A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
Identifieur interne : 002134 ( Pmc/Corpus ); précédent : 002133; suivant : 002135A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
Auteurs : Alisa K. Manning ; Marie-France Hivert ; Robert A. Scott ; Jonna L. Grimsby ; Nabila Bouatia-Naji ; Han Chen ; Denis Rybin ; Ching-Ti Liu ; Lawrence F. Bielak ; Inga Prokopenko ; Najaf Amin ; Daniel Barnes ; Gemma Cadby ; Jouke-Jan Hottenga ; Erik Ingelsson ; Anne U. Jackson ; Toby Johnson ; Stavroula Kanoni ; Claes Ladenvall ; Vasiliki Lagou ; Jari Lahti ; Cecile Lecoeur ; Yongmei Liu ; Maria Teresa Martinez-Larrad ; May E. Montasser ; Pau Navarro ; John R. B. Perry ; Laura J. Rasmussen-Torvik ; Perttu Salo ; Naveed Sattar ; Dmitry Shungin ; Rona J. Strawbridge ; Toshiko Tanaka ; Cornelia M. Van Duijn ; Ping An ; Mariza De Andrade ; Jeanette S. Andrews ; Thor Aspelund ; Mustafa Atalay ; Yurii Aulchenko ; Beverley Balkau ; Stefania Bandinelli ; Jacques S. Beckmann ; John P. Beilby ; Claire Bellis ; Richard N. Bergman ; John Blangero ; Mladen Boban ; Michael Boehnke ; Eric Boerwinkle ; Lori L. Bonnycastle ; Dorret I. Boomsma ; Ingrid B. Borecki ; Yvonne Böttcher ; Claude Bouchard ; Eric Brunner ; Danijela Budimir ; Harry Campbell ; Olga Carlson ; Peter S. Chines ; Robert Clarke ; Francis S. Collins ; Arturo Corbat N-Anchuelo ; David Couper ; Ulf De Faire ; George V. Dedoussis ; Panos Deloukas ; Maria Dimitriou ; Josephine M. Egan ; Gudny Eiriksdottir ; Michael R. Erdos ; Johan G. Eriksson ; Elodie Eury ; Luigi Ferrucci ; Ian Ford ; Nita G. Forouhi ; Caroline S. Fox ; Maria Grazia Franzosi ; Paul W. Franks ; Timothy M. Frayling ; Philippe Froguel ; Pilar Galan ; Eco De Geus ; Bruna Gigante ; Nicole L. Glazer ; Anuj Goel ; Leif Groop ; Vilmundur Gudnason ; Göran Hallmans ; Anders Hamsten ; Ola Hansson ; Tamara B. Harris ; Caroline Hayward ; Simon Heath ; Serge Hercberg ; Andrew A. Hicks ; Aroon Hingorani ; Albert Hofman ; Jennie Hui ; Joseph Hung ; Marjo Riitta Jarvelin ; Min A. Jhun ; Paul C. D. Johnson ; J Wouter Jukema ; Antti Jula ; W. H. Kao ; Jaakko Kaprio ; Sharon L. R. Kardia ; Sirkka Keinanen-Kiukaanniemi ; Mika Kivimaki ; Ivana Kolcic ; Peter Kovacs ; Meena Kumari ; Johanna Kuusisto ; Kirsten Ohm Kyvik ; Markku Laakso ; Timo Lakka ; Lars Lannfelt ; G Mark Lathrop ; Lenore J. Launer ; Karin Leander ; Guo Li ; Lars Lind ; Jaana Lindstrom ; Stéphane Lobbens ; Ruth J. F. Loos ; Jian N Luan ; Valeriya Lyssenko ; Reedik M Gi ; Patrik K. E. Magnusson ; Michael Marmot ; Pierre Meneton ; Karen L. Mohlke ; Vincent Mooser ; Mario A. Morken ; Iva Miljkovic ; Narisu Narisu ; Jeff O Onnell ; Ken K. Ong ; Ben A. Oostra ; Lyle J. Palmer ; Aarno Palotie ; James S. Pankow ; John F. Peden ; Nancy L. Pedersen ; Marina Pehlic ; Leena Peltonen ; Brenda Penninx ; Marijana Pericic ; Markus Perola ; Louis Perusse ; Patricia A. Peyser ; Ozren Polasek ; Peter P. Pramstaller ; Michael A. Province ; Katri R Ikkönen ; Rainer Rauramaa ; Emil Rehnberg ; Ken Rice ; Jerome I. Rotter ; Igor Rudan ; Aimo Ruokonen ; Timo Saaristo ; Maria Sabater-Lleal ; Veikko Salomaa ; David B. Savage ; Richa Saxena ; Peter Schwarz ; Udo Seedorf ; Bengt Sennblad ; Manuel Serrano-Rios ; Alan R. Shuldiner ; Eric J. G. Sijbrands ; David S. Siscovick ; Johannes H. Smit ; Kerrin S. Small ; Nicholas L. Smith ; Albert Vernon Smith ; Alena Stan Ková ; Kathleen Stirrups ; Michael Stumvoll ; Yan V. Sun ; Amy J. Swift ; Anke Tönjes ; Jaakko Tuomilehto ; Stella Trompet ; Andre G. Uitterlinden ; Matti Uusitupa ; Max Vikström ; Veronique Vitart ; Marie-Claude Vohl ; Benjamin F. Voight ; Peter Vollenweider ; Gerard Waeber ; Dawn M. Waterworth ; Hugh Watkins ; Eleanor Wheeler ; Elisabeth Widen ; Sarah H. Wild ; Sara M. Willems ; Gonneke Willemsen ; James F. Wilson ; Jacqueline C. M. Witteman ; Alan F. Wright ; Hanieh Yaghootkar ; Diana Zelenika ; Tatijana Zemunik ; Lina Zgaga ; Nicholas J. Wareham ; Mark I. Mccarthy ; Ines Barroso ; Richard M. Watanabe ; Jose C. Florez ; Josée Dupuis ; James B. Meigs ; Claudia LangenbergSource :
- Nature genetics [ 1061-4036 ] ; 2012.
Abstract
Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and beta-cell dysfunction, but contributed little to our understanding of the genetic basis of insulin resistance. We hypothesized that genes implicated in insulin resistance pathways may be uncovered by accounting for differences in body mass index (BMI) and potential interaction between BMI and genetic variants. We applied a novel joint meta-analytical approach to test associations with fasting insulin (FI) and glucose (FG) on a genome-wide scale. We present six previously unknown FI loci at
Url:
DOI: 10.1038/ng.2274
PubMed: 22581228
PubMed Central: 3613127
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PMC:3613127Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance</title><author><name sortKey="Manning, Alisa K" sort="Manning, Alisa K" uniqKey="Manning A" first="Alisa K." last="Manning">Alisa K. Manning</name><affiliation><nlm:aff id="A1">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Harvard Medical School, Boston, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Hivert, Marie France" sort="Hivert, Marie France" uniqKey="Hivert M" first="Marie-France" last="Hivert">Marie-France Hivert</name><affiliation><nlm:aff id="A5">General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Department of Medicine, Universite de Sherbrooke, Sherbrooke, Québec, Canada</nlm:aff></affiliation></author><author><name sortKey="Scott, Robert A" sort="Scott, Robert A" uniqKey="Scott R" first="Robert A." last="Scott">Robert A. Scott</name><affiliation><nlm:aff id="A7">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Grimsby, Jonna L" sort="Grimsby, Jonna L" uniqKey="Grimsby J" first="Jonna L." last="Grimsby">Jonna L. Grimsby</name><affiliation><nlm:aff id="A5">General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name><affiliation><nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Lille Nord de France University, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Chen, Han" sort="Chen, Han" uniqKey="Chen H" first="Han" last="Chen">Han Chen</name><affiliation><nlm:aff id="A1">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Rybin, Denis" sort="Rybin, Denis" uniqKey="Rybin D" first="Denis" last="Rybin">Denis Rybin</name><affiliation><nlm:aff id="A11">Boston University Data Coordinating Center, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Liu, Ching Ti" sort="Liu, Ching Ti" uniqKey="Liu C" first="Ching-Ti" last="Liu">Ching-Ti Liu</name><affiliation><nlm:aff id="A1">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Bielak, Lawrence F" sort="Bielak, Lawrence F" uniqKey="Bielak L" first="Lawrence F." last="Bielak">Lawrence F. Bielak</name><affiliation><nlm:aff id="A12">Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation><nlm:aff id="A13">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation><nlm:aff id="A15">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Barnes, Daniel" sort="Barnes, Daniel" uniqKey="Barnes D" first="Daniel" last="Barnes">Daniel Barnes</name><affiliation><nlm:aff id="A7">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Cadby, Gemma" sort="Cadby, Gemma" uniqKey="Cadby G" first="Gemma" last="Cadby">Gemma Cadby</name><affiliation><nlm:aff id="A16">Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research. Toronto, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation><nlm:aff id="A18">Netherlands Twin Register, Department of Biological Psychology, VU University, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation><nlm:aff id="A19">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Jackson, Anne U" sort="Jackson, Anne U" uniqKey="Jackson A" first="Anne U." last="Jackson">Anne U. Jackson</name><affiliation><nlm:aff id="A20">Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name><affiliation><nlm:aff id="A21">Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kanoni, Stavroula" sort="Kanoni, Stavroula" uniqKey="Kanoni S" first="Stavroula" last="Kanoni">Stavroula Kanoni</name><affiliation><nlm:aff id="A22">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hixton, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Ladenvall, Claes" sort="Ladenvall, Claes" uniqKey="Ladenvall C" first="Claes" last="Ladenvall">Claes Ladenvall</name><affiliation><nlm:aff id="A23">Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Lund University Diabetes Centre, Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lagou, Vasiliki" sort="Lagou, Vasiliki" uniqKey="Lagou V" first="Vasiliki" last="Lagou">Vasiliki Lagou</name><affiliation><nlm:aff id="A13">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><affiliation><nlm:aff id="A25">Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Lecoeur, Cecile" sort="Lecoeur, Cecile" uniqKey="Lecoeur C" first="Cecile" last="Lecoeur">Cecile Lecoeur</name><affiliation><nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Lille Nord de France University, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation><nlm:aff id="A26">Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA</nlm:aff></affiliation></author><author><name sortKey="Martinez Larrad, Maria Teresa" sort="Martinez Larrad, Maria Teresa" uniqKey="Martinez Larrad M" first="Maria Teresa" last="Martinez-Larrad">Maria Teresa Martinez-Larrad</name><affiliation><nlm:aff id="A27">Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Montasser, May E" sort="Montasser, May E" uniqKey="Montasser M" first="May E." last="Montasser">May E. Montasser</name><affiliation><nlm:aff id="A28">Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Navarro, Pau" sort="Navarro, Pau" uniqKey="Navarro P" first="Pau" last="Navarro">Pau Navarro</name><affiliation><nlm:aff id="A29">MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Perry, John R B" sort="Perry, John R B" uniqKey="Perry J" first="John R. B." last="Perry">John R. B. Perry</name><affiliation><nlm:aff id="A14">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Rasmussen Torvik, Laura J" sort="Rasmussen Torvik, Laura J" uniqKey="Rasmussen Torvik L" first="Laura J." last="Rasmussen-Torvik">Laura J. Rasmussen-Torvik</name><affiliation><nlm:aff id="A32">Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA</nlm:aff></affiliation></author><author><name sortKey="Salo, Perttu" sort="Salo, Perttu" uniqKey="Salo P" first="Perttu" last="Salo">Perttu Salo</name><affiliation><nlm:aff id="A33">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name><affiliation><nlm:aff id="A34">Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Shungin, Dmitry" sort="Shungin, Dmitry" uniqKey="Shungin D" first="Dmitry" last="Shungin">Dmitry Shungin</name><affiliation><nlm:aff id="A23">Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Lund University Diabetes Centre, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A35">Department of Public Health & Clinical Medicine, Genetic Epidemiology & Clinical Research Group, Umeå University Hospital, Umeå, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Department of Odontology, Umeå University, Sweden</nlm:aff></affiliation></author><author><name sortKey="Strawbridge, Rona J" sort="Strawbridge, Rona J" uniqKey="Strawbridge R" first="Rona J." last="Strawbridge">Rona J. Strawbridge</name><affiliation><nlm:aff id="A37">Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation><nlm:aff id="A38">Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A15">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Centre for medical systems biology, Netherlands Genomics Initiative, The Hague</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Netherlands Genomics Initiative and the Netherlands Consortium for Healthy Aging, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="An, Ping" sort="An, Ping" uniqKey="An P" first="Ping" last="An">Ping An</name><affiliation><nlm:aff id="A41">Department of Genetics Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="De Andrade, Mariza" sort="De Andrade, Mariza" uniqKey="De Andrade M" first="Mariza" last="De Andrade">Mariza De Andrade</name><affiliation><nlm:aff id="A42">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Andrews, Jeanette S" sort="Andrews, Jeanette S" uniqKey="Andrews J" first="Jeanette S." last="Andrews">Jeanette S. Andrews</name><affiliation><nlm:aff id="A43">Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA</nlm:aff></affiliation></author><author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name><affiliation><nlm:aff id="A44">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A45">University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Atalay, Mustafa" sort="Atalay, Mustafa" uniqKey="Atalay M" first="Mustafa" last="Atalay">Mustafa Atalay</name><affiliation><nlm:aff id="A46">Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Aulchenko, Yurii" sort="Aulchenko, Yurii" uniqKey="Aulchenko Y" first="Yurii" last="Aulchenko">Yurii Aulchenko</name><affiliation><nlm:aff id="A15">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><affiliation><nlm:aff id="A47">Inserm, CESP Centre for research in Epidemiology and Population Health, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A48">University Paris Sud 11, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name><affiliation><nlm:aff id="A49">Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Jacques S" sort="Beckmann, Jacques S" uniqKey="Beckmann J" first="Jacques S." last="Beckmann">Jacques S. Beckmann</name><affiliation><nlm:aff id="A50">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A51">Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Beilby, John P" sort="Beilby, John P" uniqKey="Beilby J" first="John P." last="Beilby">John P. Beilby</name><affiliation><nlm:aff id="A52">PathWest Laboratory Medicine of WA, J Block, QEII Medical Centre, Nedlands, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A53">School of Pathology and Laboratory Medicine, The University of Western Australia, Nedlands, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Busselton Population Medical Research Foundation, B Block, QEII Medical Centre, Nedlands, Australia</nlm:aff></affiliation></author><author><name sortKey="Bellis, Claire" sort="Bellis, Claire" uniqKey="Bellis C" first="Claire" last="Bellis">Claire Bellis</name><affiliation><nlm:aff id="A55">Texas Biomedical Research Institute, San Antonio, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Bergman, Richard N" sort="Bergman, Richard N" uniqKey="Bergman R" first="Richard N." last="Bergman">Richard N. Bergman</name><affiliation><nlm:aff id="A56">Department of Physiology & Biophysics, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Blangero, John" sort="Blangero, John" uniqKey="Blangero J" first="John" last="Blangero">John Blangero</name><affiliation><nlm:aff id="A55">Texas Biomedical Research Institute, San Antonio, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Boban, Mladen" sort="Boban, Mladen" uniqKey="Boban M" first="Mladen" last="Boban">Mladen Boban</name><affiliation><nlm:aff id="A57">Department of Pharmacology, Faculty of Medicine, University of Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Boehnke, Michael" sort="Boehnke, Michael" uniqKey="Boehnke M" first="Michael" last="Boehnke">Michael Boehnke</name><affiliation><nlm:aff id="A20">Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation><nlm:aff id="A58">Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Bonnycastle, Lori L" sort="Bonnycastle, Lori L" uniqKey="Bonnycastle L" first="Lori L." last="Bonnycastle">Lori L. Bonnycastle</name><affiliation><nlm:aff id="A59">Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:aff id="A18">Netherlands Twin Register, Department of Biological Psychology, VU University, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Borecki, Ingrid B" sort="Borecki, Ingrid B" uniqKey="Borecki I" first="Ingrid B." last="Borecki">Ingrid B. Borecki</name><affiliation><nlm:aff id="A41">Department of Genetics Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="Bottcher, Yvonne" sort="Bottcher, Yvonne" uniqKey="Bottcher Y" first="Yvonne" last="Böttcher">Yvonne Böttcher</name><affiliation><nlm:aff id="A60">IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Bouchard, Claude" sort="Bouchard, Claude" uniqKey="Bouchard C" first="Claude" last="Bouchard">Claude Bouchard</name><affiliation><nlm:aff id="A61">Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA</nlm:aff></affiliation></author><author><name sortKey="Brunner, Eric" sort="Brunner, Eric" uniqKey="Brunner E" first="Eric" last="Brunner">Eric Brunner</name><affiliation><nlm:aff id="A62">University College London, Department of Epidemiology & Public Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Budimir, Danijela" sort="Budimir, Danijela" uniqKey="Budimir D" first="Danijela" last="Budimir">Danijela Budimir</name><affiliation><nlm:aff id="A57">Department of Pharmacology, Faculty of Medicine, University of Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="A63">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Carlson, Olga" sort="Carlson, Olga" uniqKey="Carlson O" first="Olga" last="Carlson">Olga Carlson</name><affiliation><nlm:aff id="A64">Laboratory of Clinical Investigation, National Institute of Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Chines, Peter S" sort="Chines, Peter S" uniqKey="Chines P" first="Peter S." last="Chines">Peter S. Chines</name><affiliation><nlm:aff id="A59">Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name><affiliation><nlm:aff id="A65">Clinical Trial Service Unit, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Collins, Francis S" sort="Collins, Francis S" uniqKey="Collins F" first="Francis S." last="Collins">Francis S. Collins</name><affiliation><nlm:aff id="A66">Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Corbat N Anchuelo, Arturo" sort="Corbat N Anchuelo, Arturo" uniqKey="Corbat N Anchuelo A" first="Arturo" last="Corbat N-Anchuelo">Arturo Corbat N-Anchuelo</name><affiliation><nlm:aff id="A27">Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Couper, David" sort="Couper, David" uniqKey="Couper D" first="David" last="Couper">David Couper</name><affiliation><nlm:aff id="A67">Department of Biostatistics, University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina, USA</nlm:aff></affiliation></author><author><name sortKey="De Faire, Ulf" sort="De Faire, Ulf" uniqKey="De Faire U" first="Ulf" last="De Faire">Ulf De Faire</name><affiliation><nlm:aff id="A68">Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Dedoussis, George V" sort="Dedoussis, George V" uniqKey="Dedoussis G" first="George V" last="Dedoussis">George V. Dedoussis</name><affiliation><nlm:aff id="A69">Department of Nutrition - Dietetics, Harokopio University, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name><affiliation><nlm:aff id="A22">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hixton, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Dimitriou, Maria" sort="Dimitriou, Maria" uniqKey="Dimitriou M" first="Maria" last="Dimitriou">Maria Dimitriou</name><affiliation><nlm:aff id="A69">Department of Nutrition - Dietetics, Harokopio University, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Egan, Josephine M" sort="Egan, Josephine M" uniqKey="Egan J" first="Josephine M" last="Egan">Josephine M. Egan</name><affiliation><nlm:aff id="A64">Laboratory of Clinical Investigation, National Institute of Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation><nlm:aff id="A44">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation></author><author><name sortKey="Erdos, Michael R" sort="Erdos, Michael R" uniqKey="Erdos M" first="Michael R." last="Erdos">Michael R. Erdos</name><affiliation><nlm:aff id="A59">Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G." last="Eriksson">Johan G. Eriksson</name><affiliation><nlm:aff id="A70">Department of General Practice and Primary health Care, University of Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A71">Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Folkhalsan Research Centre, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Vaasa Central Hospital, Vaasa, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A74">National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Eury, Elodie" sort="Eury, Elodie" uniqKey="Eury E" first="Elodie" last="Eury">Elodie Eury</name><affiliation><nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Lille Nord de France University, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation><nlm:aff id="A75">Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name><affiliation><nlm:aff id="A76">Robertson Centre for Biostatistics, University of Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Forouhi, Nita G" sort="Forouhi, Nita G" uniqKey="Forouhi N" first="Nita G." last="Forouhi">Nita G. Forouhi</name><affiliation><nlm:aff id="A7">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S" last="Fox">Caroline S. Fox</name><affiliation><nlm:aff id="A77">National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A78">Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Franzosi, Maria Grazia" sort="Franzosi, Maria Grazia" uniqKey="Franzosi M" first="Maria Grazia" last="Franzosi">Maria Grazia Franzosi</name><affiliation><nlm:aff id="A79">Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Franks, Paul W" sort="Franks, Paul W" uniqKey="Franks P" first="Paul W" last="Franks">Paul W. Franks</name><affiliation><nlm:aff id="A23">Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Lund University Diabetes Centre, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A35">Department of Public Health & Clinical Medicine, Genetic Epidemiology & Clinical Research Group, Umeå University Hospital, Umeå, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A80">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A81">Institut National de la Recherche Agronomique, Université Paris, Bobigny Cedex, France</nlm:aff></affiliation></author><author><name sortKey="Frayling, Timothy M" sort="Frayling, Timothy M" uniqKey="Frayling T" first="Timothy M" last="Frayling">Timothy M. Frayling</name><affiliation><nlm:aff id="A30">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Lille Nord de France University, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A82">Genomic Medicine, Hammersmith Hospital, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name><affiliation><nlm:aff id="A83">Institut National de la Santé et de la Recherche Médicale, Université Paris, Bobigny Cedex, France</nlm:aff></affiliation></author><author><name sortKey="De Geus, Eco" sort="De Geus, Eco" uniqKey="De Geus E" first="Eco" last="De Geus">Eco De Geus</name><affiliation><nlm:aff id="A18">Netherlands Twin Register, Department of Biological Psychology, VU University, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Gigante, Bruna" sort="Gigante, Bruna" uniqKey="Gigante B" first="Bruna" last="Gigante">Bruna Gigante</name><affiliation><nlm:aff id="A68">Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Glazer, Nicole L" sort="Glazer, Nicole L" uniqKey="Glazer N" first="Nicole L." last="Glazer">Nicole L. Glazer</name><affiliation><nlm:aff id="A84">Department of Medicine, Section of Preventive Medicine and Epidemiology, BU School of Medicine, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A85">Department of Epidemiology, BU School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name><affiliation><nlm:aff id="A86">Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Groop, Leif" sort="Groop, Leif" uniqKey="Groop L" first="Leif" last="Groop">Leif Groop</name><affiliation><nlm:aff id="A23">Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Lund University Diabetes Centre, Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="A44">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A45">University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Hallmans, Goran" sort="Hallmans, Goran" uniqKey="Hallmans G" first="Göran" last="Hallmans">Göran Hallmans</name><affiliation><nlm:aff id="A87">Department of Public Health & Clinical Medicine, Nutrition Research, Umeå University, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name><affiliation><nlm:aff id="A37">Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hansson, Ola" sort="Hansson, Ola" uniqKey="Hansson O" first="Ola" last="Hansson">Ola Hansson</name><affiliation><nlm:aff id="A23">Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Lund University Diabetes Centre, Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="A88">Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="A29">MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Heath, Simon" sort="Heath, Simon" uniqKey="Heath S" first="Simon" last="Heath">Simon Heath</name><affiliation><nlm:aff id="A89">Centre National de Génotypage, Commissariat à L’Energie Atomique, Institut de Génomique, Evry, France</nlm:aff></affiliation></author><author><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name><affiliation><nlm:aff id="A83">Institut National de la Santé et de la Recherche Médicale, Université Paris, Bobigny Cedex, France</nlm:aff></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A." last="Hicks">Andrew A. Hicks</name><affiliation><nlm:aff id="A90">Center for Biomedicine, European Academy Bozen/Bolzano, Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Hingorani, Aroon" sort="Hingorani, Aroon" uniqKey="Hingorani A" first="Aroon" last="Hingorani">Aroon Hingorani</name><affiliation><nlm:aff id="A91">Genetic epidemiology group, University College London, Department of Epidemiology & Public Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A15">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Netherlands Genomics Initiative and the Netherlands Consortium for Healthy Aging, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hui, Jennie" sort="Hui, Jennie" uniqKey="Hui J" first="Jennie" last="Hui">Jennie Hui</name><affiliation><nlm:aff id="A52">PathWest Laboratory Medicine of WA, J Block, QEII Medical Centre, Nedlands, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A53">School of Pathology and Laboratory Medicine, The University of Western Australia, Nedlands, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Busselton Population Medical Research Foundation, B Block, QEII Medical Centre, Nedlands, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A92">School of Population Health, The University of Western Australia, Nedlands, Australia</nlm:aff></affiliation></author><author><name sortKey="Hung, Joseph" sort="Hung, Joseph" uniqKey="Hung J" first="Joseph" last="Hung">Joseph Hung</name><affiliation><nlm:aff id="A54">Busselton Population Medical Research Foundation, B Block, QEII Medical Centre, Nedlands, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A93">Sir Charles Gairdner Hospital Unit, School of Medicine & Pharmacology, University of Western Australia, Australia</nlm:aff></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo Riitta" last="Jarvelin">Marjo Riitta Jarvelin</name><affiliation><nlm:aff id="A94">Department of Epidemiology and Biostatistics, School of Public Health, MRC-HPA Centre for Environment and Health, Faculty of Medicine, Imperial College London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A95">Institute of Health Sciences, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A96">Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A97">National Institute of Health and Welfare, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Jhun, Min A" sort="Jhun, Min A" uniqKey="Jhun M" first="Min A." last="Jhun">Min A. Jhun</name><affiliation><nlm:aff id="A12">Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Johnson, Paul C D" sort="Johnson, Paul C D" uniqKey="Johnson P" first="Paul C. D." last="Johnson">Paul C. D. Johnson</name><affiliation><nlm:aff id="A76">Robertson Centre for Biostatistics, University of Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J Wouter" last="Jukema">J Wouter Jukema</name><affiliation><nlm:aff id="A98">Department of Cardiology C5-P, Leiden University Medical Center, Leiden, the Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A99">Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Jula, Antti" sort="Jula, Antti" uniqKey="Jula A" first="Antti" last="Jula">Antti Jula</name><affiliation><nlm:aff id="A33">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kao, W H" sort="Kao, W H" uniqKey="Kao W" first="W. H." last="Kao">W. H. Kao</name><affiliation><nlm:aff id="A100">Division of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation><nlm:aff id="A74">National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A101">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A102">Hjelt Institute, Dept of Public Health, University of Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kardia, Sharon L R" sort="Kardia, Sharon L R" uniqKey="Kardia S" first="Sharon L. R." last="Kardia">Sharon L. R. Kardia</name><affiliation><nlm:aff id="A12">Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Keinanen Kiukaanniemi, Sirkka" sort="Keinanen Kiukaanniemi, Sirkka" uniqKey="Keinanen Kiukaanniemi S" first="Sirkka" last="Keinanen-Kiukaanniemi">Sirkka Keinanen-Kiukaanniemi</name><affiliation><nlm:aff id="A103">Faculty of Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A104">Unit of General Practice, Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name><affiliation><nlm:aff id="A62">University College London, Department of Epidemiology & Public Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name><affiliation><nlm:aff id="A105">Department of Public Health, Faculty of Medicine, University of Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Kovacs, Peter" sort="Kovacs, Peter" uniqKey="Kovacs P" first="Peter" last="Kovacs">Peter Kovacs</name><affiliation><nlm:aff id="A106">Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name><affiliation><nlm:aff id="A91">Genetic epidemiology group, University College London, Department of Epidemiology & Public Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kuusisto, Johanna" sort="Kuusisto, Johanna" uniqKey="Kuusisto J" first="Johanna" last="Kuusisto">Johanna Kuusisto</name><affiliation><nlm:aff id="A107">Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kyvik, Kirsten Ohm" sort="Kyvik, Kirsten Ohm" uniqKey="Kyvik K" first="Kirsten Ohm" last="Kyvik">Kirsten Ohm Kyvik</name><affiliation><nlm:aff id="A108">Institute of Regional Health Services Research and Professor Odense Patient data Explorative Network (OPEN)</nlm:aff></affiliation></author><author><name sortKey="Laakso, Markku" sort="Laakso, Markku" uniqKey="Laakso M" first="Markku" last="Laakso">Markku Laakso</name><affiliation><nlm:aff id="A107">Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Lakka, Timo" sort="Lakka, Timo" uniqKey="Lakka T" first="Timo" last="Lakka">Timo Lakka</name><affiliation><nlm:aff id="A46">Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A109">Kuopio Research Institute of Exercise Medicine, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Lannfelt, Lars" sort="Lannfelt, Lars" uniqKey="Lannfelt L" first="Lars" last="Lannfelt">Lars Lannfelt</name><affiliation><nlm:aff id="A110">Department of Public Health and Caring Sciences, Uppsala University, Rudbecklaboratoriet, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lathrop, G Mark" sort="Lathrop, G Mark" uniqKey="Lathrop G" first="G Mark" last="Lathrop">G Mark Lathrop</name><affiliation><nlm:aff id="A89">Centre National de Génotypage, Commissariat à L’Energie Atomique, Institut de Génomique, Evry, France</nlm:aff></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><affiliation><nlm:aff id="A88">Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Leander, Karin" sort="Leander, Karin" uniqKey="Leander K" first="Karin" last="Leander">Karin Leander</name><affiliation><nlm:aff id="A68">Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name><affiliation><nlm:aff id="A111">Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation><nlm:aff id="A112">Department of Medical Sciences, University Hospital, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Jaana" sort="Lindstrom, Jaana" uniqKey="Lindstrom J" first="Jaana" last="Lindstrom">Jaana Lindstrom</name><affiliation><nlm:aff id="A113">Diabetes Prevention Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Lobbens, Stephane" sort="Lobbens, Stephane" uniqKey="Lobbens S" first="Stéphane" last="Lobbens">Stéphane Lobbens</name><affiliation><nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Lille Nord de France University, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J. F." last="Loos">Ruth J. F. Loos</name><affiliation><nlm:aff id="A7">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Luan, Jian N" sort="Luan, Jian N" uniqKey="Luan J" first="Jian N" last="Luan">Jian N Luan</name><affiliation><nlm:aff id="A7">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Lyssenko, Valeriya" sort="Lyssenko, Valeriya" uniqKey="Lyssenko V" first="Valeriya" last="Lyssenko">Valeriya Lyssenko</name><affiliation><nlm:aff id="A23">Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Lund University Diabetes Centre, Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><affiliation><nlm:aff id="A13">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A114">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Magnusson, Patrik K E" sort="Magnusson, Patrik K E" uniqKey="Magnusson P" first="Patrik K. E." last="Magnusson">Patrik K. E. Magnusson</name><affiliation><nlm:aff id="A19">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Marmot, Michael" sort="Marmot, Michael" uniqKey="Marmot M" first="Michael" last="Marmot">Michael Marmot</name><affiliation><nlm:aff id="A62">University College London, Department of Epidemiology & Public Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Meneton, Pierre" sort="Meneton, Pierre" uniqKey="Meneton P" first="Pierre" last="Meneton">Pierre Meneton</name><affiliation><nlm:aff id="A115">Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Mohlke, Karen L" sort="Mohlke, Karen L" uniqKey="Mohlke K" first="Karen L." last="Mohlke">Karen L. Mohlke</name><affiliation><nlm:aff id="A116">Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA</nlm:aff></affiliation></author><author><name sortKey="Mooser, Vincent" sort="Mooser, Vincent" uniqKey="Mooser V" first="Vincent" last="Mooser">Vincent Mooser</name><affiliation><nlm:aff id="A117">Division of Genetics, GlaxoSmithKline, Philadelphia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Morken, Mario A" sort="Morken, Mario A" uniqKey="Morken M" first="Mario A." last="Morken">Mario A. Morken</name><affiliation><nlm:aff id="A59">Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Miljkovic, Iva" sort="Miljkovic, Iva" uniqKey="Miljkovic I" first="Iva" last="Miljkovic">Iva Miljkovic</name><affiliation><nlm:aff id="A118">Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Narisu, Narisu" sort="Narisu, Narisu" uniqKey="Narisu N" first="Narisu" last="Narisu">Narisu Narisu</name><affiliation><nlm:aff id="A59">Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="O Onnell, Jeff" sort="O Onnell, Jeff" uniqKey="O Onnell J" first="Jeff" last="O Onnell">Jeff O Onnell</name><affiliation><nlm:aff id="A28">Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Ong, Ken K" sort="Ong, Ken K" uniqKey="Ong K" first="Ken K." last="Ong">Ken K. Ong</name><affiliation><nlm:aff id="A7">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name><affiliation><nlm:aff id="A119">Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J." last="Palmer">Lyle J. Palmer</name><affiliation><nlm:aff id="A16">Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research. Toronto, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation><nlm:aff id="A2">Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hixton, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A101">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A120">Department of Medical Genetics, University of Helsinki and Helsinki University Central Hospital, Finland</nlm:aff></affiliation></author><author><name sortKey="Pankow, James S" sort="Pankow, James S" uniqKey="Pankow J" first="James S." last="Pankow">James S. Pankow</name><affiliation><nlm:aff id="A121">Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Peden, John F" sort="Peden, John F" uniqKey="Peden J" first="John F." last="Peden">John F. Peden</name><affiliation><nlm:aff id="A86">Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L." last="Pedersen">Nancy L. Pedersen</name><affiliation><nlm:aff id="A19">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Pehlic, Marina" sort="Pehlic, Marina" uniqKey="Pehlic M" first="Marina" last="Pehlic">Marina Pehlic</name><affiliation><nlm:aff id="A122">Department of Biology, Faculty of Medicine, University of Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Peltonen, Leena" sort="Peltonen, Leena" uniqKey="Peltonen L" first="Leena" last="Peltonen">Leena Peltonen</name><affiliation><nlm:aff id="A22">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hixton, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A101">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Penninx, Brenda" sort="Penninx, Brenda" uniqKey="Penninx B" first="Brenda" last="Penninx">Brenda Penninx</name><affiliation><nlm:aff id="A123">Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A124">Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A125">Department Psychiatry, EMGO Institute for Health and Care Research and Institute for Neurosciences, VU University Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Pericic, Marijana" sort="Pericic, Marijana" uniqKey="Pericic M" first="Marijana" last="Pericic">Marijana Pericic</name><affiliation><nlm:aff id="A126">Institute for Anthropological Research, Zagreb, Croatia</nlm:aff></affiliation></author><author><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name><affiliation><nlm:aff id="A33">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Perusse, Louis" sort="Perusse, Louis" uniqKey="Perusse L" first="Louis" last="Perusse">Louis Perusse</name><affiliation><nlm:aff id="A127">Department of Preventive Medicine, Laval University, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Peyser, Patricia A" sort="Peyser, Patricia A" uniqKey="Peyser P" first="Patricia A" last="Peyser">Patricia A. Peyser</name><affiliation><nlm:aff id="A12">Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation><nlm:aff id="A105">Department of Public Health, Faculty of Medicine, University of Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><affiliation><nlm:aff id="A90">Center for Biomedicine, European Academy Bozen/Bolzano, Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Province, Michael A" sort="Province, Michael A" uniqKey="Province M" first="Michael A." last="Province">Michael A. Province</name><affiliation><nlm:aff id="A41">Department of Genetics Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="R Ikkonen, Katri" sort="R Ikkonen, Katri" uniqKey="R Ikkonen K" first="Katri" last="R Ikkönen">Katri R Ikkönen</name><affiliation><nlm:aff id="A25">Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Rauramaa, Rainer" sort="Rauramaa, Rainer" uniqKey="Rauramaa R" first="Rainer" last="Rauramaa">Rainer Rauramaa</name><affiliation><nlm:aff id="A109">Kuopio Research Institute of Exercise Medicine, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A128">Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Rehnberg, Emil" sort="Rehnberg, Emil" uniqKey="Rehnberg E" first="Emil" last="Rehnberg">Emil Rehnberg</name><affiliation><nlm:aff id="A19">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Rice, Ken" sort="Rice, Ken" uniqKey="Rice K" first="Ken" last="Rice">Ken Rice</name><affiliation><nlm:aff id="A129">Department of Biostatistics, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name><affiliation><nlm:aff id="A130">Medical Genetics Institute, Cedars-Sinai Medical Center</nlm:aff></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="A63">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A131">Centre for Global Health, University of Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Ruokonen, Aimo" sort="Ruokonen, Aimo" uniqKey="Ruokonen A" first="Aimo" last="Ruokonen">Aimo Ruokonen</name><affiliation><nlm:aff id="A132">Institute of Clinical Medicine, University of Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Saaristo, Timo" sort="Saaristo, Timo" uniqKey="Saaristo T" first="Timo" last="Saaristo">Timo Saaristo</name><affiliation><nlm:aff id="A133">Finnish Diabetes Association, Tampere, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A134">Pirkanmaa Hospital District, Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Sabater Lleal, Maria" sort="Sabater Lleal, Maria" uniqKey="Sabater Lleal M" first="Maria" last="Sabater-Lleal">Maria Sabater-Lleal</name><affiliation><nlm:aff id="A37">Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation><nlm:aff id="A33">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Savage, David B" sort="Savage, David B" uniqKey="Savage D" first="David B." last="Savage">David B. Savage</name><affiliation><nlm:aff id="A135">Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Saxena, Richa" sort="Saxena, Richa" uniqKey="Saxena R" first="Richa" last="Saxena">Richa Saxena</name><affiliation><nlm:aff id="A2">Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A136">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Schwarz, Peter" sort="Schwarz, Peter" uniqKey="Schwarz P" first="Peter" last="Schwarz">Peter Schwarz</name><affiliation><nlm:aff id="A137">Department of Medicine, Division Prevention and Care of Diabetes, University of Dresden, Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Seedorf, Udo" sort="Seedorf, Udo" uniqKey="Seedorf U" first="Udo" last="Seedorf">Udo Seedorf</name><affiliation><nlm:aff id="A138">Leibniz Institute for Arteriosclerosis Research, University of Munster, Germany</nlm:aff></affiliation></author><author><name sortKey="Sennblad, Bengt" sort="Sennblad, Bengt" uniqKey="Sennblad B" first="Bengt" last="Sennblad">Bengt Sennblad</name><affiliation><nlm:aff id="A37">Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Serrano Rios, Manuel" sort="Serrano Rios, Manuel" uniqKey="Serrano Rios M" first="Manuel" last="Serrano-Rios">Manuel Serrano-Rios</name><affiliation><nlm:aff id="A27">Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name><affiliation><nlm:aff id="A28">Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A139">Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Sijbrands, Eric J G" sort="Sijbrands, Eric J G" uniqKey="Sijbrands E" first="Eric J. G." last="Sijbrands">Eric J. G. Sijbrands</name><affiliation><nlm:aff id="A140">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S." last="Siscovick">David S. Siscovick</name><affiliation><nlm:aff id="A111">Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A141">Department of Medicine, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A142">Department of Epidemiology, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Smit, Johannes H" sort="Smit, Johannes H" uniqKey="Smit J" first="Johannes H." last="Smit">Johannes H. Smit</name><affiliation><nlm:aff id="A143">Department of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Small, Kerrin S" sort="Small, Kerrin S" uniqKey="Small K" first="Kerrin S." last="Small">Kerrin S. Small</name><affiliation><nlm:aff id="A31">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Smith, Nicholas L" sort="Smith, Nicholas L" uniqKey="Smith N" first="Nicholas L." last="Smith">Nicholas L. Smith</name><affiliation><nlm:aff id="A141">Department of Medicine, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A142">Department of Epidemiology, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A144">Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A145">Seattle Epidemiologic Research and Information Center, Veterans Affairs Office of Research and Development, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name><affiliation><nlm:aff id="A44">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A45">University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Stan Kova, Alena" sort="Stan Kova, Alena" uniqKey="Stan Kova A" first="Alena" last="Stan Ková">Alena Stan Ková</name><affiliation><nlm:aff id="A107">Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Stirrups, Kathleen" sort="Stirrups, Kathleen" uniqKey="Stirrups K" first="Kathleen" last="Stirrups">Kathleen Stirrups</name><affiliation><nlm:aff id="A22">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hixton, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation><nlm:aff id="A60">IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A146">Department of Medicine, University of Leipzig, Division of Endocrinology and Diabetes, Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Sun, Yan V" sort="Sun, Yan V" uniqKey="Sun Y" first="Yan V." last="Sun">Yan V. Sun</name><affiliation><nlm:aff id="A147">Department of Epidemiology, Emory University, Atlanta, Georgia, US</nlm:aff></affiliation></author><author><name sortKey="Swift, Amy J" sort="Swift, Amy J" uniqKey="Swift A" first="Amy J." last="Swift">Amy J. Swift</name><affiliation><nlm:aff id="A59">Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name><affiliation><nlm:aff id="A60">IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A146">Department of Medicine, University of Leipzig, Division of Endocrinology and Diabetes, Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Tuomilehto, Jaakko" sort="Tuomilehto, Jaakko" uniqKey="Tuomilehto J" first="Jaakko" last="Tuomilehto">Jaakko Tuomilehto</name><affiliation><nlm:aff id="A148">Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A149">South Ostrobothnia Central Hospital, Seinäjoki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A150">Hospital Universitario La Paz, Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A151">Centre for Vascular Prevention, Danube-University Krems, Krems, Austria</nlm:aff></affiliation></author><author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name><affiliation><nlm:aff id="A98">Department of Cardiology C5-P, Leiden University Medical Center, Leiden, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation><nlm:aff id="A15">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Netherlands Genomics Initiative and the Netherlands Consortium for Healthy Aging, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A140">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Uusitupa, Matti" sort="Uusitupa, Matti" uniqKey="Uusitupa M" first="Matti" last="Uusitupa">Matti Uusitupa</name><affiliation><nlm:aff id="A152">Institute of Public Health and Clinical Nutrition, University of Easten Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A153">Research Unit, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Vikstrom, Max" sort="Vikstrom, Max" uniqKey="Vikstrom M" first="Max" last="Vikström">Max Vikström</name><affiliation><nlm:aff id="A68">Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation><nlm:aff id="A29">MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Vohl, Marie Claude" sort="Vohl, Marie Claude" uniqKey="Vohl M" first="Marie-Claude" last="Vohl">Marie-Claude Vohl</name><affiliation><nlm:aff id="A154">Department of Food Science and Nutrition, Laval University, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Voight, Benjamin F" sort="Voight, Benjamin F" uniqKey="Voight B" first="Benjamin F." last="Voight">Benjamin F. Voight</name><affiliation><nlm:aff id="A2">Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:aff id="A155">Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Waeber, Gerard" sort="Waeber, Gerard" uniqKey="Waeber G" first="Gerard" last="Waeber">Gerard Waeber</name><affiliation><nlm:aff id="A155">Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Waterworth, Dawn M" sort="Waterworth, Dawn M" uniqKey="Waterworth D" first="Dawn M" last="Waterworth">Dawn M. Waterworth</name><affiliation><nlm:aff id="A117">Division of Genetics, GlaxoSmithKline, Philadelphia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name><affiliation><nlm:aff id="A86">Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Wheeler, Eleanor" sort="Wheeler, Eleanor" uniqKey="Wheeler E" first="Eleanor" last="Wheeler">Eleanor Wheeler</name><affiliation><nlm:aff id="A156">Metabolic Disease Group, Wellcome Trust Sanger Institute, Hinxton, UK</nlm:aff></affiliation></author><author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name><affiliation><nlm:aff id="A157">Institute for Molecular Medicine Finland, University of Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name><affiliation><nlm:aff id="A63">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Willems, Sara M" sort="Willems, Sara M" uniqKey="Willems S" first="Sara M." last="Willems">Sara M. Willems</name><affiliation><nlm:aff id="A15">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation><nlm:aff id="A18">Netherlands Twin Register, Department of Biological Psychology, VU University, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="A63">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Witteman, Jacqueline C M" sort="Witteman, Jacqueline C M" uniqKey="Witteman J" first="Jacqueline C. M." last="Witteman">Jacqueline C. M. Witteman</name><affiliation><nlm:aff id="A15">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Netherlands Genomics Initiative and the Netherlands Consortium for Healthy Aging, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name><affiliation><nlm:aff id="A29">MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Yaghootkar, Hanieh" sort="Yaghootkar, Hanieh" uniqKey="Yaghootkar H" first="Hanieh" last="Yaghootkar">Hanieh Yaghootkar</name><affiliation><nlm:aff id="A30">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff></affiliation></author><author><name sortKey="Zelenika, Diana" sort="Zelenika, Diana" uniqKey="Zelenika D" first="Diana" last="Zelenika">Diana Zelenika</name><affiliation><nlm:aff id="A89">Centre National de Génotypage, Commissariat à L’Energie Atomique, Institut de Génomique, Evry, France</nlm:aff></affiliation></author><author><name sortKey="Zemunik, Tatijana" sort="Zemunik, Tatijana" uniqKey="Zemunik T" first="Tatijana" last="Zemunik">Tatijana Zemunik</name><affiliation><nlm:aff id="A122">Department of Biology, Faculty of Medicine, University of Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Zgaga, Lina" sort="Zgaga, Lina" uniqKey="Zgaga L" first="Lina" last="Zgaga">Lina Zgaga</name><affiliation><nlm:aff id="A63">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A158">Department of medical statistics, epidemiology and medical informatics, University of Zagreb, Zagreb, Croatia</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A7">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I." last="Mccarthy">Mark I. Mccarthy</name><affiliation><nlm:aff id="A13">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A159">Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Barroso, Ines" sort="Barroso, Ines" uniqKey="Barroso I" first="Ines" last="Barroso">Ines Barroso</name><affiliation><nlm:aff id="A156">Metabolic Disease Group, Wellcome Trust Sanger Institute, Hinxton, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A160">University of Cambridge, Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Watanabe, Richard M" sort="Watanabe, Richard M" uniqKey="Watanabe R" first="Richard M." last="Watanabe">Richard M. Watanabe</name><affiliation><nlm:aff id="A56">Department of Physiology & Biophysics, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A161">Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Florez, Jose C" sort="Florez, Jose C" uniqKey="Florez J" first="Jose C." last="Florez">Jose C. Florez</name><affiliation><nlm:aff id="A2">Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A136">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A162">Diabetes Research Center, Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Dupuis, Josee" sort="Dupuis, Josee" uniqKey="Dupuis J" first="Josée" last="Dupuis">Josée Dupuis</name><affiliation><nlm:aff id="A1">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A77">National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Meigs, James B" sort="Meigs, James B" uniqKey="Meigs J" first="James B." last="Meigs">James B. Meigs</name><affiliation><nlm:aff id="A5">General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation><nlm:aff id="A7">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22581228</idno><idno type="pmc">3613127</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613127</idno><idno type="RBID">PMC:3613127</idno><idno type="doi">10.1038/ng.2274</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002134</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002134</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance</title><author><name sortKey="Manning, Alisa K" sort="Manning, Alisa K" uniqKey="Manning A" first="Alisa K." last="Manning">Alisa K. Manning</name><affiliation><nlm:aff id="A1">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Harvard Medical School, Boston, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Hivert, Marie France" sort="Hivert, Marie France" uniqKey="Hivert M" first="Marie-France" last="Hivert">Marie-France Hivert</name><affiliation><nlm:aff id="A5">General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Department of Medicine, Universite de Sherbrooke, Sherbrooke, Québec, Canada</nlm:aff></affiliation></author><author><name sortKey="Scott, Robert A" sort="Scott, Robert A" uniqKey="Scott R" first="Robert A." last="Scott">Robert A. Scott</name><affiliation><nlm:aff id="A7">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Grimsby, Jonna L" sort="Grimsby, Jonna L" uniqKey="Grimsby J" first="Jonna L." last="Grimsby">Jonna L. Grimsby</name><affiliation><nlm:aff id="A5">General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name><affiliation><nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Lille Nord de France University, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Chen, Han" sort="Chen, Han" uniqKey="Chen H" first="Han" last="Chen">Han Chen</name><affiliation><nlm:aff id="A1">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Rybin, Denis" sort="Rybin, Denis" uniqKey="Rybin D" first="Denis" last="Rybin">Denis Rybin</name><affiliation><nlm:aff id="A11">Boston University Data Coordinating Center, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Liu, Ching Ti" sort="Liu, Ching Ti" uniqKey="Liu C" first="Ching-Ti" last="Liu">Ching-Ti Liu</name><affiliation><nlm:aff id="A1">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Bielak, Lawrence F" sort="Bielak, Lawrence F" uniqKey="Bielak L" first="Lawrence F." last="Bielak">Lawrence F. Bielak</name><affiliation><nlm:aff id="A12">Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation><nlm:aff id="A13">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation><nlm:aff id="A15">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Barnes, Daniel" sort="Barnes, Daniel" uniqKey="Barnes D" first="Daniel" last="Barnes">Daniel Barnes</name><affiliation><nlm:aff id="A7">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Cadby, Gemma" sort="Cadby, Gemma" uniqKey="Cadby G" first="Gemma" last="Cadby">Gemma Cadby</name><affiliation><nlm:aff id="A16">Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research. Toronto, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation><nlm:aff id="A18">Netherlands Twin Register, Department of Biological Psychology, VU University, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation><nlm:aff id="A19">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Jackson, Anne U" sort="Jackson, Anne U" uniqKey="Jackson A" first="Anne U." last="Jackson">Anne U. Jackson</name><affiliation><nlm:aff id="A20">Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name><affiliation><nlm:aff id="A21">Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kanoni, Stavroula" sort="Kanoni, Stavroula" uniqKey="Kanoni S" first="Stavroula" last="Kanoni">Stavroula Kanoni</name><affiliation><nlm:aff id="A22">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hixton, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Ladenvall, Claes" sort="Ladenvall, Claes" uniqKey="Ladenvall C" first="Claes" last="Ladenvall">Claes Ladenvall</name><affiliation><nlm:aff id="A23">Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Lund University Diabetes Centre, Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lagou, Vasiliki" sort="Lagou, Vasiliki" uniqKey="Lagou V" first="Vasiliki" last="Lagou">Vasiliki Lagou</name><affiliation><nlm:aff id="A13">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><affiliation><nlm:aff id="A25">Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Lecoeur, Cecile" sort="Lecoeur, Cecile" uniqKey="Lecoeur C" first="Cecile" last="Lecoeur">Cecile Lecoeur</name><affiliation><nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Lille Nord de France University, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation><nlm:aff id="A26">Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA</nlm:aff></affiliation></author><author><name sortKey="Martinez Larrad, Maria Teresa" sort="Martinez Larrad, Maria Teresa" uniqKey="Martinez Larrad M" first="Maria Teresa" last="Martinez-Larrad">Maria Teresa Martinez-Larrad</name><affiliation><nlm:aff id="A27">Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Montasser, May E" sort="Montasser, May E" uniqKey="Montasser M" first="May E." last="Montasser">May E. Montasser</name><affiliation><nlm:aff id="A28">Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Navarro, Pau" sort="Navarro, Pau" uniqKey="Navarro P" first="Pau" last="Navarro">Pau Navarro</name><affiliation><nlm:aff id="A29">MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Perry, John R B" sort="Perry, John R B" uniqKey="Perry J" first="John R. B." last="Perry">John R. B. Perry</name><affiliation><nlm:aff id="A14">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Rasmussen Torvik, Laura J" sort="Rasmussen Torvik, Laura J" uniqKey="Rasmussen Torvik L" first="Laura J." last="Rasmussen-Torvik">Laura J. Rasmussen-Torvik</name><affiliation><nlm:aff id="A32">Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA</nlm:aff></affiliation></author><author><name sortKey="Salo, Perttu" sort="Salo, Perttu" uniqKey="Salo P" first="Perttu" last="Salo">Perttu Salo</name><affiliation><nlm:aff id="A33">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name><affiliation><nlm:aff id="A34">Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Shungin, Dmitry" sort="Shungin, Dmitry" uniqKey="Shungin D" first="Dmitry" last="Shungin">Dmitry Shungin</name><affiliation><nlm:aff id="A23">Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Lund University Diabetes Centre, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A35">Department of Public Health & Clinical Medicine, Genetic Epidemiology & Clinical Research Group, Umeå University Hospital, Umeå, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Department of Odontology, Umeå University, Sweden</nlm:aff></affiliation></author><author><name sortKey="Strawbridge, Rona J" sort="Strawbridge, Rona J" uniqKey="Strawbridge R" first="Rona J." last="Strawbridge">Rona J. Strawbridge</name><affiliation><nlm:aff id="A37">Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation><nlm:aff id="A38">Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A15">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Centre for medical systems biology, Netherlands Genomics Initiative, The Hague</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Netherlands Genomics Initiative and the Netherlands Consortium for Healthy Aging, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="An, Ping" sort="An, Ping" uniqKey="An P" first="Ping" last="An">Ping An</name><affiliation><nlm:aff id="A41">Department of Genetics Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="De Andrade, Mariza" sort="De Andrade, Mariza" uniqKey="De Andrade M" first="Mariza" last="De Andrade">Mariza De Andrade</name><affiliation><nlm:aff id="A42">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Andrews, Jeanette S" sort="Andrews, Jeanette S" uniqKey="Andrews J" first="Jeanette S." last="Andrews">Jeanette S. Andrews</name><affiliation><nlm:aff id="A43">Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA</nlm:aff></affiliation></author><author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name><affiliation><nlm:aff id="A44">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A45">University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Atalay, Mustafa" sort="Atalay, Mustafa" uniqKey="Atalay M" first="Mustafa" last="Atalay">Mustafa Atalay</name><affiliation><nlm:aff id="A46">Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Aulchenko, Yurii" sort="Aulchenko, Yurii" uniqKey="Aulchenko Y" first="Yurii" last="Aulchenko">Yurii Aulchenko</name><affiliation><nlm:aff id="A15">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><affiliation><nlm:aff id="A47">Inserm, CESP Centre for research in Epidemiology and Population Health, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A48">University Paris Sud 11, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name><affiliation><nlm:aff id="A49">Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Jacques S" sort="Beckmann, Jacques S" uniqKey="Beckmann J" first="Jacques S." last="Beckmann">Jacques S. Beckmann</name><affiliation><nlm:aff id="A50">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A51">Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Beilby, John P" sort="Beilby, John P" uniqKey="Beilby J" first="John P." last="Beilby">John P. Beilby</name><affiliation><nlm:aff id="A52">PathWest Laboratory Medicine of WA, J Block, QEII Medical Centre, Nedlands, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A53">School of Pathology and Laboratory Medicine, The University of Western Australia, Nedlands, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Busselton Population Medical Research Foundation, B Block, QEII Medical Centre, Nedlands, Australia</nlm:aff></affiliation></author><author><name sortKey="Bellis, Claire" sort="Bellis, Claire" uniqKey="Bellis C" first="Claire" last="Bellis">Claire Bellis</name><affiliation><nlm:aff id="A55">Texas Biomedical Research Institute, San Antonio, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Bergman, Richard N" sort="Bergman, Richard N" uniqKey="Bergman R" first="Richard N." last="Bergman">Richard N. Bergman</name><affiliation><nlm:aff id="A56">Department of Physiology & Biophysics, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Blangero, John" sort="Blangero, John" uniqKey="Blangero J" first="John" last="Blangero">John Blangero</name><affiliation><nlm:aff id="A55">Texas Biomedical Research Institute, San Antonio, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Boban, Mladen" sort="Boban, Mladen" uniqKey="Boban M" first="Mladen" last="Boban">Mladen Boban</name><affiliation><nlm:aff id="A57">Department of Pharmacology, Faculty of Medicine, University of Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Boehnke, Michael" sort="Boehnke, Michael" uniqKey="Boehnke M" first="Michael" last="Boehnke">Michael Boehnke</name><affiliation><nlm:aff id="A20">Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation><nlm:aff id="A58">Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Bonnycastle, Lori L" sort="Bonnycastle, Lori L" uniqKey="Bonnycastle L" first="Lori L." last="Bonnycastle">Lori L. Bonnycastle</name><affiliation><nlm:aff id="A59">Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:aff id="A18">Netherlands Twin Register, Department of Biological Psychology, VU University, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Borecki, Ingrid B" sort="Borecki, Ingrid B" uniqKey="Borecki I" first="Ingrid B." last="Borecki">Ingrid B. Borecki</name><affiliation><nlm:aff id="A41">Department of Genetics Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="Bottcher, Yvonne" sort="Bottcher, Yvonne" uniqKey="Bottcher Y" first="Yvonne" last="Böttcher">Yvonne Böttcher</name><affiliation><nlm:aff id="A60">IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Bouchard, Claude" sort="Bouchard, Claude" uniqKey="Bouchard C" first="Claude" last="Bouchard">Claude Bouchard</name><affiliation><nlm:aff id="A61">Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA</nlm:aff></affiliation></author><author><name sortKey="Brunner, Eric" sort="Brunner, Eric" uniqKey="Brunner E" first="Eric" last="Brunner">Eric Brunner</name><affiliation><nlm:aff id="A62">University College London, Department of Epidemiology & Public Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Budimir, Danijela" sort="Budimir, Danijela" uniqKey="Budimir D" first="Danijela" last="Budimir">Danijela Budimir</name><affiliation><nlm:aff id="A57">Department of Pharmacology, Faculty of Medicine, University of Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="A63">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Carlson, Olga" sort="Carlson, Olga" uniqKey="Carlson O" first="Olga" last="Carlson">Olga Carlson</name><affiliation><nlm:aff id="A64">Laboratory of Clinical Investigation, National Institute of Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Chines, Peter S" sort="Chines, Peter S" uniqKey="Chines P" first="Peter S." last="Chines">Peter S. Chines</name><affiliation><nlm:aff id="A59">Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name><affiliation><nlm:aff id="A65">Clinical Trial Service Unit, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Collins, Francis S" sort="Collins, Francis S" uniqKey="Collins F" first="Francis S." last="Collins">Francis S. Collins</name><affiliation><nlm:aff id="A66">Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Corbat N Anchuelo, Arturo" sort="Corbat N Anchuelo, Arturo" uniqKey="Corbat N Anchuelo A" first="Arturo" last="Corbat N-Anchuelo">Arturo Corbat N-Anchuelo</name><affiliation><nlm:aff id="A27">Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Couper, David" sort="Couper, David" uniqKey="Couper D" first="David" last="Couper">David Couper</name><affiliation><nlm:aff id="A67">Department of Biostatistics, University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina, USA</nlm:aff></affiliation></author><author><name sortKey="De Faire, Ulf" sort="De Faire, Ulf" uniqKey="De Faire U" first="Ulf" last="De Faire">Ulf De Faire</name><affiliation><nlm:aff id="A68">Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Dedoussis, George V" sort="Dedoussis, George V" uniqKey="Dedoussis G" first="George V" last="Dedoussis">George V. Dedoussis</name><affiliation><nlm:aff id="A69">Department of Nutrition - Dietetics, Harokopio University, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name><affiliation><nlm:aff id="A22">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hixton, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Dimitriou, Maria" sort="Dimitriou, Maria" uniqKey="Dimitriou M" first="Maria" last="Dimitriou">Maria Dimitriou</name><affiliation><nlm:aff id="A69">Department of Nutrition - Dietetics, Harokopio University, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Egan, Josephine M" sort="Egan, Josephine M" uniqKey="Egan J" first="Josephine M" last="Egan">Josephine M. Egan</name><affiliation><nlm:aff id="A64">Laboratory of Clinical Investigation, National Institute of Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation><nlm:aff id="A44">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation></author><author><name sortKey="Erdos, Michael R" sort="Erdos, Michael R" uniqKey="Erdos M" first="Michael R." last="Erdos">Michael R. Erdos</name><affiliation><nlm:aff id="A59">Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G." last="Eriksson">Johan G. Eriksson</name><affiliation><nlm:aff id="A70">Department of General Practice and Primary health Care, University of Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A71">Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Folkhalsan Research Centre, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Vaasa Central Hospital, Vaasa, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A74">National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Eury, Elodie" sort="Eury, Elodie" uniqKey="Eury E" first="Elodie" last="Eury">Elodie Eury</name><affiliation><nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Lille Nord de France University, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation><nlm:aff id="A75">Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name><affiliation><nlm:aff id="A76">Robertson Centre for Biostatistics, University of Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Forouhi, Nita G" sort="Forouhi, Nita G" uniqKey="Forouhi N" first="Nita G." last="Forouhi">Nita G. Forouhi</name><affiliation><nlm:aff id="A7">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S" last="Fox">Caroline S. Fox</name><affiliation><nlm:aff id="A77">National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A78">Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Franzosi, Maria Grazia" sort="Franzosi, Maria Grazia" uniqKey="Franzosi M" first="Maria Grazia" last="Franzosi">Maria Grazia Franzosi</name><affiliation><nlm:aff id="A79">Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Franks, Paul W" sort="Franks, Paul W" uniqKey="Franks P" first="Paul W" last="Franks">Paul W. Franks</name><affiliation><nlm:aff id="A23">Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Lund University Diabetes Centre, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A35">Department of Public Health & Clinical Medicine, Genetic Epidemiology & Clinical Research Group, Umeå University Hospital, Umeå, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A80">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A81">Institut National de la Recherche Agronomique, Université Paris, Bobigny Cedex, France</nlm:aff></affiliation></author><author><name sortKey="Frayling, Timothy M" sort="Frayling, Timothy M" uniqKey="Frayling T" first="Timothy M" last="Frayling">Timothy M. Frayling</name><affiliation><nlm:aff id="A30">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Lille Nord de France University, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A82">Genomic Medicine, Hammersmith Hospital, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name><affiliation><nlm:aff id="A83">Institut National de la Santé et de la Recherche Médicale, Université Paris, Bobigny Cedex, France</nlm:aff></affiliation></author><author><name sortKey="De Geus, Eco" sort="De Geus, Eco" uniqKey="De Geus E" first="Eco" last="De Geus">Eco De Geus</name><affiliation><nlm:aff id="A18">Netherlands Twin Register, Department of Biological Psychology, VU University, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Gigante, Bruna" sort="Gigante, Bruna" uniqKey="Gigante B" first="Bruna" last="Gigante">Bruna Gigante</name><affiliation><nlm:aff id="A68">Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Glazer, Nicole L" sort="Glazer, Nicole L" uniqKey="Glazer N" first="Nicole L." last="Glazer">Nicole L. Glazer</name><affiliation><nlm:aff id="A84">Department of Medicine, Section of Preventive Medicine and Epidemiology, BU School of Medicine, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A85">Department of Epidemiology, BU School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name><affiliation><nlm:aff id="A86">Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Groop, Leif" sort="Groop, Leif" uniqKey="Groop L" first="Leif" last="Groop">Leif Groop</name><affiliation><nlm:aff id="A23">Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Lund University Diabetes Centre, Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="A44">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A45">University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Hallmans, Goran" sort="Hallmans, Goran" uniqKey="Hallmans G" first="Göran" last="Hallmans">Göran Hallmans</name><affiliation><nlm:aff id="A87">Department of Public Health & Clinical Medicine, Nutrition Research, Umeå University, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name><affiliation><nlm:aff id="A37">Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hansson, Ola" sort="Hansson, Ola" uniqKey="Hansson O" first="Ola" last="Hansson">Ola Hansson</name><affiliation><nlm:aff id="A23">Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Lund University Diabetes Centre, Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="A88">Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="A29">MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Heath, Simon" sort="Heath, Simon" uniqKey="Heath S" first="Simon" last="Heath">Simon Heath</name><affiliation><nlm:aff id="A89">Centre National de Génotypage, Commissariat à L’Energie Atomique, Institut de Génomique, Evry, France</nlm:aff></affiliation></author><author><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name><affiliation><nlm:aff id="A83">Institut National de la Santé et de la Recherche Médicale, Université Paris, Bobigny Cedex, France</nlm:aff></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A." last="Hicks">Andrew A. Hicks</name><affiliation><nlm:aff id="A90">Center for Biomedicine, European Academy Bozen/Bolzano, Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Hingorani, Aroon" sort="Hingorani, Aroon" uniqKey="Hingorani A" first="Aroon" last="Hingorani">Aroon Hingorani</name><affiliation><nlm:aff id="A91">Genetic epidemiology group, University College London, Department of Epidemiology & Public Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A15">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Netherlands Genomics Initiative and the Netherlands Consortium for Healthy Aging, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hui, Jennie" sort="Hui, Jennie" uniqKey="Hui J" first="Jennie" last="Hui">Jennie Hui</name><affiliation><nlm:aff id="A52">PathWest Laboratory Medicine of WA, J Block, QEII Medical Centre, Nedlands, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A53">School of Pathology and Laboratory Medicine, The University of Western Australia, Nedlands, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Busselton Population Medical Research Foundation, B Block, QEII Medical Centre, Nedlands, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A92">School of Population Health, The University of Western Australia, Nedlands, Australia</nlm:aff></affiliation></author><author><name sortKey="Hung, Joseph" sort="Hung, Joseph" uniqKey="Hung J" first="Joseph" last="Hung">Joseph Hung</name><affiliation><nlm:aff id="A54">Busselton Population Medical Research Foundation, B Block, QEII Medical Centre, Nedlands, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A93">Sir Charles Gairdner Hospital Unit, School of Medicine & Pharmacology, University of Western Australia, Australia</nlm:aff></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo Riitta" last="Jarvelin">Marjo Riitta Jarvelin</name><affiliation><nlm:aff id="A94">Department of Epidemiology and Biostatistics, School of Public Health, MRC-HPA Centre for Environment and Health, Faculty of Medicine, Imperial College London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A95">Institute of Health Sciences, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A96">Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A97">National Institute of Health and Welfare, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Jhun, Min A" sort="Jhun, Min A" uniqKey="Jhun M" first="Min A." last="Jhun">Min A. Jhun</name><affiliation><nlm:aff id="A12">Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Johnson, Paul C D" sort="Johnson, Paul C D" uniqKey="Johnson P" first="Paul C. D." last="Johnson">Paul C. D. Johnson</name><affiliation><nlm:aff id="A76">Robertson Centre for Biostatistics, University of Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J Wouter" last="Jukema">J Wouter Jukema</name><affiliation><nlm:aff id="A98">Department of Cardiology C5-P, Leiden University Medical Center, Leiden, the Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A99">Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Jula, Antti" sort="Jula, Antti" uniqKey="Jula A" first="Antti" last="Jula">Antti Jula</name><affiliation><nlm:aff id="A33">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kao, W H" sort="Kao, W H" uniqKey="Kao W" first="W. H." last="Kao">W. H. Kao</name><affiliation><nlm:aff id="A100">Division of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation><nlm:aff id="A74">National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A101">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A102">Hjelt Institute, Dept of Public Health, University of Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kardia, Sharon L R" sort="Kardia, Sharon L R" uniqKey="Kardia S" first="Sharon L. R." last="Kardia">Sharon L. R. Kardia</name><affiliation><nlm:aff id="A12">Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Keinanen Kiukaanniemi, Sirkka" sort="Keinanen Kiukaanniemi, Sirkka" uniqKey="Keinanen Kiukaanniemi S" first="Sirkka" last="Keinanen-Kiukaanniemi">Sirkka Keinanen-Kiukaanniemi</name><affiliation><nlm:aff id="A103">Faculty of Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A104">Unit of General Practice, Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name><affiliation><nlm:aff id="A62">University College London, Department of Epidemiology & Public Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name><affiliation><nlm:aff id="A105">Department of Public Health, Faculty of Medicine, University of Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Kovacs, Peter" sort="Kovacs, Peter" uniqKey="Kovacs P" first="Peter" last="Kovacs">Peter Kovacs</name><affiliation><nlm:aff id="A106">Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name><affiliation><nlm:aff id="A91">Genetic epidemiology group, University College London, Department of Epidemiology & Public Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kuusisto, Johanna" sort="Kuusisto, Johanna" uniqKey="Kuusisto J" first="Johanna" last="Kuusisto">Johanna Kuusisto</name><affiliation><nlm:aff id="A107">Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kyvik, Kirsten Ohm" sort="Kyvik, Kirsten Ohm" uniqKey="Kyvik K" first="Kirsten Ohm" last="Kyvik">Kirsten Ohm Kyvik</name><affiliation><nlm:aff id="A108">Institute of Regional Health Services Research and Professor Odense Patient data Explorative Network (OPEN)</nlm:aff></affiliation></author><author><name sortKey="Laakso, Markku" sort="Laakso, Markku" uniqKey="Laakso M" first="Markku" last="Laakso">Markku Laakso</name><affiliation><nlm:aff id="A107">Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Lakka, Timo" sort="Lakka, Timo" uniqKey="Lakka T" first="Timo" last="Lakka">Timo Lakka</name><affiliation><nlm:aff id="A46">Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A109">Kuopio Research Institute of Exercise Medicine, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Lannfelt, Lars" sort="Lannfelt, Lars" uniqKey="Lannfelt L" first="Lars" last="Lannfelt">Lars Lannfelt</name><affiliation><nlm:aff id="A110">Department of Public Health and Caring Sciences, Uppsala University, Rudbecklaboratoriet, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lathrop, G Mark" sort="Lathrop, G Mark" uniqKey="Lathrop G" first="G Mark" last="Lathrop">G Mark Lathrop</name><affiliation><nlm:aff id="A89">Centre National de Génotypage, Commissariat à L’Energie Atomique, Institut de Génomique, Evry, France</nlm:aff></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><affiliation><nlm:aff id="A88">Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Leander, Karin" sort="Leander, Karin" uniqKey="Leander K" first="Karin" last="Leander">Karin Leander</name><affiliation><nlm:aff id="A68">Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name><affiliation><nlm:aff id="A111">Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation><nlm:aff id="A112">Department of Medical Sciences, University Hospital, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Jaana" sort="Lindstrom, Jaana" uniqKey="Lindstrom J" first="Jaana" last="Lindstrom">Jaana Lindstrom</name><affiliation><nlm:aff id="A113">Diabetes Prevention Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Lobbens, Stephane" sort="Lobbens, Stephane" uniqKey="Lobbens S" first="Stéphane" last="Lobbens">Stéphane Lobbens</name><affiliation><nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Lille Nord de France University, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J. F." last="Loos">Ruth J. F. Loos</name><affiliation><nlm:aff id="A7">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Luan, Jian N" sort="Luan, Jian N" uniqKey="Luan J" first="Jian N" last="Luan">Jian N Luan</name><affiliation><nlm:aff id="A7">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Lyssenko, Valeriya" sort="Lyssenko, Valeriya" uniqKey="Lyssenko V" first="Valeriya" last="Lyssenko">Valeriya Lyssenko</name><affiliation><nlm:aff id="A23">Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Lund University Diabetes Centre, Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><affiliation><nlm:aff id="A13">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A114">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Magnusson, Patrik K E" sort="Magnusson, Patrik K E" uniqKey="Magnusson P" first="Patrik K. E." last="Magnusson">Patrik K. E. Magnusson</name><affiliation><nlm:aff id="A19">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Marmot, Michael" sort="Marmot, Michael" uniqKey="Marmot M" first="Michael" last="Marmot">Michael Marmot</name><affiliation><nlm:aff id="A62">University College London, Department of Epidemiology & Public Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Meneton, Pierre" sort="Meneton, Pierre" uniqKey="Meneton P" first="Pierre" last="Meneton">Pierre Meneton</name><affiliation><nlm:aff id="A115">Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Mohlke, Karen L" sort="Mohlke, Karen L" uniqKey="Mohlke K" first="Karen L." last="Mohlke">Karen L. Mohlke</name><affiliation><nlm:aff id="A116">Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA</nlm:aff></affiliation></author><author><name sortKey="Mooser, Vincent" sort="Mooser, Vincent" uniqKey="Mooser V" first="Vincent" last="Mooser">Vincent Mooser</name><affiliation><nlm:aff id="A117">Division of Genetics, GlaxoSmithKline, Philadelphia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Morken, Mario A" sort="Morken, Mario A" uniqKey="Morken M" first="Mario A." last="Morken">Mario A. Morken</name><affiliation><nlm:aff id="A59">Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Miljkovic, Iva" sort="Miljkovic, Iva" uniqKey="Miljkovic I" first="Iva" last="Miljkovic">Iva Miljkovic</name><affiliation><nlm:aff id="A118">Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Narisu, Narisu" sort="Narisu, Narisu" uniqKey="Narisu N" first="Narisu" last="Narisu">Narisu Narisu</name><affiliation><nlm:aff id="A59">Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="O Onnell, Jeff" sort="O Onnell, Jeff" uniqKey="O Onnell J" first="Jeff" last="O Onnell">Jeff O Onnell</name><affiliation><nlm:aff id="A28">Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Ong, Ken K" sort="Ong, Ken K" uniqKey="Ong K" first="Ken K." last="Ong">Ken K. Ong</name><affiliation><nlm:aff id="A7">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name><affiliation><nlm:aff id="A119">Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J." last="Palmer">Lyle J. Palmer</name><affiliation><nlm:aff id="A16">Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research. Toronto, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation><nlm:aff id="A2">Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hixton, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A101">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A120">Department of Medical Genetics, University of Helsinki and Helsinki University Central Hospital, Finland</nlm:aff></affiliation></author><author><name sortKey="Pankow, James S" sort="Pankow, James S" uniqKey="Pankow J" first="James S." last="Pankow">James S. Pankow</name><affiliation><nlm:aff id="A121">Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Peden, John F" sort="Peden, John F" uniqKey="Peden J" first="John F." last="Peden">John F. Peden</name><affiliation><nlm:aff id="A86">Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L." last="Pedersen">Nancy L. Pedersen</name><affiliation><nlm:aff id="A19">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Pehlic, Marina" sort="Pehlic, Marina" uniqKey="Pehlic M" first="Marina" last="Pehlic">Marina Pehlic</name><affiliation><nlm:aff id="A122">Department of Biology, Faculty of Medicine, University of Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Peltonen, Leena" sort="Peltonen, Leena" uniqKey="Peltonen L" first="Leena" last="Peltonen">Leena Peltonen</name><affiliation><nlm:aff id="A22">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hixton, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A101">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Penninx, Brenda" sort="Penninx, Brenda" uniqKey="Penninx B" first="Brenda" last="Penninx">Brenda Penninx</name><affiliation><nlm:aff id="A123">Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A124">Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A125">Department Psychiatry, EMGO Institute for Health and Care Research and Institute for Neurosciences, VU University Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Pericic, Marijana" sort="Pericic, Marijana" uniqKey="Pericic M" first="Marijana" last="Pericic">Marijana Pericic</name><affiliation><nlm:aff id="A126">Institute for Anthropological Research, Zagreb, Croatia</nlm:aff></affiliation></author><author><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name><affiliation><nlm:aff id="A33">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Perusse, Louis" sort="Perusse, Louis" uniqKey="Perusse L" first="Louis" last="Perusse">Louis Perusse</name><affiliation><nlm:aff id="A127">Department of Preventive Medicine, Laval University, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Peyser, Patricia A" sort="Peyser, Patricia A" uniqKey="Peyser P" first="Patricia A" last="Peyser">Patricia A. Peyser</name><affiliation><nlm:aff id="A12">Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation><nlm:aff id="A105">Department of Public Health, Faculty of Medicine, University of Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><affiliation><nlm:aff id="A90">Center for Biomedicine, European Academy Bozen/Bolzano, Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Province, Michael A" sort="Province, Michael A" uniqKey="Province M" first="Michael A." last="Province">Michael A. Province</name><affiliation><nlm:aff id="A41">Department of Genetics Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="R Ikkonen, Katri" sort="R Ikkonen, Katri" uniqKey="R Ikkonen K" first="Katri" last="R Ikkönen">Katri R Ikkönen</name><affiliation><nlm:aff id="A25">Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Rauramaa, Rainer" sort="Rauramaa, Rainer" uniqKey="Rauramaa R" first="Rainer" last="Rauramaa">Rainer Rauramaa</name><affiliation><nlm:aff id="A109">Kuopio Research Institute of Exercise Medicine, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A128">Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Rehnberg, Emil" sort="Rehnberg, Emil" uniqKey="Rehnberg E" first="Emil" last="Rehnberg">Emil Rehnberg</name><affiliation><nlm:aff id="A19">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Rice, Ken" sort="Rice, Ken" uniqKey="Rice K" first="Ken" last="Rice">Ken Rice</name><affiliation><nlm:aff id="A129">Department of Biostatistics, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name><affiliation><nlm:aff id="A130">Medical Genetics Institute, Cedars-Sinai Medical Center</nlm:aff></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="A63">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A131">Centre for Global Health, University of Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Ruokonen, Aimo" sort="Ruokonen, Aimo" uniqKey="Ruokonen A" first="Aimo" last="Ruokonen">Aimo Ruokonen</name><affiliation><nlm:aff id="A132">Institute of Clinical Medicine, University of Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Saaristo, Timo" sort="Saaristo, Timo" uniqKey="Saaristo T" first="Timo" last="Saaristo">Timo Saaristo</name><affiliation><nlm:aff id="A133">Finnish Diabetes Association, Tampere, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A134">Pirkanmaa Hospital District, Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Sabater Lleal, Maria" sort="Sabater Lleal, Maria" uniqKey="Sabater Lleal M" first="Maria" last="Sabater-Lleal">Maria Sabater-Lleal</name><affiliation><nlm:aff id="A37">Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation><nlm:aff id="A33">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Savage, David B" sort="Savage, David B" uniqKey="Savage D" first="David B." last="Savage">David B. Savage</name><affiliation><nlm:aff id="A135">Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Saxena, Richa" sort="Saxena, Richa" uniqKey="Saxena R" first="Richa" last="Saxena">Richa Saxena</name><affiliation><nlm:aff id="A2">Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A136">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Schwarz, Peter" sort="Schwarz, Peter" uniqKey="Schwarz P" first="Peter" last="Schwarz">Peter Schwarz</name><affiliation><nlm:aff id="A137">Department of Medicine, Division Prevention and Care of Diabetes, University of Dresden, Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Seedorf, Udo" sort="Seedorf, Udo" uniqKey="Seedorf U" first="Udo" last="Seedorf">Udo Seedorf</name><affiliation><nlm:aff id="A138">Leibniz Institute for Arteriosclerosis Research, University of Munster, Germany</nlm:aff></affiliation></author><author><name sortKey="Sennblad, Bengt" sort="Sennblad, Bengt" uniqKey="Sennblad B" first="Bengt" last="Sennblad">Bengt Sennblad</name><affiliation><nlm:aff id="A37">Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Serrano Rios, Manuel" sort="Serrano Rios, Manuel" uniqKey="Serrano Rios M" first="Manuel" last="Serrano-Rios">Manuel Serrano-Rios</name><affiliation><nlm:aff id="A27">Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name><affiliation><nlm:aff id="A28">Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A139">Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Sijbrands, Eric J G" sort="Sijbrands, Eric J G" uniqKey="Sijbrands E" first="Eric J. G." last="Sijbrands">Eric J. G. Sijbrands</name><affiliation><nlm:aff id="A140">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S." last="Siscovick">David S. Siscovick</name><affiliation><nlm:aff id="A111">Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A141">Department of Medicine, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A142">Department of Epidemiology, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Smit, Johannes H" sort="Smit, Johannes H" uniqKey="Smit J" first="Johannes H." last="Smit">Johannes H. Smit</name><affiliation><nlm:aff id="A143">Department of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Small, Kerrin S" sort="Small, Kerrin S" uniqKey="Small K" first="Kerrin S." last="Small">Kerrin S. Small</name><affiliation><nlm:aff id="A31">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Smith, Nicholas L" sort="Smith, Nicholas L" uniqKey="Smith N" first="Nicholas L." last="Smith">Nicholas L. Smith</name><affiliation><nlm:aff id="A141">Department of Medicine, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A142">Department of Epidemiology, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A144">Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A145">Seattle Epidemiologic Research and Information Center, Veterans Affairs Office of Research and Development, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name><affiliation><nlm:aff id="A44">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A45">University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Stan Kova, Alena" sort="Stan Kova, Alena" uniqKey="Stan Kova A" first="Alena" last="Stan Ková">Alena Stan Ková</name><affiliation><nlm:aff id="A107">Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Stirrups, Kathleen" sort="Stirrups, Kathleen" uniqKey="Stirrups K" first="Kathleen" last="Stirrups">Kathleen Stirrups</name><affiliation><nlm:aff id="A22">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hixton, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation><nlm:aff id="A60">IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A146">Department of Medicine, University of Leipzig, Division of Endocrinology and Diabetes, Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Sun, Yan V" sort="Sun, Yan V" uniqKey="Sun Y" first="Yan V." last="Sun">Yan V. Sun</name><affiliation><nlm:aff id="A147">Department of Epidemiology, Emory University, Atlanta, Georgia, US</nlm:aff></affiliation></author><author><name sortKey="Swift, Amy J" sort="Swift, Amy J" uniqKey="Swift A" first="Amy J." last="Swift">Amy J. Swift</name><affiliation><nlm:aff id="A59">Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name><affiliation><nlm:aff id="A60">IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A146">Department of Medicine, University of Leipzig, Division of Endocrinology and Diabetes, Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Tuomilehto, Jaakko" sort="Tuomilehto, Jaakko" uniqKey="Tuomilehto J" first="Jaakko" last="Tuomilehto">Jaakko Tuomilehto</name><affiliation><nlm:aff id="A148">Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A149">South Ostrobothnia Central Hospital, Seinäjoki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A150">Hospital Universitario La Paz, Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A151">Centre for Vascular Prevention, Danube-University Krems, Krems, Austria</nlm:aff></affiliation></author><author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name><affiliation><nlm:aff id="A98">Department of Cardiology C5-P, Leiden University Medical Center, Leiden, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation><nlm:aff id="A15">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Netherlands Genomics Initiative and the Netherlands Consortium for Healthy Aging, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A140">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Uusitupa, Matti" sort="Uusitupa, Matti" uniqKey="Uusitupa M" first="Matti" last="Uusitupa">Matti Uusitupa</name><affiliation><nlm:aff id="A152">Institute of Public Health and Clinical Nutrition, University of Easten Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A153">Research Unit, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Vikstrom, Max" sort="Vikstrom, Max" uniqKey="Vikstrom M" first="Max" last="Vikström">Max Vikström</name><affiliation><nlm:aff id="A68">Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation><nlm:aff id="A29">MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Vohl, Marie Claude" sort="Vohl, Marie Claude" uniqKey="Vohl M" first="Marie-Claude" last="Vohl">Marie-Claude Vohl</name><affiliation><nlm:aff id="A154">Department of Food Science and Nutrition, Laval University, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Voight, Benjamin F" sort="Voight, Benjamin F" uniqKey="Voight B" first="Benjamin F." last="Voight">Benjamin F. Voight</name><affiliation><nlm:aff id="A2">Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:aff id="A155">Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Waeber, Gerard" sort="Waeber, Gerard" uniqKey="Waeber G" first="Gerard" last="Waeber">Gerard Waeber</name><affiliation><nlm:aff id="A155">Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Waterworth, Dawn M" sort="Waterworth, Dawn M" uniqKey="Waterworth D" first="Dawn M" last="Waterworth">Dawn M. Waterworth</name><affiliation><nlm:aff id="A117">Division of Genetics, GlaxoSmithKline, Philadelphia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name><affiliation><nlm:aff id="A86">Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Wheeler, Eleanor" sort="Wheeler, Eleanor" uniqKey="Wheeler E" first="Eleanor" last="Wheeler">Eleanor Wheeler</name><affiliation><nlm:aff id="A156">Metabolic Disease Group, Wellcome Trust Sanger Institute, Hinxton, UK</nlm:aff></affiliation></author><author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name><affiliation><nlm:aff id="A157">Institute for Molecular Medicine Finland, University of Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name><affiliation><nlm:aff id="A63">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Willems, Sara M" sort="Willems, Sara M" uniqKey="Willems S" first="Sara M." last="Willems">Sara M. Willems</name><affiliation><nlm:aff id="A15">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation><nlm:aff id="A18">Netherlands Twin Register, Department of Biological Psychology, VU University, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="A63">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Witteman, Jacqueline C M" sort="Witteman, Jacqueline C M" uniqKey="Witteman J" first="Jacqueline C. M." last="Witteman">Jacqueline C. M. Witteman</name><affiliation><nlm:aff id="A15">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Netherlands Genomics Initiative and the Netherlands Consortium for Healthy Aging, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name><affiliation><nlm:aff id="A29">MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Yaghootkar, Hanieh" sort="Yaghootkar, Hanieh" uniqKey="Yaghootkar H" first="Hanieh" last="Yaghootkar">Hanieh Yaghootkar</name><affiliation><nlm:aff id="A30">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff></affiliation></author><author><name sortKey="Zelenika, Diana" sort="Zelenika, Diana" uniqKey="Zelenika D" first="Diana" last="Zelenika">Diana Zelenika</name><affiliation><nlm:aff id="A89">Centre National de Génotypage, Commissariat à L’Energie Atomique, Institut de Génomique, Evry, France</nlm:aff></affiliation></author><author><name sortKey="Zemunik, Tatijana" sort="Zemunik, Tatijana" uniqKey="Zemunik T" first="Tatijana" last="Zemunik">Tatijana Zemunik</name><affiliation><nlm:aff id="A122">Department of Biology, Faculty of Medicine, University of Split, Croatia</nlm:aff></affiliation></author><author><name sortKey="Zgaga, Lina" sort="Zgaga, Lina" uniqKey="Zgaga L" first="Lina" last="Zgaga">Lina Zgaga</name><affiliation><nlm:aff id="A63">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A158">Department of medical statistics, epidemiology and medical informatics, University of Zagreb, Zagreb, Croatia</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A7">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I." last="Mccarthy">Mark I. Mccarthy</name><affiliation><nlm:aff id="A13">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A159">Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Barroso, Ines" sort="Barroso, Ines" uniqKey="Barroso I" first="Ines" last="Barroso">Ines Barroso</name><affiliation><nlm:aff id="A156">Metabolic Disease Group, Wellcome Trust Sanger Institute, Hinxton, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A160">University of Cambridge, Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Watanabe, Richard M" sort="Watanabe, Richard M" uniqKey="Watanabe R" first="Richard M." last="Watanabe">Richard M. Watanabe</name><affiliation><nlm:aff id="A56">Department of Physiology & Biophysics, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A161">Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Florez, Jose C" sort="Florez, Jose C" uniqKey="Florez J" first="Jose C." last="Florez">Jose C. Florez</name><affiliation><nlm:aff id="A2">Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A136">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A162">Diabetes Research Center, Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Dupuis, Josee" sort="Dupuis, Josee" uniqKey="Dupuis J" first="Josée" last="Dupuis">Josée Dupuis</name><affiliation><nlm:aff id="A1">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A77">National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Meigs, James B" sort="Meigs, James B" uniqKey="Meigs J" first="James B." last="Meigs">James B. Meigs</name><affiliation><nlm:aff id="A5">General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation><nlm:aff id="A7">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and beta-cell dysfunction, but contributed little to our understanding of the genetic basis of insulin resistance. We hypothesized that genes implicated in insulin resistance pathways may be uncovered by accounting for differences in body mass index (BMI) and potential interaction between BMI and genetic variants. We applied a novel joint meta-analytical approach to test associations with fasting insulin (FI) and glucose (FG) on a genome-wide scale. We present six previously unknown FI loci at <italic>P</italic><5×10<sup>−8</sup> in combined discovery and follow-up analyses of 52 studies comprising up to 96,496non-diabetic individuals. Risk variants were associated with higher triglyceride and lower HDL cholesterol levels, suggestive of a role for these FI loci in insulin resistance pathways. The localization of these additional loci will aid further characterization of the role of insulin resistance in T2D pathophysiology.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id><journal-id journal-id-type="pubmed-jr-id">2419</journal-id><journal-id journal-id-type="nlm-ta">Nat Genet</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Genet.</journal-id><journal-title-group><journal-title>Nature genetics</journal-title></journal-title-group><issn pub-type="ppub">1061-4036</issn><issn pub-type="epub">1546-1718</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22581228</article-id><article-id pub-id-type="pmc">3613127</article-id><article-id pub-id-type="doi">10.1038/ng.2274</article-id><article-id pub-id-type="manuscript">NIHMS430753</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Manning</surname><given-names>Alisa K.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref 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rid="A157">157</xref></contrib><contrib contrib-type="author"><name><surname>Wild</surname><given-names>Sarah H.</given-names></name><xref ref-type="aff" rid="A63">63</xref></contrib><contrib contrib-type="author"><name><surname>Willems</surname><given-names>Sara M.</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Willemsen</surname><given-names>Gonneke</given-names></name><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Wilson</surname><given-names>James F.</given-names></name><xref ref-type="aff" rid="A63">63</xref></contrib><contrib contrib-type="author"><name><surname>Witteman</surname><given-names>Jacqueline C.M.</given-names></name><xref ref-type="aff" rid="A15">15</xref><xref ref-type="aff" rid="A40">40</xref></contrib><contrib contrib-type="author"><name><surname>Wright</surname><given-names>Alan F.</given-names></name><xref ref-type="aff" 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contrib-type="author"><name><surname>Wareham</surname><given-names>Nicholas J.</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>McCarthy</surname><given-names>Mark I.</given-names></name><xref ref-type="aff" rid="A13">13</xref><xref ref-type="aff" rid="A14">14</xref><xref ref-type="aff" rid="A159">160</xref></contrib><contrib contrib-type="author"><name><surname>Barroso</surname><given-names>Ines</given-names></name><xref ref-type="aff" rid="A156">156</xref><xref ref-type="aff" rid="A160">161</xref></contrib><contrib contrib-type="author"><name><surname>Watanabe</surname><given-names>Richard M.</given-names></name><xref ref-type="aff" rid="A56">56</xref><xref ref-type="aff" rid="A161">162</xref></contrib><contrib contrib-type="author"><name><surname>Florez</surname><given-names>Jose C.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A136">136</xref><xref ref-type="aff" rid="A162">163</xref></contrib><contrib contrib-type="author"><name><surname>Dupuis</surname><given-names>Josée</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A77">77</xref></contrib><contrib contrib-type="author"><name><surname>Meigs</surname><given-names>James B.</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A8">8</xref><xref rid="FN1" ref-type="author-notes">†</xref></contrib><contrib contrib-type="author"><name><surname>Langenberg</surname><given-names>Claudia</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref rid="FN1" ref-type="author-notes">†</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA</aff><aff id="A2"><label>2</label>Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA</aff><aff id="A3"><label>3</label>Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA</aff><aff id="A4"><label>4</label>Harvard Medical School, Boston, Massachusetts</aff><aff id="A5"><label>5</label>General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA</aff><aff id="A6"><label>6</label>Department of Medicine, Universite de Sherbrooke, Sherbrooke, Québec, Canada</aff><aff id="A7"><label>7</label>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</aff><aff id="A8"><label>8</label>Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA</aff><aff id="A9"><label>9</label>Institut Pasteur de Lille, Lille, France</aff><aff id="A10"><label>10</label>Lille Nord de France University, Lille, France</aff><aff id="A11"><label>11</label>Boston University Data Coordinating Center, Boston, Massachusetts, USA</aff><aff id="A12"><label>12</label>Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA</aff><aff id="A13"><label>13</label>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK</aff><aff id="A14"><label>14</label>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</aff><aff id="A15"><label>15</label>Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands</aff><aff id="A16"><label>16</label>Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research. Toronto, Canada</aff><aff id="A17"><label>17</label>Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Toronto, Canada</aff><aff id="A18"><label>18</label>Netherlands Twin Register, Department of Biological Psychology, VU University, Amsterdam, The Netherlands</aff><aff id="A19"><label>19</label>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A20"><label>20</label>Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA</aff><aff id="A21"><label>21</label>Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</aff><aff id="A22"><label>22</label>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hixton, Cambridge, UK</aff><aff id="A23"><label>23</label>Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmö, Sweden</aff><aff id="A24"><label>24</label>Lund University Diabetes Centre, Malmö, Sweden</aff><aff id="A25"><label>25</label>Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland</aff><aff id="A26"><label>26</label>Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA</aff><aff id="A27"><label>27</label>Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain</aff><aff id="A28"><label>28</label>Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland, USA</aff><aff id="A29"><label>29</label>MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Edinburgh, UK</aff><aff id="A30"><label>30</label>Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</aff><aff id="A31"><label>31</label>Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK</aff><aff id="A32"><label>32</label>Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA</aff><aff id="A33"><label>33</label>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</aff><aff id="A34"><label>34</label>Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK</aff><aff id="A35"><label>35</label>Department of Public Health & Clinical Medicine, Genetic Epidemiology & Clinical Research Group, Umeå University Hospital, Umeå, Sweden</aff><aff id="A36"><label>36</label>Department of Odontology, Umeå University, Sweden</aff><aff id="A37"><label>37</label>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A38"><label>38</label>Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA</aff><aff id="A39"><label>39</label>Centre for medical systems biology, Netherlands Genomics Initiative, The Hague</aff><aff id="A40"><label>40</label>Netherlands Genomics Initiative and the Netherlands Consortium for Healthy Aging, Rotterdam, The Netherlands</aff><aff id="A41"><label>41</label>Department of Genetics Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, USA</aff><aff id="A42"><label>42</label>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</aff><aff id="A43"><label>43</label>Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA</aff><aff id="A44"><label>44</label>Icelandic Heart Association, Kopavogur, Iceland</aff><aff id="A45"><label>45</label>University of Iceland, Reykjavik, Iceland</aff><aff id="A46"><label>46</label>Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Kuopio, Finland</aff><aff id="A47"><label>47</label>Inserm, CESP Centre for research in Epidemiology and Population Health, Villejuif, France</aff><aff id="A48"><label>48</label>University Paris Sud 11, Villejuif, France</aff><aff id="A49"><label>49</label>Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy</aff><aff id="A50"><label>50</label>Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland</aff><aff id="A51"><label>51</label>Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland</aff><aff id="A52"><label>52</label>PathWest Laboratory Medicine of WA, J Block, QEII Medical Centre, Nedlands, Australia</aff><aff id="A53"><label>53</label>School of Pathology and Laboratory Medicine, The University of Western Australia, Nedlands, Australia</aff><aff id="A54"><label>54</label>Busselton Population Medical Research Foundation, B Block, QEII Medical Centre, Nedlands, Australia</aff><aff id="A55"><label>55</label>Texas Biomedical Research Institute, San Antonio, Texas, USA</aff><aff id="A56"><label>56</label>Department of Physiology & Biophysics, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA</aff><aff id="A57"><label>57</label>Department of Pharmacology, Faculty of Medicine, University of Split, Croatia</aff><aff id="A58"><label>58</label>Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA</aff><aff id="A59"><label>59</label>Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA</aff><aff id="A60"><label>60</label>IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany</aff><aff id="A61"><label>61</label>Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA</aff><aff id="A62"><label>62</label>University College London, Department of Epidemiology & Public Health, London, UK</aff><aff id="A63"><label>63</label>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</aff><aff id="A64"><label>64</label>Laboratory of Clinical Investigation, National Institute of Aging, Baltimore, Maryland, USA</aff><aff id="A65"><label>65</label>Clinical Trial Service Unit, University of Oxford, Oxford, UK</aff><aff id="A66"><label>66</label>Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA</aff><aff id="A67"><label>67</label>Department of Biostatistics, University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina, USA</aff><aff id="A68"><label>68</label>Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A69"><label>69</label>Department of Nutrition - Dietetics, Harokopio University, Athens, Greece</aff><aff id="A70"><label>70</label>Department of General Practice and Primary health Care, University of Helsinki, Finland</aff><aff id="A71"><label>71</label>Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland</aff><aff id="A72"><label>72</label>Folkhalsan Research Centre, Helsinki, Finland</aff><aff id="A73"><label>73</label>Vaasa Central Hospital, Vaasa, Finland</aff><aff id="A74"><label>74</label>National Institute for Health and Welfare, Helsinki, Finland</aff><aff id="A75"><label>75</label>Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA</aff><aff id="A76"><label>76</label>Robertson Centre for Biostatistics, University of Glasgow, UK</aff><aff id="A77"><label>77</label>National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA</aff><aff id="A78"><label>78</label>Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA</aff><aff id="A79"><label>79</label>Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research, Milan, Italy</aff><aff id="A80"><label>80</label>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</aff><aff id="A81"><label>81</label>Institut National de la Recherche Agronomique, Université Paris, Bobigny Cedex, France</aff><aff id="A82"><label>82</label>Genomic Medicine, Hammersmith Hospital, Imperial College London, London, UK</aff><aff id="A83"><label>83</label>Institut National de la Santé et de la Recherche Médicale, Université Paris, Bobigny Cedex, France</aff><aff id="A84"><label>84</label>Department of Medicine, Section of Preventive Medicine and Epidemiology, BU School of Medicine, Boston, Massachusetts, USA</aff><aff id="A85"><label>85</label>Department of Epidemiology, BU School of Public Health, Boston, Massachusetts, USA</aff><aff id="A86"><label>86</label>Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</aff><aff id="A87"><label>87</label>Department of Public Health & Clinical Medicine, Nutrition Research, Umeå University, Sweden</aff><aff id="A88"><label>88</label>Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA</aff><aff id="A89"><label>89</label>Centre National de Génotypage, Commissariat à L’Energie Atomique, Institut de Génomique, Evry, France</aff><aff id="A90"><label>90</label>Center for Biomedicine, European Academy Bozen/Bolzano, Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany</aff><aff id="A91"><label>91</label>Genetic epidemiology group, University College London, Department of Epidemiology & Public Health, London, UK</aff><aff id="A92"><label>92</label>School of Population Health, The University of Western Australia, Nedlands, Australia</aff><aff id="A93"><label>93</label>Sir Charles Gairdner Hospital Unit, School of Medicine & Pharmacology, University of Western Australia, Australia</aff><aff id="A94"><label>94</label>Department of Epidemiology and Biostatistics, School of Public Health, MRC-HPA Centre for Environment and Health, Faculty of Medicine, Imperial College London, UK</aff><aff id="A95"><label>95</label>Institute of Health Sciences, University of Oulu, Oulu, Finland</aff><aff id="A96"><label>96</label>Biocenter Oulu, University of Oulu, Oulu, Finland</aff><aff id="A97"><label>97</label>National Institute of Health and Welfare, Oulu, Finland</aff><aff id="A98"><label>98</label>Department of Cardiology C5-P, Leiden University Medical Center, Leiden, the Netherlands</aff><aff id="A99"><label>99</label>Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands</aff><aff id="A100"><label>100</label>Division of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland, USA</aff><aff id="A101"><label>101</label>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</aff><aff id="A102"><label>102</label>Hjelt Institute, Dept of Public Health, University of Helsinki, Finland</aff><aff id="A103"><label>103</label>Faculty of Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland</aff><aff id="A104"><label>104</label>Unit of General Practice, Oulu University Hospital, Oulu, Finland</aff><aff id="A105"><label>105</label>Department of Public Health, Faculty of Medicine, University of Split, Croatia</aff><aff id="A106"><label>106</label>Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany</aff><aff id="A107"><label>107</label>Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland</aff><aff id="A108"><label>108</label>Institute of Regional Health Services Research and Professor Odense Patient data Explorative Network (OPEN)</aff><aff id="A109"><label>109</label>Kuopio Research Institute of Exercise Medicine, Kuopio, Finland</aff><aff id="A110"><label>110</label>Department of Public Health and Caring Sciences, Uppsala University, Rudbecklaboratoriet, Uppsala, Sweden</aff><aff id="A111"><label>111</label>Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA</aff><aff id="A112"><label>112</label>Department of Medical Sciences, University Hospital, Uppsala University, Uppsala, Sweden</aff><aff id="A113"><label>113</label>Diabetes Prevention Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</aff><aff id="A114"><label>114</label>Estonian Genome Center, University of Tartu, Tartu, Estonia</aff><aff id="A115"><label>115</label>Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Paris, France</aff><aff id="A116"><label>116</label>Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA</aff><aff id="A117"><label>117</label>Division of Genetics, GlaxoSmithKline, Philadelphia, Pennsylvania, USA</aff><aff id="A118"><label>118</label>Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</aff><aff id="A119"><label>119</label>Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands</aff><aff id="A120"><label>120</label>Department of Medical Genetics, University of Helsinki and Helsinki University Central Hospital, Finland</aff><aff id="A121"><label>121</label>Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA</aff><aff id="A122"><label>122</label>Department of Biology, Faculty of Medicine, University of Split, Croatia</aff><aff id="A123"><label>123</label>Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="A124"><label>124</label>Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A125"><label>125</label>Department Psychiatry, EMGO Institute for Health and Care Research and Institute for Neurosciences, VU University Medical Center, Amsterdam, The Netherlands</aff><aff id="A126"><label>126</label>Institute for Anthropological Research, Zagreb, Croatia</aff><aff id="A127"><label>127</label>Department of Preventive Medicine, Laval University, Quebec, Canada</aff><aff id="A128"><label>128</label>Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland</aff><aff id="A129"><label>129</label>Department of Biostatistics, University of Washington, Seattle, Washington, USA</aff><aff id="A130"><label>130</label>Medical Genetics Institute, Cedars-Sinai Medical Center</aff><aff id="A131"><label>131</label>Centre for Global Health, University of Split, Croatia</aff><aff id="A132"><label>132</label>Institute of Clinical Medicine, University of Oulu, Finland</aff><aff id="A133"><label>133</label>Finnish Diabetes Association, Tampere, Finland</aff><aff id="A134"><label>134</label>Pirkanmaa Hospital District, Tampere, Finland</aff><aff id="A135"><label>135</label>Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK</aff><aff id="A136"><label>136</label>Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA</aff><aff id="A137"><label>137</label>Department of Medicine, Division Prevention and Care of Diabetes, University of Dresden, Dresden, Germany</aff><aff id="A138"><label>138</label>Leibniz Institute for Arteriosclerosis Research, University of Munster, Germany</aff><aff id="A139"><label>139</label>Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland, USA</aff><aff id="A140"><label>140</label>Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands</aff><aff id="A141"><label>141</label>Department of Medicine, University of Washington, Seattle, Washington, USA</aff><aff id="A142"><label>142</label>Department of Epidemiology, University of Washington, Seattle, Washington, USA</aff><aff id="A143"><label>143</label>Department of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands</aff><aff id="A144"><label>144</label>Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA</aff><aff id="A145"><label>145</label>Seattle Epidemiologic Research and Information Center, Veterans Affairs Office of Research and Development, Seattle, WA, USA</aff><aff id="A146"><label>146</label>Department of Medicine, University of Leipzig, Division of Endocrinology and Diabetes, Leipzig, Germany</aff><aff id="A147"><label>147</label>Department of Epidemiology, Emory University, Atlanta, Georgia, US</aff><aff id="A148"><label>148</label>Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</aff><aff id="A149"><label>149</label>South Ostrobothnia Central Hospital, Seinäjoki, Finland</aff><aff id="A150"><label>150</label>Hospital Universitario La Paz, Madrid, Spain</aff><aff id="A151"><label>151</label>Centre for Vascular Prevention, Danube-University Krems, Krems, Austria</aff><aff id="A152"><label>152</label>Institute of Public Health and Clinical Nutrition, University of Easten Finland, Kuopio, Finland</aff><aff id="A153"><label>153</label>Research Unit, Kuopio University Hospital, Kuopio, Finland</aff><aff id="A154"><label>154</label>Department of Food Science and Nutrition, Laval University, Quebec, Canada</aff><aff id="A155"><label>155</label>Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland</aff><aff id="A156"><label>156</label>Metabolic Disease Group, Wellcome Trust Sanger Institute, Hinxton, UK</aff><aff id="A157"><label>157</label>Institute for Molecular Medicine Finland, University of Helsinki, Finland</aff><aff id="A158"><label>158</label>Department of medical statistics, epidemiology and medical informatics, University of Zagreb, Zagreb, Croatia</aff><aff id="A159"><label>160</label>Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK</aff><aff id="A160"><label>161</label>University of Cambridge, Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK</aff><aff id="A161"><label>162</label>Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA</aff><aff id="A162"><label>163</label>Diabetes Research Center, Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, USA</aff><author-notes><corresp id="FN1"><label>†</label>Co-corresponding Authors: James B. Meigs, Harvard Medical School, General Medicine Division, Massachusetts General Hospital, 50 Staniford St 9th Floor, Boston MA 02114, Tel. 617-724-3203, Fax. 617-724-3544, <email>jmeigs@partners.org</email>, Claudia Langenberg, MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, United Kingdom, Tel. +44 (0)1223 769137, Fax. +44 (0)1223 330316, <email>Claudia.Langenberg@mrc-epid.cam.ac.uk</email></corresp><fn id="FN2"><label>159</label><p>A full list of members is provided in the <xref rid="SD1" ref-type="supplementary-material">Supplementary Note</xref></p></fn><fn id="FN3" fn-type="equal"><label>*</label><p>These authors contributed equally to this work</p></fn><fn id="FN4"><label>†</label><p>These authors jointly directed the work</p></fn><fn id="FN5"><label>**</label><p>Deceased</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>4</day><month>1</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>13</day><month>5</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>4</month><year>2013</year></pub-date><volume>44</volume><issue>6</issue><fpage>659</fpage><lpage>669</lpage><abstract><p id="P1">Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and beta-cell dysfunction, but contributed little to our understanding of the genetic basis of insulin resistance. We hypothesized that genes implicated in insulin resistance pathways may be uncovered by accounting for differences in body mass index (BMI) and potential interaction between BMI and genetic variants. We applied a novel joint meta-analytical approach to test associations with fasting insulin (FI) and glucose (FG) on a genome-wide scale. We present six previously unknown FI loci at <italic>P</italic><5×10<sup>−8</sup> in combined discovery and follow-up analyses of 52 studies comprising up to 96,496non-diabetic individuals. Risk variants were associated with higher triglyceride and lower HDL cholesterol levels, suggestive of a role for these FI loci in insulin resistance pathways. The localization of these additional loci will aid further characterization of the role of insulin resistance in T2D pathophysiology.</p></abstract><funding-group><award-group><funding-source country="United States">National Institute of Diabetes and Digestive and Kidney Diseases : NIDDK</funding-source><award-id>R01 DK078616 || DK</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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