of Metabolic Diseases, Institut Pasteur de Lille, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A30">CNRS UMR 8524, Laboratory of Mathematics, University Lille 1, Model for Data Analysis and Learning (MODAL) Team, Institut National de Recherche en Informatique et en Automatique (INRIA) Lille Nord–Europe, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="A31">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Demirkan, Ayse" sort="Demirkan, Ayse" uniqKey="Demirkan A" first="Ayse" last="Demirkan">Ayse Demirkan</name><affiliation><nlm:aff id="A32">Subdivision of Genetic Epidemiology, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Feitosa, Mary F" sort="Feitosa, Mary F" uniqKey="Feitosa M" first="Mary F" last="Feitosa">Mary F. Feitosa</name><affiliation><nlm:aff id="A33">Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="Liu, Xuan" sort="Liu, Xuan" uniqKey="Liu X" first="Xuan" last="Liu">Xuan Liu</name><affiliation><nlm:aff id="A13">Department of Biostatistics, Boston University, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Malerba, Giovanni" sort="Malerba, Giovanni" uniqKey="Malerba G" first="Giovanni" last="Malerba">Giovanni Malerba</name><affiliation><nlm:aff id="A34">Biology and Genetics Section, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy</nlm:aff></affiliation></author><author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M" last="Lopez">Lorna M. Lopez</name><affiliation><nlm:aff id="A35">Department of Psychology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation><nlm:aff id="A37">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Li, Xinzhong" sort="Li, Xinzhong" uniqKey="Li X" first="Xinzhong" last="Li">Xinzhong Li</name><affiliation><nlm:aff id="A38">Institute of Clinical Science, Faculty of Medicine, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E" last="Kleber">Marcus E. Kleber</name><affiliation><nlm:aff id="A39">Ludwigshafen Risk and Cardiovascular Health (LURIC) Study, Freiburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A" last="Hicks">Andrew A. Hicks</name><affiliation><nlm:aff id="A41">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck)</nlm:aff></affiliation></author><author><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M" last="Nolte">Ilja M. Nolte</name><affiliation><nlm:aff id="A42">Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Johansson, Asa" sort="Johansson, Asa" uniqKey="Johansson A" first="Asa" last="Johansson">Asa Johansson</name><affiliation><nlm:aff id="A43">Uppsala Clinical Research Center, Uppsala University Hospital, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A44">Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Murgia, Federico" sort="Murgia, Federico" uniqKey="Murgia F" first="Federico" last="Murgia">Federico Murgia</name><affiliation><nlm:aff id="A45">Institute of Population Genetics, CNR, Sassari, Italy</nlm:aff></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H" last="Wild">Sarah H. Wild</name><affiliation><nlm:aff id="A46">Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Bakker, Stephan J L" sort="Bakker, Stephan J L" uniqKey="Bakker S" first="Stephan J L" last="Bakker">Stephan J L. Bakker</name><affiliation><nlm:aff id="A47">Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Peden, John F" sort="Peden, John F" uniqKey="Peden J" first="John F" last="Peden">John F. Peden</name><affiliation><nlm:aff id="A48">Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name><affiliation><nlm:aff id="A20">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Member of Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Steri, Maristella" sort="Steri, Maristella" uniqKey="Steri M" first="Maristella" last="Steri">Maristella Steri</name><affiliation><nlm:aff id="A50">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Italy</nlm:aff></affiliation></author><author><name sortKey="Tenesa, Albert" sort="Tenesa, Albert" uniqKey="Tenesa A" first="Albert" last="Tenesa">Albert Tenesa</name><affiliation><nlm:aff id="A5">Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A51">Roslin Institute, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Lagou, Vasiliki" sort="Lagou, Vasiliki" uniqKey="Lagou V" first="Vasiliki" last="Lagou">Vasiliki Lagou</name><affiliation><nlm:aff id="A52">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A53">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Salo, Perttu" sort="Salo, Perttu" uniqKey="Salo P" first="Perttu" last="Salo">Perttu Salo</name><affiliation><nlm:aff id="A54">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation><nlm:aff id="A55">King’s College London, St Thomas’ Hospital Campus, London, UK</nlm:aff></affiliation></author><author><name sortKey="Rose, Lynda M" sort="Rose, Lynda M" uniqKey="Rose L" first="Lynda M" last="Rose">Lynda M. Rose</name><affiliation><nlm:aff id="A56">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:aff id="A57">Fimlab Laboratories, University of Tampere and Tampere University Hospital, Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Woodward, Owen M" sort="Woodward, Owen M" uniqKey="Woodward O" first="Owen M" last="Woodward">Owen M. Woodward</name><affiliation><nlm:aff id="A58">Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Okada, Yukinori" sort="Okada, Yukinori" uniqKey="Okada Y" first="Yukinori" last="Okada">Yukinori Okada</name><affiliation><nlm:aff id="A59">Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, Tokyo, Japan</nlm:aff></affiliation><affiliation><nlm:aff id="A60">Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Tin, Adrienne" sort="Tin, Adrienne" uniqKey="Tin A" first="Adrienne" last="Tin">Adrienne Tin</name><affiliation><nlm:aff id="A2">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Muller, Christian" sort="Muller, Christian" uniqKey="Muller C" first="Christian" last="Müller">Christian Müller</name><affiliation><nlm:aff id="A61">University Heart Center Hamburg, Clinic for General and Interventional Cardiology, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Oldmeadow, Christopher" sort="Oldmeadow, Christopher" uniqKey="Oldmeadow C" first="Christopher" last="Oldmeadow">Christopher Oldmeadow</name><affiliation><nlm:aff id="A62">School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia</nlm:aff></affiliation></author><author><name sortKey="Putku, Margus" sort="Putku, Margus" uniqKey="Putku M" first="Margus" last="Putku">Margus Putku</name><affiliation><nlm:aff id="A63">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Czamara, Darina" sort="Czamara, Darina" uniqKey="Czamara D" first="Darina" last="Czamara">Darina Czamara</name><affiliation><nlm:aff id="A64">Max Planck Institute of Psychiatry, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="A65">Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Frogheri, Laura" sort="Frogheri, Laura" uniqKey="Frogheri L" first="Laura" last="Frogheri">Laura Frogheri</name><affiliation><nlm:aff id="A45">Institute of Population Genetics, CNR, Sassari, Italy</nlm:aff></affiliation></author><author><name sortKey="Thun, Gian Andri" sort="Thun, Gian Andri" uniqKey="Thun G" first="Gian Andri" last="Thun">Gian Andri Thun</name><affiliation><nlm:aff id="A66">Swiss Tropical and Public Health Institute, Basel, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A67">University of Basel, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Grotevendt, Anne" sort="Grotevendt, Anne" uniqKey="Grotevendt A" first="Anne" last="Grotevendt">Anne Grotevendt</name><affiliation><nlm:aff id="A68">Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Gislason, Gauti Kjartan" sort="Gislason, Gauti Kjartan" uniqKey="Gislason G" first="Gauti Kjartan" last="Gislason">Gauti Kjartan Gislason</name><affiliation><nlm:aff id="A17">Icelandic Heart Association Research Institute, Kopavogur, Iceland</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="A69">Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><affiliation><nlm:aff id="A69">Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Mcardle, Patrick" sort="Mcardle, Patrick" uniqKey="Mcardle P" first="Patrick" last="Mcardle">Patrick Mcardle</name><affiliation><nlm:aff id="A19">University of Maryland School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R" last="Shuldiner">Alan R. Shuldiner</name><affiliation><nlm:aff id="A19">University of Maryland School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation><nlm:aff id="A70">University of Texas Health Science Center at Houston, Houston, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Coresh, Josef" sort="Coresh, Josef" uniqKey="Coresh J" first="Josef" last="Coresh">Josef Coresh</name><affiliation><nlm:aff id="A2">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A71">Welch Center for Prevention, Epidemiology and Clinical Research, John Hopkins University, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation><nlm:aff id="A72">Institute of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Schallert, Michael" sort="Schallert, Michael" uniqKey="Schallert M" first="Michael" last="Schallert">Michael Schallert</name><affiliation><nlm:aff id="A73">Department of Neurology, Section of Special Neurology, Medical University Graz, Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="A22">Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W" last="Montgomery">Grant W. Montgomery</name><affiliation><nlm:aff id="A22">Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Kubo, Michiaki" sort="Kubo, Michiaki" uniqKey="Kubo M" first="Michiaki" last="Kubo">Michiaki Kubo</name><affiliation><nlm:aff id="A74">Laboratory for Genotyping Development, Center for Genomic Medicine, RIKEN, Yokohama, Japan</nlm:aff></affiliation></author><author><name sortKey="Nakamura, Yusuke" sort="Nakamura, Yusuke" uniqKey="Nakamura Y" first="Yusuke" last="Nakamura">Yusuke Nakamura</name><affiliation><nlm:aff id="A75">Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Tanaka, Toshihiro" sort="Tanaka, Toshihiro" uniqKey="Tanaka T" first="Toshihiro" last="Tanaka">Toshihiro Tanaka</name><affiliation><nlm:aff id="A76">Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan</nlm:aff></affiliation></author><author><name sortKey="Munroe, Patricia B" sort="Munroe, Patricia B" uniqKey="Munroe P" first="Patricia B" last="Munroe">Patricia B. Munroe</name><affiliation><nlm:aff id="A77">William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J" last="Samani">Nilesh J. Samani</name><affiliation><nlm:aff id="A78">Leicester National Institute for Health Research (NIHR) Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A79">Department of Cardiovascular Sciences, University of Leicester, Leicester, UK</nlm:aff></affiliation></author><author><name sortKey="Jacobs, David R" sort="Jacobs, David R" uniqKey="Jacobs D" first="David R" last="Jacobs">David R. Jacobs</name><affiliation><nlm:aff id="A80">Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Liu, Kiang" sort="Liu, Kiang" uniqKey="Liu K" first="Kiang" last="Liu">Kiang Liu</name><affiliation><nlm:aff id="A81">Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA</nlm:aff></affiliation></author><author><name sortKey="D Damo, Pio" sort="D Damo, Pio" uniqKey="D Damo P" first="Pio" last="D Damo">Pio D Damo</name><affiliation><nlm:aff id="A26">Institute for Maternal and Child Health, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Burlo Garofolo–Trieste, University of Trieste, Trieste, Italy</nlm:aff></affiliation></author><author><name sortKey="Ulivi, Sheila" sort="Ulivi, Sheila" uniqKey="Ulivi S" first="Sheila" last="Ulivi">Sheila Ulivi</name><affiliation><nlm:aff id="A82">Intitute for Maternal and Child Health, IRCCS Burlo Garofolo–Trieste, Trieste, Italy</nlm:aff></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I" last="Rotter">Jerome I. Rotter</name><affiliation><nlm:aff id="A83">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name><affiliation><nlm:aff id="A27">Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A84">Department of Epidemiology, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A85">Department of Medicine, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A86">Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Department of Health Services, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:aff id="A88">Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Waeber, Gerard" sort="Waeber, Gerard" uniqKey="Waeber G" first="Gerard" last="Waeber">Gerard Waeber</name><affiliation><nlm:aff id="A88">Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Campbell, Susan" sort="Campbell, Susan" uniqKey="Campbell S" first="Susan" last="Campbell">Susan Campbell</name><affiliation><nlm:aff id="A5">Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Devuyst, Olivier" sort="Devuyst, Olivier" uniqKey="Devuyst O" first="Olivier" last="Devuyst">Olivier Devuyst</name><affiliation><nlm:aff id="A89">Institute of Physiology, Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Navarro, Pau" sort="Navarro, Pau" uniqKey="Navarro P" first="Pau" last="Navarro">Pau Navarro</name><affiliation><nlm:aff id="A5">Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name><affiliation><nlm:aff id="A28">Faculty of Medicine, University of Split, Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Hastie, Nicholas" sort="Hastie, Nicholas" uniqKey="Hastie N" first="Nicholas" last="Hastie">Nicholas Hastie</name><affiliation><nlm:aff id="A5">Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><affiliation><nlm:aff id="A90">Unité Mixte de Recherche en Santé (UMRS) 1018, University Paris Sud 11, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="A29">Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8199, Genomics and Molecular Physiology of Metabolic Diseases, Institut Pasteur de Lille, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation><nlm:aff id="A12">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A63">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Salumets, Andres" sort="Salumets, Andres" uniqKey="Salumets A" first="Andres" last="Salumets">Andres Salumets</name><affiliation><nlm:aff id="A12">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A92">Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A93">Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay Tee" last="Khaw">Kay Tee Khaw</name><affiliation><nlm:aff id="A94">Clinical Gerontology Unit, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation><nlm:aff id="A31">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A31">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name><affiliation><nlm:aff id="A32">Subdivision of Genetic Epidemiology, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kraja, Aldi" sort="Kraja, Aldi" uniqKey="Kraja A" first="Aldi" last="Kraja">Aldi Kraja</name><affiliation><nlm:aff id="A33">Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="Zhang, Qunyuan" sort="Zhang, Qunyuan" uniqKey="Zhang Q" first="Qunyuan" last="Zhang">Qunyuan Zhang</name><affiliation><nlm:aff id="A33">Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="Wild, Philipp S" sort="Wild, Philipp S" uniqKey="Wild P" first="Philipp S" last="Wild">Philipp S. Wild</name><affiliation><nlm:aff id="A95">Center for Thrombosis and Hemostasis, University Medical Center Mainz, Johannes Gutenberg University Mainz, Mainz, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A96">Department of Medicine II, University Medical Center Mainz, Johannes Gutenberg University Mainz, Mainz, Germany</nlm:aff></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J" last="Scott">Rodney J. Scott</name><affiliation><nlm:aff id="A97">School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia</nlm:aff></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G" last="Holliday">Elizabeth G. Holliday</name><affiliation><nlm:aff id="A62">School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia</nlm:aff></affiliation></author><author><name sortKey="Org, Elin" sort="Org, Elin" uniqKey="Org E" first="Elin" last="Org">Elin Org</name><affiliation><nlm:aff id="A63">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Viigimaa, Margus" sort="Viigimaa, Margus" uniqKey="Viigimaa M" first="Margus" last="Viigimaa">Margus Viigimaa</name><affiliation><nlm:aff id="A98">Chair of Medical Physics, Department of Biomedical Engineering, Tallinn University of Technology, Tallinn, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A99">Centre of Cardiology, North Estonia Medical Centre, Tallinn, Estonia</nlm:aff></affiliation></author><author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name><affiliation><nlm:aff id="A100">Geniatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Metter, Jeffrey E" sort="Metter, Jeffrey E" uniqKey="Metter J" first="Jeffrey E" last="Metter">Jeffrey E. Metter</name><affiliation><nlm:aff id="A14">Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Lupo, Antonio" sort="Lupo, Antonio" uniqKey="Lupo A" first="Antonio" last="Lupo">Antonio Lupo</name><affiliation><nlm:aff id="A101">Division of Nephrology, Department of Medicine, University of Verona, Verona, Italy</nlm:aff></affiliation></author><author><name sortKey="Trabetti, Elisabetta" sort="Trabetti, Elisabetta" uniqKey="Trabetti E" first="Elisabetta" last="Trabetti">Elisabetta Trabetti</name><affiliation><nlm:aff id="A34">Biology and Genetics Section, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy</nlm:aff></affiliation></author><author><name sortKey="Sorice, Rossella" sort="Sorice, Rossella" uniqKey="Sorice R" first="Rossella" last="Sorice">Rossella Sorice</name><affiliation><nlm:aff id="A8">Institute of Genetics and Biophysics A. Buzzati-Traverso, Consiglio Nazionale delle Ricerche (CNR), Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Doring, Angela" sort="Doring, Angela" uniqKey="Doring A" first="Angela" last="Döring">Angela Döring</name><affiliation><nlm:aff id="A102">Institute of Epidemiology II, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A103">Institute of Epidemiology I, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Lattka, Eva" sort="Lattka, Eva" uniqKey="Lattka E" first="Eva" last="Lattka">Eva Lattka</name><affiliation><nlm:aff id="A104">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Strauch, Konstantin" sort="Strauch, Konstantin" uniqKey="Strauch K" first="Konstantin" last="Strauch">Konstantin Strauch</name><affiliation><nlm:aff id="A3">Institute of Genetic Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A105">Chair of Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Theis, Fabian" sort="Theis, Fabian" uniqKey="Theis F" first="Fabian" last="Theis">Fabian Theis</name><affiliation><nlm:aff id="A6">Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Waldenberger, Melanie" sort="Waldenberger, Melanie" uniqKey="Waldenberger M" first="Melanie" last="Waldenberger">Melanie Waldenberger</name><affiliation><nlm:aff id="A104">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H-Erich" last="Wichmann">H-Erich Wichmann</name><affiliation><nlm:aff id="A103">Institute of Epidemiology I, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A106">Chair of Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A107">Klinikum Grosshadern, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Davies, Gail" sort="Davies, Gail" uniqKey="Davies G" first="Gail" last="Davies">Gail Davies</name><affiliation><nlm:aff id="A35">Department of Psychology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Gow, Alan J" sort="Gow, Alan J" uniqKey="Gow A" first="Alan J" last="Gow">Alan J. Gow</name><affiliation><nlm:aff id="A35">Department of Psychology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Bruinenberg, Marcel" sort="Bruinenberg, Marcel" uniqKey="Bruinenberg M" first="Marcel" last="Bruinenberg">Marcel Bruinenberg</name><affiliation><nlm:aff id="A108">University Medical Center Groningen, LifeLines Department, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Study, Lifelines Cohort" sort="Study, Lifelines Cohort" uniqKey="Study L" first="Lifelines Cohort" last="Study">Lifelines Cohort Study</name></author><author><name sortKey="Stolk, Ronald P" sort="Stolk, Ronald P" uniqKey="Stolk R" first="Ronald P" last="Stolk">Ronald P. Stolk</name><affiliation><nlm:aff id="A42">Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S" last="Kooner">Jaspal S. Kooner</name><affiliation><nlm:aff id="A109">Faculty of Medicine, National Heart & Lung Institute, Cardiovascular Science, Hammersmith Hospital, Hammersmith Campus, Imperial College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A110">Cath Laboratory, Cardiology, Ealing Hospital, Southall, UK</nlm:aff></affiliation></author><author><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><affiliation><nlm:aff id="A110">Cath Laboratory, Cardiology, Ealing Hospital, Southall, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A111">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Winkelmann, Bernhard R" sort="Winkelmann, Bernhard R" uniqKey="Winkelmann B" first="Bernhard R" last="Winkelmann">Bernhard R. Winkelmann</name><affiliation><nlm:aff id="A112">ClinPhenomics Study Center, Frankfurt, Germany</nlm:aff></affiliation></author><author><name sortKey="Boehm, Bernhard O" sort="Boehm, Bernhard O" uniqKey="Boehm B" first="Bernhard O" last="Boehm">Bernhard O. Boehm</name><affiliation><nlm:aff id="A113">Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Lucae, Susanne" sort="Lucae, Susanne" uniqKey="Lucae S" first="Susanne" last="Lucae">Susanne Lucae</name><affiliation><nlm:aff id="A64">Max Planck Institute of Psychiatry, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W" last="Penninx">Brenda W. Penninx</name><affiliation><nlm:aff id="A114">Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A115">Department of Psychiatry, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A116">Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Smit, Johannes H" sort="Smit, Johannes H" uniqKey="Smit J" first="Johannes H" last="Smit">Johannes H. Smit</name><affiliation><nlm:aff id="A114">Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Curhan, Gary" sort="Curhan, Gary" uniqKey="Curhan G" first="Gary" last="Curhan">Gary Curhan</name><affiliation><nlm:aff id="A117">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Mudgal, Poorva" sort="Mudgal, Poorva" uniqKey="Mudgal P" first="Poorva" last="Mudgal">Poorva Mudgal</name><affiliation><nlm:aff id="A65">Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Plenge, Robert M" sort="Plenge, Robert M" uniqKey="Plenge R" first="Robert M" last="Plenge">Robert M. Plenge</name><affiliation><nlm:aff id="A118">Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A119">Division of Genetics, Brigham and Women’s Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A120">Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Portas, Laura" sort="Portas, Laura" uniqKey="Portas L" first="Laura" last="Portas">Laura Portas</name><affiliation><nlm:aff id="A45">Institute of Population Genetics, CNR, Sassari, Italy</nlm:aff></affiliation></author><author><name sortKey="Persico, Ivana" sort="Persico, Ivana" uniqKey="Persico I" first="Ivana" last="Persico">Ivana Persico</name><affiliation><nlm:aff id="A45">Institute of Population Genetics, CNR, Sassari, Italy</nlm:aff></affiliation></author><author><name sortKey="Kirin, Mirna" sort="Kirin, Mirna" uniqKey="Kirin M" first="Mirna" last="Kirin">Mirna Kirin</name><affiliation><nlm:aff id="A46">Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="A46">Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Leach, Irene Mateo" sort="Leach, Irene Mateo" uniqKey="Leach I" first="Irene Mateo" last="Leach">Irene Mateo Leach</name><affiliation><nlm:aff id="A121">Division of Experimental Cardiology, Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Gilst, Wiek H" sort="Van Gilst, Wiek H" uniqKey="Van Gilst W" first="Wiek H" last="Van Gilst">Wiek H. Van Gilst</name><affiliation><nlm:aff id="A121">Division of Experimental Cardiology, Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name><affiliation><nlm:aff id="A48">Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Ongen, Halit" sort="Ongen, Halit" uniqKey="Ongen H" first="Halit" last="Ongen">Halit Ongen</name><affiliation><nlm:aff id="A48">Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A20">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Member of Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="A20">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Member of Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A122">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G" last="Uitterlinden">Andre G. Uitterlinden</name><affiliation><nlm:aff id="A20">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Member of Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A122">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Imboden, Medea" sort="Imboden, Medea" uniqKey="Imboden M" first="Medea" last="Imboden">Medea Imboden</name><affiliation><nlm:aff id="A66">Swiss Tropical and Public Health Institute, Basel, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A67">University of Basel, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Von Eckardstein, Arnold" sort="Von Eckardstein, Arnold" uniqKey="Von Eckardstein A" first="Arnold" last="Von Eckardstein">Arnold Von Eckardstein</name><affiliation><nlm:aff id="A123">Institute of Clinical Chemistry, University Hospital of Zurich, Zurich, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Cucca, Francesco" sort="Cucca, Francesco" uniqKey="Cucca F" first="Francesco" last="Cucca">Francesco Cucca</name><affiliation><nlm:aff id="A50">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Italy</nlm:aff></affiliation></author><author><name sortKey="Nagaraja, Ramaiah" sort="Nagaraja, Ramaiah" uniqKey="Nagaraja R" first="Ramaiah" last="Nagaraja">Ramaiah Nagaraja</name><affiliation><nlm:aff id="A124">Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Piras, Maria Grazia" sort="Piras, Maria Grazia" uniqKey="Piras M" first="Maria Grazia" last="Piras">Maria Grazia Piras</name><affiliation><nlm:aff id="A50">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Italy</nlm:aff></affiliation></author><author><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name><affiliation><nlm:aff id="A68">Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Schurmann, Claudia" sort="Schurmann, Claudia" uniqKey="Schurmann C" first="Claudia" last="Schurmann">Claudia Schurmann</name><affiliation><nlm:aff id="A4">Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Budde, Kathrin" sort="Budde, Kathrin" uniqKey="Budde K" first="Kathrin" last="Budde">Kathrin Budde</name><affiliation><nlm:aff id="A68">Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Ernst, Florian" sort="Ernst, Florian" uniqKey="Ernst F" first="Florian" last="Ernst">Florian Ernst</name><affiliation><nlm:aff id="A4">Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Farrington, Susan M" sort="Farrington, Susan M" uniqKey="Farrington S" first="Susan M" last="Farrington">Susan M. Farrington</name><affiliation><nlm:aff id="A5">Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Theodoratou, Evropi" sort="Theodoratou, Evropi" uniqKey="Theodoratou E" first="Evropi" last="Theodoratou">Evropi Theodoratou</name><affiliation><nlm:aff id="A46">Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation><nlm:aff id="A52">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A53">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation><nlm:aff id="A125">Medical Department, University of Leipzig, Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A126">Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Jula, Antti" sort="Jula, Antti" uniqKey="Jula A" first="Antti" last="Jula">Antti Jula</name><affiliation><nlm:aff id="A127">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name><affiliation><nlm:aff id="A12">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A128">Institute of Molecular Medicine, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation><nlm:aff id="A54">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Shin, So Youn" sort="Shin, So Youn" uniqKey="Shin S" first="So-Youn" last="Shin">So-Youn Shin</name><affiliation><nlm:aff id="A129">Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D" last="Spector">Tim D. Spector</name><affiliation><nlm:aff id="A55">King’s College London, St Thomas’ Hospital Campus, London, UK</nlm:aff></affiliation></author><author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name><affiliation><nlm:aff id="A7">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name><affiliation><nlm:aff id="A56">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A130">Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:aff id="A131">Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Viikari, Jorma" sort="Viikari, Jorma" uniqKey="Viikari J" first="Jorma" last="Viikari">Jorma Viikari</name><affiliation><nlm:aff id="A132">Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Hengstenberg, Christian" sort="Hengstenberg, Christian" uniqKey="Hengstenberg C" first="Christian" last="Hengstenberg">Christian Hengstenberg</name><affiliation><nlm:aff id="A133">Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Nelson, Christopher P" sort="Nelson, Christopher P" uniqKey="Nelson C" first="Christopher P" last="Nelson">Christopher P. Nelson</name><affiliation><nlm:aff id="A78">Leicester National Institute for Health Research (NIHR) Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A79">Department of Cardiovascular Sciences, University of Leicester, Leicester, UK</nlm:aff></affiliation></author><author><name sortKey="Consortium, Cardiogram" sort="Consortium, Cardiogram" uniqKey="Consortium C" first="Cardiogram" last="Consortium">Cardiogram Consortium</name></author><author><name sortKey="Consortium, Diagram" sort="Consortium, Diagram" uniqKey="Consortium D" first="Diagram" last="Consortium">Diagram Consortium</name></author><author><name sortKey="Consortium, Icbp" sort="Consortium, Icbp" uniqKey="Consortium I" first="Icbp" last="Consortium">Icbp Consortium</name></author><author><name sortKey="Consortium, Magic" sort="Consortium, Magic" uniqKey="Consortium M" first="Magic" last="Consortium">Magic Consortium</name></author><author><name sortKey="Meschia, James F" sort="Meschia, James F" uniqKey="Meschia J" first="James F" last="Meschia">James F. Meschia</name><affiliation><nlm:aff id="A134">Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff></affiliation></author><author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A" last="Nalls">Michael A. Nalls</name><affiliation><nlm:aff id="A135">Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Sharma, Pankaj" sort="Sharma, Pankaj" uniqKey="Sharma P" first="Pankaj" last="Sharma">Pankaj Sharma</name><affiliation><nlm:aff id="A136">Imperial College Cerebrovascular Research Unit, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Singleton, Andrew B" sort="Singleton, Andrew B" uniqKey="Singleton A" first="Andrew B" last="Singleton">Andrew B. Singleton</name><affiliation><nlm:aff id="A135">Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Kamatani, Naoyuki" sort="Kamatani, Naoyuki" uniqKey="Kamatani N" first="Naoyuki" last="Kamatani">Naoyuki Kamatani</name><affiliation><nlm:aff id="A137">Laboratory for International Alliance, Center for Genomic Medicine, RIKEN, Yokohama, Japan</nlm:aff></affiliation></author><author><name sortKey="Zeller, Tanja" sort="Zeller, Tanja" uniqKey="Zeller T" first="Tanja" last="Zeller">Tanja Zeller</name><affiliation><nlm:aff id="A61">University Heart Center Hamburg, Clinic for General and Interventional Cardiology, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Burnier, Michel" sort="Burnier, Michel" uniqKey="Burnier M" first="Michel" last="Burnier">Michel Burnier</name><affiliation><nlm:aff id="A138">Nephrology Division, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name><affiliation><nlm:aff id="A62">School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia</nlm:aff></affiliation></author><author><name sortKey="Laan, Maris" sort="Laan, Maris" uniqKey="Laan M" first="Maris" last="Laan">Maris Laan</name><affiliation><nlm:aff id="A63">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Klopp, Norman" sort="Klopp, Norman" uniqKey="Klopp N" first="Norman" last="Klopp">Norman Klopp</name><affiliation><nlm:aff id="A104">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hillege, Hans L" sort="Hillege, Hans L" uniqKey="Hillege H" first="Hans L" last="Hillege">Hans L. Hillege</name><affiliation><nlm:aff id="A37">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kloiber, Stefan" sort="Kloiber, Stefan" uniqKey="Kloiber S" first="Stefan" last="Kloiber">Stefan Kloiber</name><affiliation><nlm:aff id="A64">Max Planck Institute of Psychiatry, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Choi, Hyon" sort="Choi, Hyon" uniqKey="Choi H" first="Hyon" last="Choi">Hyon Choi</name><affiliation><nlm:aff id="A117">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A139">Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A140">Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Pirastu, Mario" sort="Pirastu, Mario" uniqKey="Pirastu M" first="Mario" last="Pirastu">Mario Pirastu</name><affiliation><nlm:aff id="A45">Institute of Population Genetics, CNR, Sassari, Italy</nlm:aff></affiliation></author><author><name sortKey="Tore, Silvia" sort="Tore, Silvia" uniqKey="Tore S" first="Silvia" last="Tore">Silvia Tore</name><affiliation><nlm:aff id="A45">Institute of Population Genetics, CNR, Sassari, Italy</nlm:aff></affiliation></author><author><name sortKey="Probst Hensch, Nicole M" sort="Probst Hensch, Nicole M" uniqKey="Probst Hensch N" first="Nicole M" last="Probst-Hensch">Nicole M. Probst-Hensch</name><affiliation><nlm:aff id="A66">Swiss Tropical and Public Health Institute, Basel, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A67">University of Basel, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation><nlm:aff id="A141">Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="A17">Icelandic Heart Association Research Institute, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name><affiliation><nlm:aff id="A19">University of Maryland School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation><nlm:aff id="A73">Department of Neurology, Section of Special Neurology, Medical University Graz, Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B" last="Whitfield">John B. Whitfield</name><affiliation><nlm:aff id="A22">Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation><nlm:aff id="A142">University of Texas–Houston Institute of Molecular Medicine, Houston, Texas, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A143">University of Texas–Houston School of Public Health, Houston, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Gasparini, Paolo" sort="Gasparini, Paolo" uniqKey="Gasparini P" first="Paolo" last="Gasparini">Paolo Gasparini</name><affiliation><nlm:aff id="A26">Institute for Maternal and Child Health, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Burlo Garofolo–Trieste, University of Trieste, Trieste, Italy</nlm:aff></affiliation></author><author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S" last="Siscovick">David S. Siscovick</name><affiliation><nlm:aff id="A27">Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A84">Department of Epidemiology, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A85">Department of Medicine, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polašek">Ozren Polašek</name><affiliation><nlm:aff id="A28">Faculty of Medicine, University of Split, Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="A46">Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="A28">Faculty of Medicine, University of Split, Split, Croatia</nlm:aff></affiliation><affiliation><nlm:aff id="A46">Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name><affiliation><nlm:aff id="A29">Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8199, Genomics and Molecular Physiology of Metabolic Diseases, Institut Pasteur de Lille, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation><nlm:aff id="A12">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A63">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J F" last="Loos">Ruth J F. Loos</name><affiliation><nlm:aff id="A31">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A32">Subdivision of Genetic Epidemiology, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Borecki, Ingrid B" sort="Borecki, Ingrid B" uniqKey="Borecki I" first="Ingrid B" last="Borecki">Ingrid B. Borecki</name><affiliation><nlm:aff id="A33">Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A144">Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation><nlm:aff id="A14">Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Gambaro, Giovanni" sort="Gambaro, Giovanni" uniqKey="Gambaro G" first="Giovanni" last="Gambaro">Giovanni Gambaro</name><affiliation><nlm:aff id="A145">Renal Program, Institute of Internal Medicine, Columbus-Gemelli University Hospital, Catholic University, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J" last="Deary">Ian J. Deary</name><affiliation><nlm:aff id="A35">Department of Psychology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Wolffenbuttel, Bruce H R" sort="Wolffenbuttel, Bruce H R" uniqKey="Wolffenbuttel B" first="Bruce H R" last="Wolffenbuttel">Bruce H R. Wolffenbuttel</name><affiliation><nlm:aff id="A146">Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Chambers, John C" sort="Chambers, John C" uniqKey="Chambers J" first="John C" last="Chambers">John C. Chambers</name><affiliation><nlm:aff id="A110">Cath Laboratory, Cardiology, Ealing Hospital, Southall, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A111">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="M Rz, Winfried" sort="M Rz, Winfried" uniqKey="M Rz W" first="Winfried" last="M Rz">Winfried M Rz</name><affiliation><nlm:aff id="A40">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A147">Synlab Centre of Laboratory Diagnostics, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P" last="Pramstaller">Peter P. Pramstaller</name><affiliation><nlm:aff id="A41">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck)</nlm:aff></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation><nlm:aff id="A42">Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation><nlm:aff id="A44">Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F" last="Wright">Alan F. Wright</name><affiliation><nlm:aff id="A5">Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name><affiliation><nlm:aff id="A148">Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name><affiliation><nlm:aff id="A48">Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A149">On behalf of PROCARDIS</nlm:aff></affiliation></author><author><name sortKey="Witteman, Jacqueline C M" sort="Witteman, Jacqueline C M" uniqKey="Witteman J" first="Jacqueline C M" last="Witteman">Jacqueline C M. Witteman</name><affiliation><nlm:aff id="A20">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Member of Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation><nlm:aff id="A50">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Italy</nlm:aff></affiliation></author><author><name sortKey="Schipf, Sabine" sort="Schipf, Sabine" uniqKey="Schipf S" first="Sabine" last="Schipf">Sabine Schipf</name><affiliation><nlm:aff id="A141">Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Dunlop, Malcolm G" sort="Dunlop, Malcolm G" uniqKey="Dunlop M" first="Malcolm G" last="Dunlop">Malcolm G. Dunlop</name><affiliation><nlm:aff id="A5">Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name><affiliation><nlm:aff id="A125">Medical Department, University of Leipzig, Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A126">Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Ripatti, Samuli" sort="Ripatti, Samuli" uniqKey="Ripatti S" first="Samuli" last="Ripatti">Samuli Ripatti</name><affiliation><nlm:aff id="A127">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A128">Institute of Molecular Medicine, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A129">Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation><nlm:aff id="A129">Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Toniolo, Daniela" sort="Toniolo, Daniela" uniqKey="Toniolo D" first="Daniela" last="Toniolo">Daniela Toniolo</name><affiliation><nlm:aff id="A7">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A150">Institute of Molecular Genetics, CNR, Pavia, Italy</nlm:aff></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name><affiliation><nlm:aff id="A56">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A130">Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation><nlm:aff id="A151">Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A152">Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Kao, W H Linda" sort="Kao, W H Linda" uniqKey="Kao W" first="W H Linda" last="Kao">W H Linda Kao</name><affiliation><nlm:aff id="A2">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A71">Welch Center for Prevention, Epidemiology and Clinical Research, John Hopkins University, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Ciullo, Marina" sort="Ciullo, Marina" uniqKey="Ciullo M" first="Marina" last="Ciullo">Marina Ciullo</name><affiliation><nlm:aff id="A8">Institute of Genetics and Biophysics A. Buzzati-Traverso, Consiglio Nazionale delle Ricerche (CNR), Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S" last="Fox">Caroline S. Fox</name><affiliation><nlm:aff id="A9">National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A10">National Heart, Lung, and Blood Institute’s Center for Population Studies, Framingham, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A153">Division of Endocrinology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Caulfield, Mark" sort="Caulfield, Mark" uniqKey="Caulfield M" first="Mark" last="Caulfield">Mark Caulfield</name><affiliation><nlm:aff id="A77">William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name><affiliation><nlm:aff id="A154">University Institute of Social and Preventive Medicine, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation><nlm:aff id="A3">Institute of Genetic Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23263486</idno><idno type="pmc">3663712</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663712</idno><idno type="RBID">PMC:3663712</idno><idno type="doi">10.1038/ng.2500</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002137</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002137</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide association analyses identify 18 new loci associated with serum urate concentrations</title><author><name sortKey="Kottgen, Anna" sort="Kottgen, Anna" uniqKey="Kottgen A" first="Anna" last="Köttgen">Anna Köttgen</name><affiliation><nlm:aff id="A1">Renal Division, Freiburg University Hospital, Freiburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Albrecht, Eva" sort="Albrecht, Eva" uniqKey="Albrecht E" first="Eva" last="Albrecht">Eva Albrecht</name><affiliation><nlm:aff id="A3">Institute of Genetic Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:aff id="A4">Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation><nlm:aff id="A5">Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Krumsiek, Jan" sort="Krumsiek, Jan" uniqKey="Krumsiek J" first="Jan" last="Krumsiek">Jan Krumsiek</name><affiliation><nlm:aff id="A6">Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hundertmark, Claudia" sort="Hundertmark, Claudia" uniqKey="Hundertmark C" first="Claudia" last="Hundertmark">Claudia Hundertmark</name><affiliation><nlm:aff id="A1">Renal Division, Freiburg University Hospital, Freiburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Pistis, Giorgio" sort="Pistis, Giorgio" uniqKey="Pistis G" first="Giorgio" last="Pistis">Giorgio Pistis</name><affiliation><nlm:aff id="A7">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Ruggiero, Daniela" sort="Ruggiero, Daniela" uniqKey="Ruggiero D" first="Daniela" last="Ruggiero">Daniela Ruggiero</name><affiliation><nlm:aff id="A8">Institute of Genetics and Biophysics A. Buzzati-Traverso, Consiglio Nazionale delle Ricerche (CNR), Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="O Eaghdha, Conall M" sort="O Eaghdha, Conall M" uniqKey="O Eaghdha C" first="Conall M" last="O Eaghdha">Conall M. O Eaghdha</name><affiliation><nlm:aff id="A9">National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A10">National Heart, Lung, and Blood Institute’s Center for Population Studies, Framingham, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Renal Division, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Haller, Toomas" sort="Haller, Toomas" uniqKey="Haller T" first="Toomas" last="Haller">Toomas Haller</name><affiliation><nlm:aff id="A12">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name><affiliation><nlm:aff id="A9">National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A10">National Heart, Lung, and Blood Institute’s Center for Population Studies, Framingham, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Department of Biostatistics, Boston University, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation><nlm:aff id="A14">Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D" last="Johnson">Andrew D. Johnson</name><affiliation><nlm:aff id="A9">National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A10">National Heart, Lung, and Blood Institute’s Center for Population Studies, Framingham, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name><affiliation><nlm:aff id="A15">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Swiss Institute of Bioinformatics, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V" last="Smith">Albert V. Smith</name><affiliation><nlm:aff id="A17">Icelandic Heart Association Research Institute, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Shi, Julia" sort="Shi, Julia" uniqKey="Shi J" first="Julia" last="Shi">Julia Shi</name><affiliation><nlm:aff id="A19">University of Maryland School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name><affiliation><nlm:aff id="A20">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Middelberg, Rita P S" sort="Middelberg, Rita P S" uniqKey="Middelberg R" first="Rita P S" last="Middelberg">Rita P S. Middelberg</name><affiliation><nlm:aff id="A21">Department of Medicine, Prince Charles Hospital, Chermside, Queensland, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Brown, Morris J" sort="Brown, Morris J" uniqKey="Brown M" first="Morris J" last="Brown">Morris J. Brown</name><affiliation><nlm:aff id="A23">Clinical Pharmacology Unit, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Gaffo, Angelo L" sort="Gaffo, Angelo L" uniqKey="Gaffo A" first="Angelo L" last="Gaffo">Angelo L. Gaffo</name><affiliation><nlm:aff id="A24">Division of Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A25">Birmingham Veterans Affairs Medical Center, University of Alabama at Birmingham, Birmingham, Alabama, USA</nlm:aff></affiliation></author><author><name sortKey="Pirastu, Nicola" sort="Pirastu, Nicola" uniqKey="Pirastu N" first="Nicola" last="Pirastu">Nicola Pirastu</name><affiliation><nlm:aff id="A26">Institute for Maternal and Child Health, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Burlo Garofolo–Trieste, University of Trieste, Trieste, Italy</nlm:aff></affiliation></author><author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name><affiliation><nlm:aff id="A27">Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="A5">Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Zemunik, Tatijana" sort="Zemunik, Tatijana" uniqKey="Zemunik T" first="Tatijana" last="Zemunik">Tatijana Zemunik</name><affiliation><nlm:aff id="A28">Faculty of Medicine, University of Split, Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Huffman, Jennifer" sort="Huffman, Jennifer" uniqKey="Huffman J" first="Jennifer" last="Huffman">Jennifer Huffman</name><affiliation><nlm:aff id="A5">Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Yengo, Loic" sort="Yengo, Loic" uniqKey="Yengo L" first="Loic" last="Yengo">Loic Yengo</name><affiliation><nlm:aff id="A29">Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8199, Genomics and Molecular Physiology of Metabolic Diseases, Institut Pasteur de Lille, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A30">CNRS UMR 8524, Laboratory of Mathematics, University Lille 1, Model for Data Analysis and Learning (MODAL) Team, Institut National de Recherche en Informatique et en Automatique (INRIA) Lille Nord–Europe, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="A31">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Demirkan, Ayse" sort="Demirkan, Ayse" uniqKey="Demirkan A" first="Ayse" last="Demirkan">Ayse Demirkan</name><affiliation><nlm:aff id="A32">Subdivision of Genetic Epidemiology, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Feitosa, Mary F" sort="Feitosa, Mary F" uniqKey="Feitosa M" first="Mary F" last="Feitosa">Mary F. Feitosa</name><affiliation><nlm:aff id="A33">Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="Liu, Xuan" sort="Liu, Xuan" uniqKey="Liu X" first="Xuan" last="Liu">Xuan Liu</name><affiliation><nlm:aff id="A13">Department of Biostatistics, Boston University, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Malerba, Giovanni" sort="Malerba, Giovanni" uniqKey="Malerba G" first="Giovanni" last="Malerba">Giovanni Malerba</name><affiliation><nlm:aff id="A34">Biology and Genetics Section, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy</nlm:aff></affiliation></author><author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M" last="Lopez">Lorna M. Lopez</name><affiliation><nlm:aff id="A35">Department of Psychology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation><nlm:aff id="A37">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Li, Xinzhong" sort="Li, Xinzhong" uniqKey="Li X" first="Xinzhong" last="Li">Xinzhong Li</name><affiliation><nlm:aff id="A38">Institute of Clinical Science, Faculty of Medicine, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E" last="Kleber">Marcus E. Kleber</name><affiliation><nlm:aff id="A39">Ludwigshafen Risk and Cardiovascular Health (LURIC) Study, Freiburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A" last="Hicks">Andrew A. Hicks</name><affiliation><nlm:aff id="A41">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck)</nlm:aff></affiliation></author><author><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M" last="Nolte">Ilja M. Nolte</name><affiliation><nlm:aff id="A42">Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Johansson, Asa" sort="Johansson, Asa" uniqKey="Johansson A" first="Asa" last="Johansson">Asa Johansson</name><affiliation><nlm:aff id="A43">Uppsala Clinical Research Center, Uppsala University Hospital, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A44">Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Murgia, Federico" sort="Murgia, Federico" uniqKey="Murgia F" first="Federico" last="Murgia">Federico Murgia</name><affiliation><nlm:aff id="A45">Institute of Population Genetics, CNR, Sassari, Italy</nlm:aff></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H" last="Wild">Sarah H. Wild</name><affiliation><nlm:aff id="A46">Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Bakker, Stephan J L" sort="Bakker, Stephan J L" uniqKey="Bakker S" first="Stephan J L" last="Bakker">Stephan J L. Bakker</name><affiliation><nlm:aff id="A47">Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Peden, John F" sort="Peden, John F" uniqKey="Peden J" first="John F" last="Peden">John F. Peden</name><affiliation><nlm:aff id="A48">Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name><affiliation><nlm:aff id="A20">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Member of Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Steri, Maristella" sort="Steri, Maristella" uniqKey="Steri M" first="Maristella" last="Steri">Maristella Steri</name><affiliation><nlm:aff id="A50">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Italy</nlm:aff></affiliation></author><author><name sortKey="Tenesa, Albert" sort="Tenesa, Albert" uniqKey="Tenesa A" first="Albert" last="Tenesa">Albert Tenesa</name><affiliation><nlm:aff id="A5">Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A51">Roslin Institute, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Lagou, Vasiliki" sort="Lagou, Vasiliki" uniqKey="Lagou V" first="Vasiliki" last="Lagou">Vasiliki Lagou</name><affiliation><nlm:aff id="A52">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A53">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Salo, Perttu" sort="Salo, Perttu" uniqKey="Salo P" first="Perttu" last="Salo">Perttu Salo</name><affiliation><nlm:aff id="A54">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation><nlm:aff id="A55">King’s College London, St Thomas’ Hospital Campus, London, UK</nlm:aff></affiliation></author><author><name sortKey="Rose, Lynda M" sort="Rose, Lynda M" uniqKey="Rose L" first="Lynda M" last="Rose">Lynda M. Rose</name><affiliation><nlm:aff id="A56">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:aff id="A57">Fimlab Laboratories, University of Tampere and Tampere University Hospital, Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Woodward, Owen M" sort="Woodward, Owen M" uniqKey="Woodward O" first="Owen M" last="Woodward">Owen M. Woodward</name><affiliation><nlm:aff id="A58">Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Okada, Yukinori" sort="Okada, Yukinori" uniqKey="Okada Y" first="Yukinori" last="Okada">Yukinori Okada</name><affiliation><nlm:aff id="A59">Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, Tokyo, Japan</nlm:aff></affiliation><affiliation><nlm:aff id="A60">Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Tin, Adrienne" sort="Tin, Adrienne" uniqKey="Tin A" first="Adrienne" last="Tin">Adrienne Tin</name><affiliation><nlm:aff id="A2">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Muller, Christian" sort="Muller, Christian" uniqKey="Muller C" first="Christian" last="Müller">Christian Müller</name><affiliation><nlm:aff id="A61">University Heart Center Hamburg, Clinic for General and Interventional Cardiology, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Oldmeadow, Christopher" sort="Oldmeadow, Christopher" uniqKey="Oldmeadow C" first="Christopher" last="Oldmeadow">Christopher Oldmeadow</name><affiliation><nlm:aff id="A62">School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia</nlm:aff></affiliation></author><author><name sortKey="Putku, Margus" sort="Putku, Margus" uniqKey="Putku M" first="Margus" last="Putku">Margus Putku</name><affiliation><nlm:aff id="A63">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Czamara, Darina" sort="Czamara, Darina" uniqKey="Czamara D" first="Darina" last="Czamara">Darina Czamara</name><affiliation><nlm:aff id="A64">Max Planck Institute of Psychiatry, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="A65">Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Frogheri, Laura" sort="Frogheri, Laura" uniqKey="Frogheri L" first="Laura" last="Frogheri">Laura Frogheri</name><affiliation><nlm:aff id="A45">Institute of Population Genetics, CNR, Sassari, Italy</nlm:aff></affiliation></author><author><name sortKey="Thun, Gian Andri" sort="Thun, Gian Andri" uniqKey="Thun G" first="Gian Andri" last="Thun">Gian Andri Thun</name><affiliation><nlm:aff id="A66">Swiss Tropical and Public Health Institute, Basel, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A67">University of Basel, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Grotevendt, Anne" sort="Grotevendt, Anne" uniqKey="Grotevendt A" first="Anne" last="Grotevendt">Anne Grotevendt</name><affiliation><nlm:aff id="A68">Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Gislason, Gauti Kjartan" sort="Gislason, Gauti Kjartan" uniqKey="Gislason G" first="Gauti Kjartan" last="Gislason">Gauti Kjartan Gislason</name><affiliation><nlm:aff id="A17">Icelandic Heart Association Research Institute, Kopavogur, Iceland</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="A69">Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><affiliation><nlm:aff id="A69">Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Mcardle, Patrick" sort="Mcardle, Patrick" uniqKey="Mcardle P" first="Patrick" last="Mcardle">Patrick Mcardle</name><affiliation><nlm:aff id="A19">University of Maryland School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R" last="Shuldiner">Alan R. Shuldiner</name><affiliation><nlm:aff id="A19">University of Maryland School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation><nlm:aff id="A70">University of Texas Health Science Center at Houston, Houston, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Coresh, Josef" sort="Coresh, Josef" uniqKey="Coresh J" first="Josef" last="Coresh">Josef Coresh</name><affiliation><nlm:aff id="A2">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A71">Welch Center for Prevention, Epidemiology and Clinical Research, John Hopkins University, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation><nlm:aff id="A72">Institute of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Schallert, Michael" sort="Schallert, Michael" uniqKey="Schallert M" first="Michael" last="Schallert">Michael Schallert</name><affiliation><nlm:aff id="A73">Department of Neurology, Section of Special Neurology, Medical University Graz, Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="A22">Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W" last="Montgomery">Grant W. Montgomery</name><affiliation><nlm:aff id="A22">Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Kubo, Michiaki" sort="Kubo, Michiaki" uniqKey="Kubo M" first="Michiaki" last="Kubo">Michiaki Kubo</name><affiliation><nlm:aff id="A74">Laboratory for Genotyping Development, Center for Genomic Medicine, RIKEN, Yokohama, Japan</nlm:aff></affiliation></author><author><name sortKey="Nakamura, Yusuke" sort="Nakamura, Yusuke" uniqKey="Nakamura Y" first="Yusuke" last="Nakamura">Yusuke Nakamura</name><affiliation><nlm:aff id="A75">Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Tanaka, Toshihiro" sort="Tanaka, Toshihiro" uniqKey="Tanaka T" first="Toshihiro" last="Tanaka">Toshihiro Tanaka</name><affiliation><nlm:aff id="A76">Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan</nlm:aff></affiliation></author><author><name sortKey="Munroe, Patricia B" sort="Munroe, Patricia B" uniqKey="Munroe P" first="Patricia B" last="Munroe">Patricia B. Munroe</name><affiliation><nlm:aff id="A77">William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J" last="Samani">Nilesh J. Samani</name><affiliation><nlm:aff id="A78">Leicester National Institute for Health Research (NIHR) Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A79">Department of Cardiovascular Sciences, University of Leicester, Leicester, UK</nlm:aff></affiliation></author><author><name sortKey="Jacobs, David R" sort="Jacobs, David R" uniqKey="Jacobs D" first="David R" last="Jacobs">David R. Jacobs</name><affiliation><nlm:aff id="A80">Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Liu, Kiang" sort="Liu, Kiang" uniqKey="Liu K" first="Kiang" last="Liu">Kiang Liu</name><affiliation><nlm:aff id="A81">Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA</nlm:aff></affiliation></author><author><name sortKey="D Damo, Pio" sort="D Damo, Pio" uniqKey="D Damo P" first="Pio" last="D Damo">Pio D Damo</name><affiliation><nlm:aff id="A26">Institute for Maternal and Child Health, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Burlo Garofolo–Trieste, University of Trieste, Trieste, Italy</nlm:aff></affiliation></author><author><name sortKey="Ulivi, Sheila" sort="Ulivi, Sheila" uniqKey="Ulivi S" first="Sheila" last="Ulivi">Sheila Ulivi</name><affiliation><nlm:aff id="A82">Intitute for Maternal and Child Health, IRCCS Burlo Garofolo–Trieste, Trieste, Italy</nlm:aff></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I" last="Rotter">Jerome I. Rotter</name><affiliation><nlm:aff id="A83">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name><affiliation><nlm:aff id="A27">Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A84">Department of Epidemiology, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A85">Department of Medicine, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A86">Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Department of Health Services, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:aff id="A88">Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Waeber, Gerard" sort="Waeber, Gerard" uniqKey="Waeber G" first="Gerard" last="Waeber">Gerard Waeber</name><affiliation><nlm:aff id="A88">Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Campbell, Susan" sort="Campbell, Susan" uniqKey="Campbell S" first="Susan" last="Campbell">Susan Campbell</name><affiliation><nlm:aff id="A5">Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Devuyst, Olivier" sort="Devuyst, Olivier" uniqKey="Devuyst O" first="Olivier" last="Devuyst">Olivier Devuyst</name><affiliation><nlm:aff id="A89">Institute of Physiology, Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Navarro, Pau" sort="Navarro, Pau" uniqKey="Navarro P" first="Pau" last="Navarro">Pau Navarro</name><affiliation><nlm:aff id="A5">Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name><affiliation><nlm:aff id="A28">Faculty of Medicine, University of Split, Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Hastie, Nicholas" sort="Hastie, Nicholas" uniqKey="Hastie N" first="Nicholas" last="Hastie">Nicholas Hastie</name><affiliation><nlm:aff id="A5">Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><affiliation><nlm:aff id="A90">Unité Mixte de Recherche en Santé (UMRS) 1018, University Paris Sud 11, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="A29">Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8199, Genomics and Molecular Physiology of Metabolic Diseases, Institut Pasteur de Lille, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation><nlm:aff id="A12">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A63">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Salumets, Andres" sort="Salumets, Andres" uniqKey="Salumets A" first="Andres" last="Salumets">Andres Salumets</name><affiliation><nlm:aff id="A12">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A92">Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A93">Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay Tee" last="Khaw">Kay Tee Khaw</name><affiliation><nlm:aff id="A94">Clinical Gerontology Unit, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation><nlm:aff id="A31">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A31">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name><affiliation><nlm:aff id="A32">Subdivision of Genetic Epidemiology, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kraja, Aldi" sort="Kraja, Aldi" uniqKey="Kraja A" first="Aldi" last="Kraja">Aldi Kraja</name><affiliation><nlm:aff id="A33">Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="Zhang, Qunyuan" sort="Zhang, Qunyuan" uniqKey="Zhang Q" first="Qunyuan" last="Zhang">Qunyuan Zhang</name><affiliation><nlm:aff id="A33">Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="Wild, Philipp S" sort="Wild, Philipp S" uniqKey="Wild P" first="Philipp S" last="Wild">Philipp S. Wild</name><affiliation><nlm:aff id="A95">Center for Thrombosis and Hemostasis, University Medical Center Mainz, Johannes Gutenberg University Mainz, Mainz, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A96">Department of Medicine II, University Medical Center Mainz, Johannes Gutenberg University Mainz, Mainz, Germany</nlm:aff></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J" last="Scott">Rodney J. Scott</name><affiliation><nlm:aff id="A97">School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia</nlm:aff></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G" last="Holliday">Elizabeth G. Holliday</name><affiliation><nlm:aff id="A62">School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia</nlm:aff></affiliation></author><author><name sortKey="Org, Elin" sort="Org, Elin" uniqKey="Org E" first="Elin" last="Org">Elin Org</name><affiliation><nlm:aff id="A63">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Viigimaa, Margus" sort="Viigimaa, Margus" uniqKey="Viigimaa M" first="Margus" last="Viigimaa">Margus Viigimaa</name><affiliation><nlm:aff id="A98">Chair of Medical Physics, Department of Biomedical Engineering, Tallinn University of Technology, Tallinn, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A99">Centre of Cardiology, North Estonia Medical Centre, Tallinn, Estonia</nlm:aff></affiliation></author><author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name><affiliation><nlm:aff id="A100">Geniatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Metter, Jeffrey E" sort="Metter, Jeffrey E" uniqKey="Metter J" first="Jeffrey E" last="Metter">Jeffrey E. Metter</name><affiliation><nlm:aff id="A14">Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Lupo, Antonio" sort="Lupo, Antonio" uniqKey="Lupo A" first="Antonio" last="Lupo">Antonio Lupo</name><affiliation><nlm:aff id="A101">Division of Nephrology, Department of Medicine, University of Verona, Verona, Italy</nlm:aff></affiliation></author><author><name sortKey="Trabetti, Elisabetta" sort="Trabetti, Elisabetta" uniqKey="Trabetti E" first="Elisabetta" last="Trabetti">Elisabetta Trabetti</name><affiliation><nlm:aff id="A34">Biology and Genetics Section, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy</nlm:aff></affiliation></author><author><name sortKey="Sorice, Rossella" sort="Sorice, Rossella" uniqKey="Sorice R" first="Rossella" last="Sorice">Rossella Sorice</name><affiliation><nlm:aff id="A8">Institute of Genetics and Biophysics A. Buzzati-Traverso, Consiglio Nazionale delle Ricerche (CNR), Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Doring, Angela" sort="Doring, Angela" uniqKey="Doring A" first="Angela" last="Döring">Angela Döring</name><affiliation><nlm:aff id="A102">Institute of Epidemiology II, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A103">Institute of Epidemiology I, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Lattka, Eva" sort="Lattka, Eva" uniqKey="Lattka E" first="Eva" last="Lattka">Eva Lattka</name><affiliation><nlm:aff id="A104">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Strauch, Konstantin" sort="Strauch, Konstantin" uniqKey="Strauch K" first="Konstantin" last="Strauch">Konstantin Strauch</name><affiliation><nlm:aff id="A3">Institute of Genetic Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A105">Chair of Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Theis, Fabian" sort="Theis, Fabian" uniqKey="Theis F" first="Fabian" last="Theis">Fabian Theis</name><affiliation><nlm:aff id="A6">Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Waldenberger, Melanie" sort="Waldenberger, Melanie" uniqKey="Waldenberger M" first="Melanie" last="Waldenberger">Melanie Waldenberger</name><affiliation><nlm:aff id="A104">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H-Erich" last="Wichmann">H-Erich Wichmann</name><affiliation><nlm:aff id="A103">Institute of Epidemiology I, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A106">Chair of Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A107">Klinikum Grosshadern, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Davies, Gail" sort="Davies, Gail" uniqKey="Davies G" first="Gail" last="Davies">Gail Davies</name><affiliation><nlm:aff id="A35">Department of Psychology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Gow, Alan J" sort="Gow, Alan J" uniqKey="Gow A" first="Alan J" last="Gow">Alan J. Gow</name><affiliation><nlm:aff id="A35">Department of Psychology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Bruinenberg, Marcel" sort="Bruinenberg, Marcel" uniqKey="Bruinenberg M" first="Marcel" last="Bruinenberg">Marcel Bruinenberg</name><affiliation><nlm:aff id="A108">University Medical Center Groningen, LifeLines Department, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Study, Lifelines Cohort" sort="Study, Lifelines Cohort" uniqKey="Study L" first="Lifelines Cohort" last="Study">Lifelines Cohort Study</name></author><author><name sortKey="Stolk, Ronald P" sort="Stolk, Ronald P" uniqKey="Stolk R" first="Ronald P" last="Stolk">Ronald P. Stolk</name><affiliation><nlm:aff id="A42">Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S" last="Kooner">Jaspal S. Kooner</name><affiliation><nlm:aff id="A109">Faculty of Medicine, National Heart & Lung Institute, Cardiovascular Science, Hammersmith Hospital, Hammersmith Campus, Imperial College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A110">Cath Laboratory, Cardiology, Ealing Hospital, Southall, UK</nlm:aff></affiliation></author><author><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><affiliation><nlm:aff id="A110">Cath Laboratory, Cardiology, Ealing Hospital, Southall, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A111">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Winkelmann, Bernhard R" sort="Winkelmann, Bernhard R" uniqKey="Winkelmann B" first="Bernhard R" last="Winkelmann">Bernhard R. Winkelmann</name><affiliation><nlm:aff id="A112">ClinPhenomics Study Center, Frankfurt, Germany</nlm:aff></affiliation></author><author><name sortKey="Boehm, Bernhard O" sort="Boehm, Bernhard O" uniqKey="Boehm B" first="Bernhard O" last="Boehm">Bernhard O. Boehm</name><affiliation><nlm:aff id="A113">Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Lucae, Susanne" sort="Lucae, Susanne" uniqKey="Lucae S" first="Susanne" last="Lucae">Susanne Lucae</name><affiliation><nlm:aff id="A64">Max Planck Institute of Psychiatry, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W" last="Penninx">Brenda W. Penninx</name><affiliation><nlm:aff id="A114">Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A115">Department of Psychiatry, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A116">Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Smit, Johannes H" sort="Smit, Johannes H" uniqKey="Smit J" first="Johannes H" last="Smit">Johannes H. Smit</name><affiliation><nlm:aff id="A114">Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Curhan, Gary" sort="Curhan, Gary" uniqKey="Curhan G" first="Gary" last="Curhan">Gary Curhan</name><affiliation><nlm:aff id="A117">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Mudgal, Poorva" sort="Mudgal, Poorva" uniqKey="Mudgal P" first="Poorva" last="Mudgal">Poorva Mudgal</name><affiliation><nlm:aff id="A65">Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Plenge, Robert M" sort="Plenge, Robert M" uniqKey="Plenge R" first="Robert M" last="Plenge">Robert M. Plenge</name><affiliation><nlm:aff id="A118">Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A119">Division of Genetics, Brigham and Women’s Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A120">Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Portas, Laura" sort="Portas, Laura" uniqKey="Portas L" first="Laura" last="Portas">Laura Portas</name><affiliation><nlm:aff id="A45">Institute of Population Genetics, CNR, Sassari, Italy</nlm:aff></affiliation></author><author><name sortKey="Persico, Ivana" sort="Persico, Ivana" uniqKey="Persico I" first="Ivana" last="Persico">Ivana Persico</name><affiliation><nlm:aff id="A45">Institute of Population Genetics, CNR, Sassari, Italy</nlm:aff></affiliation></author><author><name sortKey="Kirin, Mirna" sort="Kirin, Mirna" uniqKey="Kirin M" first="Mirna" last="Kirin">Mirna Kirin</name><affiliation><nlm:aff id="A46">Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="A46">Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Leach, Irene Mateo" sort="Leach, Irene Mateo" uniqKey="Leach I" first="Irene Mateo" last="Leach">Irene Mateo Leach</name><affiliation><nlm:aff id="A121">Division of Experimental Cardiology, Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Gilst, Wiek H" sort="Van Gilst, Wiek H" uniqKey="Van Gilst W" first="Wiek H" last="Van Gilst">Wiek H. Van Gilst</name><affiliation><nlm:aff id="A121">Division of Experimental Cardiology, Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name><affiliation><nlm:aff id="A48">Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Ongen, Halit" sort="Ongen, Halit" uniqKey="Ongen H" first="Halit" last="Ongen">Halit Ongen</name><affiliation><nlm:aff id="A48">Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A20">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Member of Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="A20">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Member of Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A122">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G" last="Uitterlinden">Andre G. Uitterlinden</name><affiliation><nlm:aff id="A20">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Member of Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A122">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Imboden, Medea" sort="Imboden, Medea" uniqKey="Imboden M" first="Medea" last="Imboden">Medea Imboden</name><affiliation><nlm:aff id="A66">Swiss Tropical and Public Health Institute, Basel, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A67">University of Basel, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Von Eckardstein, Arnold" sort="Von Eckardstein, Arnold" uniqKey="Von Eckardstein A" first="Arnold" last="Von Eckardstein">Arnold Von Eckardstein</name><affiliation><nlm:aff id="A123">Institute of Clinical Chemistry, University Hospital of Zurich, Zurich, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Cucca, Francesco" sort="Cucca, Francesco" uniqKey="Cucca F" first="Francesco" last="Cucca">Francesco Cucca</name><affiliation><nlm:aff id="A50">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Italy</nlm:aff></affiliation></author><author><name sortKey="Nagaraja, Ramaiah" sort="Nagaraja, Ramaiah" uniqKey="Nagaraja R" first="Ramaiah" last="Nagaraja">Ramaiah Nagaraja</name><affiliation><nlm:aff id="A124">Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Piras, Maria Grazia" sort="Piras, Maria Grazia" uniqKey="Piras M" first="Maria Grazia" last="Piras">Maria Grazia Piras</name><affiliation><nlm:aff id="A50">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Italy</nlm:aff></affiliation></author><author><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name><affiliation><nlm:aff id="A68">Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Schurmann, Claudia" sort="Schurmann, Claudia" uniqKey="Schurmann C" first="Claudia" last="Schurmann">Claudia Schurmann</name><affiliation><nlm:aff id="A4">Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Budde, Kathrin" sort="Budde, Kathrin" uniqKey="Budde K" first="Kathrin" last="Budde">Kathrin Budde</name><affiliation><nlm:aff id="A68">Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Ernst, Florian" sort="Ernst, Florian" uniqKey="Ernst F" first="Florian" last="Ernst">Florian Ernst</name><affiliation><nlm:aff id="A4">Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Farrington, Susan M" sort="Farrington, Susan M" uniqKey="Farrington S" first="Susan M" last="Farrington">Susan M. Farrington</name><affiliation><nlm:aff id="A5">Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Theodoratou, Evropi" sort="Theodoratou, Evropi" uniqKey="Theodoratou E" first="Evropi" last="Theodoratou">Evropi Theodoratou</name><affiliation><nlm:aff id="A46">Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation><nlm:aff id="A52">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A53">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation><nlm:aff id="A125">Medical Department, University of Leipzig, Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A126">Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Jula, Antti" sort="Jula, Antti" uniqKey="Jula A" first="Antti" last="Jula">Antti Jula</name><affiliation><nlm:aff id="A127">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name><affiliation><nlm:aff id="A12">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A128">Institute of Molecular Medicine, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation><nlm:aff id="A54">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Shin, So Youn" sort="Shin, So Youn" uniqKey="Shin S" first="So-Youn" last="Shin">So-Youn Shin</name><affiliation><nlm:aff id="A129">Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D" last="Spector">Tim D. Spector</name><affiliation><nlm:aff id="A55">King’s College London, St Thomas’ Hospital Campus, London, UK</nlm:aff></affiliation></author><author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name><affiliation><nlm:aff id="A7">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name><affiliation><nlm:aff id="A56">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A130">Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:aff id="A131">Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Viikari, Jorma" sort="Viikari, Jorma" uniqKey="Viikari J" first="Jorma" last="Viikari">Jorma Viikari</name><affiliation><nlm:aff id="A132">Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Hengstenberg, Christian" sort="Hengstenberg, Christian" uniqKey="Hengstenberg C" first="Christian" last="Hengstenberg">Christian Hengstenberg</name><affiliation><nlm:aff id="A133">Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Nelson, Christopher P" sort="Nelson, Christopher P" uniqKey="Nelson C" first="Christopher P" last="Nelson">Christopher P. Nelson</name><affiliation><nlm:aff id="A78">Leicester National Institute for Health Research (NIHR) Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A79">Department of Cardiovascular Sciences, University of Leicester, Leicester, UK</nlm:aff></affiliation></author><author><name sortKey="Consortium, Cardiogram" sort="Consortium, Cardiogram" uniqKey="Consortium C" first="Cardiogram" last="Consortium">Cardiogram Consortium</name></author><author><name sortKey="Consortium, Diagram" sort="Consortium, Diagram" uniqKey="Consortium D" first="Diagram" last="Consortium">Diagram Consortium</name></author><author><name sortKey="Consortium, Icbp" sort="Consortium, Icbp" uniqKey="Consortium I" first="Icbp" last="Consortium">Icbp Consortium</name></author><author><name sortKey="Consortium, Magic" sort="Consortium, Magic" uniqKey="Consortium M" first="Magic" last="Consortium">Magic Consortium</name></author><author><name sortKey="Meschia, James F" sort="Meschia, James F" uniqKey="Meschia J" first="James F" last="Meschia">James F. Meschia</name><affiliation><nlm:aff id="A134">Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff></affiliation></author><author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A" last="Nalls">Michael A. Nalls</name><affiliation><nlm:aff id="A135">Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Sharma, Pankaj" sort="Sharma, Pankaj" uniqKey="Sharma P" first="Pankaj" last="Sharma">Pankaj Sharma</name><affiliation><nlm:aff id="A136">Imperial College Cerebrovascular Research Unit, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Singleton, Andrew B" sort="Singleton, Andrew B" uniqKey="Singleton A" first="Andrew B" last="Singleton">Andrew B. Singleton</name><affiliation><nlm:aff id="A135">Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Kamatani, Naoyuki" sort="Kamatani, Naoyuki" uniqKey="Kamatani N" first="Naoyuki" last="Kamatani">Naoyuki Kamatani</name><affiliation><nlm:aff id="A137">Laboratory for International Alliance, Center for Genomic Medicine, RIKEN, Yokohama, Japan</nlm:aff></affiliation></author><author><name sortKey="Zeller, Tanja" sort="Zeller, Tanja" uniqKey="Zeller T" first="Tanja" last="Zeller">Tanja Zeller</name><affiliation><nlm:aff id="A61">University Heart Center Hamburg, Clinic for General and Interventional Cardiology, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Burnier, Michel" sort="Burnier, Michel" uniqKey="Burnier M" first="Michel" last="Burnier">Michel Burnier</name><affiliation><nlm:aff id="A138">Nephrology Division, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name><affiliation><nlm:aff id="A62">School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia</nlm:aff></affiliation></author><author><name sortKey="Laan, Maris" sort="Laan, Maris" uniqKey="Laan M" first="Maris" last="Laan">Maris Laan</name><affiliation><nlm:aff id="A63">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Klopp, Norman" sort="Klopp, Norman" uniqKey="Klopp N" first="Norman" last="Klopp">Norman Klopp</name><affiliation><nlm:aff id="A104">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hillege, Hans L" sort="Hillege, Hans L" uniqKey="Hillege H" first="Hans L" last="Hillege">Hans L. Hillege</name><affiliation><nlm:aff id="A37">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kloiber, Stefan" sort="Kloiber, Stefan" uniqKey="Kloiber S" first="Stefan" last="Kloiber">Stefan Kloiber</name><affiliation><nlm:aff id="A64">Max Planck Institute of Psychiatry, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Choi, Hyon" sort="Choi, Hyon" uniqKey="Choi H" first="Hyon" last="Choi">Hyon Choi</name><affiliation><nlm:aff id="A117">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A139">Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A140">Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Pirastu, Mario" sort="Pirastu, Mario" uniqKey="Pirastu M" first="Mario" last="Pirastu">Mario Pirastu</name><affiliation><nlm:aff id="A45">Institute of Population Genetics, CNR, Sassari, Italy</nlm:aff></affiliation></author><author><name sortKey="Tore, Silvia" sort="Tore, Silvia" uniqKey="Tore S" first="Silvia" last="Tore">Silvia Tore</name><affiliation><nlm:aff id="A45">Institute of Population Genetics, CNR, Sassari, Italy</nlm:aff></affiliation></author><author><name sortKey="Probst Hensch, Nicole M" sort="Probst Hensch, Nicole M" uniqKey="Probst Hensch N" first="Nicole M" last="Probst-Hensch">Nicole M. Probst-Hensch</name><affiliation><nlm:aff id="A66">Swiss Tropical and Public Health Institute, Basel, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A67">University of Basel, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation><nlm:aff id="A141">Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="A17">Icelandic Heart Association Research Institute, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name><affiliation><nlm:aff id="A19">University of Maryland School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation><nlm:aff id="A73">Department of Neurology, Section of Special Neurology, Medical University Graz, Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B" last="Whitfield">John B. Whitfield</name><affiliation><nlm:aff id="A22">Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation><nlm:aff id="A142">University of Texas–Houston Institute of Molecular Medicine, Houston, Texas, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A143">University of Texas–Houston School of Public Health, Houston, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Gasparini, Paolo" sort="Gasparini, Paolo" uniqKey="Gasparini P" first="Paolo" last="Gasparini">Paolo Gasparini</name><affiliation><nlm:aff id="A26">Institute for Maternal and Child Health, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Burlo Garofolo–Trieste, University of Trieste, Trieste, Italy</nlm:aff></affiliation></author><author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S" last="Siscovick">David S. Siscovick</name><affiliation><nlm:aff id="A27">Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A84">Department of Epidemiology, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A85">Department of Medicine, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polašek">Ozren Polašek</name><affiliation><nlm:aff id="A28">Faculty of Medicine, University of Split, Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="A46">Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="A28">Faculty of Medicine, University of Split, Split, Croatia</nlm:aff></affiliation><affiliation><nlm:aff id="A46">Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name><affiliation><nlm:aff id="A29">Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8199, Genomics and Molecular Physiology of Metabolic Diseases, Institut Pasteur de Lille, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation><nlm:aff id="A12">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A63">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J F" last="Loos">Ruth J F. Loos</name><affiliation><nlm:aff id="A31">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A32">Subdivision of Genetic Epidemiology, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Borecki, Ingrid B" sort="Borecki, Ingrid B" uniqKey="Borecki I" first="Ingrid B" last="Borecki">Ingrid B. Borecki</name><affiliation><nlm:aff id="A33">Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A144">Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation><nlm:aff id="A14">Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Gambaro, Giovanni" sort="Gambaro, Giovanni" uniqKey="Gambaro G" first="Giovanni" last="Gambaro">Giovanni Gambaro</name><affiliation><nlm:aff id="A145">Renal Program, Institute of Internal Medicine, Columbus-Gemelli University Hospital, Catholic University, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J" last="Deary">Ian J. Deary</name><affiliation><nlm:aff id="A35">Department of Psychology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Wolffenbuttel, Bruce H R" sort="Wolffenbuttel, Bruce H R" uniqKey="Wolffenbuttel B" first="Bruce H R" last="Wolffenbuttel">Bruce H R. Wolffenbuttel</name><affiliation><nlm:aff id="A146">Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Chambers, John C" sort="Chambers, John C" uniqKey="Chambers J" first="John C" last="Chambers">John C. Chambers</name><affiliation><nlm:aff id="A110">Cath Laboratory, Cardiology, Ealing Hospital, Southall, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A111">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="M Rz, Winfried" sort="M Rz, Winfried" uniqKey="M Rz W" first="Winfried" last="M Rz">Winfried M Rz</name><affiliation><nlm:aff id="A40">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A147">Synlab Centre of Laboratory Diagnostics, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P" last="Pramstaller">Peter P. Pramstaller</name><affiliation><nlm:aff id="A41">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck)</nlm:aff></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation><nlm:aff id="A42">Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation><nlm:aff id="A44">Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F" last="Wright">Alan F. Wright</name><affiliation><nlm:aff id="A5">Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name><affiliation><nlm:aff id="A148">Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name><affiliation><nlm:aff id="A48">Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A149">On behalf of PROCARDIS</nlm:aff></affiliation></author><author><name sortKey="Witteman, Jacqueline C M" sort="Witteman, Jacqueline C M" uniqKey="Witteman J" first="Jacqueline C M" last="Witteman">Jacqueline C M. Witteman</name><affiliation><nlm:aff id="A20">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Member of Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation><nlm:aff id="A50">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Italy</nlm:aff></affiliation></author><author><name sortKey="Schipf, Sabine" sort="Schipf, Sabine" uniqKey="Schipf S" first="Sabine" last="Schipf">Sabine Schipf</name><affiliation><nlm:aff id="A141">Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Dunlop, Malcolm G" sort="Dunlop, Malcolm G" uniqKey="Dunlop M" first="Malcolm G" last="Dunlop">Malcolm G. Dunlop</name><affiliation><nlm:aff id="A5">Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name><affiliation><nlm:aff id="A125">Medical Department, University of Leipzig, Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A126">Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Ripatti, Samuli" sort="Ripatti, Samuli" uniqKey="Ripatti S" first="Samuli" last="Ripatti">Samuli Ripatti</name><affiliation><nlm:aff id="A127">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A128">Institute of Molecular Medicine, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A129">Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation><nlm:aff id="A129">Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Toniolo, Daniela" sort="Toniolo, Daniela" uniqKey="Toniolo D" first="Daniela" last="Toniolo">Daniela Toniolo</name><affiliation><nlm:aff id="A7">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A150">Institute of Molecular Genetics, CNR, Pavia, Italy</nlm:aff></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name><affiliation><nlm:aff id="A56">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A130">Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation><nlm:aff id="A151">Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A152">Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Kao, W H Linda" sort="Kao, W H Linda" uniqKey="Kao W" first="W H Linda" last="Kao">W H Linda Kao</name><affiliation><nlm:aff id="A2">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A71">Welch Center for Prevention, Epidemiology and Clinical Research, John Hopkins University, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Ciullo, Marina" sort="Ciullo, Marina" uniqKey="Ciullo M" first="Marina" last="Ciullo">Marina Ciullo</name><affiliation><nlm:aff id="A8">Institute of Genetics and Biophysics A. Buzzati-Traverso, Consiglio Nazionale delle Ricerche (CNR), Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S" last="Fox">Caroline S. Fox</name><affiliation><nlm:aff id="A9">National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A10">National Heart, Lung, and Blood Institute’s Center for Population Studies, Framingham, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A153">Division of Endocrinology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Caulfield, Mark" sort="Caulfield, Mark" uniqKey="Caulfield M" first="Mark" last="Caulfield">Mark Caulfield</name><affiliation><nlm:aff id="A77">William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name><affiliation><nlm:aff id="A154">University Institute of Social and Preventive Medicine, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation><nlm:aff id="A3">Institute of Genetic Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near <italic>TRIM46</italic>, <italic>INHBB</italic>, <italic>SFMBT1</italic>, <italic>TMEM171</italic>, <italic>VEGFA</italic>, <italic>BAZ1B</italic>, <italic>PRKAG2</italic>, <italic>STC1</italic>, <italic>HNF4G</italic>, <italic>A1CF</italic>, <italic>ATXN2</italic>, <italic>UBE2Q2</italic>, <italic>IGF1R</italic>, <italic>NFAT5</italic>, <italic>MAF</italic>, <italic>HLF</italic>, <italic>ACVR1B</italic>-<italic>ACVRL1</italic> and <italic>B3GNT4</italic>). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id><journal-id journal-id-type="pubmed-jr-id">2419</journal-id><journal-id journal-id-type="nlm-ta">Nat Genet</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Genet.</journal-id><journal-title-group><journal-title>Nature genetics</journal-title></journal-title-group><issn pub-type="ppub">1061-4036</issn><issn pub-type="epub">1546-1718</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23263486</article-id><article-id pub-id-type="pmc">3663712</article-id><article-id pub-id-type="doi">10.1038/ng.2500</article-id><article-id pub-id-type="manuscript">NIHMS458823</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Genome-wide association analyses identify 18 new loci associated with serum urate concentrations</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Köttgen</surname><given-names>Anna</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref rid="FN3" ref-type="author-notes">156</xref></contrib><contrib 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ref-type="author-notes">157</xref></contrib><contrib contrib-type="author"><name><surname>Fox</surname><given-names>Caroline S</given-names></name><xref ref-type="aff" rid="A9">9</xref><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A153">154</xref><xref rid="FN3" ref-type="author-notes">156</xref><xref rid="FN4" ref-type="author-notes">157</xref></contrib><contrib contrib-type="author"><name><surname>Caulfield</surname><given-names>Mark</given-names></name><xref ref-type="aff" rid="A77">77</xref><xref rid="FN3" ref-type="author-notes">156</xref><xref rid="FN4" ref-type="author-notes">157</xref></contrib><contrib contrib-type="author"><name><surname>Bochud</surname><given-names>Murielle</given-names></name><xref ref-type="aff" rid="A154">155</xref><xref rid="FN3" ref-type="author-notes">156</xref><xref rid="FN4" ref-type="author-notes">157</xref></contrib><contrib contrib-type="author"><name><surname>Gieger</surname><given-names>Christian</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref rid="FN3" ref-type="author-notes">156</xref><xref rid="FN4" ref-type="author-notes">157</xref></contrib></contrib-group><aff id="A1"><label>1</label>Renal Division, Freiburg University Hospital, Freiburg, Germany</aff><aff id="A2"><label>2</label>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA</aff><aff id="A3"><label>3</label>Institute of Genetic Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="A4"><label>4</label>Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany</aff><aff id="A5"><label>5</label>Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK</aff><aff id="A6"><label>6</label>Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="A7"><label>7</label>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy</aff><aff id="A8"><label>8</label>Institute of Genetics and Biophysics A. Buzzati-Traverso, Consiglio Nazionale delle Ricerche (CNR), Naples, Italy</aff><aff id="A9"><label>9</label>National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA</aff><aff id="A10"><label>10</label>National Heart, Lung, and Blood Institute’s Center for Population Studies, Framingham, Massachusetts, USA</aff><aff id="A11"><label>11</label>Renal Division, Massachusetts General Hospital, Boston, Massachusetts, USA</aff><aff id="A12"><label>12</label>Estonian Genome Center, University of Tartu, Tartu, Estonia</aff><aff id="A13"><label>13</label>Department of Biostatistics, Boston University, Boston, Massachusetts, USA</aff><aff id="A14"><label>14</label>Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA</aff><aff id="A15"><label>15</label>Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland</aff><aff id="A16"><label>16</label>Swiss Institute of Bioinformatics, Lausanne, Switzerland</aff><aff id="A17"><label>17</label>Icelandic Heart Association Research Institute, Kopavogur, Iceland</aff><aff id="A18"><label>18</label>Faculty of Medicine, University of Iceland, Reykjavik, Iceland</aff><aff id="A19"><label>19</label>University of Maryland School of Medicine, Baltimore, Maryland, USA</aff><aff id="A20"><label>20</label>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</aff><aff id="A21"><label>21</label>Department of Medicine, Prince Charles Hospital, Chermside, Queensland, Australia</aff><aff id="A22"><label>22</label>Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia</aff><aff id="A23"><label>23</label>Clinical Pharmacology Unit, University of Cambridge, Cambridge, UK</aff><aff id="A24"><label>24</label>Division of Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA</aff><aff id="A25"><label>25</label>Birmingham Veterans Affairs Medical Center, University of Alabama at Birmingham, Birmingham, Alabama, USA</aff><aff id="A26"><label>26</label>Institute for Maternal and Child Health, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Burlo Garofolo–Trieste, University of Trieste, Trieste, Italy</aff><aff id="A27"><label>27</label>Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA</aff><aff id="A28"><label>28</label>Faculty of Medicine, University of Split, Split, Croatia</aff><aff id="A29"><label>29</label>Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8199, Genomics and Molecular Physiology of Metabolic Diseases, Institut Pasteur de Lille, Lille, France</aff><aff id="A30"><label>30</label>CNRS UMR 8524, Laboratory of Mathematics, University Lille 1, Model for Data Analysis and Learning (MODAL) Team, Institut National de Recherche en Informatique et en Automatique (INRIA) Lille Nord–Europe, Lille, France</aff><aff id="A31"><label>31</label>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</aff><aff id="A32"><label>32</label>Subdivision of Genetic Epidemiology, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</aff><aff id="A33"><label>33</label>Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA</aff><aff id="A34"><label>34</label>Biology and Genetics Section, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy</aff><aff id="A35"><label>35</label>Department of Psychology, The University of Edinburgh, Edinburgh, UK</aff><aff id="A36"><label>36</label>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</aff><aff id="A37"><label>37</label>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A38"><label>38</label>Institute of Clinical Science, Faculty of Medicine, Imperial College London, London, UK</aff><aff id="A39"><label>39</label>Ludwigshafen Risk and Cardiovascular Health (LURIC) Study, Freiburg, Germany</aff><aff id="A40"><label>40</label>Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany</aff><aff id="A41"><label>41</label>Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck)</aff><aff id="A42"><label>42</label>Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A43"><label>43</label>Uppsala Clinical Research Center, Uppsala University Hospital, Uppsala, Sweden</aff><aff id="A44"><label>44</label>Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</aff><aff id="A45"><label>45</label>Institute of Population Genetics, CNR, Sassari, Italy</aff><aff id="A46"><label>46</label>Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, UK</aff><aff id="A47"><label>47</label>Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A48"><label>48</label>Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</aff><aff id="A49"><label>49</label>Member of Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands</aff><aff id="A50"><label>50</label>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Italy</aff><aff id="A51"><label>51</label>Roslin Institute, The University of Edinburgh, Edinburgh, UK</aff><aff id="A52"><label>52</label>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK</aff><aff id="A53"><label>53</label>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</aff><aff id="A54"><label>54</label>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</aff><aff id="A55"><label>55</label>King’s College London, St Thomas’ Hospital Campus, London, UK</aff><aff id="A56"><label>56</label>Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA</aff><aff id="A57"><label>57</label>Fimlab Laboratories, University of Tampere and Tampere University Hospital, Tampere, Finland</aff><aff id="A58"><label>58</label>Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</aff><aff id="A59"><label>59</label>Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, Tokyo, Japan</aff><aff id="A60"><label>60</label>Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan</aff><aff id="A61"><label>61</label>University Heart Center Hamburg, Clinic for General and Interventional Cardiology, Hamburg, Germany</aff><aff id="A62"><label>62</label>School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia</aff><aff id="A63"><label>63</label>Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</aff><aff id="A64"><label>64</label>Max Planck Institute of Psychiatry, Munich, Germany</aff><aff id="A65"><label>65</label>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</aff><aff id="A66"><label>66</label>Swiss Tropical and Public Health Institute, Basel, Switzerland</aff><aff id="A67"><label>67</label>University of Basel, Basel, Switzerland</aff><aff id="A68"><label>68</label>Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany</aff><aff id="A69"><label>69</label>Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland, USA</aff><aff id="A70"><label>70</label>University of Texas Health Science Center at Houston, Houston, Texas, USA</aff><aff id="A71"><label>71</label>Welch Center for Prevention, Epidemiology and Clinical Research, John Hopkins University, Baltimore, Maryland, USA</aff><aff id="A72"><label>72</label>Institute of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria</aff><aff id="A73"><label>73</label>Department of Neurology, Section of Special Neurology, Medical University Graz, Graz, Austria</aff><aff id="A74"><label>74</label>Laboratory for Genotyping Development, Center for Genomic Medicine, RIKEN, Yokohama, Japan</aff><aff id="A75"><label>75</label>Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan</aff><aff id="A76"><label>76</label>Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan</aff><aff id="A77"><label>77</label>William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</aff><aff id="A78"><label>78</label>Leicester National Institute for Health Research (NIHR) Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, UK</aff><aff id="A79"><label>79</label>Department of Cardiovascular Sciences, University of Leicester, Leicester, UK</aff><aff id="A80"><label>80</label>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA</aff><aff id="A81"><label>81</label>Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA</aff><aff id="A82"><label>82</label>Intitute for Maternal and Child Health, IRCCS Burlo Garofolo–Trieste, Trieste, Italy</aff><aff id="A83"><label>83</label>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</aff><aff id="A84"><label>84</label>Department of Epidemiology, University of Washington, Seattle, Washington, USA</aff><aff id="A85"><label>85</label>Department of Medicine, University of Washington, Seattle, Washington, USA</aff><aff id="A86"><label>86</label>Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA</aff><aff id="A87"><label>87</label>Department of Health Services, University of Washington, Seattle, Washington, USA</aff><aff id="A88"><label>88</label>Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland</aff><aff id="A89"><label>89</label>Institute of Physiology, Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland</aff><aff id="A90"><label>90</label>Unité Mixte de Recherche en Santé (UMRS) 1018, University Paris Sud 11, Villejuif, France</aff><aff id="A91"><label>91</label>Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK</aff><aff id="A92"><label>92</label>Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia</aff><aff id="A93"><label>93</label>Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia</aff><aff id="A94"><label>94</label>Clinical Gerontology Unit, Addenbrooke’s Hospital, Cambridge, UK</aff><aff id="A95"><label>95</label>Center for Thrombosis and Hemostasis, University Medical Center Mainz, Johannes Gutenberg University Mainz, Mainz, Germany</aff><aff id="A96"><label>96</label>Department of Medicine II, University Medical Center Mainz, Johannes Gutenberg University Mainz, Mainz, Germany</aff><aff id="A97"><label>97</label>School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia</aff><aff id="A98"><label>98</label>Chair of Medical Physics, Department of Biomedical Engineering, Tallinn University of Technology, Tallinn, Estonia</aff><aff id="A99"><label>99</label>Centre of Cardiology, North Estonia Medical Centre, Tallinn, Estonia</aff><aff id="A100"><label>100</label>Geniatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</aff><aff id="A101"><label>101</label>Division of Nephrology, Department of Medicine, University of Verona, Verona, Italy</aff><aff id="A102"><label>102</label>Institute of Epidemiology II, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="A103"><label>103</label>Institute of Epidemiology I, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="A104"><label>104</label>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="A105"><label>105</label>Chair of Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University, Munich, Germany</aff><aff id="A106"><label>106</label>Chair of Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University, Munich, Germany</aff><aff id="A107"><label>107</label>Klinikum Grosshadern, Munich, Germany</aff><aff id="A108"><label>108</label>University Medical Center Groningen, LifeLines Department, University of Groningen, Groningen, The Netherlands</aff><aff id="A109"><label>110</label>Faculty of Medicine, National Heart & Lung Institute, Cardiovascular Science, Hammersmith Hospital, Hammersmith Campus, Imperial College London, London, UK</aff><aff id="A110"><label>111</label>Cath Laboratory, Cardiology, Ealing Hospital, Southall, UK</aff><aff id="A111"><label>112</label>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK</aff><aff id="A112"><label>113</label>ClinPhenomics Study Center, Frankfurt, Germany</aff><aff id="A113"><label>114</label>Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, Ulm, Germany</aff><aff id="A114"><label>115</label>Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands</aff><aff id="A115"><label>116</label>Department of Psychiatry, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A116"><label>117</label>Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="A117"><label>118</label>Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA</aff><aff id="A118"><label>119</label>Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, Massachusetts, USA</aff><aff id="A119"><label>120</label>Division of Genetics, Brigham and Women’s Hospital, Boston, Massachusetts, USA</aff><aff id="A120"><label>121</label>Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA</aff><aff id="A121"><label>122</label>Division of Experimental Cardiology, Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A122"><label>123</label>Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</aff><aff id="A123"><label>124</label>Institute of Clinical Chemistry, University Hospital of Zurich, Zurich, Switzerland</aff><aff id="A124"><label>125</label>Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA</aff><aff id="A125"><label>126</label>Medical Department, University of Leipzig, Leipzig, Germany</aff><aff id="A126"><label>127</label>Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany</aff><aff id="A127"><label>128</label>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland</aff><aff id="A128"><label>129</label>Institute of Molecular Medicine, University of Helsinki, Helsinki, Finland</aff><aff id="A129"><label>130</label>Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK</aff><aff id="A130"><label>131</label>Harvard Medical School, Boston, Massachusetts, USA</aff><aff id="A131"><label>132</label>Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland</aff><aff id="A132"><label>133</label>Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland</aff><aff id="A133"><label>134</label>Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany</aff><aff id="A134"><label>135</label>Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA</aff><aff id="A135"><label>136</label>Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA</aff><aff id="A136"><label>137</label>Imperial College Cerebrovascular Research Unit, Imperial College London, London, UK</aff><aff id="A137"><label>138</label>Laboratory for International Alliance, Center for Genomic Medicine, RIKEN, Yokohama, Japan</aff><aff id="A138"><label>139</label>Nephrology Division, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland</aff><aff id="A139"><label>140</label>Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts, USA</aff><aff id="A140"><label>141</label>Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Massachusetts, USA</aff><aff id="A141"><label>142</label>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany</aff><aff id="A142"><label>143</label>University of Texas–Houston Institute of Molecular Medicine, Houston, Texas, USA</aff><aff id="A143"><label>144</label>University of Texas–Houston School of Public Health, Houston, Texas, USA</aff><aff id="A144"><label>145</label>Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA</aff><aff id="A145"><label>146</label>Renal Program, Institute of Internal Medicine, Columbus-Gemelli University Hospital, Catholic University, Rome, Italy</aff><aff id="A146"><label>147</label>Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A147"><label>148</label>Synlab Centre of Laboratory Diagnostics, Heidelberg, Germany</aff><aff id="A148"><label>149</label>Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A149"><label>150</label>On behalf of PROCARDIS</aff><aff id="A150"><label>151</label>Institute of Molecular Genetics, CNR, Pavia, Italy</aff><aff id="A151"><label>152</label>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland</aff><aff id="A152"><label>153</label>Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland</aff><aff id="A153"><label>154</label>Division of Endocrinology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</aff><aff id="A154"><label>155</label>University Institute of Social and Preventive Medicine, Lausanne, Switzerland</aff><author-notes><corresp id="FN1">Correspondence should be addressed to A. Köttgen (<email>anna.koettgen@uniklinik-freiburg.de</email>), V.V. (<email>veronique.vitart@igmm.ed.ac.uk</email>), M. Bochud (<email>murielle.bochud@chuv.ch</email>) or C.G. (<email>christian.gieger@helmholtz-muenchen.de</email>)</corresp><fn id="FN2"><label>109</label><p>A list of contributing members appears in the <xref rid="SD1" ref-type="supplementary-material">Supplementary Note</xref>.</p></fn><fn id="FN3" fn-type="equal"><label>156</label><p>These authors contributed equally to this work.</p></fn><fn id="FN4"><label>157</label><p>These authors jointly directed this work.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>2</day><month>5</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>23</day><month>12</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>2</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>8</month><year>2013</year></pub-date><volume>45</volume><issue>2</issue><fpage>145</fpage><lpage>154</lpage><permissions><copyright-statement>© 2013 Nature America, Inc. All rights reserved.</copyright-statement><copyright-year>2013</copyright-year></permissions><abstract><p id="P1">Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near <italic>TRIM46</italic>, <italic>INHBB</italic>, <italic>SFMBT1</italic>, <italic>TMEM171</italic>, <italic>VEGFA</italic>, <italic>BAZ1B</italic>, <italic>PRKAG2</italic>, <italic>STC1</italic>, <italic>HNF4G</italic>, <italic>A1CF</italic>, <italic>ATXN2</italic>, <italic>UBE2Q2</italic>, <italic>IGF1R</italic>, <italic>NFAT5</italic>, <italic>MAF</italic>, <italic>HLF</italic>, <italic>ACVR1B</italic>-<italic>ACVRL1</italic> and <italic>B3GNT4</italic>). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout.</p></abstract><funding-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>N02HL64278 || HL</award-id></award-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>N01HC85086 || HL</award-id></award-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>N01HC85079 || HL</award-id></award-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>N01HC75150 || HL</award-id></award-group><award-group><funding-source country="United States">National Heart, Lung, and Blood 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