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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Common variants at 12q15 and 12q24 are associated with infant head circumference</title><author><name sortKey="Taal, H Rob" sort="Taal, H Rob" uniqKey="Taal H" first="H Rob" last="Taal">H Rob Taal</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A3">The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Pourcain, Beate St" sort="Pourcain, Beate St" uniqKey="Pourcain B" first="Beate St" last="Pourcain">Beate St Pourcain</name><affiliation><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Thiering, Elisabeth" sort="Thiering, Elisabeth" uniqKey="Thiering E" first="Elisabeth" last="Thiering">Elisabeth Thiering</name><affiliation><nlm:aff id="A5">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Das, Shikta" sort="Das, Shikta" uniqKey="Das S" first="Shikta" last="Das">Shikta Das</name><affiliation><nlm:aff id="A6">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK</nlm:aff></affiliation></author><author><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O" last="Mook-Kanamori">Dennis O. Mook-Kanamori</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A3">The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Weill Cornell Medical College - Qatar, Doha, Qatar</nlm:aff></affiliation></author><author><name sortKey="Warrington, Nicole M" sort="Warrington, Nicole M" uniqKey="Warrington N" first="Nicole M" last="Warrington">Nicole M. Warrington</name><affiliation><nlm:aff id="A8">School of Women’s and Infants’ Health, The University of Western Australia, Perth, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Kaakinen, Marika" sort="Kaakinen, Marika" uniqKey="Kaakinen M" first="Marika" last="Kaakinen">Marika Kaakinen</name><affiliation><nlm:aff id="A10">Institute of Health Sciences, University of Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Biocenter Oulu, University of Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Kreiner M Ller, Eskil" sort="Kreiner M Ller, Eskil" uniqKey="Kreiner M Ller E" first="Eskil" last="Kreiner-M Ller">Eskil Kreiner-M Ller</name><affiliation><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Bradfield, Jonathan P" sort="Bradfield, Jonathan P" uniqKey="Bradfield J" first="Jonathan P" last="Bradfield">Jonathan P. Bradfield</name><affiliation><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Freathy, Rachel M" sort="Freathy, Rachel M" uniqKey="Freathy R" first="Rachel M" last="Freathy">Rachel M. Freathy</name><affiliation><nlm:aff id="A14">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff></affiliation></author><author><name sortKey="Geller, Frank" sort="Geller, Frank" uniqKey="Geller F" first="Frank" last="Geller">Frank Geller</name><affiliation><nlm:aff id="A15">Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Guxens, M Nica" sort="Guxens, M Nica" uniqKey="Guxens M" first="M Nica" last="Guxens">M Nica Guxens</name><affiliation><nlm:aff id="A16">Center for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Hospital del Mar Research Institute (IMIM), Barcelona, Catalonia, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain</nlm:aff></affiliation></author><author><name sortKey="Cousminer, Diana L" sort="Cousminer, Diana L" uniqKey="Cousminer D" first="Diana L" last="Cousminer">Diana L. Cousminer</name><affiliation><nlm:aff id="A19">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kerkhof, Marjan" sort="Kerkhof, Marjan" uniqKey="Kerkhof M" first="Marjan" last="Kerkhof">Marjan Kerkhof</name><affiliation><nlm:aff id="A20">Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J" last="Timpson">Nicholas J. Timpson</name><affiliation><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Beilin, Lawrence J" sort="Beilin, Lawrence J" uniqKey="Beilin L" first="Lawrence J" last="Beilin">Lawrence J. Beilin</name><affiliation><nlm:aff id="A22">School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia</nlm:aff></affiliation></author><author><name sortKey="B Nnelykke, Klaus" sort="B Nnelykke, Klaus" uniqKey="B Nnelykke K" first="Klaus" last="B Nnelykke">Klaus B Nnelykke</name><affiliation><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Buxton, Jessica L" sort="Buxton, Jessica L" uniqKey="Buxton J" first="Jessica L" last="Buxton">Jessica L. Buxton</name><affiliation><nlm:aff id="A23">Department of Genomics of Common Disease, School of Public Health, Imperial College London</nlm:aff></affiliation></author><author><name sortKey="Charoen, Pimphen" sort="Charoen, Pimphen" uniqKey="Charoen P" first="Pimphen" last="Charoen">Pimphen Charoen</name><affiliation><nlm:aff id="A6">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand</nlm:aff></affiliation></author><author><name sortKey="Chawes, Bo Lund Krogsgaard" sort="Chawes, Bo Lund Krogsgaard" uniqKey="Chawes B" first="Bo Lund Krogsgaard" last="Chawes">Bo Lund Krogsgaard Chawes</name><affiliation><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Johan" sort="Eriksson, Johan" uniqKey="Eriksson J" first="Johan" last="Eriksson">Johan Eriksson</name><affiliation><nlm:aff id="A25">National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Folkhalsan Research Centre, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M" last="Evans">David M. Evans</name><affiliation><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A3">The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kemp, John P" sort="Kemp, John P" uniqKey="Kemp J" first="John P" last="Kemp">John P. Kemp</name><affiliation><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Kim, Cecilia E" sort="Kim, Cecilia E" uniqKey="Kim C" first="Cecilia E" last="Kim">Cecilia E. Kim</name><affiliation><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Klopp, Norman" sort="Klopp, Norman" uniqKey="Klopp N" first="Norman" last="Klopp">Norman Klopp</name><affiliation><nlm:aff id="A28">Research Unit for Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A29">Hannover Unified Biobank, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><affiliation><nlm:aff id="A30">Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Lye, Stephen J" sort="Lye, Stephen J" uniqKey="Lye S" first="Stephen J" last="Lye">Stephen J. Lye</name><affiliation><nlm:aff id="A9">Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Mcmahon, George" sort="Mcmahon, George" uniqKey="Mcmahon G" first="George" last="Mcmahon">George Mcmahon</name><affiliation><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Mentch, Frank D" sort="Mentch, Frank D" uniqKey="Mentch F" first="Frank D" last="Mentch">Frank D. Mentch</name><affiliation><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Muller, Martina" sort="Muller, Martina" uniqKey="Muller M" first="Martina" last="Müller">Martina Müller</name><affiliation><nlm:aff id="A31">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="O Eilly, Paul F" sort="O Eilly, Paul F" uniqKey="O Eilly P" first="Paul F" last="O Eilly">Paul F. O Eilly</name><affiliation><nlm:aff id="A34">Department of Epidemiology and Biostatistics, Imperial College London, W2 1PG London, UK</nlm:aff></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation><nlm:aff id="A35">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Steegers, Eric A P" sort="Steegers, Eric A P" uniqKey="Steegers E" first="Eric A P" last="Steegers">Eric A P. Steegers</name><affiliation><nlm:aff id="A38">Department of Obstetrics & Gynecology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Sunyer, Jordi" sort="Sunyer, Jordi" uniqKey="Sunyer J" first="Jordi" last="Sunyer">Jordi Sunyer</name><affiliation><nlm:aff id="A16">Center for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Hospital del Mar Research Institute (IMIM), Barcelona, Catalonia, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Pompeu Fabra University (UPF), Barcelona, Catalonia, Spain</nlm:aff></affiliation></author><author><name sortKey="Tiesler, Carla" sort="Tiesler, Carla" uniqKey="Tiesler C" first="Carla" last="Tiesler">Carla Tiesler</name><affiliation><nlm:aff id="A5">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Dr Von Hauner Children’s Hospital, Ludwig-Maximilians University Munich, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Yaghootkar, Hanieh" sort="Yaghootkar, Hanieh" uniqKey="Yaghootkar H" first="Hanieh" last="Yaghootkar">Hanieh Yaghootkar</name><affiliation><nlm:aff id="A14">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff></affiliation></author><author><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M B" last="Breteler">Monique M B. Breteler</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name><affiliation><nlm:aff id="A42">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation><nlm:aff id="A43">Institute of Molecular Medicine, Human Genetics Center and Division of Epidemiology, School of Public Health, University of Texas, Houston Health Sciences Center, Houston, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="A44">Icelandic Heart Association, Kopavogus, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A45">University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><affiliation><nlm:aff id="A46">Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institute of Health, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Van Der Lugt, Aad" sort="Van Der Lugt, Aad" uniqKey="Van Der Lugt A" first="Aad" last="Van Der Lugt">Aad Van Der Lugt</name><affiliation><nlm:aff id="A21">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H" last="Mosley">Thomas H. Mosley</name><affiliation><nlm:aff id="A47">Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation><nlm:aff id="A42">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V" last="Smith">Albert V. Smith</name><affiliation><nlm:aff id="A44">Icelandic Heart Association, Kopavogus, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A45">University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W" last="Vernooij">Meike W. Vernooij</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Blakemore, Alexandra If" sort="Blakemore, Alexandra If" uniqKey="Blakemore A" first="Alexandra If" last="Blakemore">Alexandra If Blakemore</name><affiliation><nlm:aff id="A23">Department of Genomics of Common Disease, School of Public Health, Imperial College London</nlm:aff></affiliation></author><author><name sortKey="Chiavacci, Rosetta M" sort="Chiavacci, Rosetta M" uniqKey="Chiavacci R" first="Rosetta M" last="Chiavacci">Rosetta M. Chiavacci</name><affiliation><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Feenstra, Bjarke" sort="Feenstra, Bjarke" uniqKey="Feenstra B" first="Bjarke" last="Feenstra">Bjarke Feenstra</name><affiliation><nlm:aff id="A15">Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Fernandez Benet, Julio" sort="Fernandez Benet, Julio" uniqKey="Fernandez Benet J" first="Julio" last="Fernandez-Benet">Julio Fernandez-Benet</name><affiliation><nlm:aff id="A48">European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Grant, Struan F A" sort="Grant, Struan F A" uniqKey="Grant S" first="Struan F A" last="Grant">Struan F A. Grant</name><affiliation><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A50">Department of Pediatrics, University of Pennsylvania, Philadelphia PA 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation><nlm:aff id="A51">Institute of Clinical Medicine/Obstetrics and Gynecology, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Van Der Heijden, Albert J" sort="Van Der Heijden, Albert J" uniqKey="Van Der Heijden A" first="Albert J" last="Van Der Heijden">Albert J. Van Der Heijden</name><affiliation><nlm:aff id="A2">Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="I Iguez, Carmen" sort="I Iguez, Carmen" uniqKey="I Iguez C" first="Carmen" last="I Iguez">Carmen I Iguez</name><affiliation><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Division of Environment and Health, Center for Public Health Research-CSISP, Valencia, Spain</nlm:aff></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation><nlm:aff id="A53">Centre National de Génotypage, Evry, France</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Foundation Jean Dausset, CEPH, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L" last="Mcardle">Wendy L. Mcardle</name><affiliation><nlm:aff id="A55">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="M Lgaard, Anne" sort="M Lgaard, Anne" uniqKey="M Lgaard A" first="Anne" last="M Lgaard">Anne M Lgaard</name><affiliation><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Newnham, John P" sort="Newnham, John P" uniqKey="Newnham J" first="John P" last="Newnham">John P. Newnham</name><affiliation><nlm:aff id="A8">School of Women’s and Infants’ Health, The University of Western Australia, Perth, Australia</nlm:aff></affiliation></author><author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J" last="Palmer">Lyle J. Palmer</name><affiliation><nlm:aff id="A9">Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation><nlm:aff id="A19">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Department of Medical Genetics, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A58">Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Pouta, Annneli" sort="Pouta, Annneli" uniqKey="Pouta A" first="Annneli" last="Pouta">Annneli Pouta</name><affiliation><nlm:aff id="A60">National Institute for Health and Welfare, Oulu, Finland, Biocenter Oulu, University of Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M" last="Ring">Susan M. Ring</name><affiliation><nlm:aff id="A55">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Sovio, Ulla" sort="Sovio, Ulla" uniqKey="Sovio U" first="Ulla" last="Sovio">Ulla Sovio</name><affiliation><nlm:aff id="A6">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A61">London School of Hygiene and Tropical Medicine, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Standl, Marie" sort="Standl, Marie" uniqKey="Standl M" first="Marie" last="Standl">Marie Standl</name><affiliation><nlm:aff id="A5">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G" last="Uitterlinden">Andre G. Uitterlinden</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H-Erich" last="Wichmann">H-Erich Wichmann</name><affiliation><nlm:aff id="A5">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Vissing, Nadja Hawwa" sort="Vissing, Nadja Hawwa" uniqKey="Vissing N" first="Nadja Hawwa" last="Vissing">Nadja Hawwa Vissing</name><affiliation><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name><affiliation><nlm:aff id="A62">Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I" last="Mccarthy">Mark I. Mccarthy</name><affiliation><nlm:aff id="A35">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A63">Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Koppelman, Gerard H" sort="Koppelman, Gerard H" uniqKey="Koppelman G" first="Gerard H." last="Koppelman">Gerard H. Koppelman</name><affiliation><nlm:aff id="A64">Department of Pediatric Pulmonology and Pediatric Allergology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Estivill, Xavier" sort="Estivill, Xavier" uniqKey="Estivill X" first="Xavier" last="Estivill">Xavier Estivill</name><affiliation><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Pompeu Fabra University (UPF), Barcelona, Catalonia, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Genes and Disease Program, Center for Genomic Regulation (CRG-UPF), Barcelona, Catalonia, Spain</nlm:aff></affiliation></author><author><name sortKey="Hattersley, Andrew T" sort="Hattersley, Andrew T" uniqKey="Hattersley A" first="Andrew T" last="Hattersley">Andrew T. Hattersley</name><affiliation><nlm:aff id="A66">Peninsula NIHR Clinical Research Facility, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff></affiliation></author><author><name sortKey="Melbye, Mads" sort="Melbye, Mads" uniqKey="Melbye M" first="Mads" last="Melbye">Mads Melbye</name><affiliation><nlm:aff id="A15">Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Bisgaard, Hans" sort="Bisgaard, Hans" uniqKey="Bisgaard H" first="Hans" last="Bisgaard">Hans Bisgaard</name><affiliation><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E" last="Pennell">Craig E. Pennell</name><affiliation><nlm:aff id="A8">School of Women’s and Infants’ Health, The University of Western Australia, Perth, Australia</nlm:aff></affiliation></author><author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name><affiliation><nlm:aff id="A19">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A50">Department of Pediatrics, University of Pennsylvania, Philadelphia PA 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><affiliation><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name><affiliation><nlm:aff id="A5">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation><nlm:aff id="A10">Institute of Health Sciences, University of Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A60">National Institute for Health and Welfare, Oulu, Finland, Biocenter Oulu, University of Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, MRC Health Protection Agency (HPA) Centre for Environment and Health, Imperial College London</nlm:aff></affiliation></author><author><name sortKey="Jaddoe, Vincent W V" sort="Jaddoe, Vincent W V" uniqKey="Jaddoe V" first="Vincent W V" last="Jaddoe">Vincent W V. Jaddoe</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A3">The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22504419</idno><idno type="pmc">3773913</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773913</idno><idno type="RBID">PMC:3773913</idno><idno type="doi">10.1038/ng.2238</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002133</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002133</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Common variants at 12q15 and 12q24 are associated with infant head circumference</title><author><name sortKey="Taal, H Rob" sort="Taal, H Rob" uniqKey="Taal H" first="H Rob" last="Taal">H Rob Taal</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A3">The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Pourcain, Beate St" sort="Pourcain, Beate St" uniqKey="Pourcain B" first="Beate St" last="Pourcain">Beate St Pourcain</name><affiliation><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Thiering, Elisabeth" sort="Thiering, Elisabeth" uniqKey="Thiering E" first="Elisabeth" last="Thiering">Elisabeth Thiering</name><affiliation><nlm:aff id="A5">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Das, Shikta" sort="Das, Shikta" uniqKey="Das S" first="Shikta" last="Das">Shikta Das</name><affiliation><nlm:aff id="A6">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK</nlm:aff></affiliation></author><author><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O" last="Mook-Kanamori">Dennis O. Mook-Kanamori</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A3">The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Weill Cornell Medical College - Qatar, Doha, Qatar</nlm:aff></affiliation></author><author><name sortKey="Warrington, Nicole M" sort="Warrington, Nicole M" uniqKey="Warrington N" first="Nicole M" last="Warrington">Nicole M. Warrington</name><affiliation><nlm:aff id="A8">School of Women’s and Infants’ Health, The University of Western Australia, Perth, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Kaakinen, Marika" sort="Kaakinen, Marika" uniqKey="Kaakinen M" first="Marika" last="Kaakinen">Marika Kaakinen</name><affiliation><nlm:aff id="A10">Institute of Health Sciences, University of Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Biocenter Oulu, University of Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Kreiner M Ller, Eskil" sort="Kreiner M Ller, Eskil" uniqKey="Kreiner M Ller E" first="Eskil" last="Kreiner-M Ller">Eskil Kreiner-M Ller</name><affiliation><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Bradfield, Jonathan P" sort="Bradfield, Jonathan P" uniqKey="Bradfield J" first="Jonathan P" last="Bradfield">Jonathan P. Bradfield</name><affiliation><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Freathy, Rachel M" sort="Freathy, Rachel M" uniqKey="Freathy R" first="Rachel M" last="Freathy">Rachel M. Freathy</name><affiliation><nlm:aff id="A14">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff></affiliation></author><author><name sortKey="Geller, Frank" sort="Geller, Frank" uniqKey="Geller F" first="Frank" last="Geller">Frank Geller</name><affiliation><nlm:aff id="A15">Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Guxens, M Nica" sort="Guxens, M Nica" uniqKey="Guxens M" first="M Nica" last="Guxens">M Nica Guxens</name><affiliation><nlm:aff id="A16">Center for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Hospital del Mar Research Institute (IMIM), Barcelona, Catalonia, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain</nlm:aff></affiliation></author><author><name sortKey="Cousminer, Diana L" sort="Cousminer, Diana L" uniqKey="Cousminer D" first="Diana L" last="Cousminer">Diana L. Cousminer</name><affiliation><nlm:aff id="A19">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kerkhof, Marjan" sort="Kerkhof, Marjan" uniqKey="Kerkhof M" first="Marjan" last="Kerkhof">Marjan Kerkhof</name><affiliation><nlm:aff id="A20">Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J" last="Timpson">Nicholas J. Timpson</name><affiliation><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Beilin, Lawrence J" sort="Beilin, Lawrence J" uniqKey="Beilin L" first="Lawrence J" last="Beilin">Lawrence J. Beilin</name><affiliation><nlm:aff id="A22">School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia</nlm:aff></affiliation></author><author><name sortKey="B Nnelykke, Klaus" sort="B Nnelykke, Klaus" uniqKey="B Nnelykke K" first="Klaus" last="B Nnelykke">Klaus B Nnelykke</name><affiliation><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Buxton, Jessica L" sort="Buxton, Jessica L" uniqKey="Buxton J" first="Jessica L" last="Buxton">Jessica L. Buxton</name><affiliation><nlm:aff id="A23">Department of Genomics of Common Disease, School of Public Health, Imperial College London</nlm:aff></affiliation></author><author><name sortKey="Charoen, Pimphen" sort="Charoen, Pimphen" uniqKey="Charoen P" first="Pimphen" last="Charoen">Pimphen Charoen</name><affiliation><nlm:aff id="A6">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand</nlm:aff></affiliation></author><author><name sortKey="Chawes, Bo Lund Krogsgaard" sort="Chawes, Bo Lund Krogsgaard" uniqKey="Chawes B" first="Bo Lund Krogsgaard" last="Chawes">Bo Lund Krogsgaard Chawes</name><affiliation><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Johan" sort="Eriksson, Johan" uniqKey="Eriksson J" first="Johan" last="Eriksson">Johan Eriksson</name><affiliation><nlm:aff id="A25">National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Folkhalsan Research Centre, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M" last="Evans">David M. Evans</name><affiliation><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A3">The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kemp, John P" sort="Kemp, John P" uniqKey="Kemp J" first="John P" last="Kemp">John P. Kemp</name><affiliation><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Kim, Cecilia E" sort="Kim, Cecilia E" uniqKey="Kim C" first="Cecilia E" last="Kim">Cecilia E. Kim</name><affiliation><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Klopp, Norman" sort="Klopp, Norman" uniqKey="Klopp N" first="Norman" last="Klopp">Norman Klopp</name><affiliation><nlm:aff id="A28">Research Unit for Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A29">Hannover Unified Biobank, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><affiliation><nlm:aff id="A30">Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Lye, Stephen J" sort="Lye, Stephen J" uniqKey="Lye S" first="Stephen J" last="Lye">Stephen J. Lye</name><affiliation><nlm:aff id="A9">Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Mcmahon, George" sort="Mcmahon, George" uniqKey="Mcmahon G" first="George" last="Mcmahon">George Mcmahon</name><affiliation><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Mentch, Frank D" sort="Mentch, Frank D" uniqKey="Mentch F" first="Frank D" last="Mentch">Frank D. Mentch</name><affiliation><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Muller, Martina" sort="Muller, Martina" uniqKey="Muller M" first="Martina" last="Müller">Martina Müller</name><affiliation><nlm:aff id="A31">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="O Eilly, Paul F" sort="O Eilly, Paul F" uniqKey="O Eilly P" first="Paul F" last="O Eilly">Paul F. O Eilly</name><affiliation><nlm:aff id="A34">Department of Epidemiology and Biostatistics, Imperial College London, W2 1PG London, UK</nlm:aff></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation><nlm:aff id="A35">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Steegers, Eric A P" sort="Steegers, Eric A P" uniqKey="Steegers E" first="Eric A P" last="Steegers">Eric A P. Steegers</name><affiliation><nlm:aff id="A38">Department of Obstetrics & Gynecology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Sunyer, Jordi" sort="Sunyer, Jordi" uniqKey="Sunyer J" first="Jordi" last="Sunyer">Jordi Sunyer</name><affiliation><nlm:aff id="A16">Center for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Hospital del Mar Research Institute (IMIM), Barcelona, Catalonia, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Pompeu Fabra University (UPF), Barcelona, Catalonia, Spain</nlm:aff></affiliation></author><author><name sortKey="Tiesler, Carla" sort="Tiesler, Carla" uniqKey="Tiesler C" first="Carla" last="Tiesler">Carla Tiesler</name><affiliation><nlm:aff id="A5">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Dr Von Hauner Children’s Hospital, Ludwig-Maximilians University Munich, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Yaghootkar, Hanieh" sort="Yaghootkar, Hanieh" uniqKey="Yaghootkar H" first="Hanieh" last="Yaghootkar">Hanieh Yaghootkar</name><affiliation><nlm:aff id="A14">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff></affiliation></author><author><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M B" last="Breteler">Monique M B. Breteler</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name><affiliation><nlm:aff id="A42">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation><nlm:aff id="A43">Institute of Molecular Medicine, Human Genetics Center and Division of Epidemiology, School of Public Health, University of Texas, Houston Health Sciences Center, Houston, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="A44">Icelandic Heart Association, Kopavogus, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A45">University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><affiliation><nlm:aff id="A46">Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institute of Health, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Van Der Lugt, Aad" sort="Van Der Lugt, Aad" uniqKey="Van Der Lugt A" first="Aad" last="Van Der Lugt">Aad Van Der Lugt</name><affiliation><nlm:aff id="A21">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H" last="Mosley">Thomas H. Mosley</name><affiliation><nlm:aff id="A47">Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation><nlm:aff id="A42">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V" last="Smith">Albert V. Smith</name><affiliation><nlm:aff id="A44">Icelandic Heart Association, Kopavogus, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A45">University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W" last="Vernooij">Meike W. Vernooij</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Blakemore, Alexandra If" sort="Blakemore, Alexandra If" uniqKey="Blakemore A" first="Alexandra If" last="Blakemore">Alexandra If Blakemore</name><affiliation><nlm:aff id="A23">Department of Genomics of Common Disease, School of Public Health, Imperial College London</nlm:aff></affiliation></author><author><name sortKey="Chiavacci, Rosetta M" sort="Chiavacci, Rosetta M" uniqKey="Chiavacci R" first="Rosetta M" last="Chiavacci">Rosetta M. Chiavacci</name><affiliation><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Feenstra, Bjarke" sort="Feenstra, Bjarke" uniqKey="Feenstra B" first="Bjarke" last="Feenstra">Bjarke Feenstra</name><affiliation><nlm:aff id="A15">Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Fernandez Benet, Julio" sort="Fernandez Benet, Julio" uniqKey="Fernandez Benet J" first="Julio" last="Fernandez-Benet">Julio Fernandez-Benet</name><affiliation><nlm:aff id="A48">European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Grant, Struan F A" sort="Grant, Struan F A" uniqKey="Grant S" first="Struan F A" last="Grant">Struan F A. Grant</name><affiliation><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A50">Department of Pediatrics, University of Pennsylvania, Philadelphia PA 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation><nlm:aff id="A51">Institute of Clinical Medicine/Obstetrics and Gynecology, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Van Der Heijden, Albert J" sort="Van Der Heijden, Albert J" uniqKey="Van Der Heijden A" first="Albert J" last="Van Der Heijden">Albert J. Van Der Heijden</name><affiliation><nlm:aff id="A2">Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="I Iguez, Carmen" sort="I Iguez, Carmen" uniqKey="I Iguez C" first="Carmen" last="I Iguez">Carmen I Iguez</name><affiliation><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Division of Environment and Health, Center for Public Health Research-CSISP, Valencia, Spain</nlm:aff></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation><nlm:aff id="A53">Centre National de Génotypage, Evry, France</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Foundation Jean Dausset, CEPH, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L" last="Mcardle">Wendy L. Mcardle</name><affiliation><nlm:aff id="A55">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="M Lgaard, Anne" sort="M Lgaard, Anne" uniqKey="M Lgaard A" first="Anne" last="M Lgaard">Anne M Lgaard</name><affiliation><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Newnham, John P" sort="Newnham, John P" uniqKey="Newnham J" first="John P" last="Newnham">John P. Newnham</name><affiliation><nlm:aff id="A8">School of Women’s and Infants’ Health, The University of Western Australia, Perth, Australia</nlm:aff></affiliation></author><author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J" last="Palmer">Lyle J. Palmer</name><affiliation><nlm:aff id="A9">Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation><nlm:aff id="A19">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Department of Medical Genetics, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A58">Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Pouta, Annneli" sort="Pouta, Annneli" uniqKey="Pouta A" first="Annneli" last="Pouta">Annneli Pouta</name><affiliation><nlm:aff id="A60">National Institute for Health and Welfare, Oulu, Finland, Biocenter Oulu, University of Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M" last="Ring">Susan M. Ring</name><affiliation><nlm:aff id="A55">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Sovio, Ulla" sort="Sovio, Ulla" uniqKey="Sovio U" first="Ulla" last="Sovio">Ulla Sovio</name><affiliation><nlm:aff id="A6">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A61">London School of Hygiene and Tropical Medicine, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Standl, Marie" sort="Standl, Marie" uniqKey="Standl M" first="Marie" last="Standl">Marie Standl</name><affiliation><nlm:aff id="A5">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G" last="Uitterlinden">Andre G. Uitterlinden</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H-Erich" last="Wichmann">H-Erich Wichmann</name><affiliation><nlm:aff id="A5">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Vissing, Nadja Hawwa" sort="Vissing, Nadja Hawwa" uniqKey="Vissing N" first="Nadja Hawwa" last="Vissing">Nadja Hawwa Vissing</name><affiliation><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name><affiliation><nlm:aff id="A62">Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I" last="Mccarthy">Mark I. Mccarthy</name><affiliation><nlm:aff id="A35">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A63">Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Koppelman, Gerard H" sort="Koppelman, Gerard H" uniqKey="Koppelman G" first="Gerard H." last="Koppelman">Gerard H. Koppelman</name><affiliation><nlm:aff id="A64">Department of Pediatric Pulmonology and Pediatric Allergology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Estivill, Xavier" sort="Estivill, Xavier" uniqKey="Estivill X" first="Xavier" last="Estivill">Xavier Estivill</name><affiliation><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Pompeu Fabra University (UPF), Barcelona, Catalonia, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Genes and Disease Program, Center for Genomic Regulation (CRG-UPF), Barcelona, Catalonia, Spain</nlm:aff></affiliation></author><author><name sortKey="Hattersley, Andrew T" sort="Hattersley, Andrew T" uniqKey="Hattersley A" first="Andrew T" last="Hattersley">Andrew T. Hattersley</name><affiliation><nlm:aff id="A66">Peninsula NIHR Clinical Research Facility, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff></affiliation></author><author><name sortKey="Melbye, Mads" sort="Melbye, Mads" uniqKey="Melbye M" first="Mads" last="Melbye">Mads Melbye</name><affiliation><nlm:aff id="A15">Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Bisgaard, Hans" sort="Bisgaard, Hans" uniqKey="Bisgaard H" first="Hans" last="Bisgaard">Hans Bisgaard</name><affiliation><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E" last="Pennell">Craig E. Pennell</name><affiliation><nlm:aff id="A8">School of Women’s and Infants’ Health, The University of Western Australia, Perth, Australia</nlm:aff></affiliation></author><author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name><affiliation><nlm:aff id="A19">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A50">Department of Pediatrics, University of Pennsylvania, Philadelphia PA 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><affiliation><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name><affiliation><nlm:aff id="A5">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation><nlm:aff id="A10">Institute of Health Sciences, University of Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A60">National Institute for Health and Welfare, Oulu, Finland, Biocenter Oulu, University of Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, MRC Health Protection Agency (HPA) Centre for Environment and Health, Imperial College London</nlm:aff></affiliation></author><author><name sortKey="Jaddoe, Vincent W V" sort="Jaddoe, Vincent W V" uniqKey="Jaddoe V" first="Vincent W V" last="Jaddoe">Vincent W V. Jaddoe</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A3">The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P7">To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association (GWA) studies (N=10,768 from European ancestry enrolled in pregnancy/birth cohorts) and followed up three lead signals in six replication studies (combined N=19,089). Rs7980687 on chromosome 12q24 (<italic>P</italic>=8.1×10<sup>−9</sup>), and rs1042725 on chromosome 12q15 (<italic>P</italic>=2.8×10<sup>−10</sup>) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height<sup><xref ref-type="bibr" rid="R1">1</xref></sup>, their effects on infant head circumference were largely independent of height (<italic>P</italic>=3.8×10<sup>−7</sup> for rs7980687, <italic>P</italic>=1.3×10<sup>−7</sup> for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (<italic>P</italic>=3.9×10<sup>−6</sup>). SNPs correlated to the 17q21 signal show genome-wide association with adult intra cranial volume<sup><xref ref-type="bibr" rid="R2">2</xref></sup>, Parkinson’s disease and other neurodegenerative diseases<sup><xref ref-type="bibr" rid="R3">3</xref>-<xref ref-type="bibr" rid="R5">5</xref></sup>, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id><journal-id journal-id-type="pubmed-jr-id">2419</journal-id><journal-id journal-id-type="nlm-ta">Nat Genet</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Genet.</journal-id><journal-title-group><journal-title>Nature genetics</journal-title></journal-title-group><issn pub-type="ppub">1061-4036</issn><issn pub-type="epub">1546-1718</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22504419</article-id><article-id pub-id-type="pmc">3773913</article-id><article-id pub-id-type="doi">10.1038/ng.2238</article-id><article-id pub-id-type="manuscript">EMS54331</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Common variants at 12q15 and 12q24 are associated with infant head circumference</article-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Taal</surname><given-names>H Rob</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author" 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contrib-type="author"><name><surname>Bisgaard</surname><given-names>Hans</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Pennell</surname><given-names>Craig E</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Widen</surname><given-names>Elisabeth</given-names></name><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Hakonarson</surname><given-names>Hakon</given-names></name><xref ref-type="aff" rid="A13">13</xref><xref ref-type="aff" rid="A49">49</xref><xref ref-type="aff" rid="A50">50</xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>George Davey</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="corresp" rid="CR1">†</xref></contrib><contrib contrib-type="author"><name><surname>Heinrich</surname><given-names>Joachim</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref ref-type="corresp" rid="CR1">†</xref></contrib><contrib contrib-type="author"><name><surname>Jarvelin</surname><given-names>Marjo-Riitta</given-names></name><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A60">60</xref><xref ref-type="aff" rid="A67">67</xref><xref ref-type="corresp" rid="CR1">†</xref></contrib><contrib contrib-type="author"><collab>Early Growth Genetics (EGG) Consortium</collab><xref ref-type="aff" rid="A41">41</xref></contrib><contrib contrib-type="author"><name><surname>Jaddoe</surname><given-names>Vincent W V</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="corresp" rid="CR1">†</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</aff><aff id="A2"><label>2</label>Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands</aff><aff id="A3"><label>3</label>The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands</aff><aff id="A4"><label>4</label>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</aff><aff id="A5"><label>5</label>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="A6"><label>6</label>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK</aff><aff id="A7"><label>7</label>Weill Cornell Medical College - Qatar, Doha, Qatar</aff><aff id="A8"><label>8</label>School of Women’s and Infants’ Health, The University of Western Australia, Perth, Australia</aff><aff id="A9"><label>9</label>Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Canada</aff><aff id="A10"><label>10</label>Institute of Health Sciences, University of Oulu, Finland</aff><aff id="A11"><label>11</label>Biocenter Oulu, University of Oulu, Finland</aff><aff id="A12"><label>12</label>Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</aff><aff id="A13"><label>13</label>Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</aff><aff id="A14"><label>14</label>Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</aff><aff id="A15"><label>15</label>Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark</aff><aff id="A16"><label>16</label>Center for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, Spain</aff><aff id="A17"><label>17</label>Hospital del Mar Research Institute (IMIM), Barcelona, Catalonia, Spain</aff><aff id="A18"><label>18</label>CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain</aff><aff id="A19"><label>19</label>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</aff><aff id="A20"><label>20</label>Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.</aff><aff id="A21"><label>21</label>Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</aff><aff id="A22"><label>22</label>School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia</aff><aff id="A23"><label>23</label>Department of Genomics of Common Disease, School of Public Health, Imperial College London</aff><aff id="A24"><label>24</label>Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand</aff><aff id="A25"><label>25</label>National Institute for Health and Welfare, Helsinki, Finland</aff><aff id="A26"><label>26</label>Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland</aff><aff id="A27"><label>27</label>Folkhalsan Research Centre, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland</aff><aff id="A28"><label>28</label>Research Unit for Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="A29"><label>29</label>Hannover Unified Biobank, Hannover Medical School, Hannover, Germany</aff><aff id="A30"><label>30</label>Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland</aff><aff id="A31"><label>31</label>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</aff><aff id="A32"><label>32</label>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="A33"><label>33</label>Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany</aff><aff id="A34"><label>34</label>Department of Epidemiology and Biostatistics, Imperial College London, W2 1PG London, UK</aff><aff id="A35"><label>35</label>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK</aff><aff id="A36"><label>36</label>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</aff><aff id="A37"><label>37</label>Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</aff><aff id="A38"><label>38</label>Department of Obstetrics & Gynecology, Erasmus Medical Center, Rotterdam, The Netherlands</aff><aff id="A39"><label>39</label>Pompeu Fabra University (UPF), Barcelona, Catalonia, Spain</aff><aff id="A40"><label>40</label>Dr Von Hauner Children’s Hospital, Ludwig-Maximilians University Munich, Munich, Germany</aff><aff id="A41"><label>41</label>A full list of members and affiliations is provided at the end of the manuscript</aff><aff id="A42"><label>42</label>Department of Neurology, Boston University School of Medicine, Boston, MA, USA</aff><aff id="A43"><label>43</label>Institute of Molecular Medicine, Human Genetics Center and Division of Epidemiology, School of Public Health, University of Texas, Houston Health Sciences Center, Houston, TX, USA</aff><aff id="A44"><label>44</label>Icelandic Heart Association, Kopavogus, Iceland</aff><aff id="A45"><label>45</label>University of Iceland, Reykjavik, Iceland</aff><aff id="A46"><label>46</label>Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institute of Health, Bethesda, MD, USA</aff><aff id="A47"><label>47</label>Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS, USA</aff><aff id="A48"><label>48</label>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom</aff><aff id="A49"><label>49</label>Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</aff><aff id="A50"><label>50</label>Department of Pediatrics, University of Pennsylvania, Philadelphia PA 19104, USA</aff><aff id="A51"><label>51</label>Institute of Clinical Medicine/Obstetrics and Gynecology, University of Oulu, Oulu, Finland</aff><aff id="A52"><label>52</label>Division of Environment and Health, Center for Public Health Research-CSISP, Valencia, Spain</aff><aff id="A53"><label>53</label>Centre National de Génotypage, Evry, France</aff><aff id="A54"><label>54</label>Foundation Jean Dausset, CEPH, Paris, France</aff><aff id="A55"><label>55</label>School of Social and Community Medicine, University of Bristol, Bristol, UK</aff><aff id="A56"><label>56</label>Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, Ontario, Canada</aff><aff id="A57"><label>57</label>Department of Medical Genetics, University of Helsinki, Helsinki, Finland</aff><aff id="A58"><label>58</label>Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA</aff><aff id="A59"><label>59</label>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</aff><aff id="A60"><label>60</label>National Institute for Health and Welfare, Oulu, Finland, Biocenter Oulu, University of Oulu, Finland</aff><aff id="A61"><label>61</label>London School of Hygiene and Tropical Medicine, London, United Kingdom</aff><aff id="A62"><label>62</label>Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA, USA</aff><aff id="A63"><label>63</label>Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK</aff><aff id="A64"><label>64</label>Department of Pediatric Pulmonology and Pediatric Allergology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A65"><label>65</label>Genes and Disease Program, Center for Genomic Regulation (CRG-UPF), Barcelona, Catalonia, Spain</aff><aff id="A66"><label>66</label>Peninsula NIHR Clinical Research Facility, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</aff><aff id="A67"><label>67</label>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, MRC Health Protection Agency (HPA) Centre for Environment and Health, Imperial College London</aff><author-notes><corresp id="CR1"><label>†</label></corresp><corresp id="CR2"><bold>Corresponding author contact details:</bold><bold>George Davey Smith</bold>, The MRC Centre for Causal Analyses, in Translational Epidemiology, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK, Tel. +44 (0)117 3310095, Fax. +44 (0)117 3310123, <email>Julia.Mackay@bristol.ac.uk</email>, <bold>Marjo-Riitta Jarvelin</bold> Department of Epidemiology and, Public Health, Imperial College London, London, UK, Tel. +44 (0)207 5943345, Fax. +44 (0)207 4022150, <email>m.jarvelin@imperial.ac.uk</email>, <bold>Joachim Heinrich</bold>, Helmholtz Zentrum Muenchen, German Research Centre for, Environmental Health, Institute of, Epidemiology, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany, Tel. +49 (0)89-31874150, Fax +49 (0)89-31873380, <email>Joachim.heinrich@helmholtzmuenchen.de</email>, <bold>Vincent V. W. Jaddoe</bold>, Generation R Study Group (Room, AE 006), Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, the Netherlands, Tel. +31 (0)10 7043405, Fax. +31 (0)10 7044645, <email>v.jaddoe@erasmusmc.nl</email></corresp><fn id="FN1"><p id="P1">AUTHOR CONTRIBUTIONS</p><p id="P2"><bold>Project Design:</bold> H.R.T., J.P.B., F.G., M.Kerkhof, A.H., E.A.P.S., J.S., M.M.B.B., L.J.L., A.vdL., T.H.M., S.S., A.V.S., B.F., S.F.A.G., A.J.vdH., J.P.N., L.J.P., H-E.W., C.DeC., M.McC., G.K., X.E., A.T.H., M.Melbye, H.B., C.E.P., H.H., G.D.S., J.H., M-R.J., V.W.V.J.</p><p id="P3"><bold>Sample collection and phenotyping:</bold> H.R.T., M.Kaakinen, M.G., M.Kerkhof, M.A.I., K.B., B.L.K.C., J.E., F.D.M.,I.P., J.S., S.D., M.F., V.G., S.S., M.W.V., J.F-B., R.M.C., A-L.H., C.I., A.M., J.P.N., A.Pouta., U.S., M.S., N.H.V., G.K., A.T.H., H.H., M-R.J., V.W.V.J.</p><p id="P4"><bold>Genotyping:</bold> R.M.F., L.J.B., J.L.B., C.E.K., S.J.L., N.K., M. Müller, F.R., C.T., A.B., A-L.H., M.L., W.L.M., J.P.N., L.J.P., A.Palotie, S.M.R., A.U.G., C.M.vD., X.E., C.E.P., E.W., M-R.J.</p><p id="P5"><bold>Statistical analysis:</bold> H.R.T., B.StP., E.T., S.D., D.O.M-K, N.M.W., M.Kaakinen, E.K-M., J.P.B., R.M.F., F.G., D.L.C., M.Kerkhof., N.J.T., M.A.I., P.C., D.M.E., J.P.K., J.L., G.McM., P.F.O., H.Y., S.S., B.F., S.F.A.G., U.S., C.DeC.</p><p id="P6"><bold>Writing:</bold> H.R.T., B.StP., E.T., S.D., D.O.M-K., G.D.S., J.H., M-R.J., V.W.V.J.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>20</day><month>8</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>15</day><month>4</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>16</day><month>9</month><year>2013</year></pub-date><volume>44</volume><issue>5</issue><fpage>532</fpage><lpage>538</lpage><abstract><p id="P7">To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association (GWA) studies (N=10,768 from European ancestry enrolled in pregnancy/birth cohorts) and followed up three lead signals in six replication studies (combined N=19,089). Rs7980687 on chromosome 12q24 (<italic>P</italic>=8.1×10<sup>−9</sup>), and rs1042725 on chromosome 12q15 (<italic>P</italic>=2.8×10<sup>−10</sup>) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height<sup><xref ref-type="bibr" rid="R1">1</xref></sup>, their effects on infant head circumference were largely independent of height (<italic>P</italic>=3.8×10<sup>−7</sup> for rs7980687, <italic>P</italic>=1.3×10<sup>−7</sup> for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (<italic>P</italic>=3.9×10<sup>−6</sup>). SNPs correlated to the 17q21 signal show genome-wide association with adult intra cranial volume<sup><xref ref-type="bibr" rid="R2">2</xref></sup>, Parkinson’s disease and other neurodegenerative diseases<sup><xref ref-type="bibr" rid="R3">3</xref>-<xref ref-type="bibr" rid="R5">5</xref></sup>, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.</p></abstract><funding-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>079643 || WT</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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